ABSTRACT Objective Weight regain is a common outcome of weight loss interventions. Mental health-related comorbidities, among other factors, can mediate weight regain regardless of the implemented treatment modality. This study explores whether postoperative psychopathological comorbidities are associated with weight regain after bariatric surgery. Subjects and methods This cross-sectional study recruited 90 outpatients who underwent Roux-en-Y gastric bypass surgery. Anthropometric measurements were collected retrospectively from medical charts. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorder-IV (DSM-IV) Axis I Disorders (SCID-I) was applied to evaluate psychiatry diagnoses. Validated self-report instruments were used to assess depression, anxiety, alcohol use, impulsivity, binge eating, and body image dissatisfaction. Weight regain was defined as a ≥20% increase from the maximum weight lost. Level of evidence: Level III, cross-sectional study based on a well-designed study. Results Overall, 55.6% of participants experienced weight regain. Notably, mental disorders such as current binge-eating disorder and lifetime diagnoses including bulimia nervosa, alcohol abuse/dependence, and obsessive-compulsive disorder were significantly associated with weight regain. However, controlled analysis found that, for mental disorders, only current binge-eating disorder (odds ratio [OR] 6.3, 95% confidence interval [CI] 1.26-31.06, p = 0.024) remained associated with weight regain. Eating-related psychopathologies also associated with weight regain included binge eating (d = 0.55; p = 0.013), eating disinhibition (d = 0.76; p = 0.001), higher hunger levels (d = 0.39; p = 0.004), and non-planning trait impulsivity (d = 0.69; p = 0.0001). Conclusion Postoperative presence of psychopathological comorbidities, such as eating psychopathology and trait impulsivity, were associated with weight regain after bariatric surgery. These findings highlight the importance of addressing mental health in individuals experiencing postsurgical weight regain. interventions healthrelated related factors modality surgery crosssectional cross sectional 9 RouxenY Roux en Y charts DisorderIV Disorder IV DSMIV DSM (DSM-IV SCIDI SCID (SCID-I selfreport self report depression anxiety use dissatisfaction 20 ≥20 lost evidence III welldesigned well designed Overall 556 55 6 55.6 Notably bingeeating nervosa abusedependence abuse dependence abuse/dependence obsessivecompulsive obsessive compulsive However that odds OR [OR 63 3 6.3 95 CI [CI 1.2631.06, 1263106 1.26 31.06, 1 26 31 06 1.26-31.06 0.024 0024 0 024 Eatingrelated Eating d 0.55 055 0.013, 0013 0.013 , 013 0.013) 0.76 076 76 0.001, 0001 0.001 001 0.001) 0.39 039 39 0.004, 0004 0.004 004 0.004) nonplanning non planning 0.69 069 69 0.0001. 00001 0.0001 . 0.0001) 2 ≥2 5 55. 6. 2631 1.2631.06 126310 126 1.2 3106 31.06 1.26-31.0 0.02 002 02 0.5 05 0.01 01 0.7 07 7 000 0.00 00 0.3 03 0.6 0000 0.000 ≥ 263 1.2631.0 12631 12 1. 310 31.0 1.26-31. 0.0 0. 1.2631. 1263 31. 1.26-31 1.2631 1.26-3 1.263 1.26-

