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ABSTRACT Dopamine agonists are the first line of treatment for patients with symptomatic hyperprolactinemia due to prolactinomas and in those with idiopathic hyperprolactinemia. Treatment with these agents is effective in 80%-90% of the cases. Infertility treatment of patients with hyperprolactinemia is also carried out with dopamine agonists, aiming for the normalization of prolactin levels. The risk of symptomatic growth of prolactinomas during pregnancy is dependent on the tumor's size, duration of previous treatments, and prolactin levels. Notably, the corresponding risk is relatively low in cases of microprolactinomas (<5%). Remission of hyperprolactinemia occurs in about 30% of the patients after drug treatment and may also occur after pregnancy and menopause. The use of some drugs, such as antidepressants and antipsychotics, is a frequent cause of hyperprolactinemia, and managing this occurrence involves unique considerations. This position statement by the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and Brazilian Society of Endocrinology and Metabolism (SBEM) addresses the recommendations for measurement of serum prolactin levels and the investigations of symptomatic and asymptomatic hyperprolactinemia and drug-induced hyperprolactinemia in women. 80%90% 8090 80% 90% 80 90 80%-90 tumors tumor s size treatments Notably <5%. 5 <5% . (<5%) 30 menopause drugs antipsychotics considerations Febrasgo (Febrasgo SBEM (SBEM druginduced induced women 80%90 809 8 9 80%-9 <5 (<5% 3 80%9 80%- < (<5 (< (

https://doi.org/10.20945/2359-4292-2023-0504

Diagnosis of hyperprolactinemia in women: A Position Statement from the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and the Brazilian Society of Endocrinology and Metabolism (SBEM) women Febrasgo (Febrasgo SBEM (SBEM
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Glezer, Andrea

; Garmes, Heraldo Mendes

; Kasuki, Leandro

; Martins, Manoel

; Elias, Paula Condé Lamparelli

; Nogueira, Vania dos Santos Nunes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230502

Abstract: En | Text: En | PDF: En

ABSTRACT Hyperprolactinemia is a frequent cause of menstrual irregularity, galactorrhea, hypogonadism, and infertility. The most common etiologies of hyperprolactinemia can be classified as physiological, pharmacological, and pathological. Among pathological conditions, it is essential to distinguish prolactinomas from other tumors and pituitary lesions presenting with hyperprolactinemia due to pituitary stalk disconnection. Proper investigation considering clinical data, laboratory tests, and, if necessary, imaging evaluation, is important to identify the correct cause of hyperprolactinemia and manage the patient properly. This position statement by the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and Brazilian Society of Endocrinology and Metabolism (SBEM) addresses the recommendations for measurement of serum prolactin levels and the investigations of symptomatic and asymptomatic hyperprolactinemia and medication-induced hyperprolactinemia in women. irregularity galactorrhea hypogonadism infertility physiological pharmacological conditions disconnection data tests necessary evaluation properly Febrasgo (Febrasgo SBEM (SBEM medicationinduced medication induced women

https://doi.org/10.20945/2359-4292-2023-0502

Hyperprolactinemia in women: treatment women
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Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

; Rosa e Silva, Ana Carolina Japur

; Maciel, Gustavo Arantes Rosa

; dos Santos Nunes Nogueira, Vania

; Elias, Paula Condé Lamparelli

; Martins, Manoel

; Kasuki, Leandro

; Garmes, Heraldo Mendes

; Glezer, Andrea

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-FPS05

Abstract: En | Text: En | PDF: En

https://doi.org/10.61622/rbgo/2024fps05

Hyperprolactinemia in women: diagnostic approach women
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Glezer, Andrea

; Garmes, Heraldo Mendes

; Kasuki, Leandro

; Martins, Manoel

; Elias, Paula Condé Lamparelli

; Nogueira, Vania dos Santos Nunes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-FPS04

Abstract: En | Text: En | PDF: En

https://doi.org/10.61622/rbgo/2024fps04

Budget impact analysis of cabergoline for medical treatment of Cushing’s disease in Brazil Cushings Cushing s
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Silva, Lukas Fernando de Oliveira

