Abstract Objective: Postpartum hemorrhage (PPH) is the leading cause of maternal death globally. Therefore, prevention strategies have been created. The study aimed to evaluate the occurrence of PPH and its risk factors after implementing a risk stratification at admission in a teaching hospital. Methods: A retrospective cohort involving a database of SISMATER® electronic medical record. Classification in low, medium, or high risk for PPH was performed through data filled out by the obstetrician-assistant. PPH frequency was calculated, compared among these groups and associated with the risk factors. Results: The prevalence of PPH was 6.8%, 131 among 1,936 women. Sixty-eight (51.9%) of them occurred in the high-risk group, 30 (22.9%) in the medium-risk and 33 (25.2%) in the low-risk group. The adjusted-odds ratio (OR) for PPH were analyzed using a confidence interval (95% CI) and was significantly higher in who presented multiple pregnancy (OR 2.88, 95% CI 1.28 to 6.49), active bleeding on admission (OR 6.12, 95% CI 1.20 to 4.65), non-cephalic presentation (OR 2.36, 95% CI 1.20 to 4.65), retained placenta (OR 9.39, 95% CI 2.90 to 30.46) and placental abruption (OR 6.95, 95% CI 2.06 to 23.48). Vaginal delivery figured out as a protective factor (OR 0.58, 95% CI 0.34 to 0.98). Conclusion: Prediction of PPH is still a challenge since its unpredictable factor arrangements. The fact that the analysis did not demonstrate a relationship between risk category and frequency of PPH could be attributable to the efficacy of the strategy: Women classified as "high-risk" received adequate medical care, consequently. Objective (PPH globally Therefore created hospital Methods SISMATER record low medium obstetricianassistant. obstetricianassistant obstetrician assistant. assistant obstetrician-assistant calculated Results 68 6 8 6.8% 13 1936 1 936 1,93 women Sixtyeight Sixty eight 51.9% 519 51 9 (51.9% highrisk group 3 22.9% 229 22 (22.9% mediumrisk 25.2% 252 25 2 (25.2% lowrisk adjustedodds adjusted odds OR 95 (95 288 88 2.88 128 28 1.2 6.49, 649 6.49 , 49 6.49) 612 12 6.12 120 20 4.65, 465 4.65 4 65 4.65) noncephalic non cephalic 236 36 2.36 939 39 9.39 290 90 2.9 30.46 3046 46 695 6.95 206 06 2.0 23.48. 2348 23.48 . 23 48 23.48) 058 0 58 0.58 034 34 0.3 0.98. 098 0.98 98 0.98) Conclusion arrangements strategy "high-risk care consequently 6.8 193 93 1,9 51.9 5 (51.9 22.9 (22.9 25.2 (25.2 (9 2.8 1. 64 6.4 61 6.1 4.6 2.3 9.3 29 2. 30.4 304 69 6.9 234 23.4 05 0.5 03 0. 09 0.9 6. 19 1, 51. (51. 22. (22. 25. (25. ( 4. 9. 30. 23. (51 (22 (25 (5 (2

Abstract RhD alloimmunization in pregnancy is still the main cause of hemolytic disease of the fetus and neonate (HDFN). Nevertheless, there are other antigens that may be associated with the occurrence of this phenomenon and that have been growing in proportion, given that current prevention strategies focus only on anti-RhD antibodies. Although not widespread, the screening and diagnostic management of the disease caused by these antibodies has recommendations in the literature. For this reason, the following review was carried out with the objective of listing the main red blood cell antigen groups described — such as Rh, ABO, Kell, MNS, Duffy, Kidd, among others — addressing the clinical importance of each one, prevalence in different countries, and recommended management when detecting such antibodies during pregnancy. HDFN. HDFN . (HDFN) Nevertheless proportion antiRhD anti widespread literature reason Rh ABO Kell MNS Duffy Kidd one countries (HDFN

