ABSTRACT Objective: circCPA4 has been defined to be an oncogenic gene. This study examined whether circCPA4 regulates Prostate Cancer (PC) development and revealed its molecular mechanism. Methods: PC tissues and PC cell lines were collected, in which circCPA4/miR-491-5p/SHOC2 levels were evaluated by RT-qPCR and immunoblot. Colony formation assay and EdU assay assessed cell proliferation, flow cytometry measured apoptosis, and Transwell assessed invasion and migration. Ki-67, cleaved caspase-3, E-cadherin, and N-cadherin were evaluated by immunoblot. Based on the luciferase reporter assay and RIP assay the authors investigated the targeting relationship between circCPA4/miR-491-5p/SHOC2. The effect of circCPA4 on tumor growth was evaluated by xenotransplantation in nude mice. Results: circCPA4 and SHOC2 levels were abundant while miR-491-5p expression was low in PC. Loss of circCPA4 decreased the proliferation and EdU-positive rate of PC cells, enhanced apoptosis, and inhibited invasion, migration, and EMT. Upregulation of circCPA4 forced the malignant behaviors of PC cells, and this promotion could be abolished when miR-491-5p was overexpressed or SHOC2 was silenced. CircCAP4 competitively decoyed miR-491-5p mediating SHOC2 expression. circCAP4 suppression inhibited PC tumor growth. Conclusion: circCAP4 acts as a novel oncogenic factor in PC, accelerating the malignant behavior of PC cells via miR-491-5p/SHOC2 interaction. This novel ceRNA axis may be a potential target for PC drug development and targeted therapy in the future. Objective circCPA gene (PC mechanism Methods collected circCPA4/miR4915p/SHOC2 circCPA4miR4915pSHOC2 circCPAmiRpSHOC circCPA4/miR 491 5p/SHOC2 miR 5p p SHOC circCPA4/miR-491-5p/SHOC RTqPCR RT qPCR immunoblot apoptosis migration Ki67, Ki67 Ki 67, 67 Ki-67 caspase3, caspase3 caspase 3, 3 caspase-3 Ecadherin, Ecadherin E cadherin, cadherin E-cadherin Ncadherin N circCPA4/miR4915p/SHOC2. 5p/SHOC2. mice Results miR4915p miRp EdUpositive positive EMT silenced CircCAP circCAP Conclusion miR4915p/SHOC2 miR4915pSHOC2 miRpSHOC miR-491-5p/SHOC interaction future circCPA4/miR4915p/SHOC pSHOC circCPA4miR4915pSHOC circCPA4miR circCPAmiR 49 5pSHOC2 5p/SHOC Ki6 6 Ki-6 caspase- miR4915p/SHOC miR4915pSHOC 4 5pSHOC Ki-

Abstract Objective: This study aimed to develop and internally validate a prediction model for estimating the risk of spontaneous abortion in early pregnancy. Methods: This prospective cohort study included 9,895 pregnant women who received prenatal care at a maternal health facility in China from January 2021 to December 2022. Data on demographics, medical history, lifestyle factors, and mental health were collected. A multivariable logistic regression analysis was performed to develop the prediction model with spontaneous abortion as the outcome. The model was internally validated using bootstrapping techniques, and its discrimination and calibration were assessed. Results: The spontaneous abortion rate was 5.95% (589/9,895) 1. The final prediction model included nine variables: maternal age, history of embryonic arrest, thyroid dysfunction, polycystic ovary syndrome, assisted reproduction, exposure to pollution, recent home renovation, depression score, and stress score 1. The model showed good discrimination with a C-statistic of 0.88 (95% CI 0.87‒0.90) 1, and its calibration was adequate based on the Hosmer-Lemeshow test (p = 0.27). Conclusions: The prediction model demonstrated good performance in estimating spontaneous abortion risk in early pregnancy based on demographic, clinical, and psychosocial factors. Further external validation is recommended before clinical application. Objective Methods 9895 9 895 9,89 202 2022 demographics factors collected outcome techniques assessed Results 595 5 95 5.95 589/9,895 5899895 589 (589/9,895 1 variables age arrest dysfunction syndrome reproduction pollution renovation Cstatistic C statistic 088 0 88 0.8 95% (95 0.87‒0.90 087090 87 90 HosmerLemeshow Hosmer Lemeshow p 0.27. 027 0.27 . 27 0.27) Conclusions demographic application 989 89 9,8 20 59 5.9 589/9,89 589989 58 (589/9,89 08 8 0. (9 0.87‒0.9 08709 02 0.2 2 98 9, 5. 589/9,8 58998 (589/9,8 ( 0.87‒0. 0870 589/9, 5899 (589/9, 0.87‒0 087 589/9 (589/9 0.87‒ 589/ (589/ 0.87 (589 (58 (5