; Galendi, Julia Simões Corrêa

; Martins, Manoel Ricardo Alves

; Nogueira, Vania dos Santos Nunes

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230311

Abstract: En | Text: En | PDF: En

ABSTRACT Objective The aim of this study was to estimate the budget impact of adding cabergoline to the Brazilian Unified Health System (SUS) formulary for the treatment of patients with Cushing’s disease (CD) who do not achieve disease control after transsphenoidal surgery. Materials and methods We conducted a budget impact analysis (BIA) from the perspective of the Brazilian SUS over a 5-year time horizon. We compared two scenarios: ketoconazole (Scenario 1) versus including cabergoline as a treatment option (Scenario 2). All analyses were conducted using Microsoft Excel. Uncertainty was explored in univariate sensitivity analyses. Results The total costs were BRL $25,596,729 for Scenario 1 and BRL $32,469,169 for Scenario 2. The budget impact of adding cabergoline to the formulary for CD treatment within the SUS would be BRL $6,091,036 over 5 years. On univariate analyses, variations in the rates of surgical failure and CD recurrence had the greatest potential to affect the final costs associated with cabergoline. Conclusions The estimated budget impact of adding cabergoline to the formulary for CD treatment within the Brazilian SUS would be about BRL $6 million. While cost savings cannot be expected, the budget impact of adding cabergoline would be lower than that of adding other treatment options for CD. (SUS Cushings Cushing s (CD surgery BIA (BIA 5year year horizon scenarios 2 . 2) Excel 25596729 25 596 729 $25,596,72 32469169 32 469 169 $32,469,16 6091036 6 091 036 $6,091,03 years $ million expected 2559672 59 72 $25,596,7 3246916 3 46 16 $32,469,1 609103 09 03 $6,091,0 255967 7 $25,596, 324691 4 $32,469, 60910 0 $6,091, 25596 $25,596 32469 $32,469 6091 $6,091 2559 $25,59 3246 $32,46 609 $6,09 255 $25,5 324 $32,4 60 $6,0 $25, $32, $6, $25 $32 $2 $3

https://doi.org/10.20945/2359-4292-2023-0311

Does Postpartum Hypopituitarism Influence the Craniofacial Pattern? A Case-Control Study with Sheehan’s Syndrome Patients
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Cavalcante, Davi de Sá

; Quidute, Ana Rosa Pinto

; Martins, Manoel Ricardo Alves

; Carvalho, Francisco Samuel Rodrigues

; Cid, Adília Mirela Pereira

; Silva, Paulo Goberlanio de Barros

; Aguiar, Andrea Silvia Walter de

; Ribeiro, Thyciana Rodrigues

; Costa, Fábio Wildson Gurgel

International journal of odontostomatology

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mar 2023, Volume 17 N. 1 Pages 38 - 45

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN: Este estudio tuvo como objetivo evaluar los aspectos morfológicos craneofaciales de los pacientes con síndrome de Sheehan (SHS). Se realizó un estudio observacional con 19 mujeres diagnosticadas con SHS y 19 controles asociados por edad y sexo. Se obtuvieron radiografías cefalométricas laterales y se analizaron 30 medidas lineales y angulares mediante el software Radiocef Studio 2. La edad media de los pacientes fue de 65,47 ± 10,19 años. Los principales hallazgos fueron proposición maxilar (52,63 %) y mandíbula (52,63 %) con respecto a la base del cráneo, prognatismo mandibular en 73,68 %, patrón de crecimiento profundo en 42,1 %, aumento del plano mandibular en 36,84 % y reducción de la altura facial anterior. El grupo SHS mostró diferencias estadísticamente significativas en SNB (p=0,026), N-Me (p=0,006), longitud del paladar blando (p=0,011) y Ena-Me (p<0,001) en comparación con los controles. El análisis de la puntuación de la desviación estándar reveló valores alterados en relación con las longitudes maxilares y mandibulares totales. El SHS mostró una morfología craneofacial alterada, caracterizada por prognatismo maxilomandibular, tipo braquifacial, aumento del plano mandibular y reducción de la longitud del velo del paladar. Este estudio informa hallazgos novedosos en SHS.

