The use of materials such as organofunctionalized silica for application in solid phase extraction (SPE) allows the preconcentration of several ions, including Pt, and subsequent detection. This work aims to synthesize and characterize an organofunctionalized silica (Sil-TMSDT) with the silylant N’(trimethoxysilyl)propylethylenetriamine and its application as a solid phase in the preconcentration Pt4+ ions in aqueous media, using detection by flame atomization atomic absorption spectroscopy (FAAS). The Fourier-transform infrared spectroscopy (FTIR) spectra and scanning electron microscopy (SEM) coupled with energy-dispersive spectroscopy (EDS) confirmed the aminofunctionalization of the silica. For the adsorption process, a preconcentration mini-column with 200 mg of Sil-TMSDT, a solution of 0.485 mg L−1 of K2[PtCl6] at pH 10 and HNO3 0.5 mol L−1 as eluent were used, obtaining an enrichment factor of 15-fold with retention efficiency higher than 99%. The Pt4+ ion determined by FAAS showed a linear response between 0.02 and 0.40 mg L−1; a linear coefficient where R = 0.9981; a 16-fold preconcentration factor; a limit of quantification (LOQ) and limit of detection (LOD) of 0.045 and 0.014 mg L−1, respectively. The proposal system showed analytical applicability to determining Pt4+ ion in an aqueous medium and could be used to detect traces of this potentially toxic metal in biological fluids such as urine and blood. SPE (SPE Pt SilTMSDT Sil TMSDT (Sil-TMSDT Ntrimethoxysilylpropylethylenetriamine N trimethoxysilyl propylethylenetriamine Pt4 media FAAS. . (FAAS) Fouriertransform Fourier transform FTIR (FTIR SEM (SEM energydispersive energy dispersive EDS (EDS process minicolumn mini column 20 SilTMSDT, TMSDT, Sil-TMSDT 0485 0 485 0.48 L1 L 1 L− K2PtCl6 KPtCl K2 PtCl6 K PtCl K2[PtCl6 HNO 05 5 0. 15fold fold 15 99 99% 002 02 0.0 040 40 0.4 0.9981 09981 9981 16fold 16 LOQ (LOQ LOD (LOD 0045 045 0.04 0014 014 0.01 respectively blood (FAAS 2 048 48 K2PtCl K2[PtCl 9 00 04 4 0.998 0998 998 004 001 01 0.99 099 0.9 09

The first step in the synthesis of polyaniline doped with dodecylbenzene sulfonic acid is the synthesis of the anilinium dodecylbenzene sulfonate salt obtained through the reaction between aniline and dodecylbenzene sulfonic acid in aqueous medium. In this work, theoretical models were developed to simulate the formation mechanism of this salt in an aqueous medium. Changes in energy, frontier orbitals, gap energy, charge distribution and thermodynamic parameters were calculated. These theoretical results were correlated with the experimental data from the synthesis of the salt and from infrared spectroscopy. Theoretical models suggested that the solubilization of dodecylbenzene sulfonic acid and aniline in water are energetically and thermodynamically favorable processes. Interactions between the frontier orbitals indicated the formation of water-insoluble anilinium dodecylbenzene sulfonate salt. These molecular modeling results agree with experimental data indicating that the theoretical method used was efficient in simulating the reaction system. medium work energy calculated spectroscopy processes waterinsoluble insoluble system

RESUMO: A leptospirose é uma doença zoonótica que deve ser estudada sob o ponto de vista da Saúde Única. É possível que existam particularidades na epidemiologia da leptospirose no bioma Caatinga, onde o ambiente é muitas vezes desfavorável e desafia a adaptabilidade de Leptospira spp. No total, 100 cães (47 de abrigos e 53 errantes) selecionados com base em cálculo amostral foram utilizados para avaliar a soroprevalência de Leptospira spp. e os fatores associados. O teste de soroaglutinação microscópica (SAM) foi aplicado para detetar anticorpos anti-Leptospira spp. (título 50 como ponto de corte). Os fatores de risco foram identificados utilizando a análise de regressão de Poisson robusta. Vinte e quatro animais (24%; IC 95% = 15,6% - 32,4%) foram soropositivos, os títulos de anticorpos variaram de 50 a 200, e os serogrupos reagentes foram Ballum (17%), Autumnalis (6%) e Djasiman (1%). Os fatores/categorias associados à seropositividade foram o ambiente onde o animal se encontra/solo (razão de prevalência [RP] = 6,03; IC 95% para RP: 1,86 - 7,69; P < 0,001) e o acesso a água poluída/sim (RP = 3,79; IC 95% para RP: 1,85 - 24,22; P = 0,011). Os resultados sugerem a leptospirose como uma preocupação no contexto da Saúde Única em cães errantes e de abrigos no bioma Caatinga, apesar das condições adversas desse bioma para a sobrevivência de Leptospira spp. no ambiente. Além disso, apesar de serem questões sociais e governamentais, fatores como o ambiente onde o animal fica (solo) e o acesso à água poluída devem ser cuidadosamente analisados e corrigidos para evitar a transmissão de leptospiras para animais e humanos. RESUMO Caatinga spp total 10 47 (4 5 SAM (SAM antiLeptospira anti título corte. corte . corte) robusta 24% 24 (24% 95 156 15 6 15,6 32,4% 324 32 4 soropositivos 200 17%, 17 17% , (17%) 6% (6% 1%. 1 1% (1%) fatorescategorias categorias encontrasolo encontra solo razão RP [RP 6,03 603 03 186 86 1,8 7,69 769 7 69 0,001 0001 0 001 poluídasim sim 3,79 379 3 79 185 85 24,22 2422 22 0,011. 0011 0,011 011 0,011) disso governamentais (solo humanos ( 2 (24 9 15, 32,4 20 (17% (6 (1% 6,0 60 18 8 1, 7,6 76 0,00 000 00 3,7 37 24,2 242 0,01 01 (2 32, (17 (1 6, 7, 0,0 3, 24, 0,