Abstract Objective: To present a series of cases with our initial experience and short-term outcomes of a modified vaginal mucosal flap urethroplasty. Methods: Patients diagnosed with urethral stricture and operated by the same operative technique between January 2012 and January 2018 were followed for at least 6 months. Uroflowmetry and clinical outcomes were evaluated. Results: Nineteen patients were included with an average age of 56.4 years, mean preoperative Qmax of 5.3 ml/s, and PVR of 101.4 mL. After 6 months of the procedure, the mean Qmax improved to 14.7 mL/s (p<0.05), PVR decreased to 47.3 mL (p<0.05), and 84.2% of all patients reported improvement in clinical self-reported symptoms. There was an improvement in symptoms such as voiding effort in 84.2% of patients, weak stream (89.5%), and recurrent urinary tract infection (85.7%). The success rate (absence of symptoms and normal Qmax with no significant PVR) of the procedure was 84.2%. Conclusion: The described technique was considered effective for the treatment of female urethra stricture, with a high clinical success rate and an objective improvement of Qmax and decrease in PVR after 6 months of the procedure. Objective shortterm short term urethroplasty Methods 201 evaluated Results 564 56 4 56. years 53 5 3 5. mls ml s ml/s 1014 101 101. 147 14 7 14. mLs p<0.05, p005 p p<0.05 , 0 05 (p<0.05) 473 47 47. 842 84 2 84.2 selfreported self 89.5%, 895 89.5% 89 (89.5%) 85.7%. 857 85.7% . 85 (85.7%) absence Conclusion 20 10 1 p00 p<0.0 (p<0.05 8 84. 89.5 (89.5% 85.7 (85.7% p0 p<0. (p<0.0 89. (89.5 85. (85.7 p<0 (p<0. (89. (85. p< (p<0 (89 (85 (p< (8 (p (

Abstract Objective: Dysmenorrhea is the pain related to menstruation; to screen for the symptoms, a working ability, location, intensity of days of pain, and dysmenorrhea (WaLIDD) score was created. The purpose of this work was to culturally adapt and assess the measurement properties of the WaLIDD score for dysmenorrhea in Brazilian women. Methods: In this cross-sectional online study, we evaluated women with and without dysmenorrhea. Criterion validity and construct validity were assessed, respectively, by the Receiver Operator Characteristic (ROC) curve and correlations with the bodily pain and social functioning domains of medical outcomes study 36-item short-form health survey (SF-36), self-report of absenteeism and Stanford Presenteeism Scale for presenteeism. Test-retest reliability and measurement errors were assessed, respectively, by intraclass correlation coefficient (ICC) and Bland and Altman Graph. Results: 430 women completed the test, 238 (55.4%) women had dysmenorrhea, and 199 (46.3%) answered the questionnaire twice for the retest. The cutoff points ≥4, ≥5, and ≥5 could discriminate between women with and without dysmenorrhea, absenteeism, and presenteeism related to dysmenorrhea, respectively. Correlations between SF-36 – pain and social functioning domains and WaLIDD score were weak to strong and negative. For WaLIDD total Score, ICC was 0.95 and the limits of agreement were −1.54 and 1.62. Conclusion: WaLIDD score is a short, valid and reliable instrument to screen and predict dysmenorrhea and could predict absenteeism and presenteeism related to dysmenorrhea in Brazilian women. Objective menstruation symptoms ability location (WaLIDD created Methods crosssectional cross sectional assessed respectively ROC (ROC 36item item 36 shortform short form SF36, SF36 SF , (SF-36) selfreport self report Testretest Test retest (ICC Graph Results 43 test 23 55.4% 554 55 4 (55.4% 19 46.3% 463 46 3 (46.3% ≥4 5 ≥ SF-3 negative Score 095 0 95 0.9 154 1 54 −1.5 162 62 1.62 Conclusion SF3 (SF-36 2 55.4 (55.4 46.3 (46.3 SF- 09 9 0. 15 −1. 16 6 1.6 (SF-3 55. (55. 46. (46. −1 1. (SF- (55 (46 − (SF (5 (4 (

