SUMMARY OBJECTIVE: This study was conducted to determine the effect of relaxation exercise on fatigue symptoms in hemodialysis patients. METHODS: This is a meta-analysis study. The literature review was carried out by searching studies published between 2011 and 2020. This meta-analysis was recorded on PROSPERO in the National Health Research Institute (Registration no: CRD42022313646). RESULTS: Seven studies meeting the inclusion criteria were included in the meta-analysis. The effect size of the studies included in the meta-analysis was found to be g=1.232 (p=0.028), which indicated a "huge effect size." The scale used in the subgroup analyses, the application time of the relaxation exercise, and the number of relaxation exercise applications were evaluated, and a significant difference was found at p<0.05. CONCLUSION: Relaxation exercises can be used as an effective method for reducing fatigue in hemodialysis patients. OBJECTIVE patients METHODS metaanalysis meta analysis 201 2020 Registration no CRD42022313646. CRD42022313646 CRD . CRD42022313646) RESULTS metaanalysis. analysis. g1232 g 1 232 g=1.23 p=0.028, p0028 p p=0.028 , 0 028 (p=0.028) huge size. analyses evaluated p005 05 p<0.05 CONCLUSION 20 202 CRD4202231364 g123 23 g=1.2 p002 p=0.02 02 (p=0.028 p00 p<0.0 2 CRD420223136 g12 g=1. p=0.0 (p=0.02 p0 p<0. CRD42022313 g1 g=1 p=0. (p=0.0 p<0 CRD4202231 g= p=0 (p=0. p< CRD420223 p= (p=0 CRD42022 (p= CRD4202 (p CRD420 CRD42 CRD4

SUMMARY OBJECTIVE: The aim of our study was to determine the role of serum glucose–potassium ratio in predicting inhospital mortality in coronary care unit patients. METHODS: This study used data from the MORtality in CORonary Care Units in Turkey study, a national, observational, multicenter study that included all patients admitted to coronary care units between September 1, 2022, and September 30, 2022. Statistical analyses assessed the independent predictors of mortality. Two models were created. Model 1 included age, history of heart failure, chronic kidney disease, hypertension, diabetes mellitus, and coronary artery disease. Model 2 included glucose–potassium ratio in addition to these variables. Multivariate regression and receiver operating characteristic analysis were performed to compare Model 1 and Model 2 to identify if the glucose–potassium ratio is an independent predictor of inhospital mortality. RESULTS: In a study of 3,157 patients, the mortality rate was 4.3% (n=137). Age (p=0.002), female gender (p=0.004), mean blood pressure (p<0.001), serum creatinine (p<0.001), C-reactive protein (p=0.002), white blood cell (p=0.002), and glucose–potassium ratio (p<0.001) were identified as independent predictors of mortality through multivariate regression analysis. The receiver operating characteristic analysis indicated that Model 2 had a statistically higher area under the curve than Model 1 (area under the curve 0.842 vs area under the curve 0.835; p<0.001). A statistically significant correlation was found between the inhospital mortality and glucose–potassium ratio (OR 1.015, 95%CI 1.006–1.024, p<0.001). CONCLUSION: Our study showed that the glucose–potassium ratio may be a significant predictor of inhospital mortality in coronary care unit patients. OBJECTIVE glucosepotassium glucose potassium METHODS national observational 2022 30 created age failure disease hypertension mellitus variables RESULTS 3157 3 157 3,15 43 4 4.3 n=137. n137 n n=137 . 137 (n=137) p=0.002, p0002 p p=0.002 , 0 002 (p=0.002) p=0.004, p0004 p=0.004 004 (p=0.004) p<0.001, p0001 p<0.001 001 Creactive C reactive (p<0.001 0842 842 0.84 0.835 0835 835 p<0.001. p<0.001) OR 1015 015 1.015 95CI CI 95 10061024 006 024 1.006–1.024 CONCLUSION 202 315 15 3,1 4. n13 n=13 13 (n=137 p000 p=0.00 00 (p=0.002 (p=0.004 p<0.00 (p<0.00 084 84 0.8 0.83 083 83 101 01 1.01 9 1006102 02 1.006–1.02 20 31 3, n1 n=1 (n=13 p00 p=0.0 (p=0.00 p<0.0 (p<0.0 08 8 0. 10 1.0 100610 1.006–1.0 n= (n=1 p0 p=0. (p=0.0 p<0. (p<0. 1. 10061 1.006–1. (n= p=0 (p=0. p<0 (p<0 1006 1.006–1 (n p= (p=0 p< (p< 100 1.006– (p= (p 1.006 1.00