ABSTRACT: Leptospirosis is a zoonotic disease that must be studied on the One Health point of view. It is possible that there are particularities in the epidemiology of leptospirosis in Caatinga biome, where the environment is often unfavorable and challenges the adaptability of Leptospira spp. Overall, 100 dogs (47 shelter and 53 stray dogs) selected based on sampling calculation were used to evaluate the Leptospira spp. seroprevalence and associated factors. The microscopic agglutination test (MAT) was applied to detect anti-Leptospira spp. antibodies (cut-off titer 50). Risk factors were identified using the robust Poisson regression analysis. Twenty-four animals (24%; 95% CI = 15.6% - 32.4%) were seroreactive, antibody titers ranged from 50 to 200, and the reacting serogroups were Ballum (17%), Autumnalis (6%) and Djasiman (1%). The factors/categories associated with seropositivity were the environment where the animal stay/soil (prevalence ratio [PR] = 6.03; 95% CI for PR: 1.86 - 7.69; P < 0.001) and access to polluted water/yes (PR = 3.79; 95% CI for PR: 1.85 - 24.22; P = 0.011). The results suggested leptospirosis as a concern in the One Health context in stray and shelter dogs from the Caatinga biome despite the adverse conditions of this biome for the survive of Leptospira spp. on the environment. Moreover, despite being social and government issues, factors such as environment where the animal stay (soil) and access to polluted water must be carefully deemed and corrected to avoid the transmission of leptospires to animals and humans. ABSTRACT view spp Overall 10 47 (4 5 MAT (MAT antiLeptospira anti cutoff cut off 50. . 50) analysis Twentyfour Twenty four 24% 24 (24% 95 156 15 6 15.6 32.4% 324 32 4 seroreactive 200 17%, 17 17% , (17%) 6% (6% 1%. 1 1% (1%) factorscategories categories staysoil soil prevalence PR [PR 6.03 603 03 186 86 1.8 7.69 769 7 69 0.001 0001 0 001 wateryes yes 3.79 379 3 79 185 85 24.22 2422 22 0.011. 0011 0.011 011 0.011) Moreover issues (soil humans ( 2 (24 9 15. 32.4 20 (17% (6 (1% 6.0 60 18 8 1. 7.6 76 0.00 000 00 3.7 37 24.2 242 0.01 01 (2 32. (17 (1 6. 7. 0.0 3. 24. 0.

ABSTRACT The cowpea is a legume that is widely grown in the north-east of Brazil, and which has been gaining ground in other regions of the country. The main producer is the state of Ceará, with a large planted-area, albeit low productivity due to a lack of producer technology and adapted cultivars. The aim of this study was to identify and recommend superior genotypes in terms of adaptability and stability under rainfed and irrigated conditions, in addition to genotypes with reduced grain darkening. To this end, six experiments were conducted in different districts of Ceará (Crato, Pentecoste, Crateús, Madalena, Bela Cruz and Limoeiro do Norte) and one laboratory experiment, to evaluate grain darkening. The experimental design of the field trials was of randomised blocks, with 14 genotypes and 4 replications. The analysis of variance showed a significant effect from the genotypes and environments and their interaction, so GGE Biplot analysis was carried out to evaluate adaptability and stability. To evaluate grain darkening, a completely randomised design was used in a simple factorial scheme with six previously selected genotypes and five different storage times (0, 2, 4, 6 and 8 months). There was a significant effect from the genotypes and storage time. Genotype 1 showed the least darkening, and can be recommended for environments to which it is best adapted (Crato and Crateús). Genotype 9 was considered the most stable for grain yield, and can be more broadly recommended for the semi-arid region of the state of Ceará. northeast north east Brazil country plantedarea, plantedarea planted area, area planted-area cultivars conditions darkening end Crato, Crato Pentecoste Crateús Madalena Norte experiment blocks replications interaction 0, 0 (0 2 months. months . months) time Crateús. Crateús) yield semiarid semi arid (

