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Technological Prospection and Scientific Innovation of Ilex paraguariensis Saint-Hilaire in the Wound Healing Process SaintHilaire Saint Hilaire
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Clemente, Pedro Augusto

; Mendonça, Kelby Cavalheiro

; Andrade, Giovana Frazon de

; Goncalves, Larisse Medeiros

; Godoy, Cristiane Maria Tonetto

; Rocha, Jhonatan Matheus Piaceski

; Silva, Weber Claudio Francisco Nunes da

; Reolon, Jéssica Brandão

; Ferreira, Daiane Finger

; Vieira, Maria Cristina Umpierrez

; Silva, Juliana Maria

; Ferreira, Luana Mota

; Bonini, Juliana Sartori

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230086

Abstract: En | Text: En | PDF: En

Abstract Natural compounds are possible alternatives for wound treatment, including Ilex paraguariensis, a plant with several pharmacological actions already reported, including anti-inflammatory, antibacterial, antioxidant, and healing activities. Therefore, this study aimed to perform a technological and scientific mapping of Ilex paraguariensis used for healing and/or analgesic purposes. Technological prospection was carried out in the Questel-Orbit system, while the scientific research was carried out in PubMed, Web of Science, and SCOPUS databases. The terms “Ilex paraguariensis”, “Yerba-mate”, “Painkiller”, “Analgesic”, “Wound”, “Healing”, and “Scar” were combined using Boolean operators “OR” and “AND”. The technological prospection resulted in 164 patents found initially. After sorting the abstracts, five patents were read entirely, of which three were selected. Such selected patents report using Ilex paraguariensis for analgesics, wound healing, personal care, and pharmaceutical applications. In addition, the scientific research showed a small number of studies aimed at using Ilex paraguariensis for healing and/or analgesic purposes. Among the 26 articles initially found, only 5 met the inclusion requirements. Scientific studies demonstrate that Ilex paraguariensis is used as an extract or drink, presenting promising results regarding analgesia, inflammation, and wound healing, using in vitro or in vivo models. Despite the potential of Ilex paraguariensis in skin wound therapy, our study demonstrates that few patents and scientific studies explore Ilex paraguariensis for this purpose. This fact may be an incentive for the development of further studies employing Ilex paraguariensis in cutaneous wound management and the pain associated with them. treatment reported antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory antibacterial antioxidant activities Therefore andor purposes QuestelOrbit Questel Orbit system PubMed Science databases , paraguariensis” Yerbamate, Yerbamate Yerba mate “Yerba-mate” Painkiller, Painkiller “Painkiller” Analgesic, Analgesic “Analgesic” Wound, Wound “Wound” Healing, Healing “Healing” Scar “Scar OR “OR AND. AND . “AND” 16 abstracts entirely analgesics care applications addition 2 requirements drink analgesia inflammation models therapy purpose them “Yerba-mate “Painkiller “Analgesic “Wound “Healing “AND 1

https://doi.org/10.1590/1678-4324-2024230086

Food Introduction and Its Implications on the Development of Celiac Disease in Childhood
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Oliveira, Giovanna Tardem

