ABSTRACT Introduction: Chronic Kidney Disease has gained interest due to its high morbidity and mortality rate. In addition to vascular causes and diabetes mellitus, an unknown cause has been identified in young farmers. Objective: This study aims to determine the prevalence of the population on hemodialysis, suspected of Chronic Interstitial Nephritis in agricultural communities, to categorize the true etiology of their renal pathology. Methodology: A descriptive observational design was applied during December 2022, January, and February 2023; and 684 patients of both sexes were surveyed in 8 hemodialysis centers in the Capital and the Central Department of Paraguay. Results: The prevalence of suspected cases due to the exposure to risk factors was 18.1%. This figure could be higher since 22.6% of patients with type 2 diabetes mellitus did not present clinical retinopathy or other clinical signs of the disease at the time of the diagnosis of kidney failure. This scenario warns us of a probable misdiagnosis in a considerable number of patients. Conclusion: The importance of this research lies in generating preventive actions in the agricultural population and raising awareness in the medical community about the diagnostic relevance of this pathology to improve the quality and prognosis of life in the Paraguayan population.

RESUMEN Introducción: La Enfermedad Renal Crónica ha cobrado interés debido a su alta tasa de morbimortalidad. Además de las causas vasculares y de la diabetes mellitus, se ha identificado una causa de Origen Desconocido en jóvenes agricultores. Objetivo: El objetivo del estudio es determinar la prevalencia de la población en hemodiálisis, sospechosa de la Nefritis Intersticial Crónica en Comunidades Agrícolas, para categorizar la verdadera etiología de su patología renal. Metodología: Se aplicó un diseño observacional descriptivo durante los meses de diciembre de 2022, enero y febrero de 2023; y se encuestó a 684 pacientes de ambos sexos en 8 centros de hemodiálisis de la Capital y el Departamento Central del Paraguay. Resultados: La prevalencia de casos sospechosos por la exposición a factores de riesgo resultó ser del 18.1%. Esta cifra podría ser mayor, ya que 22.6% de los pacientes con diabetes mellitus tipo 2, no presentó retinopatía clínica ni otros signos clínicos de la enfermedad al momento del diagnóstico de la falla renal. Este panorama nos advierte de un probable diagnóstico desacertado en una cantidad considerable de pacientes. Conclusión: La importancia de esta investigación se sustenta en generar acciones preventivas en la población agrícola y concientizar a la sociedad médica de la relevancia diagnóstica de esta patología para mejorar la calidad y pronóstico de vida en la población paraguaya.

ABSTRACT Objective: After initial treatment, up to 30% of patients with papillary thyroid cancer (PTC) have incomplete response, mainly cervical lymph node (LN) disease. Previous studies have suggested that active surveillance (AS) is a possible option for these patients. Our aim was to report the results of AS in patients with PTC and cervical LN disease. Materials and methods: In this retrospective observational study, we included adult patients treated and followed for PTC, who presented with cervical LN disease and were managed with AS. Growth was defined as an increase ≥ 3mm in either diameter. Results: We included 32 patients: 27 (84.4%) women, age of 39 ± 14 years, all initially treated with total thyroidectomy, and 22 (69%) with therapeutic neck dissection. Cervical LN disease was diagnosed 1 year (0.3-12.6) after initial management, with a diameter of 9.0 mm (6.0-19.0). After a median AS of 4.3 years (0.6-14.1), 4 (12.5%) patients had LN growth: 2 (50%) of whom were surgically removed, 1 (25%) was effectively treated with radiotherapy, and 1 (25%) had a scheduled surgery. Tg increase was the only predictive factor of LN growth evaluated as both the delta Tg (p < 0.0366) and percentage of Tg change (p < 0.0140). None of the included patients died, had local complications due to LN growth or salvage therapy, or developed distant metastases during follow-up. Conclusions: In selected patients with PTC and suspicious cervical LNs diagnosed after initial treatment, AS is a feasible and safe strategy as it allows effective identification and treatment of the minority of patients who progress. Objective 30 (PTC response (LN (AS methods study Results 3 84.4% 844 84 (84.4% women thyroidectomy 69% 69 (69% dissection 0.312.6 03126 0.3 12.6 0 12 6 (0.3-12.6 management 90 9 9. 6.019.0. 60190 6.0 19.0 . 19 (6.0-19.0) 43 4. 0.614.1, 06141 0.6 14.1 , (0.6-14.1) 12.5% 125 5 (12.5% 50% 50 (50% removed 25% 25 (25% radiotherapy surgery p 0.0366 00366 0366 0.0140. 00140 0.0140 0140 0.0140) died therapy followup. followup follow up. follow-up Conclusions progress 84.4 8 (84.4 (69 312 0.312. 0312 03 0. 126 12. (0.3-12. 019 6.019.0 6019 60 6. 190 19. (6.0-19.0 614 0.614.1 0614 06 141 14. (0.6-14.1 12.5 (12.5 (50 (25 0.036 0036 036 0014 0.014 014 84. (84. (6 31 0.312 031 (0.3-12 01 6.019. 601 (6.0-19. 61 0.614. 061 (0.6-14. (12. (5 (2 0.03 003 001 0.01 (84 ( 0.31 (0.3-1 6.019 (6.0-19 0.614 (0.6-14 (12 0.0 00 (8 (0.3- 6.01 (6.0-1 0.61 (0.6-1 (1 (0.3 (6.0- (0.6- (0. (6.0 (0.6 (0 (6.

