Abstract The study aimed to analyze the implementation of the School Health Program, identifying the actions developed, as well as factors that influence professional practice in daily life and strategies adopted by health professionals in view of the limitations found. The exploratory-descriptive case study method was used, with a qualitative approach. The study was carried out with 20 health professionals, program directors, in a family clinic in the city of Rio de Janeiro. Data were collected through semi-structured interviews, containing specific questions and open questions that discussed the topic. Data were analyzed using the Bardin technique. The results were grouped into categories and found the predominance of actions focused on biological and hygienist determinants, confirming the distance from the expanded concept of health in health promotion practices. The problems encountered refer to the scarcity of material and human resources, lack of training and continuing education, lack of planning and organizational infrastructure, violence in the territory, in addition to the pandemic period experienced during the study. On the other hand, the consolidation of the relationship between health and school emerged, demonstrating the presence of intersectoral dialogue and the incorporation of health actions in the school routine.

Resumo O objetivo do estudo foi analisar a implementação do Programa Saúde na Escola, identificando as ações desenvolvidas, bem como fatores que influenciam a prática profissional no cotidiano e estratégias adotadas pelos profissionais de saúde frente às limitações encontradas. Foi utilizado o método de estudo de caso do tipo exploratório-descritivo, com abordagem qualitativa. O estudo foi realizado com 20 profissionais de saúde, dirigentes do programa, em uma clínica da família no município do Rio de Janeiro. Os dados foram coletados por meio de entrevistas semiestruturadas, contendo perguntas específicas e perguntas abertas sobre o tema. Os dados foram analisados pela técnica de Bardin. Os resultados foram agrupados em categorias e constataram a predominância de ações com enfoque direcionado aos determinantes biológicos e higienistas, confirmando o distanciamento do conceito ampliado de saúde nas práticas de promoção da saúde. As problemáticas encontradas referem-se a escassez de recursos materiais e humanos, carência de capacitação e educação continuada, falta de planejamento e infraestrutura organizacional, violência no território, além do período pandêmico vivenciado durante o estudo. Por outro lado, emergiu a consolidação do relacionamento entre saúde e escola, demonstrando a presença do diálogo intersetorial e incorporação das ações de saúde no cotidiano escolar.

Abstract This study aimed to assess the influence of smoking on the subgingival metatranscriptomic profile of young patients affected by stage III/IV and generalized periodontal disease. Methodology In total, six young patients, both smokers and non-smokers (n=3/group), who were affected by periodontitis were chosen. The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines for case-control reporting were followed. Periodontal clinical measurements and subgingival biofilm samples were collected. RNA was extracted from the biofilm and sequenced via Illumina HiSeq. Differential expression analysis used Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and differentially expressed genes were identified using the Sleuth package in R, with a statistical cutoff of ≤0.05. Results This study found 3351 KEGGs in the subgingival biofilm of both groups. Smoking habits altered the functional behavior of subgingival biofilm, resulting in 304 differentially expressed KEGGs between groups. Moreover, seven pathways were modulated: glycan degradation, galactose metabolism, glycosaminoglycan degradation, oxidative phosphorylation, peptidoglycan biosynthesis, butanoate metabolism, and glycosphingolipid biosynthesis. Smoking also altered antibiotic resistance gene levels in subgingival biofilm by significantly overexpressing genes related to beta-lactamase, permeability, antibiotic efflux pumps, and antibiotic-resistant synthetases. Conclusion Due to the limitations of a small sample size, our data suggest that smoking may influence the functional behavior of subgingival biofilm, modifying pathways that negatively impact the behavior of subgingival biofilm, which may lead to a more virulent community. IIIIV III IV disease total nonsmokers non n=3/group, n3group ngroup n=3/group , n 3 group (n=3/group) chosen Strengthening Epidemiology casecontrol case control followed collected HiSeq KEGG (KEGG enrichment R 005 0 05 ≤0.05 335 groups 30 Moreover modulated degradation metabolism phosphorylation biosynthesis betalactamase, betalactamase beta lactamase, lactamase beta-lactamase permeability pumps antibioticresistant resistant synthetases size community (n=3/group 00 ≤0.0 33 ≤0. ≤0 ≤

Resumo O objetivo do estudo foi analisar a implementação do Programa Saúde na Escola, identificando as ações desenvolvidas, bem como fatores que influenciam a prática profissional no cotidiano e estratégias adotadas pelos profissionais de saúde frente às limitações encontradas. Foi utilizado o método de estudo de caso do tipo exploratório-descritivo, com abordagem qualitativa. O estudo foi realizado com 20 profissionais de saúde, dirigentes do programa, em uma clínica da família no município do Rio de Janeiro. Os dados foram coletados por meio de entrevistas semiestruturadas, contendo perguntas específicas e perguntas abertas sobre o tema. Os dados foram analisados pela técnica de Bardin. Os resultados foram agrupados em categorias e constataram a predominância de ações com enfoque direcionado aos determinantes biológicos e higienistas, confirmando o distanciamento do conceito ampliado de saúde nas práticas de promoção da saúde. As problemáticas encontradas referem-se a escassez de recursos materiais e humanos, carência de capacitação e educação continuada, falta de planejamento e infraestrutura organizacional, violência no território, além do período pandêmico vivenciado durante o estudo. Por outro lado, emergiu a consolidação do relacionamento entre saúde e escola, demonstrando a presença do diálogo intersetorial e incorporação das ações de saúde no cotidiano escolar. Escola desenvolvidas exploratóriodescritivo, exploratóriodescritivo exploratório descritivo, descritivo exploratório-descritivo qualitativa 2 programa Janeiro semiestruturadas tema Bardin higienistas referemse referem se humanos continuada organizacional território lado escola escolar

