Abstract: Cleft lip and palate (CLP) represent the most frequently reported congenital anomaly affecting the craniofacial region. The aim of this study was to assess the output (in number of procedures) of the Brazilian hospitals accredited for the treatment of CLP patients, examine the referral flow of patients requiring this type of care, and ascertain the adequacy of the corresponding infrastructure of these healthcare facilities. Methodologically, the study used an observational, cross-sectional, and ecological design. Output data, categorized by state and macro-region, and patient referral flow records were accessible through the Outpatient Information System (SIA, in its Portuguese acronym) and the Hospital Information System (SIH, in Portuguese), respectively. Infrastructure assessment relied on data sourced from the National Register of Health Establishments (CNES, in Portuguese). Analysis encompassed data from 28 accredited hospitals. Concerning output metrics, the state of São Paulo ranked first in the number of procedures conducted. The establishments exhibiting the lowest output performance comprised six hospitals located in the Southeast region and two in the Center-West region. Examination of patient referral flow corroborated the concentration of procedures predominantly conducted in the Southeast, notably within São Paulo state. Infrastructure evaluation encompassed the following categories: physical facilities, diagnostic and therapeutic support services, equipment, and comprehensive multidisciplinary care services. The data showed that roughly 61% of the hospitals surveyed possessed less than half of the recommended items. The primary deficiency identified pertained to inadequacies in equipment availability. Conversely, the best outcomes were associated with diagnostic and therapeutic support services. It was concluded that enhancing hospital infrastructure is imperative for the amelioration of care provision to patients with CLP across all Brazilian states. Abstract (CLP facilities Methodologically observational crosssectional, crosssectional cross sectional, sectional cross-sectional design macroregion, macroregion macro region, macro-region SIA, SIA (SIA acronym SIH, SIH (SIH Portuguese, , Portuguese) respectively CNES, CNES (CNES Portuguese. . 2 metrics CenterWest Center West categories services 61 items availability Conversely states 6

Abstract: The present study aimed to assess the knowledge, attitudes, and perceptions of dental professionals and students regarding tobacco cessation counseling (TCC) after their participation in a continuing education activity (CEA) entitled "Smoking cessation: How does the dentist participate in this decision?" at the Oral Cancer Seminar: Projeto Maio Vermelho 2021. This study utilized a pre-/post-intervention design, including a pre-intervention questionnaire with 20 close-ended questions, an educational intervention, and a post-intervention questionnaire with nine close-ended questions. Descriptive and statistical analyses were performed using SPSS 25 and GraphPad Prism 8 software. The significance level was set at p = 0.05. A total of 94 participants answered the pre-intervention questionnaire and 52 answered both the pre- and post-intervention questionnaires. Most participants reported regularly asking about smoking status (96.8%), providing advice on tobacco risks (96.8%), and offering some counseling to help patients stop smoking (84.0%). Although participants habitually ask about cigarette use, other forms of tobacco consumption are frequently overlooked. Most participants reported never having attended TCC training during their undergraduate studies (67.0%) or after graduation (71.2%). However, 96.2% showed interest in attending TCC training. The perception that motivational counseling by dentists can encourage patients to stop smoking rose from 87.5 to 98.2% (p<0.05) after the educational intervention. In addition, participants’ self-confidence in conducting TCC increased from 8.9% to 23.3% (p<0.01). The brief CEA on TCC showed favorable outcomes, enhancing the perception of dentists and undergraduate dental students regarding the effectiveness of counseling for smoking cessation and boosting their self-confidence in providing tobacco counseling. Abstract knowledge attitudes (TCC (CEA Smoking decision decision? Seminar 2021 pre/postintervention prepostintervention pre /post intervention post design preintervention 2 closeended close ended questions postintervention software 005 0 05 0.05 9 5 questionnaires 96.8%, 968 96.8% , 96 (96.8%) 84.0%. 840 84.0% . 84 (84.0%) use overlooked 67.0% 670 67 (67.0% 71.2%. 712 71.2% 71 (71.2%) However 962 96.2 875 87 87. 982 98 98.2 p<0.05 p005 (p<0.05 addition selfconfidence self confidence 89 8.9 233 23 3 23.3 p<0.01. p001 p<0.01 01 (p<0.01) outcomes 202 00 0.0 96.8 (96.8% 84.0 (84.0% 67.0 6 (67.0 71.2 7 (71.2% 96. 98. p<0.0 p00 (p<0.0 8. 23. (p<0.01 0. (96.8 84. (84.0 67. (67. 71. (71.2 p<0. p0 (p<0. (96. (84. (67 (71. p<0 (p<0 (96 (84 (6 (71 p< (p< (9 (8 ( (7 (p