ABSTRACT: This study aimed to assess the craniofacial morphologic aspects of Sheehan’s syndrome (SHS) patients.An observational study was performed with 19 women diagnosed with SHS and 19 controls matched by age and sex. Lateral cephalometric radiographs were obtained, and 30 linear and angular measurements were analyzed using the Radiocef Studio 2 software. The mean age of patients was 65.47 ± 10.19 years. The main findings were propositioned maxilla (52.63 %) and mandible (52.63 %) relative to the cranial base, mandibular prognathism in 73.68 %, deep growth pattern in 42.1 %, increased mandibular plane in 36.84 %, and reduction in anterior facial height. The SHS group showed statistically significant differences in SNB (p=0.026), N-Me (p=0.006), soft palate length (p=0.011), and Ena-Me (p<0.001) in comparison with controls. The standard deviation score analysis revealed altered values in relation to total maxillary and mandibular lengths. SHS showed altered craniofacial morphology, characterized by maxillo- mandibular prognathism, brachyfacial type, increased mandibular plane, and reduction in soft palate length. This study reports novel findings in SHS.

Impact of the COVID-19 pandemic in the treatment of patients with acromegaly in a tertiary center: a wake-up call on the importance of telemedicine
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Nunes, Rafaela de Jesus

; Masullo, Lais Farias

; Lira, Matheus Zaian Rodrigues de Fonseca

; Leite, Cíntia Maria Gomes

; Gomes, Thierry Mendes

; Fontenele, Eveline Gadelha Pereira

; Quidute, Ana Rosa Pinto

; Martins, Manoel Ricardo Alves

Archives of Endocrinology and Metabolism

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dec 2022, Volume 66 N. 6 Pages 863 - 867

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The COVID-19 pandemic has profoundly disrupted health care worldwide. We aimed to evaluate the impact of the first COVID-19 wave on the treatment of our patients with acromegaly. Subjects and methods: A standard questionnaire was systematically applied to all patients and included questions on general health status, whether all laboratory workup had been done, common signs and symptoms of acromegaly, treatment adherence, and previous COVID-19 symptoms and diagnosis. Results: We attempted to contact 136 patients with acromegaly at regular follow-up at our institution and contacted 101 of them successfully. In all, 37% of the patients reported symptoms of acromegaly, which was more common among women. A total of 27 patients were lost to follow-up (including 19 who interrupted treatment during the pandemic) mainly for fear of becoming infected by the SARS-CoV-2. Of these, 24 resumed follow-up after our contact. Conclusions: The current COVID-19 pandemic has strongly impacted the follow-up of patients with acromegaly. Telemedicine can be an important tool to maintain regular treatment in the current or future pandemics.

https://doi.org/10.20945/2359-3997000000491

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism
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Garmes, Heraldo Mendes

; Boguszewski, César Luiz

; Miranda, Paulo Augusto Carvalho

; Martins, Manoel Ricardo Alves

; Silva, Silvia Regina Correa da

; Abucham Filho, Julio Zaki

; Musolino, Nina Rosa de Castro

; Vilar, Lucio

; Portari, Luiz Henrique Corrêa

; Gadelha, Mônica Roberto

; Kasuki, Leandro

; Naves, Luciana Ansaneli

; Czepielewski, Mauro Antônio

; Almeida, Tobias Skrebsky de

; Duarte, Felipe Henning Gaia

; Glezer, Andrea

; Bronstein, Marcello Delano

Archives of Endocrinology and Metabolism

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apr 2021, Volume 65 N. 2 Pages 212 - 230

Abstract: En | Text: En | PDF: En

ABSTRACT Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.

https://doi.org/10.20945/2359-3997000000335 625 downloads

Use of experimental design techniques for the optimization of the resin distillation process of Pinus elliottii
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Silva Júnior, Afonso Henrique da

; Nogueira, Arthur Doria

; Martins, Manoel Leonardo

; Lopes, Toni Jefferson

Ciência Florestal

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mar 2021, Volume 31 N. 1 Pages 252 - 270

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Nas últimas décadas, o setor de produtos de resina no Brasil está demonstrando uma perspectiva de demanda crescente para os produtores de goma de resina, o que exige avanços na parte técnica dos processos de extração e purificação. Este trabalho teve como objetivo analisar, através de técnicas de planejamento experimental, os processos de lavagem e destilação da oleorresina de Pinus elliottii. A resina natural foi coletada na região costeira do estado do Rio Grande do Sul, Brasil. Os resultados da etapa de lavagem revelaram que as interações lineares de segunda ordem foi o modelo empírico mais adequado para este estudo. Portanto, o teste ideal foi determinado com os seguintes fatores: temperatura de 50ºC, tempo de 20 min e 20% de terebentina utilizada para a diluição. Para o processo de destilação, o melhor modelo foi o linear sem interações, considerando a resposta do Valor Monetário (Real - R$) por 100 g de resina processada. Assim, determinou-se que a região ótima obteve os seguintes fatores: temperatura entre 156 e 170ºC e tempo entre 61 e 100 minutos. Portanto, o uso de técnicas de planejamento experimental permitiu propor ao produtor algumas alternativas no processamento de resina natural, o que consequentemente causou o aumento do valor agregado ao produto comercializado.

