Objective: To investigate the trajectory of positive attributes from childhood to early adulthood and how these trajectories might be modified by environmental factors. Methods: We enrolled 2,511 participants aged 6 to 14 years from a large prospective school-based community cohort of Brazilian children and adolescents, 45% of whom were girls. They were assessed and followed for up to 3 years (with 80% retention) or 6 years (with 71% retention). Positive attributes were assessed by using the Youth Strength Inventory (YSI). A composite measure using several indicators was used to assess childhood exposure to threats and deprivations. Results: The trajectories of YSI scores were nonlinear for male and female participants, being high in childhood, decreasing in adolescence, and being high again in early adulthood. Exposure to threat and deprivation presented a negative linear association with YSI over time. Furthermore, exposure to threat and deprivation early in life, but not later, presented an additional effect on decreasing positive attributes during the life course. Conclusion: Our findings provide new evidence on the trajectories of positive attributes in children and adolescents and show how early life adversity affects not only mental disorders but also positive aspects of mental health. Objective factors Methods 2511 2 511 2,51 1 schoolbased school based 45 girls 80 retention 71 retention. . YSI. (YSI) deprivations Results adolescence time Furthermore later course Conclusion health 251 51 2,5 4 8 7 (YSI 25 5 2,

Objective: The present study combined transcriptomic data and computational techniques based on gene expression signatures to identify new bioactive compounds or Food and Drug Administration-approved drugs for the treatment of bipolar disorder (BD). Methods: Five transcriptomic datasets containing 165 blood samples from individuals with BD were selected from the Gene Expression Omnibus (GEO). The number of participants varied from six to 60, with a mean age between 35 and 48 years and a gender difference between them. Most of these patients were receiving pharmacological treatment. Master regulator analysis (MRA) and gene set enrichment analysis (GSEA) were performed to identify genes that were significantly different between patients with BD and healthy controls and their associations with mood states in patients with BD. In addition, molecules that could reverse the transcriptomic profiles of BD-altered regulons were identified from the Library of Network-Based Cellular Signatures Consortium (LINCS) and the Broad Institute Connectivity Map Drug Repurposing Database (cMap) databases. Results: MRA identified 59 candidate master regulators (MRs) that modulate regulatory units enriched with BD-altered genes. In contrast, GSEA identified 134 enriched genes and 982 regulons whose activation state was determined. Both analyses revealed genes exclusively associated with mania, depression, or euthymia, and some genes were shared among these three mood states. We identified bioactive compounds and licensed drug candidates, including antihypertensives and antineoplastic agents, as promising candidates for the treatment of BD. However, experimental validation is essential to confirm these findings in further studies. Conclusion: Although our data are still preliminary, they provide some insights into the biological patterns of different mood states in patients with BD and their potential therapeutic targets. The strategy of transcriptomics plus bioinformatics offers a way to advance drug discovery and personalized medicine by using gene expression information. Objective Administrationapproved Administration approved . (BD) Methods 16 GEO. GEO (GEO) 60 3 4 them (MRA (GSEA addition BDaltered altered NetworkBased Network Based LINCS (LINCS cMap (cMap databases Results 5 MRs (MRs contrast 13 98 determined mania depression euthymia agents However studies Conclusion preliminary targets information (BD 1 (GEO 6 9

