ABSTRACT Purpose: To evaluate the presence of congenital hypertrophy of the retinal pigment epithelium in a large family affected by familial adenomatous polyposis and identify the causative mutation in the adenomatous polyposis coli gene. Thus, we aimed to determine the significance of congenital hypertrophy of the retinal pigment epithelium as a phenotypic marker of the disease. Methods: A family consisting of 95 individuals was evaluated. Among these, 45 individuals were randomly selected by convenience sampling method to undergo ophthalmological evaluation. A funduscopic exam, including slit lamp and indirect ophthalmoscopy, were performed in the selected patients. In those with retinal lesions, a retinography was obtained. The adenomatous polyposis coli gene was sequenced in one affected family member to identify the pathogenic mutation. Once the variant was identified, six undiagnosed family members were tested for the mutation via capillary electrophoresis sequencing. Results: Congenital hypertrophy of the retinal pigment epithelium was observed in 13 (28.9%) of the 45 individuals evaluated. Of these, nine patients were confirmed to have familial adenomatous polyposis (via colonoscopy or molecular testing). However, four patients had not been investigated. Of the 32 (71.1%) family members without the lesion, 14 did not have familial adenomatous polyposis and 18 were yet to be evaluated. The lesions were bilaterally present and exhibited a peculiar fish-tail shape in all the evaluated individuals. Adenomatous polyposis coli gene sequencing revealed a pathogenic variant c.4031del. (Ser1344*), in heterozygosity (49.27%), in exon 16. Conclusions: The study findings confirmed the significance of congenital hypertrophy of the retinal pigment epithelium as a phenotypic marker for familial adenomatous polyposis. Furthermore, it is an effective first-line screening method for at risk family members of such patients. The novel mutation identified in our study participants, which is yet to be described in the literature, causes an aggressive form of the disease. Purpose Thus disease Methods 9 these 4 evaluation exam ophthalmoscopy obtained Results 1 28.9% 289 28 (28.9% testing. testing . testing) However investigated 3 71.1% 711 71 (71.1% lesion fishtail fish tail c4031del cdel c 4031del del c.4031del Ser1344*, Ser1344 Ser Ser1344* , (Ser1344*) 49.27%, 4927 49.27% 49 27 (49.27%) 16 Conclusions Furthermore firstline first line participants literature 28.9 2 (28.9 71.1 7 (71.1 Ser134 (Ser1344* 492 49.27 (49.27% 28. (28. 71. (71. Ser13 (Ser1344 49.2 (49.27 (28 (71 Ser1 (Ser134 49. (49.2 (2 (7 (Ser13 (49. ( (Ser1 (49 (Ser (4

Resumen: El objetivo fue analizar la visión de los jueces federales brasileños sobre las implicaciones de la vacunación contra la COVID-19. Se realizó un estudio con jueces federales brasileños, quienes recibieron una encuesta elaborada con preguntas de opción múltiple sobre la vacunación contra la COVID-19, abordando temas como su obligatoriedad, aplicación de medidas coercitivas, reticencia a vacunarse, grupos prioritarios, acciones de Agência Nacional de Vigilancia Sanitaria (Anvisa), el papel del Poder Judicial y los pasaportes de inmunidad. Respondieron a la encuesta 254 de los 1.300 jueces federales que actúan en todos los estados. La mayoría de los encuestados tiene título de licenciatura o especialización (59,1%) y actúa como juez desde hace más de 10 años (63,8%). Gran parte de los jueces (87,7%) está de acuerdo con la obligatoriedad de la vacuna para adultos y niños y adolescentes (66,1%). Más del 75% de los jueces cree que todos los niveles de gobierno pueden imponer sanciones a quienes se nieguen a vacunarse. El 93% de los jueces confía en la vacunación, el 56,1% rechaza los movimientos antivacunas y el 75,2% cree que las acciones de Anvisa deben ser respetadas. Las acciones del Poder Judicial con relación a la pandemia de COVID-19 son aprobadas por el 62,6% de los jueces, y el 88,2% apoya los pasaportes de inmunidad. Existe un vínculo directo entre la vacunación obligatoria, la confianza en la vacuna y la adopción de pasaportes de inmunidad. La mayoría de los jueces federales está de acuerdo con la vacunación obligatoria para niños y adultos, apoya la aplicación de sanciones en caso de rechazo de la vacunación, desaprueba los movimientos antivacunas, está de acuerdo con las acciones de Anvisa y apoya la intervención del Poder Judicial con relación a la pandemia de COVID-19.

Resumo: O objetivo foi analisar a visão de juízes federais brasileiros sobre as implicações da vacinação contra a COVID-19. Foi realizado um estudo com juízes federais brasileiros, que receberam uma pesquisa elaborada com questões de múltipla escolha sobre a vacinação contra a COVID-19, abordando temas como sua obrigatoriedade, aplicação de medidas coercitivas, hesitação vacinal, grupos prioritários, ações da Agência Nacional de Vigilância Sanitária (Anvisa), o papel do Poder Judiciário e os passaportes de imunidade. Responderam à pesquisa 254 dos 1.300 juízes federais atuantes em todos os estados. A maioria dos entrevistados possui bacharelado ou especialização (59,1%) e atua como juiz há mais de 10 anos (63,8%). Grande parte dos juízes (87,7%) concorda com a obrigatoriedade da vacina para adultos e crianças e adolescentes (66,1%). Mais de 75% dos juízes acreditam que todos os níveis de governo podem impor sanções para aqueles que se recusam a ser vacinados. 93% dos juízes confiam na vacinação, 56,1% rejeitam movimentos antivacinação e 75,2% acreditam que as ações da Anvisa devem ser respeitadas. As ações do Judiciário referentes à pandemia da COVID-19 são aprovadas por 62,6% dos juízes e 88,2% apoiam passaportes de imunidade. Existe uma ligação direta entre a vacinação obrigatória, a confiança na vacina e a adoção de passaportes de imunidade. A maioria dos juízes federais concorda com a obrigatoriedade da vacina para crianças e adultos, apoia a aplicação de sanções no caso de recusa de vacinação, desaprova movimentos antivacinação, concorda com as ações da Anvisa e apoia a intervenção do Judiciário em relação à pandemia da COVID-19.

Abstract: The aim was to analyze the perception of Brazilian federal judges on the implications of COVID-19 vaccination. A study was carried out with Brazilian federal judges, who received a survey designed with multiple-choice questions on COVID-19 vaccination, covering topics such as its mandatory aspect, the application of coercive measures, hesitation to vaccinate, priority groups, the duties of Brazilian Health Regulatory Agency (Anvisa, acronym in Portuguese), the role of the Judiciary branch, and immunity passports. A total of 254 out of 1,300 federal judges from all states responded to the survey. Most respondents have a Bachelor’s degree or a specialization (59.1%) and have been judges for more than 10 years (63.8%). A great majority of the judges (87.7%) agree with vaccine mandates for adults and for children and adolescents (66.1%). Over 75% of judges believe that all levels of government can impose sanctions on those who refuse to get vaccinated. The judges trust vaccination 93% of the time, 56.1% reject anti-vaccination movements, and 75.2% believe that Anvisa duties should be respected. The Judiciary branch actions concerning the COVID-19 pandemic are approved by 62.6% of judges, and 88.2% support immunity passports. There is a direct connection among mandatory vaccination, trust in the vaccine, and the adoption of immunity passports. Most federal judges agree with vaccine mandates for children and adults, support the application of sanctions for vaccination refusal, disapprove of anti-vaccination movements, agree with Anvisa’s duties, and support judicial intervention in relation to the COVID-19 pandemic.

