Abstract Objectives Medical training negatively impacts the quality of life of students. Assessing the well-being of medical students could guide academic policies and future research for improving the mental and physical health status of the population at risk. This study aimed to identify the influence of medical training on the quality of life of Brazilian medical students. Methods A systematic review and meta-analysis was conducted according to the Cochrane criteria and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol (PRISMA). The search was performed by two independent investigators using a predefined protocol registered on the PROSPERO database (CRD42021237926). Data were extracted from PubMed, Embase, and Biblioteca Virtual de Saúde (BVS). For quantitative synthesis, a meta-analysis was conducted to assess the mean difference in the quality of life between medical students at different stages in the academic cycle, stratified by sex. All data were analyzed using the random-effects model, with a confidence interval of 95% (95%CI). Results After evaluating the eligibility criteria, five studies were included in the meta-analysis. The data revealed that students in the pre-clinical cycle of the course exhibited higher quality of life scores in the physical (3.05 [1.48-4.62], p < 0.0001) and psychological (3.05 [0.80-5.30], p < 0.0001) domains than students in the clerkship cycle. No statistically significant differences were observed in the environmental (0.78 [-2.92-4.49], p = 0.68) or social domains (1.41 [-0.52-3.34], p = 0.15). Conclusion Our analysis revealed that the medical course is associated with decreased quality of life of medical students in the physical and psychological domains. This finding was observed in both men and women. However, these findings should be interpreted with caution given the study limitations. Registration number PROSPERO, CRD42021237926. wellbeing well being risk metaanalysis meta MetaAnalyses Meta Analyses PRISMA. PRISMA . (PRISMA) CRD42021237926 CRD (CRD42021237926) PubMed Embase BVS. BVS (BVS) synthesis sex randomeffects random effects model 95 95%CI. 95CI CI 95%CI (95%CI) metaanalysis. analysis. preclinical pre clinical 3.05 305 3 05 (3.0 1.484.62, 148462 1.48 4.62 , 1 48 4 62 [1.48-4.62] 0.0001 00001 0 0001 0.805.30, 080530 0.80 5.30 80 5 30 [0.80-5.30] 0.78 078 78 (0.7 2.924.49, 292449 2.92 4.49 2 92 49 [-2.92-4.49] 0.68 068 68 1.41 141 41 (1.4 0.523.34, 052334 0.52 3.34 52 34 [-0.52-3.34] 0.15. 015 0.15 15 0.15) women However limitations (PRISMA CRD4202123792 (CRD42021237926 (BVS 9 (95%CI 3.0 (3. 484 1.484.62 14846 148 1.4 462 4.6 6 [1.48-4.62 0.000 0000 000 805 0.805.30 08053 080 0.8 530 5.3 8 [0.80-5.30 0.7 07 7 (0. 924 2.924.49 29244 292 2.9 449 4.4 [-2.92-4.49 0.6 06 14 (1. 523 0.523.34 05233 052 0.5 334 3.3 [-0.52-3.34 01 0.1 CRD420212379 (CRD4202123792 3. (3 1.484.6 1484 1. 46 4. [1.48-4.6 0.00 00 0.805.3 0805 08 0. 53 5. [0.80-5.3 (0 2.924.4 2924 29 2. 44 [-2.92-4.4 (1 0.523.3 0523 33 [-0.52-3.3 CRD42021237 (CRD420212379 ( 1.484. [1.48-4. 0.0 0.805. [0.80-5. 2.924. [-2.92-4. 0.523. [-0.52-3. CRD4202123 (CRD42021237 1.484 [1.48-4 0.805 [0.80-5 2.924 [-2.92-4 0.523 [-0.52-3 CRD420212 (CRD4202123 [1.48- [0.80- [-2.92- [-0.52- CRD42021 (CRD420212 [1.48 [0.80 [-2.92 [-0.52 CRD4202 (CRD42021 [1.4 [0.8 [-2.9 [-0.5 CRD420 (CRD4202 [1. [0. [-2. [-0. CRD42 (CRD420 [1 [0 [-2 [-0 CRD4 (CRD42 [ [- (CRD4 (CRD