Abstract Background: Obesity has repercussions on functional capacity (FC). The six-minute walk test (6MWT) is a useful tool for assessing submaximal FC, and the distance reached at 6 minutes of walking (D6MW) is a relevant prognostic marker. Objective: This paper aims to establish a reference equation for the distance predicted in 6MWT in obese Brazilian subjects. Methods: This study included 460 patients (306 women), with a body mass index (BMI) > 30 kg/m2, 71% (328) of whom presented a grade III obesity (BMI ≥ 40 Kg/m²) and were evaluated with 6MWT. Heart rate, blood pressure, oxygen saturation and Borg scale perception of effort were recorded before and after the 6MWT. For statistical analysis, Kolmogorov-Smirnov tests, an unpaired T-Test, Pearson's correlation, and multiple linear regression were used, together with a significance level set at p<0.05. Results: Gender, age, and BMI were significantly correlated with D6MW and were identified by multiple linear regression as the best predictors of the D6MW. Together, they explain 48.7% of the D6MW variance for obese Brazilian subjects. Based on these findings, an equation was proposed – D6MW = 930.138 + (27.130 x Genderfemales = 0; males = 1) − (5.550 x BMI kg/m2) − (4.442 x Age years). When the average of the D6MW obtained with the above equation was compared to the average calculated with the equations described in medical literature for healthy and obese individuals, the latter tended to overestimate the D6MW. Conclusion: The proposed reference equation exhibited better assessment of FC in obese Brazilian patients, providing proper subsidies for the follow up ofinterventions in this population..

Abstract Obesity is a major public health problem worldwide. It has a complex etiology, influenced by environmental and genetic factors. FTO has been recognized as an important genetic factor for obesity development. This study evaluated the contribution of FTO polymorphisms (rs9939609 and rs17817449) for extreme obesity in terms of the period of obesity onset, anthropometric, and biochemical parameters. The haplotype and the combined effects of FTO risk alleles on obesity susceptibility were evaluated. We investigated 169 normal-weight subjects (body mass index, BMI: 22.8 [21.0; 24.0] kg/m2) and 123 extremely obese individuals (BMI: 47.6 [44.1; 53.1] kg/m2). Genotyping was performed by real time PCR. Our results showed a strong association between FTO variants and extreme obesity. Carriers of the AT haplotype had an increased risk for extreme obesity. Gene scores suggested that the risk of developing extreme obesity was increased 1.37-fold per risk allele added. Both polymorphisms also influenced BMI and body weight. Additionally, rs17817449 influenced triglyceride levels. No effect of FTO variants on the period of obesity onset was found. In conclusion, the FTO polymorphisms showed a strong association with development of extreme phenotype of obesity and adiposity modulation in a Brazilian population.

RESUMO A cirurgia bariátrica (CB) é considerada o tratamento mais eficaz para obesidade grave em longo prazo. Apesar de estar associada à resolução ou melhora das comorbidades clínicas, um desfecho possível é o reganho de peso. Um conjunto de evidências aponta a presença do transtorno da compulsão alimentar (TCA) como um dos fatores de risco associados ao reganho de peso pós-operatório. O objetivo desta apresentação de casos clínicos é discutir o possível impacto dos episódios de compulsão alimentar em pacientes submetidos à CB. Serão apresentados os seguintes casos (1): uma mulher de 41 anos, avaliada após 8 anos da cirurgia, apresentando um reganho de 22,9 kg e psicopatologia alimentar compatível com TCA; (2): um homem de 48 anos, avaliado no pós-operatório de 7 anos, com um reganho de 30 kg e exibindo queixas de beliscamento alimentar, porém sem sintomas compatíveis com TCA; (3): uma mulher de 44 anos, avaliada no pós-operatório de 3 anos, mantendo peso estável sem reganho e que exibia à avaliação TCA. Os autores discutem, a partir destes três casos, as evidências relacionadas ao impacto da compulsão alimentar no resultado da CB. Apesar de não haver, no momento, um consenso definitivo quanto ao real impacto dos transtornos alimentares neste recrudescimento ponderal, fica claro que o clínico deve estar atento ao TCA e sua possível associação com o reganho de peso.

ABSTRACT Bariatric surgery (BS) is the most effectiveness long term treatment to severe obesity. However being associated with resolution or improvement of clinic comorbidities, one possible outcome is weight regain. A group of evidences appoint to the presence of BED (binge eating disorder) as one risk factor associated to post-surgery weight regain. The aim of this case report is to discuss a possible impact of binge eating in patients submitted to BS. The following cases will be presented: (1): 41 years woman, evaluated after 8 years post-surgery, showing weight regain of 22.9 kg and compatible eating psychopathology with BED; (2): 48 years men, evaluated 7 years post-surgery, with weight regain of 30 kg and showing grazing complaints, although without compatible BED symptomatology; (3): 44 years woman, evaluated 3 years post-surgery, maintaining stable weight without weight regain and BED exhibited in evaluation. The authors discuss, from these three index cases, the associated evidences related to the impact of the binge eating in the BS result. Although, for the moment, any definitely consensus on the real impact of eating disorders in weight recrudescence is not possible, it is clear that the clinician need to be alert to BED and possible association with weight regain.

