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Abstract Objectives Hospitalization during pregnancy and childbirth increases the risk of Venous Thromboembolism Risk (VTE). This study applied a VTE risk score to all hospitalized pregnant women to ascertain its effectiveness in preventing maternal death from VTE until 3 months after discharge. Methods In this interventional study, patients were classified as low- or high-risk according to the VTE risk score (Clinics Hospital risk score). High-risk patients (score ≥ 3) were scheduled for pharmacological Thromboprophylaxis (TPX). Interaction analysis of the main risk factors was performed using Odds Ratio (OR) and Poisson regression with robust variance. Results The data of 10694 cases (7212 patients) were analyzed; 1626 (15.2%, 1000 patients) and 9068 (84.8%, 6212 patients) cases were classified as high-risk (score ≥ 3) and low-risk (score < 3), respectively. The main risk factors (Odds Ratio, 95% Confidence Interval) for VTE were age ≥ 35 and < 40 years (1.6, 1.4-1.8), parity ≥ 3 (3.5, 3.0-4.0), age ≥ 40 years (4.8, 4.1-5.6), multiple pregnancies (2.1, 1.7-2.5), BMI ≥ 40 kg/m2 (5.1, 4.3-6.0), severe infection (4.1, 3.3-5.1), and cancer (12.3, 8.8-17.2). There were 10 cases of VTE: 7/1636 (0.4%) and 3/9068 (0.03%) in the high- and low-risk groups, respectively. No patient died of VTE. The intervention reduced the VTE risk by 87%; the number needed to treat was 3. Conclusions This VTE risk score was effective in preventing maternal deaths from VTE, with a low indication for TPX. Maternal age, multiparity, obesity, severe infections, multiple pregnancies, and cancer were the main risk factors for VTE. . (VTE) discharge highrisk high Clinics score. score) Highrisk High TPX (TPX) OR (OR variance 1069 7212 (721 analyzed 162 15.2%, 152 15 2 (15.2% 100 906 84.8%, 848 84 8 (84.8% 621 lowrisk 3, , respectively 95 Interval 4 1.6, 16 1 6 (1.6 1.41.8, 1418 1.4 1.8 1.4-1.8) 3.5, 5 (3.5 3.04.0, 3040 3.0 4.0 0 3.0-4.0) 4.8, 48 (4.8 4.15.6, 4156 4.1 5.6 4.1-5.6) 2.1, 21 (2.1 1.72.5, 1725 1.7 2.5 7 1.7-2.5) kgm2 kgm kg m2 m kg/m 5.1, 51 (5.1 4.36.0, 4360 4.3 6.0 4.3-6.0) 4.1, 41 (4.1 3.35.1, 3351 3.3 5.1 3.3-5.1) 12.3, 123 12 (12.3 8.817.2. 88172 8.8 17.2 17 8.8-17.2) 71636 1636 7/163 0.4% 04 (0.4% 39068 3/906 0.03% 003 03 (0.03% groups 87% 87 multiparity obesity infections (VTE (TPX 106 721 (72 15.2% (15.2 90 84.8% (84.8 62 9 1.6 (1. 1.41.8 141 14 1. 18 1.4-1.8 3.5 (3. 3.04.0 304 30 4. 3.0-4.0 4.8 (4. 4.15.6 415 56 5. 4.1-5.6 2.1 (2. 72 1.72.5 172 25 2. 1.7-2.5 (5. 36 4.36.0 436 43 60 6. 4.3-6.0 3.35.1 335 33 3.3-5.1 12.3 (12. 817 8.817.2 8817 88 8. 17. 8.8-17.2 7163 163 7/16 0.4 (0.4 3906 3/90 0.03 00 (0.03 (7 15.2 (15. 84.8 (84. (1 1.41. 1.4-1. (3 3.04. 3.0-4. (4 4.15. 4.1-5. (2 1.72. 1.7-2. (5 4.36. 4.3-6. 3.35. 3.3-5. 12. (12 81 8.817. 881 8.8-17. 716 7/1 0. (0. 390 3/9 0.0 (0.0 ( 15. (15 84. (84 1.41 1.4-1 3.04 3.0-4 4.15 4.1-5 1.72 1.7-2 4.36 4.3-6 3.35 3.3-5 8.817 8.8-17 71 7/ (0 39 3/ (8 1.4- 3.0- 4.1- 1.7- 4.3- 3.3- 8.81 8.8-1 8.8-