Objective: To compare the prevalence of postpartum depression (PPD) symptoms between high-income countries (HIC) and low- and middle-income countries (LMIC) during the COVID-19 pandemic. Methods: The PubMed, Embase, Virtual Health Library, Scopus, Web of Science, PsycINFO, and CINAHL databases were searched until October 2022 for studies that collected data during the pandemic. The metaprop command was used in the Stata statistical software version 12.0 to run a random-effects meta-analysis. Results: A total of 15 studies with 4,788 postpartum women were included. The overall prevalence of PPD symptoms was 31% (95%CI 21.85-40.99). The pooled prevalence of PPD symptoms among women from HIC (30.5% [95%CI 16.95-46.02]) did not differ significantly from that of women from LMIC (31.5% [95%CI 19.26-45.15]). However, studies that analyzed women up to 1 month after childbirth reported a lower prevalence of PPD symptoms (17.5% [95%CI 9.85-26.62]) compared to those that observed them up to 1 year after childbirth (38.3% [95%CI 33.96-42.83]). Conclusions: The prevalence of PPD symptoms was high across countries, regardless of human development index. This condition must be regularly tracked worldwide to assess, discuss, and recommend more assertive steps that may be implemented to address it based on the particular characteristics of each country. Registration number: PROSPERO CRD42022346861. Objective (PPD highincome income (HIC low middleincome middle (LMIC COVID19 COVID 19 COVID-1 pandemic Methods PubMed Embase Library Scopus Science PsycINFO 202 120 12 0 12. randomeffects random effects metaanalysis. metaanalysis meta analysis. analysis meta-analysis Results 4788 4 788 4,78 included 31 95%CI 95CI CI 95 21.8540.99. 21854099 21.85 40.99 . 21 85 40 99 21.85-40.99) 30.5% 305 30 5 (30.5 16.9546.02 16954602 16.95 46.02 16 46 02 16.95-46.02] 31.5% 315 (31.5 19.2645.15. 19264515 19.26 45.15 26 45 19.26-45.15]) However 17.5% 175 17 (17.5 9.8526.62 9852662 9.85 26.62 9 62 9.85-26.62] 38.3% 383 38 3 (38.3 33.9642.83. 33964283 33.96 42.83 33 96 42 83 33.96-42.83]) Conclusions index assess discuss country number CRD42022346861 CRD COVID1 COVID- 20 478 78 4,7 8540 21.8540.99 2185409 2185 21.8 4099 40.9 2 8 21.85-40.99 30.5 (30. 9546 16.9546.0 1695460 1695 16.9 4602 46.0 16.95-46.02 31.5 (31. 2645 19.2645.15 1926451 1926 19.2 4515 45.1 19.26-45.15] 17.5 (17. 8526 9.8526.6 985266 985 9.8 2662 26.6 6 9.85-26.62 38.3 (38. 9642 33.9642.83 3396428 3396 33.9 4283 42.8 33.96-42.83] CRD4202234686 47 7 4, 854 21.8540.9 218540 218 21. 409 40. 21.85-40.9 30. (30 954 16.9546. 169546 169 16. 460 46. 16.95-46.0 31. (31 264 19.2645.1 192645 192 19. 451 45. 19.26-45.15 17. (17 852 9.8526. 98526 98 9. 266 26. 9.85-26.6 38. (38 964 33.9642.8 339642 339 33. 428 42. 33.96-42.83 CRD420223468 21.8540. 21854 21.85-40. (3 16.9546 16954 16.95-46. 19.2645. 19264 19.26-45.1 (1 9.8526 9852 9.85-26. 33.9642. 33964 33.96-42.8 CRD42022346 21.8540 21.85-40 ( 16.954 16.95-46 19.2645 19.26-45. 9.852 9.85-26 33.9642 33.96-42. CRD4202234 21.854 21.85-4 16.95-4 19.264 19.26-45 9.85-2 33.964 33.96-42 CRD420223 21.85- 16.95- 19.26-4 9.85- 33.96-4 CRD42022 19.26- 33.96- CRD4202 CRD420 CRD42 CRD4

Objective: To evaluate the effectiveness of online group cognitive behavioral therapy (CBT) based on the CAMALEO TOC manual in the treatment of adolescents with obsessive-compulsive disorder (OCD). Methods: This is a quasi-experimental study with a single-group pretest-posttest intervention. Over a 12-week period, 11 adolescents aged 11 to 17 years with OCD participated in weekly online group CBT sessions based on the CAMALEO TOC manual. We used several assessment tools, including the Children’s Yale-Brown Obsessive-Compulsive Scale to assess the severity of OCD symptoms, the Family Accommodation Scale for Obsessive-Compulsive Disorder-Interviewer-Rated to measure family accommodation, the Children’s Depression Inventory to assess depression symptoms, the Revised Children’s Manifest Anxiety Scale to assess anxiety, and the Multidimensional Students’ Life Satisfaction Scale to measure satisfaction with life. Results: OCD symptoms decreased significantly (d = -1.55) after online group CBT, and a strong effect size (d = -1.03) was found for family accommodation. After controlling for variables (e.g., engagement in psychotherapeutic treatment, medication use, or psychiatric comorbidities), no significant differences were found for OCD symptoms and family accommodation scores. In addition, there was insufficient evidence to support the effectiveness of online group CBT in reducing symptoms of depression or anxiety or improving overall quality of life. Conclusion: Our study demonstrates the feasibility of short-term online group CBT as an effective therapeutic approach for adolescents with OCD. Objective (CBT obsessivecompulsive obsessive compulsive . (OCD) Methods quasiexperimental quasi experimental singlegroup single pretestposttest pretest posttest intervention 12week week 12 period 1 tools Childrens Children s YaleBrown Yale Brown ObsessiveCompulsive Obsessive Compulsive DisorderInterviewerRated Disorder Interviewer Rated Students life Results d 1.55 155 55 -1.55 1.03 103 03 -1.03 e.g., eg e g (e.g. use comorbidities, comorbidities , comorbidities) scores addition Conclusion shortterm short term (OCD 1.5 15 5 -1.5 1.0 10 0 -1.0 e.g. (e.g 1. -1. e.g -1 -

