ABSTRACT A young woman presented at our clinic with sudden visual loss in the right eye, recurrent vertigo, and right-sided tinnitus. We performed a complete ophthalmological evaluation. This revealed effects of the condition on the small arterioles of the peripheral retina. Susac syndrome is characterized by the clinical triad of retinal arteriolar occlusions, cochleovestibular manifestations, and encephalopathy (which can be identified by neuroimaging abnormalities). Early diagnosis and immunosuppressive therapy improved the patient's visual acuity and the remission of her other symptoms. Hemi-central retinal artery occlusion is an atypical neuro-ophthalmological finding in this disease. However, its identification as a sign of Susac syndrome may facilitate timely diagnosis and accurate treatment. eye vertigo rightsided sided tinnitus evaluation retina occlusions manifestations which abnormalities. abnormalities . abnormalities) patients patient s symptoms Hemicentral Hemi central neuroophthalmological neuro disease However treatment

Resumen Introducción: Las úlceras genitales constituyen un reto diagnóstico por sus múltiples etiologías. Uno de los casos a tener en cuenta en la población femenina son las úlceras de Lipschütz. El objetivo es presentar dos casos que se diagnosticaron en el año 2022 en una institución de tercer nivel en Boyacá, Colombia. Caso clínico 1: Paciente de 16 años. Ingresa por cuadro de 5 días con fiebre y aparición de lesiones ulceradas en el área genital. Se tomaron laboratorios para infecciones de transmisión sexual, negativos, con virus Epstein Barr IgG positiva. Se hospitalizó para tratamiento analgésico y antibiótico, y ante la sospecha de infecciones asociadas se tomó la decisión de llevar a desbridamiento y toma de biopsia. Ante la notable mejoría, se dio egreso días después. Caso clínico 2: Paciente de 19 años con discapacidad auditiva y visual, perteneciente a comunidad indígena. Acude por presencia de lesión genital de evolución desconocida. Se solicitaron laboratorios para descartar infecciones de transmisión sexual, Epstein Barr y Leishmania. Se tomó biopsia para descartar malignidad, con resultados negativos. Dermatología considera que se trata de úlcera de Lipschütz, se ajusta manejo ambulatorio y se le da egreso. Conclusiones: La identificación temprana de las lesiones en la región genital en las pacientes menores de edad mejora la sintomatología, tranquiliza a las jóvenes y sus familiares, descarta la asociación con enfermedades de transmisión sexual y disminuye procedimientos e ingresos hospitalarios en ocasiones innecesarios.

Abstract Introduction: Genital ulcers constitute a diagnostic challenge given their multiple etiologies. One of the cases to take into account in the female population is Lipschütz ulcers. The objective is to present two cases that were diagnosed in the year 2022 in a third level institution in Boyacá, Colombia. Case report 1: 16-year-old patient was admitted with fever for 5 days and the appearance of ulcerated lesions in the genital area. Laboratory tests for sexually transmitted infections were negative, with Epstein Barr virus IgG positive. The patient was hospitalized for analgesic and antibiotic treatment, and given the suspicion of associated infections, the decision was made to undergo debridement and take a biopsy. Given the notable improvement, he was discharged. Case report 2: 19-year-old patient with hearing and visual disabilities, belonging to an indigenous community, presented with a genital lesion of unknown evolution. Laboratories were requested to rule out sexually transmitted infections, Epstein Barr and Leishmania. A biopsy was taken to rule out malignancy, with negative results. Dermatology considers it to be a Lipschütz ulcer, therefore outpatient management is adjusted and gives discharge. Conclusions: The early identification of lesions in the genital region in underage patients improves symptoms, reassures young women and their families, ruling out the association with sexually transmitted diseases, and reducing procedures and hospital admissions on occasions unnecessary.

Abstract Introduction: Upper endoscopy is the standard method for diagnosing early-stage gastric cancer. However, according to estimates, up to 20% of tumors are not detected, and their accuracy may be affected by the variability in their performance. In Colombia, most diagnoses take place in advanced stages, which aggravates the problem. Protocols have been proposed to ensure the complete observation of areas prone to premalignant lesions to address variability. Objective: To build and validate an automatic audit system for endoscopies using artificial intelligence techniques. Methodology: In this study, 96 patients from a teaching hospital underwent video-documented endoscopies, spanning 22 stations rearranged to minimize overlaps and improve the identification of 13 key gastric regions. An advanced convolutional network was used to process the images, extracting visual characteristics, which facilitated the training of artificial intelligence in the classification of these areas. Results: the model, called Gastro UNAL, was trained and validated with images of 67 patients (70% of cases) and tested with 29 different patients (30% of cases), which reached an average sensitivity of 85,5% and a specificity of 98,8% in detecting the 13 gastric regions. Conclusions: The effectiveness of the model suggests its potential to ensure the quality and accuracy of endoscopies. This approach could confirm the regions evaluated, alerting less experienced or trained endoscopists about blind spots in the examinations, thus, increasing the quality of these procedures.