Abstract The study aimed to analyze the implementation of the School Health Program, identifying the actions developed, as well as factors that influence professional practice in daily life and strategies adopted by health professionals in view of the limitations found. The exploratory-descriptive case study method was used, with a qualitative approach. The study was carried out with 20 health professionals, program directors, in a family clinic in the city of Rio de Janeiro. Data were collected through semi-structured interviews, containing specific questions and open questions that discussed the topic. Data were analyzed using the Bardin technique. The results were grouped into categories and found the predominance of actions focused on biological and hygienist determinants, confirming the distance from the expanded concept of health in health promotion practices. The problems encountered refer to the scarcity of material and human resources, lack of training and continuing education, lack of planning and organizational infrastructure, violence in the territory, in addition to the pandemic period experienced during the study. On the other hand, the consolidation of the relationship between health and school emerged, demonstrating the presence of intersectoral dialogue and the incorporation of health actions in the school routine. Program developed exploratorydescriptive exploratory descriptive used approach 2 directors Janeiro semistructured semi structured interviews topic technique determinants practices resources education infrastructure territory hand emerged routine

SUMMARY OBJECTIVE: The aim of this study was to evaluate the serum hCG level in the differential diagnosis between non-molar miscarriage and complete hydatidiform mole in<11 weeks gestation. METHODS: This was a retrospective collaborative cohort study. This study included women with gestational age<11 weeks, with ultrasound evidence of failed pregnancy and available serum hCG pre-uterine evacuation, divided into two groups: the non-molar miscarriage group and the complete hydatidiform mole group. Serum hCG levels were compared according to gestational age. Statistical analysis used a nonparametric test with a 5% significance level (p<0.05). RESULTS: In total, 416 patients were included, out of which 79 were included in the non-molar miscarriage group and 337 in the complete hydatidiform mole group. The calculated power of the sample was more than 80%. Data analysis showed that the 75th quartile of the median in the non-molar miscarriage group was always lower than the 25th quartile of the median in the complete hydatidiform mole group [9,721 mUI/mL/16,435 mUI/mL (6–7 weeks), 20,229 mUI/mL/64,911 mUI/mL (8–9 weeks), and 29,633 mUI/mL/126,278 mUI/mL (10–11 weeks), respectively; p<0.001]. CONCLUSION: Facing failed pregnancies, hCG>16,435 mUI/mL at 6–7 weeks, hCG>64,911 mUI/mL at 8–9 weeks, and hCG >126,278 mUI/mL at 10–11 weeks were most prevalent on complete hydatidiform mole diagnosis. On the contrary, hCG<30,000 mUI/mL at 10–11 weeks was most prevalent in non-molar miscarriage diagnosis. OBJECTIVE nonmolar non molar in11 11 in<1 gestation METHODS age11 age age<1 preuterine pre uterine evacuation groups 5 p<0.05. p005 p p<0.05 . 0 05 (p<0.05) RESULTS total 41 7 33 80 80% th 9,721 9721 9 721 [9,72 mUImL16435 mUImL mUI mL 16 435 mUI/mL/16,43 67 6 (6– , weeks) 20229 20 229 20,22 mUImL64911 64 911 mUI/mL/64,91 89 8 (8– 29633 29 633 29,63 mUImL126278 126 278 mUI/mL/126,27 1011 10 (10–1 respectively p<0.001. p0001 p<0.001 001 p<0.001] CONCLUSION pregnancies hCG16435 hCG>16,43 6– hCG64911 hCG>64,91 8– 126278 >126,27 10–1 contrary hCG30000 30 000 hCG<30,00 in1 1 in< age1 age< p00 p<0.0 (p<0.05 4 3 9,72 972 72 [9,7 mUImL1643 43 mUI/mL/16,4 (6 2022 2 22 20,2 mUImL6491 91 mUI/mL/64,9 (8 2963 63 29,6 mUImL12627 12 27 mUI/mL/126,2 101 (10– p000 p<0.00 00 hCG1643 hCG>16,4 hCG6491 hCG>64,9 12627 >126,2 10– hCG3000 hCG<30,0 p0 p<0. (p<0.0 9,7 97 [9, mUImL164 mUI/mL/16, ( 202 20, mUImL649 mUI/mL/64, 296 29, mUImL1262 mUI/mL/126, (10 hCG164 hCG>16, hCG649 hCG>64, 1262 >126, hCG300 hCG<30, p<0 (p<0. 9, [9 mUImL16 mUI/mL/16 mUImL64 mUI/mL/64 mUImL126 mUI/mL/126 (1 hCG16 hCG>16 hCG64 hCG>64 >126 hCG30 hCG<30 p< (p<0 [ mUImL1 mUI/mL/1 mUImL6 mUI/mL/6 mUImL12 mUI/mL/12 hCG1 hCG>1 hCG6 hCG>6 >12 hCG3 hCG<3 (p< mUI/mL/ hCG> >1 hCG< (p >