Abstract: Individuals of Laridae family play an important role in functional ecology of marine and coastal environments, and have been described as bioindicators of ichthyofauna, however, knowledge about these birds in southwestern Gulf of Mexico is limited. The objective of the present study was to study Laridae family assemblages and migratory patterns along Barra Norte beach coastline, Veracruz State, southwestern Gulf of Mexico. During 2014-2015 winter migratory season, three monthly samplings were conducted along 1 km x 600 m line transects. The assemblages were approached through diversity indices (Pielou's equity, Simpson's dominance and true diversity) and dominant species (characterized by a percentage similarity analysis). Migration was studied with a partial canonical correspondence analysis. A total of 3,314 organisms grouped into 14 species were recorded. Equity was highest in April and dominance in February. The dominant species were Leucophaeus atricilla, Thalasseus maximus, T. acuflavidus and Hydroprogne caspia. Three migratory patterns were found and coincide with the rainy, northerly and dry seasons. Each pattern contains particular species assemblages. The first pattern occurs from August to October 2014 (Sterna hirundo, T. acuflavidus and Chlidonias niger), the second from November 2014 to February 2015 (Larus delawarensis, L. californicus, L. argentatus smithsonianus, L. atricilla, H. caspia and Rissa trydactila) and the last one covers April and May 2015 (Rynchops niger, Sternula antillarum and L. pipixcan). Results establish that larids community assemblage is composed of a multiple migratory pattern.

Resumen: Los representantes de la familia Laridae tienen un rol importante en la ecología funcional de los ambientes marinos y costeros, por lo que han sido descritos como bioindicadores de la ictiofauna, sin embargo, el conocimiento sobre estas aves en el suroeste del golfo de México es limitado. El objetivo del presente estudio fue estudiar los ensambles y patrones migratorios de la familia Laridae en la línea costera de la playa Barra Norte, Estado de Veracruz, suroeste del golfo de México. Durante la temporada migratoria invernal 2014-2015 se realizaron tres muestreos mensuales a través de transectos lineales de 1 km x 600 m. Los ensambles se abordaron a través de índices de diversidad (equidad de Pielou, dominancia de Simpson y de diversidad verdadera) y especies dominantes (caracterizadas por un análisis de similitud porcentual). Con un análisis de correspondencia canónico parcial se estudió su migración. Se registraron 3.314 organismos agrupados en 14 especies. La equidad fue más alta en abril y la dominancia en febrero. Las especies dominantes fueron Leucophaeus atricilla, Thalasseus maximus, T. acuflavidus e Hydroprogne caspia. Se encontraron tres patrones migratorios que coinciden con las temporadas de lluvias, nortes y secas. Cada patrón contiene particulares ensambles de especies. El primer patrón ocurre de agosto a octubre 2014 (Sterna hirundo, T. acuflavidus y Chlidonias niger), el segundo de noviembre 2014 a febrero 2015 (Larus delawarensis, L. californicus, L. argentatus smithsonianus, L. atricilla, H. caspia y Rissa tridactyla), y el último abarca abril y mayo 2015 (Rynchops niger, Sternula antillarum y L. pipixcan). Los resultados establecen que el ensamblaje comunitario de los láridos se compone de un patrón migratorio múltiple.

