Abstract Objectives: To review and provide evidence-based recommendations for the diagnosis and treatment of otosclerosis. Methods: Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on otosclerosis were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions. Results: The topics were divided into 2 parts: 1) Diagnosis – audiologic and radiologic; 2) Treatment – hearing AIDS, pharmacological therapy, stapes surgery, and implantable devices - bone-anchored devices, active middle ear implants, and Cochlear Implants (CI). Conclusions: The pathophysiology of otosclerosis has not yet been fully elucidated, but environmental factors and unidentified genes are likely to play a significant role in it. Women with otosclerosis are not at increased risk of worsening clinical condition due to the use of contraceptives or during pregnancy. Drug treatment has shown little benefit. If the patient does not want to undergo stapedotomy, the use of hearing aids is well indicated. Implantable systems should be indicated only in rare cases, and the CI should be indicated in cases of profound deafness. Objectives evidencebased based Methods methods search citations studies inclusion Physicians Associations Association s interventions Results parts 1 radiologic AIDS therapy surgery boneanchored bone anchored implants CI. . (CI) Conclusions elucidated it pregnancy benefit stapedotomy deafness (CI

RESUMO Objetivo: Apresentar um modelo de pesquisa e treinamento em transplante multivisceral em suínos. Métodos: Oito porcos da raça Large White (quatro doadores e quatro receptores) foram operados. O transplante multivisceral com estômago, duodeno, pâncreas, fígado e intestino foi realizado a semelhança do transplante em seres humanos com algumas diferenças descritas a seguir. Foram realizadas as anastomoses de veia cava supra-hepática do enxerto com a veia cava do receptor justa diafragmática término-terminal, veia cava infrahepática do enxerto com a veia cava inferior (suprarrenal) do receptor término-terminal e patch da aorta do enxerto com a aorta infrarrenal do receptor término-lateral e reconstrução digestiva. Resultados: Foi possível a realização do transplante multivisceral nos quatro animais. A reperfusão do enxerto multivisceral levou a uma grave síndrome de isquemia-reperfusão, apesar do flush do enxerto. Os animais apresentaram hipotensão com necessidade de drogas vasoativas em altas doses, sendo todos sacrificados com a retirada dessas drogas. Conclusão: Alternativas para minimizar a síndrome de isquemiareperfusão, como o uso de mais de uma droga vasoativa, uso de um terceiro porco apenas para transfusão sanguínea, presença de uma equipe de anestesia na sala de cirurgia e redução do enxerto, serão os próximos passos para possibilitar estudos experimentais.

ABSTRACT Objective: To present a model for research and training in multivisceral transplantation in pigs. Methods: Eight Large White pigs (four donors and four recipients) were operated. The multivisceral transplant with stomach, duodenum, pancreas, liver and intestine was performed similarly to transplantation in humans with a few differences, described below. Anastomoses were performed as follows: end-to-end from the supra-hepatic vena cava of the graft to the recipient juxta diaphragmatic vena cava; end-to-end from the infra-hepatic vena cava of the graft to the inferior (suprarenal) vena cava of the recipient; and end-to-side patch of the aorta of the graft to the infrarenal aorta of the recipient plus digestive reconstruction. Results: The performance of the multivisceral transplantion was possible in all four animals. Reperfusions of the multivisceral graft led to a severe ischemia-reperfusion syndrome, despite flushing of the graft. The animals presented with hypotension and the need for high doses of vasoactive drugs, and all of them were sacrificed after discontinuing these drugs. Conclusion: Some alternatives to minimize the ischemia-reperfusion syndrome, such as the use of another vasoactive drug, use of a third pig merely for blood transfusion, presence of an anesthesia team in the operating room, and reduction of the graft, will be the next steps to enable experimental studies.

OBJETIVO: Avaliar as características das vítimas de queda da própria altura, principalmente a respeito da frequência de lesões graves, seu diagnóstico e tratamento. MÉTODOS: Estudo retrospectivo dos protocolos de trauma (coletados prospectivamente) de 10/06/2008 a 10/03/2009, incluindo as vítimas de trauma fechado com idade igual ou superior a 13 anos admitidas na sala de emergência. Consideraremos como "graves" as lesões com escore de AIS (Abbreviated Injury Scale) maior ou igual a três. As variáveis foram comparadas entre o grupo de vítimas de quedas da própria altura (Grupo I) e as demais vítimas de trauma fechado (Grupo II). Empregamos os testes T de Student, Qui quadrado e Fisher para a comparação entre os grupos, considerando o valor de p<0,05 como significante. RESULTADOS: Foram analisados 1993 casos de trauma fechado, sendo que 305 (15%) foram vítimas de quedas da própria altura (Grupo I). A média etária nas vítimas de quedas da própria altura foi 52,2 ± 20,9 anos, sendo 64,8% do sexo masculino. Noventa e oito (32,1%) tinham idade acima de 60 anos. No grupo I, as lesões em segmento cefálico foram as mais encontradas (62,2%), seguidas das lesões em extremidades (22,3%), torácicas (1,3%) e abdominais (0,7%). As lesões graves (AIS>3) foram mais frequentemente observadas em segmento cefálico (8,9%), seguidas pelas lesões em extremidades (4,9%). A craniotomia foi necessária em 2,3% das vítimas de quedas de própria altura. Observamos que, em comparação às vítimas de outros mecanismos de trauma fechado, as vítimas de quedas da própria altura apresentavam, significantemente (p<0,05), maior média etária, maior média de pressão arterial sistólica à admissão e maior média de AIS em segmento cefálico bem como menor média de ISS, de AIS em tórax, de AIS em abdome e AIS em extremidades. CONCLUSÃO: A valorização do mecanismo de trauma nas vítimas de quedas da própria altura é de extrema importância, visto a possibilidade de haver lesões graves e clinicamente ocultas, principalmente em segmento cefálico.

OBJECTIVE: Assess characteristics of trauma patients who sustained falls from their own height, more specifically focusing on presence of severe injuries, diagnosis and treatment. METHODS: Retrospective study including all adult blunt trauma patients admitted in the emergency room in a period of 9 months. Lesions with AIS (Abbreviated Injury Scale)>3 were considered "severe". Variables were compared between victims of fall from their own height (group I) and other blunt trauma mechanisms (group II). Student's t, chi square and Fisher exact tests were used for statistical analysis, considering p<0.05 as significant. RESULTS: Of the 1993 trauma patients included, 305 (15%) were victims of falls from their own height. In group I, mean age was 52.2 ± 20.8 years and 64.8% were male. Injuries in the head segment were the most frequently observed (62.2%), followed by injuries in the extremities (22.3%), thorax (1.3%) and abdomen (0.7%). Severe injuries (AIS>3) were more frequent in the head (8.9%), followed by extremities (4,9%). In group I, craniotomies were needed in 2.3%. By comparing groups, we observed that victims of falls from their own height had significantly higher mean age, higher mean systolic blood pressure, and higher head AIS mean, as well as lower ISS mean, thorax AIS mean, abdomen AIS mean and extremities AIS mean. CONCLUSION: Importance of the trauma mechanism in victims of falls from own height should be emphasized due to a considerable possibility of occult severe injuries, mainly in the cephalic segment.