RESUMO: O objetivo do presente estudo foi avaliar alterações clínicas, cardiorrespiratórias e ecodopplercardiográficas, bem como o nível de sedação em coelhos sedados com midazolam e morfina combinadas, ou não, com dexmedetomidina. O design do estudo foi experimental controlado randomizado cego, com 16 coelhos adultos machos Nova Zelândia, pesando 3,1 ± 0,3 Kg. Os animais foram sedados aleatoriamente com um dos seguintes tratamentos: MIDA (n = 8): 1 mg/kg de midazolam e 2 mg/kg de morfina; DEX (n = 8) 25 mcg/kg de dexmedetomidina, 2 mg/kg de morfina e 1 mg/kg de midazolam; Latência, sedação e períodos de recuperação, escores de sedação, FC, f, SpO2, PAS, PAM, PAD, ToC, foram mensurados e ecoDopplercardiografia foi realizada. Os períodos de latência foram 7.3 ± 1.6 minutos no grupo DEX e 10.9 ± 5.0 minutos no grupo MIDA (P = 0,112). A duração da sedação foi de 122.4 ± 14 minutos no grupo DEX e 71.2 ± 32 minutos no grupo MIDA (P = 0,005). Os tempos totais de recuperação foram de 35.7 ± 17.7 minutos no grupo DEX e 32.5 ± 25.3 minutos no MIDA (P = 0,743). Os escores de sedação obtidos do grupo DEX foram estatisticamente superiores aos do grupo MIDA durante todas as observações (de 5 a 40 minutos). A redução dos valores de FC, PAS, PAM e PAD foi observada em ambos os grupos, em relação ao momento baseline, e foram significativamente menores no grupo DEX quando comparado ao MIDA. Alterações ecodopplercardiográficas mínimas foram observadas ambos os grupos. A adição de dexmedetomidina à associação midazolam/morfina aumentou o nível, a qualidade e a duração do protocolo sedativo. Ambos os protocolos causaram alterações cardiorrespiratórias bem toleradas em animais normais e com mínimas alterações na função miocárdica. RESUMO clínicas combinadas não cego Zelândia 31 3 3, 03 0 0, Kg tratamentos n 8 mgkg mg kg mcgkg mcg Latência FC f SpO2 SpO PAS ToC realizada 73 7 7. 6 1. 109 10 9 10. 50 5. P 0,112. 0112 0,112 . 112 0,112) 1224 122 4 122. 712 71 71. 0,005. 0005 0,005 005 0,005) 357 35 35. 177 17 17. 325 32. 253 25. 0,743. 0743 0,743 743 0,743) minutos. minutos) grupos baseline midazolammorfina sedativo miocárdica 011 0,11 11 12 000 0,00 00 074 0,74 74 01 0,1 0,0 07 0,7

ABSTRACT: The objective of the present study was to evaluate clinical, cardiorespiratory, and Doppler echocardiographic changes in rabbits sedated with midazolam and morphine combined with or without dexmedetomidine. This study was a blinded, randomized, controlled experiment that included 16 adult male New Zealand rabbits weighing 3.1 ± 0.3 kg. The animals were sedated using one of the following protocols: 1 mg/kg midazolam and 2 mg/kg morphine (MIDA, n = 8), or 25 mg/kg dexmedetomidine, 2 mg/kg morphine and 1 mg/kg midazolam (DEX, n = 8). Sedation latency, duration of the sedation and recovery period, sedation scores, heart rate (HR), respiratory rate (f), peripheral oxygen saturation (SpO2), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), and recta temperature were recorded, and Doppler echocardiography was performed. Latency periods were 7.3±1.6 min in the DEX group and 10.9 ± 5.0 min in the MIDA group (P = 0.112). Sedation duration was 122.4±14 min in the DEX group and 71.2 ± 32 min in the MIDA group (P = 0.005), whereas recovery time was 35.7±17.7 min in the DEX group and 32.5 ± 25.3 min in the MIDA group (P = 0.743). The sedation scores for the DEX group were significantly higher than those for the MIDA group throughout the monitoring period. Reductions in HR, SAP, MAP, and DAP values were observed in both groups relative to baseline values, and were significantly lower in the DEX group compared to the MIDA group. Minimal Doppler echocardiographic changes were observed. Dexmedetomidine used in combination with midazolam and morphine incremented the quality and duration of sedation in rabbits. Both protocols elicited cardiorespiratory changes that were well-tolerated, with minimal changes in myocardial function. ABSTRACT clinical dexmedetomidine blinded randomized 31 3 3. 03 0 0. kg mgkg mg MIDA, (MIDA 8, 8 , 8) DEX, (DEX 8. . latency period HR (HR) f, f (f) SpO2, SpO2 SpO (SpO2) SAP (SAP) DAP, (DAP) MAP (MAP) recorded performed 7316 7 6 7.3±1. 109 10 9 10. 50 5 5. P 0.112. 0112 0.112 112 0.112) 122414 122 4 14 122.4±1 712 71 71. 0.005, 0005 0.005 005 0.005) 357177 35 17 35.7±17. 325 32. 253 25. 0.743. 0743 0.743 743 0.743) welltolerated, welltolerated well tolerated, tolerated well-tolerated function (HR (f (SpO2 (SAP (DAP (MAP 731 7.3±1 011 0.11 11 12241 12 122.4± 000 0.00 00 35717 35.7±17 074 0.74 74 (SpO 73 7.3± 01 0.1 1224 122.4 0.0 3571 35.7±1 07 0.7 7.3 122. 357 35.7± 7. 35.7 35.

