Abstract This integrative review aims to identify the mental health care measures that were produced during the COVID-19 pandemic. This research was conducted on three databases (SciELO, PubMed, and LILACS) with the following descriptors in Portuguese, English, and Spanish: “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19” from 2020 to 2021. In total, 3,451 articles were found, 43 of which were analyzed. Most measures were digital, stemmed from public institutions, focused on the local perspective, and were integrated with the public health care system. This study discusses the models of care in mental health based on measures to cope with the COVID-19 pandemic. It also discusses the Brazilian health care system, reiterating its resilience. In conclusion, digital measures occurred most often. This study suggest the evaluation of the accessibility of this mental health care model for most vulnerable groups. Finally, this research reinforces the importance of the Brazilian health care system for public health and access to information to cope with the COVID-19 pandemic. COVID19 COVID 19 COVID-1 pandemic SciELO, SciELO (SciELO PubMed LILACS Portuguese English Spanish SAÚDE MENTAL SALUD HEALTH “COVID-19 202 2021 total 3451 3 451 3,45 found 4 analyzed institutions perspective resilience conclusion often groups Finally COVID1 1 COVID- “COVID-1 20 345 45 3,4 “COVID- 2 34 3, “COVID

Resumo A presente revisão integrativa tem por objetivo identificar os arranjos de cuidado em saúde mental que foram implementados no enfrentamento à pandemia de COVID-19. Realizou-se busca em três bases de dados (SciELO, PubMed e LILACS), em português, inglês e espanhol, com os descritores “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19”, no período de 2020 a 2021. Foram encontrados 3.451 artigos, sendo 43 selecionados para análise. Em relação ao cuidado em saúde mental, os principais arranjos identificados foram os digitais, de natureza pública, desenvolvidos na esfera municipal e com integração com a rede de saúde. Os modelos de cuidado em saúde mental para o enfrentamento da pandemia são discutidos a partir dos tipos de arranjo produzidos nesse contexto sanitário emergencial e crítico. Apresenta-se, ainda, um recorte da realidade encontrada no Sistema Único de Saúde (SUS), reiterando sua resiliência. Concluiu-se que os arranjos digitais foram os mais usados e que há necessidade de investigar a acessibilidade deste modelo para populações com maior vulnerabilidade social. Reafirma-se a importância do SUS para o enfrentamento da COVID-19 e no acesso a informações de saúde. COVID19. COVID19 COVID 19. 19 Realizouse Realizou se SciELO, SciELO (SciELO LILACS, LILACS , LILACS) português espanhol SAÚDE MENTAL SALUD HEALTH COVID19, “COVID-19” 202 2021 3451 3 451 3.45 artigos 4 análise pública crítico Apresentase, Apresentase Apresenta se, Apresenta-se ainda SUS, (SUS) resiliência Concluiuse Concluiu social Reafirmase Reafirma COVID-1 COVID1 1 “COVID-19 20 345 45 3.4 (SUS COVID- “COVID-1 2 34 3. “COVID- “COVID

Abstract Primary Health Care (PHC) proved to be an important part of the prevention, control and treatment measures against COVID-19, a situation in which it was challenged to keep up its provision of regular services as well. This article identifies the main arrangements made to provide PHC care in the context of the COVID-19 pandemic. An integrative literature review of articles found in PubMed, SciELO and LILACS databases was performed using the descriptors “Primary Health Care” and “COVID-19”. Findings were analyzed considering three questions: Information and Communication Technologies (ICT), Organizations of Work Processes and Non-COVID Chronic Diseases. The use of different forms of ICT to provide PHC is highlighted regarding patients with respiratory symptoms and chronic patients. Changes in team composition, service flows, physical spaces and working hours were also introduced. Although strategies aimed at monitoring chronic patients and at remote care may have helped minimize deterioration of their health, the decrease in the number of visits performed during this period could have resulted in an increased demand for PHC in post-pandemic years. (PHC prevention COVID19, COVID19 COVID 19, 19 well COVID-1 pandemic PubMed COVID19. . “COVID-19” questions ICT, , (ICT) NonCOVID Non Diseases composition flows introduced health postpandemic post years COVID1 1 COVID- “COVID-19 (ICT “COVID-1 “COVID- “COVID