Resumen Introducción: La endoscopia digestiva alta es el método estándar para diagnosticar el cáncer gástrico en etapas tempranas. Sin embargo, su precisión puede verse afectada por la variabilidad en su realización, y se estiman hasta 20% de tumores no detectados. En Colombia, la mayoría de los diagnósticos se realizan en etapas avanzadas, lo que agrava el problema. Para abordar la variabilidad, se han propuesto protocolos con el fin de asegurar la observación completa de áreas propensas a lesiones premalignas. Objetivo: Construir y validar un sistema de auditoría automática para endoscopias usando técnicas de inteligencia artificial. Metodología: En este estudio, 96 pacientes de un hospital universitario se sometieron a endoscopias documentadas en video, abarcando 22 estaciones reorganizadas para minimizar solapamientos y mejorar la identificación de 13 regiones gástricas clave. Se utilizó una red convolucional avanzada para procesar las imágenes, extrayendo características visuales, lo que facilitó el entrenamiento de la inteligencia artificial en la clasificación de estas áreas. Resultados: El modelo, llamado Gastro UNAL, fue entrenado y validado con imágenes de 67 pacientes (70% de los casos) y probado con 29 pacientes distintos (30% de los casos), con lo que alcanzó una sensibilidad promedio del 85,5% y una especificidad del 98,8% en la detección de las 13 regiones gástricas. Conclusiones: La eficacia del modelo sugiere su potencial para asegurar la calidad y precisión de las endoscopias. Este enfoque podría confirmar las regiones evaluadas, alertando puntos ciegos en la exploración a los endoscopistas con menos experiencia o en entrenamiento, de tal forma que se aumente la calidad de estos procedimientos.

This study examines early mapping of complex DPs in prepositional relative clauses with for/to (‘para’), i.e. attributing the thematic role of beneficiary. The main question is whether the standard variant for this type of relative clauses in Brazilian Portuguese (with preposition) as compared to the non-standard chopped variant (without a preposition) allows for early referent mapping, given the possibility of incremental integration of preceding contextual visual and linguistic information. A picture matching experiment was applied to 41 speakers of the standard variety of BP. Preceding visual and auditory linguistic context was presented in which a character participated in two distinct events (one event presented with a di-transitive verb and another presented with a transitive verb), involving distinct co-participants. We aimed to verify whether the presentation of a standard variant probe question, with the preposition, immediately following the visual and linguistic contextual scenes would benefit early identification of the referent expressed in the complex DP, compared to a non-standard prepositionless (chopped variant) probe question. Accuracy and Reaction Time (RT) with regards to the picture matching task were the dependent variables. We also intended to examine the influence of knowledge of standard grammar as well as verbal working memory on task performance. Participants were asked to try and click on the image matching the probe sentence containing the relative clause as soon as possible. Our results did not reveal any advantage for the use of the standard prepositional relative clause compared to the non-standard version in terms of referent anticipation. However, accuracy of image selection was significantly higher for standard relative clauses. Higher scores in the standard grammar test and the reading span test were positively correlated to RT(s) as well as accuracy (for the non-standard relative clause). Relative clause complexity, possible ambiguity of the non-standard chopped relative clauses and the limited sensitivity of the task in detecting potential early mapping are all factors that seem to affect the results.

Este estudo investiga, particularmente, o mapeamento antecipado do referente de um DP complexo, apresentando uma oração relativa preposicionada com para, ou seja, com papel temático de beneficiário. Explora-se a contribuição que o tipo de estratégia relativa utilizada (padrão ou cortadora) pode trazer para a antecipação do referente, dada a possibilidade de integração incremental de informação contextual visual e linguística precedente. Em um experimento de seleção de imagem, aplicado a 41 participantes, falantes cultos de português do Brasil, a ser reportado, apresentaram-se contextos visuais e linguísticos auditivos prévios em que um personagem participa de dois eventos distintos (um evento apresentado com verbo bitransitivo e um evento apresentado com verbo transitivo), envolvendo coparticipantes distintas. Busca-se verificar em que medida o uso, na sentença-teste auditiva, que segue os preâmbulos discursivos e visuais, de uma estratégia padrão da língua, na qual a preposição aparece precedendo o pronome relativo, poderia favorecer a antecipação do referente do DP complexo, em comparação à estratégia cortadora, em que a preposição não está presente. Empregou-se uma tarefa de correspondência sentença-gravura na qual a acurácia e o tempo de resposta foram considerados como variáveis dependentes. Ademais, objetivou-se verificar a influência de conhecimento de norma padrão e de memória de trabalho verbal no desempenho da tarefa. Solicita-se que tentem clicar o mais rápido possível na imagem descrita pela sentença contendo a relativa. Nossos resultados não indicaram uma vantagem do uso da relativa padrão sobre a cortadora para a antecipação do referente do DP complexo. No entanto, a acurácia da seleção da imagem foi significativamente melhor para esse tipo de relativa. Melhor desempenho no teste normativo e no teste de reading span foi associado a TRs mais rápidos e maior acurácia na relativa cortadora. Fatores que parecem influenciar esse quadro são complexidade da estrutura relativa, possível ambiguidade da relativa cortadora e a sensibilidade limitada do teste para flagrar essa possível antecipação.