ABSTRACT Planting is considered one of the most essential steps in coffee growing. Lack of uniformity in planting may compromise future operations. Therefore, verifying planting operations quality is fundamental to optimizing production processes and reducing costs. This study aimed to investigate planting techniques through Statistical Process Control (SPC) and aerial images. Carried out in two areas, managed manually and semi-mechanized in the Bom Jardim Farm (MG - Brazil). Data were collected through Remotely Piloted Aircraft (RPA). Quality control charts and density maps were used to identify variations in distribution and spacing between plants and planting rows. It was found that the planting carried out manually was 4.7% wider than projected due to spacing reduction from 0.5 m to 0.48 m. The semi-mechanized system displayed a deficit of 7% compared to the projected planting system, using 0.55 m between plants. The density map showed the most significant planting alignment variations. Despite displaying lower results than the manual system, the semi-mechanized system improvements are valid for their minimal average variations. Thus, correcting points found outside the limits can increase the efficiency of semi-mechanized planting. growing Therefore costs SPC (SPC images areas semimechanized semi mechanized MG Brazil. Brazil . Brazil) RPA. RPA (RPA) rows 47 4 7 4.7 05 0 5 0. 048 48 0.4 055 55 Thus (RPA 4. 04

RESUMO Objetivo: Avaliar a sazonalidade da bronquiolite aguda no Brasil durante a temporada 2020–2022 e compará-la com a das temporadas anteriores. Métodos: Os dados de incidência de internações por bronquiolite aguda em lactentes <1 ano de idade foram obtidos do Departamento de Informática da base de dados da Saúde Pública Brasileira para o período entre 2016 e 2022. Esses dados também foram analisados por macrorregiões do Brasil (Norte, Nordeste, Sudeste, Sul e Centro-Oeste). Para descrever características sazonais e de tendência ao longo do tempo, utilizamos o Modelo de Médias Móveis Integradas Autorregressivas Sazonais. Resultados: Em comparação com o período pré-COVID-19, a incidência de hospitalizações relacionadas com bronquiolite aguda diminuiu 97% durante as intervenções não farmacológicas (março de 2020 – agosto de 2021), mas aumentou 95% após a flexibilização das intervenções não farmacológicas (setembro de 2021 – dezembro de 2022), resultando no aumento geral de 16%. Durante o período pré-COVID-19, as hospitalizações por bronquiolite aguda seguiram um padrão sazonal, que foi interrompido em 2020–2021, mas recuperaram-se em 2022, com um pico ocorrido em maio, aproximadamente 4% superior ao pico pré-COVID-19. Conclusões: Este estudo ressalta a influência significativa das intervenções contra a COVID-19 nas hospitalizações por bronquiolite aguda no Brasil. A restauração de um padrão sazonal em 2022 sublinha a interação entre as medidas de saúde pública e a dinâmica das doenças respiratórias em crianças pequenas. Objetivo 20202022 2020–202 comparála compará la anteriores Métodos 1 < 201 Norte, Norte (Norte Nordeste Sudeste CentroOeste. CentroOeste Centro Oeste . Centro-Oeste) tempo Sazonais Resultados préCOVID19, préCOVID19 préCOVID pré COVID 19, 19 pré-COVID-19 97 março 202 2021, , 2021) 95 setembro 2022) 16 16% 20202021 2020–2021 recuperaramse recuperaram se maio 4 préCOVID19. 19. Conclusões COVID19 COVID-1 pequenas 2020202 2020–20 20 Centro-Oeste préCOVID1 pré-COVID-1 9 COVID1 COVID- 202020 2020–2 2 pré-COVID- 20202 2020– pré-COVID

ABSTRACT Objective: To evaluate the seasonality of acute bronchiolitis in Brazil during the 2020–2022 season and compare it with the previous seasons. Methods: Data from the incidence of hospitalizations due to acute bronchiolitis in infants <1 year of age were obtained from the Department of Informatics of the Brazilian Public Health database for the period between 2016 and 2022. These data were also analyzed by macro-regions of Brazil (North, Northeast, Southeast, South, and Midwest). To describe seasonal and trend characteristics over time, we used the Seasonal Autoregressive Integrated Moving Averages Model. Results: Compared to the pre-COVID-19 period, the incidence of hospitalizations related to acute bronchiolitis decreased by 97% during non-pharmacological interventions (March 2020 – August 2021) but increased by 95% after non-pharmacological interventions relaxation (September 2021 – December 2022), resulting in a 16% overall increase. During the pre-COVID-19 period, hospitalizations for acute bronchiolitis followed a seasonal pattern, which was disrupted in 2020–2021 but recovered in 2022, with a peak occurring in May, approximately 4% higher than the pre-COVID-19 peak. Conclusions: This study underscores the significant influence of COVID-19 interventions on acute bronchiolitis hospitalizations in Brazil. The restoration of a seasonal pattern in 2022 highlights the interplay between public health measures and respiratory illness dynamics in young children. Objective 20202022 2020–202 seasons Methods 1 < 201 macroregions macro regions North, North (North Northeast Southeast South Midwest. Midwest . Midwest) time Model Results preCOVID19 preCOVID pre COVID 19 pre-COVID-1 97 nonpharmacological non pharmacological March 202 95 September , 2022) 16 increase 20202021 May 4 Conclusions COVID19 COVID-1 children 2020202 2020–20 20 preCOVID1 pre-COVID- 9 COVID1 COVID- 202020 2020–2 2 pre-COVID 20202 2020–