Resumen: El objetivo es identificar aquellas dimensiones con sus indicadores que sean detonantes para una correcta transferencia del conocimiento para el desarrollo de competencias en la formación de docentes universitarios permitiendo el desarrollo de gestiones administrativas. El método de investigación utilizado es de ecuaciones estructurales PLS-SEM con una muestra de 215 sujetos pertenecientes al Tecnológico Nacional de México. Los resultados muestran dimensiones como desarrollo tecnológico, comunicación social-afectiva e innovación didáctico-pedagógica siendo significativos y determinantes para la transferencia del conocimiento. Los hallazgos muestran que la dimensión didáctico-pedagógica en la formación del profesorado tiene mayor impacto en la transferencia del conocimiento respecto a las otras. Su originalidad radica en que aporta evidencia empírica y detona un modelo para la gestión y desarrollo de competencias profesionales específicas para el profesorado universitario que garantice la correcta TC, su limitante es que la muestra se tomó antes de la pandemia.

Abstract: The objective of identifying those dimensions with their indicators that are triggers for a correct transfer of knowledge for the development of skills in the training of university teachers, allowing the development of administrative procedures. The importance of the research lies in the objective of identifying those dimensions with their indicators that are triggers for a correct transfer of knowledge for the development of skills in the training of university teachers, allowing the development of administrative procedures. La importancia de la investigación radica en el objetivo de identificar aquellas dimensiones con sus indicadores que sean detonantes para una correcta transferencia de conocimientos para el desarrollo de competencias en la formación de docentes universitarios, permitiendo el desarrollo de procedimientos administrativos. The importance of the research lies in the objective of identifying those dimensions with their indicators that are triggers for a correct transfer of knowledge for the development of competencies in the training of university teachers, allowing the development of administrative procedures. La importancia de la investigación radica en el objetivo de identificar aquellas dimensiones con sus indicadores que sean detonantes para una correcta transferencia de conocimientos para el desarrollo de competencias en la formación de docentes universitarios, permitiendo el desarrollo de procedimientos administrativos. No se pudieron cargar todos los resultados Reintentar Volviendo a intentar… The research method used is PLS-SEM structural equations with a sample of 215 subjects belonging to the Tecnológico Nacional de México. The research method used is PLS-SEM structural equations with a sample of 215 subjects belonging to the Tecnológico Nacional de México. El método de investigación utilizado es ecuaciones estructurales PLS-SEM con una muestra de 215 sujetos pertenecientes al Tecnológico Nacional de México. The research method used is PLS-SEM structural equations with a sample of 215 subjects belonging to the National Technological Institute of Mexico. El método de investigación utilizado es ecuaciones estructurales PLS-SEM con una muestra de 215 sujetos pertenecientes al Instituto Tecnológico Nacional de México. No se pudieron cargar todos los resultados Reintentar Volviendo a intentar… The results show dimensions such as technological development, social-affective communication and didactic-pedagogical innovation, being significant and decisive for the transfer of knowledge. The results show dimensions such as technological development, social-affective communication and didactic-pedagogical innovation, being significant and decisive for the transfer of knowledge. Los resultados muestran dimensiones como el desarrollo tecnológico, la comunicación socio-afectiva y la innovación didácticopedagógica, siendo significativas y determinantes para la transferencia de conocimientos. The results show dimensions such as technological development, social-affective communication, and didactic-pedagogical innovation, being significant and decisive for knowledge transfer. Los resultados muestran dimensiones como el desarrollo tecnológico, la comunicación socio-afectiva y la innovación didáctico-pedagógica, siendo significativas y decisivas para la transferencia de conocimiento. No se pudieron cargar todos los resultados Reintentar Volviendo a intentar… The findings show that the didactic-pedagogical dimension in teacher training has a greater impact on knowledge transfer than the others. The findings show that the didactic-pedagogical dimension in teacher training has a greater impact on knowledge transfer than the others. Los hallazgos muestran que la dimensión didácticopedagógica en la formación docente tiene un mayor impacto en la transferencia de conocimientos que las demás. The findings show that the didactic-pedagogical dimension in teacher training has a greater impact on the transfer of knowledge compared to the others. Los hallazgos muestran que la dimensión didáctico-pedagógica en la formación docente tiene un mayor impacto en la transferencia de conocimientos en comparación con las demás. No se pudieron cargar todos los resultados Reintentar Volviendo a intentar… Its originality lies in the fact that it provides empirical evidence and triggers a model for the management and development of specific professional skills for university teaching staff that guarantees the correct TC, its limitation is that the sample was taken before the pandemic.