Abstract Associations between the WNT5A rs566926 variant and non-syndromic orofacial cleft (NSOC) have been reported in different populations. Objective This study aimed to investigate the role of the rs566926 single nucleotide polymorphism (SNP) in WNT5A and its interactions with SNPs in BMP4, FGFR1, GREM1, MMP2, and WNT3 in the occurrence of NSOC in a Brazilian population. Methodology A case-control genetic association study was carried out involving participants from four regions of Brazil, totaling 801 patients with non-syndromic cleft lip with or without cleft palate (NSCL±P), 273 patients with cleft palate only (NSCPO), and 881 health volunteers without any congenital condition (control). Applying TaqMan allelic discrimination assays, we evaluated WNT5A rs566926 in an ancestry-structured multiple logistic regression analysis, considering sex and genomic ancestry as covariates. Interactions between rs566926 and variants in genes involved in the WNT5A signaling pathway (BMP4, FGFR1, GREM1, MMP2, and WNT3) were also explored. Results WNT5A rs566926 was significantly associated with an increased risk of NSCL±P, particularly due to a strong association with non-syndromic cleft lip only (NSCLO), in which the C allele increased the risk by 32% (OR: 1.32, 95% CI: 1.04–1.67, p=0.01). According to the proportions of European and African genomic ancestry, the association of rs566926 reached significant levels only in patients with European ancestry. Multiple interactions were detected between WNT5A rs566926 and BMP4 rs2071047, GREM1 rs16969681 and rs16969862, and FGFR1 rs7829058. Conclusion The WNT5A rs566926 polymorphism was associated with NSCL±P, particularly in individuals with NSCLO and high European ancestry. Epistatic interactions involving WNT5A rs566926 and variants in BMP4, GREM1, and FGFR1 may contribute to the risk of NSCL±P in the Brazilian population. WNTA WNT rs rs56692 nonsyndromic non syndromic (NSOC populations SNP (SNP BMP FGFR GREM MMP2 MMP population casecontrol case control Brazil 80 NSCLP , NSCL P (NSCL±P) 27 NSCPO, NSCPO (NSCPO) 88 control. . (control) assays ancestrystructured structured analysis covariates (BMP4 explored NSCLO, (NSCLO) 32 OR (OR 132 1 1.32 95 CI 104167 04 67 1.04–1.67 p=0.01. p001 p p=0.01 0 01 p=0.01) rs2071047 rs1696968 rs16969862 rs7829058 rs5669 8 (NSCL±P 2 (NSCPO (control (BMP (NSCLO 3 13 1.3 9 10416 6 1.04–1.6 p00 p=0.0 rs207104 rs169696 rs1696986 rs782905 rs566 1. 1041 1.04–1. p0 p=0. rs20710 rs16969 rs169698 rs78290 rs56 104 1.04–1 p=0 rs2071 rs1696 rs7829 rs5 10 1.04– p= rs207 rs169 rs782 1.04 rs20 rs16 rs78 1.0 rs2 rs1 rs7

Aim This present study aims to compare the data from the Brazilian Unified Health System on the number of clinical consultations of Oral Medicine from the first 6 months (March-August 2020) of the COVID-19 pandemic in Brazil with the last 6 months (September-February 2020/2021) to update the data, verify the measures’ effectiveness to return clinical activities in the following months. Methods perform a literature review of recent articles that report the impact of the COVID-19 pandemic on Oral Medicine. Results There was an increase in the number of Oral Medicine clinical consultations in the second half of the pandemic throughout Brazil (+64.2%), representing over 9,235 appointments in this period. Conclusion measures for the return of health assistance and the practice of Telemedicine proved to be effective after the second period of the pandemic. Even so, strengthening security measures against the coronavirus is essential to ward off a new wave since the Omicron variant emerged in the country and, consequently, possible new lockdowns that might affect healthcare in Brazil. MarchAugust March August 2020 COVID19 COVID 19 COVID-1 SeptemberFebruary September February 2020/2021 20202021 2021 +64.2%, 642 +64.2% , 64 2 (+64.2%) 9235 9 235 9,23 so consequently 202 COVID1 1 COVID- 2020/202 2020202 +64.2 (+64.2% 923 23 9,2 20 2020/20 202020 +64. (+64.2 92 9, 2020/2 20202 +64 (+64. 2020/ +6 (+64 + (+6 (+ (

RESUMO Objetivo: Relatar o caso de uma jovem que apresentava um fenótipo grave de displasia mandibuloacral tipo A (MADA) caracterizado por alterações osteolíticas proeminentes e defeitos ectodérmicos, associados a uma rara mutação homozigótica missense no gene LMNA (c.1579C>T). Descrição do caso: Uma menina de seis anos foi avaliada durante hospitalização apresentando os seguintes sinais dismórficos: alopecia subtotal, fácies dismórfica com olhos proeminentes, micrognatia e retrognatia acentuada, nariz pequeno e adunco, dentes apinhados e lábios finos, lipodistrofia generalizada, ombros estreitos e inclinados, rigidez articular e reabsorção óssea nas falanges terminais. Ao exame dermatológico, observou-se pele atrófica, perda da elasticidade cutânea, hiperceratose, calcinose dérmica e manchas hiperpigmentadas e hipocrômicas. Exames radiológicos realizados mostraram ausência de côndilos mandibulares bilaterais, reabsorção da clavícula com massa óssea amorfa local confluindo com as escápulas, articulações do ombro com subluxação e displasia óssea severa, com displasia coxofemoral, osteopenia e calcificações subcutâneas. Comentários: MADA é uma doença autossômica recessiva rara causada por mutações no gene LMNA. Caracteriza-se por deformidades craniofaciais, anomalias esqueléticas, alterações cutâneas, lipodistrofia em determinadas regiões do corpo e envelhecimento precoce. MADA típica é causada pela mutação p.R527H no gene LMNA. No entanto, a análise molecular realizada com células epiteliais orais obtidas da paciente mostrou a mutação rara c.1579C>T, p. R527C no exon 9 do gene LMNA. Esta é a sexta família identificada com essa mutação descrita na literatura. Objetivo (MADA ectodérmicos c.1579C>T. c1579CT cCT c.1579C>T . c 1579C T C (c.1579C>T) dismórficos subtotal acentuada adunco finos generalizada inclinados terminais dermatológico observouse observou se atrófica cutânea hiperceratose hipocrômicas bilaterais escápulas severa coxofemoral subcutâneas Comentários Caracterizase Caracteriza craniofaciais esqueléticas cutâneas precoce pR527H pRH p R527H R H entanto RC literatura CT (c.1579C>T pR RH

