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Mast cells in oral lichen planus and oral lichenoid lesions related to dental amalgam contact
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NORONHA, Mariana Saturnino de

; SOUTO, Giovanna Ribeiro

; FELIX, Fernanda Aragão

; ABREU, Lucas Guimarães

; AGUIAR, Maria Cássia Ferreira

; MENDONÇA, Elismauro Francisco

; MESQUITA, Ricardo Alves

Brazilian Oral Research

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2024, Volume 38 elocation e005

Abstract: En | Text: En | PDF: En

Abstract The aim of this study was to analyze the expression of mast cell markers toluidine blue, c-kit, and tryptase and presence of mononuclear inflammatory cells in oral lichen planus (OLP) and oral lichenoid lesions related to dental amalgam. Nineteen specimens of OLP, OLLC, and healthy oral mucosa were selected. Mononuclear inflammatory cells were analyzed. Histochemical and immunohistochemical analyses were performed using toluidine blue, anti-c-kit and anti-tryptase reagents, and the results were quantified in areas A and B of connective tissue. Mast cells of all OLP and OLLC samples were positive for toluidine blue, c-kit, and tryptase. The density of toluidine blue+, c-kit+ and tryptase+ mast cells was higher in tissue with OLP and OLLC compared with healthy controls (p < 0.05). No difference was noted in mast cells density between OLP and OLLC (p > 0.05). The density of tryptase+ mast cells was higher in the subepithelial region (area A) than the region below it (Area B) in OLLC (p = 0.047). The mononuclear inflammatory cell density was higher in OLLC compared to OLP, but without statistical significance (p > 0.05). A positive statistical correlation was found between mononuclear immune cells and density of c-kit+ and tryptase+ mast cells in OLP (r = 0.943 and r = 0.886, respectively). Our data demonstrate that the etiopathogenesis process of OLP and OLLC modulates the expansion and degranulation of mast cells; mast cells density, however, was similar between OLP and OLLC. The distribution of mast cells appears to vary along the lamina propria. blue ckit, ckit c kit, kit c-kit (OLP amalgam selected analyzed antickit anti antitryptase reagents blue+ ckit+ kit+ p 0.05. 005 0.05 . 0 05 0.05) area Area 0.047. 0047 0.047 047 0.047) 0943 943 0.94 0886 886 0.886 respectively. respectively respectively) however propria 00 0.0 004 0.04 04 094 94 0.9 088 88 0.88 0. 09 9 08 8 0.8

https://doi.org/10.1590/1807-3107bor-2024.vol38.0005

Methodological Quality of Systematic Reviews Addressing Orthodontic Interventions: Methodological Study Interventions
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Notaro, Sarah Queiroz

; Hermont, Ana Paula

; Cruz, Poliana Valdelice

; Maia, Raiane Machado

; Avila, Walesca Melo

; Pericic, Tina Poklepovic

; Abreu, Lucas Guimarães

; Jiao, Ruimin

; Martins-Pfeifer, Carolina Castro

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2024, Volume 24 elocation e230074

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To assess the methodological quality and characteristics of systematic reviews (SRs) of interventional studies in orthodontics and assess how the certainty of the evidence is reported using the GRADE approach. Material and Methods: Six electronic databases were searched, followed by a hand search of the reference lists of eligible studies (PROSPERO #CRD42020180852). The required study design was randomized and nonrandomized studies of interventions published between January 2019 and May 2020. The Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) tool was used for the quality appraisal of the included SRs. Paired reviewers independently screened the studies, extracted data, and appraised the methodological quality. Results: The study included 46 SRs; 19.5% had moderate to high methodological quality, and the remaining had low to critically low methodological quality. Fifty-four percent of the reviews assessed the certainty of evidence using the GRADE approach, and 34.8% followed all GRADE criteria. Conclusion: Most reviews had a good judgment of the AMSTAR2 items, although some critical items contributed to decreased overall quality. Half of the reviews used the GRADE approach to assess the certainty of the evidence, and this approach should be included in future systematic reviews of interventions. Objective SRs (SRs Methods searched PROSPERO #CRD42020180852. CRD42020180852 CRD #CRD42020180852 . #CRD42020180852) 201 2020 AMSTAR 2 data Results 4 195 19 5 19.5 Fiftyfour Fifty four 348 34 8 34.8 criteria Conclusion CRD4202018085 #CRD4202018085 20 202 1 19. 3 34. CRD420201808 #CRD420201808 CRD42020180 #CRD42020180 CRD4202018 #CRD4202018 CRD420201 #CRD420201 CRD42020 #CRD42020 CRD4202 #CRD4202 CRD420 #CRD420 CRD42 #CRD42 CRD4 #CRD4 #CRD

https://doi.org/10.1590/pboci.2024.040

Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and meta-analysis Overweightobesity Overweight obesity adolescents metaanalysis meta analysis
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PIZZI, Julia Faria

; CARRADA, Camila Faria

; ZEFERINO, Maria Vitória de Sá

; DORIGUÊTTO, Paulo Victor Teixeira

; ABREU, Lucas Guimarães

; SCALIONI, Flávia Almeida Ribeiro

; DEVITO, Karina Lopes

; RIBEIRO, Rosangela Almeida

Brazilian Oral Research

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2024, Volume 38 elocation e015

