Abstract Heart Failure (HF) has been one of the leading causes of death worldwide. Though its latent mechanism and therapeutic manipulation are updated and developed ceaselessly, there remain great gaps in the cognition of heart failure. High morbidity and readmission rates among HF patients are waiting to be addressed. Recent studies have found that myocardial energy metabolism was closely related to heart failure, in which substrate utilization, as well as intermediate metabolism disorders, insulin resistance, oxidative stress, and mitochondrial dysfunction, might underlie systolic dysfunction and progression of HF. This article centers on the changes and counteraction of cardiac energy metabolism in the failing heart. Therefore, targeting impaired energy provision is of great potential in the treatment of HF. And shifting the objective from traditional neurohormones to improving the cellular environment is expected to further optimize the management of HF. (HF worldwide ceaselessly failure addressed utilization disorders resistance stress Therefore

PURPOSE: The visual storytelling feature of Instagram provides luxury fashion brands with an appropriate platform to enhance their online presence and identity to build a greater connection with their audiences. This paper aims to examine how digital brand experiences on social media influence perceptions of brand authenticity, attachment and loyalty for luxury fashion brands DESIGN/METHODOLOGY/APPROACH: This study adopts a quantitative analysis by collecting data with a survey-based approach of 112 respondents who are luxury brand Instagram followers. The empirical testing and estimation of the proposed model were carried out using the partial least squares structural equation modelling (PLS-SEM FINDING/RESULTS: Results of this study showed that digital brand experiences determine the audiences' positive attitudes towards brand authenticity, attachment and loyalty. Brand authenticity and attachment were found to partially mediate the digital brand experiences and brand loyalty PRACTICAL IMPLICATIONS: Brand authenticity can be understood as an important key to a brand's social media presence, and authenticity will significantly enhance attachment in consumers' minds. Physical experience should be integrated with the digital brand experience. In conclusion, audiences equivalate digital brand experiences as authentic feelings, generating attachment and loyalty to a luxury fashion brand ORIGINALITY/VALUE: This research presents insights about digital brand experiences and related essential constructs in the context of the luxury fashion brand; moreover, this study offers valuable implications in practical terms for the operation of social media platforms

Silica gel was chemically modified with polyelectrolyte and used as a solid phase extraction adsorbent for the determination of trace silver in environmental water samples by flame absorption spectrometry (FAAS). The effects of pH, sample flow rate and volume, elution conditions and co-existing ions on the recovery of the analyte were investigated. The results showed that silver could be adsorbed at pH 5.0 and eluted by 5.0 mL 2% thiourea in HNO3 (0.1 mol L-1). Under the optimized conditions, the adsorption capacity of modified silica gel was found to be 8.6 mg g-1 for silver. The detection limit of the proposed method was 1.0 ng mL-1 for silver with an enrichment factor of 18.7. The analytical result for the certified reference water sample (GBW08610) was in a good agreement with the certified value. The proposed method has also been successfully applied to the determination of trace silver in drinking water, well water, snow water and waste water with the recoveries for spiked samples between 94% and 105%.