ABSTRACT Objective: To report the case of a girl presenting a severe phenotype of mandibuloacral dysplasia type A (MADA) characterized by prominent osteolytic changes and ectodermal defects, associated with a rare homozygous LMNA missense mutation (c.1579C>T). Case description: A 6-year-old girl was evaluated during hospitalization exhibiting the following dysmorphic signs: subtotal alopecia, dysmorphic facies with prominent eyes, marked micrognathia and retrognathia, small beaked nose, teeth crowding and thin lips, generalized lipodystrophy, narrow and sloping shoulders, generalized joint stiffness and bone reabsorption in the terminal phalanges. In dermatological examination, atrophic skin, loss of cutaneous elasticity, hyperkeratosis, dermal calcinosis, and hyperpigmented and hypochromic patches were observed. Radiology exams performed showed bilateral absence of the mandibular condyles, clavicle resorption with local amorphous bone mass confluence with the scapulae, shoulder joints with subluxation and severe bone dysplasia, hip dysplasia, osteopenia and subcutaneous calcifications. Comments: MADA is a rare autosomal recessive disease caused by mutations in LMNA gene. It is characterized by craniofacial deformities, skeletal anomalies, skin alterations, lipodystrophy in certain regions of the body and premature ageing. Typical MADA is caused by the p.R527H mutation in the LMNA gene. However, molecular analysis performed from oral epithelial cells obtained from the patient showed the rare mutation c.1579C>T, p. R527C in the exon 9 of LMNA. This is the sixth family identified with this mutation described in the literature. Objective (MADA defects c.1579C>T. c1579CT cCT c.1579C>T . c 1579C T C (c.1579C>T) description 6yearold yearold 6 year old signs alopecia eyes retrognathia nose lips shoulders phalanges examination elasticity hyperkeratosis calcinosis observed condyles scapulae calcifications Comments gene deformities anomalies alterations ageing pR527H pRH p R527H R H However RC literature CT (c.1579C>T pR RH

Resumo: O objetivo foi analisar a visão de juízes federais brasileiros sobre as implicações da vacinação contra a COVID-19. Foi realizado um estudo com juízes federais brasileiros, que receberam uma pesquisa elaborada com questões de múltipla escolha sobre a vacinação contra a COVID-19, abordando temas como sua obrigatoriedade, aplicação de medidas coercitivas, hesitação vacinal, grupos prioritários, ações da Agência Nacional de Vigilância Sanitária (Anvisa), o papel do Poder Judiciário e os passaportes de imunidade. Responderam à pesquisa 254 dos 1.300 juízes federais atuantes em todos os estados. A maioria dos entrevistados possui bacharelado ou especialização (59,1%) e atua como juiz há mais de 10 anos (63,8%). Grande parte dos juízes (87,7%) concorda com a obrigatoriedade da vacina para adultos e crianças e adolescentes (66,1%). Mais de 75% dos juízes acreditam que todos os níveis de governo podem impor sanções para aqueles que se recusam a ser vacinados. 93% dos juízes confiam na vacinação, 56,1% rejeitam movimentos antivacinação e 75,2% acreditam que as ações da Anvisa devem ser respeitadas. As ações do Judiciário referentes à pandemia da COVID-19 são aprovadas por 62,6% dos juízes e 88,2% apoiam passaportes de imunidade. Existe uma ligação direta entre a vacinação obrigatória, a confiança na vacina e a adoção de passaportes de imunidade. A maioria dos juízes federais concorda com a obrigatoriedade da vacina para crianças e adultos, apoia a aplicação de sanções no caso de recusa de vacinação, desaprova movimentos antivacinação, concorda com as ações da Anvisa e apoia a intervenção do Judiciário em relação à pandemia da COVID-19. Resumo COVID19. COVID19 COVID 19. 19 COVID19, 19, coercitivas vacinal prioritários Anvisa, , (Anvisa) imunidade 25 1300 1 300 1.30 estados 59,1% 591 59 (59,1% 63,8%. 638 63,8% . 63 8 (63,8%) 87,7% 877 87 7 (87,7% 66,1%. 661 66,1% 66 (66,1%) 75 vacinados 93 561 56 56,1 752 2 75,2 respeitadas COVID-1 626 62 6 62,6 882 88 88,2 obrigatória COVID1 (Anvisa 130 30 1.3 59,1 5 (59,1 63,8 (63,8% 87,7 (87,7 66,1 (66,1% 9 56, 75, COVID- 62, 88, 13 3 1. 59, (59, 63, (63,8 87, (87, 66, (66,1 (59 (63, (87 (66, (5 (63 (8 (66 ( (6

Abstract: The aim was to analyze the perception of Brazilian federal judges on the implications of COVID-19 vaccination. A study was carried out with Brazilian federal judges, who received a survey designed with multiple-choice questions on COVID-19 vaccination, covering topics such as its mandatory aspect, the application of coercive measures, hesitation to vaccinate, priority groups, the duties of Brazilian Health Regulatory Agency (Anvisa, acronym in Portuguese), the role of the Judiciary branch, and immunity passports. A total of 254 out of 1,300 federal judges from all states responded to the survey. Most respondents have a Bachelor’s degree or a specialization (59.1%) and have been judges for more than 10 years (63.8%). A great majority of the judges (87.7%) agree with vaccine mandates for adults and for children and adolescents (66.1%). Over 75% of judges believe that all levels of government can impose sanctions on those who refuse to get vaccinated. The judges trust vaccination 93% of the time, 56.1% reject anti-vaccination movements, and 75.2% believe that Anvisa duties should be respected. The Judiciary branch actions concerning the COVID-19 pandemic are approved by 62.6% of judges, and 88.2% support immunity passports. There is a direct connection among mandatory vaccination, trust in the vaccine, and the adoption of immunity passports. Most federal judges agree with vaccine mandates for children and adults, support the application of sanctions for vaccination refusal, disapprove of anti-vaccination movements, agree with Anvisa’s duties, and support judicial intervention in relation to the COVID-19 pandemic. Abstract COVID19 COVID 19 COVID-1 multiplechoice multiple choice aspect measures vaccinate groups Anvisa, (Anvisa Portuguese, Portuguese , Portuguese) passports 25 1300 1 300 1,30 Bachelors Bachelor s 59.1% 591 59 (59.1% 63.8%. 638 63.8% . 63 8 (63.8%) 87.7% 877 87 7 (87.7% 66.1%. 661 66.1% 66 (66.1%) 75 vaccinated 93 time 561 56 56.1 antivaccination anti movements 752 2 75.2 respected 626 62 6 62.6 882 88 88.2 refusal Anvisas COVID1 COVID- 130 30 1,3 59.1 5 (59.1 63.8 (63.8% 87.7 (87.7 66.1 (66.1% 9 56. 75. 62. 88. 13 3 1, 59. (59. 63. (63.8 87. (87. 66. (66.1 (59 (63. (87 (66. (5 (63 (8 (66 ( (6