Resumo A Atenção Primária à Saúde (APS) demonstrou ser parte importante das medidas de prevenção, controle e tratamento do COVID-19, ao mesmo tempo em que foi desafiada a manter a oferta dos serviços regulares. O objetivo deste artigo é identificar os principais arranjos desenvolvidos para ofertar cuidados na APS na pandemia do COVID-19. A revisão integrativa foi realizada nas bases de dados PubMed, SciELO e LILACS por meio dos descritores “Atenção Primária à Saúde” e “COVID-19”. Os resultados foram analisados por meio de três questões: Tecnologias de Informação e Comunicação (TIC), Organizações dos Processos de Trabalho e Doenças Crônicas Não-COVID. Ganha grande destaque o uso das TIC no cuidado ofertado na APS, tanto para pacientes com sintomas respiratórios quanto para pacientes crônicos. Alterações na composição das equipes, fluxos de atendimento, espaços físicos e horários de atendimento também foram implantadas. Ainda que estratégias que visaram o monitoramento dos pacientes crônicos e o atendimento remoto podem ter contribuído para minimizar os agravos à saúde desses usuários, a diminuição dos atendimentos realizados neste período poderá resultar em uma grande demanda para a APS nos anos pós-pandemia. (APS prevenção COVID19, COVID19 COVID 19, 19 COVID-19 regulares COVID19. 19. PubMed . “COVID-19” questões TIC, , (TIC) NãoCOVID. NãoCOVID Não COVID. Não-COVID equipes implantadas usuários póspandemia. póspandemia pós pandemia. pós-pandemia COVID1 1 COVID-1 “COVID-19 (TIC COVID- “COVID-1 “COVID- “COVID

Resumo A Atenção Primária à Saúde (APS) demonstrou ser parte importante das medidas de prevenção, controle e tratamento do COVID-19, ao mesmo tempo em que foi desafiada a manter a oferta dos serviços regulares. O objetivo deste artigo é identificar os principais arranjos desenvolvidos para ofertar cuidados na APS na pandemia do COVID-19. A revisão integrativa foi realizada nas bases de dados PubMed, SciELO e LILACS por meio dos descritores “Atenção Primária à Saúde” e “COVID-19”. Os resultados foram analisados por meio de três questões: Tecnologias de Informação e Comunicação (TIC), Organizações dos Processos de Trabalho e Doenças Crônicas Não-COVID. Ganha grande destaque o uso das TIC no cuidado ofertado na APS, tanto para pacientes com sintomas respiratórios quanto para pacientes crônicos. Alterações na composição das equipes, fluxos de atendimento, espaços físicos e horários de atendimento também foram implantadas. Ainda que estratégias que visaram o monitoramento dos pacientes crônicos e o atendimento remoto podem ter contribuído para minimizar os agravos à saúde desses usuários, a diminuição dos atendimentos realizados neste período poderá resultar em uma grande demanda para a APS nos anos pós-pandemia.

Abstract Primary Health Care (PHC) proved to be an important part of the prevention, control and treatment measures against COVID-19, a situation in which it was challenged to keep up its provision of regular services as well. This article identifies the main arrangements made to provide PHC care in the context of the COVID-19 pandemic. An integrative literature review of articles found in PubMed, SciELO and LILACS databases was performed using the descriptors “Primary Health Care” and “COVID-19”. Findings were analyzed considering three questions: Information and Communication Technologies (ICT), Organizations of Work Processes and Non-COVID Chronic Diseases. The use of different forms of ICT to provide PHC is highlighted regarding patients with respiratory symptoms and chronic patients. Changes in team composition, service flows, physical spaces and working hours were also introduced. Although strategies aimed at monitoring chronic patients and at remote care may have helped minimize deterioration of their health, the decrease in the number of visits performed during this period could have resulted in an increased demand for PHC in post-pandemic years.