Resumen Antecedentes: En el Área Natural Protegida Sistema Arrecifal Lobos-Tuxpan (SALT), México, la presencia de babosas marinas se ha documentado en varias investigaciones científicas, pero la información es limitada, se encuentra dispersa y desactualizada. Objetivo: Elaborar una lista actualizada de las especies con base en la adición de nuevos datos de campo y de la compilación de especies reportadas previamente en la literatura para el SALT. Métodos: Se realizaron muestreos en el arrecife Lobos (durante noviembre 2014 y 2017), arrecife Enmedio (septiembre 2016, abril 2017, junio 2018, julio y noviembre 2019) y en el arrecife Tuxpan (junio y octubre 2016, y abril 2017). El listado de especies se complementó con registros de especies reportadas previamente para el SALT. Resultados: La lista actualizada comprende 27 especies de babosas marinas. Los grupos más representativos son: orden Cephalaspidea con nueve especies, Aplysiida con siete especies y Superorden Sacoglossa con siete especies. Se extiende la distribución de Cyerce habanensis y Elysia cornigera para el norte de Veracruz y Lobiger souverbii constituye nuevo registro para el Corredor Arrecifal del Suroeste del Golfo de México. Conclusiones: La presente investigación incrementa favorablemente el conocimiento de las babosas marinas para el SALT. Esta información puede apoyar las estrategias de conservación y protección para el plan de manejo de esta área natural protegida.

Abstract Background: In the Lobos-Tuxpan Reef System Protected Natural Area (LTRS), Mexico, the presence of sea slugs has been documented in several scientific investigations, but the information is limited, scattered and out of date. Goals: To elaborate an updated list of species with new field data and the compilation of species previously reported in the literature for LTRS. Methods: Samplings were carried out in the Lobos reef (during November 2014 and 2017), Enmedio reef (September 2016, April 2017, June 2018, July and November 2019) and the Tuxpan reef (June and October 2016, and April 2017). The list of species was complemented with records of species previously reported for LTRS. Results: The updated list comprises up to 27 species of sea slugs. The most representative groups are: Order Cephalaspidea with nine species, Aplysiida with seven species and Superorder Sacoglossa with seven species. The distribution of Cyerce habanensis and Elysia cornigera extends to the north of Veracruz and Lobiger souverbii constitutes a new record for the Southwestern Gulf of Mexico Reef Corridor. Conclusions: Our study favorably increases the knowledge of sea slugs for the LTRS. This information could support strategies of conservation and protection for the management plans of this protect natural area.

Abstract Disarticulated shells of three bivalve mollusk species (Anomalocardia brasiliana, Codakia orbicularis, and Divaricella quadrisulcata) were experimentally tested in laboratory flumes to determine the threshold of motion and final orientation of the valves. A total of 150 current flow experiments were conducted on single shells resting on a fixed sand bed. This study demonstrated that shells in the convex-up position are more resistant to flow when the umbo is pointing downstream rather than upstream. Moreover, species with higher frontal areas were more likely to be entrained at lower flow velocities. Results of dimensionless shear stress exhibited values far below the threshold of grains movement for beds of uniform roughness (Shields curve). It was observed that circular shells in convex-up positions were mostly orientated with the umbo pointing downstream. Conversely, elliptical shells in convex-up position tended to align their longer axis parallel to the flow with the posterior side of the valve pointing downstream. These results are not only directly applicable in interpretations of incipient shell motions and in paleocurrent analyses from field and sample data, but also support construction of accurate geological models. Anomalocardia brasiliana orbicularis quadrisulcata valves 15 bed convexup convex up upstream Moreover velocities Shields curve. curve . curve) Conversely data models 1