Resumo Este artigo é uma atualização do tema espondilólise e espondilolistese em atletas, do diagnóstico ao tratamento, baseando-se na experiência dos nossos serviços juntamente com uma revisão da literatura. atletas tratamento baseandose baseando se literatura

Abstract This article is an update on spondylolysis and spondylolisthesis in athletes, from diagnosis to treatment, based on our service experience and a literature review. athletes treatment review

ABSTRACT Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses within a 28-day interval. IC received two additional BNT162b2 doses and H received a third BNT162b2 dose (booster). Blood samples were collected at baseline, 28 days after each dose, pre-booster and at the trial end. We used three serological tests to detect antibodies to SARS-CoV-2 nucleocapsid (N), trimeric spike (S), and receptor binding domain (RBD). Outcomes included seroconversion rates (SCR), geometric mean titers (GMT) and GMT ratio (GMTR). A total of 241 IC and 100 H adults participated in the study. After two CoronaVac doses, IC had lower SCR than H: anti-N, 33.3% vs 79%; anti-S, 33.8% vs 86%, and anti-RBD, 48.5% vs 85%, respectively. IC also showed lower GMT than H: anti-N, 2.3 vs 15.1; anti-S, 58.8 vs 213.2 BAU/mL; and anti-RBD, 22.4 vs 168.0 U/mL, respectively. After the 3rd and 4th BNT162b2 doses, IC had significant anti-S and anti-RBD seroconversion, but still lower than H after the 3rd dose. After boosting, GMT increased in IC, but remained lower than in the H group. CoronaVac two-dose schedule immunogenicity was lower in IC than in H. BNT162b2 heterologous booster enhanced immune response in both groups. COVID19 COVID 19 COVID-1 scarce BNTb BNT b BNT162b (IC (H SOT, SOT , (SOT) cancer comparison 28day day interval booster. . (booster) baseline 2 prebooster pre end SARSCoV2 SARSCoV SARS CoV SARS-CoV- N, N (N) S, S (S) RBD. RBD (RBD) SCR, (SCR) (GMT GMTR. GMTR (GMTR) 24 10 study antiN, antiN anti anti-N 333 33 3 33.3 79% 79 antiS, antiS 338 8 33.8 86 86% antiRBD, antiRBD RBD, 485 48 5 48.5 85 85% respectively 23 2. 15.1 151 15 1 588 58 58. 2132 213 213. BAU/mL BAUmL BAU mL 224 22 4 22. 1680 168 0 168. UmL U U/mL rd th boosting twodose groups COVID1 COVID- (SOT (booster SARS-CoV (N (S (RBD (SCR (GMTR 33. 7 48. 15. 21 16

Resumo Neste artigo propõe-se avaliar a eficiência das escolas estaduais do Ensino Médio da região 4 do município de Fortaleza (CE) por meio dos resultados obtidos no Spaece, nas edições de 2022 e 2023. Para tanto, foi utilizado o método quadripolar e a modelagem por meio do Data Envelopment Analysis (DEA), com retornos variáveis de escala (Variable Returns to Scale - VRS), modelo BCC-O orientado pelos outputs, introduzido por Banker, Charnes e Cooper (1984) para verificar a eficiência das escolas estaduais da região 4 do município de Fortaleza. Avaliou-se a proficiência em língua portuguesa e matemática das edições de 2022 e 2023 do Spaece das 21 escolas estaduais da região 4. Os resultados após aplicação do software OSDEA-GUI-v0.2.jar revelaram que das 21 escolas, 9 escolas foram consideradas com valor objetivo 1 eficiente tanto em língua portuguesa como em matemática. A partir do Benchmark foram identificadas 2 escolas com maior incidência como DMU referência e levantado as melhores práticas dessas escolas que podem servir de exemplo para as outras escolas menos eficientes. propõese propõe se CE (CE 202 DEA, DEA , (DEA) Variable VRS, VRS VRS) BCCO BCC O outputs Banker 1984 (1984 Avaliouse Avaliou OSDEAGUIv0.2.jar OSDEAGUIv02jar OSDEAGUIvjar OSDEA GUI v0.2.jar v0 jar v eficientes 20 (DEA 198 (198 OSDEAGUIv0 OSDEAGUIv v02jar vjar 19 (19 (1 (