Abstract Immigrant children who arrive in the city of São Paulo face numerous challenges, especially regarding the realization of the right to school education. Given this scenario, the problem that arises is: what projects and public policies guarantee that they access the public education system? To answer this question, an approach was taken to laws that consecrate the right to school education. Then, a series of policies and projects developed in the municipality were presented, ranging from the creation of specialized bodies to the adoption of practices that reduce school dropout and discrimination, raise awareness among education professionals and promote interculturality. In the end, it was proven that these projects and policies guarantee the access and permanence of immigrant children in the public education system. The study methodology used was based on qualitative research using the deductive method. There was also descriptive qualitative research. For the analytical and interpretative reading, the hermeneutics of human rights was used as a reference.

Resumo As crianças3 imigrantes que aportam na cidade de São Paulo enfrentam inúmeros desafios, sobretudo quanto à efetivação do direito à educação escolar. Diante desse cenário, o problema que se coloca é: quais projetos e políticas públicas concorrem para que elas acessem o sistema público de ensino? Para responder a esse questionamento, foram abordadas as normativas que consagram o direito à educação escolar. Em seguida, foi apresentada uma série de políticas e projetos desenvolvidos no município, que vão desde a criação de órgãos especializados até a adoção de práticas que reduzem a evasão escolar e a discriminação, conscientizam os profissionais da educação e promovem a interculturalidade. Ao final, ficou comprovado que esses projetos e políticas garantem o acesso e a permanência das crianças imigrantes no sistema público de ensino. A metodologia de estudo utilizada baseou-se na pesquisa qualitativa pelo método dedutivo. Também houve pesquisa qualitativa descritiva. Para a leitura analítica e interpretativa, utilizou-se como referência a hermenêutica dos direitos humanos.

Resumo A presente revisão integrativa tem por objetivo identificar os arranjos de cuidado em saúde mental que foram implementados no enfrentamento à pandemia de COVID-19. Realizou-se busca em três bases de dados (SciELO, PubMed e LILACS), em português, inglês e espanhol, com os descritores “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19”, no período de 2020 a 2021. Foram encontrados 3.451 artigos, sendo 43 selecionados para análise. Em relação ao cuidado em saúde mental, os principais arranjos identificados foram os digitais, de natureza pública, desenvolvidos na esfera municipal e com integração com a rede de saúde. Os modelos de cuidado em saúde mental para o enfrentamento da pandemia são discutidos a partir dos tipos de arranjo produzidos nesse contexto sanitário emergencial e crítico. Apresenta-se, ainda, um recorte da realidade encontrada no Sistema Único de Saúde (SUS), reiterando sua resiliência. Concluiu-se que os arranjos digitais foram os mais usados e que há necessidade de investigar a acessibilidade deste modelo para populações com maior vulnerabilidade social. Reafirma-se a importância do SUS para o enfrentamento da COVID-19 e no acesso a informações de saúde.

Abstract This integrative review aims to identify the mental health care measures that were produced during the COVID-19 pandemic. This research was conducted on three databases (SciELO, PubMed, and LILACS) with the following descriptors in Portuguese, English, and Spanish: “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19” from 2020 to 2021. In total, 3,451 articles were found, 43 of which were analyzed. Most measures were digital, stemmed from public institutions, focused on the local perspective, and were integrated with the public health care system. This study discusses the models of care in mental health based on measures to cope with the COVID-19 pandemic. It also discusses the Brazilian health care system, reiterating its resilience. In conclusion, digital measures occurred most often. This study suggest the evaluation of the accessibility of this mental health care model for most vulnerable groups. Finally, this research reinforces the importance of the Brazilian health care system for public health and access to information to cope with the COVID-19 pandemic.