Abstract: This study assessed the influence of sociodemographic conditions, oral hygiene habits, and the socio-psychological need for orthodontic treatment on the emotions of caregivers of children with and without autism spectrum disorder (ASD). We conducted a comparative cross-sectional study with families of individuals aged 6 to 14 years at a reference center for neurodevelopmental disorders and two dental school clinics in northeastern Brazil. Caregiver emotions were assessed using the ‘Parental Emotions’ domain of the Family Impact Scale (FIS). We analyzed sociodemographic variables, oral hygiene habits, and sociopsychological need for orthodontic treatment using the esthetic component of the Index of Orthodontic Treatment Need (IOTN). We used descriptive and hierarchical Poisson regression analyses with robust variance (α = 5%). The study included 144 families evenly distributed across the groups. The caregiver group with ASD demonstrated a higher total score for parental emotions (p < 0.001). Factors associated with this factor included caregiver responsible for brushing (PR = 1.34; 95%CI: 1.12–1.59), mandatory need for orthodontic treatment (PR = 1.25; 95%CI: 1.07–1.46), and caregivers’ education up to 8 years (PR = 1.45; 95%CI: 1.02–2.07). Caregivers with lower income showed a lower prevalence of parental emotions (PR = 0.57; 95%CI: 0.35–0.93). Caregivers of children with ASD exhibited a higher emotional burden. Factors associated with parental emotions included responsibility for tooth brushing attributed to caregivers, sociopsychological need for orthodontic treatment, and family income. Abstract conditions habits socio psychological ASD. . (ASD) crosssectional cross sectional 1 Brazil Parental Emotions FIS. FIS (FIS) variables IOTN. IOTN (IOTN) α 5%. 5 5% 5%) groups p 0.001. 0001 0.001 0 001 0.001) PR 1.34 134 34 95%CI 95CI CI 95 1.12–1.59, 112159 1.12–1.59 , 12 59 1.12–1.59) 1.25 125 25 1.07–1.46, 107146 1.07–1.46 07 46 1.07–1.46) 1.45 145 45 1.02–2.07. 102207 1.02–2.07 02 2 1.02–2.07) 0.57 057 57 0.35–0.93. 035093 0.35–0.93 35 93 0.35–0.93) burden (ASD (FIS (IOTN 000 0.00 00 1.3 13 3 9 11215 1.12–1.5 1.2 10714 1.07–1.4 4 1.4 10220 1.02–2.0 0.5 05 03509 0.35–0.9 0.0 1. 1121 1.12–1. 1071 1.07–1. 1022 1.02–2. 0. 0350 0.35–0. 112 1.12–1 107 1.07–1 102 1.02–2 035 0.35–0 11 1.12– 10 1.07– 1.02– 03 0.35– 1.12 1.07 1.02 0.35 1.1 1.0 0.3

Abstract The aim of this study was to evaluate in vivo dental biofilm acidogenicity induced by nine long-term pediatric oral liquid medications (OLMs). A double-blind crossover randomized clinical trial was conducted with 12 individuals aged 18 to 22 years who had good oral hygiene (OSI < 1.1) and a DMFT index of less than 12. Each participant was exposed to nine OLMs and a 10% sucrose solution (positive control) as part of the crossover design. The pH of the dental biofilm was measured with a Beetrode® microelectrode at 0, 5, 10, 15, 20, 25, and 30 min. Statistical analysis was performed to determine the minimum pH and the area under the curve (AUC). One-way ANOVA was utilized, and the significance level was set at 0.05. Pediatric OLMs caused a sucrose-like decrease in biofilm pH, regardless of therapeutic class (p > 0.05). The mean ± standard deviation of the AUC ranged from 16.26 ± 11.59 (cetirizine) to 39.22 ± 20.81 (azithromycin), with no statistically significant difference compared to sucrose (25.22 ± 6.97) (p > 0.05). The findings suggest that pediatric OLMs contribute to dental biofilm acidogenicity, with a more pronounced effect induced by medications used for respiratory diseases and also by antibiotics. longterm long term OLMs. . (OLMs) doubleblind double blind 1 2 OSI 1.1 11 10 positive control design Beetrode 0 5 15 20 25 3 min AUC. (AUC) Oneway One way utilized 005 05 0.05 sucroselike like p 0.05) 1626 16 26 16.2 1159 59 11.5 cetirizine (cetirizine 3922 39 39.2 2081 81 20.8 azithromycin, azithromycin , (azithromycin) 25.22 2522 (25.2 6.97 697 6 97 antibiotics (OLMs 1. (AUC 00 0.0 162 16. 115 11. 392 39. 208 8 20. (azithromycin 25.2 252 (25. 6.9 69 9 0. 25. (25 6. (2 (

