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Transplante de Útero: uma revisão da literatura
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Brito, Inês

; Martins, Renato Silva

Acta Obstétrica e Ginecológica Portuguesa

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jun 2024, Volume 18 N. 2 Pages 115 - 122

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract In the last few decades, research using animal models, clinical trials and several scientific advances in reproductive surgery have led to the introduction of uterine transplantation (UTx) as a possible treatment for uterine factor infertility (UFI). For that reason, UTx assumes clinical relevance as it constitutes an alternative to adoption and surrogacy which, for various reasons, may be unfeasible options for women. This literature review aims to analyze the current scientific evidence on uterus transplantation and present the most relevant aspects about the procedure.

Resumo Nas últimas décadas, a investigação com recurso a modelos animais e ensaios clínicos, a par dos avanços científicos no campo da cirurgia reprodutiva, permitiram a introdução do transplante de útero (TxU) enquanto tratamento da infertilidade devido a fator uterino (IFU). Assim, o TxU assume relevância clínica por ser um possível tratamento da IFU e, portanto, uma alternativa à adoção e gestação de substituição que, por diversas razões, poderão ser opções inviáveis para as mulheres. A presente revisão da literatura pretende analisar a atual evidência científica sobre o TxU e apresentar os aspetos mais relevantes sobre o procedimento.

https://doi.org/10.69729/aogp.v18i2a05

O uso da gamificação no ensino da fisiologia renal
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Parahyba Júnior, Marcelo Coelho

; Martins, Renato Brito Oliveira

; Weyne, Karla Maryana Lima Loiola

; Nogueira, Natália Pessoa Eufrásio

; Ponte, Edson Lopes da

; Marques, Gabriela Fernandes Oliveira

; Silva, Leidiane Pinho da

Revista Brasileira de Educação Médica

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2024, Volume 48 N. 4 elocation e131

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: O modelo tradicional de ensino em que o professor é o mentor do processo educativo, tendo enfoque em extensas aulas expositivas, ainda é bastante predominante nas instituições de ensino de diferentes níveis de escolaridade. Esse cenário pode ser considerado incongruente com a nova era tecnológica e o novo modo de pensar. Em contrapartida, a gamificação é uma metodologia ativa que visa tornar o aluno o centro do aprendizado, a fim de aumentar o interesse dele e melhorar a absorção do conteúdo. Objetivo: O presente estudo visa analisar a percepção de alunos do segundo semestre de um curso de Medicina sobre a utilização de um jogo que contempla os principais conceitos da fisiologia renal. Método: Trata-se de um estudo descritivo, do tipo prospectivo. A atividade consistiu em uma dinâmica que usou um jogo de tabuleiro com cartas sobre a fisiologia renal para 104 alunos. Em seguida, foi aplicado um questionário com 11 perguntas, majoritariamente objetivas, cujas principais variáveis investigadas foram a experiência prévia com a gamificação, a adequação da duração da aula prática, como os discentes avaliaram o uso da gamificação da aula prática, entre outras. Resultado: Os resultados mostraram que a maioria dos alunos afirmou ser esse tipo de metodologia estimulante (93,3%) e que auxilia no estudo dos assuntos propostos (94,2%), consolidando os temas já vistos em sala de aula pelo método tradicional. Também foi pontuado pelos estudantes que a melhor maneira de assimilar o conteúdo seria adicionar a gamificação, após o método tradicional de exposição dialogada (61,5%). Quando questionados sobre a percepção do uso de gamificação nas aulas práticas, a maioria a classificou como ótima (65,4%) ou boa (30,8%). Conclusão: Diante dos resultados expostos, pode-se concluir que a gamificação se mostrou uma excelente aliada à aula teórica tradicional, servindo como mecanismo de sedimentação e aumento de interesse para os discentes. Introdução educativo expositivas escolaridade pensar contrapartida aprendizado Objetivo Método Tratase Trata descritivo prospectivo 10 seguida 1 perguntas objetivas prática outras Resultado 93,3% 933 93 3 (93,3% 94,2%, 942 94,2% , 94 2 (94,2%) 61,5%. 615 61,5% . 61 5 (61,5%) práticas 65,4% 654 65 4 (65,4% 30,8%. 308 30,8% 30 8 (30,8%) Conclusão expostos podese 93,3 9 (93,3 94,2 (94,2% 61,5 6 (61,5% 65,4 (65,4 30,8 (30,8% 93, (93, 94, (94,2 61, (61,5 65, (65, 30, (30,8 (93 (94, (61, (65 (30, (9 (94 (61 (6 (30 ( (3

