ABSTRACT Objective: The objective of the study was to assess the association of anthropometric measurements with endothelial function and arterial stiffness of eutrophic individuals and with overweight. Subjects and methods: A cross-sectional study was carried out with individuals with body mass index (BMI) between 18.5 kg/m² and < 30 kg/m², low to intermediate global cardiovascular risk scores, and aged ≥ 18 and < 60 years. We assessed the sociodemographic data, anthropometric variables (body weight, height, circumferences of the waist [WC], neck [NC], hip [HC], sagittal abdominal diameter [SAD], [BMI], waist-to-hip ratio [WHR], and waist-to-height ratio [WHtR]), biochemical parameters (lipid profile and nitric oxide), endothelial function (flow-mediated dilation [FMD], by ultrasound), and arterial stiffness (pulse wave velocity [PWV] and the amplification index [AIx@75] by oscillometry). Thirty-six individuals were included, 18 eutrophic and 18 with overweight, with a mean age of 37.5 ± 10.2 years, mostly at low cardiovascular risk (86.1%), female (80.6%), single (52.8%), employed with formal contracts (44.4%), and with over twelve years of education (88.9%). Results: The PWV presented positive and moderate correlation with the WC (r = 0.584; P = 0.001), WHR (r = 0.513; P = 0.001), and WHtR (r = 0.590; P = 0.001), and positive and low correlation with the NC (r = 0.372; P = 0.013) and SAD (r = 0.356; P = 0.033). Moreover, no anthropometric parameter presented a correlation with the AIx@75 or the FMD percentage in the total sample. Conclusion: Our findings show that in eutrophic individuals and with overweight the WC, WHR, WHtR, SAD, and NC were positively correlated with the PWV but not to the endothelial function in the overall sample. These are hypothesis-generating findings and they should be replicated in other studies. Objective methods crosssectional cross sectional BMI (BMI 185 5 18. kgm² kgm kg m² m kg/m 3 scores 1 6 data weight height , [WC] NC, [NC] HC, HC [HC] [SAD] BMI, [BMI] waisttohip [WHR] waisttoheight [WHtR]) lipid oxide, oxide oxide) flowmediated flow mediated FMD, [FMD] ultrasound, ultrasound ultrasound) pulse [PWV AIx75 AIx 75 [AIx@75 oscillometry. oscillometry . oscillometry) Thirtysix Thirty six included 375 37 37. 102 10 2 10. 86.1%, 861 86.1% 86 (86.1%) 80.6%, 806 80.6% 80 (80.6%) 52.8%, 528 52.8% 52 8 (52.8%) 44.4%, 444 44.4% 44 4 (44.4%) 88.9%. 889 88.9% 88 9 (88.9%) Results r 0.584 0584 0 584 0.001, 0001 0.001 001 0.001) 0.513 0513 513 0.590 0590 590 0.372 0372 372 0.013 0013 013 0.356 0356 356 0.033. 0033 0.033 033 0.033) Moreover AIx@7 sample Conclusion hypothesisgenerating hypothesis generating studies [WC [NC [HC [SAD [BMI [WHR [WHtR] [FMD AIx7 7 [AIx@7 86.1 (86.1% 80.6 (80.6% 52.8 (52.8% 44.4 (44.4% 88.9 (88.9% 0.58 058 58 000 0.00 00 0.51 051 51 0.59 059 59 0.37 037 0.01 01 0.35 035 35 003 0.03 03 AIx@ [WHtR [AIx@ 86. (86.1 80. (80.6 52. (52.8 44. (44.4 88. (88.9 0.5 05 0.0 0.3 [AIx (86. (80. (52. (44. (88. 0. (86 (80 (52 (44 (88 (8 (5 (4 (