Resumen Introducción: la obesidad mórbida es una enfermedad de etiología multifactorial, de gran prevalencia en el mundo, que guarda relación directa con otras comorbilidades. Objetivo: analizar las respuestas cardiovasculares de pacientes mujeres con obesidad mórbida, a través de un test de esfuerzo máximo para la estratificación del riesgo y la prescripción de ejercicio. Método: se incluyeron trece pacientes con obesidad grado III, de sexo femenino, con edad entre 20 a 40 años, que fueron sometidas a un test ergoespirométrico en el cicloergómetro de miembros superiores para la verificación y el análisis de la frecuencia cardiaca, la presión arterial y el doble producto. Resultados: las pacientes con media de edad de 34,7 ± 5,1 años tenían índice de masa corporal de 46,5 ± 3,8 kg/m2. Alcanzaron una frecuencia cardíaca máxima de 168,2 ± 14,6 lpm, sin respuesta hipertensiva al esfuerzo, y presión arterial de 171,1 ± 22,2 mm Hg (sistólica) x 87,5 ± 4,2 mm Hg (diastólica). El doble producto máximo encontrado fue de 28.662,2 ±3.644,1 mm Hg.lpm. Conclusión: de acuerdo con los resultados de este estudio se observó una reducción de la frecuencia cardiaca, la presión arterial y el doble producto cardiaco, compatible con el esfuerzo esperado para el test.

Abstract Introduction: Morbid obesity is a condition of multifactorial origin with a high prevalence worldwide, and has a direct relationship with other illnesses. Objective: To analyse the cardiovascular responses of morbid obese women using a máximum stress test for stratifying risk and the prescribing of exercise. Method: The study included 13 patients with Grade III obesity. All were women between 20 and 40 years of age. Their arms were subjected to an ergospirometry test on the cycle ergometry in order to check and analyse heart rate, blood pressure, and the double product. Results: The patients had a mean age of 34.7 ± 5.1 years, and a mean body mass index of46.5 ± 3.8 kg/m2. A maximum heart rate of 168.2 ± 14.6 bpm was achieved, with no hypertensive response to the stress, and blood pressure of 171.1 ± 22.2 mm Hg (systolic) x 87.5 ± 4.2 mm Hg (diastolic). The maximum double product found was 28,662.2 ±3,644.1 mm Hg.bpm. Conclusion: In the results of this study is observed reduction of heart rate, blood pressure, and the double cardiac product, compatible with the expected effort for the test.