ABSTRACT Introduction: The traditional teaching model, in which the teacher is the mentor of the educational process and focuses on extensive lectures, is still quite prevalent in educational institutions at different levels of education. This scenario can be considered incongruent with the new technological era and new way of thinking. In contrast, gamification is an active methodology that aims to make the student the center of learning, aiming to increase their interest and improve content absorption. Objective: This study aims to analyze the perception of students attending the second semester of a medical course about the use of a game that covers the main concepts of renal physiology. Method: This is a descriptive, prospective study. The activity consisted of a dynamic that used a board game with cards about renal physiology for 104 students. Subsequently, a questionnaire with 11 questions was applied, mostly objective, whose main variables investigated were previous experience with gamification, the adequacy of the practical class duration, how they evaluated the use of gamification in the practical class, among others. Results: The results showed that most students stated that this type of methodology is stimulating (93.3%) and that it helps in the study of the proposed subjects (94.2%), consolidating the topics previously covered in the classroom using the traditional method. The students also pointed out that the best way to assimilate the content would be to add gamification, after the traditional method of dialogue exposition (61.5%). When asked about their perception of the use of gamification in practical classes, most students classified it as excellent (65.4%) or good (30.8%). Conclusion: Given the results presented herein, it can be concluded that gamification proved to be an excellent ally to the traditional theoretical class, serving as a mechanism for sedimentation and increased interest for students. Introduction model lectures education thinking contrast learning absorption Objective Method descriptive 10 Subsequently 1 applied objective duration others Results 93.3% 933 93 3 (93.3% 94.2%, 942 94.2% , 94 2 (94.2%) 61.5%. 615 61.5% . 61 5 (61.5%) classes 65.4% 654 65 4 (65.4% 30.8%. 308 30.8% 30 8 (30.8%) Conclusion herein 93.3 9 (93.3 94.2 (94.2% 61.5 6 (61.5% 65.4 (65.4 30.8 (30.8% 93. (93. 94. (94.2 61. (61.5 65. (65. 30. (30.8 (93 (94. (61. (65 (30. (9 (94 (61 (6 (30 ( (3

https://doi.org/10.1590/1981-5271v48.4-2024-0013

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Suppl. 3 elocation e23022

Abstract: En | Text: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development. (SB Brazil However programs SANSED cruise SANAGU 356 (35 201 2021/2022. 20212022 2021/2022 . 2021 2022 2021/2022) ecology biogeochemistry masses patterns geomorphology sedimentology chemistry board approaches analyses GOMEXtype GOMEX type 0.25 025 0 (0.2 m² 0.75 075 75 (0.7 10 240 depth station physicochemical physico chemical micro, micro , micro- meio, meio meio- system 6 community pico macroplankton vertical horizontal 20, 20 (20 200 50 size, size) CTDrosette CTD rosette sampler PCRBS PCR BS (PCR-BS IBAMA Development 35 (3 2021202 2021/202 202 0.2 02 (0. 0.7 07 7 1 (2 5 3 ( 202120 2021/20 0. (0 20212 2021/2 2021/

https://doi.org/10.1590/2675-2824071.22072dlm

Hydrographic structure of the continental shelf in Santos Basin and its causes: The SANAGU and SANSED campaigns (2019) causes 2019 (2019 201 (201 20 (20 2 (2 (
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Dottori, Marcelo

; Sasaki, Dalton K.

; Silva, Danilo A.

; Del–Giovannino, Sergio R.

; Pinto, Andressa P.

; Gnamah, Magnim

; Santos, Arian D.

; Silveira, Ilson C. A. da

; Belo, Wellington C.

; Martins, Renato P.

; Moreira, Daniel L.

Ocean and Coastal Research

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2023, Volume 71 Suppl. 3 elocation e23013

Abstract: En | Text: En | PDF: En

Abstract This study describes the hydrography and water masses of the Santos Basin Continental Shelf (SBCS) during two hydrographic campaigns (SANAGU, SANSED) in 2019. Coastal Water (CW) is the dominant water mass in the southern portion of the SBCS, with relatively low salinity values (S<35.5 g kg–1), and satellite data show that local precipitation and river discharge could not account for the low salinity observed during the cruises in the southern region of the domain. The low salinity observed is explained by the transport from the south influenced by Subtropical Shelf Water (STSW), which was influenced by the La Plata River discharge. In the northern region of the SBCS, the South Atlantic Central Water (SACW) dominates the bottom layers of the water column, with the wind playing a major role in the uplift of this water mass, as evidenced by a wind impulse analysis. In this part of the shelf, Tropical Water (TW) was the second water mass in volume and occupied the surface layers and offshore the shelf. CW is restricted to a thin surface layer, which reaches distances of a few kilometers from the coast. Our analysis show the differences in the hydrographic structure of the SBCS and suggests that the SBCS can be divided in two regions with distinct characteristics: 1) the area southwest of São Sebastião, where the hydrographic parameters were modulated by the presence of the Subtropical Shelf Water (STSW); 2) the area northeast of São Sebastião, where the uplifting of SACW was the dominant process. (SBCS SANAGU, SANAGU (SANAGU SANSED 2019 (CW S<35.5 S355 S 35 5 (S<35. kg–1, kg1 kg kg–1 , 1 kg–1) domain STSW, STSW (STSW) (SACW column shelf TW (TW layer coast characteristics Sebastião 2 process 201 S<35. S35 3 (S<35 kg– (STSW 20 S<35 S3 (S<3 S<3 (S< S< (S