Resumo Muitas espécies de Cichla colonizaram com sucesso lagos e reservatórios do Brasil desde os anos 1960, causando graves prejuízos à vida selvagem nesses locais. Neste estudo, 135 tucunarés foram coletados em um complexo de reservatórios a fim de identificar se representavam uma espécie dominante ou múltiplas espécies, uma vez que diversas espécies de Cichla foram registradas na bacia. Os espécimes foram identificados com base na coloração, dados morfométricos e merísticos, e por marcadores mitocondriais COI, 16S rDNA e Região Controle (RC). A sobreposição dos dados morfométricos e o padrão similar de coloração impediram a identificação utilizando as chaves de identificação disponíveis na literatura. Entretanto, as análises bayesiana e de máxima verossimilhança de dados moleculares demonstraram a ocorrência de uma única espécie, Cichla kelberi. Um único haplótipo foi observado para o 16S e RC, enquanto três foram detectados para o COI, com um haplótipo dominante presente em 98,5% das amostras. A baixa diversidade nos exemplares introduzidos de C. kelberi evidenciou um número limitado de linhagens maternas fundadoras. O sucesso da invasão parece depender de fatores abióticos, como a maior transparência da água de ambientes lênticos que favorece predadores visuais que, atrelado à ausência de predadores, fez do C. kelberi um invasor bem-sucedido nesses reservatórios.

Abstract Several species of Cichla successfully colonized lakes and reservoirs of Brazil, since the 1960’s, causing serious damage to local wildlife. In this study, 135 peacock bass were collected in a reservoir complex in order to identify if they represented a single dominant species or multiple ones, as several Cichla species have been reported in the basin. Specimens were identified by color pattern, morphometric and meristic data, and using mitochondrial markers COI, 16S rDNA and Control Region (CR). Overlapping morphological data and similar coloration patterns prevented their identification using the taxonomic keys to species identification available in the literature. However, Bayesian and maximum likelihood from sequencing data demonstrated the occurrence of a single species, Cichla kelberi. A single haplotype was observed for the 16S and CR, while three were detected for COI, with a dominant haplotype present in 98.5% of the samples. The extreme low diversity of the transplanted C. kelberi evidenced a limited number of founding maternal lineages. The success of this colonization seems to rely mainly on abiotic factors, such as increased water transparency of lentic environments that favor visual predators that along with the absence of predators, have made C. kelberi a successful invader of these reservoirs.

Abstract Objectives Olfactory loss is a recognized long-term dysfunction after Coronavirus Disease 2019 (COVID-19) infection. This investigation aimed to assess the effect of alpha-lipoic acid as an adjuvant treatment of olfactory training on the improvement of smell loss in post-COVID-19 patients. Methods This randomized controlled trial included 128 adult outpatients who had persistent smell loss for more than 3-months after COVID-19 infection. The participants were randomly allocated into two groups: the intervention treatment group, which received alpha-lipoic acid associated to olfactory training, and comparison treatment group, which received placebo pills associated to olfactory training. The participants were followed-up for 12-weeks. Olfactory dysfunction was assessed in terms of Visual Analog Scale (VAS), and the Connecticut Chemosensory Clinical Research Center (CCCRC) test for the Brazilian population. Results A total of 100 participants completed the follow-up period and were analyzed in this study. Both groups have improved CCCRC score (p= 0.000), olfactory threshold (p= 0.000), identification score (p= 0.000) and VAS score (p= 0.000) after 12-weeks follow-up. No significant differences were determined between the intervention and comparison treatment groups in CCCRC score (p= 0.63), olfactory threshold (p= 0.50), identification score (p= 0.96) and VAS score (p= 0.97). In all these criteria, comparison treatment group went slightly worse. At the endpoint of the study, the frequency of anosmia reduced to 2% in the intervention treatment group and to 7.8% in the comparison treatment group. Also, 16.8% of the intervention group’ subjects, and 15.7% of comparison treatment group’s patients reached normosmia. Conclusions Overall, there was a strongly significant difference in olfactory function between baseline and endpoint for both groups. However, based on the lack of significant difference between the intervention treatment and the comparison treatment groups in terms of olfactory changes, our study appoints that the alpha-lipoic acid is not better than olfactory training alone to treat olfactory loss after COVID-19. Level of evidence Level 2. longterm long term 201 COVID19 COVID 19 (COVID-19 infection alphalipoic alpha lipoic postCOVID19 postCOVID post post-COVID-1 12 3months months 3 COVID-1 followedup followed up 12weeks. 12weeks weeks weeks. VAS, , (VAS) (CCCRC population 10 followup follow p= p (p 0.000, 0000 0.000 0 000 followup. up. 0.63, 063 0.63 63 0.63) 0.50, 050 0.50 50 0.50) 0.96 096 96 0.97. 097 0.97 . 97 0.97) criteria worse 2 78 7 8 7.8 Also 168 16 16.8 subjects 157 15 15.7 s normosmia Overall However changes COVID19. 19. 20 COVID1 1 (COVID-1 postCOVID1 post-COVID- COVID- (VAS 0.00 00 06 0.6 6 05 0.5 5 0.9 09 9 7. 16. 15. (COVID- post-COVID 0.0 0. (COVID