ABSTRACT In the last decades, the resin product sector in Brazil is demonstrating a growing demand perspective for resin gum producers, what requires advances in the technical part of the extraction and purification processes. This work aimed to analyze, through experimental design techniques, the washing and distillation processes of the Pinus elliottii oleoresin. The natural resin was collected in the coastal region of Rio Grande do Sul state, Brazil. The results of the washing step revealed that the linear with second-order interactions was the empirical model that best suited for this study. Therefore, the optimal test was determined with the following factors: temperature of 50ºC, time of 20 min, and 20% turpentine used for dilution. For the distillation process, the best model was the linear without interactions taking into account the Monetary Value (Real - R$) response per 100 g of processed resin. Thus, it was determined that the optimum region obtained the following factors: temperature between 156 and 170 ºC and time between 61 and 100 min. Therefore, the use of experimental design techniques enabled to propose some alternatives on the processing of natural resin to the producer, what consequently caused the increase in its added value to the marketed product.

https://doi.org/10.5902/1980509840346 1156 downloads

10.

Método de cálculo de velocidade de motocicleta com base na distância de projeção do motociclista
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Martins, Manoel José Rodrigues

; Oliveira, Alice Ferreira dos Santos de

; Oliveira, Luiz Alberto Martins de

; Gomes, Juliano de Andrade

Revista Brasileira de Ensino de Física

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2020, Volume 42 elocation e20200219

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O uso de motocicletas como um meio de transporte tem aumentado muito ultimamente; infelizmente, o número de acidentes envolvendo motociclistas também cresceu. Nesses casos, o papel do perito criminal é reconstruir a dinâmica do evento, devendo, entre outras coisas, determinar a velocidade dos veículos envolvidos. Este trabalho consiste na proposição de um método de cálculo de velocidades de motocicletas envolvidas em acidentes de trânsito nos casos em que ocorre a projeção do motociclista. Para isso, busca-se determinar a velocidade na qual o corpo do motociclista é projetado. No procedimento, a distância total de projeção é dividida em duas fases: voo e deslizamento. O cálculo do tempo de queda do corpo durante a fase de voo foi feito sem aproximações e, na fase de deslizamento, foi incluído o ângulo de inclinação do terreno. Após a obtenção da equação da velocidade de projeção do corpo do motociclista, é deduzida uma equação para o cálculo da velocidade desenvolvida pela motocicleta no instante da colisão. Por fim, considerando-se as margens de incertezas inerentes aos processos de medição das variáveis de entrada, foi empregado o método de Monte Carlo para analisar casos reais e avaliar o intervalo de confiança do resultado encontrado.

Abstract The use of motorcycles as a means of transport has intensified a lot lately; unfortunately, the number of accidents involving motorcyclists has also increased. In such cases, the role of the forensic scientist is to reconstruct the dynamics of the event, and must, among other things, determine the speed of the vehicles involved. This work consists of proposing a method for calculating the speed of motorcycles involved in traffic accidents in cases where the projection of the rider occurs. To do this, the aim is to determine the speed with which the rider's body is designed. In the procedure, the total projection distance is divided into two phases: flight and slip. The calculation of the body's fall time during the flight phase was made without approximations and, in the slip phase, the slope angle of the terrain was included. After obtaining the equation of the projection speed of the rider's body, an equation is deduced to calculate the speed developed by the motorcycle at the collision time. Finally, considering the uncertainty margins inherent to the measurement processes of the input variables, the Monte Carlo method was applied to analyze real cases and to evaluate the confidence interval of the result found.

https://doi.org/10.1590/1806-9126-rbef-2020-0219 1304 downloads

11.