https://doi.org/10.1590/2675-2824071.22062md

Oceanographic conditions of the continental slope and deep waters in Santos Basin: the SANSED cruise (winter 2019)
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Silveira, Ilson C. A. da

; Bernardo, Piero S.

; Lazaneo, Cauê Z.

; Amorim, João P. M.

; Borges-Silva, Milton

; Martins, Rafael C.

; Santos, Daniel M. C.

; Dottori, Marcelo

; Belo, Wellington C.

; Martins, Renato P.

; Guerra, Luiz A. A.

; Moreira, Daniel L.

Ocean and Coastal Research

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2023, Volume 71 Suppl. 3 elocation e23008

Abstract: En | Text: En | PDF: En

Abstract This work describes the circulation over the continental slope and the São Paulo Plateau in the Santos Basin during the SANSED winter 2019 survey. The cruise consisted of four legs in the period between June, 11 and August, 03 2019. The observed circulation is dominated by the Atlantic southwestern boundary current regime and remotely-generated anticyclones and cyclones. The former is composed by the Brazil Current, the Intermediate Western Boundary Current and their mesoscale meanders; the latter are 300km vortical rings with origin in the eastern side of the South Atlantic Basin. A Lagrangian scheme applied over satellite altimeter maps indicate that the origin of these rings is primarily the Cape Basin of South Africa. The interaction between the boundary currents, their cyclonic meanders, and the anticyclonic rings is complex, and varies widely. During the SANSED winter 2019 survey period, three anticyclones interacted with the Brazil Current, instabilizing it, forming dipoles with the current cyclonic meanders, leading to their downstream propagation. Ancienter cyclonic eddies within Santos Basin may interfere with the propagation of the large anticyclones further south. In addition, the continuous arrival of remotely-originated anticyclones, the larger portion over the São Paulo Plateau presented a tendency of counter-clockwise circulation during the whole cruise period.

https://doi.org/10.1590/2675-2824071.2206icas

A vertical-mode extrapolation scheme applied to the Brazil Current domain: quasi-synoptic scenarios verticalmode vertical mode domain quasisynoptic quasi synoptic
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Amorim, João P. M.

; Silveira, Ilson C. A. da

; Borges-Silva, Milton

; Souza-Neto, Pedro W. M.

; Belo, Wellington C.

; Lazaneo, Cauê Z.

; Bernardo, Piero S.

; Dottori, Marcelo

; Martins, Renato P.

; Moreira, Daniel L.

Ocean and Coastal Research

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2022, Volume 70 Suppl. 1 elocation e22055

Abstract: En | Text: En | PDF: En

Abstract The Brazil Current (BC) is a western boundary current, with an average vertical extension of 500 m, which occupies the southwestern margin of Atlantic Ocean. Recently, the South Brazil Bight - SBB (23º S - 28º S) has been intensively explored by the oil and gas industries, which brought a high demand in operational oceanography and ocean state monitoring. In this study we present a new technique based on the vertical dynamic modes of oscillation, to extrapolate velocity profiles in the SBB, with potential applications to data acquired by Vessel Mounted Acoustic Doppler Current Profilers (VMADCP). Using four quasi-synoptic crosssectional velocity data, acquired by Lowered Acoustic Doppler Current Profilers (LADCP), we observed that the mean circulation of this region can be characterized as a 2-dynamical mode system. This mean circulation is mainly dominated at surface by the BC and at intermediate levels by the Intermediate Western Boundary Current (IWBC), which flows northward. Furthermore, observed mesoscale vortical features in the SBB, such as eddies and meanders, are shown to be primarily barotropic-mode dominated. In our extrapolation methodology, the use of an independent set of velocity time series obtained by four moorings has shown to be a valid way for obtaining the relative contribution of each dynamical mode in the velocity field in the SBB. Normalized mean squared errors below 10% and radar diagrams show that the presented methodology was able to reproduce the main dynamic features observed by LADCP transects. Also, with this technique, we extrapolated three VMADCP sections and the results agreed with previous observations. (BC current 50 m Ocean Recently 23º º industries monitoring oscillation VMADCP. . (VMADCP) quasisynoptic quasi synoptic LADCP, , (LADCP) 2dynamical 2 system IWBC, IWBC (IWBC) northward Furthermore meanders barotropicmode barotropic 10 transects Also observations 5 (VMADCP (LADCP (IWBC 1