ABSTRACT The purpose of this study was to report the ocular changes observed after a bee sting with a stinger retained in the cornea. We show the treatment and outcome of an unusual corneal injury and its pathogenesis. This is a case report and literature review of ocular injuries caused by bee stings. A 63-year-old female patient sought emergency ophthalmic care because of a bee sting on the cornea of her right eye six days before. She complained of blurred vision, pain, and ocular hyperemia. She had glare sensitivity on visual acuity in the affected eye. Examination revealed moderate hyperemia of the bulbar conjunctiva, corneal edema with Descemet’s folds and a stinger lodged in the temporal region, in the deep stroma of the cornea. The patient was admitted to the operating room under general anesthesia. During surgery, the stinger had to be removed via the anterior chamber, by performing a paracentesis and washing the anterior chamber with a double flushing and balanced saline solution. There is still no standard treatment in the literature for patients with eye injuries caused by bee stings, and early identification and recognition of possible sight-threatening complications is important. pathogenesis stings 63yearold yearold 63 year old before vision pain conjunctiva Descemets Descemet s region anesthesia surgery solution sightthreatening sight threatening important 6

RESUMO O propósito deste estudo foi reportar as alterações oculares observadas após picada de abelha com ferrão retido na córnea. Destacamos o tratamento e o desfecho de uma lesão de córnea incomum e sua patogênese. Trata-se de relato de caso e revisão da literatura de lesões oculares por picada de abelha. Paciente do sexo feminino, 63 anos, procurou atendimento oftalmológico de urgência devido à picada de abelha na córnea do olho direito há 6 dias. Queixava-se de embaçamento visual, dor e hiperemia ocular. Apresentou acuidade visual de vultos no olho afetado. Ao exame, notaram-se hiperemia moderada de conjuntiva bulbar, edema corneano com dobras de Descemet e presença do ferrão alojado na região temporal, no estroma profundo da córnea. A paciente foi internada para ser abordada no centro cirúrgico sob anestesia geral. Durante a cirurgia, o ferrão teve que ser retirado via câmara anterior, mediante a realização de uma paracentese e uma lavagem da câmara anterior, com dupla via e solução salina balanceada. Ainda não existe na literatura um tratamento padrão na abordagem de pacientes com lesões oculares por picada de abelha, sendo importantes a identificação e o reconhecimento precoce de possíveis complicações que ameacem a visão. patogênese Tratase Trata se feminino anos dias Queixavase Queixava ocular afetado exame notaramse notaram bulbar temporal geral cirurgia anterior balanceada visão

ABSTRACT Collection management faces many challenges in keeping stored items preserved and the information associated with them accurate and organized. It is essential for the expansion and use of this biodiversity repository that the database is unambiguous and that errors are quickly identified and corrected. This work aims to show the use of interactive visual representations (IVRs) of the collection’s metadata as tools to inspect the data and help solve these challenges. To do this, we used the Annelida collection database from the National Museum (MN) of the Federal University of Rio de Janeiro (UFRJ). Interactive graphs of the metadata within this database (catalog date, taxonomic identification and determiners, sampling, depth, geographic localization, and collector data) were created with the Altair library in the Python 3 language. Data analyses using these graphs made it possible to identify anomalous patterns in the data and fill in missing records. They also provided an understanding of the spatial and bathymetric distribution of the specimens deposited over time, and the growth rate of the collection in each family, thus projecting future growth and solutions for the physical organization of vials. Graphs are an ally in the management of collections with digital entry forms and aim to facilitate the availability of metadata associated with cataloged specimens. Likewise, IVRs can even be used to give credit to the researchers involved in building biological collections. Thus, visualization tools are efficient in recognizing global patterns present in databases and solving biological collection management tasks. organized corrected (IVRs s MN (MN UFRJ. UFRJ . (UFRJ) catalog date determiners sampling depth localization language records time family vials Likewise Thus tasks (UFRJ

ABSTRACT In this study, we take as our object the tense structure of discourses expressed in Brazilian Sign Language. We aim to demonstrate how the process of identification of deaf subjects is discursivized and textualized in the video-poem V&V by Fernanda Machado (2017). Based on Greimas (1973), Floch (1985), and Zilberberg (2011), we analyzed the content plane and the expression plane of the poem, with a view to deducing abstract categories that predicate narrative, thematic and figurative paths on the content plane, as well as figures of expression which, when homologated with each other, establish semisymbolic structures of a tensive order on both planes of language. The results allow us to assume what we have called, based on terminology borrowed from Hall (1977), the tensive proxemics of the deaf subject’s identification process. On the level of expression, such tensive proxemics consists of a path that starts with public recognition and moves on to social, personal and, finally, intimate recognition between the deaf subject-actants. On the level of content, such recognition is compatible with the category of adherence vs. inherence to a deaf identity. study Language videopoem video poem VV V 2017. 2017 . (2017) 1973, 1973 , (1973) 1985, 1985 (1985) 2011, 2011 (2011) narrative which other language called 1977, 1977 (1977) subject s social finally subjectactants. subjectactants actants. actants subject-actants vs identity 201 (2017 197 (1973 198 (1985 (2011 (1977 20 (201 19 (197 (198 2 (20 1 (19 (2 (1 (