Objective: To conduct a thorough examination of the current understanding of the effect of maternal depression exposure on the executive functions (EFs) of offspring. Methods: Following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statement, a comprehensive search for peer-reviewed cohort studies was performed on the MEDLINE (via PubMed), ScienceDirect, LILACS, PsycINFO, and SciELO databases. Study quality was assessed using the National Heart, Lung, and Blood Institute (NHLBI) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The evidence was evaluated using the Grading of Recommendation, Assessment, Development, and Evaluation framework. Results: Thirty-three cohort studies from different countries, enrolling a total of 38,981 participants, were analyzed. Twenty-four studies confirmed the hypothesis of a harmful effect of maternal depressive symptoms on offspring EF. However, high heterogeneity among studies was found, and meta-analysis was not feasible. Fetal programming, genetics, and parental practices have been identified as potential mechanisms that can affect the EFs of children born to mothers who have experienced depressive symptoms. Conclusion: Our findings suggest a negative association between maternal depressive symptoms and offspring EF. Further studies on the effects of chronicity/severity of maternal symptoms and changes in EFs in different sensitive periods are needed. Registration number: PROSPERO CRD42020221193. Objective (EFs Methods Metaanalyses Meta analyses PRISMA (PRISMA statement peerreviewed peer reviewed via PubMed, PubMed , PubMed) ScienceDirect LILACS PsycINFO databases Heart Lung NHLBI (NHLBI CrossSectional Cross Sectional Studies Recommendation Development framework Results Thirtythree Thirty three countries 38981 38 981 38,98 participants analyzed Twentyfour Twenty four EF However found metaanalysis meta analysis feasible programming genetics Conclusion chronicityseverity chronicity severity needed number CRD42020221193 CRD 3898 3 98 38,9 CRD4202022119 389 9 38, CRD420202211 CRD42020221 CRD4202022 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4

Objective: To test the factor structure, reliability, and validity of the Brazilian version of the Abbreviated Suicidal Narrative Inventory (SNI-38). Methods: We used an anonymous online questionnaire of the SNI-38 and self-report measures administered between November 2020 and October 2021 in the Brazilian community. Participants were recruited through social media advertisements. Confirmatory factor analysis (CFA) was performed to test the factor structure of the SNI-38. In addition, we assessed internal consistency and convergent validity against stressful life events, suicide crisis syndrome, suicidal ideation, and suicide attempts. Results: A total of 2,660 participants were included. The eight-factor model of the SNI-38 had a good model fit (χ2[637] = 7,473.98, p < 0.001, comparative fit index [CFI] = 0.99, Tucker-Lewis index [TLI] = 0.99, root mean squared error of approximation [RMSEA] = 0.07, standardized root mean residual [SRMR] = 0.06). Notably, all items were significantly and positively loaded onto their respective factors (factor loadings ≥ 0.45). The reliability of all subscales except for goal disengagement ranged from good to high. Furthermore, all subscales except goal disengagement showed positive correlations with variables such as suicide crisis syndrome, stressful life events, lifetime/past month suicidal ideation, and lifetime suicide attempts. Conclusion: These findings provide preliminary support for the validity of the Brazilian version of the SNI-38 as an appropriate, valid instrument for measuring suicidal narratives in Brazilian individuals. Objective SNI38. SNI38 SNI 38 . (SNI-38) Methods SNI-3 selfreport self report 202 community advertisements CFA (CFA 38. addition events syndrome ideation attempts Results 2660 2 660 2,66 included eightfactor eight χ2637 χ χ2 637 (χ2[637 747398 7 473 98 7,473.98 0001 0 001 0.001 CFI [CFI 099 99 0.99 TuckerLewis Tucker Lewis TLI [TLI RMSEA [RMSEA 007 07 0.07 SRMR [SRMR 0.06. 006 0.06 06 0.06) Notably 0.45. 045 0.45 45 0.45) high Furthermore lifetimepast past Conclusion appropriate individuals SNI3 3 (SNI-38 SNI- 20 266 66 2,6 χ263 63 (χ2[63 74739 47 9 7,473.9 000 00 0.00 09 0.9 0.0 04 0.4 4 (SNI-3 26 6 2, χ26 (χ2[6 7473 7,473. 0. (SNI- (χ2[ 747 7,473 (SNI (χ2 74 7,47 (χ 7,4 7,