https://doi.org/10.1590/2675-2824070.22141jpma

Immature life cycle of laboratory-reared Phylloicus elektoros and Phylloicus amazonas (Trichoptera: Calamoceratidae) from a central Amazonian stream
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MARTINS, Renato Tavares

; SOARES, Kleicy Maciel

; HAMADA, Neusa

Acta Amazonica

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mar 2021, Volume 51 N. 1 Pages 67 - 70

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Nós criamos massas de ovos dos tricópteros Phylloicus amazonas (n = 2) e Phylloicus elektoros (n = 7) coletadas no campo até a fase adulta. A mediana do tempo de desenvolvimento do primeiro instar larval ao adulto foi de 229 dias para P. amazonas e 275 dias para P. elektoros, incluindo o tempo de desenvolvimento pupal (mediana de 13.5 e 16 dias, respectivamente). Fragmentadores têm sido frequentemente usados em estudos relacionados ao processamento de matéria orgânica em ecossistemas aquáticos. As informações biológicas fornecidas neste estudo podem ser úteis para o planejamento de estudos experimentais em campo ou em condições de laboratório.

ABSTRACT We reared field-collected egg masses of the caddisflies Phylloicus amazonas (n = 2) and Phylloicus elektoros (n = 7) to adulthood. First instar larvae of both species hatched up to five days after field collection. Median development time from first larval instar to adult was 229 days for P. amazonas and 275 for P. elektoros, including the pupal development time (median of 13.5 and 16 days, respectively). Shredder organisms have been used frequently in studies related to organic matter processing in freshwater ecosystems. The biological information reported in here may be useful for the design of experimental studies in the field or under laboratory conditions.

https://doi.org/10.1590/1809-4392202003861 385 downloads

Can we expect similar behavior among CuNiTi 35°C wires?
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GONZAGA, Ariane Salgado

; GONZAGA, David Salgado

; SIMPLÍCIO, Hallissa

; MARTINS, Renato Parsekian

; GALVÃO, Marília Regalado

; CALDAS, Sergei Godeiro Fernandes Rabelo

Dental Press Journal of Orthodontics

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2021, Volume 26 N. 2 elocation e211945

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: O presente artigo teve como objetivo verificar as propriedades termodinâmicas, mecânicas e químicas de fios CuNiTi 35°C comerciais. Métodos: Foram utilizados 40 arcos termodinâmicos pré-contornados de cobre-níquel-titânio de 0,017” x 0,025” e temperatura Af de 35°C. Oito fios de cinco fabricantes diferentes (American Orthodontics® [G1], Eurodonto® [G2], Morelli® [G3], Ormco® [G4] e Orthometric® [G5]) foram submetidos a medições de suas secções transversais, testes de tração, MEV-EDS e calorimetria diferencial (DSC). Foram utilizados testes paramétricos (One-way ANOVA e pós-teste de Tukey), com nível de significância de 5%, e foi realizado o teste do coeficiente de correlação de Pearson entre a temperatura Af e os elementos químicos dos fios. Todos os testes das amostras e análises estatísticas foram duplo-cegos. Resultados: Todos os fios apresentavam dimensões padronizadas (0,017” x 0,025”) e comportamento superelástico, com forças médias de platô de G1 = 36,49 N; G2 = 27,34 N; G3 = 19,24 N; G4 = 37,54 N; e G5 = 17,87 N. As médias de Af foram: G1 = 29,40°C, G2 = 29,13°C e G3 = 31,43°C, com p> 0,05 entre si. G4 (32,77°C) e G5 (35,17°C) apresentaram diferenças estatisticamente significativas entre si e entre os demais grupos. Todas as amostras apresentaram Ni, Ti, Cu e Al em diferentes concentrações. Conclusões: A concentração química dos elementos que compõem a liga influenciou significativamente as propriedades termodinâmicas e mecânicas.