Resumen: El objetivo fue analizar la visión de los jueces federales brasileños sobre las implicaciones de la vacunación contra la COVID-19. Se realizó un estudio con jueces federales brasileños, quienes recibieron una encuesta elaborada con preguntas de opción múltiple sobre la vacunación contra la COVID-19, abordando temas como su obligatoriedad, aplicación de medidas coercitivas, reticencia a vacunarse, grupos prioritarios, acciones de Agência Nacional de Vigilancia Sanitaria (Anvisa), el papel del Poder Judicial y los pasaportes de inmunidad. Respondieron a la encuesta 254 de los 1.300 jueces federales que actúan en todos los estados. La mayoría de los encuestados tiene título de licenciatura o especialización (59,1%) y actúa como juez desde hace más de 10 años (63,8%). Gran parte de los jueces (87,7%) está de acuerdo con la obligatoriedad de la vacuna para adultos y niños y adolescentes (66,1%). Más del 75% de los jueces cree que todos los niveles de gobierno pueden imponer sanciones a quienes se nieguen a vacunarse. El 93% de los jueces confía en la vacunación, el 56,1% rechaza los movimientos antivacunas y el 75,2% cree que las acciones de Anvisa deben ser respetadas. Las acciones del Poder Judicial con relación a la pandemia de COVID-19 son aprobadas por el 62,6% de los jueces, y el 88,2% apoya los pasaportes de inmunidad. Existe un vínculo directo entre la vacunación obligatoria, la confianza en la vacuna y la adopción de pasaportes de inmunidad. La mayoría de los jueces federales está de acuerdo con la vacunación obligatoria para niños y adultos, apoya la aplicación de sanciones en caso de rechazo de la vacunación, desaprueba los movimientos antivacunas, está de acuerdo con las acciones de Anvisa y apoya la intervención del Poder Judicial con relación a la pandemia de COVID-19. Resumen COVID19. COVID19 COVID 19. 19 COVID19, 19, coercitivas vacunarse prioritarios Anvisa, , (Anvisa) inmunidad 25 1300 1 300 1.30 estados 59,1% 591 59 (59,1% 63,8%. 638 63,8% . 63 8 (63,8%) 87,7% 877 87 7 (87,7% 66,1%. 661 66,1% 66 (66,1%) 75 93 561 56 56,1 752 2 75,2 respetadas COVID-1 626 62 6 62,6 882 88 88,2 COVID1 (Anvisa 130 30 1.3 59,1 5 (59,1 63,8 (63,8% 87,7 (87,7 66,1 (66,1% 9 56, 75, COVID- 62, 88, 13 3 1. 59, (59, 63, (63,8 87, (87, 66, (66,1 (59 (63, (87 (66, (5 (63 (8 (66 ( (6

Resumo Introdução: A produção científica brasileira apresentou crescimento substancial e visibilidade internacional. Contudo, em geral, a participação das mulheres em atividades científicas ainda é limitada. Objetivo: Este estudo objetivou avaliar os indicadores de produtividade científica de mulheres bolsistas do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) na área de medicina. Método: Foi realizado estudo transversal com 541 (211 mulheres, 39%) pesquisadores cadastrados como bolsistas de produtividade em medicina do CNPq conforme lista disponibilizada em dezembro de 2022. Resultado: Houve predomínio de pesquisadores do sexo masculino (n = 330; 61%). Em ambos os grupos, masculino e feminino, a maioria dos investigadores encontra-se no nível 2, sendo 62,5% mulheres e 47,2% homens (p = 0,018). Todos os 211 pesquisadores foram distribuídos em 37 instituições diferentes e publicaram 34.969 artigos em revistas científicas, com média de 165,7 artigos por pesquisador. De 2018 a 2022, foram publicados 9.679 artigos. Ao longo de suas carreiras, os 211 pesquisadores orientaram 5.440 alunos de iniciação científica, 4.144 alunos de mestrado e 2.923 alunos de doutorado. Houve diferença significativa entre os níveis de bolsas quanto ao desenvolvimento de recursos humanos em iniciação científica (p = 0,040), mestrado (p = 0,027) e doutorado (p < 0,001). Conclusão: Ainda há menor participação de mulheres do que de homens entre os pesquisadores médicos do CNPq. Contudo, foi possível observar participação substancial das mulheres em todos os quesitos avaliados, incluindo a produção técnica e científica e a formação de recursos humanos. Introdução internacional Contudo geral limitada Objetivo (CNPq Método 54 (21 39% 39 2022 Resultado n 330 61%. 61 61% . 61%) grupos feminino encontrase encontra se 2 625 62 5 62,5 472 47 47,2 p 0,018. 0018 0,018 0 018 0,018) 21 3 34969 34 969 34.96 1657 165 7 165, pesquisador 201 9679 9 679 9.67 carreiras 5440 440 5.44 4144 4 144 4.14 2923 923 2.92 0,040, 0040 0,040 , 040 0,040) 0,027 0027 027 0,001. 0001 0,001 001 0,001) Conclusão avaliados (2 202 33 6 62, 47, 0,01 01 3496 96 34.9 16 20 967 67 9.6 544 44 5.4 414 14 4.1 292 92 2.9 004 0,04 04 0,02 002 02 000 0,00 00 ( 0,0 349 34. 1 9. 5. 41 4. 29 2. 0,

Abstract Introduction: Brazilian scientific production has shown substantial growth and achieved international visibility. However, in general, the participation of women in scientific activities remains limited. Objective: This study aimed to evaluate the indicators of scientific productivity of women fellows of the Council for Scientific and Technological Development (CNPq) in the field of Medicine. Method: This cross-sectional study was conducted on 541 (211 women, 39%) researchers registered as recipients of CNPq research productivity (PQ) scholarships in Medicine according to a list provided in December 2022. Results: There was a predominance of male researchers (n=330; 61%). In both the male and female groups, most researchers were at level 2, with 62.5% women and 47.2% men (p=0.018). All 211 female PQ scholars were distributed among 37 different institutions and published 34,969 papers in scientific journals, averaging 165.7 articles per researcher. In the last five years of the study period (from 2018 to 2022), 9,679 papers were published. Over their careers, the 211 researchers supervised 5,440 undergraduate research students, 4,144 master’s degree students, and 2,923 PhD candidates. There was a significant difference between the scholarship levels for the development of human resources in undergraduate research (p=0.040), master’s degree (p=0.027), and PhD. (p<0.001). Conclusion: There are still less women participating in CNPq medical research than men. However, we observed a substantial participation of women in all the assessed items, including technical and scientific production and the human resources training. Introduction visibility However general limited Objective (CNPq Method crosssectional cross sectional 54 (21 39% 39 (PQ 2022 Results n=330 n330 n 330 (n=330 61%. 61 61% . 61%) groups 2 625 62 5 62.5 472 47 47.2 p=0.018. p0018 p p=0.018 0 018 (p=0.018) 21 3 34969 34 969 34,96 journals 1657 165 7 165. researcher from 201 2022, , 2022) 9679 9 679 9,67 careers 5440 440 5,44 students 4144 4 144 4,14 masters master s 2923 923 2,92 candidates p=0.040, p0040 p=0.040 040 (p=0.040) p=0.027, p0027 p=0.027 027 (p=0.027) p<0.001. p0001 p<0.001 001 (p<0.001) Conclusion items training (2 202 n=33 n33 33 (n=33 6 62. 47. p001 p=0.01 01 (p=0.018 3496 96 34,9 16 20 967 67 9,6 544 44 5,4 414 14 4,1 292 92 2,9 p004 p=0.04 04 (p=0.040 p002 p=0.02 02 (p=0.027 p000 p<0.00 00 (p<0.001 ( n=3 n3 (n=3 p00 p=0.0 (p=0.01 349 34, 1 9, 5, 41 4, 29 (p=0.04 (p=0.02 p<0.0 (p<0.00 n= (n= p0 p=0. (p=0.0 p<0. (p<0.0 (n p=0 (p=0. p<0 (p<0. p= (p=0 p< (p<0 (p= (p< (p

