RESUMO Introdução: Metodologias de ensino tradicionais, baseadas em aulas expositivas, têm sido usadas como padrão nas escolas médicas. Nas últimas décadas, têm ocorrido mudanças na educação médica no sentido de adotar métodos que encorajem a participação ativa dos alunos. Foi provado que as metodologias ativas aumentam o engajamento e isso foi particularmente necessário durante a pandemia da COVID-19, quando as metodologias ativas foram cruciais para aumentar a participação dos estudantes nas aulas virtuais. Objetivo: Este estudo objetivou medir a satisfação e o nível de participação dos alunos com aulas virtuais baseadas em metodologias ativas durante a pandemia da COVID-19. Método: Foram compilados dados de pesquisa anônima respondida por estudantes brasileiros do quarto ano de Medicina de uma universidade pública federal que cursaram a disciplina de pediatria durante um período de 18 meses. As metodologias usadas foram sala de aula invertida e aprendizado baseado em casos clínicos. Resultado: Participaram desta pesquisa 121 estudantes. O nível de satisfação com a metodologia foi alto (53% = muito satisfeito; 39% = satisfeito; 6% = indiferente; 2% = insatisfeito). A maioria dos alunos (70%) respondeu preferir ter aulas com as metodologias ativas empregadas, em comparação com aulas expositivas (16% preferem aulas expositivas; 14% são indiferentes). A adesão à leitura dos textos (sala de aula invertida) foi boa: 81% dos alunos leram entre 75% e 100% dos textos, e 19% leram entre 50% e 74% dos textos disponibilizados. Conclusão: A implementação de metodologias ativas na disciplina demonstrou ter sido bem-sucedida, considerando a participação e o nível de satisfação dos alunos. Introdução tradicionais médicas décadas COVID19, COVID19 COVID 19, 19 COVID-19 Objetivo COVID19. 19. Método 1 meses clínicos Resultado 12 53% 53 (53 satisfeito 39 6 indiferente 2 insatisfeito. insatisfeito . insatisfeito) 70% 70 (70% empregadas 16% 16 (16 14 indiferentes. indiferentes indiferentes) boa 81 75 100 50 74 disponibilizados Conclusão bemsucedida, bemsucedida bem sucedida, sucedida bem-sucedida COVID1 COVID-1 5 (5 3 7 (70 (1 8 10 COVID- ( (7

ABSTRACT Introduction: Traditional teaching, a lecturer-centered approach, has been the default methodology in medical schools. In the last decades, there has been a shift in health education towards methods that encourage the student’s active participation. It has been proved that active methodologies increase engagement, and this was particularly necessary during the COVID-19 pandemic, when active methodologies were crucial to raise student participation in online classes. Objective: This study aimed to measure student satisfaction and participation in online classes utilizing active learning methods during the COVID-19 pandemic. Methods: We gathered data from anonymous surveys completed by fourth-year medical students during 18 months of online classes of pediatrics at a public medical school in Brazil. Classes were taught using flipped classroom and case-based learning methodology. Results: One hundred and twenty-one students took part in this survey. Satisfaction level with case-based learning classes in the discipline was high (53% very satisfied; 39% satisfied; 6% neutral; 2% unsatisfied). Most of the students (70%) answered that, in general, they prefer CBL to expositive classes (16% prefer expositive classes; 14% are neutral). Reading compliance was good: 81% read 75-100% of the texts, and 19% read 50-74% of them. Conclusion: The implementation of the active learning curriculum for the discipline of pediatrics demonstrated to be successful considering the participation of the students and their satisfaction level. Introduction teaching lecturercentered lecturer centered approach schools decades s engagement COVID19 COVID 19 COVID-1 pandemic Objective Methods fourthyear fourth year 1 Brazil casebased case based Results twentyone twenty one survey 53% 53 (53 satisfied 39 6 neutral 2 unsatisfied. unsatisfied . unsatisfied) 70% 70 (70% general 16% 16 (16 14 neutral. neutral) good 81 75100% 75100 75 100% 100 75-100 texts 5074% 5074 50 74% 74 50-74 them Conclusion COVID1 COVID- 5 (5 3 7 (70 (1 8 7510 10 75-10 507 50-7 ( (7 751 75-1 50- 75-

Abstract Objective: This study aimed to describe the clinical and laboratory findings of patients diagnosed with pleural tuberculosis at two hospitals in southern Brazil. Methods: Patients aged < 18 years were evaluated retrospectively. The patients’ medical and epidemiological history, tuberculin skin test results, radiological and pathological findings, and pleural fluid analysis results were retrieved. Results: Ninety-two patients with pleural tuberculosis were identified. The mean age was 10.9 years old. Twenty-one percent were children aged six years or less. The most common symptoms were fever (88%), cough (72%), and chest pain (70%). Unilateral pleural effusion was observed in 96% of the cases. Lymphocyte predominance was found in 90% of the pleural fluid samples. The adenosine deaminase activity of the pleural fluid was greater than 40 U/L in 85% of patients. A diagnosis of community-acquired pneumonia with antibiotic prescriptions was observed in 76% of the study population. Conclusions: Tuberculosis etiology must be considered in unilateral pleural effusion in a child with contact with a case of tuberculosis. Pleural fluid biomarkers contribute to the diagnosis of pleural tuberculosis in children and adolescents.

