Abstract Objective: Studies focusing on bone and joint infections (BJIs) in young infants are rare. Some cases of BJI are accompanied by sepsis. This study aimed to identify the clinical and bacteriological features of sepsis in neonates and young infants with BJIs. Methods: Neonates and infants younger than 3 months diagnosed with BJI in the present institution from 2014 to 2021 were retrospectively reviewed. Patient characteristics, clinical data, and outcomes were documented and compared between those with and without sepsis. Results: Twenty-five patients with a mean age of 34.8 days were included. Nine BJI cases had concomitant sepsis (group A), and 16 had BJI without sepsis (group B). Within group A, staphylococcus aureus was the major pathogenic germ (5 cases, of which 4 were of the methicillin-resistant staphylococcus aureus (MRSA) type). There was no statistical difference in male-to-female ratio, age, history of hospitalization, anemia, birth asphyxia, peripheral leukocyte counts, C-reactive protein on admission, and sequelae between groups. Univariate analyses indicated a significant difference in the incidence of septic arthritis (SA) combined with osteomyelitis (OM) (88.9% vs 37.5%), congenital deformities (44.4% vs 0%), and mean duration of symptoms (2.83 days vs 9.21 days) in comparisons between groups A and B. Conclusion: Staphylococcus aureus is the main pathogenic bacteria in BJI cases complicated with sepsis in neonates and young infants. Among infants younger than 3 months diagnosed with BJI, those with concurrent SA and OM, MRSA infection, or congenital deformities are more likely to develop sepsis. Objective BJIs (BJIs rare Methods 201 202 reviewed characteristics data Results Twentyfive Twenty five 348 34 8 34. included , A) 1 B . B) 5 ( methicillinresistant methicillin resistant (MRSA type. type type) maletofemale male female ratio hospitalization anemia asphyxia counts Creactive C reactive admission (SA OM (OM 88.9% 889 88 9 (88.9 37.5%, 375 37.5% 37 37.5%) 44.4% 444 44 (44.4 0%, 0 0% 0%) 2.83 283 2 83 (2.8 921 21 9.2 Conclusion infection 20 88.9 (88. 37.5 44.4 (44. 2.8 28 (2. 92 9. 88. (88 37. 44. (44 2. (2 (8 (4

RESUMO No setor aeronáutico, ligas de alumínio 2024 são amplamente empregadas devido à excelente resistência mecânica e baixa massa específica. No entanto, essas ligas são propensas à corrosão localizada em meios corrosivos específicos, sendo necessários métodos de tratamento para protegê-las. Inibidores a base de cromo hexavalente são eficientes, mas têm seu uso restrito devido aos riscos à saúde humana e impactos ambientais associados. Nesse sentido, filmes de polímeros condutores têm sido investigados para substituir compostos tóxicos. Neste estudo, investigou-se o desempenho de bicamadas de polipirrol na proteção da liga de alumínio 2024 contra corrosão. Os resultados dos testes de polarização potenciodinâmica, realizados em solução salina, mostraram um deslocamento dos valores de potencial de corrosão para a região mais positiva quando as superfícies de alumínio foram revestidas com o filme de polipirrol, indicando proteção anódica. Além disso, as curvas de Tafel indicaram que as densidades de corrente anódicas foram inferiores para a bicamada de polipirrol. Adicionalmente, a morfologia das superfícies analisada por Microscopia Eletrônica de Varredura demonstrou que as bicamadas foram compactas e homogêneas, permanecendo intactas mesmo após três dias de imersão em solução de cloreto, sugerindo que a bicamada de polipirrol pode proteger a superfície metálica contra corrosão. aeronáutico 202 específica entanto específicos protegêlas. protegêlas protegê las. las protegê-las eficientes associados sentido tóxicos estudo investigouse investigou se potenciodinâmica salina anódica disso Adicionalmente homogêneas cloreto 20 2

ABSTRACT In the aeronautical industry, 2024 aluminum alloys are widely used due to their excellent mechanical resistance and low specific mass. However, pitting formation is usual for these metal surfaces in certain corrosive environments, requiring treatment methods to protect them. Polypyrrole is a conductive polymer that has been studied for the protection of oxidizable metals against corrosion, as a viable alternative to toxic compounds. In this context, this study aims to investigate the performance of polypyrrole bilayers, electrodeposited in aqueous medium to protect 2024 aluminum alloy against corrosion. Potentiodynamic polarization curves, in corrosive chloride medium, indicated that the corrosion potential values were shifted towards the more positive values for the aluminum surfaces coated with polypyrrole films in relation to the surface of the metal just polished, indicating anodic protection. Furthermore, the Tafel curves indicated that the anodic current densities were lower for the polypyrrole bilayer electrodeposited in phosphoric acid and dodecylbenzenesulfonic acid, respectively. The morphology of the surfaces was investigated by Scanning Electron Microscopy and indicated that the bilayers were compact and homogeneous and that they were not damaged even after three days of immersion in chloride medium, indicating that the polymeric film can protect the metal against corrosion. industry 202 mass However environments them compounds context polished Furthermore respectively 20 2