Objective: The risk of suicide is higher among health care workers than other workers. This study investigated the association between social support and suicidal ideation and behavior during the COVID-19 pandemic among Brazilian health care workers. Methods: This study used data from 10,885 respondents to the first (time point 1 – between May and June of 2020) and second (time point 2 – between December 2020 and February 2021) cross-sectional online surveys about mental health and quality of life among Brazilian health care workers during the COVID-19 pandemic. The relationship between social support as the independent variable (time point 1) and suicidal ideation and behavior as the outcomes (time point 2) was investigated through logistic regression analysis. Results: Greater social support was associated with a significantly lower risk of reporting suicidal ideation and behavior in the month prior to follow-up assessment (adjusted OR: 0.71, 95%CI 0.66-0.76 and adjusted OR 0.61, 95%CI 0.54-0.68, respectively). These associations were independent of sex, age, feelings of loneliness, and self-reported psychiatric disorders. Conclusion: Social support is associated with a lower risk of suicidality among health care workers, and its protective role appears more closely related to suicidal behavior. Objective COVID19 COVID 19 COVID-1 Methods 10885 10 885 10,88 time 202 2021 crosssectional cross sectional analysis Results followup follow up 071 0 71 0.71 95CI CI 95 0.660.76 066076 0.66 0.76 66 76 0.66-0.7 061 61 0.61 0.540.68, 054068 0.54 0.68, 54 68 0.54-0.68 respectively. respectively . respectively) sex age loneliness selfreported self reported disorders Conclusion COVID1 COVID- 1088 88 10,8 20 07 7 0.7 9 660 0.660.7 06607 066 0.6 076 6 0.66-0. 06 540 0.540.68 05406 054 0.5 068 0.68 5 0.54-0.6 108 8 10, 0. 0.660. 0660 0.66-0 0.540.6 0540 05 0.54-0. 0.660 0.66- 0.540. 0.54-0 0.540 0.54-

Objective: From a preventive perspective, this study reviewed the literature on protective factors against depressive symptoms in high-risk children and adolescents. Methods: We conducted a thorough search of the PubMed, APA, EMCare, and Embase databases for studies published between 1946 and August 25, 2023. We included only longitudinal studies that analyzed protective factors for depressive symptoms in high-risk children or adolescents, excluding cross-sectional studies, reviews, and pre-clinical studies. Results: A total of 29 studies with 62,405 participants were analyzed and 38 protective factors were identified. Positive individual characteristics, family factors, peer relationships, school-related aspects, neighborhood characteristics, and intrinsic religiosity were associated with improved depression outcomes. Conclusion: These findings have important implications for preventive strategies in this population. Addressing protective factors can help prevent depression and enhance lifetime mental health. Objective perspective highrisk high risk adolescents Methods PubMed APA EMCare 194 25 2023 crosssectional cross sectional reviews preclinical pre clinical Results 2 62405 62 405 62,40 3 identified characteristics relationships schoolrelated school related aspects outcomes Conclusion population health 19 202 6240 6 40 62,4 1 20 624 4 62,

