Abstract Cassava-torrado-like virus (CsTLV) is a bipartite single-stranded RNA virus belonging to the family Secoviridae. The virus has been reported in Brazil and Colombia, and is usually found in mixed infections, and in plants affected by Cassava Frogskin Disease (CFSD), an endemic cassava disease in the Americas. Genome analysis of CsTLV identifies a gene in RNA2 implicated in pathogen movement in other torradoviruses. This gene (RNA2-ORF1) and another one no related to virus movement (Maf/Ham1) were amplified by PCR and cloned into constructs under the 35S promoter of cauliflower mosaic virus (CaMV), which then were transfered to agrobacterium binary vectors. When agro-infiltrated in Nicotiana benthamiana plants, only RNA2-ORF1 had a positive effect on the mechanical inoculation of cassava virus X (CsVX), a potexvirus that has a low rate of mechanical infection in N. benthamiana. Efficiency of CsVX mechanical transmission was measured by the number of infected plants, presence of symptoms, and titers of CsVX as measured by ELISA, two weeks after infection. On average, CsVX could infect 2.3 times more plants when these were previously agro-infiltrated with A. tumefaciens binary vector encoding CsTLV RNA2-ORF1. We conclude that the novel secovirid CsTLV associated with leaf spot symptoms in cassava, encodes a gene that could enhance other viral infections in N. benthamiana. Further studies are required to elucidate this effect and its role in mixed infections, often observed in cassava plants affected by CFSD.

ABSTRACT Introduction: Cuba is going through a changing context that impacts the family sphere. This requires new perspectives towards families from science and politics. The place that adolescents and young people occupy in the sphere of family and couples, and their modes of interaction, contributes to the resizing of youth policies. Methods: A mixed approach was used and the information resulting from the applied techniques was triangulated. The sample was representative by age groups and areas of residence. Gender and rights approaches were considered. Results and Discussion: Scientific information on adolescents and young people in the referred areas has been systematized. Modes of interaction of these populations were characterized according to affective relationships, information/orientation and participation in these spaces. The orientation program “Learning to live as a family and as a couple” was designed and implemented from the methodology of popular education. Conclusions: Problems related to these populations are studied, without singling out -sufficiently- their dynamics. This limits the possibilities of understanding interaction patterns that occur in these contexts and leads to the violation of some rights. Featuring adolescents and young people interactions on the family and the couple sphere was essential in order to develop some guidance actions for bringing into focus their most meaningful needs.

RESUMEN Introducción: Cuba transita por un contexto cambiante que impacta el escenario familiar. Ello exige nuevas miradas hacia las familias desde las Ciencias y la política. El lugar que ocupan adolescentes y jóvenes en los ámbitos de familia y pareja, y sus modos de interacción, contribuye al redimensionamiento de políticas de juventud. Métodos: Se utilizó un enfoque mixto y se realizó la triangulación de la información resultante de las técnicas aplicadas. La muestra fue representativa por grupos etarios y zonas de residencia. Se consideraron los enfoques de género y derechos. Resultados y Discusión: Sistematizada información científica sobre adolescentes y jóvenes en los ámbitos referidos. Fueron caracterizados modos de interacción de estas poblaciones atendiendo a relaciones afectivas, información/orientación y participación en estos espacios. Diseñado e implementado el programa de orientación “Aprendiendo a vivir en familia y pareja”, desde la metodología de la educación popular. Conclusiones, el estudio de problemáticas relacionadas con estas poblaciones, sin particularizar -suficientemente- en sus dinámicas, limita las posibilidades de comprender pautas de interacción que acontecen en estos contextos y propician la vulneración de algunos derechos. Caracterizar las interacciones de adolescentes y jóvenes en los escenarios de familia y pareja fue esencial para la acción de orientación, enfocada en sus necesidades más sentidas.

ABSTRACT The connotation of the school space as one of the areas recognized as a guarantor of human rights is a vital idea and is closely related to the act of educating in ethical and moral values such as respect, tolerance, the eradication of violence, participation and social inclusion. For its part, violence, as a complex and multifactorial social phenomenon, is on the rise every day and generates unsafe and unharmonious environments, especially for infants, adolescents and young people. By following this logic and assuming these notions as guiding axes, this article deals with education as a universal human right, which, despite legal guarantees, is violated and to which millions of people in the world do not have access. Likewise, it approaches the manifestations of violence that occur in educational contexts and how, from its conception, human rights education could be a tool in its prevention, as it provides the subjects with modeling norms of their system of relationships, based on dialogue and respect for the other.

