ABSTRACT Objective Sulfonylureas have been used to improve performance in strength sports. However, this hypothetical effect has not been proven. We examined the ergogenic acute effect of gliclazide on resistance training performance and muscle recovery. Subjects and methods We conducted a double-blind, randomized, crossover pilot study with 10 healthy resistance-trained adults (29.3 ± 4.4 years), nonusers of anabolic steroids. The participants were randomized to two exercise sessions. In the first session, five participants received placebo and the other five received gliclazide modified release, both administered 8 hours before the session. Session two was performed in a crossover fashion a week later. The volume load was calculated as the maximum number of repetitions of four sets multiplied by load (65% 1-RM). Blood samples were collected before and after exercise, as well as 24 hours and 48 hours after exercise for measurement of creatine kinase (CK-MM) and lactate dehydrogenase (LDH) activity. Blood glucose was measured with a glucometer before, during, and after the exercise sessions. Results Gliclazide did not enhance volume load for bench press (placebo: 2,698.0 ± 923.0 kg; gliclazide: 2,675.0 ± 1,088.0 kg; p = 0.073) or leg press (placebo: 10,866.0 ± 2,671.0 kg; gliclazide: 10,817.0 ± 2,888.0 kg; p = 0.135). However, CK-MM (-27.7%; p = 0.034) and LDH (-21.1%; p = 0.021) activities were decreased with gliclazide 48 hours after exercise. There was also a decrease in blood glucose in the gliclazide compared with the placebo session (p = 0.018). Conclusion Gliclazide did not enhance performance in a single resistance training session, but promoted faster muscle recovery. The decrease in blood glucose post-exercise with gliclazide was an undesirable effect that could lead to long-term glucose metabolism disorders. Registered in ClinicalTrials.gov under number NCT04443777. sports However proven recovery doubleblind, doubleblind double blind, blind double-blind 1 resistancetrained trained 29.3 293 29 3 (29. 44 4 4. years, years , years) steroids sessions release later 65% 65 (65 1RM. 1RM RM . 1-RM) 2 CKMM CK MM (CK-MM (LDH activity during (placebo 26980 698 0 2,698. 9230 923 923. kg 26750 675 2,675. 10880 088 1,088. 0.073 0073 073 108660 866 10,866. 26710 671 2,671. 108170 817 10,817. 28880 888 2,888. 0.135. 0135 0.135 135 0.135) 27.7% 277 27 7 (-27.7% 0.034 0034 034 21.1% 211 21 (-21.1% 0.021 0021 021 0.018. 0018 0.018 018 0.018) postexercise post longterm long term disorders ClinicalTrialsgov ClinicalTrials gov NCT04443777 NCT 29. (29 6 (6 1-RM 2698 69 2,698 92 2675 67 2,675 1088 08 1,088 0.07 007 07 10866 86 10,866 2671 2,671 10817 81 10,817 2888 88 2,888 013 0.13 13 27.7 (-27.7 0.03 003 03 21.1 (-21.1 0.02 002 02 001 0.01 01 NCT0444377 (2 ( 269 2,69 9 267 2,67 108 1,08 0.0 00 1086 10,86 1081 10,81 288 2,88 0.1 27. (-27. 21. (-21. NCT044437 26 2,6 1,0 0. 10,8 28 2,8 (-27 (-21 NCT04443 2, 1, 10, (-2 NCT0444 (- NCT044 NCT04 NCT0

Introduction: Whole-body vibration training (WBVT) has been shown to be an extremely useful tool for increasing muscle mass, bone tissue, muscle power, flexibility, and strength, among others. However, to date, there are few studies on the effects of WBVT on energy metabolism and whether this tool could be able to enhance weight loss in addition to a nutritional plan and/or exercise. Objective: The aim of this review is to analyse the most recent studies on vibration training in order to determine whether this method constitutes a reliable complement to programs aimed at weight loss. Methods: An updated literature search was conducted using PubMed, SciELO and SPORTDiscus. In addition, a detailed search was also performed from references given in selected studies. Results: WBVT appears to be associated with three pathways involved in weight loss: inhibition of adipogenesis and reduction of fat mass, increased energy expenditure, and increase in muscle mass. After analysing the literature, none of the results for the proposed pathways are consistent, and indeed are often contradictory. Conclusion: Further in-depth research is required on this subject. However, WBVT would appear to be a safe method, and may possibly yield benefits, mainly as regards muscle mass, which in turn might promote weight loss when combined with a nutritional plan and a traditional exercise program.

Introducción: El entrenamiento de vibraciones de cuerpo completo (EVCC) ha demostrado ser de gran utilidad para aumentar la masa muscular, el tejido óseo, la potencia muscular, la flexibilidad, y la fuerza, entre otros. No obstante, hasta la fecha es escasa la literatura respecto a sus efectos sobre el metabolismo energético y si esta herramienta podría ser capaz de potenciar la pérdida de peso como complemento a un programa nutricional y/o de ejercicio físico. Objetivo: El objetivo de la presente revisión es analizar los últimos estudios sobre el EVCC con la finalidad de determinar si puede ser un método fiable para complementar los programas orientados a la reducción del peso corporal. Métodos: Se realizó una búsqueda bibliográfica en Pubmed, Scielo y SPORTDiscus, así como una búsqueda manual entre las referencias de los estudios seleccionados. Resultados: El EVCC parece estar vinculado a tres vías relacionadas con la reducción del peso corporal: inhibición de la adipogénesis y reducción de la masa grasa, aumento del gasto energético y aumento de la masa muscular. Tras analizar la literatura, ninguna de las vías propuestas es consistente, y en muchas ocasiones los resultados son contradictorios. Conclusión: Se concluye que es necesario profundizar sobre esta línea de investigación. No obstante, el EVCC parece ser un método seguro y posiblemente tendría beneficios, principalmente sobre la masa muscular, lo que podría promover la pérdida de peso si se combina con un plan nutricional y un programa de ejercicio tradicional.