Objective: To determine clinical outcomes and mortality risk factors related to mental disorders in a cohort of hospitalized patients with Covid-19 in Brazil. Methods: This retrospective cohort study used a Brazilian database called the Sistema de Vigilância Epidemiológica da Gripe (Influenza Epidemiological Surveillance System) to analyze patients aged ≥ 18 years who were hospitalized with Covid-19 between 2020 and 2022. The exposure of interest was mental disorders (anxiety, depression, schizophrenia, and bipolar disorder) identified through self-report. The primary outcome was in-hospital mortality. Covariates included demographic and clinical characteristics. Descriptive statistics, t-tests, chi-square tests, and binary logistic regression were used to analyze the data. Results: A cohort of 2,124,285 patients was included in the analysis, with 23,246 individuals (1.1%) self-reporting mental disorders, of which depression was the most prevalent (52.3%). The mortality rate of patients with mental disorders was 30.8%. Age, sex, region, dyspnea, low oxygen saturation, and comorbidities were associated with a higher mortality risk, as was schizophrenia (adjusted OR: 1.68; 95%CI 1.54-1.81). Conclusions: Individuals with schizophrenia had a greater likelihood of Covid-19-related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on Covid-19 mortality. Objective Covid19 Covid 19 Covid-1 Brazil Methods Influenza System 1 202 2022 anxiety, anxiety (anxiety disorder selfreport. selfreport self report. report self-report inhospital hospital characteristics statistics ttests, ttests t tests t-tests chisquare chi square data Results 2124285 2 124 285 2,124,28 analysis 23246 23 246 23,24 1.1% 11 (1.1% selfreporting reporting 52.3%. 523 52.3% . 52 3 (52.3%) 308 30 8 30.8% Age sex region dyspnea saturation adjusted OR 1.68 168 68 95CI CI 95 1.541.81. 154181 1.54 1.81 54 81 1.54-1.81) Conclusions Covid19related Covidrelated conditions Covid1 Covid- 20 212428 12 28 2,124,2 2324 24 23,2 1.1 (1.1 52.3 5 (52.3% 30.8 1.6 16 6 9 541 1.541.81 15418 154 1.5 181 1.8 1.54-1.81 21242 2,124, 232 23, 1. (1. 52. (52.3 30. 1.541.8 1541 15 1.54-1.8 2124 2,124 (1 (52. 1.541. 1.54-1. 212 2,12 ( (52 1.541 1.54-1 21 2,1 (5 1.54- 2,

This is the first of two documents prepared by experts for the Brazilian S20 mental health report. These reports outline strategies aimed at addressing the exacerbated mental health challenges arising from a post-pandemic world. Ongoing psychiatric epidemiology research has yielded evidence linking mental health with intricate social determinants, including gender, race/ethnicity, racism, socioeconomic status, social deprivation, and employment. More recently, the focus has expanded to also encompass violence and social oppression. By prioritizing prevention and early intervention, harnessing technology, and fostering community support, we can mitigate the long-term impact of emerging mental disorders throughout the life course. By utilizing evidence-based practices and forging partnerships between the health and education sectors, S20 countries can promote the health and safety of their student population, paving the way for a more promising future for the next generations. The first document focuses on addressing the mental health concerns of vulnerable populations, catering to the needs of children, youth, and aging populations, assessing the current state of alcohol and drug addictions, scaling up psychosocial interventions in primary care, exploring the potential integration of health and educational systems, and emphasizing the imperative adoption of human rights in mental health policies. S S2 report postpandemic post pandemic world determinants gender raceethnicity race ethnicity race/ethnicity racism status deprivation employment recently oppression intervention technology support longterm long term course evidencebased based sectors population generations populations children youth addictions care systems policies

An integral part of Brazil’s public health system, psychiatric emergency services have been instrumental in improving qualified support for crisis situations involving mental disorders in an equitable, universally accessible, and humanized way. The purpose of this article is to present a systematic review and consensus on the infrastructure and the ideal team for psychiatric emergencies services in Brazil. The authors searched electronic databases including MEDLINE (PubMed), SciELO, and Cochrane, in addition to documents from the World Health Organization, the Brazilian Ministry of Health, and other authorities. Of the 6839 manuscripts found, 46 were included. The content analysis summarized consensus statements through the Delphi method, and, after a series of interactive versions, a final report was produced. Models for changing psychiatric emergency services are assessed. It was determined that the emergency care network must be supervised by qualified management, and all health equipment and units must be effectively integrated. Psychiatric emergency services need adequate infrastructure, qualified staff (including a psychiatrist), sufficient consultation and observation space, tools and resources for differential diagnosis, training for all staff members, and communication with the health care network to facilitate referrals following patient discharge. Standardized models should be available to public health managers to guide the development of new services and adjust existing ones, always seeking improvement. The authors propose a model of psychiatric emergency services. Brazils Brazil s system equitable accessible way PubMed, PubMed , (PubMed) SciELO Cochrane Organization authorities 683 found 4 included method versions produced assessed management integrated psychiatrist, psychiatrist psychiatrist) space diagnosis members discharge ones improvement (PubMed 68 6