Resumo A situação de vulnerabilidade ambiental de algumas populações urbanas tende a ser associada a uma espécie de ignorância ou indiferença dessas populações sobre o risco geológico dos seus territórios. Isso, contudo, ignora que a ocupação do solo urbano não é simples fruto de decisões individuais, mas, sim, da dinâmica complexa entre renda, classe social, racialidade, movimentos sociais e arranjos político-institucionais. A partir dessa compreensão, apresenta-se uma reflexão acerca da distribuição espacial do risco e das vulnerabilidades ambiental e social na Região Metropolitana de Belo Horizonte (RMBH). A análise baseia-se no cruzamento de mapas de riscos ambientais e de zoneamento dos três municípios componentes da área de contribuição da bacia hidrográfica do Arrudas, unidade de análise selecionada dentro da RMBH. territórios Isso contudo individuais mas sim renda racialidade políticoinstitucionais. políticoinstitucionais político institucionais. institucionais político-institucionais compreensão apresentase apresenta se RMBH . (RMBH) baseiase baseia Arrudas (RMBH

Abstract The situation of environmental vulnerability of some urban populations tends to be associated with their ignorance or indifference regarding the geological risk of their territories. However, this does not take into account that urban land occupation does not result simply from individual decisions, but from a complex dynamics between income, social class, race, social movements, and political-institutional arrangements. Based on this understanding, this study presents a reflection on the spatial distribution of risk and environmental and social vulnerabilities in the Metropolitan Region of Belo Horizonte (MRBH). The analysis is based on the comparison between environmental risk maps and zoning maps of the three municipalities that make up the contributing area of the Arrudas watershed, the unit of analysis selected within the MRBH. territories However decisions income class race movements politicalinstitutional political institutional arrangements understanding MRBH . (MRBH) watershed (MRBH

RESUMEN: Este artículo presenta una revisión de la literatura sobre los relatos acerca de las personas con autismo en las investigaciones realizadas en los campos de Educación, Psicología, Medicina y Enfermería. Se recogieron 22 artículos de la base de datos SciELO, entre 2008 y 2021, utilizando las palabras clave autismo y entrevistas. Los datos se analizaron mediante la técnica de Análisis de Contenido (BARDIN, 2016), con la ayuda del software ATLAS.ti. Las categorías planteadas, diagnóstico y salud; educación; y relaciones familiares, fueron discutidas desde las perspectivas teóricas y metodológicas de Vygotsky (2003) y Bronfenbrenner (1996). Este análisis permitió relacionar las cuestiones personales con las sociales, a partir de las relaciones socio-históricas y bioecológicas que envuelven la vida de los sujetos con autismo. Los resultados señalan la interferencia entre la insuficiente oferta de servicios y políticas de apoyo social y el desarrollo de estas personas; la importancia de la escuela y la deficiente formación docente; y las repercusiones de este desarrollo en las rutinas familiares, especialmente en la vida de la figura materna. RESUMEN Educación Psicología Enfermería 2 SciELO 200 2021 entrevistas BARDIN, BARDIN (BARDIN 2016, 2016 , 2016) ATLASti ATLAS ti ATLAS.ti planteadas salud educación familiares 2003 (2003 1996. 1996 . (1996) sociales sociohistóricas socio históricas docente materna 20 202 201 (200 199 (1996 (20 19 (199 (2 1 (19 ( (1

RESUMO: Este artigo apresenta uma revisão da literatura sobre relatos acerca de pessoas com autismo em pesquisas realizadas nos campos da Educação, Psicologia, Medicina e Enfermagem. Foram coletados 22 artigos na base de dados SciELO, entre os anos de 2008 e 2021, a partir das palavras-chave autismo e entrevistas. Os dados foram analisados pela técnica da Análise de Conteúdo (BARDIN, 2016), com o auxílio do software ATLAS.ti. As categorias levantadas - diagnóstico e saúde; educação; e relações familiares - foram discutidas a partir das perspectivas teórico-metodológicas de Vygotsky (2003) e Bronfenbrenner (1996). Tal análise permitiu relacionar as questões pessoais com as sociais, tomando por base as relações socio-históricas e bioecológicas que envolvem a vida dos sujeitos com autismo. Os resultados apontam para a interferência entre a insuficiência de oferta de serviços e políticas de suporte social e o desenvolvimento dessas pessoas; a importância da escola e a deficitária formação docente; e as repercussões desse desenvolvimento nas rotinas familiares, sobretudo na vida da figura materna. RESUMO Educação Psicologia Enfermagem 2 SciELO 200 2021 palavraschave palavras chave entrevistas BARDIN, BARDIN (BARDIN 2016, 2016 , 2016) ATLASti ATLAS ti ATLAS.ti saúde educação teóricometodológicas teórico metodológicas 2003 (2003 1996. 1996 . (1996) sociais sociohistóricas socio históricas docente materna 20 202 201 (200 199 (1996 (20 19 (199 (2 1 (19 ( (1