ABSTRACT Introduction: Stroke remains a major complication of cardiac surgery. Despite all efforts, the incidence of postoperative stroke remains as high as 6%. We aimed to investigate risk factors for ischemic stroke in a contemporary cohort of patients undergoing cardiac surgery. Methods: This is a retrospective cohort study of 678 consecutive adult patients who underwent cardiac surgery requiring cardiopulmonary bypass in a tertiary hospital in Brazil between July 1, 2011, and December 31, 2018. The primary outcome was the rate of early (perioperative and seven-day postoperative) stroke, defined as the occurrence of the outcome during the index admission. We developed a predictive model of stroke using the Poisson regression analysis with robust variance. Results: Postoperative stroke occurred in 24 patients (3.5%), 23 (3.3%) were ischemic, and 21 (3.0%) were diagnosed in the first 72 hours after surgical procedure. After multivariate analysis, the following factors were significantly associated with stroke: previous stroke/transient ischemic attack (relative risk [RR]=2.75; 95% confidence interval [CI], 1.11-6.82), carotid artery disease (RR=4.0; 95% CI, 1.43-11.0), previous atrial fibrillation (RR=3.26, 95% CI, 1.31-8.1), and postoperative platelets > 200,000/mm3 (RR=2.26; 95% CI, 1.01-5.1). Conclusion: We developed a contemporary model to determine risk predictors for stroke after cardiac surgery. This model may help clinicians to identify patients at risk and could be useful in clinical practice. Introduction efforts 6 6% Methods 67 1 2011 31 2018 perioperative sevenday seven day admission variance Results 2 3.5%, 35 3.5% , 3 5 (3.5%) 3.3% 33 (3.3% 3.0% 30 0 (3.0% 7 procedure stroketransient transient relative RR=2.75 RR275 RR =2.75 75 [RR]=2.75 95 CI [CI] 1.116.82, 111682 1.11 6.82 11 82 1.11-6.82) RR=4.0 RR40 4 (RR=4.0 1.4311.0, 143110 1.43 11.0 43 1.43-11.0) RR=3.26, RR326 26 (RR=3.26 1.318.1, 13181 1.31 8.1 8 1.31-8.1) 200000mm3 mm 200 000 mm3 200,000/mm RR=2.26 RR226 (RR=2.26 1.015.1. 10151 1.01 5.1 . 01 1.01-5.1) Conclusion practice 201 3.5 (3.5% 3.3 (3.3 3.0 (3.0 RR=2.7 RR27 275 =2.7 [RR]=2.7 9 [CI 116 1.116.82 11168 111 1.1 682 6.8 1.11-6.82 RR=4. RR4 (RR=4. 4311 1.4311.0 14311 143 1.4 110 11. 1.43-11.0 RR=3.26 RR32 (RR=3.2 318 1.318.1 1318 131 1.3 81 8. 1.31-8.1 200000mm 20 00 RR=2.2 RR22 (RR=2.2 015 1.015.1 1015 101 1.0 51 5. 1.01-5.1 3. (3.5 (3. RR=2. RR2 27 =2. [RR]=2. 1.116.8 1116 1. 68 6. 1.11-6.8 RR=4 (RR=4 431 1.4311. 1431 14 1.43-11. RR=3.2 RR3 (RR=3. 1.318. 13 1.31-8. (RR=2. 1.015. 10 1.01-5. (3 RR=2 =2 [RR]=2 1.116. 1.11-6. RR= (RR= 1.4311 1.43-11 RR=3. (RR=3 1.318 1.31-8 (RR=2 1.015 1.01-5 ( = [RR]= 1.116 1.11-6 (RR 1.431 1.43-1 RR=3 1.31- 1.01- [RR] 1.11- 1.43- [RR

Resumo Nosso estudo descreve um caso fatal de flegmasia cerúlea dolens e trombose venosa maciça em um paciente usando regularmente rivaroxabana para o tratamento de trombose de seio venoso cerebral. A investigação laboratorial foi positiva para o anticoagulante lúpico. A evolução única do caso aumenta a possibilidade de uma síndrome de hipercoagulabilidade adquirida, bem como a positividade para o anticoagulante lúpico. Destacamos o fato de que o teste recomendado como primeira linha para o diagnóstico de anticoagulante lúpico (veneno de víbora de Russel diluído) é o mais afetado pela rivaroxabana, levando a uma alta prevalência de resultados falso-positivos. Também discutimos os potenciais diagnósticos para o presente caso e revisamos o estado da arte atual dos novos agentes de anticoagulação oral usados nessa situação incomum. Até o presente momento, não há recomendações para o uso de tais agentes como primeira opção na trombose de seios venosos cerebrais ou nas síndromes de hipercoagulação.

Abstract Our study describes a fatal case of phlegmasia cerulea dolens and massive venous thrombosis in a patient taking rivaroxaban regularly to treat cerebral venous sinus thrombosis. Blood tests samples were positive for lupus anticoagulant. The unique evolution of the case, as well as the positivity for lupus anticoagulant, raises the possibility of an acquired hypercoagulation syndrome. We highlight the fact that the test recommended as the first line for lupus anticoagulant diagnosis (dilute Russell viper venom time) is the most affected by rivaroxaban, leading to a high prevalence of false-positive results. We also discuss potential diagnoses for the current case and review the current state-of-the-art of use of the novel oral anticoagulation agents in this unusual situation. So far, there are no recommendations to use such agents as first options in cerebral venous sinus thrombosis or in hypercoagulation syndromes.