Abstract Civil and criminal forensics utilize dental development to estimate age. The method of Nicodemo, Moraes, and Médici Filho (NMM) is a popular dental age estimation tool in South America; however, it lacks a scientific basis for applications in contemporary forensic practice. This research included the largest sample ever collected in Brazil for a similar purpose. The sample consisted of 3,271 panoramic radiographs of female (n = 1,634) and male (n = 1,637) individuals between six and 22.9 years old (mean 14.6 ± 4.9 years). The applied NMM method considered all maxillary and mandibular left permanent teeth (n = 16). The fit between the chronological age and estimated age intervals was assessed, and a correlation test with Lin's correlation coefficient was performed. The overall percentage of fit was 22.5%, without statistically significant differences based on sex (p > 0.05). The percentage of fit was greater in younger individuals, such as those aged 6–6.99 years (90%), and progressively decreased in older individuals, such as those aged 11–11.9 years (18.2%). After 12 years of age, the method could not provide correct classifications up to 25 years of age. Lin's correlation coefficient was predominantly low (ρ = 0.175; 0.367). NMM is considerably limited, and current forensic practice should not apply it to estimate dental age. Nicodemo Moraes (NMM America however purpose 3271 3 271 3,27 n 1,634 1634 1 634 1,637 1637 637 229 22 9 22. mean 146 14 6 14. 49 4 4. years. . years) 16. 16 16) assessed Lins Lin s performed 225 5 22.5% p 0.05. 005 0.05 0 05 0.05) 6699 99 6–6.9 90%, 90 90% , (90%) 11119 11 11–11. 18.2%. 182 18.2% 18 2 (18.2%) ρ 0.175 0175 175 0.367. 0367 0.367 367 0.367) limited 327 27 3,2 1,63 163 63 22.5 00 0.0 669 6–6. (90% 1111 11–11 18.2 (18.2% 0.17 017 17 036 0.36 36 32 3, 1,6 0. 66 6–6 (90 111 11–1 18. (18.2 0.1 01 03 0.3 1, 6– (9 11– (18. ( (18 (1

Abstract This study aimed to evaluate the efficacy of a xenogeneic collagen matrix (XCM) in treating gingival recessions (GR) in a thin gingival phenotype. This double-blind, planned, controlled, split-mouth clinical trial included 30 patients with bilateral recessions, randomly assigned to a test group (extended flap + XCM) and a control group (extended flap + connective tissue graft; CTG). Root coverage at 18 months was 1.75 ± 0.8 mm (72.9%) and 2.4 ± 0.51 mm (88.9%) in the test and the control groups, respectively. The upper limit of the confidence interval was not greater than the non-inferiority margin of 0.69 mm. The increase in gingival thickness was greater for autogenous graft (p = 0.003). Both treatments improved quality of life at 18 months. The keratinized tissue width (KTW) increased significantly in the grafted teeth, in both the test (p < 0.001) and the control groups (p < 0.001). Total root coverage was similar in both groups, reaching 70% and 66.7% in the control and test groups, respectively, with no significant differences observed for partial or complete root coverage (CRC). An association was observed in the quality of the gingival phenotype at 18 months according to the treatment group, i.e., a higher percentage of cases with a thicker phenotype was observed in the control group (86.7%), compared with the test group (53.3%) (p = 0.005). XCM was effective in treating GR, but CTG had better results because of significantly increased gingival thickness and phenotypic conversion. (XCM GR (GR doubleblind, doubleblind double blind, blind double-blind planned controlled splitmouth split mouth 3 extended CTG. . CTG) 1 175 75 1.7 08 0 8 0. 72.9% 729 72 9 (72.9% 24 2 4 2. 051 51 0.5 88.9% 889 88 (88.9% respectively noninferiority non inferiority 069 69 0.6 p 0.003. 0003 0.003 003 0.003) KTW (KTW teeth 0.001 0001 001 0.001. 70 667 66 7 66.7 CRC. CRC (CRC) ie i e i.e. 86.7%, 867 86.7% , 86 (86.7%) 53.3% 533 53 (53.3% 0.005. 0005 0.005 005 0.005) conversion 17 1. 72.9 (72.9 05 5 88.9 (88.9 06 6 000 0.00 00 66. (CRC i.e 86.7 (86.7% 53.3 (53.3 72. (72. 88. (88. 0.0 86. (86.7 53. (53. (72 (88 (86. (53 (7 (8 (86 (5 (

