Abstract In goal-oriented conversational agents like Chatbots, finding the similarity between user input and representative text result is a big challenge. Generally, the conversational agent developers tend to provide a minimal number of utterances per intent, which makes the classification task difficult. The problem becomes more complex when the length of the representative text per action is short and the length of the user input is long. We propose a methodology that derives Sentence Similarity score based on N-gram and Sliding Window and uses the FastText Word Embeddings technique which outperforms the current state-of-the-art Sentence Similarity results. We are also publishing a dataset on the shopping domain, to build conversational agents. And the extensive experiments done on the dataset fetched better results in accuracy, precision and recall by 6%, 2% and 80% respectively. It also evinces that our solution generalizes well on the low corpus and requires no training.

The role of G-protein activation in cardiovascular disorders is well-known. G-protein β3 subunit (GNB3) C825T polymorphism is associated with increased intracellular signal transduction. We investigated the role of the variant in plasma sodium and potassium concentrations and association with hypertension. 345 healthy controls and 455 patients with essential hypertension were enrolled. Plasma renin activity and aldosterone concentration were measured. The variant, typed by SNaPshot, was analyzed on an ABI Prism 3100 Genetic Analyzer and GeneScan. The TT genotype and T allele were over-represented in the patients (p < 0.001, p < 0.0001). Multiple-logistic regression disclosed that the risk of hypertension was significantly greater for TT (p < 0.0001, OR = 6.1, CI = 2.9-12.7). One-way ANOVA revealed that hypertensive T-allele carriers (CT+TT), compared to non-carriers (CC), had a greater body mass index (BMI), mean arterial pressure (MAP) and PAC (p = 0.01, p = 0.01, p < 0.0001, respectively); while the patients with 825TT risk genotype showed higher plasma sodium and lower potassium (p < 0.0001, each). The results strongly emphasize, not only the role of C825T polymorphism by the induction of increased G-protein activity and enhancement of Na/h exchangers, but also the association with higher plasma sodium and lower potassium levels, high BMI and susceptibility to hypertension.