Abstract Objective: The aims of the study are to describe the association of coronavirus disease (COVID-19) with the abnormal histopathological findings in human placenta and to highlight the potential predictors of these histopathological findings. Methods: A retrospective cohort study, held in two obstetric units from January 2021- 2022, 34 patients who were confirmed cases of COVID- 19 were followed up till the time of delivery as their placenta were sent for histopathology. Patients diagnosed with other viral infections, chorioamnionitis, or were known case of as pre-term or term pre labour rupture of membrans (PROM) were excluded as well as pre exisiting diabetes mellitus or pre-eclampsia. Data analysis were performed using STATA software version 16. Result: Specific histopatological findings (fetal vascular malperfusion, maternal vascular malperfusion, inflammatory pathology and thrombotic finding) were significantly high among 13 (38.2%) of the study group who got infected earlier in pregnancy (P<0.001). The period between the diagnosis of COVID-19 and the delivery significantly increases the odds of the presence of pathological findings by 2.75 times for each week the patients getting infected earlier. Conclusion: Association of abnormal placental histopathological findings with COVID-19 infection in pregnancy and the potential predictor for the occurrence of placental findings is the longer duration between the diagnosis of the infection and the delivery. Objective COVID19 COVID (COVID-19 Methods 2021 2022 3 1 histopathology infections chorioamnionitis preterm PROM (PROM preeclampsia. preeclampsia eclampsia. eclampsia pre-eclampsia 16 Result fetal malperfusion finding 38.2% 382 38 2 (38.2% P<0.001. P0001 P P<0.001 . 0 001 (P<0.001) COVID-1 275 75 2.7 Conclusion COVID1 (COVID-1 202 38.2 (38.2 P000 P<0.00 00 (P<0.001 27 7 2. (COVID- 20 38. (38. P00 P<0.0 (P<0.00 (COVID (38 P0 P<0. (P<0.0 (3 P<0 (P<0. ( P< (P<0 (P< (P

Abstract BI-RADS® is a standardization system for breast imaging reports and results created by the American College of Radiology to initially address the lack of uniformity in mammography reporting. The system consists of a lexicon of descriptors, a reporting structure with final categories and recommended management, and a structure for data collection and auditing. It is accepted worldwide by all specialties involved in the care of breast diseases. Its implementation is related to the Mammography Quality Standards Act initiative in the United States (1992) and breast cancer screening. After its initial creation in 1993, four additional editions were published in 1995, 1998, 2003 and 2013. It is adopted in several countries around the world and has been translated into 6 languages. Successful breast cancer screening programs in high-income countries can be attributed in part to the widespread use of BI-RADS®. This success led to the development of similar classification systems for other organs (e.g., lung, liver, thyroid, ovaries, colon). In 1998, the structured report model was adopted in Brazil. This article highlights the pioneering and successful role of BI-RADS®, created by ACR 30 years ago, on the eve of publishing its sixth edition, which has evolved into a comprehensive quality assurance tool for multiple imaging modalities. And, especially, it contextualizes the importance of recognizing how we are using BI-RADS® in Brazil, from its implementation to the present day, with a focus on breast cancer screening. BIRADS® BIRADS BI RADS® RADS BI-RADS descriptors management auditing diseases 1992 (1992 1993 1995 1998 200 2013 languages highincome high income BIRADS®. RADS®. e.g., eg e g (e.g. lung liver thyroid ovaries colon. colon . colon) Brazil BIRADS®, RADS®, 3 ago edition modalities And especially day 199 (199 20 201 e.g. (e.g 19 (19 2 e.g 1 (1 (