ABSTRACT: This article presents a literature review on reports about people with autism in research carried out in the areas of Education, Psychology, Medicine, and Nursing. We collected twenty-two articles in the SciELO database between 2008 and 2021, using the keywords autism and interviews. We analyzed the data using the Content Analysis technique (BARDIN, 2016) with the help of ATLAS.ti software. We discussed the categories raised, diagnosis and health; education; and family relationships from the theoretical-methodological perspectives of Vygotsky (2003) and Bronfenbrenner (1996). Such an analysis made it possible to relate personal and social issues based on the socio-historical and bioecological relationships that involve the lives of subjects with autism. The results show the interference between the insufficient supply of services and social support policies and these people's development; the importance of school and the inadequate teacher training; and the repercussions of this development in family routines, especially in the life of the mother figure. ABSTRACT Education Psychology Medicine Nursing twentytwo twenty two 200 2021 interviews BARDIN, BARDIN (BARDIN 2016 ATLASti ATLAS ti software raised health education theoreticalmethodological theoretical methodological 2003 (2003 1996. 1996 . (1996) sociohistorical socio historical peoples s training routines figure 20 202 201 (200 199 (1996 2 (20 19 (199 (2 1 (19 ( (1

This article presents a literature review on reports about people with autism in research carried out in the Education, Psychology, Medicine and Nursing’s areas. Twenty two articles were collected in the SciELO database, between the years 2008 and 2021, using the keywords autism and interviews. Data were analyzed using the Content Analysis technique (BARDIN, 2016), with the help of ATLAS.ti software. The categories raised, diagnosis and health; education; and family relationships, were discussed from the theoretical-methodological perspectives of Vygotsky (2003) and Bronfenbrenner (1996). Such analysis made it possible to relate personal and social issues, based on the socio-historical and bioecological relationships that involve the lives of subjects with autism. The results show the interference between the insufficient supply of services and social support policies and the development of these people; the importance of the school and the deficient teacher training; and the repercussions of this development in family routines, especially in the life of the mother figure.

Este artículo presenta una revisión bibliográfica sobre los relatos acerca de las personas con autismo en las investigaciones realizadas en los campos de Educación, Psicología, Medicina y Enfermería. Se recogieron 22 artículos de la base de datos SciELO, entre 2008 y 2021, utilizando las palabras clave autismo y entrevistas. Los datos se analizaron mediante la técnica de Análisis de Contenido (BARDIN, 2016), con la ayuda del software ATLAS.ti. Las categorías planteadas, diagnóstico y salud; educación; y relaciones familiares, fueron discutidas desde las perspectivas teóricas y metodológicas de Vygotsky (2003) y Bronfenbrenner (1996). Este análisis permitió relacionar las cuestiones personales con las sociales, a partir de las relaciones socio-históricas y bio-ecológicas que envuelven la vida de los sujetos con autismo. Los resultados señalan la interferencia entre la insuficiente oferta de servicios y políticas de apoyo social y el desarrollo de estas personas; la importancia de la escuela y la deficiente formación del profesorado; y las repercusiones de este desarrollo en las rutinas familiares, especialmente en la vida de la figura materna.