Abstract Introduction The Iowa-Netherlands Comparison Orientation Measure (INCOM) was developed to measure individual differences in social comparison orientation and has been widely used in research and various different settings. Objectives The aim of this study was to adapt the online version of the INCOM and to evaluate its psychometric parameters when applied to a Brazilian population of university students. Methods The procedures were divided into two steps: step 1 – cross-cultural adaptation and analysis of content validity, and step 2 – assessment of psychometric characteristics. Step 1 comprised the processes of translation, evaluation by an expert committee, evaluation by the target population, and back-translation. For step 2, 1,065 university students were recruited and then factor analysis, analysis of reliability, and analysis of validity based on external measures were performed. Results The adaptation process yielded satisfactory results, including good indicators of content validity. Exploratory factor analysis revealed a two-dimensional structure and adequate factor loadings, except for item 11, which was excluded from the final version. Additionally, the final version of the scale had adequate fit indices (χ2 = 148.45, degrees of freedom [df] = 26; p < 0.001; root mean square error of approximation [RMSEA] = 0.06; comparative fit index [CFI] = 0.99; and Tucker-Lewis index [TLI] = 0.98). Evidence of reliability (Cronbach’s alpha = 0.83) was observed and there were positive correlations with negative affect (r = 0.36) and negative correlations with positive affect and self-esteem (r = -0.15; r = -0.41, respectively). Conclusion The Brazilian version of the INCOM presents satisfactory psychometric parameters and can thus be used to measure social comparison orientation. IowaNetherlands Iowa Netherlands (INCOM settings steps crosscultural cross cultural characteristics translation committee backtranslation. backtranslation back translation. back-translation 1065 065 1,06 performed results twodimensional dimensional loadings 11 Additionally χ2 χ (χ 14845 148 45 148.45 df [df 26 0.001 0001 0 001 RMSEA [RMSEA 0.06 006 06 CFI [CFI 0.99 099 99 TuckerLewis Tucker Lewis TLI [TLI 0.98. 098 0.98 . 98 0.98) Cronbachs Cronbach s 0.83 083 83 0.36 036 36 selfesteem self esteem 0.15 015 15 -0.15 0.41, 041 41 -0.41 respectively. respectively respectively) 106 1,0 1484 14 4 148.4 0.00 000 00 0.0 0.9 09 9 0.8 08 8 0.3 03 3 0.1 01 -0.1 0.41 04 -0.4 10 1, 148. 0. -0. 0.4 -0 -

Abstract Objective To investigate the role of optimism, hope, and gratitude as psychosocial factors for healthy development, especially with regard to anxiety in college students in the context of coronavirus disease 2019 (COVID-19). Methods This is a quantitative, descriptive cross-sectional study. A sociodemographic questionnaire, the Brazilian Gratitude Scale (Escala Brasileira de Gratidão [B-GRAT]), and the Brazilian versions of an anxiety subscale, the Revised Life Orientation Test (LOT-R), Hope Index Scale, and BIG-FIVE were administered. Data were analyzed using the Mann-Whitney U test, the Kruskal-Wallis test, Spearman correlations, and hierarchical linear regression. Results A total of 297 students were assessed. The relationship between gratitude and anxiety became positive in the hierarchical linear analysis, contradicting the initial negative association between these variables according to the Spearman coefficients. This contradiction may be a result of the suppression effect. When gratitude was added to the model, these three variables together accounted for 38% of the variance in anxiety. This indicates that optimism, hope, and gratitude together are significant predictors, although optimism alone accounts for the greater part of the variance in decreased anxiety. Conclusion The data confirm that family and religiosity are protective factors against mental illness, specifically non-adaptive anxiety. Furthermore, developing optimism as a protective factor makes it possible to experience less anxiety while hope has the potential to provide the individual with multiple pathways to healthy development. This study highlights that gratitude plays a dual role in these relationships as it has the potential to be associated with anxious feelings with likely negative outcomes while at the same time it can drive positive psychosocial factors of optimism and hope, decreasing anxiety. development 201 COVID19. COVID19 COVID 19 . (COVID-19) quantitative crosssectional cross sectional questionnaire Escala BGRAT, BGRAT B GRAT , [B-GRAT]) subscale LOTR, LOTR LOT R (LOT-R) BIGFIVE BIG FIVE administered MannWhitney Mann Whitney test KruskalWallis Kruskal Wallis correlations regression 29 assessed analysis coefficients effect model 38 predictors illness nonadaptive non adaptive Furthermore 20 COVID1 1 (COVID-19 [B-GRAT] (LOT-R 2 3 (COVID-1 [B-GRAT (COVID- (COVID