Objective: To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) for attention deficit/hyperactivity disorder (ADHD). Methods: Randomized sham-controlled trials were identified in major databases from January 1990 to January 2023. The primary outcome was overall improvement in ADHD symptoms. Subgroup analysis focused on the efficacy of rTMS in different brain regions. Secondary outcomes were the association of rTMS with improvement in different ADHD symptoms. Outcomes were expressed as effect size based on standardized mean difference (SMD)(continuous data), and ORs with 95%CI (categorical data). Results: A meta-analysis of six randomized sham-controlled trials involving 169 participants demonstrated no difference in overall ADHD symptoms between those treated with rTMS and sham controls (SMD = -0.24, p = 0.17). Subgroup analysis revealed that rTMS was more efficacious than sham treatment when targeting the right prefrontal cortex (SMD = -0.49, p = 0.03) but not the left prefrontal cortex (SMD = 0.01, p = 0.67). rTMS treatment was correlated with greater improvement in inattention (SMD = -0.76, p = 0.0002), but not hyperactivity (p = 0.86), impulsivity (p = 0.41), or depression symptoms (p = 0.95). The apparently higher risk of dropout in the rTMS group than the sham control group was not statistically significant (OR = 1.65, p = 0.26). Conclusion: This review found that rTMS only had therapeutic efficacy for ADHD symptoms (particularly inattention) when targeting the right prefrontal cortex. Further large-scale randomized sham-controlled trials are required to verify our findings. Registration number: PROSPERO CRD42023393713. Objective (rTMS deficithyperactivity deficit ADHD. . (ADHD) Methods shamcontrolled controlled 199 2023 regions SMDcontinuous SMD continuous data, data , data) 95CI CI 95 categorical data. Results metaanalysis meta 16 0.24, 024 0 24 -0.24 0.17. 017 0.17 17 0.17) 0.49, 049 49 -0.49 0.03 003 03 001 01 0.01 0.67. 067 0.67 67 0.67) 0.76, 076 76 -0.76 0.0002, 00002 0.0002 0002 0.0002) 0.86, 086 0.86 86 0.86) 0.41, 041 0.41 41 0.41) 0.95. 095 0.95 0.95) OR 165 1 65 1.65 0.26. 026 0.26 26 0.26) Conclusion particularly largescale large scale findings number CRD42023393713 CRD (ADHD 19 202 9 0.24 02 2 -0.2 0.1 0.49 04 4 -0.4 0.0 00 06 0.6 6 0.76 07 7 -0.7 0000 0.000 000 08 0.8 8 0.4 09 0.9 1.6 0.2 CRD4202339371 20 -0. 0. 0.7 0.00 1. CRD420233937 -0 CRD42023393 - CRD4202339 CRD420233 CRD42023 CRD4202 CRD420 CRD42 CRD4

This is the second part of the Brazilian S20 mental health report. The mental health working group is dedicated to leveraging scientific insights to foster innovation and propose actionable recommendations for implementation in Brazil and participating countries. In addressing the heightened mental health challenges in a post-pandemic world, strategies should encompass several key elements. This second part of the S20 Brazilian Mental Health Report will delve into some of these elements, including: the impact of climate change on mental health, the influence of environmental factors on neurodevelopmental disorders, the intersection of serious mental illness and precision psychiatry, the co-occurrence of physical and mental disorders, advancements in biomarkers for mental disorders, the use of digital health in mental health care, the implementation of interventional psychiatry, and the design of innovative mental health systems that integrate principles of innovation and human rights. Reassessing the treatment settings for psychiatric patients in general hospitals, where their mental health and physical needs are addressed, should be prioritized in mental health policy. As the S20 countries prepare for the future, we need principles that can advance innovation, uphold human rights, and strive for the highest standards in mental health care. S S2 report postpandemic post pandemic world elements including disorders psychiatry cooccurrence co occurrence care rights hospitals addressed policy future