SUMMARY OBJECTIVE: Phyllodes tumors in the breast are exceptionally uncommon fibroepithelial tumors. In the literature, they are typically categorized as benign phyllodes tumor, borderline phyllodes tumor, and malignant phyllodes tumor. This study aims to assess and present the clinical and surgical outcomes of patients diagnosed with phyllodes tumor. METHODS: The outcomes of patients aged 18 years and above diagnosed with phyllodes tumor between 2006 and 2023 were retrospectively reviewed. Patients were grouped as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared by clinical and surgical results. RESULTS: Of all 57 patients with phyllodes tumor, 64.9% (n=37) were benign phyllodes tumor and 35.1% (n=20) were borderline/malignant phyllodes tumor [22.8% (n=13) borderline phyllodes tumor and 12.3% (n=7) malignant phyllodes tumor]. When the patients were divided into two groups as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared, our cumulative (total) recurrence rate was 14.0%, with final surgical margin width between groups [(0<final surgical margin<2 mm vs final surgical margin≥2 mm) (p=0.154)] and recurrence [(8.1% benign phyllodes tumor vs 25.0% borderline/malignant phyllodes tumor) (p=0.080)]; there was no significant difference between our rates. CONCLUSION: Phyllodes tumors of the breast can be followed up with a narrow negative surgical margin (0 mm<final surgical margin<2 mm). However, after the initial surgery, re-excision is recommended for positive margins, while a wider surgical margin (≥10 mm) is not necessary for excision. OBJECTIVE literature METHODS 1 200 202 reviewed borderlinemalignant results RESULTS 5 649 64 9 64.9 n=37 n37 n 37 (n=37 351 35 35.1 n=20 n20 20 (n=20 22.8% 228 22 8 [22.8 n=13 n13 13 (n=13 123 12 3 12.3 n=7 n7 7 (n=7 . tumor] total (total 140 14 0 14.0% 0<final 0final margin2 2 margin< margin≥ p=0.154 p0154 p 154 (p=0.154) 8.1% 81 [(8.1 250 25 25.0 p=0.080 p0080 080 (p=0.080)] rates CONCLUSION ( mmfinal mm. However surgery reexcision re excision margins ≥10 10 (≥1 6 64. n=3 n3 (n=3 35. n=2 n2 (n=2 22.8 [22. n=1 n1 (n=1 12. n= (n= 14.0 p=0.15 p015 15 (p=0.154 8.1 [(8. 25. p=0.08 p008 08 (p=0.080) ≥1 (≥ 22. [22 (n 14. p=0.1 p01 (p=0.15 8. [(8 p=0.0 p00 (p=0.080 ≥ [2 p=0. p0 (p=0.1 [( (p=0.08 [ p=0 (p=0. (p=0.0 p= (p=0 (p= (p

SUMMARY OBJECTIVE: Pregnancy, childbirth, and postpartum periods bring along biological, psychological, and social changes that could affect women's sexual health. The aim of this study was to evaluate the effect of genital self-image on sexual satisfaction and stress in women who had a vaginal delivery. METHODS: This descriptive and cross-sectional study was conducted online between June and September 2023 by using snowball sampling and the data collection forms prepared in the GoogleDocs program. Women who had a normal vaginal delivery were included, were within 6 weeks to 1 year postpartum, were able to use at least one of the social media networks (e-mail, WhatsApp, Facebook, and Instagram), and volunteered to participate in the research. Data were collected through the Personal Information Form, the "Female Genital Self-Image Scale," the "Golombok-Rust Inventory of Sexual Satisfaction," and the "Female Sexual Distress Scale-Revised." RESULTS: The average age of the participating women was 30.54±5.83 years (n=235). The participants’ mean scores were 18.94±2.92 for the Female Genital Self-Image Scale, 40.07±15.51 for the Golombok-Rust Inventory of Sexual Satisfaction, and 8.85±8.50 for the Female Sexual Distress Scale-Revised total. A statistically significant and negative relationship was found between Female Genital Self-Image Scale and Golombok-Rust Inventory