Abstract Objective: Correlate serum magnesium (Mg) and Calcium (Ca) levels with body composition and metabolic parameters in women with fibromyalgia (FM). Patients and methods: Cross-sectional study compared with a control group paired by age and body mass index (BMI) of adult women diagnosed with fibromyalgia. All participants went through assessment of their body composition through dual-energy X-ray absorptiometry (DXA) and had blood samples collected for dosing of Mg, Ca, C-reactive Protein (CRP), lipidogram and glycemia. Results: 53 women with FM (average age 48.1 ±8.2 years, average BMI 26.6 ±4.5 kg/m2) and 50 control women (average age 47.1 ±9.9 years, average BMI 25.6 ± 3.6 kg/m2) participated in the study. Serum levels turned out to have inverse correlation with CRP in the FM group (r = −0.29, p = 0.03) and with BMI and glycemia in the control group (r = 0.31; p = 0.02 and r = 0.48; p = 0.0004 respectively). Serum levels of calcium correlated with triglycerides (r = 0.29; p = 0.03) in the FM group and with glycemia in the control group (r = 0.64; p = 0.0001). Conclusions: In patients with FM, magnesemia turned out to have inverse correlation with CRP and calcemia had positive association with triglycerides.

Abstract Objective: Determine food intake and levels of serum magnesium (Mg) and calcium (Ca) and correlate these minerals with pain, quality of life and depression risk in women with and without fibromyalgia (FM). Patients and methods: Fifty-three women diagnosed with FM and 50 healthy women participated in the study, where all of them had equivalent age and body mass index (BMI). All women underwent anthropometric assessment, physical exams of pain perception threshold and tender point (TP) count, blood sample collection, and filling out of FM impact questionnaire (FIQ), Patient Health Questionnaire-9 (PHQ-9), and 3-day dietary record (DR). Results: Dietary intake of Mg and Ca was substantially lower by women with FM. There were no differences in levels of serum Mg and Ca in the groups under analysis. For the FM group, dietary intake of Mg and Ca had inverse correlation with TP and direct relation with the pain threshold. Conclusions: Although women with FM had lower dietary intake of Mg and Ca, serum levels for these nutrients were not different between the groups. Low dietary intake of minerals correlated with worsened pain threshold parameters.

ABSTRACT Objectives The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat). Subjects and methods The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass. Results Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups. Conclusions No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/obesity.

RESUMO Comparar a ingestão alimentar de mulheres com e sem fibromialgia e verificar se a ingestão alimentar das pacientes com fibromialgia interfere na sensação de dor e qualidade de vida.Participaram do estudo mulheres com fibromialgia (FM) atendidas no Ambulatório de Fibromialgia do Hospital de Clínicas/UFPR e para o grupo controle (CT) foram convidadas mulheres saudáveis. A coleta de dados foi feita de março a outubro de 2012. Para a avaliação do consumo alimentar foi usado o Registro Alimentar e os itens analisados foram: calorias totais, carboidratos, proteínas, lipídeos, vitaminas (A, C, B12, D e E) e minerais (folato, selênio, zinco, cálcio, ferro e magnésio). O software usado foi o Avanutri Online®. Para avaliação da qualidade de vida foi usado o Questionário de Impacto da Fibromialgia (FIQ) e limiar doloroso.Foram avaliadas 43 pacientes com FM e 44 mulheres saudáveis. O grupo CT apresentou consumo médio de nutrientes superior ao grupo FM, com exceção para o ferro. Entretanto, somente a ingestão calórica, carboidratos, proteínas e lipídeos em gramas, porcentagem de lipídios, vitamina A, E, B12, folato, selênio e cálcio foram estatisticamente significativas. No grupo FM houve correlação negativa entre vitamina E e FIQ e correlação positiva entre porcentagem de proteína e limiar doloroso.As mulheres com FM apresentaram ingestão qualitativamente e quantitativamente inferior ao grupo CT. Somente a vitamina E apresentou correlação com a qualidade de vida e a porcentagem de proteína na dieta com a sensação de dor.

