Abstract: The effects of low molecular weight phenol formaldehyde resin on weathering durability property of sweetgum (Liquidambar styraciflua) and southern pine (Pinus taeda) specimens were studied using six wet-dry cycles with ultraviolet light accelerated weathering test following ASTM via evaluating the water repellent efficiency, dimensional stability, and crack formation of wood. The results showed that 1) the water repellent efficiency of treated quarter-sawn sweetgum specimens was higher than those of treated quarter-sawn and flat-sawn southern pine specimens; 2) the dimensional stabilities of sweetgum and southern pine specimens were all improved by impregnating low molecular weight phenol formaldehyde resin, especially for sweetgum; 3) there were clearly more cracks on exposed ends and surfaces of all treated sweetgum and southern pine specimens than those on control ones, indicating that the low molecular weight phenol formaldehyde resin modification used in this study were not able to improve the anti-cracking properties of sweetgum and southern pine specimens. Generally, the sweetgum was more suitable to be impregnated with low molecular weight phenol formaldehyde resin than southern pine with the procedure described according to dimensional stability and water repellent efficiency, in order to improve the weathering durability.

Abstract: The compressive stress relaxation behaviors in three directions of beech (Fagus orientalis) were studied by experiments, and predicted by mechanical model and finite element method. Firstly, short-term (3 hours) compressive stress relaxation experiments were carried out in longitudinal (L), radical (R) and tangential (T) directions of beech, and then the experimental data was fitted by mechanical model with two single Maxwell bodies in parallel connection. Secondly, the method of predicting the long-term (12 hours) stress relaxation behaviors of beech based on the finite element method was studied using the experimental data of short-term stress relaxation. Finally, the long-term stress relaxation behaviors in three directions of beech were investigated by experiments, mechanical model and finite element method respectively, and the results of them were compared. The results showed that stress relaxation behaviors of beech were different in three directions, and the short-term stress relaxation in L was much smaller than those in R and T directions under the same load. Besides, the mechanical model with two single Maxwell bodies in parallel connection was capable of predicting the short-term relaxation behaviors of beech in three directions with correlation coefficients beyond 0,99 but it did not work in long-term relaxation. In addition, the errors of FEM were smaller than those of the mechanical model compared with the results of experiments in the long-term stress relaxation, and the errors of the FEM were approximately 8% in L and 20% in R and T directions, which were all accepted in the field of wood engineer. This study will contribute to predict the long-term relaxation behaviors of wood products and wooden structures based on the FEM.

Abstract Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN). Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups. Results: Compared with NC group, the RBT, FBG, HbA1c, TPU, BUN, Cr, and RMM in DN group were significantly increased (P < 0.05), the IGF-1, FN, and Col-IV were significantly upregulated (P < 0.05), while MMP was significantly downregulated (P < 0.05). Compared with DN group, the indexes except for the FBG and HbA1c in DN+RAM group were significantly improved (P < 0.05), among which IGF-1 exhibited significant positive correlation with TPU(r=0.937), FN(r=0.896) and Col-IV(r=0.871), while significant negative correlation with MMP-2 (r=-0.826) (P<0.05). Conclusion: RAM may protect the kidneys by suppressing IGF-1 and mitigating the accumulation of RMM.

Objetivo: Buscamos testar os efeitos de diferentes doses de pioglitazona (PIO) sobre a expressão glomerular de podocalixina e sobre a excreção de podocalixina em células do sedimento urinário, além de explorar o potencial mecanismo de proteção renal. Materiais e métodos: O diabetes tipo 1 foi induzido em 36 ratos Sprague-Dawley machos com estreptozotocina (65 mg/kg). Os animais foram tratados apenas com o veículo, ou com 10, 20, 30 mg/kg/d de PIO por 8 semanas. Oito ratos foram colocados no grupo controle. Resultados: Na oitava semana, os ratos foram sacrificados para se observar a lesão renal em microscopia eletrônica. A produção de podocalixina glomerular, incluindo mRNA e proteína, foi determinada por RT-PCR e imuno-histoquímica, respectivamente. Os níveis urinários de albumina e podocalixina nas células do sedimento urinário e o índice de lesão renal estavam todos significativamente aumentados, enquanto a expressão glomerular da proteína podocalixina e do mRNA estava significativamente diminuída em ratos diabéticos comparados com o controle normal. A análise dos efeitos dose-dependentes revelou que o efeito protetor da PIO melhorou as mudanças fisiopatológicas e atingiu um pico na dose de 20 mg/kg/dia. Conclusão: A PIO pode melhorar a injúria renal de forma dose-dependente e este papel pode estar associado com a prevenção da excreção de podocalixina nas células do sedimento urinário e com a preservação da expressão glomerular de podocalixina.

Objective: We sought to test the effect of different dosages of pioglitazone (PIO) on the glomerular expression of podocalyxin and urinary sediment podocalyxin excretion and to explore the potential renoprotective mechanism. Materials and methods: Type 1 diabetes induced with streptozotocin (65 mg/kg) in 36 male Sprague-Dawley rats were randomly allocated to be treated with vehicle or 10, 20, 30 mg/kg/d PIO respectively for 8 weeks. Eight rats were enrolled in the normal control group. Results: At 8th week, rats were sacrificed for the observation of kidney injury through electron microscope. Glomerular podocalyxin production including mRNA and protein were determined by RT-PCR and immunohistochemistry respectively. Levels of urinary albumin excretion and urinary sediment podocalyxin, kidney injury index were all significantly increased, whereas expression of glomerular podocalyxin protein and mRNA were decreased significantly in diabetic rats compared to normal control. Dosages-dependent analysis revealed that protective effect of PIO ameliorated the physiopathological changes and reached a peak at dosage of 20 mg/kg/d. Conclusion: PIO could alleviate diabetic kidney injury in a dose-dependent pattern and the role may be associated with restraining urinary sediment podocalyxin excretion and preserving the glomerular podocalyxin expression.