O uso da estatística em grandes e médias empresas de autopeças no estado de São Paulo, Brasil
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Toledo, José Carlos de

; Lizarelli, Fabiane Letícia

; Borrás, Miguel Ángel Aires

; Martins, Manoel Fernando

Innovar

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dec 2018, Volume 28 N. 70 Pages 81 - 98

Resumen La utilización de enfoques de mejoría supone análisis y decisiones basadas en informaciones provenientes del análisis de datos, lo que tiene asociación directa con la utilización del Pensamiento Estadístico (PEst) y de Herramientas Estadísticas (HE). El artículo analiza el uso del PEst y HE, así como los beneficios percibidos en una muestra de grandes y medianas empresas de manufactura de repuestos del departamento de São Paulo, Brasil. Las empresas pertenecientes a esta industria adoptan enfoques de mejoría desde hace un tiempo relativamente mayor en comparación con otros sectores industriales y se espera que, mediante estos enfoques, se haya creado un ambiente de madurez en el uso de conceptos y HE. la investigación empírica se realizó por medio de un websurvey, y se obtuvo una muestra de 32 empresas, con la utilización de cuestionario contestado por gerentes de la calidad, producción o del área de mejoría. Pese el uso de diversos enfoques de mejoría, las empresas analizadas aún no han incorporado completamente los conceptos estadísticos y poseen dificultad en el uso de las herramientas, sobre todo las consideradas más complejas. El análisis multivariado de los datos evidenció que la conducta de las empresas en relación con la utilización de PEst y HE no es homogénea, e indicó grupos de empresas en distintos niveles de madurez en el uso y los beneficios percibidos.

Résumé L'utilisation d'approches d'amélioration implique une analyse et des décisions basées sur des informations provenant de l'analyse des données, qui ont un lien direct avec l'utilisation de la pensée statistique (PST) et des outils statistiques (OS). L'article analyse l'utilisation de la PST et des OS, ainsi que les avantages perçus dans un échantillon de grandes et moyennes entreprises de fabrication de pièces de rechange du département de São Paulo, au Brésil. Les entreprises appartenant à cette industrie adoptent des approches d'amélioration depuis un temps relativement plus long par rapport à d'autres secteurs industrieis, et on s'attend à ce que ces approches aient permis de créer un environnement mür dans l'utilisation des concepts et OS. La recherche empirique a été menée au moyen d'une enquête sur le Web. On a obtenu un échantillon de 32 entreprises à l'aide d'un questionnaire, auquel ont répondu des responsables de la qualité, de la production ou du domaine d'amélioration. Malgré l'utilisation de différentes approches en matière d'amélioration, les entreprises analysées n'ont pas encore totalement intégré les concepts statistiques et ont des difficultés à utiliser les outils, en particulier ceux considérés comme plus complexes. L'analyse multivariée des données a montré que le comportement des entreprises vis-à-vis de l'utilisation de la PST et des OS n'est pas homogène. Elle a montré également des groupes d'entreprises à différents niveaux de maturité dans l'utilisation et les avantages perçus.

Abstract The use of improvement approaches involves analysis and decision-making processes based on data and information analysis. This has a direct association with the use of Statistical Thinking and Statistical Tools. Therefore, this paper studies the use of statistical thinking and statistical tools, as well as the benefits perceived from their usage, in a sample of large and medium-sized companies in the manufacturing sector of spare-parts in São Paulo, Brazil. Companies belonging to this industry adopted improvement approaches long before other industrial sectors. Therefore, a mature environment for the use of concepts and statistical tools is expected from the adoption of such approaches. This empirical research was carried out through a web survey, obtaining a final sample of 32 companies. Quality, production or improvement managers of these companies were asked to answer a questionnaire. Results show that, despite the use of various improvement approaches, the studied companies have not fully incorporated statistical concepts and have difficulties using statistical tools, especially those considered as more complex. Multivariate analysis indicates that companies' behavior towards the use of both statistical thinking and tools is not homogeneous, and reveals groups of companies at different maturity levels in the use and perceived benefits.