Abstract This article aims to evaluate the efficiency of state high schools in region 4 of the municipality of Fortaleza (CE) using the results obtained in the Spaece in the 2022 and 2023 editions. The quadrupole method and Data Envelopment Analysis (DEA) modeling with Variable Returns to Scale (VRS), an output-oriented BCC-O model introduced by Banker, Charnes, and Cooper (1984), were used to verify the efficiency of state schools in region 4 of the municipality of Fortaleza. The proficiency in Portuguese and Mathematics in the 2022 and 2023 editions of the Spaece of 21 state schools in region 4 was evaluated. After applying the OSDEA-GUI-v0.2.jar software, the results revealed that of the 21 schools, 09 schools were considered to have an objective value of 1 efficient in both Portuguese and Mathematics. Based on the Benchmark, 2 schools with the highest incidence as reference DMUs and the best practices of these schools were identified, which can serve as an example for the other less efficient schools. CE (CE 202 DEA (DEA VRS, VRS , (VRS) outputoriented output oriented BCCO BCC O Banker Charnes 1984, 1984 (1984) evaluated OSDEAGUIv0.2.jar OSDEAGUIv02jar OSDEAGUIvjar OSDEA GUI v0.2.jar v0 jar v software 0 Benchmark identified 20 (VRS 198 (1984 OSDEAGUIv0 OSDEAGUIv v02jar vjar 19 (198 (19 (1 (

Resumen Este artículo tiene como objetivo evaluar la eficiencia de las escuelas secundarias estatales de la región 4 del municipio de Fortaleza (CE) a partir de los resultados obtenidos en el Spaece en las ediciones de 2022 y 2023. Para ello, se utilizó el método cuádruple y la modelización de Análisis Envolvente de Datos (DEA) con Rendimientos Variables a Escala (RVA), un modelo BCC-O orientado al output introducido por Banker, Charnes y Cooper (1984), para verificar la eficiencia de las escuelas estatales de la región 4 del municipio de Fortaleza. Se evaluó la competencia en portugués y matemáticas de las ediciones de 2022 y 2023 del Spaece de las 21 escuelas estatales de la región 4. Los resultados tras aplicar el software OSDEA-GUI-v0.2.jar revelaron que, de las 21 escuelas, 09 se consideraron con un valor objetivo de 1 eficientes tanto en portugués como en matemáticas. A partir del Benchmark se identificaron 2 escuelas con mayor incidencia como DMUs de referencia y se analizaron las mejores prácticas de estas escuelas, que pueden servir de ejemplo para las demás escuelas menos eficientes. CE (CE 202 ello DEA (DEA RVA, RVA , (RVA) BCCO BCC O Banker 1984, 1984 (1984) OSDEAGUIv0.2.jar OSDEAGUIv02jar OSDEAGUIvjar OSDEA GUI v0.2.jar v0 jar v 0 20 (RVA 198 (1984 OSDEAGUIv0 OSDEAGUIv v02jar vjar 19 (198 (19 (1 (

Abstract The present study aimed to evaluate the effectiveness of two doses of CoronaVac in preventing SARS-CoV-2 symptomatic disease with virological confirmation, as well as in the prevention of COVID-19 moderate and severe cases. A test-negative unmatched case-control design was used, in which cases were patients with suspected COVID-19 (presenting at least two of the following symptoms: fever, chills, sore throat, headache, cough, runny nose, olfactory or taste disorders) with virological confirmation, and controls were those whose SARS-CoV-2 test was negative. As for exposure, participants were classified as unvaccinated, or vaccinated with a complete schedule. Suspected COVID-19 cases were identified from March to November 2021, in two cities located in the State of São Paulo, Brazil. All participants signed the Informed Consent Form before enrollment. RT-PCR results and vaccination data were obtained from the local surveillance systems. Up to two phone calls were made to obtain information on the outcome of the cases. A total of 2981 potential participants were screened for eligibility, of which 2163 were included, being 493 cases and 1670 controls. Vaccination, age, the reported contact with a COVID-19 suspected or confirmed case in the 14 days before symptoms onset, and the educational level were the variables independently associated with the outcome. The adjusted vaccine effectiveness for symptomatic COVID-19 (AVE) was 39.0 % (95 % CI 6.0-60.0 %). The AVE in the prevention of moderate and severe disease was 91.0 % (95 % CI 76.0-97.0 %). Our results were influenced by the waning of the Gamma variant, in the second trimester of 2021, followed by the increase in vaccination coverage, and a drop in the number of cases in the second half of the year. The study demonstrated the high effectiveness of CoronaVac in preventing moderate/severe COVID-19 cases. SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- confirmation COVID19 COVID 19 COVID-1 testnegative negative casecontrol control used presenting fever chills throat headache cough nose disorders exposure unvaccinated schedule 2021 Paulo Brazil enrollment RTPCR RT PCR systems 298 eligibility 216 included 49 167 Vaccination age 1 onset (AVE 390 39 0 39. 95 (9 6.060.0 60600 6.0 60.0 6 60 6.0-60. %. . %) 910 91 91. 76.097.0 760970 76.0 97.0 76 97 76.0-97. variant coverage year moderatesevere SARS-CoV COVID1 COVID- 202 29 21 4 16 3 9 ( 060 6.060. 6060 6. 600 60. 6.0-60 097 76.097. 76097 760 76. 970 97. 7 76.0-97 20 06 6.060 606 6.0-6 09 76.097 7609 76.0-9 6.06 6.0- 76.09 76.0-