Abstract: En | Text: En | PDF: En

Abstract This review aimed to assess the association between overweight/obesity and dental caries in Brazilian children/adolescents. Searches were performed in the Web of Science, Scopus, Cochrane, PubMed, Embase and SciELO, Lilacs and Open Grey literature databases up to June 2022. The Joanna Briggs Institute checklist for analytical cross-sectional studies, the checklist for cohort studies, and the checklist for case-control studies were used. A total of 41 publications were included, and 15 meta-analyses were performed. The authors analyzed the differences in weighted mean difference (MD) and odds ratios (OR), and their corresponding confidence intervals (CI) (95%) for dental caries among eutrophic and obese and/or overweight children/adolescents. Meta-analyses showed that there was no association between overweight and/or obesity and dental caries in Brazilian children/adolescents for most anthropometric reference curves using BMI (Body Mass Index). A greater experience of dental caries was associated with well-nourished adolescents in permanent dentition, compared with obese individuals in the same dentition, as classified by the CDC 2000 curve (OR = 2.53, 95% CI;1.49–4.29; p = 0.0006; I2 = 0%) in dichotomous outcome studies, and (MD = 0.61, 95%CI: 0.08–1.15; p = 0.02; I2 = 0%) in continuous studies. The strength of the evidence of the results was classified as very low, low or moderate. It was concluded that there is no association between overweight and/or obesity and dental caries in Brazilian children/adolescents for most anthropometric reference curves using BMI. A greater experience of dental caries was associated with well-nourished adolescents in permanent dentition, compared with obese individuals in the same dentition, as classified by the CDC 2000 curve. overweightobesity childrenadolescents children Science Scopus Cochrane PubMed SciELO 2022 crosssectional cross sectional casecontrol case control used 4 included 1 metaanalyses meta analyses MD OR, OR , (OR) CI (CI 95 (95% andor Metaanalyses Meta Body Index. Index . Index) wellnourished well nourished dentition 200 253 2 53 2.53 CI1.49–4.29 CI149429 1.49–4.29 49 29 CI;1.49–4.29 0.0006 00006 0 0006 I 0% 061 61 0.61 95%CI 95CI 0.08–1.15 008115 08 0.02 002 02 moderate 202 9 (95 20 25 5 2.5 CI1 CI1.49–4.2 CI14942 149429 1.49–4.2 CI;1.49–4.2 0.000 0000 000 06 6 0.6 0.08–1.1 00811 0.0 00 (9 2. CI1.49–4. CI1494 14942 1.49–4. CI;1.49–4. 0.00 0. 0.08–1. 0081 ( CI1.49–4 CI149 1494 1.49–4 CI;1.49–4 0.08–1 008 CI1.49– CI14 149 1.49– CI;1.49– 0.08– CI1.49 14 1.49 CI;1.49 0.08 CI1.4 1.4 CI;1.4 CI1. 1. CI;1. CI;1 CI;

https://doi.org/10.1590/1807-3107bor-2024.vol38.0015

Fatores associados ao escore de ansiedade de mães surdas e ouvintes
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Nogueira, Raquel Fabiane

; Paiva, Saul Martins

; Carcavalli, Larissa

; Prado, Ivana Meyer

; Castro-Braga, Mirian

; Abreu, Lucas Guimarães

; Serra-Negra, Júnia Maria

CoDAS

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2024, Volume 36 N. 5 elocation e20230239

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Associar a ansiedade materna aos fatores sociodemográficos, pratica de aleitamento, hábitos bucais e ingresso da criança em creche entre mulheres surdas e ouvintes. Método Participaram deste estudo transversal retrospectivo comparativo, 116 mães (29 surdas e 87 ouvintes) de crianças na faixa etária entre dois e cinco anos. As mães surdas pertenciam a um centro de referência da cidade e as mães ouvintes foram contatadas em creches públicas, onde seus filhos estavam matriculados. As mães foram submetidas a entrevista sobre fatores socioeconômicos e relacionados ao desenvolvimento dos filhos, além de realizarem o preenchimento do Inventário Brasileiro de Ansiedade de Beck, nas versões para surdos e ouvintes, que foram instrumentos usados para avaliar a ansiedade. O teste de normalidade de Kolmogorov-Smirnov, os testes de Kruskal Wallis, Mann-Whitney e Regressão de Poisson foram utilizados para análises estatísticas (p <0,05). Resultados Mães surdas apresentaram escore de ansiedade uma vez e meia maior que mães ouvintes. Além disso, mães de crianças com hábito de sucção de dedo apresentaram maior escore de ansiedade e mães cujos filhos começaram a frequentar a creche ainda bebês apresentaram menor escore de ansiedade, quando comparados a crianças sem o hábito e que não frequentavam a creche. Conclusão Mães surdas apresentaram maior ansiedade quando comparadas às ouvintes. Comportamento dos filhos com hábitos de sucção de dedo e o ingresso em creches no primeiro ano de vida influenciaram a ansiedade materna. sociodemográficos aleitamento comparativo 11 29 (2 8 anos públicas matriculados Beck KolmogorovSmirnov, KolmogorovSmirnov Kolmogorov Smirnov, Smirnov Kolmogorov-Smirnov Wallis MannWhitney Mann Whitney p &lt0,05. lt005 lt &lt 0,05 . 0 05 <0,05) disso 1 2 ( lt0 &lt0,05 lt00 005 0,0 <0,05 &lt0,0 00 0, <0,0 &lt0, <0, &lt0 <0 <

ABSTRACT Purpose To associate maternal anxiety with sociodemographic factors, breastfeeding practices, oral habits, and the child’s entry into daycare among deaf and hearing (non-deaf) mothers. Methods This retrospective comparative cross-sectional study included 116 mothers (29 deaf and 87 hearing) of children aged between two and five years. Deaf mothers belonged to a reference center in the city, while hearing mothers were contacted in public daycares where their children were enrolled. Mothers underwent interviews covering socio-economic factors and child development-related aspects. Additionally, they completed the Brazilian Beck Anxiety Inventory, adapted for both deaf and hearing individuals, serving as instruments to assess anxiety. The Kolmogorov-Smirnov normality test, Kruskal Wallis test, Mann-Whitney test, and Poisson Regression were employed for statistical analyses (p<0.05). Results Deaf mothers exhibited anxiety scores one and a half times higher than hearing mothers. Moreover, mothers of children with thumb-sucking habits showed higher anxiety scores, while mothers whose children started attending daycare as infants demonstrated lower anxiety scores compared to mothers of children without such habits and who did not attend daycare. Conclusion Deaf mothers displayed higher anxiety levels when compared to hearing mothers. Children’s behaviors, such as thumb-sucking habits, and early enrollment in daycare during the first year of life influenced maternal anxiety. practices childs s nondeaf non (non-deaf crosssectional cross sectional 11 29 (2 8 years city enrolled socioeconomic socio economic developmentrelated development related aspects Additionally Inventory individuals KolmogorovSmirnov Kolmogorov Smirnov test MannWhitney Mann Whitney p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Moreover thumbsucking thumb sucking Childrens Children behaviors 1 2 ( p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.1590/2317-1782/20242023239pt