Abstract Objectives: This experimental study focused on the intra- and inter-rater reproducibility of vertical bone level (VBL) measurements at strategic mini-implants (MI) using digital panoramic radiographs (PR). Study design: VBLs of 152 MIs for removable partial denture stabilization at 50 randomly chosen PRs from a clinical trial were digitally evaluated by three ratters. Rater deviations exceeding 0.5 mm were re-examined. The intra-class correlation coefficient (ICC) was applied to estimate reliability. The smallest detectable change (SDC) was interrelated to the minimal clinically important change of 0.2 mm. Results: The first measurement round revealed intra- and inter-rater ICCs of > 0.8. However, 28 sites (9 %) were unreadable, and 97 sites (32 %) revealed differences between observers of ≥ 0.5 mm. Following a consensus session and re-training, an additional 8 sites were excluded and all remaining VBL differences were ≤ 0.5 mm. Thus, the SDCs with 95 % credibility were improved from 0.73 to 0.31 mm in the intra-rater and from 1.52 to 0.34 mm in the interrater statistics. Given a 50 % credibility for this special setting, both the intra- and inter-rater SDCs were 0.11 mm. Conclusions: Digital PR can be reliably utilized to determine VBLs around MIs under conditions of at least two trained observers, mutual calibration sessions, and exclusion of unquantifiable radiographs. German Clinical Trials Register ID:DRKS00007589, www.germanctr.de Objectives intra inter rater (VBL miniimplants mini implants MI (MI PR. . (PR) design 15 5 ratters 05 0 0. reexamined. reexamined re examined. examined re-examined intraclass class ICC (ICC reliability SDC (SDC 02 2 Results 08 0.8 However 9 ( unreadable 32 (3 retraining, retraining training, training re-training Thus 073 73 0.7 031 31 0.3 intrarater 1 52 1.5 034 34 statistics setting 011 11 0.1 Conclusions sessions IDDRKS00007589, IDDRKS00007589 IDDRKS ID DRKS00007589, DRKS00007589 DRKS ID:DRKS00007589 wwwgermanctrde www germanctr de (PR 3 07 7 03 1. 01 IDDRKS0000758 DRKS0000758 ID:DRKS0000758 IDDRKS000075 DRKS000075 ID:DRKS000075 IDDRKS00007 DRKS00007 ID:DRKS00007 IDDRKS0000 DRKS0000 ID:DRKS0000 IDDRKS000 DRKS000 ID:DRKS000 IDDRKS00 DRKS00 ID:DRKS00 IDDRKS0 DRKS0 ID:DRKS0 ID:DRKS

Abstract Objective: This study aimed to systematically evaluate the efficacy and safety of Endoscopic Ultrasonography (EUS) for the treatment of pancreatic cancer. Methods: The PubMed, Embase, Web of Science, and Google Scholar databases were searched from the inception of the databases to June 2022. RevMan 5.3.0 software was utilized for data analysis. In total, 13 self-descriptive studies, which enrolled 382 patients, were finally included. Results It was revealed that EUS for the treatment of pancreatic cancer exhibited a lower incidence of adverse reactions (Relative Risk Ration [RR = 0.23], 95 % Confidence interval [95 % CI 0.23-0.23]), a higher success rate (RR = 0.90, 95 % CI 0.90-0.90), and a low failure rate (RR = 0.06, 95 % CI 0.06-0.06). Moreover, EUS-guided Celiac Plexus Neurolysis (EUS-CPN) not only significantly relieved pancreatic cancer patients’ pain (RR = 0.83, 95 % CI 0.83-0.83), but also significantly eliminated pain in some patients (RR = 0.09, 95 % CI 0.09-0.09). The effects of EUS on pancreatic cancer treatment were satisfactory, and few adverse reactions were found. Conclusion: Owing to the restricted sample size in this meta-analysis, primarily consisting of descriptive studies, it was imperative to conduct more rigorously designed, multi-center, long-term follow-up, larger sample, and Randomized Controlled Trials (RCTs) to validate the findings. Objective (EUS Methods PubMed Embase Science 2022 530 5 3 0 5.3. analysis total 1 selfdescriptive self studies 38 included Relative RR 0.23, 023 0.23 , 23 0.23] 9 [9 0.230.23, 023023 0.23-0.23]) 090 90 0.90 0.900.90, 090090 0.90-0.90) 006 06 0.06 0.060.06. 