; Rocha Junior, Odonis

; Ferreira, Luana Mota

; Reolon, Jéssica Brandão

; Bonini, Juliana Sartori

; Sari, Marcel Henrique Marcondes

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230928

Abstract: En | Text: En | PDF: En

Abstract This study investigated the relationship between food introduction and celiac disease development. This bibliographic review was conducted from May to June 2023 and covered publications from 2013 to 2023. The Virtual Health Library (VHL) and PubMed databases were used, with the following search terms: “Celiac Disease,” “Gluten enteropathy” (with the Boolean operator “OR”), “Infant,” “Preschooler” (also using the Boolean operator “OR”) and “Food Introduction.” A total of 28 articles were found and, after careful analysis, only 6 met the inclusion and exclusion criteria. These articles addressed topics such as the relationship between dietary patterns and the risk of celiac disease, the prevalence of the disease in children born before and after the epidemic in Sweden, the feasibility of introducing allergens and their relationship with breastfeeding, and the implications of introducing gluten into the diet and early weaning in celiac disease. The results of the study highlight the importance of further research into this topic to develop possible methods of prevention and intervention in the manifestation process of celiac disease. From the bibliographic review, it was possible to identify the variables that imply the development of celiac disease and refute the hypotheses of the direct influence of the early introduction of gluten in the diet on the manifestation of the disease. 202 201 VHL (VHL used terms Celiac Disease, Disease Gluten enteropathy OR, OR , Infant, Infant “Infant, Preschooler “Preschooler also “OR” Food Introduction. Introduction 2 analysis criteria Sweden breastfeeding 20 “Infant “OR

https://doi.org/10.1590/1678-4324-2024230928

Predictive Modeling of Rheological Behavior in Semisolid Pharmaceutical Formulations Using Computational Tools. Tools
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Reolon, Jéssica Brandão

; Hammerschmitt, Bruno Knevitz

; Sari, Marcel Henrique Marcondes

; Lazo, Raul Edison Luna

; Cobre, Alexandre de Fátima

; Capeletti, Marcelo Bruno

; Rigo, Maurício

; Bonini, Juliana Sartori

; Abaide, Alzenira da Rosa

; Pontarolo, Roberto

; Ferreira, Luana Mota

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24240050

Abstract: En | Text: En | PDF: En

Abstract Topical treatments for skin conditions offer significant benefits, yet understanding the rheological characteristics of semi-solid formulations is crucial, as they directly influence treatment adherence through their applicability. Ideally, these formulations should maintain their placement at the application site and facilitate easy spreading without requiring excessive force, particularly on painful lesions. In this study, a Python-based tool was developed to assess the rheological behavior of formulations, with a gel-cream serving as a model to demonstrate its applicability. The model formulation was created by emulsifying an oily phase, including blackcurrant oil, with an aqueous phase containing xanthan gum as a gelling agent. Rheological parameters were determined using a rotational viscometer. The prepared gel-cream exhibited pseudoplastic behavior, with viscosity decreasing as rotation speed increased. The Python tool was utilized to extract information about the rheological properties of the samples. Upon applying the data to various mathematical models, it was confirmed that the formulations displayed pseudoplasticity, with the Ostwald-de-Waele model demonstrating the best fit for all evaluated formulations. This pseudoplastic behavior was further confirmed by calculating the flow index (ɳ), which was found to be lower than 1. Open-source tools are gaining popularity across various industries due to their transparency, collaborative nature, and cost-effectiveness. They enable users to enhance product properties, explore therapeutic targets, facilitate efficient collaboration, develop customized software, create predictive models, and ensure regulatory compliance. Our study offers a precise solution for determining the rheological behavior of semi-solid formulations while mitigating human estimation errors. However, it's important to note that proficiency in programming is required to utilize this tool effectively. benefits semisolid semi solid crucial applicability Ideally force lesions Pythonbased based gelcream gel cream oil agent viscometer increased samples models pseudoplasticity OstwalddeWaele Ostwald de Waele ɳ, ɳ , (ɳ) 1 Opensource Open source transparency nature costeffectiveness. costeffectiveness cost effectiveness. effectiveness cost-effectiveness targets collaboration software compliance errors However s effectively (ɳ

https://doi.org/10.1590/1678-4324-2024240050

Effects of neurofeedback on major depressive disorder: a systematic review disorder
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Dobbins, Isabelly Cristine de Souza

; Bastos, Murilo

; Ratis, Renan Cassiano

; Silva, Weber Claúdio Francisco Nunes da

; Bonini, Juliana Sartori

einstein (São Paulo)

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2023, Volume 21 elocation eRW0253