To contribute to reinforcing the idea that sites not associated with Protected Natural Areas have high ecological value, we carried out this research in a river located in the middle of an industrial park. Over 1.4 km of the Rio Hondo, there were defined ten sampling plots of 10 x 10 m to evaluate trees and shrubs (height and diameter at breast height) and ten nested squares of 1 x 1 m for herbaceous (we only recorded the presented species). Each specimen was taxonomically determined and its abundance was established (very common, common, frequent, scarce, rare, very rare). Twenty-three plant species were recorded, the best represented family was Poaceae. A total of 105 individuals were counted, with an average height of 7.3 m; the median diameter at breast height was of 29.5 cm. The RÃo Hondo maintains typical elements of riparian vegetation, such as Alnus acuminata and Salix humboldtiana. Although, it is located in an industrial park and in a highly impacted area, the RÃo Hondo maintains a plant structure of a high ecological value.

Para contribuir a reforzar la idea de que sitios asociados a zonas industriales también poseen altos valores ecológicos, desarrollamos esta investigación en un rÃo enclavado en un parque industrial. Diez sitios de muestreo de 10 x 10 m para evaluar los árboles y arbustos (altura y diámetro a la altura del pecho); y diez cuadros anidados de 1 x 1 m para la herbáceas (sólo se registraron las especies presentes) fueron definidos sobre 1.4 km del RÃo Hondo. Cada ejemplar se determinó taxonómicamente y se estableció su abundancia (muy común, común, frecuente, escasa, rara y muy rara). Se registraron 23 especies vegetales, la familia mejor representada fue Poaceae. Se contabilizaron 105 individuos, con una altura promedio de 7.3 m; la mediana del diámetro a la altura del pecho fue de 29.5 cm. El RÃo Hondo mantiene elementos propios de vegetación ribereña como Alnus acuminata y Salix humboldtiana; asimismo, a pesar de ubicarse dentro de un parque industrial y en una zona altamente impactada, el RÃo Hondo mantiene una estructura vegetal con alto valor ecológico.

Resumen Utilizando el método de inventarios perpetuos con factor de ajuste de Almon (1999), se hace una propuesta de estimación de acervos de capital, tanto público como privado, en México a nivel estatal para el periodo de 2004-2018. Se utilizaron datos de formación bruta de capital fijo estatal, una tasa de depreciación promedio del 9.7% tomada del INEGI -cuentas nacionales; consumo de capital fijo- y se calcularon ponderadores para cada año. El resultado que se obtiene es una serie de datos congruente con las fluctuaciones económicas, pues sigue la tendencia de la formación bruta de capital fijo real. Además, resuelve el problema de estimación inherente al método de inventarios perpetuos.

Abstract Using the perpetual inventories method with adjustment factor of Almon (1999), a proposal is made of estimating capital stocks, both public and private, in Mexico at the subnational level for the period 2004-2018. Gross state fixed capital formation data, average depreciation rate of 9.7% from INEGI -national counts; fixed capital consumption- were used and weights were calculated for each year. As a result, a series of data consistent with economic fluctuations is obtained, as it follows the trend of gross real fixed capital formation. It also solves the estimation problem inherent in the perpetual inventory method.