Abstract Objective: To compare the medical image interpretation's time between the conventional and automated methods of breast ultrasound in patients with breast lesions. Secondarily, to evaluate the agreement between the two methods and interobservers. Methods: This is a cross-sectional study with prospective data collection. The agreement's degrees were established in relation to the breast lesions's ultrasound descriptors. To determine the accuracy of each method, a biopsy of suspicious lesions was performed, considering the histopathological result as the diagnostic gold standard. Results: We evaluated 27 women. Conventional ultrasound used an average medical time of 10.77 minutes (± 2.55) greater than the average of 7.38 minutes (± 2.06) for automated ultrasound (p<0.001). The degrees of agreement between the methods ranged from 0.75 to 0.95 for researcher 1 and from 0.71 to 0.98 for researcher 2. Among the researchers, the degrees of agreement were between 0.63 and 1 for automated ultrasound and between 0.68 and 1 for conventional ultrasound. The area of the ROC curve for the conventional method was 0.67 (p=0.003) for researcher 1 and 0.72 (p<0.001) for researcher 2. The area of the ROC curve for the automated method was 0. 69 (p=0.001) for researcher 1 and 0.78 (p<0.001) for researcher 2. Conclusion: We observed less time devoted by the physician to automated ultrasound compared to conventional ultrasound, maintaining accuracy. There was substantial or strong to perfect interobserver agreement and substantial or strong to almost perfect agreement between the methods. Objective interpretations interpretation s Secondarily interobservers Methods crosssectional cross sectional collection agreements lesionss descriptors performed standard Results 2 women 1077 10 77 10.7 ± ( 2.55 255 55 738 7 38 7.3 2.06 206 06 p<0.001. p0001 p p<0.001 . 0 001 075 75 0.7 095 95 0.9 071 71 098 98 researchers 063 63 0.6 068 68 067 67 p=0.003 p0003 003 (p=0.003 072 72 (p<0.001 6 p=0.001 (p=0.001 078 78 Conclusion 107 10. 2.5 25 5 73 3 7. 2.0 20 p000 p<0.00 00 07 09 9 p=0.00 (p=0.00 (p<0.00 p00 p<0.0 p=0.0 (p=0.0 (p<0.0 p0 p<0. p=0. (p=0. (p<0. p<0 p=0 (p=0 (p<0 p< p= (p= (p< (p

Abstract Objective: To analyze data of patients with symptomatic pelvic organ prolapse evaluated with PFDI20 and its subscales to report the prevalence of lower gastrointestinal symptoms and anal incontinence in the population of a public hospital and analyze its impact on quality of life. Methods: Cross-sectional study of patients with symptomatic POP. Patients were evaluated with demographic data, POP-Q, pelvic floor ultrasonography, urological parameters, and pelvic floor symptoms (PFDI-20), and quality of life (P-QoL) surveys. Patients were classified as CRADI-8 "positive" for colorectal symptoms, with responses "moderate" in at least 3 and/or "severe" in at least 2 of the items in the CRADI-8 questionnaires. Results: One hundred thirteen patients were included. 42.5% (48) were considered positive for colorectal symptoms on CRADI-8. 53.4% presented anal incontinence. No significant differences were found in sociodemographic variables, POP-Q stage, ultrasound parameters, or urological parameters. Positive patients had a significantly worse result in PFDI-20, POPDI (48 vs 28; p<0.001), UDI6 (51 vs 24; p<0.001), and in the areas of social limitation (44.4 vs 22.2; p = 0.045), sleep- energy (61.5 vs 44.4; p = 0.08), and severity (56.8 vs 43.7, p=0.015) according to P-QoL. Conclusion: Moderate or severe colorectal symptoms are seen in 40% of patients with symptomatic POP in our unit. Full evaluation of pelvic floor dysfunction symptoms should be performed routinely in urogynecology units. (FONIS SA12I2I53 - NCT02113969). Objective PFDI PFDI2 Methods Crosssectional Cross sectional POPQ, POPQ Q, Q ultrasonography parameters PFDI20, 20 , (PFDI-20) PQoL P QoL (P-QoL surveys CRADI8 CRADI 8 CRADI- "positive moderate "moderate andor "severe questionnaires Results included 425 42 5 42.5 48 CRADI8. 8. 534 53 4 53.4 variables stage 20, PFDI-20 (4 28 p<0.001, p0001 p<0.001 0 001 p<0.001) UDI 51 (5 24 44.4 444 44 (44. 22.2 222 22 0.045, 0045 0.045 045 0.045) sleep 61.5 615 61 (61. 0.08, 008 0.08 08 0.08) 56.8 568 56 (56. 437 43 7 43.7 p=0.015 p0015 015 PQoL. QoL. P-QoL Conclusion 40 unit units FONIS SAII SA I SA12I2I5 NCT02113969. NCT02113969 NCT . NCT02113969) (PFDI-20 42. 53. PFDI-2 ( p000 p<0.00 00 44. (44 22. 004 0.04 04 61. 6 (61 0.0 56. (56 43. p=0.01 p001 01 SA12I2I NCT0211396 (PFDI-2 PFDI- p00 p<0.0 (6 0. p=0.0 NCT021139 (PFDI- p0 p<0. p=0. NCT02113 (PFDI p<0 p=0 NCT0211 p< p= NCT021 NCT02 NCT0