Annual world production of sisal is estimated to be 400,000 tons, but the processing of sisal fiber generates around 160,000 tons of waste per year. The sisal bagasse is discarded, even though it is about 60% carbohydrates in its structure. Therefore, this work seeks to add value to sisal bagasse through the production of cellulose acetate membranes aimed at removing inhibitors from the fermentation process. The membrane was developed using a cellulose acetate polymer synthesized from cellulose isolated from sisal bagasse. Alkaline and acid pre-treatments resulted in 90% pure cellulose. The obtained cellulose acetate was confirmed by infrared spectroscopy. In the synthesis of the membranes, the influence of agitation time and temperature of the bath on the selectivity and porosity were evaluated in four tests, the third condition stood out with porosity of 26.23% and selectivity of 94.51% in the removal of the furfural and 36.62% of the acetic acid. 400000 400 000 400,00 160000 160 160,00 year discarded 60 structure Therefore process pretreatments pre treatments 90 spectroscopy tests 2623 26 23 26.23 9451 94 51 94.51 3662 36 62 36.62 40000 40 00 400,0 16000 16 160,0 6 9 262 2 26.2 945 5 94.5 366 3 36.6 4000 4 0 400, 1600 1 160, 26. 94. 36.

Resumen El metanálisis consiste en un conjunto de técnicas estadísticas que tiene como objetivo integrar los resultados de dos o más estudios primarios. Permite producir estimaciones puntuales y de intervalo de algún parámetro de población, generalmente una medida del tamaño del efecto. Este artículo presenta conceptos fundamentales sobre el metanálisis y sus aplicaciones para psicólogos y estudiantes de psicología. El artículo: (1) introduce la lógica del metanálisis, sus potencialidades y las críticas que se le dirigen; (2) presenta dos modelos de metanálisis comúnmente utilizados por los investigadores; y (3) aborda dos temas importantes para la correcta interpretación de los resultados: heterogeneidad y análisis de subgrupos. Un ejemplo ficticio ilustra los conceptos a lo largo del artículo. Los Materiales Suplementarios contienen ecuaciones de los modelos presentados en el texto, resultados comentados de una síntesis metanalítica, código en el lenguaje R para reproducir los resultados y las figuras de este artículo, y una breve lista comentada de fuentes adicionales. primarios población efecto psicología 1 (1 dirigen 2 (2 investigadores 3 (3 subgrupos texto metanalítica adicionales (

Resumo Metanálise consiste em um conjunto de técnicas estatísticas que visa integrar os resultados de dois ou mais estudos primários. Ela permite produzir estimativas pontuais e intervalares de algum parâmetro populacional, geralmente uma medida de tamanho de efeito. Este artigo tem como objetivo apresentar conceitos fundamentais sobre metanálise e suas aplicações para psicólogos e estudantes de psicologia. O artigo: (1) introduz a lógica da metanálise, seus potenciais e as críticas a ela endereçadas; (2) apresenta dois modelos de metanálise comumente usados por pesquisadores; e (3) aborda dois tópicos importantes para a interpretação correta dos resultados: heterogeneidade e análise de subgrupos. Um exemplo fictício ilustra os conceitos ao longo do artigo. Os Materiais Suplementares contêm equações dos modelos apresentados no texto, resultados comentados de uma síntese metanalítica, código na linguagem R para reproduzir resultados e figuras desse artigo e uma breve lista comentada de fontes adicionais sobre metanálise. primários populacional efeito psicologia 1 (1 endereçadas 2 (2 pesquisadores 3 (3 subgrupos texto metanalítica (

Abstract Meta-analysis consists of a set of statistical techniques that aims to combine the results of two or more primary studies. It enables the calculation of point and interval estimates of some population parameter, usually a measure of effect size. The aim of this article is to introduce fundamental concepts of meta-analysis and its applications for psychologists and psychology students. The article: (1) introduces the logic of meta-analysis, its uses and common criticisms levied against it; (2) presents two computational models of meta-analysis commonly used by researchers; and (3) addresses two issues associated with the correct interpretation of results from meta-analyses: heterogeneity and subgroup analysis. A worked example illustrates the concepts throughout the article. The Supplementary Materials contain a worked example of the models presented in the text, a script in R language that allows the reader to reproduce the results, and a commented list of additional sources. Metaanalysis Meta analysis studies parameter size metaanalysis meta students 1 (1 metaanalysis, analysis, it 2 (2 researchers 3 (3 metaanalyses analyses meta-analyses text sources (