RESUMO Neste trabalho, tomamos como objeto a estrutura tensiva dos discursos manifestados em Língua Brasileira de Sinais. Objetivamos demonstrar como o processo de identificação dos sujeitos Surdos é discursivizado e textualizado no vídeo-poema V&V de Fernanda Machado (2017). Com base em Greimas (1973), Floch (1985) e Zilberberg (2011), analisamos plano de conteúdo e do plano de expressão do poema, com vistas a depreender categorias abstratas que predicam percursos narrativos, temáticos, figurativos, no plano de conteúdo, além de figuras da expressão, que, homologados entre si, estabelecem estruturas semissimbólicas de ordem tensiva em ambos os planos da linguagem. Os resultados permitem assumir o que temos denominado, a partir da terminologia emprestada de Hall (1977), como proxêmica tensiva do processo de identificação do sujeito Surdo que consiste, pelo plano de expressão, em um percurso que parte do reconhecimento público, depois social, pessoal e, por fim, íntimo entre os sujeitos-atuantes Surdos, o que, no plano de conteúdo, compatibiliza-se com a categoria aderência vs. inerência a uma identidade Surda. trabalho Sinais vídeopoema vídeo poema VV V 2017. 2017 . (2017) 1973, 1973 , (1973) 1985 (1985 2011, 2011 (2011) narrativos temáticos figurativos si linguagem denominado 1977, 1977 (1977) consiste público social fim sujeitosatuantes atuantes compatibilizase compatibiliza se vs Surda 201 (2017 197 (1973 198 (198 (2011 (1977 20 (201 19 (197 (19 2 (20 1 (1 (2 (

Objetivo: analizar la integridad de mascarillas N95/PFF2 con relación a la morfología de las fibras, porosidad, grietas y microagujeros, así como identificar daños visibles en su estructura y componentes, luego de protocolos de reutilización de siete y quince días. Método: estudio transversal. Se analizaron las características estructurales y morfológicas de una mascarilla N95/PFF2 nueva en comparación con las mascarillas N95/PFF2 (n=10) utilizadas en protocolos de siete y quince días, mediante inspección visual y microscopía electrónica de barrido. Resultados: tras la inspección visual, siguiendo el protocolo de siete días, el 40% y el 60% de las mascarillas N95/PFF2 mostraron, respectivamente, marcas de identificación personal y suciedad externa e interna. Además, el 20% presentó aflojamiento y/o desgarro de las correas de sujeción, mientras que el 100% presentó algún tipo de daño en los clips nasales. En el protocolo de quince días, todas las mascarillas N95/PFF2 tenían suciedad, correas de sujeción sueltas y clips nasales dañados, y el 80% tenía pliegues. La microscopía electrónica reveló un aumento de poros y aflojamiento en las tramas a partir de los siete días, extendiéndose hasta los quince días, con presencia de microagujeros y residuos. Conclusión: la reutilización de las mascarillas N95/PFF2 compromete su integridad estructural y morfológica. Es crucial realizar pruebas para medir el impacto de esta práctica en la seguridad de los profesionales de la salud. Objetivo N95PFF2 NPFF N95 PFF2 N PFF N95/PFF fibras porosidad componentes días Método transversal n=10 n10 n 10 (n=10 barrido Resultados 40 60 mostraron respectivamente interna Además 20 yo o 100 dañados 80 pliegues residuos Conclusión morfológica salud N95PFF N9 n=1 n1 1 (n=1 4 6 2 8 n= (n= (n

Objetivo: analisar a integridade das máscaras N95/PFF2 em relação à morfologia das fibras, porosidade, fissuras e micro furos, bem como identificar danos visíveis em sua estrutura e componentes, após protocolos de reutilização de sete e quinze dias. Método: estudo transversal. Características estruturais e morfológicas de uma máscara N95/PFF2 nova foram analisadas em comparação com máscaras N95/PFF2 (n=10) utilizadas em protocolos de sete e quinze dias, por meio da inspeção visual e microscopia eletrônica de varredura. Resultados: na inspeção visual, seguindo o protocolo de sete dias, 40% e 60% das máscaras N95/PFF2 apresentaram, respectivamente, marcas de identificação pessoal e sujidades externas e internas. Além disso, 20% exibiram afrouxamento e/ou rompimento das tiras de fixação, enquanto 100% mostraram algum tipo de dano nos clipes nasais. No protocolo de quinze dias, todas as máscaras N95/PFF2 apresentavam sujidade, tiras de fixação frouxas e clipes nasais comprometidos; 80% possuíam dobras. A microscopia eletrônica revelou aumento dos poros e afrouxamento nas tramas a partir de sete dias, ampliando-se até quinze dias, com presença de micro furos e detritos. Conclusão: a reutilização das máscaras N95/PFF2 compromete a integridade estrutural e morfológica. É crucial realizar testes para mensurar o impacto dessa prática na segurança dos profissionais de saúde. Objetivo N95PFF2 NPFF N95 PFF2 N PFF N95/PFF fibras porosidade componentes dias Método transversal n=10 n10 n 10 (n=10 varredura Resultados 40 60 apresentaram respectivamente internas disso 20 eou ou 100 sujidade comprometidos 80 dobras ampliandose ampliando se detritos Conclusão morfológica saúde N95PFF N9 n=1 n1 1 (n=1 4 6 2 8 n= (n= (n