ABSTRACT Objective: To compare the food intake of women with and without fibromyalgia and verify if the food intake of patients with fibromyalgia interferes with the pain and quality of life. Methods: Study participants were women with fibromyalgia (FM) seen in Fibromyalgia Outpatient Clinic, Hospital das Clínicas/UFPR and a control group (CT) with healthy women. Data collection was conducted from March to October 2012. For the assessment of food intake we used the Food Registration and analyzed items were: total calories, carbohydrates, proteins, lipids, vitamins (A, C, B12, D and E) and minerals (folate, selenium, zinc, iron, calcium and magnesium). The software used was Avanutri Online®. To evaluate the quality of life, the Fibromyalgia Impact Questionnaire (FIQ) and pain threshold were used. Results: 43 patients with FM and 44 healthy women were evaluated. CT group showed a mean consumption of nutrients greater than FM group except for iron. However, only caloric intake, carbohydrates, proteins and lipids in grams and percentage of lipids, vitamin A, E, B12, folate, selenium and calcium were statistically significant. In FM group there was a negative correlation between vitamin E and FIQ and a positive correlation between percentage of protein and pain threshold. Conclusion: Women with FM showed a lower qualitatively and quantitatively intake in comparison with CT group. Only vitamin E correlated with quality of life and percentage of protein in the diet with sensation of pain.

Objetivos: Avaliar a composição corporal de mulheres com fibromialgia (FM) em relação ao valor de referência para mulheres saudáveis. Pacientes e Métodos: Estudo transversal observacional, composto por 52 mulheres diagnosticadas com fibromialgia conforme os critérios do American College of Rheumatology (ACR, 1990), selecionadas no Ambulatório de Fibromialgia do Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR). As pacientes voluntárias foram divididas em dois grupos, 28 pacientes com Índice de Massa Corporal (IMC) igual ou superior (≥) a 25 kg/m2, e 24 pacientes com IMC igual ou inferior (≤) a 24,99 kg/m2 e submetidas ao exame físico para a contagem dos tender points (TP), além de preencherem o questionário de impacto da fibromialgia (FIQ). A avaliação da composição corporal foi realizada por meio da Absorciometria Radiológica de Dupla Energia (DXA). Os valores do percentual de massa gorda (% de MG), encontrados nos dois grupos, foram comparados ao percentual médio de MG por idade e sexo, descrito por Heward (2004). Resultados: A idade média dos grupos pesquisados foi de 47,8 ± 8,6 anos, o score do FIQ foi de 70,5 ± 18,6 e TP 16,2 ± 2,0. O IMC médio foi de 26,4 ± 4,1 kg/m2, e a quantidade de MG foi de 25,2 ± 7,8 kg ou 39,5% ± 6,8%, e de massa magra (MM) foi de 37,2 ± 3,7 kg ou 60,4% ± 7,3%. No grupo com IMC ≤ 25 kg/m2 o percentual de MG foi de 33,8% (21,5 - 42,4), e no grupo com IMC ≥ 25 kg/m2 o percentual de MG foi de 44,4% (37,6 - 56,2). Conclusão: Tanto mulheres com FM eutróficas quanto as com sobrepeso e obesas apresentaram percentual de MG acima dos valores de referência de mulheres saudáveis.

Objectives: To assess body composition in women with fibromyalgia (FM) comparing to the reference value for healthy women. Patients and Methods: Cross-sectional observational analytical study, with 52 women selected with Fibromyalgia, according American College of Rheumatology (ACR, 1990) criteria. The patients were selected in Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR) and divided into two groups, 28 patients with a BMI (Body Mass Index) equal or higher (≥) than 25 kg/m2 and 24 patients with BMI less or equal (≤) 24.99 kg/m2, subjected to physical examination for the count of tender points (TP) and completing the fibromyalgia impact questionnaire (FIQ). The assessment of body composition was performed by the Dual-Energy X-Ray Absorptiometry (DXA). The values of the fat mass percentage (MG %) found in the two groups were compared to the average percentage of MG by age and sex, described by Heward (2004). Results: The mean age of the study groups was 47.8 ± 8.6 years, the FIQ score was 70.5 ± 18.6 and TP 16.2 ± 2.0. The mean BMI was 26.4 ± 4.1 kg/m2, and the amount of MG was 25.2 ± 7.8 kg and 39.5 ± 6.8%, and lean mass (LM) was 37 2 ± 3.7 kg and 60.4 ± 7.3%. In the group with BMI ≤ 25 kg/m2, the MG % was 33.8% (21.5 - 42.4) and in the group with BMI ≥ 25 kg/m2 of the MG was 44.4% (37.6 - 56.2). Conclusion: Both groups women with FM eutrophic as the overweight and obese group, presented higher reference MG% levels comparing with the standard levels for healthy women.