RESUMEN La connotación del espacio escolar como uno de los ámbitos reconocidos como garante de los derechos humanos es una idea vital y guarda estrecha relación con el acto de educar en valores éticos y morales como el respeto, la tolerancia, la erradicación de la violencia, la participación y la inclusión social. Por su parte, la violencia, en tanto fenómeno social, complejo y multifactorial, cobra auge cada día y genera ambientes no seguros ni armónicos, sobre todo para infantes, adolescentes y jóvenes. Al seguir esta lógica y asumir como ejes conductores dichas nociones, el presente artículo aborda acerca de la educación como derecho humano universal, el cual, pese a las garantías jurídicas, resulta vulnerado y al que no acceden millones de personas en el mundo. Asimismo, se acerca a las manifestaciones de violencias que ocurren en los contextos educativos y a cómo, desde su concepción, la educación en derechos humanos pudiera ser una herramienta en su prevención, en tanto dota a los sujetos de normas modeladoras de su sistema de relaciones, sobre la base del diálogo y el respeto al otro.

Background: Depression is a highly prevalent disease in Chilean adults. Aim: To identify sociodemographic, biomedical, and psychosocial factors related with depression in a representative sample of the Chilean adult population. Material and Methods: Analysis of data from the National Health Survey 2016-2017 which included 5,291 participants aged > 15 years. Depression was assessed using the Composite International Diagnostic Interview (CIDI-SF). Association between sociodemographic data, health and psychosocial variables and depression was analyzed using Poisson regression with robust error. Results: The probability of depression was higher in women than in men (prevalence ratio (PR) = 2.13 [95% confidence intervals (CI): 1.65, 2.75]). In both genders, the probability was higher in people with frailty (women: PR = 10.0 [95% CI: 1.86, 18.1] and men: PR = 3.38 [95% CI: 2.72; 4.20]), severe chronic pain (women: PR = 2.84 [95% CI: 1.93, 4.18 and men: PR = 6.41 [95% CI: 3.59, 9.40]), presence of two or more diseases (women: PR = 4.15 [95% CI: 2.78, 6.20 and men: PR = 2.60 [95% CI: 1.39, 3.81]), perception of permanent stress (women: PR = 11.0 [95% CI: 6.13, 16.0], men: PR = 21.0 [95% CI: 10.2, 31.7]), financial stress (women: PR = 2.57 [95% CI: 1.87, 3.27] men: PR = 4.27 [95% CI: 2.48, 6.06] and poor or very poor perception of health (women: PR = 5.02 [95% CI: 1.92, 8.12], men: 2.09 [95% CI: 0.49, 3.69]). In men, the probability of depression was higher for widowers than married man (PR = 5.58 [95% CI: 2.5, 8.25]), presence of goiter (PR = 4.03 [95% CI: 1.99, 6.07]) and low social support (PR = 1.95 [95% CI: 1.18; 2.72]). Conclusions: The factors associated with a higher probability of depression are diverse in nature. Among these being women, frailty, chronic pain, multimorbidity and high perception of stress are important factors.

ABSTRACT Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMAIR, leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression. Results: The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin for each copy of the minor allele (95% CI: 0.12, 2.87, p < 0.05). This association remained significant after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95% CI: 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI was also significantly associated with polymorphic genotypes in SLC16A11, independent of socio-demographic variables. Conclusion: The minor allele of the SLC16A11 gene (T) is highly prevalent among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects that may lead to type 2 diabetes.

ABSTRACT This article deals with some experiences developed by Cuban adolescents and young people during the beginning of the COVID-19 pandemic (march-august 2020) from their integration into youth organizations such as the Union of Young Communists, the University Student Federation and the Hermanos Saiz Association; other community organizations such as the Committees for the Defense of the Revolution and the Federation of Cuban Women, and a third group of a more spontaneous nature. There is in every case a reading of the lessons learned from these practices. Likewise, preliminary results of the research are offered: Youth trajectories and practices in times of the COVID 19 pandemic, which is part of a project in which several academic units of FLACSO in Latin America and the Caribbean are participating. Among the main results of the study is the active participation of young populations in the cooling to the pandemic, and the changes and adjustments they have had to make in their daily practices.