Abstract: En | Text: En | PDF: En

ABSTRACT Background Major depressive disorder is a difficult-to-treat psychological disorder. Approximately 30% of patients with major depressive disorder do not respond to conventional therapies; thus, the efficacy of alternative therapies for treating major depressive disorder, such as neurofeedback, a non-invasive neuromodulation method used in the treatment of psychiatric diseases, must be investigated. Objective We aimed to evaluate the efficacy of neurofeedback in minimizing and treating major depressive disorder and its application as a substitute to or an adjuvant with conventional therapies. Methods We searched for experimental studies published between 1962–2021 in Scopus, PubMed, Web of Science, and Embase databases and identified 1,487 studies, among which 13 met the inclusion exclusion criteria. Results We noted that not all patients responded to neurofeedback. Based on depression scales, major depressive disorder significantly improved in response to neurofeedback only in a few individuals. Additionally, the number of training sessions did not influence the results. Conclusion Neurofeedback can reduce depression symptoms in patients; however, not all patients respond to the treatment. Therefore, further studies must be conducted to validate the effectiveness of neurofeedback in treating major depressive disorder. difficulttotreat difficult treat 30 thus noninvasive non invasive diseases investigated 19622021 1962 2021 1962–202 Scopus PubMed Science 1487 1 487 1,48 criteria scales individuals Additionally results however Therefore 3 1962202 196 202 1962–20 148 48 1,4 196220 19 20 1962–2 14 4 1, 19622 2 1962–

https://doi.org/10.31744/einstein_journal/2023rw0253

Association between cognitive performance and sarcopenic obesity in older adults with Alzheimer’s disease
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Cavazzotto, Timothy Gustavo

; Campos, Caroline do Valle de

; Mazur, Caryna Eurich

; Silva, Danilo Fernandes da

; Valério, Juliana Maria Silva

; Vieira, Edgar Ramos

; Silva, Weber Claudio Francisco Nunes da

; Bonini, Juliana Sartori

Dementia & Neuropsychologia

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mar 2022, Volume 16 N. 1 Pages 28 - 32

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO. A obesidade sarcopênica (SO), coocorrência de sarcopenia e obesidade, está associada à perda funcional, à fragilidade e à incapacidade em idosos. Recentemente, verificou-se que a SO está associada ao desempenho cognitivo reduzido em adultos. No entanto, não foram feitos estudos de SO em idosos com doença de Alzheimer (AD). Objetivo: Verificar a ocorrência de obesidade sarcopênica e fatores associados em 43 adultos idosos com doença de Alzheimer. Métodos: Aplicamos o miniexame do estado mental (MEEM) e a avaliação clínica da demência (CDR). A SO foi verificada utilizando a absorciometria de dupla emissão de raios X. Resultados: Foram classificadas cinco idosas com SO. As mulheres idosas tinham maior gordura corporal e menor massa muscular em comparação com os homens. Houve relação significativa, ajustada por idade e educação, entre gordura corporal e desempenho cognitivo apenas nos homens (r=0,65; p<0,01). Os homens com obesidade e com mais de 75 anos tiveram melhor desempenho cognitivo em comparação com os homens não obesos <75 anos (p=0,010) e com as mulheres com obesidade >75 anos (p=0,033). Conclusões: As mulheres com AD tinham maior gordura corporal e menor massa muscular do que os homens. A SO ocorreu em mulheres mais velhas com AD. Os homens com maior gordura corporal apresentaram melhor desempenho cognitivo, independentemente da idade e da educação.

ABSTRACT. Sarcopenic obesity (SO), the co-occurrence of sarcopenia and obesity, is associated with functional loss, frailty, and incapacity in older adults. Recently, SO was associated with reduced cognitive performance in adults. However, no SO studies have been done with older adults with Alzheimer’s disease (AD). Objective: The objective of this study was to verify the occurrence of SO and associated factors in 43 older adults with AD. Methods: We applied the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). SO was verified by using dual-emission X-ray absorptiometry. Results: We found five women with SO. Women had higher body fat and lower muscle mass compared with men. There was a significant relationship between body fat and cognitive performance only in men (r=0.65; p<0.01) adjusted by age and education. Men with obesity and aged >75 years had better cognitive performance compared with non-obese men aged <75 years (p=0.010) and women with obesity aged >75 years (p=0.033). Conclusions: Women with AD had higher body fat and lower muscle mass than men. SO occurs in older women with AD. Men with higher body fat showed better cognitive performance, independent of age and education.