Objective: to analyze the integrity of N95/PFF2 masks in relation to fiber morphology, porosity, cracks and micro holes, as well as identify visible damage to their structure and components, after seven- and fifteen-day reuse protocols. Method: cross-sectional study. Structural and morphological characteristics of a new N95/PFF2 mask were analyzed in comparison with N95/PFF2 masks (n=10) used in seven- and fifteen-day protocols, through visual inspection and scanning electron microscopy. Results: upon visual inspection, following the seven-day protocol, 40% and 60% of the N95/PFF2 masks showed, respectively, personal identification marks and external and internal dirt. Additionally, 20% exhibited loosening and/or tearing of the straps, while 100% showed some type of damage to the nose clips. In the fifteen-day protocol, all N95/PFF2 masks had dirt, loose straps and damaged nose clips, and 80% had folds. Electronic microscopy revealed an increase in pores and loosening in the weaves from seven days onwards, extending up to fifteen days, with the presence of micro holes and residues. Conclusion: the reuse of N95/PFF2 masks affects their structural and morphological integrity. It is crucial to carry out tests to measure the impact of this practice on the safety of health professionals. Objective N95PFF2 NPFF N95 PFF2 N PFF N95/PFF morphology porosity components fifteenday day protocols Method crosssectional cross sectional study n=10 n10 n 10 (n=10 Results sevenday protocol 40 60 respectively dirt Additionally 20 andor or 100 clips 80 folds onwards residues Conclusion professionals N95PFF N9 n=1 n1 1 (n=1 4 6 2 8 n= (n= (n

Abstract Background Neuronal ceroid lipofuscinoses (NCL) are a group of autosomal recessive, inherited, lysosomal, and neurodegenerative diseases that causes progressive dementia, seizures, movement disorders, language delay/regression, progressive visual failure, and early death. Neuronal ceroid lipofuscinosis type 2 (CLN2), caused by biallelic pathogenic variants of the TPP1 gene, is the only NCL with an approved targeted therapy. The laboratory diagnosis of CLN2 is established through highly specific tests, leading to diagnostic delays and eventually hampering the provision of specific treatment for patients with CLN2. Epilepsy is a common and clinically-identifiable feature among NCLs, and seizure onset is the main driver for families to seek medical care. Objective To evaluate the results of the Latin America Epilepsy and Genetics Program, an epilepsy gene panel, as a comprehensive tool for the investigation of CLN2 among other genetic causes of epilepsy. Methods A total of 1,284 patients with epilepsy without a specific cause who had at least 1 symptom associated with CLN2 were screened for variants in 160 genes associated with epilepsy or metabolic disorders presenting with epilepsy through an epilepsy gene panel. Results Variants of the TPP1 gene were identified in 25 individuals (1.9%), 21 of them with 2 variants. The 2 most frequently reported variants were p.Arg208* and p.Asp276Val, and 2 novel variants were detected in the present study: p.Leu308Pro and c.89 + 3G > C Intron 2. Conclusion The results suggest that these genetic panels can be very useful tools to confirm or exclude CLN2 diagnosis and, if confirmed, provide disease-specific treatment for the patients. (NCL recessive inherited lysosomal dementia seizures delayregression delay regression delay/regression failure death CLN2, CLN , (CLN2) TPP therapy tests clinicallyidentifiable clinically identifiable NCLs care Program panel 1284 284 1,28 16 1.9%, 19 1.9% 9 (1.9%) pArg208 pArg p Arg208 Arg p.Arg208 pAsp276Val pAspVal Asp276Val Asp Val p.Asp276Val study pLeu308Pro pLeuPro Leu308Pro Leu Pro c89 c 89 c.8 G confirmed diseasespecific disease (CLN2 128 28 1,2 1.9 (1.9% pArg20 Arg20 p.Arg20 pAsp AspVal pLeu LeuPro c8 8 c. (CLN 12 1, 1. (1.9 pArg2 Arg2 p.Arg2 (1. p.Arg (1 (