of Sexual Satisfaction and Female Sexual Distress Scale-Revised total scores (r=-0.183, p<0.01; r=-0.387, p<0.01). Regression analysis (forward) was performed, and genital self-image was found to be the predictive factor affecting sexual satisfaction and stress. CONCLUSION: This study found that women had a medium level of genital self-image and sexual satisfaction and a low level of sexual distress. OBJECTIVE Pregnancy childbirth biological psychological womens s health selfimage self image METHODS crosssectional cross sectional 202 program included email, email e mail, mail (e-mail WhatsApp Facebook Instagram, Instagram , Instagram) research Form SelfImage Self Image GolombokRust Golombok Rust ScaleRevised. ScaleRevised Revised. Revised Scale-Revised. RESULTS 3054583 30 54 5 83 30.54±5.8 n=235. n235 n n=235 . 235 (n=235) participants 1894292 18 94 2 92 18.94±2.9 40071551 40 07 15 51 40.07±15.5 885850 8 85 50 8.85±8.5 r=0.183, r0183 r r= 0.183, 0 183 (r=-0.183 p<0.01 p001 p 01 r=0.387, r0387 0.387, 387 r=-0.387 p<0.01. p<0.01) forward (forward performed CONCLUSION distress 20 305458 3 30.54±5. n23 n=23 23 (n=235 189429 9 18.94±2. 4007155 4 40.07±15. 88585 8.85±8. r=0.183 r018 0183 0.183 (r=-0.18 p<0.0 p00 r=0.387 r038 0387 0.387 38 r=-0.38 30545 30.54±5 n2 n=2 (n=23 18942 18.94±2 400715 40.07±15 8858 8.85±8 r=0.18 r01 018 0.18 (r=-0.1 p<0. p0 r=0.38 r03 038 0.38 r=-0.3 3054 30.54± n= (n=2 1894 18.94± 40071 40.07±1 885 8.85± r=0.1 r0 0.1 (r=-0. p<0 r=0.3 03 0.3 r=-0. 305 30.54 (n= 189 18.94 4007 40.07± 88 8.85 r=0. 0. (r=-0 p< r=-0 30.5 (n 18.9 400 40.07 8.8 r=0 (r=- r=- 30. 18. 40.0 8. (r= 40. (r

SUMMARY OBJECTIVE: The aim of this study was to demonstrate the effect of coronavirus disease 2019 on the cardiovascular autonomic system using heart rate variability in young individuals. METHODS: The study was designed retrospectively by scanning the 24-h Holter electrocardiography records of patients who applied to the Ankara Abdurrahman Yurtaslan Oncology Education and Research Hospital Cardiology outpatient clinic. The study group consisted of 492 patients under the age of 40 years, who did not have additional comorbidities or medication use and had prolonged symptoms after coronavirus disease 2019 during the pandemic. The control group, including 401 patients, was determined during the pre-pandemic period (before December 2019). Heart rate variability parameters were evaluated by scanning the 24-h Holter electrocardiography records of the patients and compared with the non-coronavirus disease 2019 group. RESULTS: The median age of participants was 30 years. Standard deviation of normal RR intervals (SDNN) ≤100 ms was more prevalent in the study group (27 (6.7%) vs 73 (14.8%), p<0.001). In univariate logistic regression analysis, the presence of coronavirus disease 2019 [(OR 2.41, 95%CI 1.52–3.83), p<0.001] and age [(OR 1.04, 95%CI 1.01–1.07), p=0.016] had a significant effect on the probability of SDNN≤100. In multivariate logistic regression analysis, the presence of coronavirus disease 2019 [(OR 2.42, 95%CI 1.52–3.85), p<0.001] and age [(OR 2.42, 95%CI 1.52–3.85), p=0.016] had a significant effect on the probability of SDNN≤100. Frequency domain measures such as, high-frequency values were significantly higher in the study group (p=0.029). The study group’s low-frequency/high frequency ratio was significantly lower (p=0.019). The low-frequency/high-frequency ratio’s cut-off value was ≤2.77. for determining the differentiation between coronavirus disease 2019 positive and negative cases in the receiver operating characteristic analysis. The sensitivity rate was 80.7%. The area under the curve value is 0.546 (p=0.019). CONCLUSION: This study showed that coronavirus disease 2019 causes reduced heart rate variability and increased parasympathetic activity in young patients. This may explain the prolonged symptoms after coronavirus disease 2019 infection. OBJECTIVE 201 individuals METHODS 24h h 24 clinic 49 4 years pandemic prepandemic pre before 2019. . 