Oral leukoplakia and erythroplakia in young patients: a southern Brazilian multicenter study patients
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SOARES, Alini Cardoso

; GOMES, Ana Paula Neutzling

; CALDERIPE, Camila Barcellos

; SALUM, Fernanda Gonçalves

; CHERUBINI, Karen

; MARTINS, Manoela Domingues

; SCHUCH, Lauren Frenzel

; KIRSCHNICK, Laura Borges

; ABREU, Lucas Guimarães

; SANTOS-SILVA, Alan Roger

; VASCONCELOS, Ana Carolina Uchoa

Brazilian Oral Research

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2024, Volume 38 elocation e069

Abstract: En | Text: En | PDF: En

Abstract The objective of the present study was to investigate the frequency of oral leukoplakia and oral erythroplakia among young patients from three Brazilian reference centers in Oral and Maxillofacial Pathology. A retrospective study was carried out from 2011 to 2021 on 861 patients diagnosed with oral leukoplakia and oral erythroplakia. Demographic and clinicopathological data were evaluated. Fisher’s exact test was used to evaluate the association among sex, age, anatomical location, and histopathological diagnosis. A total of 83 (9.64%) cases involved young patients (aged <40 years). Among these, biopsy records were included in 31 (37.34%) cases, all of which received a clinical diagnosis of oral leukoplakia. Seventeen (54.84%) patients were female, mostly in their fourth decade of life (n = 22/70.97%), and their mean age at diagnosis was 32.61(± 5.21) years. Among informed cases, seven (22.58%) patients were smokers. The lateral border of the tongue (n = 9/29.03%) was the most affected site. In 13 (41.94%) cases, oral leukoplakias showed a homogeneous appearance. The mean size of the lesions was 1.47 cm (0.2–3.0 cm) and the mean time of disease progression was 64.37 (± 65.90) months. The histopathological analysis showed that 11 cases (35.48%) exhibited some degree of epithelial dysplasia. Acanthosis and/or hyperkeratosis were observed in 20 cases (64.52%). No significant associations were observed between sex and anatomical location, age and anatomical location, nor between sex and histological diagnosis (p > 0.05). Oral leukoplakia and oral erythroplakia are uncommon diseases in young patients. In this population, oral leukoplakia shows a slight predilection for women aged between 30 and 39 years. Pathology 201 202 86 evaluated Fishers Fisher s location 8 9.64% 964 9 64 (9.64% 40 <4 years . years) these 3 37.34% 3734 37 34 (37.34% 54.84% 5484 54 84 (54.84% female n 22/70.97%, 227097 22/70.97% , 22 70 97 22/70.97%) 32.61± 3261 32.61 ± 32 61 32.61( 5.21 521 5 21 22.58% 2258 58 (22.58% smokers 9/29.03% 92903 29 03 site 1 41.94% 4194 41 94 (41.94% appearance 147 47 1.4 0.2–3.0 0230 0 2 (0.2–3. 6437 64.3 ( 65.90 6590 65 90 months 35.48% 3548 35 48 (35.48% dysplasia andor or 64.52%. 6452 64.52% 52 (64.52%) p 0.05. 005 0.05 05 0.05) population 9.64 96 6 (9.64 4 < 37.34 373 (37.34 54.84 548 (54.84 22709 22/70.97 7 326 32.6 5.2 22.58 225 (22.58 9/29.03 9290 41.94 419 (41.94 14 1. 0.2–3. 023 (0.2–3 643 64. 65.9 659 35.48 354 (35.48 645 64.52 (64.52% 00 0.0 9.6 (9.6 37.3 (37.3 54.8 (54.8 2270 22/70.9 32. 5. 22.5 (22.5 9/29.0 929 41.9 (41.9 0.2–3 02 (0.2– 65. 35.4 (35.4 64.5 (64.52 0. 9. (9. 37. (37. 54. (54. 227 22/70. 22. (22. 9/29. 92 41. (41. 0.2– (0.2 35. (35. (64.5 (9 (37 (54 22/70 (22 9/29 (41 0.2 (0. (35 (64. (3 (5 22/7 (2 9/2 (4 (0 (64 22/ 9/ (6

https://doi.org/10.1590/1807-3107bor-2024.vol38.0069

Top 100 most-cited papers on diabetes mellitus in Dentistry: a bibliometric study 10 mostcited most cited Dentistry 1
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REIS-PRADO, Alexandre Henrique dos

; PAULA, Kiani dos Santos de

; NUNES, Gabriel Pereira

; ABREU, Lucas Guimarães

; CINTRA, Luciano Tavares Angelo

; PEIXOTO, Isabella Faria da Cunha

; BENETTI, Francine

Brazilian Oral Research

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2024, Volume 38 elocation e075

Abstract: En | Text: En | PDF: En

Abstract This study assessed the features of the 100 most-cited papers on diabetes mellitus (DM) in dentistry using bibliometric measures. A search of the most cited papers on DM using journals included in the category “Dentistry, Oral Surgery and Medicine” in the Web of Science database up to January 2023 was performed. The complete bibliographic records of the selected papers were exported in plain text or Research Information Systems (RIS) file format. The following bibliometric indicators were collected: title, year, authors, number of citations, mean number of citations, institution, country, continent, study design, journal, impact factor, and keywords. Graphical bibliometric networks were created using the VOSviewer software. The number of citations for the 100 most-cited papers in DM research ranged from 111 to 566. Six papers each had more than 400 citations. Most were observational studies (n = 50) from the United States (USA) (n = 23) and were published in the Journal of Periodontology (30%; n=30). Robert Genco was the most cited author and contributed the most to the top 100 articles (3,653 citations; n = 13). The VOSviewer map of co-authorship showed the existence of clusters in research collaboration. The most prolific institutions were the Universities of Buffalo and Michigan (n = 6 each). “Diabetes mellitus” was the most frequent keyword, with 31 occurrences. In conclusion, the most cited studies that investigated the relationship between dentistry and DM were in periodontology. Observational studies, primarily from the USA, have been the most cited thus far. 10 mostcited (DM measures Dentistry, Dentistry “Dentistry Medicine 202 performed RIS (RIS format collected title year authors institution country continent design journal factor keywords software 11 566 40 50 USA (USA 23 30% 30 (30% n=30. n30 n=30 . n=30) 3,653 3653 3 653 (3,65 13. 13 13) coauthorship co authorship collaboration each. each) Diabetes keyword occurrences conclusion periodontology far 1 20 56 4 5 2 (30 n3 n=3 3,65 365 65 (3,6 (3 n= 3,6 36 (3, ( 3,

https://doi.org/10.1590/1807-3107bor-2024.vol38.0075

Fractal analysis and assessment of lacunarity in mandibular osteoradionecrosis: a cross-sectional study with control group osteoradionecrosis crosssectional cross sectional
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Barcelos, Natália Santos