Resumo Antecedentes As lipofuscinoses ceroides neuronais (neuronal ceroid lipofuscinoses, NCLs, em inglês) são um grupo de doenças autossômicas recessivas, hereditárias, lisossomais e neurodegenerativas que causam demência progressiva, crises epiléticas, distúrbios de movimento, atraso/regressão da linguagem, deficiência visual progressiva e morte precoce. A lipofuscinose ceroide neuronal tipo 2 (neuronal ceroid lipofuscinosis type 2, CLN2, em inglês), causada por variantes patogênicas bialélicas do gene TPP1, é a única com terapia-alvo aprovada. O diagnóstico laboratorial é realizado por testes específicos, o que leva a atrasos diagnósticos e, consequentemente, prejudica a disponibilização de tratamento. A epilepsia é uma característica comum e clinicamente identificável entre as NCLs, e o início das convulsões é o principal motivo para as famílias buscarem atendimento médico. Objetivo Avaliar os resultados do Programa de Epilepsia e Genética da América Latina, um painel genético, como uma ferramenta abrangente para a investigação de CLN2 entre outras causas genéticas de epilepsia. Métodos Um total de 1.284 pacientes com epilepsia sem uma causa específica e que tinham pelo menos 1 sintoma associado à CLN2 foram rastreados em busca de variantes em 160 genes associados à epilepsia ou a distúrbios metabólicos que apresentam epilepsia, por meio de um painel genético. Resultados Variantes do gene TPP1 foram identificadas em 25 indivíduos (1,9%), sendo que ; 21 apresentavam duas variantes. As duas variantes mais frequentes foram p.Arg208* e p.Asp276Val, e duas variantes novas foram detectadas neste: p.Leu308Pro e c.89 + 3G > C Intron 2. Conclusão Os resultados sugerem que os painéis genéticos de epilepsia podem ser uma ferramenta útil para confirmar ou excluir o diagnóstico de CLN2 e, se confirmado, fornecer tratamento específico para os pacientes. NCLs inglês recessivas hereditárias epiléticas movimento atrasoregressão atraso regressão linguagem precoce CLN inglês, , TPP terapiaalvo terapia alvo aprovada específicos consequentemente médico Latina genético 1284 284 1.28 16 1,9%, 19 1,9% 9 (1,9%) pArg208 pArg p Arg208 Arg p.Arg208 pAsp276Val pAspVal Asp276Val Asp Val p.Asp276Val neste pLeu308Pro pLeuPro Leu308Pro Leu Pro c89 c 89 c.8 G confirmado 128 28 1.2 1,9 (1,9% pArg20 Arg20 p.Arg20 pAsp AspVal pLeu LeuPro c8 8 c. 12 1. 1, (1,9 pArg2 Arg2 p.Arg2 (1, p.Arg (1 (

Abstract Paper aims to propose the development of a Sales and Operations Planning (S&OP) diagnostic tool to assess the degree of implementation in the textile sector. Originality the delivery of a set of issues, with levels of maturity and visual management, allows for benchmarking and the identification of strengths and weaknesses, not only internally but also externally. Also, the comparison with other companies and the diagnosis of the integration of the internal sectors of a company around a shared vision of demand and delivery of goods to reduce the gaps between industrial and commercial areas. The tool developed compiles a set of questions to implement S&OP, such as integration between areas, the use of software, leftover raw materials, and finished products, the degree of assertiveness of consumer demand, and other criteria. Thus, it is possible to compare each company and make improvements. Research method the diagnostic tool was developed from proposals for other sectors, and a survey was later carried out with 16 textile companies to validate the developed tool. Eleven questions were developed with five levels of answers – from the basic to the advanced level. Main findings We created a ranking of the level of S&OP implementation in companies, contributing to the advancement of the maturity of the entire sector. The implementation in companies resulted in improved communication, reduced barriers between areas, and increased engagement of teams in the sales process and delivery of goods – factors that contribute to the success of key performance indicators (KPIs). Implications for theory and practice the initial gamble level of the production of goods following the forecast of demand in the textile companies in Brazil is, on average, 30%, which is worrying since this indicates low assertiveness. Thus, this study contributes to the evolution of the theme by structuring a diagnostic tool for managers with a deployment of more assertive strategies and communication. The analysis of theoretical work in various sectors allowed a comparison with practical results obtained in the textile sector. Furthermore, the tool serves as a guide to achieve the results demonstrated in the literature, such as increased profits and delivery accuracy, improved planning, and integration between areas, which directly lead to a more pleasant work environment. SOP S OP (S&OP sector issues management weaknesses externally Also areas software materials products criteria Thus improvements 1 communication KPIs. KPIs . (KPIs) average 30 30% Furthermore literature accuracy planning environment (KPIs 3

ABSTRACT This paper seeks to explain, through a police written media such as the Revista de los Carabineros de Chile (RCCh) in a given historical period (1946-1973), the different textual and visual representations that were elaborated concerning individuals and groups, described as abnormal, based on their virtual dangerousness for the authority, citizenship, and public morality. Employing a content analysis of the information and articles that appeared there, we examine the identities attributed to delinquents, criminals, alcoholics, and drug addicts; elaborated from the identification of behaviors and appearances recognizable by the community and from the survey of the cultural assumptions of the time. These constructions would show an adaptive character to changing ideological scenarios and moral concerns, being able to generate enunciative, discursive, and opinionated languages, in addition to defining, characterizing, and reinforcing, by opposition, the institutional identity of the Chilean uniformed police. explain RCCh (RCCh 19461973, 19461973 1946 1973 , (1946-1973) groups abnormal authority citizenship morality there delinquents criminals alcoholics addicts time concerns enunciative discursive languages defining characterizing reinforcing opposition 1946197 194 197 (1946-1973 194619 19 (1946-197 19461 1 (1946-19 (1946-1 (1946- (1946 (194 (19 (1 (