2019) noncoronavirus non RESULTS 3 SDNN (SDNN 100 ≤10 27 (2 6.7% 67 6 7 (6.7% 14.8%, 148 14.8% , 14 8 (14.8%) p<0.001. p0001 p p<0.001 0 001 p<0.001) analysis OR 241 2 41 2.41 95CI CI 95 1.52–3.83, 152383 1.52–3.83 1 52 83 1.52–3.83) 104 04 1.04 1.01–1.07, 101107 1.01–1.07 01 07 1.01–1.07) p=0.016 p0016 016 SDNN100 SDNN≤100 242 42 2.42 1.52–3.85, 152385 1.52–3.85 85 1.52–3.85) as highfrequency high p=0.029. p0029 p=0.029 029 (p=0.029) groups s lowfrequency/high lowfrequencyhigh low frequency/high p=0.019. p0019 p=0.019 019 (p=0.019) lowfrequency/highfrequency lowfrequencyhighfrequency ratios cutoff cut off 277 77 ≤2.77 807 80 80.7% 0546 546 0.54 CONCLUSION infection 20 10 ≤1 ( 6.7 (6.7 14.8 (14.8% p000 p<0.00 00 2.4 9 15238 1.52–3.8 5 1.0 10110 1.01–1.0 p=0.01 p001 SDNN10 SDNN≤10 p002 p=0.02 02 (p=0.029 lowfrequency frequencyhigh (p=0.019 ≤2.7 80.7 054 54 0.5 ≤ 6. (6. 14. (14.8 p00 p<0.0 2. 1523 1.52–3. 1. 1011 1.01–1. p=0.0 SDNN1 SDNN≤1 (p=0.02 (p=0.01 ≤2. 80. 05 0. (6 (14. p0 p<0. 152 1.52–3 101 1.01–1 p=0. SDNN≤ (p=0.0 ≤2 (14 p<0 15 1.52– 1.01– p=0 (p=0. (1 p< 1.52 1.01 p= (p=0 1.5 (p= (p

SUMMARY OBJECTIVE: Falls are a serious cause of morbidity and mortality among older people. One of the underlying causes of falls is dehydration. Therefore, ultrasonography has become an essential tool for evaluating volume status in the emergency department. However, the effect of volume status on falls in older people has not been evaluated before. The aim of this study was to determine the relationship between the inferior vena cava collapsibility index and the injury severity score in older patients who presented with fall-related injuries to the emergency department. METHODS: A total of 66 patients were included in the study. The injury severity score was used as the trauma severity score, and the Edmonton Frail Scale was used as the frailty scale. Volume status was evaluated with inferior vena cava collapsibility index. The primary outcome measure was defined as the correlation between inferior vena cava collapsibility index and injury severity score. Secondary outcome measures were defined as the effect of inferior vena cava collapsibility index and injury severity score on hospitalization and mortality. RESULTS: There was no significant correlation between injury severity score and inferior vena cava collapsibility index (p=0.342). Neither inferior vena cava collapsibility index nor injury severity score was an indicator of the mortality of these patients. However, injury severity score was an indicator of hospitalization. The mean Edmonton Frail Scale score was an indicator of mortality among older people who experienced falls (p=0.002). CONCLUSION: Inferior vena cava collapsibility index cannot be used to predict trauma severity in older patients who have experienced falls admitted to the emergency department. OBJECTIVE dehydration Therefore department However before fallrelated fall related METHODS 6 scale RESULTS p=0.342. p0342 p p=0.342 . 0 342 (p=0.342) p=0.002. p0002 p=0.002 002 (p=0.002) CONCLUSION p034 p=0.34 34 (p=0.342 p000 p=0.00 00 (p=0.002 p03 p=0.3 3 (p=0.34 p00 p=0.0 (p=0.00 p0 p=0. (p=0.3 (p=0.0 p=0 (p=0. p= (p=0 (p= (p