; Brasileiro, Cláudia Borges

; Abreu, Lucas Guimarães

; Mendonça, Elismauro Francisco

; Sousa-Neto, Sebastião Silvério

; Sousa, Sílvia Ferreira de

; Mesquita, Ricardo Alves

; Caldeira, Patrícia Carlos

Brazilian Oral Research

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2024, Volume 38 elocation e114

Abstract: En | Text: En | PDF: En

Abstract The objective of this study was to evaluate the fractal dimension (FD) and lacunarity of the mandibular bone, comparing patients with and without osteoradionecrosis (ORN). In a cross-sectional study with a control group, 25 patients were included and divided into a case group (with ORN, n = 14) and a control group (without ORN, n = 11). A digital panoramic radiograph taken after the end of radiotherapy (RT) was evaluated for each patient. FD and lacunarity of the mandibular bone were determined using ImageJ software. Descriptive, bivariate, and ROC curve analyses were performed. Cohen's d effect sizes were calculated. Significance was established at p < 0.05. The mean FD and lacunarity values were not significantly different between the groups. The area under the curve for FD and lacunarity were 0.579 and 0.661, respectively. The cut-off point for FD was ≤1.1714 and for lacunarity, > 0.3821, correctly classifying the majority of cases and controls. Most participants in the case group (63.6%) had a FD ≤ 1.1714 and the majority of participants in the control group (63.6%) had a FD >1.1714 (p = 0.395). For lacunarity, most individuals in the case group (72.7%) had a value > 0.3821 and most participants in the control group (63.6%) had a value ≤ 0.3821 (p = 0.198). In conclusion, the FD and lacunarity values did not show statistically significant differences between patients with and without ORN. However, the moderate and large magnitude of the effects seem to indicate that the results may be clinically relevant. (FD ORN . (ORN) crosssectional cross sectional 2 14 11. 11 11) RT (RT patient software Descriptive bivariate performed Cohens Cohen s calculated 005 0 05 0.05 groups 0579 579 0.57 0661 661 0.661 respectively cutoff cut off 11714 1 1714 ≤1.171 03821 3821 controls 63.6% 636 63 6 (63.6% 1.171 >1.171 0.395. 0395 0.395 395 0.395) 72.7% 727 72 7 (72.7% 0.382 0.198. 0198 0.198 198 0.198) conclusion However relevant (ORN 00 0.0 057 57 0.5 066 66 0.66 1171 171 ≤1.17 0382 382 63.6 (63.6 1.17 >1.17 039 0.39 39 72.7 (72.7 0.38 019 0.19 19 0. 5 06 0.6 117 17 ≤1.1 038 38 63. (63. 1.1 >1.1 03 0.3 3 72. (72. 01 0.1 ≤1. (63 1. >1. (72 ≤1 (6 >1 (7 (

https://doi.org/10.1590/1807-3107bor-2024.vol38.0114

Experience with 808-nm diode laser in the treatment of 47 cases of oral vascular anomalies 808nm nm 808 4 80 8
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HEIMLICH, Fernanda Vieira

; de ARRUDA, José Alcides Almeida

; KATO, Camila de Nazaré Alves de Oliveira

; SILVA, Leni Verônica de Oliveira

; SOUZA, Leandro Napier

; FERREIRA, Marcus Vinicius Lucas

; PINHEIRO, João de Jesus Viana

; SILVA, Tarcília Aparecida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

Brazilian Oral Research

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2024, Volume 38 elocation e025

Abstract: En | Text: En | PDF: En

Abstract Treatment of oral vascular anomalies (OVA) has focused on minimally invasive techniques rather than radical surgery. We investigated the efficacy and safety of diode laser using the photocoagulation technique in the management of OVA. Forty-seven subjects with OVA were treated with forced dehydration with induced photocoagulation (FDIP) using diode laser (808 nm/4.5 W). This series consisted mostly of male (63.8%) and non-white (63.8%) patients with a mean age of 57.4 years. Varices (91.5%), venous malformations (6.4%), and hemangiomas (2.1%) with a mean size of 7.1 (±4.9) mm were the conditions treated. OVA presented as a nodular lesion (63.8%) involving mainly the lower lip (46.8%). Pulsed laser mode was used as standard and the number of applications varied from one to four sessions, with the majority requiring only one (83%) FDIP session. Kaplan-Meier analysis revealed that complete clinical healing can occur on the 15th day (n=9/29.5%), followed by the 20th (n=6/45.5%), and 30th (n=7/70.5%) days. Postoperative edema was observed in 31 (66%) patients, and recurrence of the lesion occurred in two (4.2%). Based on the data on complete clinical healing, minimal patient discomfort, and satisfactory esthetic results, we can confirm that FDIP by diode laser is a promising candidate for the safe and efficacious treatment of OVA. (OVA surgery Fortyseven Forty seven (FDIP 808 (80 nm45 nm 4 5 nm/4. W. W . W) 63.8% 638 63 8 (63.8% nonwhite non white 574 57 57. years 91.5%, 915 91.5% , 91 (91.5%) 6.4%, 64 6.4% 6 (6.4%) 2.1% 21 2 1 (2.1% 71 7 7. ±4.9 49 9 (±4.9 46.8%. 468 46.8% 46 (46.8%) sessions 83% 83 (83% session KaplanMeier Kaplan Meier th n=9/29.5%, n9295 n n=9/29.5% 29 (n=9/29.5%) n=6/45.5%, n6455 n=6/45.5% 45 (n=6/45.5%) n=7/70.5% n7705 70 (n=7/70.5% days 3 66% 66 (66% 4.2%. 42 4.2% (4.2%) discomfort results 80 (8 nm4 nm/4 63.8 (63.8 91.5 (91.5% 6.4 (6.4% 2.1 (2.1 ±4. (±4. 46.8 (46.8% (83 n929 n=9/29.5 (n=9/29.5% n645 n=6/45.5 (n=6/45.5% n=7/70.5 n770 (n=7/70.5 (66 4.2 (4.2% ( nm/ 63. (63. 91. (91.5 6. (6.4 2. (2. ±4 (±4 46. (46.8 n92 n=9/29. (n=9/29.5 n64 n=6/45. (n=6/45.5 n=7/70. n77 (n=7/70. (6 4. (4.2 (63 (91. (6. (2 ± (± (46. n9 n=9/29 (n=9/29. n6 n=6/45 (n=6/45. n=7/70 n7 (n=7/70 (4. (91 (46 n=9/2 (n=9/29 n=6/4 (n=6/45 n=7/7 (n=7/7 (4 (9 n=9/ (n=9/2 n=6/ (n=6/4 n=7/ (n=7/ n=9 (n=9/ n=6 (n=6/ n=7 (n=7 n= (n=9 (n=6 (n= (n