Objective: To determine clinical outcomes and mortality risk factors related to mental disorders in a cohort of hospitalized patients with Covid-19 in Brazil. Methods: This retrospective cohort study used a Brazilian database called the Sistema de Vigilância Epidemiológica da Gripe (Influenza Epidemiological Surveillance System) to analyze patients aged ≥ 18 years who were hospitalized with Covid-19 between 2020 and 2022. The exposure of interest was mental disorders (anxiety, depression, schizophrenia, and bipolar disorder) identified through self-report. The primary outcome was in-hospital mortality. Covariates included demographic and clinical characteristics. Descriptive statistics, t-tests, chi-square tests, and binary logistic regression were used to analyze the data. Results: A cohort of 2,124,285 patients was included in the analysis, with 23,246 individuals (1.1%) self-reporting mental disorders, of which depression was the most prevalent (52.3%). The mortality rate of patients with mental disorders was 30.8%. Age, sex, region, dyspnea, low oxygen saturation, and comorbidities were associated with a higher mortality risk, as was schizophrenia (adjusted OR: 1.68; 95%CI 1.54-1.81). Conclusions: Individuals with schizophrenia had a greater likelihood of Covid-19-related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on Covid-19 mortality. Objective Covid19 Covid 19 Covid-1 Brazil Methods Influenza System 1 202 2022 anxiety, anxiety (anxiety disorder selfreport. selfreport self report. report self-report inhospital hospital characteristics statistics ttests, ttests t tests t-tests chisquare chi square data Results 2124285 2 124 285 2,124,28 analysis 23246 23 246 23,24 1.1% 11 (1.1% selfreporting reporting 52.3%. 523 52.3% . 52 3 (52.3%) 308 30 8 30.8% Age sex region dyspnea saturation adjusted OR 1.68 168 68 95CI CI 95 1.541.81. 154181 1.54 1.81 54 81 1.54-1.81) Conclusions Covid19related Covidrelated conditions Covid1 Covid- 20 212428 12 28 2,124,2 2324 24 23,2 1.1 (1.1 52.3 5 (52.3% 30.8 1.6 16 6 9 541 1.541.81 15418 154 1.5 181 1.8 1.54-1.81 21242 2,124, 232 23, 1. (1. 52. (52.3 30. 1.541.8 1541 15 1.54-1.8 2124 2,124 (1 (52. 1.541. 1.54-1. 212 2,12 ( (52 1.541 1.54-1 21 2,1 (5 1.54- 2,

Abstract This study evaluated the scientific contribution of Brazilian CNPq Research Productivity fellows (PQ) in Dentistry by areas of activity. This cross-sectional study included 217 active PQ who were grouped into six groups: (1) Biomaterials, Prosthodontics, and Restorative Dentistry; (2) Public Health and Epidemiology; (3) Oral Pathology, Stomatology, and Dental Radiology; (4) Pediatric Dentistry and Child Health; (5) Dental Clinic (Periodontics, Endodontics, Orthodontics, Oral Surgery, and Implantology), and (6) Basic Areas (Histology, Biochemistry, Molecular Biology, Physiology, Microbiology, Immunology, and Pharmacology). The PQ were predominantly male (n = 122; 56.2%), received level 2 scholarships (n = 121; 55.8%), and performed research in the Southeast region of Brazil (n = 160; 73.73%). Regarding supervision of undergraduate, master's, and PhD students, both during their entire careers and in the last 5 years, the highest average was observed for PQs in the field of Public Health and Epidemiology, the only area with higher average supervision of master's than that of undergraduate and PhD students. PQ in Public Health and Epidemiology had the highest average number of papers published over their career and in the last 5 years, followed by PQ in Pediatric Dentistry and Child Health and Dental Clinic. The high productivity of PQ is demonstrated by modern research performance indicators. Their scientific publications are indexed in bibliometric databases such as WoS, Scopus, and SciELO. Addtionally, highlighted among the PQ was the time since initiation of their scientific careers and master's and doctoral candidates trained. (PQ activity crosssectional cross sectional 21 groups 1 (1 Biomaterials Prosthodontics (2 3 (3 Pathology Stomatology Radiology 4 (4 (5 Periodontics, Periodontics (Periodontics Endodontics Orthodontics Surgery Implantology, Implantology , Implantology) 6 (6 Histology, Histology (Histology Biochemistry Biology Physiology Microbiology Immunology Pharmacology. Pharmacology . Pharmacology) n 122 56.2%, 562 56.2% 56 56.2%) 121 55.8%, 558 55.8% 55 8 55.8%) 160 73.73%. 7373 73.73% 73 73.73%) masters, masters master s, s students years indicators WoS Scopus SciELO Addtionally trained ( 12 56.2 55.8 16 737 73.73 7 56. 55. 73.7 73.

Resumo Introdução: O envelhecimento populacional está entre as transformações globais mais importantes. Na população idosa, há prevalência aumentada de condições crônicas que comprometem a autonomia relacionadas ao comprometimento cognitivo. Objetivo: Este estudo buscou estimar a prevalência de comprometimento cognitivo e os fatores associados em uma população de idosos. Método: Trata-se de pesquisa transversal analítica envolvendo idosos com 60 anos ou mais, cadastrados na Estratégia Saúde da Família de Montes Claros, Minas Gerais, Brasil. Para caracterização dos fatores sociodemográficos, hábitos de vida e condições de saúde, utilizou-se o instrumento Brazilian Older Americans Researches and Service Multidimensional Function Assessment Questionnaire; para avaliação cognitiva, o Mini Exame do Estado Mental, e os resultados, ajustados por escolaridade na análise de regressão logística binária, com apresentação de odds ratio (OR) e intervalos de confiança (IC) de 95%. Resultados: Dos 1.746 idosos avaliados, 11,5% apresentaram comprometimento cognitivo. Os fatores de risco associados foram idosos acima de 80 anos (OR=4,463; IC95% 3,160–6,304); analfabetos (OR=3,996; IC95% 2,716–5,791); sem companheiro (OR=1,989; IC95% 1,388–2,850); sedentários (OR=1,777; IC95% 1,208–2,613) e com histórico de Acidente Vascular Cerebral (OR=3,635; IC95% 2,213–5,971). Conclusões: Comprometimento cognitivo foi associado a variáveis passíveis de ações preventivas, como o acesso à escolarização e hábitos de vida saudáveis. Introdução importantes idosa Objetivo Método Tratase Trata se 6 Claros Gerais Brasil sociodemográficos saúde utilizouse utilizou Questionnaire cognitiva Mental resultados binária OR (OR IC (IC 95 95% Resultados 1746 1 746 1.74 avaliados 115 11 5 11,5 8 OR=4,463 OR4463 4 463 (OR=4,463 IC95 3,160–6,304 31606304 3 160 304 3,160–6,304) OR=3,996 OR3996 996 (OR=3,996 2,716–5,791 27165791 2 716 791 2,716–5,791) OR=1,989 OR1989 989 (OR=1,989 1,388–2,850 13882850 388 850 1,388–2,850) OR=1,777 OR1777 777 (OR=1,777 1,208–2,613 12082613 208 613 OR=3,635 OR3635 635 (OR=3,635 2,213–5,971. 22135971 2,213–5,971 . 213 971 2,213–5,971) Conclusões preventivas saudáveis 9 174 74 1.7 11, OR=4,46 OR446 46 (OR=4,46 IC9 3,160–6,30 3160630 16 30 OR=3,99 OR399 99 (OR=3,99 2,716–5,79 2716579 71 79 OR=1,98 OR198 98 (OR=1,98 1,388–2,85 1388285 38 85 OR=1,77 OR177 77 (OR=1,77 1,208–2,61 1208261 20 61 OR=3,63 OR363 63 (OR=3,63 2213597 2,213–5,97 21 97 17 7 1. OR=4,4 OR44 (OR=4,4 3,160–6,3 316063 OR=3,9 OR39 (OR=3,9 2,716–5,7 271657 OR=1,9 OR19 (OR=1,9 1,388–2,8 138828 OR=1,7 OR17 (OR=1,7 1,208–2,6 120826 OR=3,6 OR36 (OR=3,6 221359 2,213–5,9 OR=4, OR4 (OR=4, 3,160–6, 31606 OR=3, OR3 (OR=3, 2,716–5, 27165 OR=1, OR1 (OR=1, 1,388–2, 13882 1,208–2, 12082 22135 2,213–5, OR=4 (OR=4 3,160–6 3160 OR=3 (OR=3 2,716–5 2716 OR=1 (OR=1 1,388–2 1388 1,208–2 1208 2213 2,213–5 OR= (OR= 3,160– 316 2,716– 271 1,388– 138 1,208– 120 221 2,213– 3,160 31 2,716 27 1,388 13 1,208 12 22 2,213 3,16 2,71 1,38 1,20 2,21 3,1 2,7 1,3 1,2 2,2 3, 2, 1,