SUMMARY OBJECTIVE: The objective of this study was to investigate serum Metrnl levels in pregnant women with gestational diabetes mellitus and compare them with pregnant women without gestational diabetes mellitus. METHODS: The gestational diabetes mellitus group consisted of 87 pregnant women diagnosed with gestational diabetes mellitus, and the control group consisted of 93 healthy pregnant women without gestational diabetes mellitus. Serum Metrnl levels were determined by the enzyme-linked immunosorbent assay method. RESULTS: The two groups were similar in terms of demographic features. The median serum Metrnl level was found to be 1.16 ng/mL in the gestational diabetes mellitus group, while it was determined as 2.2 ng/mL in the control group (p=0.001). The two groups were divided into two subgroups based on participants’ body mass index, normal weight and overweight. The lowest median Metrnl level was detected in the normal weight gestational diabetes mellitus group, followed by the overweight gestational diabetes mellitus group, normal weight control group, and overweight control group (1.1, 1.2, 2, and 2.4 ng/mL, respectively). Receiver operating curve analysis was performed to determine the value of the serum Metrnl level in terms of predicting gestational diabetes mellitus. The area under the curve analysis of serum Metrnl for gestational diabetes mellitus estimation was 0.768 (p=0.000, 95%CI 0.698–0.839). The optimal cutoff value for serum Metrnl level was determined as 1.53 ng/mL with 69% sensitivity and 70% specificity. CONCLUSION: Serum Metrnl levels in pregnant women with gestational diabetes mellitus were found to be significantly lower than in pregnant women without gestational diabetes mellitus. The mechanisms underlying the decrease in serum Metrnl levels in gestational diabetes mellitus remain unclear for now, and future studies will reveal the role of Metrnl in the pathophysiology of gestational diabetes mellitus. OBJECTIVE METHODS 8 9 enzymelinked enzyme linked method RESULTS features 116 1 16 1.1 ngmL ng mL 22 2 2. p=0.001. p0001 p p=0.001 . 0 001 (p=0.001) participants index 1.1, 11 (1.1 12 1.2 24 4 respectively. respectively respectively) 0768 768 0.76 p=0.000, p0000 000 (p=0.000 95CI CI 95 0.698–0.839. 06980839 0.698–0.839 698 839 0.698–0.839) 153 53 1.5 69 70 specificity CONCLUSION now 1. p000 p=0.00 00 (p=0.001 (1. 076 76 0.7 p=0.000 (p=0.00 0698083 0.698–0.83 83 15 5 6 7 p00 p=0.0 (1 07 0. (p=0.0 069808 0.698–0.8 p0 p=0. ( (p=0. 06980 0.698–0. p=0 (p=0 0698 0.698–0 p= (p= 069 0.698– (p 06 0.698 0.69 0.6

SUMMARY OBJECTIVE: This study was conducted to determine the relationship between bone mineral density, vitamin D level, and sleep quality in female patients with osteoporosis. METHODS: This descriptive correlational study included a total of 318 women diagnosed with osteoporosis. The data were collected using a patient identification form, including items for the plasma vitamin D level and bone mineral density score obtained by the dual-energy X-ray absorptiometry method, and the Pittsburgh Sleep Quality Index. RESULTS: The mean age of the women was 56.49±5.68 years, and their femoral neck T mean score, an indicator of bone mineral density, was −2.94±0.31. Only 6.3% of the women had adequate vitamin D levels. In addition, according to their Pittsburgh Sleep Quality Index scores, 85.8% of the women had poor sleep quality. In the study, no significant difference was found between the women's bone mineral densities and vitamin D levels according to sleep quality (p>0.05). However, there was a weak negative correlation between the duration of osteoporosis, body mass index, and sleep quality (p<0.05). CONCLUSION: There was no association between the vitamin D level, bone mineral density, and sleep quality, but the duration of osteoporosis was negatively associated with sleep quality. Accordingly, it may be recommended to provide education and counseling to postmenopausal women diagnosed with osteoporosis on issues such as sunbathing, vitamin D and calcium preparation intake, weight control, and non-pharmacological treatment approaches by making necessary individual-specific plans to improve sleep quality. OBJECTIVE METHODS 31 form dualenergy dual energy Xray X ray method RESULTS 5649568 56 49 5 68 56.49±5.6 years 294031 2 94 0 −2.94±0.31 63 6 3 6.3 addition scores 858 85 8 85.8 womens s p>0.05. p005 p p>0.05 . 05 (p>0.05) However index p<0.05. p<0.05 (p<0.05) CONCLUSION Accordingly sunbathing intake control nonpharmacological non pharmacological individualspecific individual specific 564956 4 56.49±5. 29403 9 −2.94±0.3 6. 85. p00 p>0.0 (p>0.05 p<0.0 (p<0.05 56495 56.49±5 2940 −2.94±0. p0 p>0. (p>0.0 p<0. (p<0.0 5649 56.49± 294 −2.94±0 p>0 (p>0. p<0 (p<0. 564 56.49 29 −2.94± p> (p>0 p< (p<0 56.4 −2.94 (p> (p< 56. −2.9 (p −2. −2 −