Abstract Objective Existing scales that seek to measure alterations in self-experience were developed based on studies conducted in developed countries. Therefore, the aim of this study was to evaluate the psychometric properties of the Ego Dissolution Inventory (EDI) after translating and adapting it for the Brazilian context. Methods The measure was translated by two translators fluent in both English and Portuguese, followed by back-translation into English to ensure there was no loss of meaning. The scale was used in an online survey exploring substance use. A total of 528 participants answered the full scale. We calculated the Kaiser-Meyer-Olkin (KMO) measure to evaluate sampling adequacy, then ran exploratory factor analysis (EFAs) to investigate the factor structure of the EDI. Results The scale showed acceptable psychometric properties, with excellent internal consistency and sampling adequacy for factor analysis. Kaiser-Guttman’s criteria and Hull’s method indicated a three-factor solution, while parallel analysis suggested a two-factor solution. All items showed salient loadings, with two items exhibiting cross-loading. Positive but weak correlations were found between EDI factors 1 and 2 and nature relatedness. Conclusions The validated scale showed solid psychometric properties, with potential differences in factor structure in relation to the English version. Considering validation is an ongoing process, it is recommended that studies be conducted comparing ego dissolution scores across distinct substances and different regions of the country. selfexperience self experience countries Therefore (EDI context Portuguese backtranslation back translation meaning use 52 KaiserMeyerOlkin Kaiser Meyer Olkin KMO (KMO EFAs (EFAs KaiserGuttmans Guttman s Hulls Hull threefactor three solution twofactor loadings crossloading. crossloading cross loading. loading cross-loading relatedness version process country 5

Abstract Objective This systematic review aims to describe the relationship between psychological resilience and mood disorders. Methods This is a systematic review and meta-analysis. The following databases were searched on November 6, 2020: PubMed, PsycINFO, and Embase. Results Twenty-three articles were included and the majority of the studies included (95.7%) showed that psychological resilience has a positive impact in mood disorders. Our meta-analysis showed that individuals with bipolar disorder presented significantly lower levels of psychological resilience compared to controls (standardized mean difference [SDM]: -0.99 [95% confidence interval {95%CI}: -1.13 to -0.85], p < 0.001). In addition, individuals with depression had significantly lower levels of psychological resilience compared to controls (SDM: -0.71 [95%CI -0.81 to -0.61], p < 0.001). Conclusion Our results showed that individuals with mood disorders are less resilient than individuals without mood disorders. Our findings reinforce the importance of investigating interventions that may help to improve psychological resilience considering its positive impact in the context of mood disorders. metaanalysis. metaanalysis meta analysis. analysis 6 2020 PubMed PsycINFO Embase Twentythree Twenty three 95.7% 957 95 7 (95.7% standardized SDM [SDM] 0.99 099 0 99 -0.9 95% [95 95%CI 95CI CI {95%CI} 1.13 113 1 13 -1.1 0.85, 085 0.85 , 85 -0.85] 0.001. 0001 0.001 . 001 0.001) addition (SDM 0.71 071 71 -0.7 0.81 081 81 -0.8 0.61, 061 0.61 61 -0.61] 202 95.7 9 (95.7 [SDM 0.9 09 -0. [9 {95%CI 1.1 11 -1. 08 0.8 8 -0.85 000 0.00 00 0.7 07 06 0.6 -0.61 20 95. (95. 0. -0 [ 1. -1 0.0 -0.6 2 (95 - (9 (

Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects. (ASD behavior effects option CBD (CBD randomized doubleblind, doubleblind double blind, blind double-blind placebocontrolled placebo controlled trial 6 1 years groups CBDrich weeks twofactor factor twoway way ANOVA. ANOVA . ANOVA) F1,116 F1116 F F1 116 (F1,11 1413 14 13 14.13 0.0002, 00002 0.0002 , 0 0002 0.0002) 599 99 5.99 0.016, 0016 0.016 016 0.016) 922 9 22 9.22 0.003, 0003 0.003 003 0.003) 411 4 4.11 0.04, 004 0.04 04 0.04) F1,48 F148 48 (F1,4 675 75 6.75 0.01, 001 0.01 01 0.01) cases 9.7% 97 7 (9.7% dizziness insomnia colic gain interaction, interaction) coexist co exist F1,11 F111 (F1,1 141 14.1 0000 0.000 000 59 5.9 92 2 9.2 0.00 00 41 4.1 0.0 F1,4 F14 (F1, 67 6.7 9.7 (9.7 F1,1 F11 14. 5. 9. 4. 0. F1, (F1 6. (9. (F (9 (

Abstract Objectives The emergence of the coronavirus disease 2019 (COVID-19) pandemic and subsequent lockdowns and social distancing measures adopted worldwide raised questions about the possible health effects of human social isolation. Methods We conducted a systematic review on PubMed, Scopus, and Embase electronic databases using terms related to human social isolation – defined as the isolation of an individual from regular routines and usual social contact – and psychological stress, searching for simulated or naturalistic isolation environments. We present the main results, as well as the validity and limitations of each model. PROSPERO registry number: CRD42021241880. Results Despite the diversity of contexts reviewed, some outcomes almost ubiquitously relate to psychological stress, i.e., longer periods, expectation of a longer period, confinement, lack of social interaction, and support. Based on the results, and considering that most studies were not designed for the purpose of understanding isolation itself, we propose a group of recommendations for future experimental or naturalistic research on the topic. Conclusion Evidence on the impact of different situations in which individuals are subjected to social isolation can assist in development of directed preventive strategies to support people under similar circumstances. Such strategies might increase the general public’s compliance with social distancing as a non-pharmacological intervention for emerging infectious diseases. 201 COVID19 COVID 19 (COVID-19 PubMed Scopus stress environments results model number CRD42021241880 CRD reviewed ie i e i.e. periods period confinement interaction itself topic circumstances publics public s nonpharmacological non pharmacological diseases 20 COVID1 1 (COVID-1 CRD4202124188 i.e 2 (COVID- CRD420212418 (COVID CRD42021241 CRD4202124 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

Abstract Background Teaching is very stressful and demanding and it intensifies psychological and related disorders compared to other occupations. Most teachers in Nigeria are battling emotional distress, burnout, depression, and anxiety due to excess workload, which has affected their psychological well-being. This study assessed the sociodemographic and psychological well-being of primary school teachers in Enugu State, Nigeria. Methods This is a study with a cross-sectional design. The psychological well-being of 254 primary school teachers was assessed using a psychological well-being scale and a sociodemographic information inventory was also used to ascertain their personal information. The data collected were analyzed using chi-square, mean, standard deviation, and bivariate correlation statistics. Results The results showed that the majority of primary school teachers experience unhealthy psychological well-being irrespective of age, gender, working status, qualification, and years of teaching experience. These teachers’ sociodemographic variables are significantly correlated with psychological well-being. Only location is not significantly correlated with psychological well-being. Conclusion Therefore, this study concluded that primary school teachers’ psychological well-being is not positive or healthy and is significantly related to their sociodemographic characteristics. occupations distress burnout depression workload wellbeing. wellbeing well being. being State crosssectional cross sectional design 25 chisquare, chisquare chi square, square chi-square mean deviation statistics age gender status qualification Therefore characteristics 2