Abstract Objective: To identify sociodemographic and reproductive risk factors associated with MetS in women in their fourth decade of life. Methods: Cohort study conducted on women born from June 1978 to May 1979 in Ribeirão Preto, Brazil. Sociodemographic, clinical, and obstetric data were collected by interview and clinical evaluation. Univariable and multivariable binomial logistic regression models were constructed to identify the risk factors of metabolic syndrome and the adjusted relative risk (RR) was calculated. Results: The cohort included 916 women, and 286 (31.2%) of them have metabolic syndrome. MetS was associated with lack of paid work (RR 1.49; 95% CI 1.14-1.95), marital status of without a partner (RR 1.33; 95% CI 1.03-1.72), low educational level (less than 8 years of schooling [RR 1.72; 95% CI 1.23-2.41], 8 to 12 years of schooling [RR 1.37; 95% CI 1.06-1.76], when compared with more than 12 years of schooling), and teenage pregnancy (RR 2.00; 95% CI 1.45-2.77). There was no association between MetS, and the other covariates studied. Conclusion: Metabolic syndrome in a population of women in the fourth decade of life was associated with lack of employment, lack of a partner, low educational level, and teenage pregnancy. Objective Methods 197 Preto Brazil Sociodemographic evaluation RR calculated Results 91 28 31.2% 312 31 2 (31.2% 1.49 149 1 49 95 1.141.95, 114195 1.14 1.95 , 14 1.14-1.95) 1.33 133 33 1.031.72, 103172 1.03 1.72 03 72 1.03-1.72) less 172 1.232.41, 123241 1.23 2.41 23 41 1.23-2.41] 1.37 137 37 1.061.76, 106176 1.06 1.76 06 76 1.06-1.76] schooling, schooling) 2.00 200 00 1.452.77. 145277 1.45 2.77 . 45 77 1.45-2.77) studied Conclusion employment 19 9 31.2 3 (31.2 1.4 4 141 1.141.95 11419 114 1.1 195 1.9 1.14-1.95 1.3 13 031 1.031.72 10317 103 1.0 1.7 0 7 1.03-1.72 17 232 1.232.41 12324 123 1.2 241 2.4 1.23-2.41 061 1.061.76 10617 106 176 1.06-1.76 2.0 20 452 1.452.77 14527 145 277 2.7 1.45-2.77 31. (31. 1. 1.141.9 1141 11 1.14-1.9 1.031.7 1031 10 1.03-1.7 1.232.4 1232 24 2. 1.23-2.4 1.061.7 1061 1.06-1.7 1.452.7 1452 27 1.45-2.7 (31 1.141. 1.14-1. 1.031. 1.03-1. 1.232. 1.23-2. 1.061. 1.06-1. 1.452. 1.45-2. (3 1.141 1.14-1 1.031 1.03-1 1.232 1.23-2 1.061 1.06-1 1.452 1.45-2 ( 1.14- 1.03- 1.23- 1.06- 1.45-

Abstract Endometriosis is a complex disease that affects 10-15% of women of reproductive age. Familial studies show that relatives of affected patients have a higher risk of developing the disease, implicating a genetic role for this disorder. Little is known about the impact of germline genomic copy number variant (CNV) polymorphisms on the heredity of the disease. In this study, we describe a rare CNV identified in two sisters with familial endometriosis, which contain genes that may increase the susceptibility and progression of this disease. We investigated the presence of CNVs from the endometrium and blood of the sisters with endometriosis and normal endometrium of five women as controls without the disease using array-CGH through the Agilent 2x400K platform. We excluded common CNVs that were present in the database of genomic variation. We identified, in both sisters, a rare CNV gain affecting 113kb at band 3q12.2 involving two candidate genes: ADGRG7 and TFG. The CNV gain was validated by qPCR. ADGRG7 is located at 3q12.2 and encodes a G protein-coupled receptor influencing the NF-kappaβ pathway. TFG participates in chromosomal translocations associated with hematologic tumor and soft tissue sarcomas, and is also involved in the NF-kappa B pathway. The CNV gain in this family provides a new candidate genetic marker for future familial endometriosis studies. Additional longitudinal studies of affected families must confirm any associations between this rare CNV gain and genes involved in the NF-kappaβ pathway in predisposition to endometriosis. 1015% 1015 10 15% 15 10-15 age disorder (CNV study arrayCGH array CGH xK x K platform variation kb 3q122 q 3q12 2 3q12. ADGRG qPCR proteincoupled protein coupled NFkappaβ NF kappaβ sarcomas NFkappa kappa 101 1 10-1 3q1 10- 3q