Resumo Fundamentos: A obesidade mórbida está diretamente relacionada à deterioração da capacidade cardiorrespiratória, incluindo alterações na modulação autonômica cardiovascular. Objetivo: Este estudo teve por objetivo avaliar a função autonômica cardiovascular de obesos mórbidos. Métodos: Estudo transversal, incluindo dois grupos, Grupo I, composto por 50 obesos mórbidos, e Grupo II, por 30 indivíduos não obesos. A função autonômica foi avaliada pela variabilidade da frequência cardíaca no domínio do tempo [desvio padrão de todos os intervalos R-R normais (SDNN); desvio-padrão de todos os intervalos R-R normais (SDNN); raiz quadrada das médias quadráticas das diferenças dos intervalos R-R sucessivos (RMSSD); e o percentual de diferenças de intervalo intervalos R-R sucessivos maior que 50 milissegundos (pNN50)] em comparação ao adjacente, e no domínio da frequência (HF, do inglês, “high frequency”, e LF, do inglês, “low frequency”: integração da função da densidade espectral de potência para as bandas de alta e baixa frequência, respectivamente). Os grupos foram comparados pelo teste t de Student, considerando-se um nível de significância de 5%. Resultados: Quando comparados aos controles, os indivíduos obesos apresentaram valores menores de SDNN (40,0 ± 18,0 ms vs. 70,0 ± 27,8 ms; p = 0,0004), RMSSD (23,7 ± 13,0 ms vs. 40,3 ± 22,4 ms; p = 0,0030), pNN50 (14,8 ± 10,4 % vs. 25,9 ± 7,2%; p = 0,0061) e HF (30,0 ± 17,5 Hz vs. 51,7 ± 25,5 Hz; p = 0,0023). A relação LF/HF média foi maior no Grupo I (5,0 ± 2,8 vs. 1,0 ± 0,9; p = 0,0189), refletindo alteração no equilíbrio simpato-vagal. Não houve diferença estatística entre os grupos I e II com relação ao índice LF (50,1 ± 30,2 Hz vs. 40,9 ± 23,9 Hz; p = 0,9013). Conclusão: obesos mórbidos apresentam aumento de atividade simpática e redução da atividade parassimpática, caracterizando uma disfunção autonômica cardiovascular.

Abstract Background: Morbid obesity is directly related to deterioration in cardiorespiratory capacity, including changes in cardiovascular autonomic modulation. Objective: This study aimed to assess the cardiovascular autonomic function in morbidly obese individuals. Methods: Cross-sectional study, including two groups of participants: Group I, composed by 50 morbidly obese subjects, and Group II, composed by 30 nonobese subjects. The autonomic function was assessed by heart rate variability in the time domain (standard deviation of all normal RR intervals [SDNN]; standard deviation of the normal R-R intervals [SDNN]; square root of the mean squared differences of successive R-R intervals [RMSSD]; and the percentage of interval differences of successive R-R intervals greater than 50 milliseconds [pNN50] than the adjacent interval), and in the frequency domain (high frequency [HF]; low frequency [LF]: integration of power spectral density function in high frequency and low frequency ranges respectively). Between-group comparisons were performed by the Student’s t-test, with a level of significance of 5%. Results: Obese subjects had lower values of SDNN (40.0 ± 18.0 ms vs. 70.0 ± 27.8 ms; p = 0.0004), RMSSD (23.7 ± 13.0 ms vs. 40.3 ± 22.4 ms; p = 0.0030), pNN50 (14.8 ± 10.4 % vs. 25.9 ± 7.2%; p = 0.0061) and HF (30.0 ± 17.5 Hz vs. 51.7 ± 25.5 Hz; p = 0.0023) than controls. Mean LF/HF ratio was higher in Group I (5.0 ± 2.8 vs. 1.0 ± 0.9; p = 0.0189), indicating changes in the sympathovagal balance. No statistical difference in LF was observed between Group I and Group II (50.1 ± 30.2 Hz vs. 40.9 ± 23.9 Hz; p = 0.9013). Conclusion: morbidly obese individuals have increased sympathetic activity and reduced parasympathetic activity, featuring cardiovascular autonomic dysfunction.

OBJETIVOS: Avaliar a prevalência de bócio e doença nodular tireoidiana em pacientes com obesidade grau III e correlacionar os resultados com os níveis de leptina e parâmetros de resistência à ação da insulina (RI). SUJEITOS E MÉTODOS: Estudo seccional foi desenvolvido realizando ultrassonografia (US) tireoidiana e níveis séricos de HOMA-IR e TSH nos pacientes obesos e nos controles. RESULTADOS: Volume tireoidiano foi positivamente correlacionado com índice de massa corporal (IMC) (r = 0,240, p = 0,039) e com HOMA (r = 0,329; p < 0,01). Volume tireoidiano e prevalência de doença nodular tireoidiana foram similares entre os grupos. Quando avaliado o subgrupo masculino, maiores volumes tireoidianos foram detectados no grupo dos obesos comparados aos controles (10,8 vs. 8,5 cm³; p = 0,04), nódulos foram mais frequentes (67% vs. 18%), assim como nódulos com indicação de punção (33,3% vs. 0%, p ≥ 0,05-0,09). CONCLUSÃO: Embora RI não se correlacione diretamente com a presença de nódulos, os resultados suportam a hipótese da direta associação entre resistência à ação da insulina e volume tireoidiano.

