Abstract: University sports culture is an important component of the national cultural system. It is the crystallization of material and spiritual civilization in university sports, as well as the precipitation of sports culture and sports philosophy. However, in the new era, university sports culture presents problems, such as valuing intelligence over physical fitness, lacking in sports culture concepts, and separating spirit and material. In university education, more attention is often paid to academic and intellectual development, while sports and physical exercise are lightly regarded. In fact, university sports culture often focuses only on physical education and sports events, while ignoring the development of other aspects, resulting in an imbalance in the whole sports culture system. The insufficient investment of the school in sports facilities and equipment leads to a lack of necessary material support for students to engage in physical exercise. At the same time, the students’ understanding and pursuit of sports often remain on the surface, lacking in the pursuit of the spirit of the deep-seated. In review of university sports culture, dialectical materialism can be used to analyze the connection among the social background, development trend and mutual influence of sports culture. The perspective of social constructivism can also be used to explore the social construction process of sports culture, all participants’ roles and interactions, and the significance and influence of sports culture in society. Therefore, in order to better solve the problems existing in university sports culture, promote the rapid development of university sports culture in the new era, enhance the confidence of campus sports culture and build a strong sports culture, this article used dialectical materialism method to analyze the current situation of university sports. It explained the relationship between philosophy and sports culture from a philosophical perspective, as well as the current problems in sports culture. Finally, it used the method of social constructivism to explain it from different perspectives. Finally, through the social constructivism method, it examined the university sports culture in the new era and, dialectically, analyzed the forms, functions, reconstruction paths and future thinking of university sports culture. Research has found that the sports culture of universities, in the new era, plays an important role in cultural, educational, and political aspects. The reconstruction and future development of university sports culture, in the new era, need to combine Eastern and Western cultures, inherit excellent traditional culture and achieve innovative development of sports culture. Abstract system However fitness concepts regarded fact events aspects time surface deepseated. deepseated deep seated. seated deep-seated background participants interactions society Therefore Finally perspectives dialectically forms functions universities educational cultures

Resumen: La cultura deportiva universitaria es un componente importante del sistema cultural nacional. Es la cristalización de la civilización material y espiritual en el deporte universitario, así como la precipitación de la cultura deportiva y la filosofía del deporte. Sin embargo, en la nueva era, la cultura deportiva universitaria presenta problemas como valorar más la inteligencia que la forma física, carecer de conceptos de cultura deportiva y separar el espíritu de lo material. En la educación universitaria, generalmente se presta más atención al desarrollo académico e intelectual, mientras que no tanto al deporte y ejercicio físico. De hecho, la cultura deportiva universitaria a menudo se centra sólo en la educación física y los eventos deportivos, ignorando el desarrollo de otros aspectos, lo que da lugar a un desequilibrio en todo el sistema de cultura deportiva; la insuficiente inversión de la escuela en instalaciones y equipos deportivos conduce a una falta de apoyo material necesario para que los estudiantes lleven actividades de ejercicio físico. Al mismo tiempo, la comprensión y la búsqueda del deporte por parte de los estudiantes se quedan a menudo en la superficie, careciendo de la búsqueda del espíritu de lo profundo. En la revisión de la cultura deportiva universitaria, se puede utilizar el materialismo dialéctico para analizar la conexión entre el trasfondo social, la tendencia de desarrollo y la influencia mutua de la cultura deportiva; también se puede utilizar la perspectiva del constructivismo social para explorar el proceso de construcción social de la cultura deportiva, los papeles y las interacciones de todos los participantes, y el significado y la influencia de la cultura deportiva en la sociedad. Por consiguiente, para resolver mejor los problemas existentes en la cultura deportiva universitaria, promover el rápido desarrollo de la cultura deportiva universitaria en la nueva era, aumentar la confianza de la cultura deportiva universitaria y construir una cultura deportiva fuerte, este artículo utilizó el método del materialismo dialéctico para analizar la situación actual del deporte universitario. Explica la relación entre la filosofía y la cultura deportiva desde una perspectiva filosófica, así como los problemas actuales de la cultura deportiva. Utilizó el método del constructivismo social para explicarlo desde diferentes perspectivas. Por último, a través del método del constructivismo social, examinó la cultura deportiva universitaria en la nueva era y analizó dialécticamente las formas, funciones, vías de reconstrucción y pensamiento futuro de la cultura deportiva universitaria. La investigación ha constatado que la cultura deportiva de las universidades en la nueva era desempeña un papel importante en los aspectos cultural, educativo y político. La reconstrucción y el desarrollo futuro de la cultura deportiva universitaria en la nueva era necesitan combinar las culturas oriental y occidental, heredar la excelente cultura tradicional y lograr un desarrollo innovador de la cultura deportiva. Resumen nacional universitario embargo intelectual físico hecho tiempo superficie profundo participantes sociedad consiguiente fuerte filosófica perspectivas último formas funciones político occidental