Objetivo: analizar la correlación entre el tiempo en rango y la hemoglobina glicosilada de personas que viven con diabetes mellitus y realizan la monitorización continua de la glucemia o el automonitoreo de la glucemia capilar Método: revisión sistemática de etiología y riesgo basada en las directrices del JBI e informada según los Preferred Reporting Items for Systematic Reviews and Meta-Analyses, abarcando seis bases de datos y la literatura gris. La muestra incluyó 16 estudios y la calidad metodológica fue evaluada utilizando las herramientas del JBI. Protocolo registrado en Open Science Framework, disponible en https://doi.org/10.17605/OSF.IO/NKMZB. Resultados: tiempo en rango (70-180 mg/dl) mostró una correlación negativa con la hemoglobina glicosilada, mientras que el tiempo por encima del rango (>180 mg/dl) mostró una correlación positiva. Los coeficientes de correlación variaron entre -0,310 y -0,869 para el tiempo en rango, y entre 0,66 y 0,934 para el tiempo por encima del rango. Un estudio se realizó en una población que hacía el automonitoreo. Conclusión: hay una correlación estadísticamente significativa entre el tiempo en rango y el tiempo por encima del rango con la hemoglobina glicosilada. Cuanto mayor sea la proporción en el rango glucémico adecuado, más cerca o por debajo del 7% estará la hemoglobina glicosilada. Se necesitan más estudios que evalúen esta métrica con datos del automonitoreo de la glucemia. Objetivo Método MetaAnalyses, MetaAnalyses Meta Analyses, Analyses Meta-Analyses gris 1 Framework https//doi.org/10.17605/OSF.IO/NKMZB. httpsdoiorg1017605OSFIONKMZB httpsdoiorgOSFIONKMZB https //doi.org/10.17605/OSF.IO/NKMZB. doi org 10 17605 OSF IO NKMZB https://doi.org/10.17605/OSF.IO/NKMZB Resultados 70180 70 180 (70-18 mg/dl mgdl mg dl >180 (>18 positiva 0,310 0310 0 310 -0,31 0,869 0869 869 -0,86 066 66 0,6 0934 934 0,93 Conclusión adecuado 7 https//doi.org/10.17605/OSF.IO/NKMZB httpsdoiorg OSFIONKMZB doiorg1017605OSFIONKMZB doiorgOSFIONKMZB //doi.org/10.17605/OSF.IO/NKMZB 1760 7018 18 (70-1 >18 (>1 0,31 031 31 -0,3 0,86 086 86 -0,8 06 6 0, 093 93 0,9 doiorg 176 701 (70- >1 (> 0,3 03 3 -0, 0,8 08 8 09 9 17 (70 > ( -0 (7 -

Objective: to analyze the correlation between time on target and glycated hemoglobin in people living with diabetes mellitus and carrying out continuous blood glucose monitoring or self-monitoring of capillary blood glucose. Method: systematic review of etiology and risk based on JBI guidelines and reported according to Preferred Reporting Items for Systematic Reviews and Meta- Analyses, covering six databases and grey literature. The sample included 16 studies and methodological quality was assessed using JBI tools. Protocol registered in the Open Science Framework, available at https://doi.org/10.17605/OSF.IO/NKMZB. Results: time on target (70-180 mg/dl) showed a negative correlation with glycated hemoglobin, while time above target (>180 mg/dl) showed a positive correlation. Correlation coefficients ranged between -0.310 and -0.869 for time on target, and between 0.66 and 0.934 for time above target. A study was carried out on a population that performed self-monitoring. Conclusion: there is a statistically significant correlation between time on target and time above target with glycated hemoglobin. The higher the proportion in the adequate glycemic range, the closer to or less than 7% the glycated hemoglobin will be. More studies are needed to evaluate this metric with data from self-monitoring of blood glucose. Objective selfmonitoring self Method Meta Analyses literature 1 tools Framework https//doi.org/10.17605/OSF.IO/NKMZB. httpsdoiorg1017605OSFIONKMZB httpsdoiorgOSFIONKMZB https //doi.org/10.17605/OSF.IO/NKMZB. doi org 10 17605 OSF IO NKMZB https://doi.org/10.17605/OSF.IO/NKMZB Results 70180 70 180 (70-18 mg/dl mgdl mg dl >180 (>18 0.310 0310 0 310 -0.31 0.869 0869 869 -0.86 066 66 0.6 0934 934 0.93 selfmonitoring. monitoring. Conclusion range 7 be https//doi.org/10.17605/OSF.IO/NKMZB httpsdoiorg OSFIONKMZB doiorg1017605OSFIONKMZB doiorgOSFIONKMZB //doi.org/10.17605/OSF.IO/NKMZB 1760 7018 18 (70-1 >18 (>1 0.31 031 31 -0.3 0.86 086 86 -0.8 06 6 0. 093 93 0.9 doiorg 176 701 (70- >1 (> 0.3 03 3 -0. 0.8 08 8 09 9 17 (70 > ( -0 (7 -

Objetivo: analisar a correlação entre o tempo no alvo e a hemoglobina glicada de pessoas que vivem com diabetes mellitus e realizam a monitorização contínua da glicemia ou a automonitorização da glicemia capilar. Método: revisão sistemática de etiologia e de risco pautada nas diretrizes do JBI e reportada conforme Preferred Reporting Items for Systematic Reviews and Meta-Analyses, abrangendo seis bases de dados e a literatura cinzenta. A amostra incluiu 16 estudos e a qualidade metodológica foi avaliada utilizando as ferramentas do JBI. Registrado protocolo no Open Science Framework, disponível em https://doi.org/10.17605/OSF.IO/NKMZB. Resultados: tempo no alvo (70-180 mg/dl) apresentou correlação negativa com a hemoglobina glicada, enquanto o tempo acima do alvo (>180 mg/dl) mostrou correlação positiva. Os coeficientes de correlação variaram entre -0,310 e -0,869 para o tempo no alvo, e entre 0,66 e 0,934 para o tempo acima do alvo. Um estudo foi efetuado com população que realizava a automonitorização. Conclusão: há correlação estatisticamente significativa entre o tempo no alvo e o tempo acima do alvo com a hemoglobina glicada. Quanto maior a proporção na faixa glicêmica adequada, mais próxima ou inferior a 7% estará a hemoglobina glicada. São necessários mais estudos que avaliem essa métrica com dados da automonitorização da glicemia. Objetivo capilar Método MetaAnalyses, MetaAnalyses Meta Analyses, Analyses Meta-Analyses cinzenta 1 Framework https//doi.org/10.17605/OSF.IO/NKMZB. httpsdoiorg1017605OSFIONKMZB httpsdoiorgOSFIONKMZB https //doi.org/10.17605/OSF.IO/NKMZB. doi org 10 17605 OSF IO NKMZB https://doi.org/10.17605/OSF.IO/NKMZB Resultados 70180 70 180 (70-18 mg/dl mgdl mg dl >180 (>18 positiva 0,310 0310 0 310 -0,31 0,869 0869 869 -0,86 066 66 0,6 0934 934 0,93 Conclusão adequada 7 https//doi.org/10.17605/OSF.IO/NKMZB httpsdoiorg OSFIONKMZB doiorg1017605OSFIONKMZB doiorgOSFIONKMZB //doi.org/10.17605/OSF.IO/NKMZB 1760 7018 18 (70-1 >18 (>1 0,31 031 31 -0,3 0,86 086 86 -0,8 06 6 0, 093 93 0,9 doiorg 176 701 (70- >1 (> 0,3 03 3 -0, 0,8 08 8 09 9 17 (70 > ( -0 (7 -

