ABSTRACT Purpose: To evaluate the effect of upper eyelid ptosis repairwith Muller muscle-conjunctival resection on meibomian gland function and ocular surface parameters. Methods: Thirty-eight patients who underwent ptosis repair with Muller muscle-conjunctival resection were retrospectively reviewed. Meibomian gland loss, Ocular Surface Disease Index OXFORD score, meiboscore, and noninvasive keratograph break-up time were measured preoperatively and at 1st, 3rd, and 6th months postoperatively. Results: Noninvasive keratograph break-up time values decreased significantly at 1st and 3rd months postoperatively compared to the preoperative level, but were similar to the preoperative level at 6th months postoperatively (p<0.001 and p=0.628, respectively). Ocular surface disease index, OXFORD score, meibomian gland loss, and meiboscore values increased significantly in the 1st and 3rd postoperative months compared to the preoperative period, but these values decreased to preoperative levels in the 6th postoperative month (p<0.001 and p>0.05, respectively). Conclusion: There is a transient deterioration in meibography findings and OSDI score in the early postoperative period afterMuller muscle-conjunctival resection. Patients undergoing Muller muscle-conjunctival resection may require topical lubricants, especially in the first 3 postoperative months. Purpose muscleconjunctival muscle conjunctival parameters Methods Thirtyeight Thirty eight reviewed loss breakup break up st rd th Results p<0.001 p0001 p 0 001 (p<0.00 p0628 628 p=0.628 respectively. respectively . respectively) index p005 05 p>0.05 Conclusion lubricants p<0.00 p000 00 (p<0.0 p062 62 p=0.62 p00 p>0.0 p<0.0 (p<0. p06 6 p=0.6 p0 p>0. p<0. (p<0 p=0. p>0 p<0 (p< p=0 p> p< (p p=

Resumo Este artigo trata da repressão política exercida no Conselho Nacional de Pesquisas Científicas e Técnicas (CONICET) durante a última ditadura militar na Argentina e da primeira experiência de reparação dos arquivos de pessoal assassinado e/ou desaparecido que o CONICET iniciou recentemente. Além da revisão bibliográfica e documental, realizamos entrevistas com informantes-chave e construímos uma matriz com dados primários sobre as vítimas da repressão na organização com base em uma revisão detalhada de mais de 8.000 resoluções institucionais entre 1973 e 1983. A matriz chegou a um total de 2.843 casos, 78% dos quais corresponderam a expulsões forçadas (demissões em massa e pedidos de licença) e 21% a exonerações pela organização (exonerações, demissões e outras medidas). Os resultados obtidos nos permitem medir o impacto da ditadura na principal organização científica da Argentina, algo que não havia sido estudado anteriormente. (CONICET eou ou recentemente documental informanteschave informantes chave 8000 8 000 8.00 197 1983 2843 2 843 2.84 casos 78 licença 21 exonerações, (exonerações medidas. medidas . medidas) anteriormente 800 00 8.0 19 198 284 84 2.8 7 80 0 8. 1 28 2.

Résumé Cet article traite de la répression politique exercée au Conseil national de la recherche scientifique et technique (CONICET) lors de la dernière dictature militaire en Argentine et de la première expérience de réparation des archives du personnel assassiné et/ou disparu que le CONICET a récemment entamée. En plus de la révision bibliographique et documentaire, nous avons mené des entretiens avec des informateurs clés et construit une matrice avec des données primaires sur les victimes de la répression dans l’organisation sur la base d’une révision détaillée de plus de 8000 résolutions institutionnelles entre 1973 et 1983. La matrice a atteint un total de 2.843 cas, dont 78% ont été des expulsions forcées (licenciements massifs et demandes de congé) et 21% d’exemptions par l’organisation (révocation, licenciements et autres mesures). Les résultats obtenus nous permettent de mesurer l’impact de la dictature sur la principale organisation scientifique en Argentine, ce qui n’avait pas été étudié auparavant. (CONICET etou ou entamée documentaire lorganisation l dune d 800 197 1983 2843 2 843 2.84 cas 78 congé 21 dexemptions exemptions révocation, révocation (révocation mesures. mesures . mesures) limpact impact navait n avait auparavant 80 19 198 284 84 2.8 7 8 1 28 2.