006006 . 0.06-0.06) Moreover EUSguided guided EUSCPN CPN (EUS-CPN 083 83 0.83 0.830.83, 083083 0.83-0.83) 009 09 0.09 0.090.09. 009009 0.09-0.09) satisfactory found Conclusion metaanalysis, metaanalysis meta analysis, meta-analysis designed multicenter, multicenter multi center, center multi-center longterm long term followup, followup follow up, up follow-up RCTs (RCTs findings 202 53 5.3 02 0.2 2 [ 230 0.230.23 02302 0.23-0.23] 0.9 900 0.900.90 09009 0.90-0.90 00 0.0 060 0.060.06 00600 0.06-0.06 08 8 0.8 830 0.830.83 08308 0.83-0.83 0.090.09 00900 0.09-0.09 20 5. 0. 0.230.2 0230 0.23-0.23 0.900.9 0900 0.90-0.9 0.060.0 0060 0.06-0.0 0.830.8 0830 0.83-0.8 0.090.0 0090 0.09-0.0 0.230. 0.23-0.2 0.900. 0.90-0. 0.060. 0.06-0. 0.830. 0.83-0. 0.090. 0.09-0. 0.230 0.23-0. 0.900 0.90-0 0.060 0.06-0 0.830 0.83-0 0.090 0.09-0 0.23-0 0.90- 0.06- 0.83- 0.09- 0.23-

Abstract This controlled study investigated metabolic changes in non-vaccinated individuals with Long-COVID-19, along with their connection to the severity of the disease. The study involved 88 patients who experienced varying levels of initial disease severity (mild, moderate, and severe), and a control group of 29 healthy individuals. Metabolic risk markers from fasting blood samples were analyzed, and data regarding disease severity indicators were collected. Findings indicated significant metabolic shifts in severe Long-COVID-19 cases, mainly a marked drop in HDL-C levels and a doubled increase in ferritin levels and insulin resistance compared to the mild cases and controls. HDL-C and ferritin were identified as the leading factors predicted by disease severity. In conclusion, the decline in HDL-C levels and rise in ferritin levels seen in Long-COVID-19 individuals, largely influenced by the severity of the initial infection, could potentially play a role in the persistence and progression of Long-COVID-19. Hence, these markers could be considered as possible therapeutic targets, and help shape preventive strategies to reduce the long-term impacts of the disease. nonvaccinated non vaccinated LongCOVID19, LongCOVID19 LongCOVID Long COVID 19, 19 8 mild, (mild moderate severe, , severe) 2 analyzed collected Long-COVID-1 HDLC HDL C controls conclusion infection LongCOVID19. 19. Hence targets longterm long term LongCOVID1 1 Long-COVID- Long-COVID

Abstract Objective: This study aims to correlate the RAPID score with the 3-month survival and surgical results of patients undergoing lung decortication with stage III pleural empyema. Methods: This was a retrospective study with the population of patients with pleural empyema who underwent pulmonary decortication between January 2019 and June 2022. Data were collected from the institution’s database, and patients were classified as low, medium, and high risk according to the RAPID score. The primary outcome was 3-month mortality. Secondary outcomes were the length of hospital stay, readmission rate, and the need for pleural re-intervention. Results: Of the 34 patients with pleural empyema, according to the RAPID score, patients were stratified into low risk (23.5 %), medium risk (47.1 %), and high risk (29.4 %). The high-risk group had a 3-month mortality of 40 %, while the moderate-risk group hada 6.25 % and the low-risk group had no deaths within 90days, confirmingagood correlation with the RAPID score (p < 0.05). Sensitivity and specificity for the primary outcome in the high-risk score were 80.0 % and 79.3%, respectively. The secondary outcomes did not reach statistical significance. Conclusions: In this retrospective series, the RAPID score had a good correlation with 3-month mortality in patients undergoing lung decortication. The morbidity indicators did not reach statistical significance. The present data justifies further studies to explore the capacity of the RAPID score to be used as a selection tool for treatment modality in patients with stage III pleural empyema. Objective 3month month 3 Methods 201 2022 institutions institution s database stay rate reintervention. reintervention re intervention. intervention re-intervention Results 23.5 235 23 5 (23. , %) 47.1 471 47 1 (47. 29.4 294 29 4 (29. %. . highrisk moderaterisk moderate 625 6 25 6.2 lowrisk 90days days p 0.05. 005 0.05 0 05 0.05) 800 80 80. 793 79 79.3% respectively significance Conclusions series 20 202 23. 2 (23 47. (47 29. (29 62 6. 00 0.0 8 7 79.3 (2 (4 0. 79. (

Abstract Objectives Atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall, in which Human Vascular Smooth Muscle Cells (HVSMCs) are involved. Nevertheless, the functions and mechanisms of circRNAs in oxidized Low-Density Lipoprotein (ox-LDL)-induced vascular smooth muscle cells remain unclear. Methods Circ-ABCA1 expression was measured in the models of AS. Then, in the vitro model, oligonucleotide transfection was performed, followed by an analysis of VSMC proliferation, migration, inflammation, and phenotypic switch. Also, in the in vivo model, mice were injected with shRNA lentivirus, followed by histological examination of aortic tissues. Finally, the interaction of circ-ABCA1, miR-885–5p, and ROCK2 was identified. Results Circ-ABCA1, was confirmed to be overexpressed in ox-LDL-induced VSMCs and mouse models of AS. Functionally, silencing circ-ABCA1 via oligonucleotide transfection suppressed VSMC proliferation, migration, inflammation, and phenotypic switch in vitro and prevented AS development in mice in vivo. Mechanistically, circ-ABCA1 absorbed miR-885–5p, which targeted ROCK2. Conclusion Taken together, the data from this study suggest that circ-ABCA1 mediates cellular inflammation and phenotype switching through the miR-885–5p/ROCK2 axis in ox-LDL-induced VSMCs, and the circ-ABCA1/miR-885–5p/ROCK2 axis is a new potential biomarker for the treatment of AS. (AS wall HVSMCs (HVSMCs involved Nevertheless LowDensity Low Density oxLDLinduced ox LDL induced unclear CircABCA1 CircABCA Circ ABCA1 ABCA Circ-ABCA Then model performed proliferation migration Also lentivirus tissues Finally circABCA1, circABCA1 circABCA circ ABCA1, miR885–5p, miR8855p miRp miR 885–5p, 885 5p p miR-885–5p ROCK identified CircABCA1, Functionally circ-ABCA Mechanistically together miR885–5p/ROCK2 miR8855pROCK2 miRpROCK 885–5p/ROCK2 miR-885–5p/ROCK circABCA1/miR885–5p/ROCK2 circABCA1miR8855pROCK2 circABCAmiRpROCK ABCA1/miR circ-ABCA1/miR-885–5p/ROCK miR885 miR885–5p 8855p 885–5p 88 miR885–5p/ROCK pROCK miR8855pROCK 8855pROCK2 885–5p/ROCK circABCA1/miR885–5p/ROCK circABCA1miR8855pROCK ABCA1miR ABCAmiR miR88 8 8855pROCK miR8

Abstract Background: The antiemetic effectiveness of olanzapine, as a prophylactic off-label antiemetic drug, for Postoperative Nausea and Vomiting (PONV) is unknown. In this systematic review and meta-analysis, the authors evaluate the efficacy and side effects of olanzapine as a prophylactic antiemetic in adult patients who undergo general anesthesia and assess adverse effects. Methods: A systematic search was done on electronic bibliographic databases in July 2023. Randomized controlled trials of olanzapine as a prophylactic antiemetic for PONV in adults who underwent general anesthesia were included. The authors excluded non-RCTs and retracted studies. The authors set no date of publication or language limits. The outcomes were the incidence of PONV within 24 h postoperatively