Abstract Objective: To show the experience of a Latin American public hospital, with SNM in the management of either OAB, NOUR or FI, reporting feasibility, short to medium-term success rates, and complications. Methods: A retrospective cohort was conducted using data collected prospectively from patients with urogynecological conditions and referred from colorectal surgery and urology services between 2015 and 2022. Results: Advanced or basic trial phases were performed on 35 patients, 33 (94%) of which were successful and opted to move on Implantable Pulse Generator (GG) implantation. The average follow-up time after definitive implantation was 82 months (SD 59). Of the 33 patients undergoing, 27 (81%)reported an improvement of 50% or more in their symptoms at last follow-up. Moreover, 30 patients (90%) with a definitive implant reported subjective improvement, with an average PGI-I "much better" and 9 of them reporting to be "excellent" on PGI-I. Conclusion: SNM is a feasible and effective treatment for pelvic floor dysfunction. Its implementation requires highly trained groups and innovative leadership. At a nation-wide level, greater diffusion of this therapy among professionals is needed to achieve timely referral of patients who require it. Objective hospital OAB FI feasibility mediumterm medium term rates complications Methods 201 2022 Results 3 94% 94 (94% GG (GG followup follow up 8 SD 59. 59 . 59) undergoing 2 81%reported 81reported 81% 81 50 followup. up. Moreover 90% 90 (90% PGII PGI I much better excellent "excellent PGII. I. Conclusion dysfunction leadership nationwide nation wide level it 20 202 (94 5 (90 (9 (

Abstract Objectives: This study aims to correlate pelvic ultrasound with female puberty and evaluate the usual ultrasound parameters as diagnostic tests for the onset of puberty and, in particular, a less studied parameter: the Doppler evaluation of the uterine arteries. Methods: Cross-sectional study with girls aged from one to less than eighteen years old, with normal pubertal development, who underwent pelvic ultrasound examination from November 2020 to December 2021. The presence of thelarche was the clinical criterion to distinguish pubescent from non-pubescent girls. The sonographic parameters were evaluated using the ROC curve and the cutoff point defined through the Youden index (J). Results: 60 girls were included in the study. Uterine volume ≥ 2.45mL had a sensitivity of 93%, specificity of 90%, PPV of 90%, NPV of 93% and accuracy of 91% (AUC 0.972) for predicting the onset of puberty. Mean ovarian volume ≥ 1.48mL had a sensitivity of 96%, specificity of 90%, PPV of 90%, NPV of 97% and accuracy of 93% (AUC 0.966). Mean PI ≤ 2.75 had 100% sensitivity, 48% specificity, 62% PPV, 100% NPV and 72% accuracy (AUC 0.756) for predicting the onset of puberty. Conclusion: Pelvic ultrasound proved to be an excellent tool for female pubertal assessment and uterine and ovarian volume, the best ultrasound parameters for detecting the onset of puberty. The PI of the uterine arteries, in this study, although useful in the pubertal evaluation, showed lower accuracy in relation to the uterine and ovarian volume. Objectives particular parameter arteries Methods Crosssectional Cross sectional old development 202 2021 nonpubescent non J. J . (J) Results 6 245mL mL 2 45mL 93 90 90% 91 AUC 0.972 0972 0 972 148mL 1 48mL 96 96% 97 0.966. 0966 0.966 966 0.966) 275 75 2.7 100 48 62 72 0.756 0756 756 Conclusion 20 (J 9 0.97 097 096 0.96 27 7 2. 10 4 0.75 075 0.9 09 0.7 07 0.