Abstract This paper deals with the political repression carried out at the National Council for Scientific and Technical Research (CONICET) during the last military dictatorship in Argentina and the first experience to repair the files of murdered and/or disappeared people that CONICET began recently. In addition to the bibliographic and documental review, we interviewed key informants and built a matrix with primary data on the repression victims in the organization based on a detailed review of over 8,000 institutional resolutions between 1973 and 1983. The matrix arrived at a total of 2,843 cases, 78% of which corresponded to forced evictions (mass layoffs and license requests) and 21% to dismissals by the organization (dismissals, layoffs and other measures). The results obtained allow us to measure the impact of the dictatorship on Argentina’s main scientific organization, which had not been studied before. (CONICET andor or recently 8000 8 000 8,00 197 1983 2843 2 843 2,84 cases 78 mass requests 21 dismissals, (dismissals measures. measures . measures) Argentinas s before 800 00 8,0 19 198 284 84 2,8 7 80 0 8, 1 28 2,

Resumen Este trabajo aborda la represión política ejercida en el Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) durante la última Dictadura militar argentina y la primera experiencia de reparación de legajos del personal asesinado y/o desaparecido que el CONICET inició recientemente. Además de la revisión bibliográfica y documental; realizamos entrevistas a informantes claves y construimos una matriz con datos primarios sobre las víctimas de la represión en el organismo a partir de la revisión pormenorizada de más de 8000 resoluciones institucionales entre 1973 y 1983. La matriz alcanzó un total de 2843 casos, de los cuales el 78% corresponde a expulsiones forzadas (renuncias masivas y pedidos de licencias) y el 21% a exoneraciones por parte del organismo (bajas, cesantías y otras medidas). Los resultados obtenidos permiten dimensionar el impacto de la dictadura en el principal organismo científico argentino, algo que no había sido estudiado previamente. (CONICET yo o recientemente documental 800 197 1983 284 casos 78 renuncias licencias 21 bajas, bajas (bajas medidas. medidas . medidas) argentino previamente 80 19 198 28 7 2 8 1

Resumo Dada a porosidade inerente dos materiais cimentícios, as variações de temperatura perturbam o equilíbrio higrotérmico, influenciando, assim, a precisão das medições do coeficiente de dilatação térmica (CDT). Isso resulta em variações nas magnitudes de dilatação observadas, que dependem do teor de umidade do material. Muitas metodologias existentes para medir o CDT não controlam adequadamente a umidade ou consideram nuances procedurais, levando a imprecisões e, muitas vezes, exigindo equipamentos caros. Este estudo avalia duas metodologias para determinar o CDT de argamassas cimentícias, com foco na influência da umidade e no uso de equipamentos acessíveis. Entre as duas metodologias testadas, uma foi recomendada por sua maior precisão na determinação do CDT de uma amostra prismática de argamassa, medindo as variações de comprimento devido a mudanças de temperatura. Nesse método, a amostra é aquecida a 80ºC em uma umidade relativa fixa até que o equilíbrio higrotérmico seja alcançado, e as medições são realizadas durante o resfriamento para 22 ± 2°C. Ajustes são feitos para eliminar a influência dos pinos de referência, e o CDT é calculado utilizando regressão linear para correlacionar a deformação com a variação de temperatura. A metodologia demonstrou um desvio padrão de repetibilidade de 0,08×10−6/ºC, comparável à precisão da AASHTO T 336 (0,12×10−6/ºC) e superior à ASTM C 531 (1,62×10−6/ºC). A avaliação do CDT em níveis de umidade de 50%, 75%, 98% e saturado revelou um comportamento parabólico, com um CDT máximo próximo a 75% de umidade relativa, alinhando-se com a literatura existente. Esta metodologia oferece uma abordagem promissora para avaliar o CDT de argamassas, particularmente as argamassas de reparo expostas às condições ambientais, enfatizando a importância da compatibilidade entre a argamassa de reparo e o substrato em diferentes níveis de umidade. cimentícios influenciando assim CDT. . (CDT) observadas material procedurais vezes caros cimentícias acessíveis testadas método ºC alcançado 2 2C 2°C referência 008106ºC 0 08 10 6 0,08×10−6/ºC 33 0,12×10−6/ºC 012106ºC 12 (0,12×10−6/ºC 53 1,62×10−6/ºC. 162106ºC 1,62×10−6/ºC 1 62 (1,62×10−6/ºC) 50 50% 75 98 parabólico alinhandose alinhando se existente ambientais (CDT 3 5 (1,62×10−6/ºC 7 9