and the safety of olanzapine. The risk of bias was assessed according to the tool suggested by the National Heart, Lung, and Blood Institute. Results: Meta-analysis included 446 adult patients. Olanzapine reduced on average 38 % the incidence of PONV. The estimated risk ratio (95 % CI) of olanzapine versus control was 0.62 (0.42-0.90), p = 0.010, I2 = 67 %. In the subgroup meta-analysis, doses of olanzapine (10 mg) reduced on average 49 % of the incidence of PONV (RR = 0.51 [0.34-0.77], p = 0.001, I2 = 31 %). Conclusion: This systematic review with meta-analysis indicated that olanzapine as a prophylactic antiemetic alone or combined with other antiemetic agents reduced the incidence of postoperative nausea and vomiting. However, this conclusion must be presented with some degree of uncertainty due to the small number of studies included. There was a lack of any evidence to draw conclusions on side effects. Background offlabel off label drug (PONV unknown metaanalysis, metaanalysis meta analysis, analysis Methods 2023 nonRCTs non RCTs limits 2 Heart Lung Institute Results Metaanalysis Meta 44 3 95 (9 CI 062 0 62 0.6 0.420.90, 042090 0.42 0.90 , 42 90 (0.42-0.90) 0010 010 0.010 I 6 10 (1 mg 4 RR 051 51 0.5 0.340.77, 034077 0.34 0.77 34 77 [0.34-0.77] 0001 001 0.001 . %) Conclusion vomiting However 202 9 ( 06 0. 420 0.420.90 04209 042 0.4 090 0.9 (0.42-0.90 01 0.01 1 05 5 340 0.340.77 03407 034 0.3 077 0.7 7 [0.34-0.77 000 00 0.00 20 0.420.9 0420 04 09 (0.42-0.9 0.0 0.340.7 0340 03 07 [0.34-0.7 0.420. (0.42-0. 0.340. [0.34-0. 0.420 (0.42-0 0.340 [0.34-0 (0.42- [0.34- (0.42 [0.34 (0.4 [0.3 (0. [0. (0 [0 [

Abstract Background and objective: Lower limb varicose veins are a prevalent disease associated with several available treatment options, including conventional surgery and polidocanol foam sclerotherapy. However, few studies have analyzed therapeutic modality outcomes based on Patient-Reported Outcome Measures (PROMs). This large sample-size study was designed to evaluate the outcomes of polidocanol foam sclerotherapy compared to conventional surgery based on an analysis of PROMs. Methods: This was a prospective, observational, and qualitative study of 205 patients who underwent varicose vein treatment with either polidocanol foam sclerotherapy (57 patients, 90 legs) or conventional surgery (148 patients, 236 legs). Patients were preoperatively assessed and re-evaluated 30 days after the procedure using the Venous Disease Severity Score (VCSS) and specific venous disease quality-of-life questionnaires (VEINES-QoL/Sym). Results: Both treatments significantly improved VCSS and VEINES results 30 days after the procedure (p < 0.05). However, surgery promoted greater improvements in VCSS (on average 4.02-points improvement, p < 0.001), VEINES-QoL (average 8-points improvement, p < 0.001), and VEINES-Sym (average 11.66 points improvement, p < 0.001) than did sclerotherapy. Postoperative pain and aesthetic concerns about the legs were the domains of the questionnaires in which the results varied the most between the treatment modalities, with worse results for sclerotherapy. Conclusion: Both polidocanol foam sclerotherapy and conventional surgery positively impact patients’ quality of life after 30 days, but the improvement is more significant for patients who undergo conventional surgery. objective options However PatientReported Patient Reported PROMs . (PROMs) samplesize sample size Methods prospective observational 20 57 (5 9 148 (14 23 legs. reevaluated re evaluated 3 (VCSS qualityoflife VEINESQoL/Sym. VEINESQoLSym QoL/Sym QoL Sym (VEINES-QoL/Sym) Results 0.05. 005 0.05 0 05 0.05) 4.02points 402points 4.02 4 02 0.001, 0001 0.001 , 001 VEINESQoL 8points 8 VEINESSym 1166 11 66 11.6 modalities Conclusion (PROMs 2 5 ( 14 (1 VEINESQoL/Sym QoLSym (VEINES-QoL/Sym 00 0.0 02points 402 4.0 000 0.00 116 1 6 11. 0. 40 4.