OBJECTIVES: This study was conducted to investigate the risk factors for pulmonary abscess-related empyema by investigating the clinical characteristics and chest computed tomography imaging features of patients with pulmonary abscesses. METHODS: We retrospectively analyzed the chest computed tomography findings and clinical features of 101 cases of pulmonary abscess, including 25 cases with empyema (the experimental group) and 76 cases with no empyema (the control group). The potential risk factors for pulmonary abscess-related empyema were compared between the groups by using univariate and multivariate logistic regression analyses. RESULTS: The incidence of pulmonary abscess-related empyema was 24.8% (25/101). Univariate analysis showed that male gender, diabetes, pleuritic symptoms, white blood cells >10×109/L, albumin level <25 g/L, and positive sputum cultures were potential clinical-related risk factors and that an abscess >5 cm in diameter and transpulmonary fissure abscesses were potential computed tomography imaging-related risk factors for pulmonary abscess-related empyema. Multivariate logistic regression analysis showed that transpulmonary fissure abscesses (odds ratio=9.102, p=0.003), diabetes (odds ratio=9.066, p=0.003), an abscess >5 cm in diameter (odds ratio=8.998, p=0.002), and pleuritic symptoms (odds ratio=5.395, p=0.015) were independent risk factors for pulmonary abscess-related empyema. CONCLUSIONS: Transpulmonary fissure abscesses, diabetes, giant pulmonary abscesses, and pleuritic symptoms increased the risk of empyema among patients with pulmonary abscesses.

Abstract Purpose: To investigate the apoptotic mechanisms in rabbits with blast-induced acute lung injury (ALI). Methods: A total of 40 rabbits were randomly divided into a blank control group (A, n=10) and an experimental group (EXP, n=30). Explosion-induced chest-ALI models were prepared and sampled at different time points (4, 12, and 24h after modeling, T1-T3) to test the lung dry weight/wet weight ratio (W/D) and arterial oxygen pressure (PaO2), apoptosis of lung tissue by the TUNEL assay, and Caspase-3, Bax, and Bcl-2 levels by immunohistochemical analysis. Furthermore, lung tissue was sampled to observe pathological morphology by microscopy. Results: Under a light microscope, Group EXP exhibited obvious edema in the pulmonary interstitial substance and alveoli, a large number of red blood cells, inflammatory cells, and serous exudation in the alveolar cavity, as well as thickening of the pulmonary interstitial fluid. Compared to Group A, the W/D ratio was significantly increased in Group EXP (P<0.01), while PaO2 was significantly reduced (P<0.01). The apoptosis index was significantly increased (P<0.01), and caspase-3 and Bax/Bcl-2 levels were increased (P<0.01). Conclusion: Apoptosis plays an important role in the occurrence and development of acute lung injury in rabbits by participating in lung injury and promoting the progression of ALI.

ABSTRACT Background: primary biliary cholangitis (PBC) patients with a suboptimal response to ursodeoxycholic acid (UDCA) have a significantly worse survival rate. Fenofibrate has been shown to improve the short-term biochemical response in this group of patients. However, there is limited data available on the safety and efficacy of its long-term use, especially in patients with cirrhosis. Methods: in this retrospective cohort study, fenofibrate was given to PBC patients with a suboptimal response to at least 12 months of UDCA (13-15 mg/kg/d) therapy. Biochemistry data, GLOBE score and UK-PBC risk score at baseline and at different time points of treatment were compared. The safety profiles were also compared between cirrhotic and non-cirrhotic patient groups. Results: fenofibrate (200 mg/day) was given to 39 PBC patients with a suboptimal response to UDCA (15 cirrhotic and 24 non-cirrhotic patients). In the 26 patients who completed more than one year of combination therapy, the alkaline phosphatase (ALP) levels were 215 (185, 326) U/l, 122 (110, 202) U/l, 128 (106, 194) U/l, 124 (100, 181) U/l and 120 (82, 168) U/l, at baseline, three months, six months, 12 months and 24 months, respectively. All p values were < 0.01 when compared to baseline values. After two years of combination therapy, the UK-PBC risk score and GLOBE score did not significantly improve. The overall rates of adverse events were not significantly different between the cirrhotic and non-cirrhotic group. The elevation of liver enzymes was the most frequent side effect (n = 7), leading to a discontinuation in four patients. Furthermore, after two years of combination therapy, the serum creatinine levels and estimated glomerular filtration rates (eGFR) were significantly worse in both groups. Conclusion: fenofibrate add-on therapy could improve ALP and -GT levels in both non-cirrhotic and cirrhotic PBC patients with a suboptimal response to UDCA. However, patients need to be monitored carefully for a potential liver injury and nephrotoxicity.

Abstract To study the influence of a foundation structure on the ground, the finite layer method of composite ground is derived based on the finite layer method (FLM) theory of the semi-analytic numerical method and the force method principle of elastic material, which is used to analyze a layered ground including multiple internal constraint planes. By simplifying a pile body as a solid constraint composed of four side plane constraints, the composite ground FLM is applied to solve the displacement and stress field of the ground. The change of the ground displacement and stress caused by the addition of a single pile constraint are then discussed, and the influence rules of a pile position on the ground displacement are also determined. Finally, the necessity, rationality and validity of the composite ground FLM are demonstrated by the model test examples of a single pile and pile raft foundation.