RESUMO. COVID-19 é uma doença infecciosa declarada pela Organização Mundial da Saúde como emergência de saúde pública de interesse internacional. Objetivo: O objetivo deste artigo é determinar as condições de saúde física, psicológica, social e de humor na quarentena de COVID-19 em adultos com comprometimento cognitivo leve. Métodos: A amostra foi composta de 129 participantes, a maioria saudável, mas alguns com comprometimento cognitivo leve. Os dados foram coletados por meio de questionário e da escala de depressão geriátrica de Yesavage, aplicada por meio de ligações telefônicas no período de abril a junho de 2020. Resultados: Diferenças estatisticamente significantes foram encontradas nas mudanças nos hábitos de sono dos participantes saudáveis (p=0,018). As comparações intragrupo da escala de depressão geriátrica de Yesavage em participantes saudáveis foram significativas (p=0,010) e, no nível intergrupo, antes e depois da quarentena mostraram diferenças significativas nos escores do pré-teste (p=0,003). Conclusões: O isolamento social teve efeito psicológico negativo sobre os hábitos de sono, humor deprimido e saúde física, principalmente em participantes saudáveis.

ABSTRACT. COVID-19 is an infectious disease declared by the World Health Organization as a public health emergency of international concern. Objective: The objective of this article was to determine the physical, psychological, and social health conditions and mood of COVID-19 quarantine in adults with mild cognitive impairment. Methods: The sample consisted of 129 participants, most of them were healthy, but some have mild cognitive impairment. The data were collected with a questionnaire and the Yesavage Geriatric Depression Scale applied through phone calls from April to June 2020. Results: Statistically significant differences were found in the changes in sleep habits of the healthy participants (p=0.018). Intragroup comparisons of the Yesavage Geriatric Depression Scale in healthy participants were significant (p=0.010) and at the intergroup level before and after quarantine showed significant differences in pretest scores (p=0.003). Conclusions: Social isolation had a negative psychological effect on sleep habits, depressed mood, and physical health, mainly in healthy participants.

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects 50% of people over 85 years of age and is one of the most common in adulthood and the most common cause of dementia in developed countries. The objective was to determine which have been the most studied cognitive, biological, anatomical and behavioral markers of mild cognitive impairment (MCI) and AD in the last 10 years. Observational studies were searched in the Scopus, Pubmed and Sciencedirect databases. 187 articles were identified, of which 23 with full text were finally selected. The studies corresponded to cognitive (15 studies), biological (8 studies), anatomical (3 studies) and behavioral (2 studies) markers. The identified markers will help guide the design of early detection programs and future interventions that reduce neuropathological effects and significant alterations in quality of life.

Resumen La enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa progresiva que afecta el 50 % de las personas mayores de 85 años y es una de las más comunes en la edad adulta y la causa más frecuente de demencia en los países desarrollados. El objetivo fue determinar cuáles han sido los marcadores cognitivos, biológicos, anatómicos y conductuales del deterioro cognitivo leve (DCL) y la EA más estudiados en los últimos 10 años. Se buscaron estudios en las bases de datos Scopus, Pubmed y Sciencedirect. Se identificaron 187 artículos, de los que finalmente se seleccionaron 23 con texto completo. Los estudios correspondieron a marcadores cognitivos (15 estudios), biológicos (8 estudios), anatómicos (3 estudios) y conductuales (2 estudios). Los marcadores identificados permitirán orientar el diseño de programas de detección temprana y futuras intervenciones que disminuyan los efectos neuropatológicos y las alteraciones significativas en la calidad de vida.