SUMMARY OBJECTIVE: February 2023 saw major earthquakes in Pazarcık and Elbistan, causing significant devastation in Turkey. Patients were transferred to hospitals in neighboring provinces, with multiple traumas—especially fractures and organ injuries—forming the main reasons for hospital admissions. This study aimed to examine earthquake-related injuries in pediatric and adult populations to understand differences. METHODS: This study analyzed 1,220 adults and 590 pediatric patients with radiological imaging out of 8,704 earthquake trauma cases. Radiological images were assessed independently by two radiologists. Statistical analysis using SPSS examined relationships between variables such as age group and injury type. RESULTS: Results showed 40% of adults and 64% of children had normal radiological findings. Cerebral and extremity traumas were most common in pediatrics, while adults showed more extremity, thoracic, and spinal traumas. Significant differences between adult and pediatric groups were observed in cranial fractures, thoracic and lumbar vertebral fractures, hemopneumothorax, lung contusions, rib fractures, femur and talocalcaneal fractures, and compartment syndrome (p<0.001). CONCLUSION: Earthquake-related injuries may vary between children and adults. Due to children's more flexible anatomical structure, it is believed that earthquake-related injuries occur less frequently in children. In this study, head traumas were more common in children compared to adults. The rate of cranial fractures was significantly higher in children, with a higher incidence of epidural hematoma compared to adults. Spinal traumas were more frequent in adults than in children, attributed to children's greater flexibility reducing the risk of entrapment under rubble. Pediatric thoracic compliance being significantly higher than in adults often resulted in milder chest traumas. However, compartment syndrome was more common in children, with a lower rate of accompanying bone fractures compared to adults. No significant difference was observed between children and adults in maxillofacial, abdominal, and pelvic traumas. These findings provide insights for future disaster healthcare planning and management. OBJECTIVE 202 Elbistan Turkey provinces traumasespecially especially injuriesforming forming admissions earthquakerelated related METHODS 1220 1 220 1,22 59 8704 8 704 8,70 cases radiologists type RESULTS 40 64 pediatrics hemopneumothorax contusions p<0.001. p0001 p p<0.001 . 0 001 (p<0.001) CONCLUSION Earthquakerelated Earthquake childrens s structure rubble However maxillofacial abdominal management 20 122 22 1,2 5 870 70 8,7 4 6 p000 p<0.00 00 (p<0.001 2 12 1, 87 7 8, p00 p<0.0 (p<0.00 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

SUMMARY BACKGROUND: Cancer-related fatigue is a pervasive symptom, affecting up to 90% of cancer patients throughout their illness, and can persist well after treatment has ended. Despite its prevalence, no definitive evidence-based treatment exists, leading to an abundance of proposed alternatives, including natural supplements. To further explore the potential effects of guaraná on cancer-related fatigue, a systematic review with meta-analysis was conducted and registered on the International Prospective Register of Systematic Reviews (CRD42023484144). METHODS: A thorough search of PubMed/MEDLINE and Cochrane Library was conducted using MeSH terms and related keywords for cancer-related fatigue