São relatados 5 casos de doença de Marchiafava-Bignami, estudados em seus aspectos anátomo-patológicos, de correlação clínica e de etiopatogenia. O aspecto anátomo-patológico, de desmielinização na parte central do corpo caloso, comprometendo também outras comissuras, é característico da doença. Os autores chamam a atenção para o papel do alcoolismo e da desnutrição na patogênese da lesão e para a predominância, nesta série, de casos do sexo feminino, ocorrência rara entre os casos descritos na literatura.

The clinicopathological study of five autopsied cases of Marchiafava-Big-nami disease is reported. The demielination of the central portion of the. corpus callosum is the major characteristics of the disease. In two cases the demielination also involved the anterior and posterior commissures. There is a clear relationship to alcoholism land malnutrition in the cases reported in the present study.

Immunological tolerance to Schistosoma mansoni antigens induced by oral exposure of neonatal and adult mice to adult worm, soluble egg and polysaccharide antigens conducted to modulated periovular granuloma of infected mice. However the tolerance do not interfere in the infection. The estimative population and subpopulation of lymphocytes in the spleen of tolerized (not infected) animals do not differ from normal animals but Lyt 2.2 reactive lymphocytes to Schistosoma antigens was demonstrated in the tolerized animals.