RESUMO O Nordeste é a principal região produtora de frutos de maracujazeiro-amarelo no Brasil, que devido à escassez hídrica ocorrida nos últimos anos, os passifloricultores utilizam água de elevada concentração de sais para exploração da cultura. Dessa forma, o emprego de tecnologias que possibilite a atenuação do estresse salino às plantas é uma estratégia promissora nas condições de semiárido. Objetivou-se com o trabalho avaliar a ação de fertilizantes organominerais como atenuador do estresse salino sobre a fluorescência da clorofila a e trocas gasosas de mudas maracujazeiro-amarelo acesso ‘Guinezinho’. Os tratamentos foram distribuídos em blocos casualizados com quatro repetições e quatro mudas por parcela, empregando o esquema fatorial 2 × 3, referente às irrigação com água de baixa (0,18 dS m-1) e alta (4,00 dS m-1) condutividade elétrica e três atenuadores organomineral líquidos (Codasal®, Aminoagro Raiz® e mistura de Codasal® + Aminoagro Raiz® - proporção de 1/1 v/v), via fertirrigação. A irrigação com água de 4,0 dS m-1 associado com fertilizantes líquidos aumentam a salinidade do substrato e reduz a condutância estomática das mudas de maracujazeiro-amarelo, principalmente, com aplicação de Codasal®. A aplicação individual ou associado de Codasal® com Aminoagro Raiz® promove aumentos na fluorescência variável, eficiência quântica do PSII, taxa de assimilação de CO2 e eficiência instantânea de carboxilação em mudas de maracujazeiro-amarelo, acesso “Guinezinho”. maracujazeiroamarelo maracujazeiro amarelo Brasil anos cultura forma semiárido Objetivouse Objetivou se ‘Guinezinho. Guinezinho ‘Guinezinho . ‘Guinezinho’ parcela 3 0,18 018 0 18 (0,1 m1 m 1 4,00 400 4 00 (4,0 Codasal®, Codasal (Codasal® Raiz 11 1/ v/v, vv v/v , v v/v) fertirrigação 40 4, m- maracujazeiroamarelo, amarelo, principalmente variável PSII CO Guinezinho. “Guinezinho” 0,1 01 (0, (4, (Codasal “Guinezinho 0, (0 (4 (

ABSTRACT The Northeast region of Brazil is the primary producer of yellow passion fruit. In recent years, water scarcity has led passion fruit growers to use highly saline water for cultivation. Therefore, implementing technologies that alleviate the negative effects of salt stress on plants is a promising approach, particularly in semi-arid conditions. This study aimed to assess the efficacy of organomineral fertilizers in mitigating salt stress effects on chlorophyll-a fluorescence and gas exchange in ‘Guinezinho’ yellow passion fruit seedlings. The treatments were arranged in randomized blocks with four replicates and four seedlings per plot, following a 2 × 3 factorial design. The factors considered were irrigation using water with low (0.18 dS m-1) and high (4.0 dS m-1) electrical conductivity and three liquid organomineral attenuators (Codasal™, Aminoagro Raiz™, and a mixture of Codasal™ + Aminoagro Raiz™ at a 1:1 v/v ratio), applied through fertigation. Irrigation with water containing 4.0 dS m-1 electrical conductivity, combined with liquid fertilizers, resulted in increased substrate salinity, and reduced stomatal conductance in yellow passion fruit seedlings, particularly when Codasal™ was applied. Application of Codasal™ alone or in combination with Aminoagro Raiz™ significantly enhanced variable fluorescence, quantum efficiency of PSII, CO2 assimilation rate, and instantaneous carboxylation efficiency in ‘Guinezinho’ yellow passion fruit seedlings. years cultivation Therefore approach semiarid semi arid conditions chlorophylla chlorophyll ‘Guinezinho Guinezinho plot design 0.18 018 0 18 (0.1 m1 m 1 40 4 (4. Codasal™, Codasal (Codasal™ Raiz 11 1: vv v ratio, ratio , ratio) fertigation 4. m- salinity PSII CO rate 0.1 01 (0. (4 (Codasal 0. (0 (

Abstract The aim of this study was to investigate the impacts of COVID 19 on mental health among Health Sciences college students. This is a cross-sectional and quantitative study, the sample consisted of 618 university students of health sciences. Depressive symptoms were evaluated using the Patient Health Questionnaire 9 (PHQ-9). The prevalence of depressive symptoms was estimated and the relationship between severe depressive symptoms and associated factors was achieved through multivariate analysis of Poisson Regression. The prevalence of mild, moderate, or severe depressive symptoms was 87.2% among students, while the prevalence of severe depressive symptoms was 18.8%. The factors that were significantly associated with severe depressive symptoms were moderate to severe internet dependence (PR = 3.60), self-perceived health regular / poor (PR = 3.15), female gender (PR = 2, 11), sexual orientation (PR = 2.02), decreased family income during the COVID-19 Pandemic (PR = 1.87) and the presence of some chronic disease (PR = 1.77). The assessment of the prevalence of depressive symptoms among students of health sciences was high and, considering the potential underlying health commitment institutional policies should be outlined, aiming to promote and protect the mental health of this population, as well as mitigate the negative effects direct and indirect effects caused by COVID-19.