Abstract Objectives To investigate the changes in the coagulation function and hemodynamic parameters in patients with Hemorrhagic Traumatic Shock (HTS) after restrictive fluid resuscitation. Methods A total of 139 patients with HTS admitted to our hospital were enrolled, among which 69 HTS patients were divided into the control group and the remaining 70 HTS patients as the observation group. Patients in the control group underwent regular fluid resuscitation, while those in the observation group underwent restrictive fluid resuscitation. Results During treatment, 70 patients in the observation group had a lower bleeding amount, infusion amount, and blood transfusion volume than those in the control group (p < 0.05). After treatment, patients in the observation group had better hemodynamic parameters and blood coagulation than those in the control group (p < 0.05), and the incidence rate in the observation group was only 12.9%, which was significantly lower than 60.87% in the control group, while the cure rate in the observation group was 100%, which was significantly higher than that in the control group (p < 0.05). Conclusions Restrictive fluid resuscitation could remarkably increase the cure rate and reduce the bleeding amount during HTS treatment, thereby benefiting the recovery of the patient's blood coagulation. (HTS 13 enrolled 6 7 treatment p 0.05. 005 0.05 . 0 05 0.05) 0.05, , 129 12 9 12.9% 6087 60 87 60.87 100 100% patient s 1 00 0.0 12.9 608 8 60.8 10 0. 12. 60.

RESUMO Objetivo: O futebol é o esporte preferido pelos estudantes universitários masculinos entre muitos esportes na China. Métodos: De acordo com a virilidade e as características competitivas dos estudantes universitários masculinos, um curso eletivo de futebol pode exercitar seus corpos e melhorar sua qualidade física. Embora os cursos eletivos afetem positivamente a saúde física dos estudantes universitários, diferentes projetos têm funções diferentes devido a seus outros conteúdos didáticos, formas de ensino, material didático, e métodos de ensino. Resultados: a implementação dos padrões nacionais da China para o físico dos estudantes universitários apresenta novas exigências para o nível de aptidão física dos estudantes universitários masculinos. No entanto, a pesquisa mostra que o nível geral de aptidão física dos estudantes universitários chineses está diminuindo, e a intensidade de exercício da maioria dos estudantes não pode atender às exigências. Conclusões: Para estudar a influência do esporte sobre o físico e a personalidade dos estudantes de acordo com o Student Physique and Health Standard, este documento estuda e analisa o impacto dos cursos eletivos de futebol universitário no corpo e na personalidade dos estudantes universitários e discute suas estratégias de treinamento. Nível de evidência II; Estudos terapêuticos – investigação de resultados de tratamento.

ABSTRACT Objective: Soccer is a favored sport for male college students among many sports in China. Methods: According to male college students’ virility and competitive characteristics, an elective soccer course can exercise their bodies and improve their physical quality. Although elective courses positively affect college students’ physical health, different projects have different functions due to their other teaching content, teaching forms, teaching material, and teaching methods. Results: the implementation of China’s national standards for college students’ physique presents new requirements for the fitness level of male college students. However, the research shows that the overall fitness level of Chinese college students is decreasing, and the exercise intensity of most students cannot meet the requirements. Conclusions: To study the influence of sports on students’ physique and personality according to the Student Physique and Health Standard, this paper studies and analyzes the impact of college soccer elective courses on college students’ bodies and personalities and discusses their training strategies. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMEN Objetivo: El fútbol es uno de los deportes favoritos de los estudiantes universitarios masculinos entre los muchos deportes que se practican en China. Métodos: De acuerdo con la virilidad y las características competitivas de los estudiantes universitarios masculinos, un curso de fútbol optativo puede ejercitar su cuerpo y mejorar su calidad física. Aunque los cursos optativos afectan positivamente a la salud física de los estudiantes universitarios, los distintos proyectos tienen funciones diferentes debido a otros contenidos didácticos, formas de enseñanza, material didáctico y métodos de enseñanza. Resultados: la aplicación de las normas nacionales chinas para el físico de los estudiantes universitarios presenta nuevos requisitos para el nivel de condición física de los estudiantes universitarios varones. Sin embargo, la investigación muestra que el nivel general de forma física de los estudiantes universitarios chinos está disminuyendo, y la intensidad del ejercicio de la mayoría de los estudiantes no puede cumplir con los requisitos. Conclusiones: Con el fin de estudiar la influencia del deporte en el físico y en la personalidad de los estudiantes de acuerdo con el Student Physique and Health Standard, este artículo estudia y analiza el impacto de los cursos optativos de fútbol universitario en el cuerpo y la personalidad de los estudiantes universitarios y discute sus estrategias de entrenamiento. Nivel de evidencia II; Estudios terapéuticos – investigación de resultados de tratamiento.

