Resumo Introdução: Pesquisa multicêntrica em centros de diálise brasileiros são escassas. Descrevemos as fases de recrutamento e implementação do estudo SARC-HD, visando investigar a sarcopenia e seu impacto em desfechos clínicos adversos. Métodos: O SARC-HD é um estudo de coorte realizado com pacientes em hemodiálise no Brasil. A fase de recrutamento foi considerada o período entre convite ao centro e início da inclusão de pacientes, enquanto a fase de implementação durou a partir de então até a conclusão do recrutamento e coleta de dados basais. Após a implementação, um questionário estruturado foi distribuído para coletar feedback dos principais pesquisadores. Resultados: 21 centros de três regiões brasileiras consentiram em participar, com duas desistências. Dez pesquisadores principais supervisionaram 19 locais. Nove centros (47%) eram totalmente financiados por planos de saúde. 1525 pacientes foram avaliados para elegibilidade e 1008 foram incluídos, com taxa de recrutamento de 66,1%. Recrutamento e coleta de dados basais levaram 12 semanas [intervalo interquartil: 5–15]. A análise qualitativa de conteúdo identificou barreiras como falta de infraestrutura e logística para pesquisa. Os facilitadores incluíram gestão e organização do comitê gestor. Os desafios da coleta de dados foram relatados principalmente quanto à avaliação global subjetiva de 7 pontos e o questionário internacional de atividade física. O principal desafio para a fase de manutenção será a falta de informações padronizadas nos prontuários eletrônicos. Conclusões: As fases de recrutamento e implementação do estudo multicêntrico SARC-HD foram viáveis. Barreiras e facilitadores identificados pelos pesquisadores principais podem auxiliar futuras iniciativas multicêntricas a integrar tarefas relacionadas à pesquisa na rotina clínica, facilitando experiências bem-sucedidas. Introdução escassas SARCHD, SARCHD SARC HD, HD adversos Métodos Brasil Resultados 2 participar desistências 1 locais 47% 47 (47% saúde 152 100 incluídos 661 66 66,1% intervalo interquartil 5–15. 515 5–15 . 5 15 5–15] gestor física eletrônicos Conclusões viáveis clínica bemsucedidas. bemsucedidas bem sucedidas. sucedidas bem-sucedidas 4 (47 10 6 66,1 51 5–1 (4 66, 5– (

Abstract Introduction: Multicenter research initiatives in Brazilian dialysis centers are scarce. We described the recruitment and implementation phases of the SARC-HD study, aimed at investigating sarcopenia and its impact on adverse clinical outcomes. Methods: The SARC-HD is a cohort study being conducted with patients on hemodialysis in Brazil. The recruitment phase was defined as the period from the invitation to the center until the start of patient enrollment, whereas the implementation phase lasted from then until the completion of enrollment and baseline data collection. Upon implementation, a structured questionnaire was distributed to collect feedback from principal investigators. Results: 21 centers from three Brazilian regions consented to participate, with two dropping out. Ten principal investigators oversaw the 19 sites. Nine centers (47%) were funded entirely by health insurance companies. A total of 1525 patients were screened for eligibility and 1008 were enrolled, with a 66.1% recruitment rate. Recruitment and baseline data collection took 12 [interquartile range: 5–15] weeks. Qualitative content analysis identified barriers such as a lack of infrastructure and logistics for research. Facilitators included the management and organization of the steering committee. Data collection challenges were mainly reported with the subjective 7-point global assessment and the international physical activity questionnaire. The main challenge for the ongoing maintenance phase will be the lack of standardized information in electronic health records. Conclusions: The recruitment and implementation phases of the multicenter SARC-HD study were feasible. Barriers and facilitators identified by principal investigators may help future multicenter initiatives to integrate research-related tasks into clinical routine, facilitating successful experiences. Introduction scarce SARCHD SARC HD outcomes Methods Brazil Results 2 participate out 1 sites 47% 47 (47% companies 152 100 enrolled 661 66 66.1 rate interquartile range 5–15 515 5 15 weeks committee 7point point 7 records Conclusions feasible researchrelated related routine experiences 4 (47 10 6 66. 5–1 51 (4 5– (

Silver nanowires thin films have gained attention due to their excellent optical and electrical properties, being a potential material to be applied in optoelectronic devices as transparent conductive films, deposited on a substrate in a such way that forms a percolated network. We report the synthesis of silver nanowires with average length of 9.5 ± 0.4 µm and diameter of 75 ± 3 nm by a modified polyol method and fabrication of transparent and conductive thin films using a simple and low-cost technique as drop-casting. Additionally, we examined the influence of the drop-casting method in function of number of deposition cycles on the optical and electrical properties of the films through optical absorption and electrical resistance measurements using the two-point methodology. Increasing the number of silver nanowire deposition layers, the optical transmittance decreased from 97 (for one layer) to 60% (for five layers), and electrical resistance decreased from 940 ± 0.35 Ω for the 2-layer film to 32 ± 0.02 Ω, for the 5-layer film. Due to the electrical conductivity range of the produced silver nanowires films, we suggested their application in low-voltage circuits. network 95 9 5 9. 04 0 4 0. 7 lowcost low cost dropcasting. dropcasting drop casting. casting Additionally twopoint two point methodology layers layer 60 , layers) 94 035 35 0.3 2layer 2 002 02 0.0 5layer lowvoltage voltage circuits 6 03 00

ABSTRACT The most common cause of spinal cord injury are high impact trauma, which often result in some motor impairment, sensory or autonomic a greater or lesser extent in the distal areas the level of trauma. In terms of survival and complications due to sequelae, veterinary patients have a poor prognosis unfavorable. Therefore justified the study of experimental models of spinal cord injury production that could provide more support to research potential treatments for spinal cord injuries in medicine and veterinary medicine. Preclinical studies of acute spinal cord injury require an experimental animal model easily reproducible. The most common experimental animal model is the rat, and several techniques for producing a spinal cord injury. The objective of this study was to describe and evaluate the effectiveness of acute spinal cord injury production technique through inflation of Fogarty(r) catheter using rabbits as an experimental model because it is a species that has fewer conclusive publications and contemplating. The main requirements of a model as low cost, handling convenience, reproducibility and uniformity. The technique was adequate for performing preclinical studies in neuro-traumatology area, effectively leading to degeneration and necrosis of the nervous tissue fostering the emergence of acute paraplegia.

Redes de junções Josephson são dispositivos supercondutores com importantes aplicações tanto em tecnologia quanto em ciência básica. Neste artigo mostramos como estes dispositivos funcionam, suas propriedades magnéticas e de transporte, e como através das quais é possível estudar propriedades ainda controversas dos sistemas supercondutores granulares tais como o Efeito Meissner Paramagnético (PME), a Avalanche de Vórtices (VA) e outros efeitos relacionados com a granularidade.

Arrays of Josephson junctions are powerful superconducting devices with both technological and basic applications. In this review article, we describe how these devices work as well as their transport and magnetic properties. We also show how they can be used to explain some of the controversial properties of granular superconducting systems, like Paramagnetic Meissner Effect (PME), Vortex Avalanche (VA) and other granularity-related e ects.