https://doi.org/10.1590/1807-3107bor-2024.vol38.0025

Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma XIIIa
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Flores, Isadora Luana

; de Arruda, José Alcides Almeida

; Abrantes, Thamiris de Castro

; Gamba, Thiago de Oliveira

; Abrahão, Aline Correa

; Anbinder, Ana Lia

; Ribeiro, Jaqueline Lemes

; Vasconcelos, Ana Carolina Uchoa

; Andrade, Bruno Augusto Benevenuto de

; Aguiar, Maria Cassia Ferreira de

; Gomes, Ana Paula Neutzling

; Abreu, Lucas Guimarães

; Mesquita, Ricardo Alves

Brazilian Oral Research

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2024, Volume 38 elocation e113

Abstract: En | Text: En | PDF: En

Abstract There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p<0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p<0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). The link between mast cell density, factor XIIIa+ dendrocytes, and inflammatory infiltrate indicates a potential crosstalk in lip carcinogenesis. skin However elastosisrelated elastosis related (AC , (LLSCC) unknown XIIIa assessed (2 lowgrade low grade 2 highgrade high dysplasia, dysplasia) 5 1 evaluated quantified intactdegranulated 5.9 59 9 (5. cells/mm2, cellsmm2 cellsmm cells/mm2 mm2 mm cells/mm2) 4.8 48 4 8 (4. cells/mm2. . p<0.001, p0001 p p<0.001 0 001 (p<0.001) p=0.005, p0005 p=0.005 005 (p=0.005) p<0.001. p=0.03 p003 03 (p=0.03 group 16.5 165 16 (16. carcinogenesis (LLSCC ( 5. (5 cells/mm 4. (4 p000 p<0.00 00 (p<0.001 p=0.00 (p=0.005 p=0.0 p00 (p=0.0 16. (16 p<0.0 (p<0.00 (p=0.00 p=0. p0 (p=0. (1 p<0. (p<0.0 p=0 (p=0 p<0 (p<0. p= (p= p< (p<0 (p (p<

https://doi.org/10.1590/1807-3107bor-2024.vol38.0113

10.

Diagnosis and prevalence of probable awake and sleep bruxism in adolescents: an exploratory analysis adolescents
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Prado, Ivana Meyer

; Abreu, Lucas Guimarães

; Pordeus, Isabela Almeida

; Amin, Maryam

; Paiva, Saul Martins

; Serra-Negra, Junia Maria

Brazilian Dental Journal

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jun 2023, Volume 34 N. 3 Pages 9 - 24

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os objetivos deste estudo foram realizar uma análise exploratória da prevalência de provável bruxismo em vigília (BV)e do sono (BS) utilizando diferentes critérios de diagnóstico baseados no Consenso Internacional; avaliar a associação entre o autorrelato e os sinais/sintomas clínicos em adolescentes. Participaram deste estudo transversal 403 adolescentes de 12 a 19 anos de idade matriculados em escolas públicas e privadas de Belo Horizonte, Brasil. Os pais/responsáveis responderam um questionário sobre dados sociodemográficos e estado de saúde dos adolescentes. Os adolescentes relataram atividades do BV (ranger e apertar) e BS (ranger, bracing e thrusting) e dores de cabeça frequentes. Um exame clínico foi realizado nos adolescentes para avaliar os sinais/sintomas clínicos do bruxismo (dor à palpação nos músculos masseter e temporal, marcas de endentação na língua e linha alba, desgaste dentário por atrição). Análises descritiva e teste Qui-quadrado de Pearson foram realizados (P≤0,05). A média de idade dos adolescentes foi de 14,3±1,5 anos e 58,1% eram do sexo feminino. O autorrelato de BS foi identificado em 31% dos participantes e o autorrelato do BV em 51,6%. Quase a totalidade dos adolescentes (99%) apresentaram pelo menos um dente com desgaste dentário (98,5% em esmalte; 0,5% em dentina), com média de 12,4±5,7 dentes acometidos. Dependendo do critério de diagnóstico, a prevalência do provável BS e BV variou de 0- 99% e 0,2- 99%, respectivamente. Uma grande inconsistência foi identificada na prevalência de provável BV e BS em adolescentes, que foram influenciadas pelos diferentes sinais/sintomas usados como critério de diagnóstico. Dores de cabeça frequentes e dor à palpação no masseter e temporal foram associados ao autorrelato de bruxismo em crianças e adolescentes. BVe (BS Internacional sinaissintomas sinais sintomas 40 1 Horizonte Brasil paisresponsáveis pais responsáveis ranger apertar ranger, thrusting alba atrição. atrição . atrição) Quiquadrado Qui quadrado P≤0,05. P005 P P≤0,05 0 05 (P≤0,05) 14315 14 3 5 14,3±1, 581 58 58,1 feminino 31 516 51 6 51,6% 99 (99% 98,5% 985 98 (98,5 esmalte 0,5 dentina, dentina , dentina) 12457 4 7 12,4±5, acometidos 0,2 02 2 respectivamente P00 P≤0,0 (P≤0,05 1431 14,3±1 58, 51,6 9 (99 98,5 (98, 0, 1245 12,4±5 P0 P≤0, (P≤0,0 143 14,3± 51, (9 98, (98 124 12,4± P≤0 (P≤0, 14,3 ( 12,4 P≤ (P≤0 14, 12, (P≤ (P

