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ABSTRACT Background: Trachoma is the leading infectious cause of blindness worldwide. It is a neglected tropical disease caused by Chlamydia trachomatis. The objective of this study was to analyze the trachoma-associated morbidity and mortality in Brazil from 2000 to 2022. This ecological time-series study was based on secondary data on trachoma obtained from hospital admissions (trachoma as the primary or secondary cause) and death certificates (trachoma as the underlying or associated cause). Methods: We calculated the sex- and age-standardized rates of hospital admissions and trachoma-specific mortality according to sociodemographic variables and analyzed the spatial distribution. Results: We identified 141/263,292,807 hospital admissions (primary cause: 83.0%) and 126/27,596,830 death certificates (associated cause: 91.3%) related to trachoma. Trachoma-related sequelae were reported in 8.5% of hospital admissions and 6.3% of death certificates. Trachoma was more common in males (hospital admissions and death certificates), people aged ≥70 years (hospital admissions and death certificates), those with brown skin (hospital admissions and death certificates), and those living in the North (hospital admissions) and Northeast (death certificates) regions of Brazil. Conclusions: Despite the relatively low rates of trachoma morbidity in Brazil, the associated mortality rates are of concern. The heterogeneous patterns of occurrence in the country in terms of population and territory reinforce the need to evaluate and monitor the available data, despite the low prevalence, in order to achieve and maintain the elimination targets in Brazil in the future. Background worldwide trachomatis trachomaassociated 200 2022 timeseries time series cause. . Methods sex agestandardized age standardized trachomaspecific specific distribution Results 141263292807 141 263 292 807 141/263,292,80 83.0% 830 83 0 12627596830 126 27 596 126/27,596,83 91.3% 913 91 3 Trachomarelated 85 8 5 8.5 63 6 6.3 certificates, , 70 ≥7 Conclusions concern prevalence future 20 202 14126329280 14 26 29 80 141/263,292,8 83.0 1262759683 12 2 59 126/27,596,8 91.3 9 8. 6. 7 ≥ 1412632928 1 141/263,292, 83. 126275968 126/27,596, 91. 141263292 141/263,292 12627596 126/27,596 14126329 141/263,29 1262759 126/27,59 1412632 141/263,2 126275 126/27,5 141263 141/263, 12627 126/27, 14126 141/263 1262 126/27 1412 141/26 126/2 141/2 126/ 141/