ABSTRACT Objective: This paper aims to verify the thermodynamic, mechanical and chemical properties of CuNiTi 35ºC commercial wires. Methods: Forty pre-contoured copper-nickel-titanium thermodynamic 0.017 x 0.025-in archwires with an Af temperature of 35°C were used. Eight wires from five different manufacturers (American Orthodontics® [G1], Eurodonto® [G2], Morelli® [G3], Ormco® [G4] and Orthometric® [G5]) underwent cross-sectional dimension measurements, tensile tests, SEM-EDS and differential scanning calorimetry (DSC) tests. Parametric tests (One-way ANOVA and Tukey post-test) were used, with a significance level of 5%, and Pearson’s correlation coefficient test was performed between the Af and chemical elements of the wires. All sample tests and statistical analyses were double-blinded. Results: All wires presented standard dimensions (0.017 x 0.025-in) and superelastic behavior, with mean plateau forces of: G1 = 36.49N; G2 = 27.34N; G3 = 19.24 N; G4 = 37.54 N; and G5 = 17.87N. The Af means were: G1 = 29.40°C, G2 = 29.13°C and G3 = 31.43°C, with p>0.05 relative to each other. G4 (32.77°C) and G5 (35.17°C) presented statistically significant differences between each other and among the other groups. All samples presented Ni, Ti, Cu and Al in different concentrations. Conclusions: The chemical concentration of the elements that compose the alloy significantly influenced the thermodynamic and mechanical properties.

https://doi.org/10.1590/2177-6709.26.2.e211945.oar 164 downloads

Influence of psychosocial factors on the effectiveness of infertility treatments
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Pereira, Beatriz Sá

; Martins, Renato Silva

; Brito, Cristina Batista

; Pereira, Paulo Almeida

Acta Obstétrica e Ginecológica Portuguesa

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dec 2020, Volume 14 N. 4 Pages 208 - 216

Abstract: En | Text: En | PDF: En

Abstract Overview and Aims: Infertility is a rising problem in our society, with an increasing prevalence in the past years, resulting of an interaction of multifactorial causes, with great demand and personal suffering, being imperative to adopt an integrated view where physiology is intimately related to social and psychological processes. This study aims to identify the factors that contribute to the effectiveness of infertility treatments and overall outcomes of pregnancy and birth, with a special focus on the psychosocial component. Study Design and Population: This is a retrospective, descriptive and causal study of 278 infertile couples followed from 2015 to 2018. Methods: Data was collected on the causes of infertility, the treatments performed, and their effectiveness. The aim was to cross these data with clinically relevant psychological symptoms, through Brief Symptom Inventory (BSI) and Fertility’s Problem Inventory (FPI), in order to assess the stress inherent to their condition. Results: Emotional disorders are significantly more prevalent in women (p<0.05), as well as social and sexual concerns. The Need for parenthood and the Rejection of childfree lifestyle are the problems that most concern both elements of the couple. Conclusions: It was found that the couple's psychosocial component has an influence on the infertility’s treatment process, with an impact on its outcome. Symptoms such as Depression, Hostility and Phobic anxiety were higher in women who did not become pregnant after the treatment, as well as in men. Results were even more enlightening regarding pregnancy. For women, somatization is related to abortion (p<0.05), as well as most symptoms of BSI; whereas for men, sexual and relationship concerns are associated with male etiology and less likelihood to give birth.

183 downloads

10.

Characterization of adverse drug events identified by trigger in Brazilian pediatric inpatients
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Martins, Renato Rocha

; Lopes, Flavio Marques

Jornal de Pediatria

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jun 2020, Volume 96 N. 3 Pages 393 - 401

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever a frequência e as características dos eventos adversos a medicamentos em pacientes pediátricos internados em um hospital universitário terciário brasileiro. Métodos: Foi realizado um estudo transversal por meio da análise retrospectiva e manual de prontuários de 240 internações pediátricas para identificar eventos adversos a medicamentos utilizando 17 rastreadores. Quando foram identificados rastreadores no prontuário, os analistas investigaram extensivamente o prontuário para decidir a respeito da existência de um evento. O consenso sobre a ocorrência do evento foi obtido em reunião com uma equipe de profissionais da saúde. Os eventos foram classificados por categoria de dano e os medicamentos foram classificados de acordo com a Classificação Anatômica Terapêutico-Química. Os pacientes que sofreram eventos adventos foram comparados aos que não apresentaram eventos adversos, com o teste qui-quadrado e o teste U de Mann-Whitney. Resultados: Verificou-se um total de 62 eventos adversos e 18,8% dos pacientes apresentaram ao menos evento. As taxas de eventos adversos foram de 25,83 por 100 internações, 20,27 por 1.000 pacientes/dia, 25,94 por 1.000 medicamentos e 2,12 por 1.000 doses de medicamentos. Todos os eventos encontrados foram classificados como dano temporário e os medicamentos cardiovasculares foram frequentemente associados aos eventos. Grupos de pacientes com e sem eventos apresentaram diferenças (p < 0,05) em relação ao tempo de internação, número e doses de medicamentos. Conclusão: O uso de rastreadores demonstrou sua utilidade no contexto pediátrico ao identificar danos. As taxas de eventos adversos foram maiores do que as taxas de estudos anteriores, porém a categoria de dano foi menor que em outros estudos. Este estudo possibilita a medição dos eventos adversos a fim de definir estratégias para minimizar ou reduzir os danos.