Abstract The aims of this study were to perform an exploratory analysis of probable awake (AB) and sleep bruxism (SB) prevalence using of different diagnosis criteria based on the International Consensus; evaluate the associations between self-report and clinical signs/symptoms in adolescents. Participated in this cross-sectional study 403 adolescents aged 12- to 19-years-old enrolled in public and private schools from Belo Horizonte, Brazil. Parents/caregivers answered a questionnaire about sociodemographic status and adolescents’ health status. Adolescents answered a questionnaire evaluating AB (e.g., grinding and clenching) and SB (e.g., grinding, bracing, and thrusting) activities and frequent headaches. A clinical examination was performed on adolescents to evaluate bruxism clinical signs/symptoms (pain upon palpation on masseter and temporal, linea alba, indentation on the tongue and attrition wear severity). Descriptive statistics and Pearson’s Qui-square test were performed (P≤0.05). Adolescents mean age was 14.3±1.5 years, and 58.1% were female. Self-report of SB was identified in 31% of participants and self-report of AB in 51.6%. Almost all adolescents (99%) presented at least one tooth with attrition wear (98.5% on enamel and 0.5% on dentin), with a mean number of 12.4±5.7 teeth. Depending on the diagnosis criteria, the prevalence of probable SB and AB varied from 0- 99% and 0.2- 99%, respectively. A high inconsistency was found for the prevalence of probable AB and SB in adolescents, which were influenced by the different clinical sings/symptoms used as diagnosis criteria. Frequent headaches and pain upon palpation on masseter and temporal muscle were associated to self-report of AB and SB among adolescents. (AB (SB Consensus selfreport self report signssymptoms signs symptoms crosssectional cross sectional 40 12 19yearsold yearsold 19 years old Horizonte Brazil Parentscaregivers Parents caregivers e.g., eg e g (e.g. clenching bracing thrusting alba severity. severity . severity) Pearsons Pearson s Quisquare Qui square P≤0.05. P005 P P≤0.05 0 05 (P≤0.05) 14315 14 3 1 5 14.3±1. 581 58 58.1 female Selfreport Self 31 516 51 6 51.6% 99 (99% 98.5% 985 98 (98.5 0.5 dentin, dentin , dentin) 12457 4 7 12.4±5. teeth 0.2 02 2 respectively singssymptoms sings e.g. (e.g P00 P≤0.0 (P≤0.05 1431 14.3±1 58. 51.6 9 (99 98.5 (98. 0. 1245 12.4±5 e.g P0 P≤0. (P≤0.0 143 14.3± 51. (9 98. (98 124 12.4± P≤0 (P≤0. 14.3 ( 12.4 P≤ (P≤0 14. 12. (P≤ (P

https://doi.org/10.1590/0103-6440202305202

11.

Semantic equivalence of the Brazilian version of the Patient Satisfaction Questionnaire (B-PSQ) BPSQ B PSQ (B-PSQ
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Gatti-Reis, Luisa

; Alvarenga, Renata Negreiros

; Abreu, Lucas Guimarães

; Paiva, Saul Martins

Brazilian Dental Journal

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feb 2023, Volume 34 N. 1 Pages 107 - 122

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O Patient Satisfaction Questionnaire (PSQ) é um instrumento autorrelatado específico para avaliar a satisfação de pacientes adolescentes com o tratamento ortodôntico. Um instrumento norte-americano pré-existente foi mais explorado na Holanda. A equivalência semântica faz parte da adaptação transcultural e é necessária para se obter um instrumento válido e confiável para uma cultura específica. O presente estudo teve como objetivo avaliar a equivalência semântica dos itens, subescalas e escore geral do PSQ entre a versão original em inglês e a versão em português do Brasil (B-PSQ). O PSQ possui 58 itens, distribuídos em 6 subescalas; relação médico-paciente, aspectos situacionais da clínica, melhora dentofacial, melhora psicossocial, função dentária e uma categoria residual. A equivalência semântica foi avaliada de acordo com o seguinte método: 1) traduções independentes para o português por dois tradutores, ambos nativos em português brasileiro e fluentes em inglês; 2) um comitê de experts elaborou a primeira versão síntese em português; 3) duas retro-traduções independentes para o inglês por dois tradutores nativos de língua inglesa fluentes em português; 4) revisão do comitê; 5) o comitê elaborou uma versão síntese das retro-traduções; 6) comitê de experts redigiu a segunda versão síntese em português; 7) pré-teste do instrumento por meio de entrevistas individuais semiestruturadas com 10 adolescentes; 8) revisão e versão final do B-PSQ. A equivalência semântica entre as versões original e brasileira do questionário foi alcançada por meio de métodos cuidadosos e rigorosos, com tradução eficaz e avaliações de experts, incorporando as opiniões da população-alvo. (PSQ ortodôntico norteamericano norte americano préexistente pré existente Holanda específica itens BPSQ. BPSQ B . (B-PSQ) 5 médicopaciente, médicopaciente médico paciente, paciente médico-paciente clínica dentofacial psicossocial residual método 1 2 3 retrotraduções retro 4 7 préteste teste 8 PSQ. B-PSQ rigorosos populaçãoalvo. populaçãoalvo população alvo. alvo população-alvo (B-PSQ