Groundwater is considered an important source of water aid for human consumption. However, this water can be contaminated by impurities, such contamination spots that might reach the water tables. The aim of this study was to investigate the quality of shallow groundwater in Flores neighborhood, located in the municipality of Benevides, within Belém metropolitan region, State of Pará, Brazil. Recommendations described in Standard Methods for Examination of Water and Wastewater were followed at the time to determine physical-chemical parameters such as potential hydrogen (pH), electrical conductivity (EC), total dissolved solids (TDS), apparent color, turbidity, total hardness (TH), ions and trace elements. Multivariate statistical analysis has shown that most predictive water-quality parameters set for human consumption are associated with natural events involving weathering and leaching processes. Nevertheless, parameters of nitrate, phosphate, EC, TDS and pH are also influenced by anthropic conditions in the surroundings, mainly phosphate and nitrate ions. Therefore, it can be concluded that shallow groundwaters in Flores neighborhood are unsuitable for human consumption, making it necessary for municipal public authorities to take action to solve the problem of water shortage in the borough, thus preventing the population from use those shallow groundwaters, as their consumption can bring health problems. However impurities tables Benevides region Pará Brazil physicalchemical physical chemical pH, , (pH) EC (EC) TDS, (TDS) color turbidity TH, TH (TH) elements waterquality processes Nevertheless surroundings Therefore borough problems (pH (EC (TDS (TH

RESUMO: O uso de métodos não destrutivos e de baixo custo para determinação de área foliar tem ganhado importantes aplicações. Os objetivos da pesquisa foram (i) propor um método não destrutivo para estimar a área foliar da cultura da mamona e (ii) construir equações que estimem com precisão e rapidez a área foliar da espécie. Foram coletadas mil folhas sadias e expandidas de cinco cultivares de mamona (New Zealand Purple, Sipeal, Carmencita, Amarelo de Irecê e IAC-80), sendo coletadas 200 folhas de cada uma. O comprimento máximo, largura máxima e área foliar foram calculados para cada folha. Foi calculado o produto entre comprimento e largura (LW). Foram realizados testes com diferentes modelos de regressão linear e não linear entre área foliar e dimensões lineares das folhas de cada cultivar. Os modelos utilizados foram linear, linear sem intercepto e potência. Os critérios para escolha dos melhores modelos para estimar a área foliar da mamona foram maior coeficiente de determinação, maior coeficiente de correlação linear de Pearson, menor critério de informação de Akaike, maior índice de concordância de Willmott e menor raiz do erro quadrático médio. As equações que apresentaram melhores critérios para estimativa da área foliar das cultivares de mamona foram aquelas que utilizaram o produto entre comprimento e largura, em comparação às equações que utilizaram apenas uma dimensão foliar. O modelo ŷ = 0,439 × LW pode ser utilizado para estimar com precisão e rapidez a área foliar da mamona por meio de medidas lineares das folhas, utilizando o produto entre comprimento e largura (LW), independente da cultivar escolhida. RESUMO aplicações i (i ii (ii espécie New Purple Sipeal Carmencita IAC80, IAC80 IAC 80 , IAC-80) 20 máximo folha LW. . (LW) potência Pearson Akaike médio 0439 0 439 0,43 LW, escolhida IAC8 8 IAC-80 2 (LW 043 43 0,4 IAC-8 04 4 0, IAC-

ABSTRACT: Using non-destructive and low-cost methods to determine leaf area has gained important applications. The research objectives were (i) to propose a non-destructive method to estimate the leaf area of castor bean crops and (ii) to build equations that accurately and quickly estimate the leaf area of specie. One thousand healthy and expanded leaves of five castor bean cultivars (New Zealand Purple, Sipeal, Carmencita, Amarelo de Irecê, and IAC-80) were collected, and 200 leaves were collected from each. The maximum length, maximum width, and leaf area were calculated for each leaf. The product between length and width (LW) were calculated. We performed tests with different linear and non-linear regression models between leaf area and linear leaf dimensions of each cultivar. The models used were linear, linear without intercept, and power. The criteria for choosing the best models to estimate the leaf area of castor beans were a higher coefficient of determination, more elevated Pearson’s linear correlation coefficient, lower Akaike information criterion, higher Willmott agreement index, and smallest root mean square error. The equations that presented the best criteria for estimating the leaf area of castor bean cultivars were those that used the product between length and width, compared to equations that used only one leaf dimension. The model ŷ = 0.439 × LW can be used to accurately and quickly estimate the castor bean leaf area through linear measurements of the leaves, using the product between length and width (LW), regardless of the cultivar chosen. ABSTRACT nondestructive non destructive lowcost low cost applications i (i ii (ii specie New Purple Sipeal Carmencita Irecê IAC80 IAC 80 IAC-80 20 (LW nonlinear intercept power determination Pearsons Pearson s criterion index error dimension 0439 0 439 0.43 LW, , chosen IAC8 8 IAC-8 2 043 43 0.4 IAC- 04 4 0.