Resumo O objetivo deste estudo foi investigar os impactos da COVID-19 na saúde mental entre estudantes universitários de Ciências da Saúde. Trata-se de um estudo transversal e quantitativo, cuja amostra foi constituída por 618 estudantes universitários da área da saúde. Os sintomas depressivos foram avaliados por meio do Patient Health Questionnaire 9 (PHQ-9). A prevalência dos sintomas depressivos foi estimada e a relação entre sintomas depressivos severos e fatores associados foi obtida por meio de análise multivariada da Regressão de Poisson. A prevalência da sintomatologia depressiva, seja ela leve, moderada ou severa, foi de 87,2% entre os estudantes, enquanto a prevalência de sintomas depressivos severos foi de 18,8%. Os fatores que se associaram de forma significativa aos sintomas depressivos severos foram a dependência de internet moderada a grave (RP = 3,60), a autopercepção de saúde regular/ruim (RP = 3,15), o sexo feminino (RP = 2,11), orientação sexual (RP = 2,02), diminuição da renda familiar durante a Pandemia da COVID-19 (RP = 1,87) e presença de alguma doença crônica (RP = 1,77). A avaliação da prevalência de sintomas depressivos entre os estudantes de Ciências da Saúde foi elevada e, considerando o potencial comprometimento de saúde subjacente, políticas institucionais devem ser delineadas, visando promover e proteger a saúde mental dessa população, assim como mitigar os efeitos negativos diretos e indiretos causados pela COVID-19.

RESUMO Objetivo comparar a autoavaliação ao falar em público, por meio da Escala para Autoavaliação ao Falar em Público, com a percepção comunicacional e timidez autorreferidos, de estudantes universitários. Método tratou-se de um estudo observacional transversal prospectivo. Foram convidados a participar deste estudo, estudantes universitários do Brasil de diferentes áreas de conhecimento, sendo incluídos os que assentiram em participar. Os participantes receberam convite eletrônico e preencheram um formulário elaborado na plataforma Google Forms que continha questões sociodemográficas, sobre autopercepção como bom falante, sobre facilidade para se expressar, sobre timidez, e a Escala para Autoavaliação ao Falar em Público. Foram comparadas as médias da Escala de Autoavaliação ao Falar em Público com a autopercepção como bom falante, com a facilidade para se expressar e com a timidez. Resultados os participantes que se consideravam bons comunicadores, os que acreditavam ter facilidade para se expressar e os que não eram tímidos apresentaram melhor autopercepção sobre as suas habilidades de fala em público. Conclusão a autopercepção comunicacional positiva, bem como a autopercepção de menor timidez estão relacionadas a uma autoavaliação mais favorável em relação a apresentações em público.

ABSTRACT Purpose To compare self-assessment when speaking in public, using the Self-Statements During Public Speaking scale, with the communicational perception and self-reported shyness of university students. Methods This was a prospective cross-sectional observational study. University students from different areas of knowledge in Brazil were invited to participate in this study. Those who agreed to participate were included. Participants received an electronic invitation and filled out a form created on the Google Forms platform that contained sociodemographic questions, on self-perception as a good speaker, on ease of expression, on shyness, and the Self-Statements During Public Speaking scale. The means of the Self-Statements During Public Speaking scale were compared with the self-perception as a good speaker, the ease of expressing oneself, and shyness. Results Participants who considered themselves to be good communicators, those who believed they had an ease to express themselves, and those who were not shy had better self-perception of their public speaking skills. Conclusion positive communicational self-perception, as well as less shyness self-perception, are related to a more favorable self-assessment in relation to public presentations.

Abstract Objectives Evidence suggests that ketamine’s influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion There was no significant treatment impact on BDNF serum levels – neither with ketamine nor esketamine – despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion. This clinical trial is registered on the Japan Primary Registries Network: UMIN000032355. ketamines s brainderived brain derived (BDNF action treatmentresistant resistant . (TRD) 53 randomized doubleblind double blind singledose single dose 0.5mg/kg, 05mgkg mgkg 0 5mg kg mg (0.5mg/kg 27 0.25mg/kg, 025mgkg 25mg (0.25mg/kg 26 2 MontgomeryÅsberg Montgomery Åsberg MADRS. MADRS (MADRS) infusion afterwards postinfusion post points effect symptoms Network UMIN000032355 UMIN (TRD 5 0.5mg/kg 0.25mg/kg (MADRS UMIN00003235 UMIN0000323 UMIN000032 UMIN00003 UMIN0000 UMIN000 UMIN00 UMIN0