Abstract: The minimally invasive endodontic access is not directly associated with tooth discoloration in the presence of bioceramic or epoxy resin-based root canal sealers. This study aimed to evaluate the influence of minimally invasive access and endodontic sealer composition on the color stability of endodontically-treated teeth, the restorative material adaptation, and the presence of remaining filling material in the pulp chamber. Endodontic access surgery was performed in maxillary central incisors, either through conservative or minimally invasive approaches, and the root was filled with AH Plus or Bio-C Sealer. The crown color was measured with a spectrophotometer at baseline and after root obturation, restoration, and specimen storage for one year in an oven. The occurrence of voids in the restoration and the remaining filling material was analyzed using micro-CT scans. The Yellowness Index (YI) and color changes (∆E00) were calculated after each color measurement. Data of micro-CT were submitted to 2-way ANOVA, and YI and ∆E00 were analyzed with repeated-measures ANOVA. Pair-wise comparisons were performed with Tukey's test (α = 0.05). The experimental conditions had no effect on the presence of the remaining material. The minimally invasive access associated with Bio-C Sealer resulted in more voids between the restoration and the remaining filling material. Only the evaluation time affected YI and ∆E00 values. Specimens became more yellow after filling and storage in the oven (the highest ∆E00 values). The present study showed that sealer and minimally invasive cavities are not associated with crown color stability following endodontic treatment. Abstract resinbased resin based sealers endodonticallytreated endodontically treated teeth adaptation chamber incisors approaches BioC Bio C obturation microCT micro CT scans (YI E00 E (∆E00 measurement 2way way 2 ANOVA ∆E0 repeatedmeasures repeated measures Pairwise Pair wise Tukeys Tukey s α 0.05. 005 0.05 . 0 05 0.05) values values) treatment E0 (∆E0 ∆E 00 0.0 (∆E 0.

Abstract The aim of this randomized clinical study was to assess the comparative efficacy of flurbiprofen in tablet and spray formulations for postoperative pain management in oral soft tissue wounds undergoing primary closure while investigating the feasibility of achieving optimal analgesia with reduced dosage and risk. Forty patients who underwent epulis fissuratum and frenulum excision for pre-prosthetic surgery were randomly assigned to receive either tablet or spray forms of flurbiprofen. The lesion dimensions were measured preoperatively, followed by excision and primary closure. The tablet group received oral tablets containing 100 mg of flurbiprofen twice daily, whereas the spray group received an oral spray containing 0.25% flurbiprofen, administered as two sprays thrice daily. Postoperative pain was assessed using the Numerical Rating Scale (NRS) until the 7th day. Lesion size, drug consumption, and rescue analgesic use were compared between the groups. There were no statistically significant differences in the lesion size between the groups. However, the mean NRS score in the spray group was significantly lower in the spray group compared to than that in the tablet group at 6th hour postoperatively (p = 0.037). Significant differences favoring the tablet group were observed in the first three doses of the drug (p = 0.001). No patients required rescue analgesics. The spray formulation of flurbiprofen demonstrated effective and safe pain relief in oral soft tissue wounds undergoing primary closure, with no reported adverse effects. risk preprosthetic pre prosthetic preoperatively 10 daily 025 0 25 0.25 (NRS th day consumption groups However p 0.037. 0037 0.037 . 037 0.037) 0.001. 0001 0.001 001 0.001) analgesics effects 1 02 2 0.2 003 0.03 03 000 0.00 00 0. 0.0

Abstract: This cross-sectional observational study aimed to evaluate and compare facial metrics in women aged 20–65 years using a three-dimensional (3D) stereophotogrammetry system and to establish standardized values for facial metric variations in different age subgroups. This study included 84 Caucasian women divided into two groups based on their age: group 1 (G1) included women aged 20–40 years and group 2 (G2) included women aged 41–65 years. Twenty-one morphometric points on the face were identified, and the facial images were captured using a 3D stereophotogrammetry system, Twenty-three linear measures and 12 angular measures were evaluated, revealing statistically significant differences in 11 linear and 5 angular measures between the groups. In the G2 group, nasal and mouth width, lip philtrum height, Tragus-Nasion and Tragus-Pronasale lengths were increased, along with increased nasofrontal angle, decreased palpebral fissure inclination, and lip vermilion angles. However, palpebral fissure width and height, binocular width, and lip vermilion height were reduced. The aging process in women causes substantial changes in facial features, particularly in the middle and lower thirds of the face. Conversely, no major changes were observed in the upper third of the face. Our study findings provide potential insights for clinicians in developing facial rejuvenation procedures as well as for forensic purposes and surgical planning. The standardized facial metrics values in different age subgroups can guide clinicians in determining appropriate treatment plans for patients seeking facial rejuvenation. Abstract crosssectional cross sectional 2065 20 65 20–6 threedimensional three dimensional D (3D 8 G1 G (G1 2040 40 20–4 (G2 4165 41 41–6 Twentyone Twenty one identified Twentythree evaluated TragusNasion Tragus Nasion TragusPronasale Pronasale angle inclination angles However reduced features Conversely planning 206 6 20– (G 204 4 416 41–