Este artigo apresenta uma revisão da literatura sobre relatos acerca de pessoas com autismo em pesquisas realizadas nos campos da Educação, Psicologia, Medicina e Enfermagem. Foram coletados 22 artigos na base de dados SciELO, entre os anos de 2008 e 2021, a partir das palavras-chave autismo e entrevistas. Os dados foram analisados pela técnica da Análise de Conteúdo (BARDIN, 2016), com o auxílio do software ATLAS.ti. As categorias levantadas, diagnóstico e saúde; educação; e relações familiares, foram discutidas a partir das perspectivas teórico-metodológicas de Vygotsky (2003) e Bronfenbrenner (1996). Tal análise permitiu relacionar as questões pessoais com as sociais, tomando por base as relações sóciohistóricas e bioecológicas que envolvem a vida dos sujeitos com autismo. Os resultados apontam para a interferência entre a insuficiência de oferta de serviços e políticas de suporte social e o desenvolvimento destas pessoas; a importância da escola e a deficitária formação docente; e as repercussões deste desenvolvimento nas rotinas familiares, sobretudo na vida da figura materna.

Abstract To produce pitaya (Hylocereus spp.), it is essential that pollination occur, either artificially or by pollinating agents. This study evaluated the viability of self-pollination, cross-pollination, and natural pollination, as well as pollen viability, stigma receptivity and ideal pollination window in pitaya flowers (Hylocereus spp.). An experiment was conducted with a randomized block design consisting of four treatments: T1: manual self-pollination; T2: nocturnal open pollination; T3: diurnal open pollination; and T4: manual cross-pollination - red-fleshed pitaya [ Hylocereus polyrhizus] pollen placed on white-fleshed pitaya [ Hylocereus undatus] stigma. The experiment had four replicates, with two plants per replicate (two flowers per plant), totaling 16 flowers per treatment. The analyzed variables were fruit weight, length, diameter, titratable acidity, pH, soluble solids, and SS/TA ratio; the germination percentage of pollen grains; and the receptivity of stigmas. Artificial pollination (self- and cross-pollination) of white-fleshed pitaya (Hylocereus undatus) is viable, resulting in larger fruits than natural pollination, with cross-pollination being the most recommended. Throughout the floral opening period, the pitaya flower (Hylocereus spp.) has receptive stigma capable of receiving pollen. The flowers exhibit the highest pollen germination rate at 7 p.m, which is the ideal pollination window for pitaya.

Abstract Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a systematic review of PFP cases temporally related to COVID-19 using PubMed, Embase, and Cochrane Library databases on August 30, 2021, using a rapid review methodology. The two patients experienced PFP 102 and 110 days after COVID-19 symptom onset. SARS-CoV-2 RNA was detected in nasal samples through reverse-transcription real-time polymerase chain reaction (RT-qPCR) testing. Anosmia was the only other neurological manifestation. PFP was treated with steroids in both cases, with complete subsequent recovery. In the rapid review, we identified 764 articles and included 43 studies. From those, 128 patients with PFP were analyzed, of whom 42.1% (54/128) were male, 39.06% (50/128) female, and in 23 cases the gender was not reported. The age range was 18 to 59 (54.68%). The median time between COVID-19 and PFP was three days (ranging from the first symptom of COVID-19 to 40 days after the acute phase of infection). Late PFP associated with COVID-19 presents mild symptoms and improves with time, with no identified predictors. Late PFP should be added to the spectrum of neurological manifestations associated with the long-term effects of SARS-CoV-2 infection as a post COVID-19 condition.