Abstract Objective: To describe the frequency and characteristics of adverse drug events in pediatric inpatients in a Brazilian tertiary teaching hospital. Methods: A cross-sectional study was conducted by retrospective and manual chart review of 240 pediatric admissions to identify adverse drug events using 17 triggers. When triggers were detected in the chart, reviewers investigated the chart in depth to decide whether an event occurred. Consensus about the occurrence of the event was obtained in meeting with a healthcare team. Events were classified by harm category and drugs were classified according to the Anatomical Therapeutic Chemical Classification. Patients who had suffered were compared to those who had not experienced events using the chi-squared test and the Mann-Whitney U test. Results: A total of 62 adverse events were found, and 18.8% of the patients had at least one event. Adverse events rates were 25.83 per 100 admissions, 20.27 per 1000 patient-days, 25.94 per 1000 drugs, and 2.12 per 1000 drug doses. All events found were classified as temporary harm, and cardiovascular drugs were most frequently related to events. Groups of patients with and without event were segregated (p < 0.05) by the length of stay, number of drugs, and drug doses. Conclusion: The use of triggers demonstrated its utility in a pediatric setting by identifying harm. Adverse events rates were found to be higher than those of previous studies, but the harm rate was lower than other studies. This study enables the measurement of adverse events in order to define strategies to mitigate or reduce harm.

https://doi.org/10.1016/j.jped.2018.12.009 661 downloads

11.

The Brazilian Portuguese version of the Pediatric Trigger Toolkit is applicable to measure the occurrence of adverse drug events in Brazilian pediatric inpatients
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Martins, Renato Rocha

; Bessa, Gabriela Guimarães

; Lopes, Flavio Marques

Jornal de Pediatria

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feb 2019, Volume 95 N. 1 Pages 61 - 68

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever o processo de tradução, adaptação e validação para o português do Pediatric Trigger Toolkit: Measuring Adverse Drug Events in the Children's Hospital. Métodos: O processo de validação do instrumento de pesquisa foi realizado em 5 etapas: (I) tradução do inglês para o português por dois tradutores independentes; (II) síntese das versões traduzidas; (III) adaptação dos rastreadores para realidade brasileira por meio do método Delphi modificado, em duas rodadas; (IV) aplicação do instrumento de pesquisa na revisão de 240 internações de 2014; e (V) retrotradução do português para o inglês. Resultados: A etapa de tradução resultou em duas versões traduzidas, que foram sintetizadas de forma a obter equivalência ao contexto cultural brasileiro. O processo de adaptação do instrumento de pesquisa possibilitou a inclusão e adaptação dos rastreadores, bem como a exclusão de rastreadores segundo consenso obtido entre os especialistas na etapa Delphi. O valor preditivo positivo do instrumento de pesquisa foi de 13,51% e o rastreador anti-histamínico foi o que apresentou maior valor preditivo positivo. Conclusão: O instrumento de pesquisa pode ser utilizado para rastrear a ocorrência de eventos adversos a medicamentos em pacientes pediátricos nos hospitais brasileiros. Apesar das adaptações realizadas, rastreadores que não foram identificados ou com baixo valor preditivo positivo podem indicar, ainda, a necessidade de modificações. Entretanto, mais estudos são necessários antes de modificar ou excluir algum rastreador.

Abstract Objective: To describe the process of translation, adaptation, and validation of the Brazilian Portuguese version of the Pediatric Trigger Toolkit: Measuring Adverse Drug Events in the Children's Hospital. Methods: The validation process for the research instrument was carried out in five steps: (I) translation from English into Brazilian Portuguese by two independent translators; (II) synthesis of the translated versions; (III) adaptation of the triggers to the Brazilian context using a modified Delphi method carried out in two rounds; (IV) application of the research instrument in the review of 240 hospitalizations during 2014; and (V) back-translation from Brazilian Portuguese to English. Results: The translation step resulted in two versions, which were then synthesized to obtain equivalence within the Brazilian cultural context. The process of adapting the research instrument allowed the inclusion and adaptation of some triggers, as well as the exclusion of others, based on the consensus reached among experts during the Delphi step. The positive predictive value of the research instrument was 13.51%, and the antihistamine trigger presented the highest positive predictive value. Conclusion: The research instrument can be used to track the occurrence of adverse drug events in pediatric patients in Brazilian hospitals. Despite the adjustments made, triggers that were not identified or that had low positive predictive value can suggest the need for additional changes. However, more studies are needed before modifying or removing a trigger.

https://doi.org/10.1016/j.jped.2017.10.009 1178 downloads

12.