Abstract The Patient Satisfaction Questionnaire (PSQ) is a self-administered instrument to assess adolescent patients' satisfaction with orthodontic treatment. A pre-existing North American instrument was further explored in the Netherlands. Semantic equivalence is part of cross-cultural adaptation and is necessary to achieve a valid and reliable instrument for a specific culture. The present study aimed to evaluate the semantic equivalence of the items, subscales, and overall PSQ between the original English version and the Brazilian Portuguese language version (B-PSQ). The PSQ has 58 items, distributed across 6 subscales: doctor-patient relationship, situational aspects of the clinic, dentofacial improvement, psychosocial improvement, dental function, and a residual category. Semantic equivalence was evaluated according to the following methods: (1) independent translations to Portuguese by two translators, both native in Brazilian Portuguese and fluent in English; (2) an expert committee drafted the first summarized version in Portuguese; (3) two independent back-translations into English by two native English-speaking translators fluent in Portuguese; (4) committee review; (5) committee drafted a summarized version of the back-translations; (6) expert committee drafted the second summarized version in Portuguese; (7) pre-test of the instrument using individual semi-structured interviews with 10 adolescents; (8) review and final version of the B-PSQ. Semantic equivalence between the original and the Brazilian versions of the questionnaire was achieved through diligent and rigorous methods, with effective translation and expert evaluations, incorporating the opinions of the target population. (PSQ selfadministered self administered patients treatment preexisting pre existing Netherlands crosscultural cross cultural culture items subscales BPSQ. BPSQ B . (B-PSQ) 5 doctorpatient doctor patient relationship clinic improvement function category methods 1 (1 2 (2 3 (3 backtranslations back Englishspeaking speaking 4 (4 (5 (6 7 (7 pretest test semistructured semi structured adolescents 8 (8 PSQ. B-PSQ evaluations population (B-PSQ (

https://doi.org/10.1590/0103-6440202305074

12.

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System. (OMPLs SCC. . (SCC) crosssectional cross sectional North, North (North Northeast CentralWest, CentralWest Central West, West Central-West South. South South) 201 120010 120 010 120,01 20102019, 20102019 , (2010-2019) 69 6 9 6.9 8,321 8321 8 321 (8,32 0.8%, 08 0 (0.8% 95 cases, 4.9%, 49 4 (4.9% 5971 5 971 5,97 1.2%, 12 1 2 (1.2% 1399 399 1,39 Brazils s 64.5%, 645 64.5% 64 (64.5%) located men years level consumption group nonCaucasian non formercurrent former users Institute 99 9.9 Therefore System (SCC 20 12001 01 120,0 2010201 (2010-2019 6. 8,32 832 32 (8,3 0.8% (0.8 4.9% (4.9 597 97 5,9 1.2% (1.2 139 39 1,3 64.5 (64.5% 9. 1200 120, 201020 (2010-201 8,3 83 3 (8, 0.8 (0. 4.9 (4. 59 5, 1.2 (1. 13 1, 64. (64.5 20102 (2010-20 8, (8 0. (0 4. (4 1. (1 (64. (2010-2 ( (64 (2010- (6 (2010 (201 (20 (2

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

13.

Pathways that explain racial differences on edentulism among older adults: 2019 Brazil National Health Survey adults 201 20 2
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MENEGAZZO, Gabriele Rissotto

; CUNHA, Amanda Ramos da

; FAGUNDES, Maria Laura Braccini

; AMARAL JÚNIOR, Orlando Luiz do

; GIORDANI, Jessye Melgarejo do Amaral

; HILGERT, Juliana Balbinot

; ABREU, Lucas Guimarães

; HUGO, Fernando Neves

Brazilian Oral Research

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2023, Volume 37 elocation e40

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the pathways that explain the association between race/skin color and edentulism in elderly Brazilians. This was a cross-sectional study using data from participants aged 60 years or older from the 2019 Brazilian National Health Survey, a nationally representative population-based sample. Data were obtained by a structured interview and participants were classified as edentulous if they reported having lost all natural teeth. Information on race, socioeconomic level, behavioral aspects, psychosocial aspects, and access to dental care was collected by interviewers using a questionnaire. The pathways between race/skin color and edentulism were analyzed using structural equation modeling. The final sample of the study included 22,357 participants. Most participants were white (51.5%; 95% confidence interval [CI]: 50.3–52.6), and 36.8% (95%CI: 35.7–37.9) were edentulous. Race/skin color was indirectly associated with edentulism via enabling factors. These findings suggest that socioeconomic inequalities are key in explaining racial inequalities in edentulism among Brazilian older adults. raceskin race skin Brazilians crosssectional cross sectional 6 201 Survey populationbased population based teeth level aspects questionnaire modeling 22357 22 357 22,35 51.5% 515 51 5 (51.5% 95 CI [CI] 50.3–52.6, 503526 50.3–52.6 , 50 3 52 50.3–52.6) 368 36 8 36.8 95%CI 95CI (95%CI 35.7–37.9 357379 35 7 37 9 Raceskin Race factors adults 20 2235 2 22,3 51.5 (51.5 [CI 50352 50.3–52. 36. 35.7–37. 35737 223 22, 51. (51. 5035 50.3–52 35.7–37 3573 (51 503 50.3–5 35.7–3 (5 50.3– 35.7– ( 50.3 35.7 50. 35.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0040

14.

Effects of tobacco on the DNA of smokers and non-smokers affected by OSCC: systematic review and meta-analysis nonsmokers non OSCC metaanalysis meta analysis
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SCHUCH, Lauren Frenzel

; VIANA, Karolina Skarlet Silva

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; AGUIAR, Maria Cássia Ferreira de

; BERNARDES, Vanessa Fátima

Brazilian Oral Research

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2023, Volume 37 elocation e008