ABSTRACT Introduction: Processes such as mutagenesis, carcinogenesis and teratogenesis are the product of the interaction of agents of endogenous and exogenous origin that interact with the DNA molecule in a chronic way producing ruptures in the double helix, and in complete chromosomes resulting in genomic instability. The oxidative stress to which the cells are subjected when reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed, which may come from radicals produced as a result of diabetes or in initial stages of chronic kidney disease or in response to inflammatory processes in advanced stages of these pathologies, act as endogenous genotoxic agents. Objectives: This research aimed to determine the basal damage in the DNA molecule of hemodialyzed diabetic patients, through the Comet assay, as a bioindicator of genomic instability, during six months of treatment. Materials and methods: For this research, a prospective longitudinal cohort study was proposed to compare the different levels of genetic damage before and during the first six of hemodialysis treatment. Baseline damage was evaluated with the comet test or single cell electrophoresis, in venous blood samples from patients diagnosed with Type II Diabetes as a negative control and in diabetic patients with chronic kidney disease before starting dialysis treatment and then during treatment. Results: A significant increase in basal and oxidative damage was observed in the genetic material of diabetic patients with chronic kidney disease, compared to negative controls (p< 0.005) and it was also observed that cell damage increases with hemodialysis treatment (p<0.005). The t-Student test was used for independent and paired samples. Conclusion: The results obtained in this research allow us to conclude that oxidative stress has a genotoxic effect and that the level of genetic damage is a good bioindicator of the progression of chronic kidney disease and that hemodialysis induces an increase in damage at the level of the genetic material, increasing the risk of carcinogenesis.

RESUMEN Introducción: Procesos como la mutagénesis, la carcinogénesis y la teratogénesis son producto de la interacción de agentes de origen endógeno como exógeno que interactúan con la molécula de ADN en forma crónica produciendo rupturas en la doble hélice, y en cromosomas completos resultando en la inestabilidad genómica. El estrés oxidativo al que se encuentran sometidas las células al formarse las especies reactivas de oxígeno (ROS) y también las especies reactivas de nitrógeno (RNS), que pueden provenir de radicales producidos a consecuencia de la diabetes o en estados iniciales de la enfermedad renal crónica o como respuesta a procesos inflamatorios en estados avanzados de estas patologías, actúan como agentes genotóxicos endógenos. Objetivos: Esta investigación tuvo como objetivo determinar el daño basal en la molécula de ADN de pacientes diabéticos hemodializados, a través del ensayo del Cometa, como un bioindicador de inestabilidad genómica., durante seis meses de tratamiento. Materiales y métodos: Se planteó un estudio longitudinal prospectivo de cohorte para comparar los diferentes niveles de daño antes y durante los primeros seis del tratamiento de hemodiálisis. Se evaluó con el test del cometa o electroforesis de células individuales, el daño basal en muestras de sangre venosa de pacientes diagnosticados con Diabetes de tipo II como control negativo y en pacientes diabéticos con enfermedad renal crónica antes de iniciar el tratamiento de diálisis y luego durante el tratamiento. Se utilizó el test de t- Student para muestras independientes y emparejadas. Resultados: Se observó un aumento significativo de daño basal y oxidativo en el material genético de pacientes diabéticos con enfermedad renal crónica, comparados con los controles negativos (p< 0.005) y se observó, además, que el daño celular aumenta con el tratamiento de hemodiálisis (p<0.005). Conclusión: Los resultados obtenidos en esta investigación permiten concluir que el estrés oxidativo tiene un efecto genotóxico y que el nivel de daño genético es un buen bioindicador del avance de la enfermedad renal crónica y que la hemodiálisis induce a un aumento de daño a nivel del material genético, aumentando el riesgo de carcinogénesis.

Resumo: Descrevemos de forma resumida resultados selecionados do nosso projeto temático com foco na biodiversidade da Floresta Atlântica (“AF BIOTA”), que foi financiado pelo BIOTA FAPESP e pelo programa “Dimensions of Biodiversity” da “U.S. National Science Foundation” e “National Aeronautics and Space Administration” (NASA). Devido à sua megabiodiversidade (que inclui várias espécies endêmicas), e por restar menos de 16% da vegetação original, a Floresta Atlântica (FA) é uma das cinco áreas mais importantes para a biodiversidade do planeta (“biodiversity hotspot”). Reunimos especialistas de diversas disciplinas (biologia, geologia, engenharia) visando compreender como essa megabiodiversidade evoluiu ao longo do tempo e fornecer informações científicas para a sua conservação. Dentre os resultados obtidos, nós formamos 18 mestres e 26 doutores, publicamos mais de 400 artigos científicos que aumentaram o conhecimento sobre a diversidade biológica e climática da FA e sua dinâmica ao longo do tempo, desenvolvemos novos métodos analíticos, produzimos material de divulgação científica e fornecemos dados para desenvolver políticas públicas de conservação da biodiversidade.