A EXPANSÃO PAULISTA EM AFONSO DE TAUNAY E SÉRGIO BUARQUE DE HOLANDA: REFLEXÕES E TRAJETÓRIAS
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Schneider, Alberto Luiz

; Martins, Renato

Revista de História (São Paulo)

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2019, N. 178 elocation a01018

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O artigo discute as relações de proximidade e distância intelectual e institucional entre os historiadores Afonso de Taunay e Sérgio Buarque de Holanda. Um e outro, em períodos diferentes, engajaram-se na produção historiográfica acerca da expansão paulista no período colonial. Como se sabe, o chamado "bandeirismo" foi um dos mais importantes temas da historiografia brasileira - particularmente da historiografia paulista - na primeira metade do século XX. Taunay interpretou o fenômeno como um capítulo da construção do território e da própria nacionalidade brasileira. Sérgio Buarque compreendeu a expansão paulista a partir do apresamento indígena para as lavouras dos campos de Piratininga. A despeito das diferenças teóricas e metodológicas, as relações entre os dois historiadores foi intensa. Não menos importante, interessa ao artigo observar a inserção institucional dos historiadores em questão. Ambos, em períodos diversos, dirigiram o Museu Paulista e ocuparam a cadeira de História da Civilização Brasileira na Universidade de São Paulo.

Abstract This article discusses the intellectual and institutional relations of proximity and distance between the historians Afonso de Taunay and Sérgio Buarque de Holanda. Both of them, at different periods of time, dedicated themselves to historiographical production of the paulista expansion in the colonial period. The so-called bandeirismo was one of the most important themes of Brazilian historiography - in particular of the paulista historiography - in the first half of the 20th century. Taunay interpreted the phenomenon as a chapter of the territory construction and of the Brazilian nationality itself. Sérgio Buarque saw the paulista expansion from the indigenous captivity for the agriculture lands in Piratininga. Despite the theoretical and methodological differences, the relations between the two historians were intense. It is also of interest to this article to observe the institutional context of the historians in question. Both, in different periods of time, were directors of the Paulista Museum and occupied the chair of History of the Brazilian Civilization at the University of São Paulo.

https://doi.org/10.11606/issn.2316-9141.rh.2019.142456 596 downloads

13.

An interview with Giorgio Fiorelli
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Fiorelli, Giorgio

; Linhares, Gidalti Bueno

; Sakima, Maurício Tatsuei

; Martins, Renato Parsekian

; Oliveira, Wislei de

Dental Press Journal of Orthodontics

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oct 2018, Volume 23 N. 5 Pages 24 - 38

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/2177-6709.23.5.024-038.int 2436 downloads

14.

The dynamics of energy metabolism in the tick embryo
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Martins, Renato

; Ruiz, Newton

; Fonseca, Rodrigo Nunes da

; Vaz Junior, Itabajara da Silva

; Logullo, Carlos

Revista Brasileira de Parasitologia Veterinária

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sep 2018, Volume 27 N. 3 Pages 259 - 266

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O carrapato bovino Rhipicephalus (B.) microplus é um ectoparasita capaz de transmitir diversos patógenos, sendo responsável por grandes perdas na pecuária pelos danos causados ao gado. Atualmente, muitos estudos têm negligenciado fases importantes do ciclo de vida deste parasita, como a fase embrionária. A embriogênese é classicamente descrita como um processo que demanda um consumo de energia, possibilitando a proliferação celular, diferenciação e crescimento. Além disso, em artrópodes, o estágio da embriogênese é caracterizado pela mobilização de metabolitos de origem materna para o desenvolvimento de novos tecidos e órgãos. A ressíntese de glicogênio no final da embriogênese tem sido descrita em diversas espécies de artrópodes, sendo considerada um indicador de integridade do embrião. No caso do R. (B.) microplus a ressíntese de glicogênio é sustentada pela degradação de proteínas durante a gliconeogênese, no terço final da embriogênese. Apesar dos recentes avanços, no estudo molecular e do metabolismo energético, os mecanismos envolvidos na dinâmica da utilização de diferentes substratos energéticos durante a embriogênese do carrapato R. (B.) microplus ainda é pouco entendido. Diante deste panorama, estudos que descrevam a regulação destes mecanismos e da associação do metabolismo de carboidratos com a transição materno zigótica, pode auxiliar na busca de novos alvos para o desenvolvimento de novos acaricidas e outras intervenções para o controle infestações de R. (B.) microplus.