Abstract Background: Population aging is among the most important global transformations. In the elderly population, there is an increased prevalence of chronic conditions that compromise autonomy, related to cognitive impairment. Objective: This study sought to estimate the prevalence of cognitive impairment and associated factors in an elderly population. Method: This is a cross-sectional and analytical survey involving elderly people aged 60 years old or older, registered with the Family Health Strategy of Montes Claros, Minas Gerais, Brazil. To characterize sociodemographic factors, life habits and health conditions, the Brazilian Older Americans Researches and Service Multidimensional Function Assessment Questionnaire was used; for cognitive evaluation, the Mini Mental State Examination, and the results adjusted for education in the binary logistic regression analysis, with the presentation of odds ratios (OR) and 95% confidence intervals (CI). Results: Of the 1,746 aged individuals evaluated, 11.5% presented cognitive impairment. The associated risk factors were elderly over 80 years old (OR=4.463; 95%CI 3.160–6.304); illiterate (OR=3.996; 95%CI 2.716–5.791); without companion (OR=1.989; 95%CI 1.388–2.850); sedentary (OR=1.777; 95%CI 1.208–2.613), and with a history of stroke (OR=3.635; 95%CI 2.213–5.971). Conclusions: Cognitive commitment was associated with variables susceptible to preventive actions, such as access to schooling and healthy living habits. Background transformations population autonomy Objective Method crosssectional cross sectional 6 older Claros Gerais Brazil used evaluation Examination analysis OR (OR 95 CI. CI . (CI) Results 1746 1 746 1,74 evaluated 115 11 5 11.5 8 OR=4.463 OR4463 4 463 (OR=4.463 95CI 3.160–6.304 31606304 3 160 304 3.160–6.304) OR=3.996 OR3996 996 (OR=3.996 2.716–5.791 27165791 2 716 791 2.716–5.791) OR=1.989 OR1989 989 (OR=1.989 1.388–2.850 13882850 388 850 1.388–2.850) OR=1.777 OR1777 777 (OR=1.777 1.208–2.613, 12082613 1.208–2.613 , 208 613 1.208–2.613) OR=3.635 OR3635 635 (OR=3.635 2.213–5.971. 22135971 2.213–5.971 213 971 2.213–5.971) Conclusions actions 9 (CI 174 74 1,7 11. OR=4.46 OR446 46 (OR=4.46 3.160–6.30 3160630 16 30 OR=3.99 OR399 99 (OR=3.99 2.716–5.79 2716579 71 79 OR=1.98 OR198 98 (OR=1.98 1.388–2.85 1388285 38 85 OR=1.77 OR177 77 (OR=1.77 1208261 1.208–2.61 20 61 OR=3.63 OR363 63 (OR=3.63 2213597 2.213–5.97 21 97 17 7 1, OR=4.4 OR44 (OR=4.4 3.160–6.3 316063 OR=3.9 OR39 (OR=3.9 2.716–5.7 271657 OR=1.9 OR19 (OR=1.9 1.388–2.8 138828 OR=1.7 OR17 (OR=1.7 120826 1.208–2.6 OR=3.6 OR36 (OR=3.6 221359 2.213–5.9 OR=4. OR4 (OR=4. 3.160–6. 31606 OR=3. OR3 (OR=3. 2.716–5. 27165 OR=1. OR1 (OR=1. 1.388–2. 13882 12082 1.208–2. 22135 2.213–5. OR=4 (OR=4 3.160–6 3160 OR=3 (OR=3 2.716–5 2716 OR=1 (OR=1 1.388–2 1388 1208 1.208–2 2213 2.213–5 OR= (OR= 3.160– 316 2.716– 271 1.388– 138 120 1.208– 221 2.213– 3.160 31 2.716 27 1.388 13 12 1.208 22 2.213 3.16 2.71 1.38 1.20 2.21 3.1 2.7 1.3 1.2 2.2 3. 2. 1.

Resumen Objetivo: analizar la prevalencia de síntomas de trastornos mentales comunes (TMC) en profesionales sanitarios de la Atención Primaria de Salud de agosto a octubre de 2021. Métodos: estudio transversal realizado con profesionales de la salud de la macrorregión norte de Minas Gerais. El muestreo fue del tipo bola de nieve. La variable dependiente, TMC, se evaluó mediante el Self-Reporting Questionnaire (SRQ-20). En el análisis estadístico se utilizó la regresión de Poisson. Resultados: participaron 702 profesionales de salud. La prevalencia de TMC fue del 43,2%, mayor en quienes presentaban síntomas de trastornos mentales previos (RP = 2,42; IC95% 1,43;4,08) y actuales (RP = 1,54; IC95% 1,25;1,89); exceso de trabajo durante la pandemia (RP = 1,42; IC95% 1,16;1,73); síntomas previos de ansiedad (RP = 1,27; IC95% 1,01;1,61), depresión (RP = 1,27; IC95% 1,06;1,52) y otros trastornos mentales (RP = 1,20; IC95% 1,01;1,43). Conclusión: hubo una asociación entre los TMC y los síntomas previos y actuales de los trastornos mentales y la sobrecarga de trabajo durante la pandemia de COVID-19. Objetivo (TMC 2021 Métodos Gerais nieve dependiente SelfReporting Self Reporting SRQ20. SRQ20 SRQ 20 . (SRQ-20) Poisson Resultados 70 432 43 2 43,2% RP 2,42 242 42 IC95 IC 1,434,08 143408 1,43 4,08 1 4 08 1,43;4,08 1,54 154 54 1,251,89 125189 1,25 1,89 25 89 1,25;1,89) 1,42 142 1,161,73 116173 1,16 1,73 16 73 1,16;1,73) 1,27 127 27 1,011,61, 101161 1,01 1,61 , 01 61 1,01;1,61) 1,061,52 106152 1,06 1,52 06 52 1,06;1,52 1,20 120 1,011,43. 101143 1,01;1,43) Conclusión COVID19. COVID19 COVID 19. 19 COVID-19 202 SRQ2 (SRQ-20 7 43,2 2,4 24 IC9 434 1,434,0 14340 143 1,4 408 4,0 0 1,43;4,0 1,5 15 5 251 1,251,8 12518 125 1,2 189 1,8 8 1,25;1,89 14 161 1,161,7 11617 116 1,1 173 1,7 1,16;1,73 12 011 1,011,61 10116 101 1,0 1,6 6 1,01;1,61 061 1,061,5 10615 106 152 1,06;1,5 1,011,43 10114 1,01;1,43 COVID1 COVID-1 (SRQ-2 43, 2, 1,434, 1434 1, 40 4, 1,43;4, 1,251, 1251 18 1,25;1,8 1,161, 1161 11 17 1,16;1,7 1,011,6 1011 10 1,01;1,6 1,061, 1061 1,06;1, 1,011,4 1,01;1,4 COVID- (SRQ- 1,434 1,43;4 1,251 1,25;1, 1,161 1,16;1, 1,011, 1,01;1, 1,061 1,06;1 (SRQ 1,43; 1,25;1 1,16;1 1,011 1,01;1 1,06; 1,25; 1,16; 1,01;