RESUMEN Objetivo: analizar la tendencia temporal de la mortalidad por agresiones en el Estado de Acre, según el sexo. Método: estudio ecológico de análisis de series temporales con datos extraídos del Sistema de Información de Mortalidad correspondientes a las muertes causadas por agresión (CIE X85 a Y09), ocurridas en el estado de Acre, Brasil, de 2000 a 2019. El análisis de datos se realizó utilizando el Modelo de análisis lineal generalizado de Prais-Winsten con un nivel de significación estadística del 5%. Resultados: hubo mayor mortalidad por causas externas en los adultos del sexo masculino. Se observó una tendencia creciente en los homicidios en el sexo masculino con una variación porcentual anual del 3,13% (p=0,002) y en ambos sexos del 2,92% (p=0,003). Conclusión: Esta información indica que hay una necesidad emergente de combatir y prevenir la violencia. Se destaca la importancia del profesional de enfermería en la movilización social y participación en la reformulación de políticas públicas contra la violencia. Objetivo Acre Método CIE X X8 Y09, Y09 Y , Y09) Brasil 200 2019 PraisWinsten Prais Winsten 5 5% Resultados 313 3 13 3,13 p=0,002 p0002 p 0 002 (p=0,002 292 2 92 2,92 p=0,003. p0003 p=0,003 . 003 (p=0,003) Conclusión violencia Y0 20 201 31 1 3,1 p=0,00 p000 00 (p=0,00 29 9 2,9 (p=0,003 3, p=0,0 p00 (p=0,0 2, p=0, p0 (p=0, p=0 (p=0 p= (p= (p

RESUMO Objetivo: analisar a tendência temporal de mortalidade por agressões no Estado do Acre, de acordo com o sexo. Método: estudo ecológico de análise de série temporal com dados extraídos do Sistema de Informações de Mortalidade correspondentes às mortes provocadas por agressões (CID X85-Y09), ocorridos no estado do Acre - Brasil, de 2000 a 2019. A análise dos dados foi realizada utilizando o modelo de análise linear generalizada de Prais-Winsten com nível de significância estatística de 5%. Resultados: houve maior mortalidade por causas externas em indivíduos adultos do sexo masculino. Foi observada uma tendência crescente dos homicídios para o sexo masculino com variação percentual anual de 3,13%, p=0,002 e para ambos os sexos de 2,92%, p=0,003. Conclusão: essas informações apontam a necessidade emergente de combate e prevenção das violências. Destaca-se a importância do profissional de enfermagem na mobilização social e participação na reformulação de políticas públicas de combate a violência. Objetivo Método CID X85Y09, X85Y09 XY X85 Y09 , X Y X85-Y09) Brasil 200 2019 PraisWinsten Prais Winsten 5 5% Resultados 313 3 13 3,13% p0002 p 0 002 p=0,00 292 2 92 2,92% p0003 003 p=0,003 Conclusão violências Destacase Destaca se violência X85Y0 X8 Y0 X85-Y09 20 201 31 1 3,13 p000 00 p=0,0 29 9 2,92 X85Y X85-Y0 3,1 p00 p=0, 2,9 X85-Y 3, p0 p=0 2, p=

ABSTRACT Objective: to analyze the time trend of mortality due to assaults in the state of Acre, according to gender. Method: an ecological study of time series analysis with data extracted from the Mortality Information System for Deaths Caused by Assaults (ICD X85-Y09) in the state of Acre, Brazil, from 2000 to 2019. Data analysis was performed using the Prais-Winsten generalized linear analysis model with a 5% statistical significance level. Results: there was higher mortality due to external causes in male adults. A growing trend of homicides was observed for the male gender, with an annual percent change of 3.13% (p=0.002); for both genders, the annual percent change was 2.92% (p=0.003). Conclusion: these findings indicate the emerging need to fight against and prevent acts of violence. The importance of Nursing professionals in social mobilization and participation in the reformulation of public policies to combat violence is emphasized. Objective Acre gender Method ICD X85Y09 XY X85 Y09 X Y X85-Y09 Brazil 200 2019 PraisWinsten Prais Winsten 5 level Results adults 313 3 13 3.13 p=0.002 p0002 p 0 002 (p=0.002) genders 292 2 92 2.92 p=0.003. p0003 p=0.003 . 003 (p=0.003) Conclusion emphasized X85Y0 X8 Y0 X85-Y0 20 201 31 1 3.1 p=0.00 p000 00 (p=0.002 29 9 2.9 (p=0.003 X85Y X85-Y 3. p=0.0 p00 (p=0.00 2. p=0. p0 (p=0.0 p=0 (p=0. p= (p=0 (p= (p

ABSTRACT The objective of this study was to evaluate whether the addition of the enzymes phytase and xylanase, isolated or associated, in the liquid form after feed pelletization could improve energy utilization and digestibility of calcium and phosphorus by broiler chickens. Three experiments were performed using 120 birds each, divided into five treatments with eight replicates per group (n = 3), identified as: experiment 1 (xylanase: control, 1000 IU, 1500 IU, 2000 IU, 2500 IU), experiment 2 (phytase: control, 500 FTU, 1000 FTU, 1500 FTU, 2000 FTU), experiment 3 (xylanase + phytase: control, 3000 IU + 500 FTU, 3000 IU + 1000 FTU, 3000 IU + 1500 FTU, 3000 IU + 2000 FTU). Samples for digestibility tests were collected at 14 to 21 days of age. Therefore, the inclusion of liquid phytase and liquid phytase + xylanase after pelletization in broiler diets has become a relevant way to reduce the inclusion of inorganic P, which can reduce the cost of feed and P excretion in the environment. Furthermore, it is an interesting strategy to avoid enzyme denaturation in the pelleting process. associated chickens 12 each n 3, , 3) as control 100 150 200 250 IU) (phytase 50 FTU FTU) 300 FTU. . age Therefore environment Furthermore process 10 15 20 25 5 30