RESUMEN Este trabajo busca explicar, a través de un medio escrito policial como es la Revista de los Carabineros de Chile (RCCh) en un período histórico determinado (1946-1973), las distintas representaciones textuales y visuales que se elaboraron respecto de personas y grupos, adjetivados como anormales, a partir de su virtual peligrosidad para la autoridad, la ciudadanía y la moralidad pública. Mediante un análisis de contenido de las informaciones y artículos allí aparecidos, se examinan las identidades atribuidas a delincuentes, criminales, alcohólicos y toxicómanos, elaboradas a partir de la identificación de conductas y apariencias reconocibles por la colectividad y del relevamiento de los supuestos culturales de época. Dichas construcciones mostrarían un carácter adaptativo a escenarios ideológicos y preocupaciones morales cambiantes, siendo capaces de generar lenguajes enunciativos, discursivos y opinantes, además de definir, caracterizar y reforzar, por oposición, la identidad institucional de la policía uniformada chilena. explicar RCCh (RCCh 19461973, 19461973 1946 1973 , (1946-1973) grupos anormales autoridad pública aparecidos delincuentes criminales toxicómanos época cambiantes enunciativos opinantes definir reforzar oposición chilena 1946197 194 197 (1946-1973 194619 19 (1946-197 19461 1 (1946-19 (1946-1 (1946- (1946 (194 (19 (1 (

ABSTRACT: The interpreters in Chilean Sign Language (ILSCh) constitute a resource for inclusion, eliminating the barriers of deaf students who use the visual-gestural modality to communicate. Chile has regulations that favor the participation of the ILSCh in different áreas, and this study focused on interpreters in the school context, considering that there is a lack of knowledge of the processes, implementation, results, achievements and employment situation. The questions of the study were: What is the current state of the ILSCh, its formative trajectories, its role and the challenges of its work? The general objective was to describe the figure of the ILSCh and the challenges it faces in its work performance in the school context, located in the Metropolitan and Valparaíso regions, Chile. The approach was qualitative, interpretative, phenomenographic, descriptive and transactional design, the sample intentional by criteria of 24 school level interpreters. The information collection techniques were: identification form, interview and focus group. The transcripts were analyzed with the Atlas TI software. The results show the diversity in the training, focused on the vocabulary of the language, with minimal lines of the educational context, lack of knowlegde of the role, requests for tasks outside their functions and work situations without regulation and diversity of leadership. ABSTRACT (ILSCh inclusion visualgestural visual gestural communicate áreas context processes implementation situation trajectories regions qualitative interpretative phenomenographic design 2 form group software training language leadership

RESUMEN: Los intérpretes en Lengua de Señas Chilena (ILSCh) constituyen un recurso para la inclusión, eliminando barreras de estudiantes sordos que manejan la modalidad visual-gestual para comunicarse. Chile tiene normativa que favorece la participación del ILSCh en distintos ámbitos, y este estudio se centró en los intérpretes en contexto escolar, considerando que existe un desconocimiento de los procesos, implementación, resultados, logros y situación laboral. Las interrogantes del estudio fueron: ¿cuál es el estado actual del ILSCh, las trayectorias formativas, el rol y los desafíos de su quehacer? El objetivo general fue describir la figura del ILSCh y los desafíos que enfrenta en su desempeño laboral en contexto escolar, situados en las regiones Metropolitana y Valparaíso, Chile. El enfoque fue cualitativo, interpretativo, diseño fenomenográfico, descriptivo y transeccional, la muestra intencionada por criterios de 24 intérpretes de nivel escolar. Las técnicas de recogida de información fueron: formulario de identificación, entrevista y grupo focal. Se analizaron las transcripciones con el software Atlas TI. Los resultados muestran la diversidad en la formación, centrada en el vocabulario de la lengua, con mínimas líneas del contexto educativo, desconocimiento del rol, solicitudes de tareas fuera de sus funciones y situaciones laborares sin regulación y diversidad de jefaturas. RESUMEN (ILSCh inclusión visualgestual visual gestual comunicarse ámbitos escolar procesos implementación fueron cuál formativas quehacer Valparaíso cualitativo interpretativo fenomenográfico transeccional 2 identificación focal TI formación lengua educativo jefaturas

BACKGROUND: This study evaluates the interface between expert multistakeholder engagement and the development of Advanced Diploma in Visual Impairment Studies (VIS). Additionally, the study validates the content included in the modules of this training programme for teachers of learners with visual impairment (VI AIM: The aim of the study was to anchor on one of the objectives of a broader main study, namely to establish a network of experts that could provide input in terms of suitable content to include in the VI qualification SETTING: The study setting was the University of Pretoria, South Africa METHODS: Snowball sampling was used to identify 56 stakeholders from different organisations working in or having interest in visual impairment field. Two-phase Participatory Reflection and Action (PRA)-guided workshops and focus groups were utilised to generate data. Subsequestly, member checking was conducted with the stakeholders during a follow-up workshop, validating results RESULTS: Stakeholder partnerships were identified as a prominent theme. Sub-themes included the identification of potential stakeholders, collaboration and networking, maintaining partnerships, and community outreach CONCLUSION: The establishment of networks with key stakeholders was found to be important, however, the necessary care had to be taken to continuously engage stakeholders in content reviews and efforts to accommodate learners with VI through learnerships and entrepreneurial developments CONTRIBUTION: Teachers feel ill-equipped to work with learners with VI. This article attempts to highlight the benefit of involving the perspectives of multiple stakeholders when developing a programme informing the learning, teaching and supporting system in schools of learners with VI