Abstract Objective: We conducted a meta-analysis of randomized clinical trials evaluating the clinical effects of ferric carboxymaltose therapy compared to other intravenous iron in improving hemoglobin and serum ferritin in pregnant women. We also assessed the safety of ferric carboxymaltose vs. other intravenous iron. Data source: EMBASE, PubMed, and Web of Science were searched for trials related to ferric carboxymaltose in pregnant women, published between 2005 and 2021. We also reviewed articles from google scholar. The keywords "ferric carboxymaltose," "FCM," "intravenous," "randomized," "pregnancy," "quality of life," and "neonatal outcomes" were used to search the literature. The search was limited to pregnant women. Selection of studies: Studies related to ferric carboxymaltose in pregnancy were scanned. Observational studies, review articles, and case reports were excluded. Randomized studies in pregnant women involving ferric carboxymaltose and other intravenous iron formulations were shortlisted. Of 256 studies, nine randomized control trials were selected. Data collection: Two reviewers independently extracted data from nine selected trials Data synthesis: The final effect size for increase in hemoglobin after treatment was significant for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 0.89g/dl [95% confidence interval 0.27,1.51]). The final effect size for the increase in ferritin after treatment was more for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 22.53µg/L [-7.26, 52.33]). No serious adverse events were reported with ferric carboxymaltose or other intravenous iron. Conclusion: Ferric carboxymaltose demonstrated better efficacy than other intravenous iron in increasing hemoglobin and ferritin levels in treating iron deficiency anemia in pregnant women. Objective metaanalysis meta analysis vs source EMBASE PubMed 200 2021 scholar carboxymaltose, FCM, FCM "FCM, intravenous, "intravenous, randomized, "randomized, pregnancy, "pregnancy, quality life, life neonatal outcomes literature scanned excluded shortlisted 25 collection synthesis sucroseiron sucrose standard 089gdl gdl 0 89g dl g 95% 95 [95 0.27,1.51. 027151 0.27,1.51 . 27 1 51 0.27,1.51]) 2253µgL µgL 22 53µg L µg 7.26, 726 7 26 [-7.26 52.33. 5233 52.33 52 33 52.33]) Conclusion 20 202 "FCM "intravenous "randomized "pregnancy 2 9 [9 02715 0.27,1.5 5 0.27,1.51] 7.26 72 [-7.2 523 52.3 3 52.33] [ 0271 0.27,1. 7.2 [-7. 52. 027 0.27,1 7. [-7 02 0.27, [- 0.27 0.2 0.