Abstract: En | Text: En | PDF: En

Abstract Scientific evidence about genetic and molecular changes in oral squamous cell carcinoma (OSCC) among smokers and non-smokers is inconclusive. This systematic review and meta-analysis assessed the effects of tobacco on the DNA of individuals with OSCC based on protein mutations. Electronic searches were conducted on PubMed, Ovid, Web of Science, and Scopus to identify observational studies published up to January/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. The certainty of the evidence was evaluated. Twenty-three studies assessing 4,060 individuals (2,967 smokers vs. 1,093 non-smokers) were included in this review. Fifteen groups of proteins/genes were investigated. Analysis of the quality of articles revealed low risk of bias in most studies. The certainty of the evidence was very low. The meta-analysis confirmed no significant difference between smokers and non-smokers with respect to damage to GSTM1 (OR: 0.60; 95%CI: 0.30–1.18), GSTT1 (OR: 1.18; 95%CI:0.49–2.83), hydrolase proteins (Ku70 and Ku80) (OR: 0.74; 95%CI: 0.18–3.05), and transferase proteins (GSTM1, GSTT1, GSTM3) (OR: 0.74; 95%CI: 0.47–1.18). Most of the studies included showed that smokers are more likely to exhibit genetic instability. However, the meta-analysis revealed that smokers do not necessarily have more genetic alterations in the DNA than non-smokers. (OSCC nonsmokers non inconclusive metaanalysis meta analysis mutations PubMed Ovid Science January2022 January 2022 January/2022 evaluated Twentythree Twenty three 4060 4 060 4,06 2,967 2967 2 967 (2,96 vs 1093 1 093 1,09 proteinsgenes genes investigated GSTM OR (OR 0.60 0 60 95%CI 95CI CI 95 0.30–1.18, 030118 0.30–1.18 , 30 18 0.30–1.18) GSTT 1.18 118 95%CI0.49–2.83, 95CI049283 0.49–2.83 49 83 95%CI:0.49–2.83) Ku70 Ku (Ku7 Ku80 0.74 074 74 0.18–3.05, 018305 0.18–3.05 3 05 0.18–3.05) GSTM1, (GSTM1 GSTM3 0.47–1.18. 047118 0.47–1.18 . 47 0.47–1.18) instability However nonsmokers. smokers. January202 202 January/202 406 06 4,0 2,96 296 96 (2,9 109 09 1,0 0.6 6 9 03011 0.30–1.1 1.1 11 CI0 95%CI0.49–2.83 95CI04928 049283 0.49–2.8 8 95%CI:0.49–2.83 Ku7 (Ku Ku8 0.7 07 7 01830 0.18–3.0 (GSTM 04711 0.47–1.1 January20 20 January/20 40 4, 2,9 29 (2, 10 1, 0. 0301 0.30–1. 1. 95%CI0.49–2.8 95CI0492 04928 0.49–2. 95%CI:0.49–2.8 0183 0.18–3. 0471 0.47–1. January2 January/2 2, (2 030 0.30–1 95%CI0.49–2. 95CI049 0492 0.49–2 95%CI:0.49–2. 018 0.18–3 047 0.47–1 January/ ( 03 0.30– 95%CI0.49–2 95CI04 049 0.49– 95%CI:0.49–2 01 0.18– 04 0.47– 0.30 95%CI0.49– 95CI0 0.49 95%CI:0.49– 0.18 0.47 0.3 95%CI0.49 0.4 95%CI:0.49 0.1 95%CI0.4 95%CI:0.4 95%CI0. 95%CI:0. 95%CI0 95%CI:0

https://doi.org/10.1590/1807-3107bor-2023.vol37.0008

15.

Dental anomalies in individuals with osteogenesis imperfecta: a systematic review and meta-analysis of prevalence and comparative studies imperfecta metaanalysis meta analysis
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PRADO, Heloisa Vieira

; SOARES, Enio Cássio Barreto

; CARNEIRO, Natália Cristina Ruy

; VILAR, Ivanete Cláudia de Oliveira

; ABREU, Lucas Guimarães

; BORGES-OLIVEIRA, Ana Cristina

Journal of Applied Oral Science

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2023, Volume 31 elocation e20230040

Abstract: En | Text: En | PDF: En

Abstract Background Osteogenesis imperfecta (OI) is a rare genetic disorder primarily caused by mutations in the genes involved in the production of type 1 collagen. OI is also known as brittle bone disease. Objective This study aims to describe the prevalence of dental anomalies (except dentinogenesis imperfecta) in individuals with OI, and compare the prevalence of dental anomalies between individuals with and without OI and between individuals with different types of OI. Search methods Searches in PubMed, Web of Science, Scopus, Ovid, and gray literature were performed in October 2022. Selection criteria Observational studies (with or without a comparison group) that evaluated the prevalence of dental anomalies in individuals with OI. Data collection and analysis: Data items were extracted by two authors. Quality assessment employing the Joanna Briggs Institute checklists and meta-analyses was conducted. Results were provided in prevalence values and odds ratio (OR) / 95% confidence interval (CI). Strength of evidence was determined. Results Eighteen studies were included. Most prevalent dental anomalies in individuals with OI included pulp obliteration (46.4%), dental impaction (33.5%), dental impaction of second molars (27%), and tooth agenesis (23.9%). Individuals with OI type III/IV had 20.16-fold greater chance of exhibiting tooth discoloration in comparison with individuals with OI type I (CI: 1.10–370.98). In comparison with the group without OI, the individuals with OI had 6.90-fold greater chance of exhibiting dental impaction (CI: 1.54–31.00). High methodological quality was found in 47% of the studies. Strength of evidence was low or very low. Conclusions Pulp obliteration, dental impaction, and tooth agenesis were the most prevalent dental anomalies in the OI group. Individuals with OI were more likely to have dental impaction than individuals without OI. Individuals with OI type III/IV (severe-moderate) are more likely to have tooth discoloration than individuals with OI type I (mild). (OI collagen disease except PubMed Science Scopus Ovid 2022 analysis authors metaanalyses meta analyses conducted OR (OR 95 CI. CI . (CI) determined 46.4%, 464 46.4% , 46 4 (46.4%) 33.5%, 335 33.5% 33 5 (33.5%) 27%, 27 27% (27%) 23.9%. 239 23.9% 23 9 (23.9%) IIIIV III IV 20.16fold 2016fold fold 20.16 20 16 (CI 1.10–370.98. 11037098 1.10–370.98 10 370 98 1.10–370.98) 6.90fold 690fold 6.90 6 90 1.54–31.00. 1543100 1.54–31.00 54 31 00 1.54–31.00) 47 severemoderate severe moderate (severe-moderate mild. mild (mild) 202 46.4 (46.4% 33.5 3 (33.5% 2 (27% 23.9 (23.9% 16fold 2016 20.1 1103709 1.10–370.9 37 90fold 690 6.9 154310 1.54–31.0 0 (mild 46. (46.4 33. (33.5 (27 23. (23.9 201 20. 110370 1.10–370. 69 6. 15431 1.54–31. (46. (33. (2 (23. 11037 1.10–370 1543 1.54–31 (46 (33 ( (23 1103 1.10–37 154 1.54–3 (4 (3 110 1.10–3 15 1.54– 11 1.10– 1.54 1.10 1.5 1.1 1.

https://doi.org/10.1590/1678-7757-2023-0040

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