RESUMO A aplicação de esgoto sanitário utilizando o gotejamento subsuperficial contribui para mitigar os problemas atuais de disponibilidade de água e produção de alimento. Objetivou-se avaliar o feijão-caupi recebendo esgoto sanitário por gotejadores operando com diferentes vazões e profundidades. Os gotejadores operaram com as vazões de 1,6 e 3,8 L h-1 e foram instalados nas profundidades de 0, 5, 10, 15, 20, 25 e 30 cm. O feijão-caupi foi cultivado em vasos de 65 L preenchidos com solo argiloso em casa de vegetação. Utilizou-se esgoto sanitário sintético e a quantidade aplicada nos vasos foi baseada no elemento limitante, que no caso foi o nitrogênio, para o cultivo do feijão-caupi. O manejo da irrigação foi realizado com sondas de TDR. Avaliou-se a germinação e as respostas fisiológicas e morfologia das raízes do feijão-caupi. A ascensão capilar, quando a água foi aplicada em profundidade, não foi suficiente para umedecer de maneira uniforme a superfície do solo. As variáveis de germinação apresentaram um decréscimo em função do aumento das profundidades de instalação dos gotejadores. A distribuição da água com o aumento da profundidade dos emissores foi responsável pelos prejuízos nas respostas fisiológicas e morfológicas das raízes feijão-caupi. As vazões dos gotejadores não afetaram a germinação do feijão-caupi. Utilizar o sistema de irrigação por gotejamento subsuperficial não foi apropriado para o feijão-caupi nas condições deste estudo. alimento Objetivouse Objetivou se feijãocaupi feijão caupi 16 1 6 1, 38 3 8 3, h1 h h- 0 5 10 15 20 2 cm vegetação Utilizouse Utilizou limitante nitrogênio feijãocaupi. caupi. TDR Avaliouse Avaliou capilar estudo

ABSTRACT The application of sanitary sewage using subsurface drip irrigation contributes to mitigating the current problems of water availability and food production. The aim in this study was to evaluate cowpea receiving sanitary sewage through drippers operating at different flow rates and depths. The drippers operated at flow rates of 1.6 and 3.8 L h-1 and were installed at depths of 0, 5, 10, 15, 20, 25, and 30 cm. Cowpea was grown in 65 L pots filled with sandy clay soil in a greenhouse. Synthetic sanitary sewage was used and the amount applied to the pots was based on the limiting element, which in this case was nitrogen, for growing cowpea. Irrigation was managed using TDR probes. Germination and the physiological responses and morphology of cowpea roots were assessed. Capillary rise, when water was applied in subsurface, was not sufficient to evenly moisten the soil surface. The germination variables decreased as a result of the increase in drip installation depths. The distribution of water as the depth of the emitters increased was responsible for the damage to the physiological and morphological responses of cowpea roots. The flow rates of the drippers did not affect the germination of cowpea. Using the subsurface drip irrigation system was not appropriate for growing cowpea under the conditions of this study. production 16 1 6 1. 38 3 8 3. h1 h h- 0 5 10 15 20 25 cm greenhouse element nitrogen probes assessed rise surface 2

Computational predictive approaches present themselves as an attractive alternative in the search for new compounds that may present toxic or growth regulatory activity in Aedes aegypti. Aspergillus species is a producer of secondary metabolites with diverse biological activities. In this study, it was possible to evaluate the pharmacokinetic and toxicological properties in silico, as well as the prediction of the insecticidal biological activities of the juvenile hormone of natural substances produced by the genus Aspergillus. Initially, 187 molecules were cataloged from various species of Aspergillus spp., and only seven molecules of indole alkaloids were found to exhibit a toxic dose 50% (TD50) after conducting toxicity predictions. The molecular dynamic simulation trajectories were utilized to study parameters such as root mean square deviation, root mean square fluctuation, radius of gyration and intermolecular hydrogen bond to understand the behavior and stability of proposed compounds in the binding pocket of the target protein. The N-β-acetyltryptamine molecule showed a binding affinity value of –8.100 ± 0.200 kcal mol-1, which classifies the compound as a potential insecticidal agent against the Aedes aegypti vector. silico Initially 18 spp spp. 50 TD50 TD (TD50 predictions deviation fluctuation protein Nβacetyltryptamine N β acetyltryptamine 8100 8 100 –8.10 0200 0 200 0.20 mol1, mol1 mol 1, 1 mol-1 vector 5 TD5 (TD5 810 10 –8.1 020 20 0.2 mol- (TD 81 –8. 02 2 0. –8 –