Abstract Objective: To validate the 10-item Cervantes Scale (CS-10) among Brazilian women. Methods: This is a cross-sectional observational study involving women in the community aged 40–55 years in the Southern region of Brazil. They completed a general health, habits and socio-demographic questionnaire, the CS-10 and the Women’s Health Questionnaire (WHQ). Women unable to understand the survey, not consenting to participate, or having incapacity imposing difficulties during the completion of the questionnaire were excluded. A Confirmatory Factor Analysis (CFA) was conducted with the AMOS 16.0 software. Chi-square of degrees of freedom (χ2/df), the Comparative Fit Index (CFI), the Tucker-Lewis Index (TLI) and the Root-Mean-Square Error of Approximation (RMSEA) were used as indices of goodness of fit. Cronbach’s alpha coefficient was used for internal consistency. Results: A total of 422 women were included (premenopausal n=35, perimenopausal n=172, postmenopausal n=215). The CFA for the CS-10 showed a good fit (χ²/df=1.454, CFI=0.989; TLI=0.985; RMSEA=0.033; CI 90%=0.002-0.052; PCLOSE=0.921; Model p=0.049). Good reliability was established in CS-10 and WHQ (Cronbach’s alpha=0.724). Postmenopausal women had higher total CS-10 scores (p≤0.0001), reflecting worse quality of life (QoL) related to menopause symptoms and confirming the greater symptomatology evaluated by high total scores for WHQ found in this population when compared to those in the premenopausal period (p=0.041). Conclusion: The CS-10 is a consistent tool for health-related QoL in Brazilian mid-aged women. Objective 10item item 10 CS10 CS (CS-10 Methods crosssectional cross sectional 4055 40 55 40–5 Brazil health sociodemographic socio demographic CS-1 Womens s WHQ. . (WHQ) survey participate excluded (CFA 160 16 0 16. software Chisquare Chi square χ2/df, χ2df χdf χ2/df , χ2 df χ (χ2/df) CFI, CFI (CFI) TuckerLewis Tucker Lewis TLI (TLI RootMeanSquare Root Mean Square RMSEA (RMSEA Cronbachs Cronbach consistency Results 42 n35 n 35 n=35 n172 172 n=172 n=215. n215 n=215 215 n=215) χ²/df=1.454, χ²df1454 χ² 1 454 (χ²/df=1.454 CFI=0.989 CFI0989 989 TLI=0.985 TLI0985 985 RMSEA=0.033 RMSEA0033 033 90%=0.0020.052 9000020052 90%=0.002 0.052 90 002 052 90%=0.002-0.052 PCLOSE=0.921 PCLOSE0921 PCLOSE 921 p=0.049. p0049 p p=0.049 049 p=0.049) alpha=0.724. alpha0724 alpha=0.724 724 alpha=0.724) p≤0.0001, p00001 p≤0.0001 0001 (p≤0.0001) (QoL p=0.041. p0041 p=0.041 041 (p=0.041) Conclusion healthrelated midaged mid CS1 (CS-1 405 4 5 40– CS- (WHQ (χ2/df (CFI n3 3 n=3 n17 17 n=17 n21 n=21 21 χ²/df=1.454 χ²df145 45 (χ²/df=1.45 CFI=0.98 CFI098 98 TLI=0.98 TLI098 RMSEA=0.03 RMSEA003 03 0020 90%=0.0020.05 900002005 900002 90%=0.00 0052 0.05 9 00 05 90%=0.002-0.05 PCLOSE=0.92 PCLOSE092 92 p004 p=0.04 04 alpha072 alpha=0.72 72 p0000 p≤0.000 000 (p≤0.0001 (p=0.041 (CS- n= n1 n=1 n2 n=2 2 χ²/df=1.45 χ²df14 (χ²/df=1.4 CFI=0.9 CFI09 TLI=0.9 TLI09 RMSEA=0.0 RMSEA00 90%=0.0020.0 90000200 90000 90%=0.0 005 0.0 90%=0.002-0.0 PCLOSE=0.9 PCLOSE09 p00 p=0.0 alpha07 alpha=0.7 7 p000 p≤0.00 (p≤0.000 (p=0.04 (CS χ²/df=1.4 χ²df1 (χ²/df=1. CFI=0. CFI0 TLI=0. TLI0 RMSEA=0. RMSEA0 90%=0.0020. 9000020 9000 90%=0. 0. 90%=0.002-0. PCLOSE=0. PCLOSE0 p0 p=0. alpha0 alpha=0. p≤0.0 (p≤0.00 (p=0.0 χ²/df=1. χ²df (χ²/df=1 CFI=0 TLI=0 RMSEA=0 90%=0.0020 900 90%=0 90%=0.002-0 PCLOSE=0 p=0 alpha=0 p≤0. (p≤0.0 (p=0. χ²/df=1 (χ²/df= CFI= TLI= RMSEA= 90%= 90%=0.002- PCLOSE= p= alpha= p≤0 (p≤0. (p=0 χ²/df= (χ²/df 90% p≤ (p≤0 (p= χ²/df (p≤ (p