Abstract Objective: to analyze the prevalence of symptoms of common mental disorders (CMDs) in Primary Health Care professionals between August-October/2021. Methods: this was a cross-sectional study conducted with health professionals in the Northern health macro-region of Minas Gerais state; snowball sampling was used; the dependent variable, CMDs, was evaluated using the Self-Reporting Questionnaire (SRQ-20); Poisson regression was used to perform the statistical analysis. Results: a total of 702 health professionals took part in the study; the prevalence of CDMs was 43.2%. It was higher in those with previous [prevalence ratios (PR) = 2.42; 95%CI 1.43;4.08] and current (PR = 1.54; 95%CI 1.25;1.89) symptoms of mental disorders, overwork during the pandemic (PR = 1.42; 95%CI 1.16;1.73), previous symptoms of anxiety (PR = 1.27; 95%CI 1.01;1.61), depression (PR = 1.27; 95%CI 1.06;1.52) and other mental disorders (PR = 1.20; 95%CI 1.01;1.43). Conclusion: there was an association between CDMs and presenting previous and current symptoms of mental disorders and work overload during the covid-19 pandemic. Objective CMDs (CMDs AugustOctober/2021. AugustOctober2021 AugustOctober August October/2021. October 2021 August-October/2021 Methods crosssectional cross sectional macroregion macro region state variable SelfReporting Self Reporting SRQ20 SRQ 20 (SRQ-20) analysis Results 70 432 43 2 43.2% PR 2.42 242 42 95CI CI 95 1.434.08 143408 1.43 4.08 1 4 08 1.43;4.08 1.54 154 54 1.251.89 125189 1.25 1.89 25 89 1.25;1.89 1.42 142 1.161.73, 116173 1.16 1.73 , 16 73 1.16;1.73) 1.27 127 27 1.011.61, 101161 1.01 1.61 01 61 1.01;1.61) 1.061.52 106152 1.06 1.52 06 52 1.06;1.52 1.20 120 1.011.43. 101143 . 1.01;1.43) Conclusion covid19 covid 19 covid-1 AugustOctober/2021 AugustOctober202 October2021 October/2021 202 August-October/202 SRQ2 (SRQ-20 7 43.2 2.4 24 9 434 1.434.0 14340 143 1.4 408 4.0 0 1.43;4.0 1.5 15 5 251 1.251.8 12518 125 1.2 189 1.8 8 1.25;1.8 14 161 1.161.73 11617 116 1.1 173 1.7 1.16;1.73 12 011 1.011.61 10116 101 1.0 1.6 6 1.01;1.61 061 1.061.5 10615 106 152 1.06;1.5 1.011.43 10114 1.01;1.43 covid1 covid- AugustOctober/202 AugustOctober20 October202 October/202 August-October/20 (SRQ-2 43. 2. 1.434. 1434 1. 40 4. 1.43;4. 1.251. 1251 18 1.25;1. 1.161.7 1161 11 17 1.16;1.7 1.011.6 1011 10 1.01;1.6 1.061. 1061 1.06;1. 1.011.4 1.01;1.4 AugustOctober/20 AugustOctober2 October20 October/20 August-October/2 (SRQ- 1.434 1.43;4 1.251 1.25;1 1.161. 1.16;1. 1.011. 1.01;1. 1.061 1.06;1 AugustOctober/2 October2 October/2 August-October/ (SRQ 1.43; 1.25; 1.161 1.16;1 1.011 1.01;1 1.06; AugustOctober/ October/ August-October 1.16; 1.01;

Resumo Objetivo: analisar a prevalência de sintomas de transtornos mentais comuns (TMCs) em profissionais de saúde da Atenção Primária à Saúde, no período agosto-outubro/2021. Métodos: estudo transversal com profissionais de saúde da macrorregião Norte de saúde de Minas Gerais; amostragem de tipo “bola de neve”; a variável dependente, TMCs, foi avaliada pelo Self-Reporting Questionnaire (SRQ-20); utilizou-se regressão de Poisson na análise estatística. Resultados: participaram 702 profissionais de saúde; a prevalência de TMCs foi de 43,2%, maior naqueles que apresentaram sintomas de transtornos mentais prévios [razão de prevalências (RP) = 2,42 ;IC95% 1,43;4,08] e atuais (RP = 1,54; IC95% 1,25;1,89), trabalho a mais durante a pandemia (RP = 1,42; IC95% 1,16;1,73), sintomas prévios de ansiedade (RP = 1,27; IC95% 1,01;1,61), depressão (RP = 1,27; IC95% 1,06;1,52) e outros transtornos mentais (RP = 1,20; IC95% 1,01;1,43). Conclusão: observou-se associação de TMCs com sintomas prévios e atuais de transtornos mentais e sobrecarga de trabalho, durante a pandemia da covid-19. Objetivo (TMCs Saúde agostooutubro/2021. agostooutubro2021 agostooutubro agosto outubro/2021. outubro 2021 agosto-outubro/2021 Métodos Gerais bola neve neve” dependente SelfReporting Self Reporting SRQ20 SRQ 20 (SRQ-20) utilizouse utilizou se estatística Resultados 70 432 43 2 43,2% razão RP 242 42 2,4 IC95 IC ;IC95 1,434,08 143408 1,43 4,08 1 4 08 1,43;4,08 1,54 154 54 1,251,89, 125189 1,25 1,89 , 25 89 1,25;1,89) 1,42 142 1,161,73, 116173 1,16 1,73 16 73 1,16;1,73) 1,27 127 27 1,011,61, 101161 1,01 1,61 01 61 1,01;1,61) 1,061,52 106152 1,06 1,52 06 52 1,06;1,52 1,20 120 1,011,43. 101143 . 1,01;1,43) Conclusão observouse observou covid19. covid19 covid 19. 19 covid-19 agostooutubro/2021 agostooutubro202 outubro2021 outubro/2021 202 agosto-outubro/202 SRQ2 (SRQ-20 7 43,2 24 2, IC9 ;IC9 434 1,434,0 14340 143 1,4 408 4,0 0 1,43;4,0 1,5 15 5 251 1,251,89 12518 125 1,2 189 1,8 8 1,25;1,89 14 161 1,161,73 11617 116 1,1 173 1,7 1,16;1,73 12 011 1,011,61 10116 101 1,0 1,6 6 1,01;1,61 061 1,061,5 10615 106 152 1,06;1,5 1,011,43 10114 1,01;1,43 covid1 covid-1 agostooutubro/202 agostooutubro20 outubro202 outubro/202 agosto-outubro/20 (SRQ-2 43, ;IC 1,434, 1434 1, 40 4, 1,43;4, 1,251,8 1251 18 1,25;1,8 1,161,7 1161 11 17 1,16;1,7 1,011,6 1011 10 1,01;1,6 1,061, 1061 1,06;1, 1,011,4 1,01;1,4 covid- agostooutubro/20 agostooutubro2 outubro20 outubro/20 agosto-outubro/2 (SRQ- 1,434 1,43;4 1,251, 1,25;1, 1,161, 1,16;1, 1,011, 1,01;1, 1,061 1,06;1 agostooutubro/2 outubro2 outubro/2 agosto-outubro/ (SRQ 1,43; 1,251 1,25;1 1,161 1,16;1 1,011 1,01;1 1,06; agostooutubro/ outubro/ agosto-outubro 1,25; 1,16; 1,01;