RESUMEN El presente artículo da cuenta de algunas experiencias llevadas a cabo por adolescentes y jóvenes cubanos durante los primeros meses de la pandemia de la COVID-19 (marzo-agosto 2020), a partir de su integración en organizaciones juveniles instituidas, como la Unión de Jóvenes Comunistas (UJC), la Federación Estudiantil Universitaria (FEU) y la Asociación Hermanos Saíz (AHS); otras vinculadas con organizaciones que actúan en el ámbito comunitario, como los Comités de Defensa de la Revolución (CDR) y la Federación de Mujeres Cubanas (FMC), y un tercer grupo de carácter más espontáneo. Para todos los casos se realiza una lectura de los aprendizajes aportados por estas prácticas. Asimismo, se ofrecen resultados preliminares de la investigación: Trayectorias y prácticas juveniles en tiempos de la pandemia de la COVID-19, que forma parte de un proyecto de carácter regional, en el que participan varias unidades académicas de FLACSO en América Latina y el Caribe. Entre estos se destaca la participación activa de las poblaciones jóvenes en el enfrentamiento a la pandemia, así como los cambios y ajustes que han tenido que realizar en sus prácticas cotidianas.

ABSTRACT Introduction: In the last years, there has been an exponential increase in childhood obesity rates worldwide. Although eating behavior depends on multiple factors, there is agreement on the impact of socio-environmental aspects in which the family has a central role. Identifying the influence of parents and caregivers on child eating behavior can help to generate effective strategies for controlling obesity, especially at early stages. Aim: To review recent scientific evidence on the association between parental feeding attitudes and practices, eating behavior and nutritional status of the child. Method: Narrative review of 40 empirical articles published between 2011 and 2019. Results: Parents tend to underestimate body weight in overweight children. Weight concern and pressure to eat are associated with the nutritional status of the child. Restrictive feeding and the use of food for instrumental purposes and as a mean of controlling emotions, would not be effective practices, possibly because they interfere with the child's ability to self-regulate intake. Positive practices included monitoring, modelling healthy eating patterns and creating non-obese environments. Conclusion: Consistent findings support the notion that coercive practices could have negative effects on child eating behavior. Moreover, practices that promote structured and a positive environment could be more functional. However, international evidence is consistent in the relevance of parents and caregivers in promoting healthy eating behavior and the nutritional status of children.

RESUMEN Introducción: si bien la conducta alimentaria depende de múltiples factores, existe acuerdo en la importancia de aspectos socio-ambientales en los que la familia tiene un rol central, especialmente en edades tempranas. Objetivo: sistematizar evidencia científica actualizada sobre la asociación entre actitudes y prácticas de alimentación infantil, conducta alimentaria y estado nutricional del niño. Método: revisión narrativa de 40 artículos empíricos publicados entre los años 2011 y 2019. Resultados: se identificó tendencia en los padres a subestimar el peso corporal en niños con sobrepeso, y asociación entre preocupación por el peso, presión para comer y estado nutricional del niño. La alimentación restrictiva y el uso de la alimentación para fines instrumentales y controlar emociones, no serían prácticas efectivas, posiblemente porque interfieren en la capacidad de autorregulación del niño. Prácticas positivas incluyeron monitoreo, modelado de patrones alimentarios saludables y creación de ambientes no obesogénicos. Conclusión: existen hallazgos consistentes respecto a que prácticas coercitivas pueden ejercer efectos negativos en la conducta alimentaria infantil y prácticas que promueven la estructuración en la alimentación y un entorno positivo, serían más funcionales. La evidencia internacional es consistente en la relevancia de padres y cuidadores en la promoción de una conducta alimentaria saludable y la condición nutricional de niños.