RESUMO Objetivo: Examinar a associação entre vitimização por bullying e comportamentos de risco à saúde em adolescentes. Métodos: Uma amostra representativa de 1.020 adolescentes participou do estudo. As variáveis bullying, comportamentos de risco à saúde (tabaco, drogas, álcool, comportamento sedentário, uso de smartphone, nível de atividade física, sono) e situação econômica foram avaliadas por meio de questionários autorreportados. Razões de chance com intervalos de confiança de 95% (IC95%) foram obtidas por meio de regressão logística binária e regressão logística ordinal, bruta e ajustada (p<0,05). Resultados: As vítimas de bullying apresentaram maior probabilidade de fumar (OR 1,75; IC95% 1,28–2,40), consumir álcool (OR 1,43; IC95% 1,05–1,94), ter pior qualidade de sono (OR 1,94; IC95% 1,28–2,91) e apresentar mais comportamento sedentário (OR 1,43; IC95% 1,08–1,89) do que aqueles que não sofreram bullying. No entanto, as vítimas eram mais propensas a ter níveis elevados de atividade física do que os seus pares não vítimas de bullying (OR 1,66; IC95% 1,22–2,27). Conclusões: A vitimização por bullying esteve associada ao aumento da predisposição para a adoção de comportamentos de risco à saúde. Curiosamente, as vítimas também eram mais propensas a participar de atividades físicas. Objetivo Métodos 1020 1 020 1.02 estudo tabaco, tabaco (tabaco drogas smartphone autorreportados 95 IC95 IC (IC95% ordinal p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Resultados OR 1,75 175 75 1,28–2,40, 128240 1,28–2,40 , 28 2 40 1,28–2,40) 1,43 143 43 1,05–1,94, 105194 1,05–1,94 94 1,05–1,94) 1,94 194 1,28–2,91 128291 91 1,08–1,89 108189 08 89 entanto 1,66 166 66 1,22–2,27. 122227 1,22–2,27 22 27 1,22–2,27) Conclusões Curiosamente físicas 102 02 1.0 9 IC9 (IC95 p00 p<0,0 (p<0,05 1,7 17 7 12824 1,28–2,4 4 1,4 14 10519 1,05–1,9 1,9 19 1,28–2,9 12829 1,08–1,8 10818 8 1,6 16 6 12222 1,22–2,2 10 1. (IC9 p0 p<0, (p<0,0 1, 1282 1,28–2, 1051 1,05–1, 1,08–1, 1081 1222 1,22–2, (IC p<0 (p<0, 128 1,28–2 105 1,05–1 1,08–1 108 122 1,22–2 p< (p<0 12 1,28– 1,05– 1,08– 1,22– (p< 1,28 1,05 1,08 1,22 (p 1,2 1,0

ABSTRACT Objective: The aim of this study was to examine the association between bullying victimization and health risk behaviors in adolescents. Methods: A representative sample of 1020 adolescents participated in the study. The variables such as bullying, health risk behaviors (tobacco, drugs, alcohol, sedentary behavior, smartphone use, level of physical activity, and sleep), and economic status were assessed using self-reported questionnaires. Odds ratios with 95% confidence intervals (95%CI) were obtained using binary logistic regression and ordinal, gross, and adjusted logistic regression (p<0.05). Results: Victims of bullying were more likely to smoke (OR 1.75; 95%CI 1.28–2.40), consume alcohol (OR1.43; 95%CI 1.05–1.94), have worse sleep quality (OR 1.94; 95%CI 1.28–2.91), and more sedentary behavior (OR 1.43; 95%CI 1.08–1.89) than those who were not bullied. However, victims were more likely to have high levels of physical activity than their non-bullied peers (OR 1.66; 95%CI 1.22–2.27). Conclusions: Bullying victimization was associated with an increased predisposition for the adoption of health risk behaviors. Interestingly, victims were also more prone to participate in physical activity. Objective Methods 102 tobacco, tobacco (tobacco drugs use sleep, , sleep) selfreported self reported questionnaires 95 95CI CI (95%CI ordinal gross p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Results OR 1.75 175 1 75 1.28–2.40, 128240 1.28–2.40 28 2 40 1.28–2.40) OR1.43 OR143 OR1 43 (OR1.43 1.05–1.94, 105194 1.05–1.94 94 1.05–1.94) 1.94 194 1.28–2.91, 128291 1.28–2.91 91 1.28–2.91) 1.43 143 1.08–1.89 108189 08 89 bullied However nonbullied non 1.66 166 66 1.22–2.27. 122227 1.22–2.27 22 27 1.22–2.27) Conclusions Interestingly 10 9 p00 p<0.0 (p<0.05 1.7 17 7 12824 1.28–2.4 4 OR1.4 OR14 (OR1.4 10519 1.05–1.9 1.9 19 12829 1.28–2.9 1.4 14 1.08–1.8 10818 8 1.6 16 6 12222 1.22–2.2 p0 p<0. (p<0.0 1. 1282 1.28–2. OR1. (OR1. 1051 1.05–1. 1.08–1. 1081 1222 1.22–2. p<0 (p<0. 128 1.28–2 (OR1 105 1.05–1 1.08–1 108 122 1.22–2 p< (p<0 12 1.28– 1.05– 1.08– 1.22– (p< 1.28 1.05 1.08 1.22 (p 1.2 1.0