Abstract Background Cardiovascular Diseases (CVDs) are the main cause of mortality in Brazil, which includes acute myocardial infarction (AMI). In 2017, 12% of deaths caused by infarction in Brazil occurred in the state of Rio de Janeiro, characterizing it as an important “hotspot” in the country. Objectives This study aimed to characterize the population affected by AMI over the past decade within the state so as to guide future public policies related to CVDs. Methods Secondary data of patients affected by AMI between 2010 and 2019 were obtained by DATASUS. In-hospital case-fatality rates, mortality rates, and proportional mortality were calculated using information gathered by the Mortality Information System (SIM) and demographic statistics produced by the Brazilian Institute of Geography and Statistics (IBGE). Results The main results showed that in-hospital case-fatality rates were higher in women, patients aged 60 years and over, the black color/race, and the state's Northwest region. The mortality rate was higher among men, especially in the South-central region and those over 50 years of age. People aged 40-49 years presented a considerable risk of death by infarction. The major categories of data classified as “ignored” in hospital admissions and death certificates were those related to race and education level. Conclusions Prevention should not only focus on the elderly, but also on people over 40, especially men. The incompleteness of electronic public data systems can affect the use of race/color or education level as epidemiological variables. New studies should be conducted to understand why the South-central region is so heavily affected by infarction. CVDs (CVDs AMI. . (AMI) 2017 12 Janeiro hotspot “hotspot country 201 DATASUS Inhospital casefatality case fatality SIM (SIM IBGE. IBGE (IBGE) inhospital women 6 colorrace color color/race states s men Southcentral South central 5 age 4049 40 49 40-4 ignored “ignored elderly racecolor variables (AMI 1 20 (IBGE 404 4 40- 2

Resumo: Introdução: Os universitários de Ciências da Saúde se tornaram especialmente afetados pela pandemia do vírus Sars-CoV-2. As angústias intrinsicamente relacionadas à Covid-19 foram somadas aos impactos referentes às mudanças acontecidas nas instituições acadêmicas, particularmente a mudança para o ensino on-line, uma metodologia que pode gerar desconforto aos estudantes, além de vários obstáculos relacionados ao ensino e à aprendizagem, o que pode ter repercussões traumáticas importantes na saúde mental dessa população. Objetivo: Este estudo teve como objetivo verificar a carga mental provocada pela pandemia da Covid-19, como um evento traumático ao ponto de desencadear transtornos psiquiátricos, como o transtorno do estresse pós-traumático (Tept), em universitários. Método: Trata-se de um estudo transversal e quantitativo, com orientação analítico-descritiva, mediante preenchimento de formulário digital anônimo, iniciado após prévia aprovação do Comitê de Ética em Pesquisa. Os sujeitos foram estudantes de Ciências Biológicas e da Saúde de uma universidade estadual localizada na Região Sudeste do Brasil. A amostra foi constituída por 618 estudantes. Resultado: Foram respondidos 618 formulários pelos estudantes que pertenciam aos cursos de Educação Física (28,8%), Medicina (25,4%), Odontologia (18,1%), Ciências Biológicas (15,2%) e Enfermagem (12,5%). A presença de sintomas de estresse pós-traumático verificados pela Escala de Impacto do Evento-Revisada (IES-R) obteve prevalência de 32,7% (n = 202) entre os estudantes universitários das Ciências Biológicas e da Saúde. Conclusão: Houve impacto significativo na saúde mental dos universitários com presença de sintomas depressivos, ansiedade e estresse acima dos encontrados na literatura científica, e, consequentemente, constatou-se alta na prevalência do Tept. Resumo Introdução SarsCoV2. SarsCoV2 SarsCoV Sars CoV 2. 2 Sars-CoV-2 Covid19 Covid 19 Covid-1 acadêmicas online, online on line, line on-line aprendizagem população Objetivo Covid19, 19, psiquiátricos póstraumático pós Tept, Tept , (Tept) Método Tratase Trata quantitativo analíticodescritiva, analíticodescritiva analítico descritiva, descritiva analítico-descritiva anônimo Pesquisa Brasil 61 Resultado 28,8%, 288 28,8% 28 8 (28,8%) 25,4%, 254 25,4% 25 4 (25,4%) 18,1%, 181 18,1% 18 1 (18,1%) 15,2% 152 15 (15,2% 12,5%. 125 12,5% . 12 5 (12,5%) EventoRevisada Evento Revisada IESR IES R (IES-R 327 32 7 32,7 n 202 Conclusão depressivos científica consequentemente constatouse constatou Sars-CoV- Covid1 Covid- (Tept 6 28,8 (28,8% 25,4 (25,4% 18,1 (18,1% 15,2 (15,2 12,5 (12,5% 3 32, 20 Sars-CoV 28, (28,8 25, (25,4 18, (18,1 15, (15, 12, (12,5 (28, (25, (18, (15 (12, (28 (25 (18 (1 (12 (2 (

Abstract: Introduction: Health Sciences university students were especially affected by the Sars-CoV-2 virus pandemic. The anxieties intrinsically related to Covid-19 were added to the impacts related to the changes that have taken place in academic institutions, particularly the change to online teaching, a methodology that can generate discomfort for students, in addition to several obstacles related to teaching and learning, which can have important traumatic effects on the mental health of this population. Objective: To assess the mental health burden caused by the COVID-19 pandemic, as a traumatic event capable of triggering psychiatric disorders, such as Post-Traumatic Stress Disorder (PTSD), in university students. Methods: This is a cross-sectional and quantitative study, of analytical-descriptive nature, carried out by filling out an anonymous digital form, initiated after prior approval by the Research Ethics Committee. The subjects were students of Biological and Health Sciences at a State University located in the southeastern region of Brazil. The sample consisted of 618 students. Results: 618 forms were answered by students attending the courses of Physical Education (28.8%), Medicine (25.4%), Dentistry (18.1%), Biological Sciences (15.2%) and Nursing (12.5%). The presence of post-traumatic stress symptoms assessed by the Impact of Event Scale - Revised (IES-R) obtained a prevalence of 32.7% (n = 202) among university students from Biological and Health Sciences courses. Conclusions: There was a significant impact on the mental health of university students, with the presence of depressive symptoms, anxiety and stress above those found in the scientific literature and, consequently, a high prevalence of PTSD. Abstract Introduction SarsCoV2 SarsCoV Sars CoV 2 Sars-CoV- pandemic Covid19 Covid 19 Covid-1 institutions learning population Objective COVID19 COVID COVID-1 disorders PostTraumatic Post Traumatic PTSD, PTSD , (PTSD) Methods crosssectional cross sectional study analyticaldescriptive analytical descriptive nature form Committee Brazil 61 Results 28.8%, 288 28.8% 28 8 (28.8%) 25.4%, 254 25.4% 25 4 (25.4%) 18.1%, 181 18.1% 18 1 (18.1%) 15.2% 152 15 (15.2% 12.5%. 125 12.5% . 12 5 (12.5%) posttraumatic post IESR IES R (IES-R 327 32 7 32.7 n 202 Conclusions consequently Sars-CoV Covid1 Covid- COVID1 COVID- (PTSD 6 28.8 (28.8% 25.4 (25.4% 18.1 (18.1% 15.2 (15.2 12.5 (12.5% 3 32. 20 28. (28.8 25. (25.4 18. (18.1 15. (15. 12. (12.5 (28. (25. (18. (15 (12. (28 (25 (18 (1 (12 (2 (