ABSTRACT Compliance with dietary guidelines is essential for adoopting a healthy lifestyle. This study aimed to characterise the lifestyles of the Chilean population according to the fulfilment of 5 recommendations of the Food-Based Dietary Guidelines (GABA in Spanish) established in Chile according to WHO definition. Data from the 2016-2017 National Health Survey were used. Participants were divided into four groups: those who did not meet any recommendations, those who met one, those who met two and those who met three or more (reference group) GABA health recommendations. 43.3% of the sample did not meet any of the recommendations incorporated into this study. Of those who fulfilled at least three recommendations, 35.9% had a normal nutritional status, 38.9% reported never having smoked, and 82% perceived themselves as healthy. In addition, those who fulfilled the recommendations presented higher levels of physical activity (1343.5 MET/min/day [95% CI: 1049.9 - 1637.2]). From the results, it is inferred that people who incorporate and apply GABA recommendations tend to present healthier life behaviours. Consequently, effective and formative communication strategies in food education on these recommendations are crucial to preventing a fast and early growth of chronic diseases.

RESUMEN Cumplir las recomendaciones incluidas en las Guías Alimentarias permite un acercamiento hacia un estilo de vida saludable. El objetivo de este estudio fue caracterizar los estilos de vida de la población chilena y su asociación al cumplimiento de 5 recomendaciones de las Guías Alimentarias Basadas en Alimentos (GABA) chilenas. Se utilizaron datos de la Encuesta Nacional de Salud 2016-2017. Los participantes fueron divididos en 4 grupos: aquellos que no cumplieron con ninguna recomendación, los que cumplían una, los que cumplían con 2 y los que cumplían con 3 o más recomendaciones saludables, estableciendo a este último como grupo de referencia. El 43,3% de la muestra no cumplió ninguna de las recomendaciones incorporados en esta investigación. De los que cumplían a lo menos 3, el 35,9% presentó un estado nutricional normal, el 38,9% reportó nunca haber fumado y el 82% se auto percibía como saludable. Además, los que cumplían las recomendaciones, presentaron niveles más altos de actividad física. Personas que incorporan y aplican las recomendaciones de las GABA, tienden a presentar conductas de vida más saludable. Estrategias comunicacionales efectivas y formativas en educación alimentaria sobre estas recomendaciones son claves para prevenir el acelerado y temprano crecimiento de las patologías crónicas.

ABSTRACT Introduction: Determining level of physical activitY (PA) can be done with objective measurement, through accelerometer, or by subjective measurement through self-report questionnaire. The aim of this study was to compare PA measurements derived from a self-reported questionnaire and accelerometer according to sociodemographic factors in the Chilean population. Methods: This was a cross-sectional study which included 230 Chilean adults participating in the GENADIO study (Genes, Environment, Diabetes and Obesity). PA levels were measured through the International Physical Activity Questionnaire (IPAQ) and GT1M accelerometer (ActiTrainer, ActiGraph). Results: IPAQ questionnaire underestimated the total PA levels compared to the accelerometer measurement (delta[IPAQ-Acel.]= −55.7 min/day). According to educational level, IPAQ questionnaire overestimated PA level in people with low educational level (delta[IPAQ-Accel.]= 70.4 min/day), but underestimated total PA in people with secondary education or university technician (delta[IPAQ-Accel.]=-67.9 and-135.6 min/day, respectively). Similar results were observed for the different levels of socioeconomic income. Conclusion: The IPAQ questionnaire underestimated total PA levels compared to accelerometer; however, these differences varied according to sociodemographic factors.

RESUMEN Introducción: La determinación del nivel de actividad física (AF) puede realizarse a través de acelerómetro o mediante cuestionario de auto-reporte. El objetivo de este estudio fue comparar los niveles de AF entre un cuestionario de auto-reporte y la medición con acelerómetro de movimiento según factores sociodemográficos en la población chilena. Métodos: Estudio de corte transversal que incluyó a 230 adultos chilenos participantes del proyecto Genes, Ambiente, Diabetes y Obesidad (GENADIO). Niveles de AF fueron medidos mediante el cuestionario Internacional Physical Activity Questionnaire (IPAQ) y acelerómetro de movimiento (ActiGraph). Resultados: IPAQ subestimó los niveles de AF total en comparación a la medición con acelerómetro (delta [IPAQ-Acel.]= −55,7 min/día). Según nivel educacional, se evidenció que el cuestionario IPAQ sobreestimó los niveles de AF total en personas con bajo nivel educacional (delta [IPAQ-Acel.]= 70,4 min/día), pero subestimó la AF total en personas con enseñanza media o técnico universitaria (delta [IPAQ-Acel.]= −67,9 y −135,6 min/día, respectivamente). Resultados similares fueron observados para los distintos niveles de ingreso socioeconómico (NSE). Conclusión: El cuestionario de auto-reporte IPAQ subestimó los niveles de AF total en comparación a la medición por acelerómetro; sin embargo, estas diferencias variaron según factores sociodemográficos.