RESUMO Objetivo: descrever a condição miofuncional orofacial global de pacientes com traumatismos faciais e analisar aspectos posturais e de mobilidade relacionados à função deglutição em diferentes etapas de recuperação. Métodos: estudo analítico e transversal. 36 participantes, idade entre 19 e 67 anos. Realizada em cinco etapas (D1, D2, D3, D4 e D5): oitavo ao sexagésimo dia após trauma. Utilizou-se o Protocolo de Avaliação Miofuncional Orofacial com Escores (AMIOFE) adaptado. Foi realizada análise estatística descritiva e inferencial, utilizando os testes t-Student pareado ou teste Wilcoxon pareado e o teste de Friedman na comparação entre as cinco avaliações. A margem de erro utilizada na decisão dos testes estatísticos foi de 5%. Resultados: nos movimentos labiais a maioria (69,4%) tinha inabilidade severa. Nos movimentos da língua, as duas categorias relacionadas, falta de precisão e inabilidade severa, apresentaram percentuais de 52,8% e 41,7%, respectivamente. Na movimentação da mandíbula, a maioria (83,3%) apresentava inabilidade severa. No escore AMIOFE, a mediana foi menos elevada em D1 (29,00), seguida por D2 (33,00), mais elevada em D5 (46,00) e variou de 39,50 a 41,00 nas outras duas avaliações com diferenças significativas entre: D1 diferente de D3, D4 e D5 e D2 diferente de D5. Conclusão: houve evolução positiva espontânea da condição miofuncional orofacial ao longo das avaliações. Contudo, é necessária atenção dos profissionais envolvidos. Objetivo recuperação Métodos transversal 3 participantes 1 6 anos D1, D (D1 D3 D5) trauma Utilizouse Utilizou se AMIOFE (AMIOFE adaptado inferencial tStudent t Student 5 5% Resultados 69,4% 694 69 4 (69,4% severa língua relacionadas 528 52 8 52,8 417 41 7 41,7% respectivamente mandíbula 83,3% 833 83 (83,3% 29,00, 2900 29,00 , 29 00 (29,00) 33,00, 3300 33,00 33 (33,00) 46,00 4600 46 (46,00 3950 39 50 39,5 4100 41,0 Conclusão Contudo envolvidos (D 69,4 (69,4 52, 41,7 83,3 (83,3 290 29,0 2 0 (29,00 330 33,0 (33,00 46,0 460 (46,0 395 39, 410 41, 69, (69, 83, (83, 29, (29,0 33, (33,0 46, (46, (69 (83 (29, (33, (46 (6 (8 (29 (33 (4 ( (2 (3

ABSTRACT Purpose: to describe the global orofacial myofunctional condition of patients presented with facial trauma and analyze postural and mobility aspects related to swallowing function at different stages of recovery. Methods: an analytical and cross-sectional study with 36 participants, aged 19 to 67 years, conducted in five stages (D1, D2, D3, D4, and D5), on the 8th to 60th day after trauma, using the adapted Orofacial Myofunctional Evaluation Protocol with Scores (OMES). Descriptive and inferential statistical analysis was performed using the paired Student's t-test or paired Wilcoxon test, and the Friedman test which compared the five evaluations. A 5% margin of error was used in the decision of the statistical tests. Results: in lip movements, the majority (69.4%) had severe inability. In tongue movements, the two related categories (imprecise and severe inability) had percentages of 52.8% and 41.7%, respectively. In jaw movements, the majority (83.3%) had severe inability. The median OMES score was lowest in D1 (29.00), followed by D2 (33.00), highest in D5 (46.00), and ranged from 39.50 to 41.00 in the other two evaluations, with significant differences between D1 and D3, D4 and D5, and D2 and D5. Conclusion: the orofacial myofunctional condition progressed, spontaneously and positively, throughout the evaluations. However, attention is needed from the professionals involved. Purpose recovery Methods crosssectional cross sectional 3 participants 1 6 years D1, D (D1 D3 , D5) th OMES. . (OMES) Students Student s ttest t evaluations 5 tests Results movements 69.4% 694 69 4 (69.4% inability imprecise 528 52 8 52.8 417 41 7 41.7% respectively 83.3% 833 83 (83.3% 29.00, 2900 29.00 29 00 (29.00) 33.00, 3300 33.00 33 (33.00) 46.00, 4600 46.00 46 (46.00) 3950 39 50 39.5 4100 41.0 Conclusion progressed positively However involved (D (OMES 69.4 (69.4 52. 41.7 83.3 (83.3 290 29.0 2 0 (29.00 330 33.0 (33.00 460 46.0 (46.00 395 39. 410 41. 69. (69. 83. (83. 29. (29.0 33. (33.0 46. (46.0 (69 (83 (29. (33. (46. (6 (8 (29 (33 (46 ( (2 (3 (4