Abstract Indicator species are frequently used to monitor restoration areas. However, species of conservation concern are usually absent in highly fragmented landscapes, making the selection of indicator species a challenging task. Here, we select indicator species of birds and mammals to be used for the evaluation of restoration sites in a highly fragmented landscape, the Capivara-Taquaruçu Dams region located in north Paraná, Brazil. By using the Index of Biotic Integrity (IBI), we show that the Capivara-Taquaruçu Dams landscape has low IBI values and bird richness when compared with two other landscapes in the north of Paraná. Therefore, we used the Individual Indicate Value to identify birds and mammals associated with forest fragments in the Capivara-Taquaruçu Dams landscape. Six bird and four mammal species were selected as indicators of forest fragments, none of which were of conservation concern. However, monitoring of these species could help evaluate the recovery of restoration sites in the Capivara-Taquaruçu Dams region. Lastly, several species of birds and mammals were frequently recorded in the restoration sites, including vulnerable species such as the lowland tapir (Tapirus terrestris). This is indicative that restoration sites can be important habitats in highly fragmented landscapes despite the loss of biodiversity. areas However task Here CapivaraTaquaruçu Capivara Taquaruçu Paraná Brazil IBI, , (IBI) Therefore Lastly Tapirus terrestris. terrestris . terrestris) biodiversity (IBI

Resumo O município de São Paulo historicamente foi marcado pela heterogeneidade da implementação pela coexistência de modelos conflitivos de gestão do SUS e de atenção na Atenção Primária à Saúde (APS). Consolidou-se a administração via contratos de gestão dos serviços de saúde, associada a uma lógica produtivista. Durante a pandemia de COVID-19, as fragilidades de uma APS seletiva tendem a ser pronunciadas. Assim, o presente artigo tem como objetivo analisar a gestão do trabalho e o cuidado na APS durante a pandemia de COVID-19 no município de São Paulo, em pesquisa qualitativa multicêntrica, ancorada no referencial teórico Paideia. Foram realizadas 31 entrevistas em profundidade com usuários e trabalhadores da APS e observação participante. Observou-se postura autoritária e gerencialista da gestão municipal na condução das respostas, com pouco espaço para escuta e diálogo. Notou-se enfraquecimento dos espaços coletivos e do vínculo entre serviço e comunidade; burocratização e precarização dos processos de trabalho e desmantelamento do NASF. Neste cenário, o cuidado caracterizou-se pela redução expressiva da clínica ampliada, compartilhada e pelo distanciamento das diretrizes da APS de base territorial e comunitária. APS. . (APS) Consolidouse Consolidou se saúde produtivista COVID19, COVID19 COVID 19, 19 pronunciadas Assim COVID-1 multicêntrica Paideia 3 participante Observouse Observou respostas diálogo Notouse Notou comunidade NASF cenário caracterizouse caracterizou ampliada comunitária (APS COVID1 1 COVID-

Abstract The municipality of São Paulo has historically been marked by a heterogeneous implementation and coexistence of conflicting models of SUS management and Primary Health Care (PHC). The administration of health services management contracts was consolidated and associated with a productivist rationale. The selective PHC weaknesses tend to be pronounced during the COVID-19 pandemic. Thus, the present article aims to analyze work management and care in PHC during the COVID-19 pandemic in the municipality of São Paulo through a multicenter qualitative research anchored in the Paideia theoretical framework. We conducted 31 in-depth interviews with PHC clients and workers, along with participant observation. We noted the municipal management’s authoritarian and managerialist stance when conducting the responses, with little room for listening and dialogue. We identified weakened collective spaces and service-community bond, bureaucratization and precariousness of work processes, and NASF’s dismantling. In this setting, care was characterized by significantly reducing the expanded and shared clinical practice and the distancing from the territorial and community-based PHC guidelines. PHC. . (PHC) rationale COVID19 COVID 19 COVID-1 Thus framework 3 indepth depth workers observation managements s responses dialogue servicecommunity service community bond processes NASFs NASF dismantling setting communitybased based guidelines (PHC COVID1 1 COVID-

Resumo O município de São Paulo historicamente foi marcado pela heterogeneidade da implementação pela coexistência de modelos conflitivos de gestão do SUS e de atenção na Atenção Primária à Saúde (APS). Consolidou-se a administração via contratos de gestão dos serviços de saúde, associada a uma lógica produtivista. Durante a pandemia de COVID-19, as fragilidades de uma APS seletiva tendem a ser pronunciadas. Assim, o presente artigo tem como objetivo analisar a gestão do trabalho e o cuidado na APS durante a pandemia de COVID-19 no município de São Paulo, em pesquisa qualitativa multicêntrica, ancorada no referencial teórico Paideia. Foram realizadas 31 entrevistas em profundidade com usuários e trabalhadores da APS e observação participante. Observou-se postura autoritária e gerencialista da gestão municipal na condução das respostas, com pouco espaço para escuta e diálogo. Notou-se enfraquecimento dos espaços coletivos e do vínculo entre serviço e comunidade; burocratização e precarização dos processos de trabalho e desmantelamento do NASF. Neste cenário, o cuidado caracterizou-se pela redução expressiva da clínica ampliada, compartilhada e pelo distanciamento das diretrizes da APS de base territorial e comunitária.