OBJECTIVES: To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, and to correlate results with serum leptin levels and insulin resistance (IR) parameters. SUBJECTS AND METHODS: A cross-sectional study was performed to assess thyroid ultrasound (US) patterns, HOMA-IR, serum leptin, and TSH levels in obese patients and controls. RESULTS: Thyroid volume was positively correlated with body mass index (BMI) (r = 0.240, p = 0.039) and with HOMA-IR (r = 0.329; p < 0.01). Thyroid US patterns were similar between groups. However, when data from the male group was considered, greater thyroid volume was detected in the obese group compared with controls (10.8 vs. 8.5 cm³; p = 0.04). Also, nodules were more frequently detected (67% vs. 18%), as were nodules requiring FNAB (33.3% vs. 0%, p ≥ 0.05-0.09), in this group. CONCLUSION: Although IR did not correlate directly with the presence of nodules, the results support the hypothesis of a direct association between insulin resistance and thyroid volume.

A obesidade mórbida é uma condição clínica que afeta a capacidade funcional, sendo a musculatura respiratória igualmente comprometida. Objetivou-se avaliar a força muscular inspiratória e expiratória de mulheres obesas mórbidas (MO) e eutróficas (ME). Estudo transversal com amostra composta por 21 mulheres (14 MO e 7 ME), pareadas pela idade e altura. A avaliação da força muscular inspiratória e expiratória foi realizada por meio da verificação das pressões inspiratória e expiratória por manovacuometria. Quando comparadas as pressões respiratórias estáticas máximas obtidas com os valores preditos para ME e MO, constata-se que as do primeiro grupo apresentam valores de P Imáx=119,14±1,9 cmH2O (152% do predito) e P Emáx=141,1±10,2 cmH2O (98,5% do predito) dentro dos limites de normalidade ou acima, enquanto no grupo de obesas mórbidas os valores de P Imáx=66±18,7 cmH2O (84,3% do predito) e P Emáx=78,4±14,2 cmH2O (54,3% do predito) foram inferiores aos preditos. Comparando-se as pressões respiratórias estáticas máximas obtidas de MO com ME, observa-se diferença significativa tanto para os valores de P Imáx (66±18,7 versus 119±1,9 cmH2O) como P Emáx (78,4±14,2 versus 141,14±10,20) com significância estatística de 0,001. Conclui-se que a força muscular respiratória é marcadamente diminuída em MO, quando comparadas a ME.

The morbid obesity is a clinical condition that affects functional capacity, and the respiratory muscles are also impaired. This study aimed to evaluate the inspiratory and expiratory muscle strength of morbidly obese women (OW) and eutrophic women (EW). Cross-sectional study, whose sample was composed by 21 women (14 OW and 7 EW) paired by age and height. Inspiratory and expiratory muscle strength evaluation was carried out by means of maximal inspiratory and expiratory pressure recordings (MIP and MEP, respectively) using manovacuometry. When comparing the maximal static respiratory pressures with predicted values for OW and EW, we observed that EW presented values of MIP=119.14±1.9 cmH2O (152% of predicted value) and MEP=141.1±10.2 cmH2O (98.5% of predicted value) within or above normal limits, while in OW group, MIP=66±18.7 cmH2O (84.3% of predicted value) and MEP=78.4±14.2 cmH2O (54.3% of predicted value) were lower than the predicted values. When comparing maximal static respiratory pressures of OW and EW, we observed a significant difference for MIP (66±18.7 versus 119±1.9 cmH2O) and MEP=78.4±14.2 versus 141.14±10.20) with statistical significance of 0.001. We conclude that respiratory muscle strength is notably decreased in OW when compared to EW.