Abstract Hypertrichosis and dental anomalies may occur alone or in combination in the spectrum of many syndromes. To identify genetic entities characterized by hypertrichosis and dental anomalies, a search was performed in the Mendelian Inheritance in Man database with the terms “hypertrichosis” or “hirsutism” and “tooth” or “dental abnormalities.” Nondependent androgen metabolism disturbances were classified as hypertrichosis. Genetic entities with hypertrichosis and dental anomalies were included in the study. Additional searches were performed in the PubMed and Orphanet databases, when necessary, in order to include data from scientific articles. An integrative analysis of the genes associated with the identified syndromes was conducted using STRING to characterize biological processes, pathways, and interactive networks. The p-values were subjected to the false discovery rate for the correction of multiple tests. Thirty-nine syndromes were identified, and dental agenesis was the most frequent dental anomaly present in 41.02% (n = 16) of the syndromes. Causative genes were identified in 33 out of 39 genetic syndromes. Among them, 39 genes were identified, and 38 were analyzed by STRING, which showed 148 biological processes and three pathways that were statistically significant. The most significant biological processes were the disassembly of the nucleosome (GO:0006337, p = 1.09e-06), chromosomal organization (GO:0051276, p = 1.09e-06) and remodeling of the chromatin (GO: 0006338, p = 7.86e-06), and the pathways were hepatocellular carcinoma (hsa05225, p = 5.77e-05), thermogenesis (hsa04714, p = 0.00019), and cell cycle (hsa04110, p = 0.0433). Our results showed that the identification of hypertrichosis and dental anomalies may raise the suspicion of one of the thirty-nine syndromes with both phenotypes. “hypertrichosis hirsutism “hirsutism tooth “tooth abnormalities. abnormalities study databases necessary articles networks pvalues values tests Thirtynine Thirty nine 4102 41 02 41.02 n 16 3 them 14 GO0006337, GO0006337 GO 0006337, 0006337 (GO:0006337 1.09e06, 109e06 e 1.09e 06 , 1 09e GO0051276, GO0051276 0051276, 0051276 (GO:0051276 1.09e06 1.09e-06 (GO 0006338 7.86e06, 786e06 7.86e 7 86e 7.86e-06) hsa05225, hsa05225 hsa (hsa05225 5.77e05, 577e05 5.77e 05 5 77e 5.77e-05) hsa04714, hsa04714 (hsa04714 0.00019, 000019 0.00019 0 00019 0.00019) hsa04110, hsa04110 (hsa04110 0.0433. 00433 0.0433 . 0433 0.0433) thirtynine thirty phenotypes 410 4 41.0 GO000633 000633 (GO:000633 09e06 109e0 109e GO005127 005127 (GO:005127 1.09e0 1.09e-0 86e06 7.86e06 786e0 786e 7.86e-06 hsa0522 (hsa0522 77e05 5.77e05 577e0 577e 5.77e-05 hsa0471 (hsa0471 00001 0.0001 0001 hsa0411 (hsa0411 0043 0.043 043 41. GO00063 00063 (GO:00063 09e0 GO00512 00512 (GO:00512 1.09e- 86e0 7.86e0 7.86e-0 hsa052 (hsa052 77e0 5.77e0 5.77e-0 hsa047 (hsa047 0000 0.000 000 hsa041 (hsa041 004 0.04 04 GO0006 0006 (GO:0006 GO0051 0051 (GO:0051 7.86e- hsa05 (hsa05 5.77e- hsa04 (hsa04 0.00 00 0.0 GO000 (GO:000 GO005 005 (GO:005 hsa0 (hsa0 0. GO00 (GO:00 (hsa GO0 (GO:0

Abstract Objective The aim of this case-control study was to investigate environmental factors, such as caffeine, folic acid, nutritional iron supplementation, multivitamin complexes, alcohol, and tobacco (second-hand smoking), which have been described as risk factors for the development of oral clefts. Methods This case-control study employed convenience sampling and included 409 mothers: 132 with children with oral clefts (cases) and 277 with children without oral clefts (controls). The age range of the children in both groups was 0 to 2 years. A questionnaire was administered to each mother to inquire about their habits and food consumption during the first trimester of pregnancy. Results Folic acid supplementation was observed in 116 (87.8%) of the case group (p< 0.001) and 271 (97.8%) of the control group. Regarding the use of ferrous sulfate, 114 (86.3%) of the case group and 271 (97.8%) of the control group reported using it. In the case group, 84 (63.6%) mothers reported being exposed to second-hand smoke, and 5 (3.7%) reported alcohol consumption (p= 0.797). In terms of caffeine consumption, 127 mothers (95.4%) in the case group consumed it (p= 0.13), while 247 (88.8%) reported consumption in the control group. Conclusions The results suggest a direct relationship between secondhand smoke, alcohol consumption, and the lack of maternal supplementation with oral clefts. casecontrol complexes second hand smoking, smoking , smoking) 40 13 cases (cases 27 controls. controls . (controls) years pregnancy 11 87.8% 878 87 8 (87.8% p< p (p 0.001 0001 001 97.8% 978 97 (97.8% sulfate 86.3% 863 86 3 (86.3% 63.6% 636 63 6 (63.6% smoke 3.7% 37 7 (3.7% p= 0.797. 0797 0.797 797 0.797) 12 95.4% 954 95 4 (95.4% 0.13, 013 0.13 0.13) 24 88.8% 888 88 (88.8% 1 (controls 87.8 (87.8 0.00 000 00 97.8 9 (97.8 86.3 (86.3 63.6 (63.6 3.7 (3.7 079 0.79 79 95.4 (95.4 01 0.1 88.8 (88.8 87. (87. 0.0 97. (97. 86. (86. 63. (63. 3. (3. 07 0.7 95. (95. 0. 88. (88. (87 (97 (86 (63 (3 (95 (88 (8 (9 (6 (