Abstract Introduction: Child health actions in Brazil have their primary focus on early childhood. A new epidemiological profile is emerging for children after the first one thousand days: an increase in non-communicable chronic diseases. This research aimed to analyze the attributes of Primary Health Care comparatively among different age groups, using three years of age as the cutoff point. Methods: The study design was cross-sectional and conducted in three Primary Health Care Units and three Ambulatory Medical Assistance facilities in the Western Region of Sao Paulo. The PCA Tool Brazil was used as the assessment instrument. Results: A total of 311 interviews were conducted with caregivers of children aged 0 to 12 years; 153 children were under three years old, and 158 were three years or older. The attributes that showed statistically significant differences between age groups (< 3 years and > 3 years) were affiliation (4.9 × 3.8), longitudinality (5.7 × 5.2), information system (7.4 × 6.3), and services provided (5.4 × 4.5). Through linear regression analysis, it was observed that there was a trend for better overall and essential scores in the evaluations of the group of children under three years old who attended Primary Health Care Units. Conclusion: The comparative analysis of Primary Health Care attributes among pediatric age groups revealed a trend towards higher scores, according to caregivers’ perceptions, for children under three years old. This study suggests the need for the implementation of programs that can better address the healthcare needs of children beyond early childhood. Introduction childhood days noncommunicable non communicable diseases point Methods crosssectional cross sectional Paulo instrument Results 31 1 15 older < ( 4.9 49 4 9 (4. 3.8, 38 3.8 , 8 3.8) 5.7 57 5 7 (5. 5.2, 52 5.2 2 5.2) 7.4 74 (7. 6.3, 63 6.3 6 6.3) 5.4 54 4.5. 45 4.5 . 4.5) Conclusion perceptions 4. (4 3. 5. (5 7. (7 6.

Abstract Background: This study aimed to identify prognostic factors for pregnancy outcomes and construct a prognostic model for pregnancy outcomes in women with Recurrent Spontaneous Abortions (RSA) treated with cyclosporin A. Methods: A total of 154 RSA patients treated with cyclosporin A between October 2016 and October 2018 were retrospectively recruited. Multivariate logistic regression was applied to identify the prognostic factors for pregnancy success in RSA women treated with cyclosporin A. The Receiver Operating Characteristic (ROC) curve was applied to construct prognostic value, and the prognostic performance was assessed using area under the ROC. Results: After adjusting potential confounding factors, the authors noted increased age (OR = 0.771; 95 % CI 0.693‒0.858; p < 0.001) and positive antinuclear antibodies (OR = 0.204; 95 % CI 0.079‒0.526; p = 0.001) were associated with a reduced incidence of pregnancy success, while positive anti-β2 glycoprotein-I-antibody (OR = 21.941; 95 % CI 1.176‒409.281; p = 0.039) was associated with an increased incidence of pregnancy success after treated with cyclosporin A. The AUC of combining these variables for predicting pregnancy failure was 0.809 (95 % CI 0.735‒0.880). Conclusion: This study systematically identified the prognostic factors for pregnancy success in women treated with cyclosporin A, and the constructed prognostic model based on these factors with relatively higher prognostic value. Further large-scale prospective studies should be performed to validate the prognostic value of the constructed model. Background (RSA Methods 15 201 recruited ROC (ROC Results OR 0.771 0771 0 771 9 0.693‒0.858 06930858 693 858 0.001 0001 001 0.204 0204 204 0.079‒0.526 00790526 079 526 antiβ2 antiβ anti β2 β anti-β glycoproteinIantibody glycoprotein I antibody 21.941 21941 21 941 1.176‒409.281 1176409281 1 176 409 281 0.039 0039 039 0809 809 0.80 (9 0.735‒0.880. 07350880 0.735‒0.880 . 735 880 0.735‒0.880) Conclusion largescale large scale 20 0.77 077 77 0.693‒0.85 0693085 69 85 0.00 000 00 0.20 020 0.079‒0.52 0079052 07 52 21.94 2194 2 94 1.176‒409.28 117640928 17 40 28 0.03 003 03 080 80 0.8 ( 0735088 0.735‒0.88 73 88 0.7 7 0.693‒0.8 069308 6 8 0.0 0.2 02 0.079‒0.5 007905 5 21.9 219 1.176‒409.2 11764092 4 08 0. 073508 0.735‒0.8 0.693‒0. 06930 0.079‒0. 00790 21. 1.176‒409. 1176409 07350 0.735‒0. 0.693‒0 0693 0.079‒0 0079 1.176‒409 117640 0735 0.735‒0 0.693‒ 069 0.079‒ 007 1.176‒40 11764 073 0.735‒ 0.693 06 0.079 1.176‒4 1176 0.735 0.69 0.07 1.176‒ 117 0.73 0.6 1.176 11 1.17 1.1 1.