Abstract: We briefly describe selected results from our thematic project focused on the biodiversity of the Atlantic Forest (“AF BIOTA”), which was jointly funded by FAPESP’s BIOTA Program, the U.S. National Science Foundation Dimensions of Biodiversity Program, and the National Aeronautics and Space Administration (NASA). As one of the five most important hotspots of biodiversity in the world, the Atlantic Forest (AF) holds less than 16% of its vegetation cover, yet, amongst the hotspots, it still harbors one of the highest numbers of species, including endemics. By gathering specialists across multiple disciplines (biology, geology, engineering), we aimed to understand how this megabiodiversity was built through time, informing biodiversity science and conservation. Among the results, we trained 18 Master’s and 26 Ph.D. students, published more than 400 peer-reviewed papers that improved our knowledge about the forest’s biologic and climatic diversity and dynamics through time, developed new analytical methods, produced outreach videos and articles, and provided data to help define biodiversity conservation policies.

Resumo A proliferação das comunidades virtuais aliada à recente popularização dos meios de hospedagem colaborativa no setor turístico oportunizou a consumação de experiências insólitas de hospitalidade que demandam alto grau de confiança dos viajantes. Este artigo buscou compreender como as revisões de hóspedes auxiliam na transmissão da confiança a outros usuários para novas reservas de estadias na plataforma Airbnb. Mediante abordagem qualitativa de cunho exploratório, empreendeu-se uma análise de conteúdo em 210 avaliações de hóspedes que viajaram para Fortaleza/CE, publicadas entre 2018 e 2019. O estudo inovou ao amparar-se nos determinantes da credibilidade de uma revisão on-line retratados na literatura acadêmica internacional (relevância, precisão, abrangência e atualidade) para a seleção dos comentários. Os resultados revelaram que, quanto ao anfitrião, os principais argumentos usados para propagar confiança foram a receptividade e a solicitude. Em relação ao espaço, destacaram-se localização, conforto e limpeza. No tocante as consequências da experiência, firmaram-se a propensão ao retorno e a recomendação. Observou-se também uma relação de convergência dos argumentos identificados com o sentimento de familiaridade e estar em casa que muitos hóspedes relataram. Surpreendentemente, a fidedignidade do espaço aos anúncios e a segurança do lugar – aspectos associados ao risco – não emergiram expressivamente nos discursos dos viajantes.

Abstract The increase of virtual communities together with the recent popularization of collabo-rative hosting facilities in the tourism sector has enabled the consumption of non-traditional hospitality experiences that demand a high degree of travelers’ confidence. This article sought to understand how guest reviews help in transmitting trust to other on the Airbnb platform. Based on a qualitative research, a content analysis was un-dertaken into 210 guest reviews, published between 2018 and 2019, who traveled to Fortaleza/CE. The study innovates by focusing on the determinants of the credibility of an online review based on international literature (relevance, accuracy, complete-ness, and timeliness) for the selection of comments. Results revealed that, regarding the host, the main arguments used to promote trust were receptivity and solicitude. In relation to the space, location, comfort, and cleanliness stood out. Regarding the consequences of the experience, the propensity to return and recommendation were established. It was also observed a relationship of convergence of the arguments identified with the feeling of familiarity and being at home that many guests reported. Surprisingly, the trustworthy of space to ads and the security of the place – aspects associated with risk – did not emerge significantly in the speeches of travelers.