Resumo A utilização de abordagens de melhoria supõe análises e decisões baseadas em informações provenientes da análise de dados, o que tem associação direta com a utilização do Pensamento Estatístico (PEst) e de Ferramentas Estatísticas (FE). O artigo analisa o uso do PEst e de FE, bem como os benefícios percebidos em uma amostra de empresas de grande e médio porte de manufatura de autopeças do estado brasileiro de São Paulo. As empresas pertencentes a essa indústria adotam abordagens de melhoria há um tempo relativamente maior em comparação a outros setores industriais e é esperado que, por meio dessas abordagens, tenha sido criado um ambiente com maturidade no uso de conceitos de FE. A pesquisa empírica foi realizada por meio de um websurvey, obtendo-se uma amostra de 32 empresas, com a utilização de questionário respondido por gerentes da qualidade, produção ou da área de melhoria. Apesar do uso de diversas abordagens de melhoria, as empresas analisadas ainda não incorporaram completamente os conceitos estatísticos e possuem dificuldade no uso das ferramentas, principalmente as consideradas mais complexas. A análise multivariada dos dados evidenciou que o comportamento das empresas em relação à utilização de PEst e de FE não é homogêneo, e indicou grupos de empresas em diferentes níveis de maturidade no uso e nos benefícios percebidos.

https://doi.org/10.15446/innovar.v28n70.74450 364 downloads

12.

Gestão do conhecimento: tipologia a partir dos fatores contextuais da organização
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GONZALEZ, Rodrigo Valio Dominguez

; MARTINS, Manoel Fernando

; MELO, Tatiana Massaroli

Transinformação

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aug 2018, Volume 30 N. 2 Pages 249 - 266

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A gestão do conhecimento como prática capaz de trazer vantagem competitiva e inovação às firmas é um consenso entre os pesquisadores. A gestão do conhecimento é alicerçada por fatores contextuais, desenvolvidos de forma distinta pelas organizações. Dessa forma, esta pesquisa tem o propósito de identificar uma tipologia quanto ao desenvolvimento desses fatores contextuais. O estudo considera cinco constructos organizacionais relacionados à gestão do conhecimento: recursos humanos, trabalho em equipe, cultura organizacional, estrutura organizacional e desenvolvimento e absorção de conhecimento. A pesquisa é desenvolvida a partir de um survey em 78 empresas do setor automobilístico. A análise de dados é baseada nas técnicas estatísticas de análise fatorial exploratória, que desdobra as variáveis mensuráveis em fatores latentes, análise de cluster, que identifica agrupamentos de empresas, e análise discriminante, que valida a diferença estatística entre os clusters identificados. Os resultados apontam a existência de quatro agrupamentos distintos quanto à pratica da gestão do conhecimento, denominados de “Empresas Inovadoras”, “Empresas Exploradoras”, “Empresas Explotatoras” e “Empresas Retardatárias”.

Abstract Knowledge Management as a practice that returns competitive advantage and innovation to firms is a consensus among researchers. The Knowledge Management is supported by contextual factors developed differently by organizations. Thus, the aim of this research was to identify a typology for the development of these contextual factors. The study considers five organizational constructs related to Knowledge Management: human resources, teamwork, organizational culture, organizational structure, and knowledge development and absorption. The research was developed from a survey of 78 companies in the automotive sector and data analysis was based on the statistical techniques of exploratory factor analysis, which combines measurable variables into latent factors, cluster analysis, which identifies clusters of companies, and discriminant analysis, which validates the statistical difference between the clusters identified. The results point to four different clusters regarding the practice of Knowledge Management: “Innovative Companies”, “Explorative Companies”, “Exploitative Companies” and “Companies Laggards”.

https://doi.org/10.1590/2318-08892018000200009 3661 downloads

13.

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vilar, Lucio

; Abucham, Julio

; Albuquerque, José Luciano

; Araujo, Luiz Antônio

; Azevedo, Monalisa F.

; Boguszewski, Cesar Luiz

; Casulari, Luiz Augusto

; Cunha Neto, Malebranche B. C.

; Czepielewski, Mauro A.

; Duarte, Felipe H. G.

; Faria, Manuel dos S.

; Gadelha, Monica R.

; Garmes, Heraldo M.

; Glezer, Andrea

; Gurgel, Maria Helane

; Jallad, Raquel S.

; Martins, Manoel

; Miranda, Paulo A. C.

; Montenegro, Renan M.

; Musolino, Nina R. C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Silva, Cíntia M. S.

; Viecceli, Camila

; Bronstein, Marcello D.

Archives of Endocrinology and Metabolism

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mar 2018, Volume 62 N. 2 Pages 236 - 263

Abstract: En | Text: En | PDF: En

ABSTRACT Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience.

https://doi.org/10.20945/2359-3997000000032 36158 downloads

14.