Abstract Background: The aim of this study was to compare metabolic parameters, plasma Osteopontin (OPN) and Hepatocyte Growth Factor (HGF) levels between Sleeve Gastrectomy (SG) patients in their 6th post-operation month and healthy control patients. Methods: Height, weight, Body Mass Index (BMI) and laboratory parameters of 58 SG patients aged 18‒65 years (Group 1) and 46 healthy control patients (Group 2) were compared. In addition, preoperative and postoperative sixth-month BMI and laboratory parameters of the patients in Group 1 were compared. Results: The mean age and gender distributions of the groups were similar (p > 0.05). Mean BMI was 28.9 kg/m2 in Group 1 and 27 kg/m2 in Group 2 (p < 0.01). While plasma HGF levels were similar between both groups, plasma OPN levels were higher in Group 2 (p < 0.001). Fasting plasma glucose, total cholesterol, triglyceride, fasting plasma insulin and insulin resistance values were higher in Group 1, while alanine aminotransferase and aspartate aminotransferase levels were higher in Group 2 (p < 0.05). There was a strong correlation between plasma HGF and OPN levels in Group 1, but not in Group 2 (Rho = 0.805, p < 0.001). Conclusion: OPN and HGF are promising biomarkers that can be used to better understand and detect problems related to obesity. The fact that patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to non-surgical patients of similar age and gender with higher BMI may be another favorable and previously unknown metabolic effect of SG. Background (OPN (HGF (SG th postoperation post operation Methods Height weight (BMI 5 1865 18 65 18‒6 4 addition sixthmonth sixth Results 0.05. 005 0.05 . 0 05 0.05) 289 28 9 28. kgm2 kgm kg m2 m kg/m 0.01. 001 0.01 01 0.01) 0.001. 0001 0.001 0.001) glucose cholesterol triglyceride Rho 0805 805 0.805 Conclusion obesity postSG nonsurgical non surgical 186 6 18‒ 00 0.0 000 0.00 080 80 0.80 0. 08 8 0.8

Abstract Objective: To evaluate whether the rate of surgical complications is higher during the first semester of the General Surgery residency in the largest hospital complex in Latin America. During this period, students are expected to have less experience in carrying out procedures. Methods: During a period of two years, all General Surgery resident doctors at the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, made a notification of all the procedures they performed (n = 14.063), containing information such as name of the procedure, date, who participated, complications, among others. These data were analyzed with the purpose of evaluating the variation in the rate of complications throughout the year. Results: There was a 52 % increase in the rate of complications in the first academic semester when compared to the second semester. This phenomenon was observed in resident doctors in the first and second years of residency. Furthermore, it was observed that second-year residents remain with high rates of complications, in some procedures, for a longer time than first-year residents. Furthermore, the first three months (March, April and May) seem to have the highest complication rates of the entire year. Conclusion The impact of these complications can affect several health services and the increase in surgical complications in the first half of the year must be monitored by institutions, in order to control this phenomenon. Objective America Methods Paulo n 14.063, 14063 14.063 , 14 063 14.063) procedure date participated others Results 5 Furthermore secondyear firstyear March, March (March May institutions 1406 14.06 1 06 140 14.0 0 14.