and guaraná. Eligible studies were selected according to predetermined criteria and assessed for quality in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Data extraction was independently performed by two reviewers, with any discrepancies resolved by a third researcher. RESULTS: In total, 4 full articles and 1 abstract, encompassing a total of 229 patients from 2009 to 2023, were included in the meta-analysis. Despite high heterogeneity between studies (I2=78%, ꭓ2=18.51, df=4, p=0.0010), the analysis revealed a significant benefit of using guaraná to alleviate cancer-related fatigue, with a standard mean difference of −0.77 (95%CI −1.34, −0.21) and a test for the overall effect of Z=2.68 (p=0.007). CONCLUSION: This meta-analysis provides support for the use of guaraná in the treatment of cancer-related fatigue. However, further investigation through larger prospective randomized controlled trials is necessary to validate these findings. BACKGROUND Cancerrelated Cancer symptom 90 illness ended prevalence evidencebased evidence based exists alternatives supplements cancerrelated metaanalysis meta CRD42023484144. CRD42023484144 CRD . (CRD42023484144) METHODS PubMedMEDLINE PubMed MEDLINE Interventions reviewers researcher RESULTS abstract 22 200 2023 metaanalysis. analysis. I2=78%, I278 I I2 78 (I2=78% ꭓ21851 ꭓ ꭓ2 18 51 ꭓ2=18.51 df4 df df=4 p=0.0010, p00010 p p=0.0010 , 0 0010 p=0.0010) 077 77 −0.7 95%CI 95CI CI 95 134 34 −1.34 −0.21 021 21 Z268 Z 2 68 Z=2.6 p=0.007. p0007 p=0.007 007 (p=0.007) CONCLUSION However findings 9 CRD4202348414 (CRD42023484144 20 202 I2=78% I27 7 (I2=78 ꭓ2185 5 ꭓ2=18.5 df= p0001 p=0.001 001 07 −0. 13 3 −1.3 −0.2 02 Z26 6 Z=2. p000 p=0.00 00 (p=0.007 CRD420234841 (CRD4202348414 I2=78 (I2=7 ꭓ218 ꭓ2=18. −0 −1. Z2 Z=2 p00 p=0.0 (p=0.00 CRD42023484 (CRD420234841 I2=7 (I2= ꭓ21 ꭓ2=18 − −1 Z= p0 p=0. (p=0.0 CRD4202348 (CRD42023484 I2= (I2 ꭓ2=1 p=0 (p=0. CRD420234 (CRD4202348 (I ꭓ2= p= (p=0 CRD42023 (CRD420234 (p= CRD4202 (CRD42023 (p CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

SUMMARY OBJECTIVE: Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity. The aim of this study is to investigate the relationship between the VEGF insertion/deletion (I/D) variant (rs35569394) and coronary artery disease susceptibility in the Turkish population. METHODS: A total of 206 subjects, including 106 coronary artery disease patients and 100 controls, were included in this study. The VEGF I/D variant was genotyped using the polymerase chain reaction method. RESULTS: The frequency of the I/I, I/D, and D/D genotypes was 35.84 versus 37%, 33.97 versus 36%, and 30.19 versus 27% in patients and the control group, respectively. VEGF I/D genotype and allele distribution were not statistically significant between coronary artery disease patients and controls (p>0.05). There was no significant difference between VEGF I/D genotype distribution and patient characteristics including age, gender, disease duration, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, history of hypertension, history of diabetes mellitus, and smoking (p>0.05). CONCLUSION: This study suggests that the VEGF I/D variant is not a predisposing factor to coronary artery disease disease in a Turkish sample. OBJECTIVE worldwide proliferation permeability thrombogenicity insertiondeletion insertion deletion ID I D (I/D rs35569394 rs (rs35569394 population METHODS 20 subjects 10 method RESULTS II I/I DD 3584 35 84 35.8 37 37% 3397 33 97 33.9 36 36% 3019 30 19 30.1 27 group respectively p>0.05. p005 p p>0.05 . 0 05 (p>0.05) age gender duration highdensity high density cholesterol lowdensity low triglyceride hypertension mellitus CONCLUSION sample rs3556939 (rs3556939 2 1 358 3 8 35. 339 9 33. 301 30. p00 p>0.0 (p>0.05 rs355693 (rs355693 p0 p>0. (p>0.0 rs35569 (rs35569 p>0 (p>0. rs3556 (rs3556 p> (p>0 rs355 (rs355 (p> rs35 (rs35 (p rs3 (rs3 (rs