Abstract The municipality of São Paulo has historically been marked by a heterogeneous implementation and coexistence of conflicting models of SUS management and Primary Health Care (PHC). The administration of health services management contracts was consolidated and associated with a productivist rationale. The selective PHC weaknesses tend to be pronounced during the COVID-19 pandemic. Thus, the present article aims to analyze work management and care in PHC during the COVID-19 pandemic in the municipality of São Paulo through a multicenter qualitative research anchored in the Paideia theoretical framework. We conducted 31 in-depth interviews with PHC clients and workers, along with participant observation. We noted the municipal management’s authoritarian and managerialist stance when conducting the responses, with little room for listening and dialogue. We identified weakened collective spaces and service-community bond, bureaucratization and precariousness of work processes, and NASF’s dismantling. In this setting, care was characterized by significantly reducing the expanded and shared clinical practice and the distancing from the territorial and community-based PHC guidelines.

Resumo: Este artigo investigou se as características institucionais das universidades brasileiras estão refletidas em suas declarações de missão. Com suporte em técnicas de linguística de corpus, foram identificados os termos mais frequentes e suas coocorrências, assim como foram realizadas pesquisas de palavras-chaves em contexto, usando a ferramenta Voyant Tools. Os resultados revelaram diferenças entre universidades públicas e privadas, com as primeiras enfatizando compromisso com a cidadania e o desenvolvimento social e sustentável, e as últimas conferindo maior destaque à formação profissional. Em média, a declaração de missão das universidades privadas é menor, mas possui maior diversidade lexical. Nas universidades públicas, há menos referência a valores corporativos, como o empreendedorismo. Esses resultados corroboram os de estudos realizados em outros países. Nas declarações de missão das universidades brasileiras, entretanto, há menos menções à internacionalização e à pesquisa, em comparação às estrangeiras. Resumo corpus coocorrências palavraschaves palavras chaves contexto Tools sustentável profissional média menor lexical corporativos empreendedorismo países entretanto pesquisa estrangeiras

Abstract: This study investigated whether institutional characteristics of Brazilian universities are reflected in their mission statements. Based on corpus linguistics techniques, the most frequent terms and their co-occurrences were identified, and keyword in context searches were conducted using Voyant Tools. Results have revealed differences between public and private universities, with the former emphasizing their commitment to citizenship and social and sustainable development, and the latter placing a greater emphasis on professional training. On average, private universities have shorter mission statements but higher lexical diversity. Public universities make fewer references to corporate values such as entrepreneurship. Such findings corroborate studies carried out in other countries. However, when comparing to foreign universities, Brazilian university mission statements mention internationalization and research less frequently. Abstract techniques cooccurrences co occurrences identified Tools development training average diversity entrepreneurship countries However frequently

Resumen: Este artículo investigó si las características institucionales de las universidades brasileñas se reflejan en sus declaraciones de misión. Utilizando técnicas de lingüística de corpus, se identificaron los términos más frecuentes, sus simultaneidades, y se realizaron búsquedas de palabras clave en contexto, utilizando la herramienta Voyant Tools. Los resultados revelaron diferencias entre universidades públicas y privadas, siendo las primeras las que enfatizan el compromiso con la ciudadanía y el desarrollo social y sostenible, mientras que las últimas hacen mayor énfasis en la formación profesional. En promedio, la declaración de misión de las universidades privadas es más breve, pero tiene una mayor diversidad léxica. En las universidades públicas, hay menos referencias a los valores corporativos como el espíritu empresarial. Estos resultados confirman los de estudios realizados en otros países. En las declaraciones de misión de las universidades brasileñas, sin embargo, hay menos menciones a la internacionalización y la investigación, en comparación con las universidades extranjeras. Resumen corpus frecuentes simultaneidades contexto Tools sostenible profesional promedio breve léxica empresarial países embargo investigación extranjeras