RESUMO Este estudo comparou a capacidade de modelagem dos sistemas reciprocante de lima única (WaveOne Gold) e rotatórios com múltiplas limas (Mtwo) em caninos ovais inferiores, usando microtomografia computadorizada (micro-CT). Trinta caninos inferiores foram escaneados por micro-CT e divididos em dois grupos (n = 15) de acordo com o sistema usado durante o preparo do canal radicular: WaveOne Gold (WOG) e Mtwo. Os dentes foram reeescaneados e a porcentagem de área do canal não preparada, transporte apical e capacidade de centralização foram analisados. Os dados foram avaliados pelos testes de Kruskal Wallis e Mann-Whitney (p<0,05). Nenhuma diferença foi encontrada na porcentagem de área não preparada entre os grupos em todo o canal radicular e no terço apical e na capacidade de centralização (p>0,05). O sistema WOG promoveu menor transporte do canal do que o sistema Mtwo na região de 5mm aquém do ápice (p<0,05). Os sistemas WOG e Mtwo apresentaram capacidade de modelagem e capacidade de centralização semelhantes em canais ovais. No entanto, WOG promoveu menor transporte do que Mtwo a 5 mm do ápice.

ABSTRACT This study compared the shaping ability of single-file reciprocating (WaveOne Gold) and multifile rotary (Mtwo) systems on mandibular oval-shaped canine root canals, using microcomputed tomography (micro-CT). Thirty mandibular canines were scanned by micro-CT and assigned to one of two groups (n=15) according to the system used for root canal preparation: WaveOne Gold or Mtwo. After preparation, the teeth were rescanned, and the percentage of untouched canal area, apical transportation and centering ability were analyzed. The data was evaluated using Kruskal and Mann- Whitney tests (p<0.05). No difference was found in percentage of unprepared canal area between groups in the entire root canal or the apical third, or in centering ability (p>0.05). WaveOne gold had less canal transportation than MTwo at the 5 mm section (p<0.05). WOG and Mtwo systems presented similar shaping ability and centering ability in oval-shaped canals. However, WOG presented less transportation than Mtwo at 5 mm from the apex.

Essential oils (EOs) of the leaves of three Eugenia punicifolia specimens from two different Reservation Parks, namely Parque Nacional das Nascentes do Rio Parnaíba (EpNRP-I and EpNRP-II) and Parque Nacional da Chapada das Mesas (EpCM), in the state of Maranhão, Brazil, were extracted by hydrodistillation and investigated by gas chromatography coupled to mass spectrometry. Principal component and hierarchical cluster analyses indicated differences between the samples. Antiproliferative EOs activity was determined for U-251 (glioblastoma), MCF-7 (breast adenocarcinoma), NCI/ADR-RES (multidrug-resistant ovarian adenocarcinoma), OVCAR-3 (ovarian adenocarcinoma), HT-29 (colorectal adenocarcinoma), and HaCaT (non-tumor keratinocyte) cell lines applying the colorimetric method using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) to determine the GI50 (50% growth inhibition) concentration. The extraction yields of the analyzed EOs were 0.58, 1.42 and 0.84%. The main constituents identified in two samples were α-pinene (49.75%), 1,8-cineole (13.77%) and (-terpineol (7.32%), and in the third sample, germacrene B (16.25%), (E)-caryophyllene (13.21%) and β-pinene (12.81%). The main GI50 results for sample EpNRP-I were noted for the U-251 (2.13 µg mL−1) and MCF-7 (6.72 µg mL−1) tumor lines. For the non-tumoral line HaCaT, the calculated GI50 was higher than the positive control comprising doxorubicin hydrochloride (13.35 µg mL−1). In addition, a flow cytometry analysis revealed that this same sample arrests the cell cycle of the MCF-7 line in the second interphase stage.

The death of professor Rolf Huisgen (1920-2020) was announced on March 26th 2020, in the midst of the COVID-19 pandemic. Professor Huisgen was professor emeritus at the University of Munich in Germany, and studied in detail the mechanism of the 1,3-dipolar cycloaddition reaction, significantly expanding its scope. Even though he did not discover this reaction, it was through his studies that it became important in organic synthesis. Indeed, in honor of his work, the reaction became known as Huisgen’s cycloaddition and it has been consolidated as a useful method for the preparation of five-membered heterocyclic compounds. Considering these facts, in this review we provide an overview on the applications of 1,3-dipolar cycloaddition reactions, starting with the seminal examples in the field and further discussing the most recent applications.