Abstract Objective Childhood maltreatment is extremely harmful to health, especially in relation to development of the psychiatric disorders throughout life. The objective of this study was to describe the prevalence and types of maltreatment in a sample of adolescent schoolchildren and to investigate associations between maltreatment types and anxiety and depressive symptoms, sociodemographic variables, and risk behaviors. The study also identified which variables were the greatest predictors of anxiety and depressive symptoms. Methods We conducted a cross-sectional study with a sample of 654 school students aged 11 to 17 years. We collected sociodemographic data and administered the Revised Child Anxiety and Depression Scale (RCADS-47) to measure anxiety and depressive symptoms as well as the Childhood Trauma Questionnaire (CTQ) to evaluate maltreatment and adverse experiences such as abuse and negligence during childhood and adolescence. Statistical analyses were conducted to estimate correlations between sociodemographic data, anxiety, depression, and types of maltreatment. A regression analysis was also conducted to identify maltreatment types that predict psychological symptoms. Results Emotional abuse and emotional neglect were the most prevalent types of maltreatment. Statistically, emotional abuse was the maltreatment type most strongly correlated with depression and anxiety and tended to co-occur with other types of maltreatment. Additionally, emotional and sexual abuse were the greatest predictors of anxiety and depression in adolescents. Conclusion The above results reinforce the findings of previous studies in terms of understanding the effects of maltreatment. They identify emotional abuse as the main predictor of depressive and anxiety symptoms. health life behaviors crosssectional cross sectional 65 1 years RCADS47 RCADS 47 (RCADS-47 CTQ (CTQ adolescence Statistically cooccur co occur Additionally adolescents 6 RCADS4 4 (RCADS-4 (RCADS- (RCADS

Abstract Objectives: Intimate partner violence (IPV) increased extensively around the world during the pandemic, causing severe harm to women's mental health. However, there are no studies showing these effects in Brazil. The objectives of this study were to assess perpetration of IPV and presence of depression and suicidal ideation in women living in Brazil during the coronavirus disease 2019 (COVID-19) pandemic. Methods: Cross-sectional online survey including women living in Brazil from July 2020 to June 2021. Participants answered a 43-item self-administered questionnaire exploring their characteristics and life changes due to the pandemic (CoRonavIruS Health Impact Survey [CRISIS]), IPV (World Health Organization Violence Against Women [WHO-VAW]), and depressive symptoms or suicidal ideation (Patient Health Questionnaire-9 [PHQ-9]). We used Poisson multiple regression analyses with robust variance to model associations between IPV and mental health outcomes, considering aspects of social vulnerability as covariates. Results: We found high frequencies of IPV (33.3%), depression (36.1%), and suicidal ideation (19.8%) among the participants. IPV was significantly associated with depression (prevalence ratio [PR] = 1.502, p = 0.001 for one type of IPV; PR = 2.702, p < 0.001 for two or three types of IPV) and with suicidal ideation (PR = 2.264, p < 0.001 for one type of VPI; PR = 3.272, p < 0.001 for two or three types of IPV). Food insecurity, being black, lower educational levels, and being in a relationship with a person of the same gender were associated with one or both mental health outcomes. Conclusions: We demonstrated associations between IPV and higher frequencies of depression and suicidal ideation in women living in Brazil during the COVID-19 pandemic, highlighting the urgency of strengthening strategies to protect women during adversity. Objectives (IPV womens s However 201 COVID19 COVID 19 (COVID-19 Methods Crosssectional Cross sectional 202 2021 43item item 43 selfadministered self administered CoRonavIruS CRISIS, CRISIS , [CRISIS]) World WHOVAW, WHOVAW WHO VAW [WHO-VAW]) Patient Questionnaire9 Questionnaire 9 Questionnaire- PHQ9. PHQ9 PHQ . [PHQ-9]) outcomes covariates Results 33.3%, 333 33.3% 33 3 (33.3%) 36.1%, 361 36.1% 36 1 (36.1%) 19.8% 198 8 (19.8% participants prevalence [PR 1502 502 1.502 0001 0 001 0.00 2702 2 702 2.702 2264 264 2.264 VPI 3272 272 3.272 IPV. insecurity black levels Conclusions COVID-1 adversity 20 COVID1 (COVID-1 4 [CRISIS] [WHO-VAW] [PHQ-9] 33.3 (33.3% 36.1 (36.1% 19.8 (19.8 150 50 1.50 000 00 0.0 270 70 2.70 226 26 2.26 327 27 3.27 COVID- (COVID- [CRISIS [WHO-VAW [PHQ-9 33. (33.3 36. (36.1 19. (19. 15 5 1.5 0. 7 2.7 22 2.2 32 3.2 (COVID [PHQ- (33. (36. (19 1. 2. 3. [PHQ (33 (36 (1 (3 (