ABSTRACT Purpose: This study aimed to evaluate the total macular thickness as well as the thickness of the inner and outer retinal layers in patients with Parkinson’s disease. It also aimed to verify the correlation of these parameters with motor symptoms and cognitive function. Methods: A total of 46 eyes of 23 patients with Parkinson’s disease and 40 eyes of 20 healthy controls were included in the study. The patients’ cognitive, functional, and nonmotor symptoms were evaluated using the Katz Index of Independence and Pfeffer’s Activities of Daily Living, Mini-Mental State Examination, Frontal Assessment Battery, Schwab and England Staging Scales, and Movement Disorders Society Nonmotor Symptoms Scale. The macular thickness measurements obtained via total, inner, and outer optical coherence tomography were recorded. Furthermore, the correlation of the parameters of optical coherence tomography with cognitive, functional, and nonmotor symptoms was assessed. Results: The scores of the Katz Index of Independence and Pfeffer’s Activities of Daily Living as well as the Movement Disorders Society Nonmotor Symptoms Scale were significantly lower in patients with Parkinson’s disease than in healthy controls. Moreover, the former had greater total macular thickness. The temporal and inferior outer sectors were significantly greater for the ganglion cell complex thickness in patients. A significant correlation was observed between the total macular thickness and the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale, Parte III (MDS-UPDRS-III) values. Contrarily, there was a negative correlation between the outer macular thickness and the MDS-UPDRS-III values. Meanwhile, the total macular thickness and ganglion cell complex thickness were significantly correlated with the scores of the Mini-Mental State Examination, Schwab and England Staging Scale, Frontal Assessment Battery, and Katz Index of Independence and Pfeffer’s Activities of Daily Living. In addition, the Schwab and England scale was correlated with the outer macular thickness. Conclusion: The total and inner macular thicknesses at the temporal and inferior outer sectors were greater in patients with Parkinson’s disease than in the control group. These findings indicate that macular thickness may be greater in those with Parkinson’s disease, particularly when associated with mild motor symptoms. In addition, the parameters of the total, inner, and outer optical coherence tomography were significantly associated with motor and nonmotor symptoms as well as cognitive function impairment. Purpose Parkinsons Parkinson s Methods 4 2 functional Pfeffers Pfeffer MiniMental Mini Mental Examination Battery Scales recorded Furthermore assessed Results Moreover SocietyUnified Unified MDSUPDRSIII MDS UPDRS (MDS-UPDRS-III values Contrarily Meanwhile addition Conclusion group impairment

This study evaluated the potential of naphthoxazoles derived from lapachol as fluorescent deoxyribonucleic acid (DNA) probes. We synthesized three 2-substituted naphthoxazoles: one with a phenyl group (LOX1), and two with 2-hydroxyphenyl (LOX2) and 4-fluorophenyl (LOX3) groups, respectively. The compounds were synthesized using the Debus-Radziszewski reaction between the lapachol and aldehydes. The quantum yield (Φf) was determined using the classical relative method with 4’,6-diamidino-2-phenylindole (DAPI) as the standard, and the fluorescence lifetime (τf) was measured with a lifetime fluorescence spectrometer. The naphthoxazoles exhibited low fluorescence emission and consequently low values of Φf in their free form, demonstrating behavior similar to that of DAPI. These compounds displayed notably large Stokes shifts (approximately 340 nm) and the τf in the nanosecond range. DNA binding studies were conducted by monitoring changes in the absorption properties of naphthoxazoles in the absence and presence of calf thymus DNA at different concentrations. The results indicated that naphthoxazoles interacted with DNA through groove binding. LOX2 exhibited a binding constant (Kb) of 2.70 × 104 M-1, indicating strong binding to the biomolecule. These findings underscore the potential of LOX1, LOX2, and LOX3 as candidates for use as fluorescent DNA probes. (DNA probes 2substituted substituted 2 LOX1 LOX , (LOX1) 2hydroxyphenyl hydroxyphenyl (LOX2 4fluorophenyl fluorophenyl 4 (LOX3 groups respectively DebusRadziszewski Debus Radziszewski aldehydes (Φf 4,6diamidino2phenylindole 46diamidino2phenylindole diamidinophenylindole ,6 diamidino phenylindole 6 DAPI (DAPI standard (τf spectrometer form approximately 34 nm range concentrations Kb (Kb 270 70 2.7 10 M1, M1 M 1, 1 M-1 biomolecule (LOX1 (LOX 6diamidino2phenylindole 3 27 7 2. M-

In this work we explore some theoretical and practical aspects of one-pot synthesis. The focal point of the study is the preparation of the thiazole heterocycle, with an emphasis on theoretical aspects of the organic and medicinal chemistry of this important privileged structure. The entire set of experimental procedures and characterization steps explored in this work has the potential to assist in the training and/or technical improvement of undergraduate students, and contribute to the teaching of chemistry in Brazilian higher education. It is worth emphasizing these aspects because the experiments shown in the proposed practices involve simple, rapid, low-risk, and low-cost procedures, making it perfectly feasible to reproduce them in undergraduate classes, even in laboratories with limited material resources. onepot one pot synthesis heterocycle structure andor or students education simple rapid lowrisk, lowrisk low risk, risk low-risk lowcost cost classes resources