Abstract INTRODUCTION: Sporotrichosis is a subcutaneous fungal infection with a worldwide distribution and higher incidence in tropical and subtropical areas, such as the Brazilian territory, where it has been standing out due to its frequent epidemics. Thus, the present study aimed to evaluate the prevalence of sporotrichosis and profile the affected patients at a university teaching hospital in the central region of Rio Grande do Sul, Brazil. METHODS: This study was a case series of patients diagnosed with Sporothrix spp. from January 2006 to December 2015 by microscopic examination or fungal isolates. Medical records were reviewed for epidemiological data. RESULTS: Forty-three cases of sporotrichosis were diagnosed through the period. The sample comprised predominantly young male adults and rural workers. The most common disease type was lymphocutaneous (51%), followed by fixed cutaneous form (32.5%). The predominant location was the upper limbs (70%), followed by the lower limbs (16%). A significant association was observed between the lymphocutaneous form and upper limb location and between the fixed cutaneous form and lower limb location (p = 0.019). Potassium iodine and itraconazole were the most common treatments. CONCLUSIONS: This study will help update the epidemiological situation of sporotrichosis in the central region of the state of Rio Grande do Sul, Brazil, over the last decade.

Linfoma não-Hodgkin sistêmico pode afetar o miocárdio, particularmente em pacientes imunocomprometidos. Quando presentes, sinais e sintomas são geralmente inespecíficos, tornando o diagnóstico de envolvimento cardíaco muito difícil antes da autópsia. Arritmias ventriculares também são pouco usuais nesse cenário. Descrevemos um caso de linfoma não-Hodgkin miocárdico secundário, que se apresentou com taquicardia ventricular monomórfica sustentada e espessamento do septo interventricular basal. Completa remissão das lesões miocárdicas foi observada após o término da quimioterapia de segunda linha, sem recorrências posteriores de arritmias em oito meses.

Systemic non-Hodgkin's lymphoma can affect the myocardium, particularly in immunocompromised patients. When present, symptoms and signs are usually nonspecific, making the diagnosis of cardiac involvement very difficult before an autopsy. Ventricular arrhythmias are also unusual in this setting. We describe a case of secondary myocardial non-Hodgkin's lymphoma presenting with sustained monomorphic ventricular tachycardia and thickening of the basal interventricular septum. Complete remission of myocardial lesions was observed after completion of second-line chemotherapy treatment, without further recurrences of arrhythmias in eight months.

Linfoma no Hodgkin sistémico puede afectar el miocardio, particularmente en pacientes inmunocomprometidos. Cuando están presentes, señales y síntomas son generalmente inespecíficos, volviendo el diagnóstico de compromiso cardíaco muy difícil antes de la autopsia. Arritmias ventriculares también son poco usuales en ese escenario. Describimos un caso de linfoma no Hodgkin miocárdico secundario, que se presentó con taquicardia ventricular monomórfica sustentada y engrosamiento del septo interventricular basal. Completa remisión de las lesiones miocárdicas fue observada después del término de la quimioterapia de segunda línea, sin recurrencias posteriores de arritmias en ocho meses.

O ensino médico é extremamente importante na determinação da qualidade técnica dos futuros profissionais. Embora o Brasil apresente legislação específica sobre o tema, observamos discrepâncias no processo de aprendizado, o que, muitas vezes, compromete a formação dos futuros médicos. Além disso, métodos de ensino tradicionais, baseados fundamentalmente no diagnóstico de problemas, são ainda praticados em várias faculdades. Estes métodos relegam preceitos educacionais e, muitas vezes, colocam os estudantes em papel secundário. Nessa perspectiva, apresentamos um promissor método de ensino médico chamado Preceptoria em um Minuto (One-Minute Preceptor), salientando seu papel voltado ao profissional em formação. Destacamos também a importância deste método por permitir o ensino em tempo relativamente limitado, frente à crescente demanda por atendimentos

Medical teaching is extremely important for determining the quality of future professionals. Although Brazil has specific legislation on the subject, discrepancies have been observed in the learning process, often jeopardizing the training of future physicians. Furthermore, traditional teaching methods, based mainly on the diagnosis of problems, are still practiced in various medical schools. These methods ignore fundamental rules of education and relegate students to a secondary role. From this perspective, we present a promising method for medical education called the One-Minute Preceptor, emphasizing its role for in-training medical professionals. We also emphasize its importance for teaching in a time-limited scenario, due to the growing demand for care