Resumo Objetivo: Publicações de outrora utilizaram um dos principais fenômenos da cultura pop, Star Wars, para ensinar diversas questões sobre psiquiatria, demonstrando que usar os filmes da série para ensinar tais assuntos pode facilitar a compreensão de temas desafiadores. O objetivo deste artigo é aprofundar as questões do diagnóstico diferencial de dois transtornos psiquiátricos. Métodos: Nós examinamos e comparamos as especificidades do transtorno de personalidade borderline e transtorno bipolar à luz do personagem fictício dos filmes Star Wars, o vilão Darth Vader/Anakin Skywalker. Resultados e Conclusão: As considerações sobre o diagnóstico de Darth Vader devem ser interpretadas como um exercício acadêmico com dois objetivos principais: discutir o diagnóstico diferencial entre transtorno de personalidade borderline e transtorno bipolar de forma ilustrativa, suave e lúdica; e ensinar como relacionar os comportamentos com critérios diagnósticos, neste caso, especificamente relacionados ao transtorno de personalidade borderline. Objetivo pop Wars psiquiatria desafiadores psiquiátricos Métodos VaderAnakin Anakin Skywalker Conclusão ilustrativa lúdica diagnósticos caso

Abstract Objective: Previous publications have focused on a leading pop culture phenomenon, Star Wars, to teach several issues in psychiatry, which can make understanding challenging themes easier. This article delves into matters of differential diagnoses regarding two psychiatric disorders. Methods: We examine and compare the symptoms and specificities of borderline personality disorder and bipolar disorder in the light of the fictional villain of the films, Darth Vader/Anakin Skywalker. Results and Conclusion: Our considerations of his diagnosis should be interpreted as an academic exercise with two main goals: to discuss the differential diagnosis between borderline personality disorder and bipolar disorder in an illustrative, soft, and ludic way; and to teach how to connect one’s behaviors with diagnostic criteria - in this case, those related to borderline personality disorder. Objective phenomenon Wars psychiatry easier disorders Methods films VaderAnakin Vader Anakin Skywalker Conclusion goals illustrative soft way ones one s case

Resumen Este proyecto tuve como objetivo analizar la relación entre el arte y la vida, según Vigotski. Para esto, fue realizado un análisis de los capítulos 1, 7, 9, 10 y 11 de Psicología del arte, del capítulo 13 de Psicología Pedagógica y del texto Él significado histórico de la crisis de la Psicología: una investigación metodológica. La pesquisa conceptual consiste en la analice semántica de los conceptos de una teoría, para aclarar sus significados ocultos o confusos y desvendar contradicciones y ambigüedades em el cuadro teórico. Pudimos observar que, el arte es un fenómeno dialéctico en su creación tanto como en sus efectos. La influencia de la vida, esto es, de la realidad socio-histórica, en la creación artística es indirecta, pues es mediada por el psiquismo particular de lo artista. Así, el efecto del arte sobre la vida habilita que lo ser humano adquiera conciencia de su realidad social y que se comprometa a cambiarla. El arte, consiguientemente, transformadora, pues reorganiza lo psiquismo y habilita un cambio en las condiciones materiales de los seres humanos. Vigotski 1 7 9 metodológica teoría teórico efectos sociohistórica, sociohistórica socio histórica, histórica socio-histórica indirecta artista Así cambiarla consiguientemente transformadora humanos

Resumo Este trabalho teve como objetivo analisar a relação entre arte e vida segundo Vigotski. Para isso, foi realizada uma análise conceitual dos capítulos 1, 7, 9, 10 e 11 da Psicologia da Arte, do capítulo 13 da Psicologia Pedagógica e do texto O significado histórico da crise da Psicologia: Uma investigação metodológica. A pesquisa conceitual consiste na análise semântica dos principais conceitos de uma teoria com o intuito de elucidar seus sentidos ocultos ou confusos e desvendar possíveis contradições e ambiguidades no quadro teórico. Podemos observar que a arte é um fenômeno dialético tanto em sua criação como em seus efeitos. A influência da vida, isto é, da realidade sócio-histórica, na criação artística é indireta, pois ela é sempre mediada pelo psiquismo particular do artista. Já o efeito da arte sobre a vida possibilita que o ser humano se conscientize de sua realidade social e se engaje para mudá-la. A arte é, portanto, transformadora, pois reorganiza o psiquismo e possibilita uma mudança nas condições materiais dos seres humanos. Vigotski isso 1 7 9 Arte metodológica teórico efeitos sóciohistórica, sóciohistórica sócio histórica, histórica sócio-histórica indireta artista mudála. mudála mudá la. la mudá-la portanto transformadora humanos