O Processo de Gestão do Conhecimento: uma pesquisa teórico-conceitual
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Gonzalez, Rodrigo Valio Dominguez

; Martins, Manoel Fernando

Gestão & Produção

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jun 2017, Volume 24 N. 2 Pages 248 - 265

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: A gestão do Conhecimento (GC) é um tema que vem despertando o interesse de muitos pesquisadores nas últimas décadas, sendo grande parte das contribuições orientadas por etapas, denominadas processo de GC. Por se tratar de um tema abrangente, as publicações sobre o processo de GC apresentam contribuições multidisciplinares e, desta forma, esta pesquisa tem por objetivo conceituar este processo, analisando as principais abordagens que orientam o estudo de cada etapa, e, também, levantar as principais publicações que tratam do tema, classificando-as quanto à sua área de contribuição. Para alcançar estes objetivos, este artigo é orientado por uma pesquisa teórico-conceitual, na qual foram estudados 71 artigos. Os resultados desta pesquisa apontam que o processo de GC é constituído de quatro etapas: aquisição, armazenamento, distribuição e utilização do conhecimento. Na fase de aquisição, as temáticas estudadas são aprendizagem organizacional, absorção de conhecimento, processo criativo e transformação do conhecimento. Na fase de armazenamento, as contribuições tratam do indivíduo, organização e tecnologia da informação, enquanto na fase de distribuição os estudos concentram-se nas temáticas contato social, comunidade de prática e compartilhamento via tecnologia de informação. E, por fim, na fase de utilização, são abordados os temas forma de utilização, capacidade dinâmica e recuperação e transformação do conhecimento.

Abstract: Knowledge Management (KM) is a subject that has aroused the interest of many researchers in the last decade, being great part of contributions driven by steps, named KM process. Because it is an embracing theme, publications about KM process have multidisciplinary contributions and, thus, this research aims to conceptualize this process, analyzing the main approach that guides the study of each stage, and also, to raise the main publications on the subject, classifying them as to their contribution area. To reach these goals, this article is oriented by a theoretical-conceptual research, in which 71 articles were studied. The results indicate that the KM process consists of four stages: acquisition, storage, distribution, and use of knowledge. In the acquisition phase, the studied themes are organizational learning, knowledge inception, creative process and knowledge transformation. In the storage phase, the contributions deal with a person, an organization and information technology, while in the distribution phase the studies concentrate in social contact themes, practice community and sharing via information technology. And, finally, in the use phase, we address the form of use, dynamic capacity and retrieval and knowledge transformation.

https://doi.org/10.1590/0104-530x0893-15 123847 downloads

15.

Evaluation of QuEChERS Sample Preparation for Determination of Avermectins Residues in Ovine Muscle by HPLC-FD and UHPLC-MS/MS
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Bandeira, Nelson M. G.

; Ribeiro, Lucila C.

; Rizzetti, Tiele M.

; Martins, Manoel L.

; Adaime, Martha B.

; Zanella, Renato

; Prestes, Osmar D.

Journal of the Brazilian Chemical Society

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may 2017, Volume 28 N. 5 Pages 878 - 886

Abstract: En | Text: En | PDF: En

A fast and sensitive method using high performance liquid chromatography-fluorescence detection (HPLC-FD) and ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) was developed and validated for the determination of avermectins residues in ovine muscle samples. QuEChERS (quick, easy, cheap, effective, rugged and safe) sample preparation based on acetonitrile extraction followed by partitioning with NaCl and Na2SO4 and dispersive solid-phase extraction (d-SPE) clean-up with C18 was applied. Na2SO4 was used instead of MgSO4 due to lower amounts of co-extractives in the final extract. The procedure was validated according to the Commission Decision 2002/657/EC. The method showed determination coefficients (r2) higher than 0.99, recoveries between 93.2 and 124.3% for spike levels between 0.5 and 2.0 times the maximum residues limit (MRL) values. The repeatability and intermediate precision RSD values ranged from 1 to 19%. Decision limits (CCα) and detection capabilities (CCβ) ranged from 10.7 to 59.4 µg kg-1 and 11.4 to 68.8 µg kg-1, respectively. Method performance was successfully evaluated by analyzing real samples and proficiency test with a z-score in the range of ±1.

https://doi.org/10.21577/0103-5053.20160240 1590 downloads

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