Abstract Coronary heart disease (CHD) is one of the main diseases causing morbidity and mortality globally, with oxidative damage and lipid peroxidation associated with oxidative stress and atherosclerosis. Cinnamomum migao is a Miao ethnomedicine that has been shown to provide relief from CHD symptoms. A gas chromatograph-mass spectrometer (GC-MS) was used to determine the chemical components of ten batches of migao fatty oil (MFO), yielding a total of 35 chemical constituents. The antioxidant activity of MFO in vitro was assessed using the DPPH· and ABTS·+ assay methods, and both indicated good antioxidant activity. The network pharmacology predicted the active constituents of MFO and their therapeutic influence on the mechanism of oxidative damage-induced coronary heart disease (OD-CHD). Six compounds were discovered in MFO, including tau-cadinol acetate and dodecanoic acid, which may play a role in OD-CHD by acting on lipids and atherosclerosis, the PI3K-Akt signalling pathway, and other pathways. In conclusion, our study lays the foundation for investigating the use of MFO in the treatment of OD-CHD.

OBJECTIVES: Patients with Type I neurofibromatosis scoliosis with intra-canal rib head protrusion are extremely rare. Current knowledge regarding the diagnosis and treatment for this situation are insufficient. The purpose of this study is to share our experience in the diagnosis and surgical treatments for such unique deformities. METHODS: Six patients with Type I neurofibromatosis scoliosis with rib head dislocation into the spinal canal were diagnosed at our institution. Posterior instrumentation and spinal fusion without intra-canal rib head resection via a posterior-only approach was performed for deformity correction and rib head extraction. The efficacy and outcomes of the surgery were evaluated by measurements before, immediately and 24 months after the surgery using the following parameters: coronal spinal Cobb angle, apex rotation and kyphosis of the spine and the intra-canal rib head position. Post-operative complications, surgery time and blood loss were also evaluated. RESULTS: Patients were followed up for at least 24 months post-operatively. The three dimensional spinal deformity was significantly improved and the intra-canal rib head was significantly extracted from the canal immediately after the surgery. At follow-up 24 months after surgery, solid fusions were achieved along the fusion segments, and the deformity corrections and rib head positions were well maintained. There were no surgery-related complications any time after the surgery. CONCLUSIONS: Systematic examinations are needed to identify patients with Type I neurofibromatosis scoliosis with rib head dislocation into the canal who can be treated by posterior-only spinal fusion without rib head resection.

Sichuan basin, situated in the west of China, is the fourth biggest basin in China. In order to describe a systematic study of the cry2-type genes resources from Bacillus thuringiensis strains of Sichuan basin, a total of 791 Bacillus thuringiensis strains have been screened from 2650 soil samples in different ecological regions. The method of PCR-restriction fragment length polymorphism (PCR-RFLP) was used to identify the type of cry2 genes. The results showed that 322 Bacillus thuringiensis strains harbored cry2-type genes and four different RFLP patterns were found. The combination of cry2Aa/cry2Ab genes was the most frequent (90.4%), followed by cry2Aa (6.8%) and cry2Ab alone (2.5%), and only one novel type of cry2 gene was cloned from one isolate (JF19-2). The full-length of this novel gene was obtained by the method of thermal asymmetric interlaced PCR (Tail-PCR), which was designated as cry2Ag1 (GenBank No. ACH91610) by the Bt Pesticide Crystal Protein Nomenclature Committee. In addition, the result of scanning electron microscopic (SEM) observation showed that these strains had erose, spherical, bipyramidal, and square crystal. And the results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) demonstrated that these strains harbored about one to three major proteins. These strains exhibited a wide range of insecticidal spectrum toxic to Aedes aegypti (Diptera) and Pieris rapae Linnaeus, 1758 (Lepidoptera). Particularly, JF19-2 contained cry2Ag gene had the highest insecticidal activity. All these researches mentioned above revealed the diversity and particularity of cry2-type gene resources from Bacillus thuringiensis strains in Sichuan basin.