Abstract This study aims to analyze the relationship between art and life according to Vygotsky. Therefore, a conceptual analysis of chapters 1, 7, 9, 10, and 11 of Psychology of Art, chapter 13 of Educational Psychology and the text The Historical meaning of the Crisis of Psychology: A Methodological Investigation was carried out. Conceptual research consists of the semantic analysis of the main concepts of a theory to elucidate its hidden or confused meanings and to reveal possible contradictions and ambiguities in the theoretical framework. Results show that art is a dialectical phenomenon both in its creation and its effects. The influence of life, that is, of socio-historical reality, on artistic creation is indirect since it is always mediated by the artist’s particular psyche. The effect of art on life, on the other hand, allows human beings to become aware of their social reality and engage to change it. Art is, therefore, transformative, as it reorganizes the psyche and enables a change in the material conditions of human beings. Vygotsky Therefore 1 7 9 10 out framework effects sociohistorical socio historical artists artist s hand therefore transformative

RESUMEN Objetivo: El presente estudio tiene como objetivo establecer un corte clínico para la dimensión Grandiosidad, utilizando procedimientos de evaluación a nivel de ítem. Métodos: Los participantes fueron 5.387 adultos, entre pacientes ambulatorios diagnosticados con trastorno de personalidad narcisista (NPD), pacientes ambulatorios diagnosticados con otros trastornos de la personalidad, y adultos de la comunidad. Se administró la escala de Grandiosidad autoinformada del Inventario Dimensional Clínico de Personalidad 2 (IDCP-2). El procedimiento de ecualización se aplicó para generar puntuaciones theta para los participantes que no respondieron a todos los ítems. Resultados: El mapa de Wright reveló que los pacientes ambulatorios estaban ubicados en los niveles altos en el continuo latente de la escala de Grandiosidad. La comparación grupal mostró tamaños de efecto grandes para la diferencia de medias entre pacientes y no pacientes. La curva ROC confirma un corte en -.45 puntos en la estandarización theta que produce una alta sensibilidad (91%) y una especificidad moderada (58%). Además, los valores de PPP (71%) y NPP (79%) indican que la escala puede identificar a los pacientes con NPD en el 71% de los casos y las personas sin NPD en el 79% de los casos. Conclusiones: Los resultados indican que la escala de Grandiosidad del IDCP-2 es útil como instrumento de evaluación para NPD. Se describen posibles aplicaciones clínicas para la escala y se discuten las limitaciones del estudio.

ABSTRACT Objective: The present study aims to establish a clinical cut-off for the Grandiosity dimension, using item-level evaluation procedures. Methods: Participants were 5,387 adults, including outpatients diagnosed with narcissistic personality disorder (NPD), outpatients diagnosed with other personality disorders, and adults from the community. We administered the self-reported Grandiosity scale from the Dimensional Clinical Personality Inventory 2 (IDCP-2). The equating procedure was applied to generate theta scores for participants who did not answer all items. Results: The Wright map revealed that outpatients scored high on the latent continuum of the Grandiosity scale. Group comparison showed large effect sizes for the mean difference between patients and non-patients. The ROC curve supports a cut off at a -0.45 score in theta standardisation, which yields a high sensitivity (91%) and moderate specificity (58%). Moreover, the PPP (71%) and NPP (79%) values suggest that the scale is able to identify NPD patients in 71% of cases, and people without NPD in 79% of cases. Conclusions: The findings suggest the IDCP-2 Grandiosity scale is useful as an NPD screening tool. Possible clinical applications for the scale are described and the limitations of the study are discussed.

Resumen Este estudio tuvo como objetivo investigar la capacidad discriminativa de los factores IDCP-2 para identificar a las per-sonas con riesgo de suicidio. Además, estamos proporcionando un indicador de suicidio para IDCP-2. Participaron 346 personas de entre 18 y 72 anos que respondieron a ASIQ, IDCP-2 y PID-5. Dividimos a los participantes en tres grupos: grupo de bajo riesgo, grupo de riesgo moderado y grupo de alto riesgo. Realizamos comparaciones de medias, análisis de regresión lineal y verificación de curva ROC. Los factores IDCP-2 pudieron discriminar entre los grupos, y el alto riesgo presentò los medios más altos. La regresión indicò autodevaluación y desesperanza como variables con una contribución única significativa en la explicaciòn del comportamiento suicida. Los indicadores de riesgo de suicidio demostraron un rendimiento adecuado en la identificaciòn de personas según el grupo de riesgo. Nuestros hallazgos indican que los factores IDCP-2 pueden discriminar grupos de personas de acuerdo con el comportamiento suicida. Además, el indicador de suicidio desarrollado mostrò sensibilidad en la identificaciòn de personas que informaron intento de suicidio.

Abstract This study aimed to investigate the discriminative capacity of IDCP-2 factors to identify people with suicide risk. Moreover, we are providing a suicide indicator for IDCP-2. Participated 346 people aged between 18 and 72 years who responded to ASIQ, IDCP-2, and PID-5. We divided participants into three groups: low-risk group, moderate-risk, and high-risk group. We conducted mean comparisons, linear regression analysis, and ROC curve verification. The IDCP-2 factors were able to discriminate between the groups, with the high-risk presenting the highest means. The regression indicated Self-devaluation and Hopelessness as variables with a significant single contribution in explaining suicidal behavior. Suicide risk indicators demonstrated adequate performance in identifying people according to the risk group. Our findings indicate that the IDCP-2 factors can discriminate groups of people according to suicidal behavior. Besides, the suicide indicator developed showed sensitivity in the identification of people who reported attempted suicide.