RESUMO JUSTIFICATIVA E OBJETIVOS: Mastectomia com linfadenectomia é uma cirurgia que causa dor moderada ou intensa no pós-operatório imediato. Muitos fármacos adjuvantes, seguros, que promovem boa analgesia e com poucos efeitos adversos têm sido pesquisados. A pregabalina e o sulfato de magnésio são fármacos que promovem analgesia com poucos efeitos adversos. O objetivo deste estudo foi avaliar o efeito analgésico da pregabalina e do sulfato de magnésio no pós-operatório de mastectomia com linfadenectomia axilar. MÉTODOS: Estudo randomizado e duplo-cego envolvendo 80 pacientes submetidas à mastectomia com linfadenectomia axilar sob anestesia geral. As pacientes foram divididas em quatro grupos: Controle (GC, não receberam o fármaco adjuvante proposto); Magnésio+Placebo (GM, receberam sulfato de magnésio durante a anestesia); Pregabalina+Magnésio (GP+M, receberam magnésio adicionado a pregabalina 150 mg antes e 12 h após a cirurgia); e Pregabalina+Placebo (GP, receberam a pregabalina). Todas as pacientes responderam o Self-Report Questionnaire 20 (SRQ-20) para rastrear possível transtorno mental e foram seguidas, monitorando o estado físico 1h, 12h e 24h após a cirurgia, através de anamnese, questionário de dor, consumo de opioides e presença de complicações e/ou eventos adversos como náusea, vômito e sonolência. A randomização foi realizada por meio de envelopes opacos e selados sem o conhecimento do anestesiologista (pesquisador) e do paciente. RESULTADOS: Foram randomizadas 20 pacientes para cada grupo, as quais foram analisadas ao fim do estudo. O número de pacientes apresentando dor ausente/leve no GP+M foi significantemente maior que nos GC, GM e GP após uma hora. Após 12 horas, GP+M e GP apresentaram maior número de pacientes com dor ausente/leve que GC e GM. Em 24 horas do pós-operatório, todos os pacientes de todos os grupos avaliados não apresentaram dor moderada/severa. Não houve diferença na frequência de pacientes apresentando náusea ou vômito, nem nos escores da avaliação do sono após a cirurgia nos quatro grupos. CONCLUSÃO: A associação de sulfato de magnésio e pregabalina causa boa analgesia de mastectomia com linfadenectomia axilar na primeira hora do pós-operatório. No entanto, o uso isolado do sulfato de magnésio não trouxe benefício para analgesia nestas pacientes, assim como a pregabalina sozinha se mostrou pouco efetiva na primeira hora de avaliação.

ABSTRACT BACKGROUND AND OBJECTIVES: Mastectomy with lymphadenectomy is a surgery associated with moderate to severe pain in the immediate postoperatory. Several safe adjuvant drugs that provide good analgesia with few adverse effects have been researched. Pregabalin and magnesium sulfate are drugs that promote analgesia with few adverse effects. The objective of the present study was to evaluate the analgesic effect of pregabalin and magnesium sulfate in the postoperatory of mastectomy with axillary lymphadenectomy. METHODS: Double-blinded, randomized study involving 80 patients submitted to mastectomy with axillary lymphadenectomy under general anesthesia. The patients were distributed into 4 groups: Control (CG, did not receive the proposed adjuvant drug); Magnesium+Placebo (MG, received magnesium sulfate during anesthesia); Pregabalin+Magnesium (P+MG, received magnesium added to pregabalin 150 mg before and 12 h after surgery); and Pregabalin+Placebo (PG, received pregabalin). All patients completed the Self-Report Questionnaire 20 (SRQ-20) to screen for possible mental disorders and had their physical status monitored at 1 h, 12 h, and 24 h after surgery, through anamnesis, pain questionnaire, opioid consumption, and presence of complications and/or adverse events such as nausea, vomiting, and sleepiness. Randomization was performed using sealed opaque envelopes without the knowledge of the anesthesiologist (researcher) and the patient. RESULTS: For each group, twenty patients were randomized, which were analyzed at the end of the study. The number of patients presenting absent/mild pain in P+MG was significantly higher than in CG, MG and PG after one hour. After 12 hours, P+MG and PG had more patients with absent/mild pain than CG and MG. At 24 hours postoperatively, all patients in all evaluated groups had no moderate/severe pain. There was no diference in the frequency of patients presenting nausea or vomiting, nor in the scores of the sleep evaluation after surgery in the four groups. CONCLUSION: The combination of magnesium sulfate and pregabalin provided satisfactory analgesia in the first hour after mastectomy with axillary lymphadenectomy. Nevertheless, magnesium sulfate isolated presented no analgesic beneft for the patients, and pregabalin isolated was only slightly effective at the first hour after surgery.

The growing process of a spinel-like oxide film can be obtained through different atmospheres; in this sense Air, O2, steam, and nitrogen atmospheres were used in different steps during the aging heat treatment at 490ºC of maraging 300 and 350 alloys. The oxidation layer produced under different atmospheres was chemically, microstructurally and mechanically characterized by means of advanced techniques. The results showed (in both alloys) a non-homogeneous mix oxide formed by magnetite, nickel and cobalt ferrites and MoO3 heterogeneously distributed along the oxide thickness. It was also founded TiO2 in the innermost areas and a particularly important quantify of hematite on the external surface. A nickel-rich austenite phase was produced at the interphase due to the combination of nickel stability and the preference of cobalt, molybdenum, and iron diffuses through the film as ions. The highest thickness values were found in the oxides produced in maraging 300 steels which could indicate greater susceptibility to oxidation comparing with grade 350 maraging steel. The oxide films produced in both maraging alloys using air atmosphere presents excellent adherence, and the results show the capability for being used for tribological applications under sliding contact tests.