Abstract The cattle tick Rhipicephalus (Boophilus) microplus is an ectoparasite capable of transmitting a large number of pathogens, causing considerable losses in the cattle industry, with substantial damage to livestock. Over the years, important stages of its life cycle, such as the embryo, have been largely ignored by researchers. Tick embryogenesis has been typically described as an energy-consuming process, sustaining cell proliferation, differentiation, and growth. During the embryonic stage of arthropods, there is mobilization of metabolites of maternal origin for the development of organs and tissues of the embryo. Glycogen resynthesis in late embryogenesis is considered as an effective indicator of embryonic integrity. In the cattle tick R.(B. (B.) microplus, glycogen resynthesis is sustained by protein degradation through the gluconeogenesis pathway at the end of the embryonic period. Despite recent advancements in research on tick energy metabolism at the molecular level, the dynamics of nutrient utilization during R. (B.) microplus embryogenesis is still poorly understood. The present review aims to describe the regulatory mechanisms of carbohydrate metabolism during maternal-zygotic transition and identify possible new targets for the development of novel drugs and other control measures against R. (B.) microplus infestations.

https://doi.org/10.1590/s1984-296120180051 1253 downloads

15.

Welding strength of NiTi wires
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Mesquita, Tatyane Ribeiro

; Martins, Lídia Parsekian

; Martins, Renato Parsekian

Dental Press Journal of Orthodontics

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jun 2018, Volume 23 N. 3 Pages 58 - 62

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: identificar a potência mais adequada para solda elétrica em três marcas comerciais de fios de níquel-titânio (NiTi). Métodos: noventa pares de fios ortodônticos de NiTi, de dimensões 0,018” e 0,017” × 0,025’’, foram soldados por resistência elétrica e distribuídos em três grupos: GI (Orthometric, Marília, São Paulo, Brasil), GII (3M, São José do Rio Preto, São Paulo, Brasil) e GIII (GAC, Yorque, Pensilvânia, Estados Unidos). Cada grupo foi dividido em subgrupos de cinco pares de fios soldados com diferentes níveis de potência. Nos GI e GII, os fios foram soldados com níveis de potência de 2.5, 3, 3.5, 4, 4.5 e 5; enquanto no GIII as potências utilizadas foram de 2.5, 3, 3.5 e 4. Os pares de fios foram submetidos a um teste de tração até sua ruptura, com registro das forças máximas. Análises de variância (ANOVA) e testes post-hoc foram realizados para determinar qual subgrupo, dentro de cada grupo, obteve a maior força de resistência. Resultados: a potência 2.5 exibiu a menor resistência à ruptura para todos os grupos (43,75 N para o GI; 28,41 N para o GII e 47,57 N para o GIII). A potência 4 mostrou maior resistência à ruptura nos GI e GII (97,90 N e 99,61 N, respectivamente), enquanto no GIII (79,28 N) foi a potência 3.5. Conclusões: os níveis de potência mais adequados variaram para as marcas comerciais, sendo identificados como 4 para Orthometric e 3M, e 3.5 para GAC.

ABSTRACT Objective: To identify the appropriate power level for electric welding of three commercial brands of nickel-titanium (NiTi) wires. Methods: Ninety pairs of 0.018-in and 0.017 × 0.025-in NiTi wires were divided into three groups according to their manufacturers - GI (Orthometric, Marília, Brazil), GII (3M OralCare, St. Paul, CA) and GIII (GAC,York, PA) - and welded by electrical resistance. Each group was divided into subgroups of 5 pairs of wires, in which welding was done with different power levels. In GI and GII, power levels of 2.5, 3, 3.5, 4, 4.5 and 5 were used, while in GIII 2.5, 3, 3.5 and 4 were used (each unit of power of the welding machine representing 500W). The pairs of welded wires underwent a tensile strength test on an universal testing machine until rupture and the maximum forces were recorded. Analysis of variance (ANOVA) and post-hoc tests were conducted to determine which subgroup within each brand group had the greatest resistance to rupture. Results: The 2.5 power exhibited the lowest resistance to rupture in all groups (43.75N for GI, 28.41N for GII and 47.57N for GIII) while the 4.0 power provided the highest resistance in GI and GII (97.90N and 99.61N, respectively), while in GIII (79.28N) the highest resistance was achieved with a 3.5 power welding. Conclusions: The most appropriate power for welding varied for each brand, being 4.0 for Orthometric and 3M, and 3.5 for GAC NiTi wires.

https://doi.org/10.1590/2177-6709.22.3.058-062.oar 333 downloads

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