Abstract Eating disorders (ED) are a group of potentially severe mental disorders characterized by abnormal energy balance, cognitive dysfunction, and emotional distress. Cognitive inflexibility is a major challenge to successful ED treatment and dysregulated serotonergic function has been implicated in this symptomatic dimension. Moreover, there are few effective treatment options and long-term remission of ED symptoms is difficult to achieve. There is emerging evidence for the use of psychedelic-assisted psychotherapy (PAP) for a range of mental disorders. Psilocybin is a serotonergic psychedelic that has demonstrated therapeutic benefit in a variety of psychiatric illnesses characterized by rigid thought patterns and treatment resistance. The current paper presents a narrative review of the hypothesis that psilocybin may be an effective adjunctive treatment for individuals with EDs, based on biological plausibility, transdiagnostic evidence, and preliminary results. Limitations of the PAP model and proposed future directions for its application to eating behavior are also discussed. Although the literature to date is not sufficient to propose the incorporation of psilocybin in the treatment of disordered eating behaviors, preliminary evidence supports the need for more rigorous clinical trials as an important avenue for future investigation. (ED balance dysfunction distress dimension Moreover longterm long term achieve psychedelicassisted assisted (PAP resistance EDs plausibility results discussed behaviors investigation

Abstract Objective: Food intake during binge eating episodes (BEE) has been found to be associated with symptoms of depression and anxiety in individuals with eating disorders (EDs). The objective of this study was to evaluate the association between caloric intake during BEE and psychopathology in individuals with binge eating spectrum disorders (BSD). Methods: One-hundred and fourteen outpatients diagnosed with bulimia nervosa (BN) and binge eating disorder (BED) were sequentially assessed. The Mini International Neuropsychiatric Interview Plus (MINI PLUS) was used to assess psychiatric diagnoses. Validated self-report instruments were used to assess general and eating-related psychopathology. The Dietpro Clinical Program® was used for assessment of calorie consumption during BEE. Data were analyzed with independent Student's t tests, effect size (Cohen's d), and Pearson's correlation coefficients. Results: Participants with BSD comorbid with a depressive disorder consumed significantly more calories during BEE than those without depression. Furthermore, participants with BSD and higher levels of impulsivity had higher caloric intake during episodes. Specifically regarding BN, participants with greater disease severity consumed more calories during episodes than those with lesser severity. Conclusion: Overall, depression and high impulsivity were associated with higher caloric intake during BEE in individuals with BSD. For those with BN, disease severity was associated with greater calorie consumption during episodes. Our results support the relevance of early identification of psychiatric comorbidities and implementation of strategies to control mood and impulsivity, aiming for better prognosis in the treatment of BSD. Objective (BEE EDs. EDs . (EDs) (BSD) Methods Onehundred One hundred BN (BN BED (BED assessed MINI PLUS diagnoses selfreport self report eatingrelated related Program Students Student s tests Cohens Cohen d, d , d) Pearsons Pearson coefficients Results Furthermore Conclusion Overall (EDs (BSD

Abstract Objectives: There has been growing concern about the long-term effects of coronavirus disease 2019 (COVID-19) on mental health. The biological factors common to psychiatric conditions and COVID-19 are not yet fully understood. Methods: We narratively reviewed prospective longitudinal studies that measured metabolic or inflammatory markers and assessed psychiatric sequelae and cognitive impairment in individuals with COVID-19 at least 3 months after infection. A literature search identified three relevant cohort studies. Results: Overall, depressive symptomatology and cognitive deficits persisted for up to 1 year after COVID-19; depression and cognitive changes were predicted by acute inflammatory markers, and changes in these markers correlated with changes in depressive symptomatology; female sex, obesity, and the presence of inflammatory markers were associated with more severe clusters of physical and mental health status in patients’ self-perceived recovery; and plasma metabolic profiles of patients continued to differ from those of healthy controls 3 months after hospital discharge, which were associated with widespread alterations in neuroimaging, reflecting issues with white matter integrity. Conclusion: In individuals affected by COVID-19, prolonged exposure to stress and alterations in metabolic and inflammatory markers play a central role in psychiatric sequelae and cognitive deficits in the long term. Objectives longterm term 201 COVID19 COVID 19 (COVID-19 COVID-1 understood Methods infection Results Overall sex obesity selfperceived self perceived recovery discharge neuroimaging integrity Conclusion COVID19, 19, 20 COVID1 (COVID-1 COVID- 2 (COVID- (COVID