https://doi.org/10.1590/1980-5764-dn-2021-0039

Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease
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Schwab, Eduarda Dal Pisol

; Queiroz, Ruliam

; Fiebrantz, Anne Karine Bosetto

; Bastos, Murilo

; Bonini, Juliana Sartori

; Silva, Weber Cláudio Francisco Nunes da

einstein (São Paulo)

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2022, Volume 20 elocation eRW0170

Abstract: En | Text: En | PDF: En

Abstract Alzheimer’s disease is a neurodegenerative condition that causes changes in memory and cognition, in addition to behavioral disorders, and most commonly affects the elderly. Several studies in the literature have presented therapeutic measures in an attempt to interfere with the pathogenic mechanisms of the disease and to mitigate its clinical manifestations. Some factors, such as excitotoxicity, cholinergic dysfunctions, oxidative stress, tau protein hyperphosphorylation, changes in amyloid-beta peptide metabolism, herpes viruses, apolipoprotein E, glycogen synthase kinase 3, insulin resistance, and the endocannabinoid system seem to be related to pathophysiology of Alzheimer’s disease. Given this, a literature review was carried out to address the molecular mechanisms associated with the pathophysiological hypotheses previously mentioned, aiming to better understanding their underlying causes and contributing to possible pharmacological strategies about treatment of the disease.

https://doi.org/10.31744/einstein_journal/2022rw0170

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200452

Abstract: En | Text: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study
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Gregório, Elizama de

; Patrzyk, Luan Henrique

; Fiebrantz, Anne Karine Bosetto

; Bonini, Juliana Sartori

; Cambruzzi, Dayanna Hartmann

; Diedrich, Camila

; Fermino, Bárbara Luisa

; Fabbri, Roberta

; Silva, Weber Cláudio Francisco Nunes da

Revista da Associação Médica Brasileira

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feb 2019, Volume 65 N. 2 Pages 222 - 231

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO: Foram estudados os usuários do programa de distribuição de medicamentos especializados da rede pública de saúde de Guarapuava, Paraná, Brasil. MÉTODOS: Uma coorte prospectiva, em que os idosos foram examinados em dois momentos, com um intervalo de três anos, com 30 pacientes na fase I e 16 na fase II. A metodologia foi composta por visitas domiciliares, avaliação antropométrica; avaliação nutricional e hematológica. Para a progressão da DA, utilizou-se a escala Clinical Demential Rating (CDR). Os testes de Shapiro-Wilk, teste de Wilcoxon e correlações com associações (Δ%), p < 0,05 para as análises estatísticas. RESULTADOS: A progressão da doença, segundo o CDR, evoluiu, pois, em 2014, a maioria dos pacientes encontrava-se em CDR 3. Na análise dos micronutrientes, somente as vitaminas do complexo B (B1, B2, B3, B5, B6) apresentaram redução significativa em 2014. O consumo de carboidratos e lipídeos aumentou na avaliação de 2014, e o consumo de proteínas diminuiu. Quanto ao peso médio dos idosos, houve um aumento em 2014, 65,9 (± 15,6) kg, com IMC 26,75 (± 4, 5); em 2011, o peso médio foi 62,44 kg (± 14,36), IMC 24,64 (± 4,97). CONCLUSÃO: Não foram encontrados pacientes anêmicos ou desnutridos na amostra. A hipótese de que os pacientes provavelmente já apresentavam sobrepeso ou obesidade antes do desenvolvimento da DA, e que isso pode estar associado com um aumento de risco de demência, pode ser sugerida.

SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested.

https://doi.org/10.1590/1806-9282.65.2.222 2016 downloads

Evaluation of dysphagia risk, nutritional status and caloric intake in elderly patients with Alzheimer's
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Goes, Vanessa Fernanda

; Mello-Carpes, Pâmela Billig

; Oliveira, Lilian Oliveira de

; Hack, Jaqueline

; Magro, Marcela

; Bonini, Juliana Sartori

Revista Latino-Americana de Enfermagem

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apr 2014, Volume 22 N. 2 Pages 317 - 324

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

OBJETIVO: avaliar o risco de disfagia e sua relação com o estágio da doença de Alzheimer, bem como a relação entre o risco de disfagia, o estado nutricional e a ingestão calórica em idosos com doença de Alzheimer.MÉTODOS: a amostra foi constituída por 30 indivíduos de ambos os sexos, com diagnóstico provável de doença de Alzheimer. O estágio da doença, o estado nutricional, a ingestão energética e risco de disfagia foram avaliados.RESULTADOS: verificou- se que maior risco de disfagia está associado ao avanço das fases da doença de Alzheimer e mesmo os pacientes nos estágios iniciais da doença apresentam leve risco de desenvolvimento de disfagia. Não foi encontrada associação entre o estado nutricional e o risco de disfagia. Altos níveis de ingestão inadequada de micronutrientes em pacientes também foram observados.CONCLUSÃO: identificou-se associação entre disfagia e desenvolvimento da doença de Alzheimer. Os achados desta pesquisa apontam para a necessidade de monitorar a presença de disfagia e da ingestão de micronutrientes em pacientes com doença de Alzheimer.

OBJECTIVE: to evaluate the risk of dysphagia and its relationship with the stage of Alzheimer's Disease, as well as the relationship between the risk of dysphagia and nutritional status and caloric intake in elderly people with Alzheimer's disease.METHODS: the sample consisted of 30 subjects of both genders with probable Alzheimer's disease. The stage of the disease, nutritional status, energy intake, and risk of dysphagia were assessed.RESULTS: it was found that increased risk of dysphagia is associated with the advance in the stages of Alzheimer's disease and that even patients in the early stages of disease have a slight risk of developing dysphagia. No association was found between nutritional status and the risk of dysphagia. High levels of inadequate intake of micronutrients were also verified in the patients.CONCLUSION: an association between dysphagia and the development of Alzheimer's disease was found. The results indicate the need to monitor the presence of dysphagia and the micronutrient intake in patients with Alzheimer's disease.

OBJETIVO: evaluar el riesgo de la disfagia y su relación con la etapa de la enfermedad de Alzheimer, así como la relación del riesgo de la disfagia y el estado nutricional y la ingesta calórica en los ancianos con enfermedad de Alzheimer.MÉTODOS: la muestra consistió en 30 sujetos de ambos sexos con probable enfermedad de Alzheimer. Se evaluó la etapa de la enfermedad, el estado nutricional, la ingesta de energía y el riesgo de disfagia.RESULTADOS: se encontró que un mayor riesgo de disfagia está asociado con el avance en las etapas de la enfermedad de Alzheimer e incluso los pacientes en las primeras etapas de la enfermedad tienen un ligero riesgo de desarrollar disfagia. No se encontró asociación entre el estado nutricional y el riesgo de disfagia. También verificamos los altos niveles de ingesta insuficiente de micronutrientes en los pacientes.CONCLUSIÓN: se encontró una asociación entre la disfagia y el desarrollo de la enfermedad de Alzheimer. Nuestros resultados apuntan a la necesidad de monitorear la presencia de disfagia y la ingesta de micronutrientes en pacientes con enfermedad de Alzheimer.

https://doi.org/10.1590/0104-1169.3252.2418 28561 downloads

10.

Evaluation of dysphagia risk, nutritional status and caloric intake in elderly patients with Alzheimer's
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Goes, Vanessa Fernanda

; Mello-Carpes, Pâmela Billig

; Oliveira, Lilian Oliveira de

; Hack, Jaqueline

; Magro, Marcela

; Bonini, Juliana Sartori

Revista Latino-Americana de Enfermagem

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apr 2014, Volume 22 N. 2 Pages 317 - 324

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0104-1169.3252.2418 4 downloads

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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