Resumen La proliferación de comunidades virtuales junto con la reciente popularización de las instalaciones de alojamiento colaborativo en el sector turístico ha permitido la consumación de experiencias de hospitalidad inusuales que exigen un alto grado de confianza de los viajeros. Este artículo trató de entender cómo las opiniones de los huéspedes ayudan a transmitir confianza a otros usuarios para nuevas reservas de estancias en la plataforma Airbnb. A través de un enfoque cualitativo de carácter exploratorio, se llevó a cabo un análisis de contenido en 210 revisiones de los huéspedes que viajaron a Fortaleza /CE, publicados entre 2018 y 2019. El estudio innovó centrándose en los determinantes de la credibilidad de una revisión en línea retratada en la literatura académica internacional (relevancia, exactitud, alcance y puntualidad) para la selección de comentarios. Los resultados revelaron que, con respecto al anfitrión, los principales argumentos utilizados para propagar la confianza eran la receptividad y la solicitud. En relación con el espacio, la ubicación, la comodidad y la limpieza se destacó. En cuanto a la consecuencias con la experiencia, se estableció la propensión al retorno y la recomendación. También se observó una relación de convergencia de los argumentos identificados con el sentimiento de familiaridad y estar en casa que muchos huéspedes informaron. Sorprendentemente, la fiabilidad del espacio a los anuncios y la seguridad del lugar – aspectos asociados con el riesgo – no surgieron significativamente en los discursos de los viajeros.

ABSTRACT Overactive bladder is a symptom complex consisting of bothersome storage urinary symptoms that is highly prevalent among both sexes and has a significant impact on quality of life. Various antimuscarinic agents and the beta-3 agonists mirabegron and vibegron are currently available for the treatment of OAB. Each drug has specific pharmacologic properties, dosing schedule and tolerability profile, making it essential to individualize the medical treatment for the patient's characteristics and expectations. In this manuscript, we review the most important factors involved in the contemporary pharmacological treatment of OAB.

Abstract This article analyzes the evolution of gross fixed capital formation in Mexico, and especially the interactions between private and public ones, and its relationship with the rate of economic growth in the 1960-2018 period. The work is organized in the following way. The introduction presents the purpose of the study in detail. Section I examines the theoretical discussion around public and private investment and their complimentary or competitive interrelationships. The following section presents the methodology used here for the empirical analysis, it explains key aspects in the construction of the data series that were carried out, always based on official sources. As explained there, the empirical analysis covered two complementary validation efforts: The first is based on cash flow accounting models to calculate “Keynesian” multipliers of investment over the gross domestic product (GDP), for selected sub-periods: 1) the state-led industrialization stage (1960-1981), and 2) the stage of market reforms already in full operation (1988-2018). The second effort resorted to modern time series econometrics-it goes without say that are based on the same data from the first exercise-to balance the interrelationships between private and public investment in the growth trajectory of the Mexican economy. The conclusions are presented in the last section, which, in our opinion, provide relevant inputs to better understand the interaction of private and public investment in Mexico’s economic growth process, and with this, perhaps, to better design an agenda development to get the country out of the slow-growth trap in which it has been plunged for decades.

Resumen El presente artículo analiza la evolución de la formación bruta de capital fijo en México, en especial, las interacciones entre la privada y la pública, y su relación con el ritmo de crecimiento económico en el periodo de 1960 a 2018. El trabajo está organizado de la siguiente forma. La introducción presenta en detalle el propósito del estudio. La sección I examina la discusión teórica en torno a la inversión pública y la privada, así como sus interrelaciones complementarias o competitivas. La siguiente sección presenta la metodología seguida para el análisis empírico; explica aspectos clave en la construcción de las series de datos que se realizaron, siempre con base en fuentes oficiales. Como ahí se explica, el análisis empírico cubrió dos esfuerzos complementarios de validación: el primero se basa en modelos contables de flujos de fondos para el cálculo de multiplicadores keynesianos de la inversión sobre el producto interno bruto (PIB), para subperiodos seleccionados: 1) la etapa de industrialización liderada por el Estado (1960-1981) y 2) la de reformas de mercado ya en plena operación (1988-2018). El segundo esfuerzo recurrió a la econometría moderna de series de tiempo -sobra decir que se basan en los mismos datos del primer ejercicio- a fin de conmensurar las interrelaciones entre la inversión privada y la pública en la trayectoria de crecimiento de la economía mexicana. Las conclusiones se presentan en la última sección, mismas que, a nuestro juicio, aportan insumos relevantes para entender mejor la interacción entre la inversión privada y la pública en el proceso de crecimiento económico de México, y con ello, quizá, para diseñar mejor una agenda de desarrollo encaminada a sacar al país de la trampa de lento crecimiento en la que lleva sumido décadas.