Background: Depression has been previously associated with cognitive impairment in high income country populations. However, its association in the Chilean population has not been investigated. Aim: To investigate the association between depression and cognitive impairment. Material and Methods: Data from 1384 Chilean adults aged > 60 years, participating in the National Health Survey 2009-2010 was analyzed. Cognitive impairment was assessed using the Mini Mental Examination score. The medical diagnosis of depression was self-reported. The association between depression and cognitive impairment was assessed using a logistic regression. Results: Depression was positively associated with cognitive impairment. However, the magnitude of the association was higher in men (Odds ratio (OR) = 4.02 [95% confidence intervals (CI): 1.44; 6.61], p < 0.01]) than in women (OR = 2.23 [95%CI: 1.03; 3.43], p = 0.04). Older adults who were diagnosed for the first time with depression after 65 years of age, showed a stronger association with cognitive impairment (OR = 6.65 [95% CI: 2.39; 10.9], p < 0.01) than those diagnosed before 55 years. Conclusions: Our study confirms the association between depression and cognitive impairment. Further research is needed to elucidate the nature and potential mechanisms that link depression with cognitive impairment.

Background: Sugar intake is a risk factor for the development of obesity. Aim: To investigate the association between total sugar intake and obesity markers in Chilean adults. Material and Methods: This cross-sectional study included 396 participants of the GENADIO study. Anthropometric measurements (body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio, and % body fat) were measured through standardized protocols. Total sugar intake was determined from a 7-days weighted food daily. Sugar intake expressed in g/day was categorized into quartiles. Results: Higher sugar intake was associated with a higher BMI, WC and HC but not with body fat %. One quartile increment in sugar intake was associated with 1.50 kg [95% confidence interval (CI): 0.49; 2.50] higher body weight, 0.34 kg/m2 [95% CI: 0.01; 0.69] higher BMI, 1.23 cm [95% CI: 0.11; 2.34] higher WC, 1.39 cm [95% CI: 0.28; 2.50] higher HC and 0.02 the waist-to-hip ratio [95% C: 0.01; 0.02]. Conclusions: Total sugar intake was associated with higher adiposity levels in these Chilean adults.

Ageing will be one of the most significant social transformations of the 21st century worldwide. In the last 40 years, Chile has tripled its older adult population. As a result, by 2050 the country will have the highest proportion of older adults in Latin America. This remarkable growth reinforces the need to identify their current situation and to revise what is the society doing to maintain older people as active members. In this context, this narrative revision aimed to describe the sociodemographic, epidemiologic and sociocultural profile of the older Chilean adults. Besides, programs and public policies focused on the improvement of their quality of life were identified.

Abstract: Introduction: Obesity is considered a chronic inflammatory disease with an important genetic component. Although several studies have reported an association between the FTO (fat-mass associated gene) and adiposity in children, there is limited evidence in the Chilean population. Objective: To deter mine the association between the polymorphism rs9939609 of the FTO gene and markers of adipo sity in Chilean children. Patients and Method: Cross-sectional study which included 361 children aged between 6 and 11 years (50% were girls). Between March and June 2008, clinical data and blood sample collection was carried out. The rs9939609 single-nucleotide polymorphism (SNP) of the FTO gene, was determined using the genomic DNA extracted from leukocytes, using the QIAamp DNA Blood Mini Kit (Qiagen GmbH, Hilden, Germany).The adiposity markers included were body mass index (BMI), waist circumference (WC), body fat, and WC/H index; which were later compared adjusted by sex, age, and Tanner stage. Linear regression analyses were conducted to detect the association between the polymorphism and obesity markers. Results: After adjusting the models by age, sex, and Tanner stage, we found a significant association between the polymorphism and markers of adiposity. For each extra copy of the risk allele, we found an increase of 2.47 kg body weight (95% CI: 1.39-3.55); 1.06 kg/m2 BMI (95% CI: 0.56-1.54); 2.55 cm WC, (95% CI: 1.26-3.85); and 1.98% body fat (95% CI: 0.78-3.19). When converting adiposity markers to z-score, we found that WC/height index shows the strongest association with the risk allele FTO. Conclusion: This study supports the association between the rs9939609 SNP of the FTO gene and overall and central adiposity markers in Chilean children.