Abstract: Accumulated hard tissue debris (AHTD) in root canal irregularities may negatively impact adequate root canal disinfection. In light of this, the efficacy of passive ultrasonic irrigation (PUI) to reduce AHTD has been largely studied in in vitro studies, which have adopted different analytic methods of varying accuracy to determine the extent of AHTD more correctly. Therefore, the aim of this study was to compare how well PUI and non-activated irrigation (NAI) systems perform in reducing AHTD during final irrigation protocols, based exclusively on studies whose analyses used microCT scanning. A systematic search of the studies published up to April 2020 was performed using MeSH terms and free terms, in the following databases: PubMed, Scopus, Web of Science, BVS (Lilacs and BBO) and Embase. The inclusion criteria consisted of laboratory studies that evaluated the amount of AHTD, and compared PUI with NAI protocols using microCT analysis. The risk of bias in the selected studies was assessed critically by two reviewers. A meta-analysis was performed using the RevMan software program (P<0.05), and included studies providing the standardized mean difference (SMD), using a fixed effect model, and adopting a confidence interval of 95%. In all, 3495 studies were identified, three of which met the inclusion criteria. All three were considered as having a low risk of bias. The meta-analysis comparing the ability of PUI and NAI protocols to remove hard tissue debris showed a higher percentage of AHTD reduction (P<0.01) for PUI, with a confidence interval of 1.41 [0.79, 2.02]. The heterogeneity among the studies was 82% (I2). Considering the limitations of the present study, this systematic review and meta-analysis showed that PUI was more effective than NAI in removing hard tissue debris, based exclusively on studies that used microCT scanning to provide a more precise analysis of the two techniques used. The findings presented in the present study reinforce the concept that PUI can increase residue removal and improve the cleanliness of the root canal in endodontic treatments.

Resumo Retinopatia externa oculta zonal aguda (AZOOR) foi descrita pela primeira vez por Gass em 1993 como uma síndrome com perda rápida de uma ou mais zonas extensas dos segmentos externos da retina. Paciente masculino, 35 anos, portador de doença de Crohn, queixando-se de dor ocular eventual e nictalopia em olho direito desde infância. Em uso regular de azatioprina e mesalazina. melhor acuidade visual 20/20 AO. À fundoscopia, lesões hiperpigmentadas em arcada temporal inferior de olho direito, em treliça, acompanhando vasculatura local. Após exclusão de diagnósticos diferenciais chegou-se ao diagnóstico de Azoor. Azoor é uma síndrome idiopática caracterizada por um quadro agudo início de fotopsia, escotoma ou ambos e é tipicamente associado a uma perda persistente de função visual que envolve uma ou mais zonas da retina externa. Apesar dos sintomas clássicos de fotopsia, o paciente em questão teve uma apresentação clínica atípica. Descrevemos um caso ocorrido em indivíduo do sexo masculino em região periférica apresentando afinamento coroidiano e com doença autoimune associada. Dessa forma, acreditamos que é necessária maior investigação para verificar a etiologia da alteração coroideana e da associação com a doença específica.

Abstract Acute zonal occult external retinopathy (AZOOR) was first described by Gass in 1993 as a syndrome with rapid loss of one or more large areas of the external retinal segments. Male, 35 years, with Crohn's disease complaining of occasional eye pain and right eye nictalopia since childhood. In regular use of azathioprine and mesalazine. better visual acuity 20/20 OU. At fundoscopy, hyperpigmented lesions in the right temporal arcade of the right eye, in trellis, accompanying local vasculature. After exclusion of differential diagnoses, Azoor's diagnosis was reached. Azoor is an idiopathic syndrome characterized by an acute onset of photopsy, scotoma or both and is typically associated with a persistent loss of visual function involving one or more areas of the external retina. Despite classic photopsy symptoms, the patient in question had an atypical clinical presentation. We describe a case of a peripheral male with choroidal thinning and associated autoimmune disease. Thus, we believe that further investigation is necessary to verify the etiology of choroidal alteration and its association with the specific disease.