ABSTRACT Introduction: Although still rare, pulmonary embolism (PE) in children has been increasing over the years. Data regarding this group of patients are still sparse, which contributes to the lack of standardized prophylaxis protocols and the misdiagnosis. This study aimed to determine the incidence of pediatric PE at a Brazilian tertiary hospital, describe clinical characteristics and identify possible risk factors. We also analyzed the diagnosis and management of PE. Methods: This was a retrospective review of tertiary Brazilian single-center data of all pediatric patients (0 – 18 years) with acute PE, diagnosed radiologically, from September 2009 to May 2019. Results: The incidence of PE was 3.3 cases per 10,000 hospitalized children. All the twenty-three cases had some risk factor identified and sixteen of them (69.5%) had more than one risk factor. The most important were central venous catheter (39.1%), malignancy (34.8%) and recent surgery (34.8%). Among the children with identifiable symptoms (69.5%), the most common was dyspnea (56.2%). Only one patient did not receive antithrombotic therapy because of the high bleeding risk and most patients (70.6%) were treated for 3 to 6 months. Among the nineteen patients alive at the end of the six-month follow-up, ten (52.6%) repeated the PE image control. Seven of them (70.0%) had complete or partial resolution of the thrombosis and none had worsening images. Conclusion: Our lower incidence than that of the current literature may reflect underdiagnosis due to low suspicion of PE. At least one risk factor was identified in all patients, which emphasizes the importance of increasing awareness of high-risk children. Introduction rare (PE years sparse misdiagnosis hospital factors Methods singlecenter single center 0 ( 1 radiologically 200 2019 Results 33 3. 10000 10 000 10,00 twentythree twenty three 69.5% 695 69 5 (69.5% 39.1%, 391 39.1% , 39 (39.1%) 34.8% 348 34 8 (34.8% 34.8%. . 69.5%, 56.2%. 562 56.2% 56 2 (56.2%) 70.6% 706 70 (70.6% months sixmonth six month followup, followup follow up, up follow-up 52.6% 526 52 (52.6% control 70.0% 700 (70.0% images Conclusion highrisk 20 201 1000 00 10,0 69.5 (69.5 39.1 (39.1% 34.8 (34.8 56.2 (56.2% 70.6 7 (70.6 52.6 (52.6 70.0 (70.0 100 10, 69. (69. 39. (39.1 34. (34. 56. (56.2 70. (70. 52. (52. (69 (39. (34 (56. (70 (52 (6 (39 (3 (56 (7 (5