Resumen: Introducción: La obesidad es una enfermedad inflamatoria donde la genética determina cierto nivel de riesgo. Aun cuando existen estudios que reportan asociación entre polimorfismos de FTO (fat-mass associated gene) y adiposidad, existe limitada evidencia en población infantil chilena. Objetivo: determinar la asociación entre el polimorfismo rs9939609 del FTO y marcadores de adiposidad en población in fantil chilena. Pacientes y Método: Estudio de corte transversal incluyó 361 participantes (de 6 a 11 años; 50% niñas). Los datos clínicos y la recolección de muestras de sangre se realizaron entre marzo y junio de 2008. El polimorfismo SNP (rs9939609), del gen FTO, se determinó utilizando ADN genómico extraído de leucocitos, utilizando el Mini Kit QIAamp DNA Blood (Qiagen GmbH, Hilden, Alemania). Los marcadores de adiposidad estudiados fueron, índice de masa corporal (IMC), masa grasa, perímetro de cintura (PC) y razón cintura/talla, y se compararon ajustados por sexo, edad y estadio de Tanner. La asociación entre el polimorfismo estudiado y los marcadores de obesidad se realizó mediante análisis de regresión lineal. Resultados: Al ajustar los marcadores por sexo, edad y estadío de Tanner se observó una asociación significativa entre el polimorfismo e indicadores de adi posidad. Por cada copia extra del alelo de riesgo se encontró un aumento de 2,47 kg de peso corporal, (IC 95%: 1,39-3,55); 1,06 kg/m2 de IMC, (IC 95%: 0,56-1,54); 2,55 cm de PC, (IC 95%: 1,26-3,85) y 1,98% de masa grasa, (IC 95%: 0,78-3,19). Al convertir los marcadores de adiposidad a z-score, la razón perímetro de cintura/talla arrojó la mayor asociación con el alelo de riesgo de FTO. Conclu sión: Este estudio indica asociación entre el polimorfismo rs9939609 del gen FTO con marcadores de adiposidad general y central en población infantil en Chile.

ABSTRACT The aim was to review the evidence supporting the possible health benefits for obesity of breastfeeding versus formula feeding in infants. The search for studies addressing this topic was conducted in PubMed, Web of Science and Scielo databases. “Breastfeeding”, “formula feeding” and “obesity” were the keywords used in the search. Only studies with a full version of the manuscript were included. The evidence analyzed indicated that children fed exclusively through breastfeeding reported low levels of overweight and obesity in comparison to those fed by infant milk formulas. To conclude, exclusive breastfeeding until the sixth month of life, and supplementation with solid (non-dairy) food until two years and more, is the gold standard and could protect against childhood obesity and its associated comorbidities in adult life.

RESUMEN El objetivo del trabajo fue analizar el posible efecto protector de la lactancia materna respecto a la obesidad infantil versus fórmulas lácteas. Se consultaron las bases de datos PubMed, Web of Science y Scielo, considerándose los artículos más actualizados sobre el tema. La evidencia analizada señala que los menores alimentados con lactancia materna exclusiva reportan bajos niveles de sobrepeso y obesidad, a diferencia de los alimentados con fórmulas lácteas infantiles. Se concluye que la lactancia materna exclusiva, hasta el sexto mes de vida del lactante, y complementada con alimentación solida (no láctea) hasta los dos o más años, es recomendada y podría proteger contra la obesidad infantil y sus comorbilidades asociadas en la vida adulta.