Electrodeposition of polypyrrole films on aluminum from aqueous solutions containing p-toluene sulfonic acid and pyrrole was performed by cyclic voltammetry and galvanostatic technique. The influence of applied current density on the morphology of the films was studied by Scanning Electron Microscopy. The films displayed a cauliflower-like structure consisting of micro-spherical grains. This structure is related to dopand intercalation in the polymeric chain. Films deposited at higher current density were more susceptible to the formation of pores and defects along the polymeric chain than films deposited at lower current density. These pores allow the penetration of aggressive species, thereby favoring the corrosion process.

beta-dicarbonyl compounds were oxidized electrocatalytically, with fragmentation and loss of "ch2", using ceric methanesulphonate as a mediator. 2,4-pentanedione yields acetic acid (90%), methyl acetoacetate yields acetic acid (84%) plus methanol and dimethyl malonate yields methanol (64%). For 1,3-diphenyl-1,3-propanedione and 1,3-cyclohexanedione, benzoic acid (61% yield) and glutaric acid (75% yield) were obtained, respectively. Methyl cyanoacetate and malononitrile were inert.

Estudou-se em Ribeirão Preto, SP, Brasil, no período de 1º de junho de 1978 a 31 de maio de 1979, 98% do universo de nascidos vivos, totalizando 8878 crianças nascidas de parto único, sendo 6750 procedentes de Ribeirão Preto. Observou-se um aumento da proporção de mães adolescentes em Ribeirão Preto (14,1%) quando comparada com estudo realizado 10 anos antes (11,7%). A idade materna menor de 20 anos esteve associada com os indicadores mais desfavoráveis para a saúde perinatal, no que diz respeito à atenção médica à gestação e ao parto. Essa situação ficou mais evidente entre as mães adolescentes de classes sociais menos favorecidas, revelando que o grupo de mães adolescentes não é homogêneo, mas apresenta diferentes proporções de risco para a saúde perinatal de acordo com as frações de classe social que existem no seu interior.

Ninety-eight percent of all live births occuring in the city of Ribeirão Preto, state of São Paulo (Brazil), from June 1, 1978 to May 30, 1979 were studied, for a total of 8,878 single-delivery infants, 6,750 of whom were from this town. An increase in the proportion of teenage mothers in Ribeirão Preto (14.1%) was observed in relation to a study carried out ten years before (11.7%). Maternal age of less than 20 years was associated with more unfavorable perinatal health indicators with respect to medical care and delivery. This situation was more evident among teenage mothers from underprivileged social classes, showing that the group of teenage mothers is not homogeneous but presents different risk rates for perinatal health according to the social strata of which the group is composed.

Estudou-se em Ribeirão Preto, SP, Brasil, no período de 1º de junho de 1978 a 31 de maio de 1979, 98% do universo de nascidos vivos, totalizando 8878 crianças nascidas de parto único, sendo 6750 procedentes de Ribeirão Preto. Observou-se um aumento da proporção de mães adolescentes em Ribeirão Preto (14,1%) quando comparada com estudo realizado 10 anos antes (11,7%). A idade materna menor de 20 anos esteve associada com os indicadores mais desfavoráveis para a saúde perinatal, no que diz respeito à atenção médica à gestação e ao parto. Essa situação ficou mais evidente entre as mães adolescentes de classes sociais menos favorecidas, revelando que o grupo de mães adolescentes não é homogêneo, mas apresenta diferentes proporções de risco para a saúde perinatal de acordo com as frações de classe social que existem no seu interior.

Ninety-eight percent of all live births occuring in the city of Ribeirão Preto, state of São Paulo (Brazil), from June 1, 1978 to May 30, 1979 were studied, for a total of 8,878 single-delivery infants, 6,750 of whom were from this town. An increase in the proportion of teenage mothers in Ribeirão Preto (14.1%) was observed in relation to a study carried out ten years before (11.7%). Maternal age of less than 20 years was associated with more unfavorable perinatal health indicators with respect to medical care and delivery. This situation was more evident among teenage mothers from underprivileged social classes, showing that the group of teenage mothers is not homogeneous but presents different risk rates for perinatal health according to the social strata of which the group is composed.