SUMMARY Stress and burnout can result in errors, reduction in patient safety, and decreased productivity. They can cause absenteeism, depression, destructive behavior, alcohol, drug abuse, and even suicide. Several factors lead to professional stress, many of which are out of one’s control, thus making intervention impossible. Physicians often neglect their health and ignore stress and burnout. They often deny the existence of stress as a way of adapting to it, which is an ineffective method of coping with this problem that can lead to negative coping strategies. For managing stress and burnout, it is paramount to recognize situations/conditions that may trigger them, identify their signs, and invest in well-being strategies. In this article, well-being promotion is addressed with a focus on strategies that can be used at the individual level. Topics such as stress management and resilience should be valued in medical training and profession. As long as they form a part of the “hidden curriculum”, well-being will continue to be undervalued, when in fact it should be seen as fundamental to the health of professionals and patients.

RESUMO Objetivo: Avaliar a acurácia da determinação do nível de adenosina desaminase (ADA), da relação 2’-desoxiadenosina/ADA e da relação LDH/ADA no líquido pleural para o diagnóstico de tuberculose pleural (TP) em crianças e adolescentes. Métodos: Estudo transversal retrospectivo realizado em um hospital terciário em uma área de alta incidência de tuberculose entre 2001 e 2018. Todos os pacientes com determinação de ADA no líquido pleural e com diagnóstico confirmado de TP (TPc) ou de derrame parapneumônico (DPP) foram incluídos. Resultados: Os grupos TPc e DPP foram compostos por 25 e 68 indivíduos, respectivamente. Num ponto de corte de 40 U/L, a medida de ADA mostrou o seguinte: sensibilidade, 88%; especificidade, 31%; valor preditivo positivo (VPP), 32%; valor preditivo negativo (VPN), 88%; e acurácia geral, 46%. Os melhores pontos de corte foram ADA de 125 U/L, relação 2’-desoxiadenosina/ADA de 0,5 e relação LDH/ADA de 8,3, com ASC de 0,67, 0,75 e 0,82, respectivamente. A sensibilidade, especificidade, VPP, VPN e acurácia geral do ponto de corte de 125 U/L para ADA foram de 84%, 65%, 47%, 92% e 70%, respectivamente, em comparação com 79%, 79%, 59%, 91% e 79%, respectivamente, para o ponto de corte de 8,3 para a relação LDH/ADA. Ao alterar o ponto de corte da relação LDH/ADA para 3,0 a especificidade aumentou para 98%. Conclusões: O nível de ADA e a relação 2’-desoxiadenosina/ADA não são bons biomarcadores para o diagnóstico de PT em pacientes pediátricos. A determinação da relação LDH/ADA fornece a melhor acurácia geral para o diagnóstico de PT nesses pacientes.

ABSTRACT Objective: To evaluate the accuracy of determining the adenosine deaminase (ADA) level, the 2’-deoxyadenosine/ADA ratio, and the LDH/ADA ratio in pleural fluid for the diagnosis of pleural tuberculosis (PT) in children and adolescents. Methods: This was a retrospective cross-sectional study conducted at a tertiary hospital in a high-tuberculosis-incidence area, between 2001 and 2018. All patients with ADA in pleural fluid and a confirmed diagnosis of PT (cPT) or parapneumonic effusion (PPE) were included. Results: The cPT and PPE groups comprised 25 and 68 individuals, respectively. At a cutoff of 40 U/L, ADA measurement showed the following: sensitivity, 88%; specificity, 31%; positive predictive value (PPV), 32%; negative predictive value (NPV), 88%; and overall accuracy, 46%. The best cutoffs were an ADA level of 125 U/L, a 2’-deoxyadenosine/ADA ratio of 0.5, and an LDH/ADA ratio of 8.3, with AUC of 0.67, 0.75, and 0.82, respectively. The sensitivity, specificity, PPV, NPV, and overall accuracy of the 125 U/L ADA cutoff were 84%, 65%, 47%, 92%, and 70%, respectively, compared with 79%, 79%, 59%, 91%, and 79%, respectively, for the 8.3 LDH/ADA ratio cutoff. Changing the LDH/ADA ratio cutoff to 3.0 increased the specificity to 98%. Conclusions: The ADA level and the 2’-deoxyadenosine/ADA ratio are not good biomarkers for the diagnosis of PT in pediatric patients. Determination of the LDH/ADA ratio provides the best overall accuracy for the diagnosis of PT in such patients.