Abstract Given the inherent porosity of cementitious materials, fluctuations in temperature disrupt the hygrothermal equilibrium, thereby influencing the accuracy of the coefficient of thermal expansion (CTE) measurements. This results in variations in the observed expansion magnitudes, which are contingent on the material's moisture content. Many existing methodologies for measuring CTE do not adequately control for moisture or consider procedural nuances, leading to inaccuracies and often necessitating expensive equipment. This study evaluates two methodologies for determining the CTE of cementitious mortars, focusing on the influence of moisture and the use of accessible equipment. Among the two methodologies tested, one was recommended for its higher precision in determining the CTE of a prismatic mortar sample by measuring length variations due to temperature changes. In this method, the sample is heated to 80ºC at a fixed relative humidity until hygrothermal equilibrium is reached, after which measurements are taken during cooling to 22 ± 2°C. Adjustments were made to eliminate the influence of studs, and the CTE is calculated using linear regression to correlate strain with temperature variation. The methodology demonstrated a repeatability standard deviation of 0.08×10−6/ºC, comparable to the precision of AASHTO T 336 (0.12×10−6/ºC) and superior to ASTM C 531 (1.62×10−6/ºC). Evaluating CTE at moisture levels of 50%, 75%, 98%, and saturation revealed a parabolic behavior, with a maximum CTE near 75% relative humidity, aligning with existing literature. This methodology offers a promising approach for assessing the CTE of mortars, particularly those exposed to environmental conditions, emphasizing the importance of compatibility between repair mortar and substrate across different moisture levels. materials (CTE magnitudes material s content nuances equipment mortars tested changes method ºC reached 2 2C 2°C studs variation 008106ºC 0 08 10 6 0.08×10−6/ºC 33 0.12×10−6/ºC 012106ºC 12 (0.12×10−6/ºC 53 1.62×10−6/ºC. 162106ºC 1.62×10−6/ºC . 1 62 (1.62×10−6/ºC) 50 50% 75 98 98% behavior literature conditions 3 5 (1.62×10−6/ºC 7 9

Resumen Introducción: La ansiedad, la depresión y el estrés son cada vez más frecuentes, especialmente desde la crisis sanitaria del COVID-19. El objetivo principal de este artículo es analizar el poder predictivo de la edad, el sexo, la inteligencia emocional y la resiliencia respecto a los síntomas ansiosos, depresivos y el estrés en una muestra de población española. Método: Un total de 427 participantes españoles, con edades entre 18 y 83 años, fueron evaluados mediante instrumentos de autoinforme (TMMS-24; BRCS; BASS-21). Se utilizan modelos de regresión jerárquica (RLJ) y metodologías no lineales (modelos de análisis comparativo cualitativo o QCA). Resultados: Los RLJ mostraron que la atención emocional, la claridad y la reparación predecían significativamente la ansiedad, la depresión y el estrés. El género también desempeñó un papel significativo, ya que las mujeres mostraron mayores niveles de ansiedad y estrés. La edad y la resiliencia no fueron predictores significativos en la HRM. Sin embargo, los modelos QCA revelaron otras interacciones: la depresión estaba relacionada con una menor edad, la atención emocional alta y la claridad y la reparación emocional bajas. La ansiedad elevada se predijo por ser mujer, joven, con baja regulación emocional y alta atención emocional. El estrés elevado se asoció con ser mujer, tener baja resiliencia y una atención emocional elevada. Por el contrario, los niveles bajos de depresión, ansiedad y estrés se asociaron de forma consistente con una alta resiliencia y claridad y regulación emocional. Conclusiones: Consideramos que estos resultados son de gran interés para profundizar en el conocimiento de la interacción entre las variables objeto de estudio. De este modo, será posible diseñar intervenciones más eficaces que se beneficien del máximo conocimiento sobre el papel de estas variables.

Abstract Introduction: Anxiety, depression and stress are becoming more and more frequent, especially since the COVID-19 health crisis. The main objective of this study was to analyse the predictive power of age, gender, emotional intelligence, and resilience with respect to anxiety, depression, and stress-related symptoms in a Spanish population sample. Method: A total of 427 Spanish participants, between 18 and 83 years of age, were assessed through self-report instruments (TMMS-24; BRCS; BASS-21). Hierarchical regression models (HRM) and non-linear methodologies (qualitative comparative analysis or QCA models) are used. Results: The HRM showed that emotional attention, clarity, and repair significantly predicted anxiety, depression, and stress. Gender also played a significant role, with women showing higher levels of anxiety and stress. Age and resilience were not significant predictors in the HRM. However, the QCA models revealed more nuanced interactions: high depression was linked to young age, high emotional attention, and low emotional clarity and repair. High anxiety was predicted by being female, young, with low emotional regulation, and high emotional attention. High stress was associated with being female, low resilience, and high emotional attention. Conversely, low levels of depression, anxiety, and stress were consistently associated with high resilience and emotional clarity and regulation. Conclusions: We consider these results to be of great interest for gaining a deeper understanding of the interaction between the variables under study. In this way, it will be possible to design more effective interventions that benefit from the maximum knowledge regarding the role of these variables.

Abstract: In architecture, microorganisms can act as heroes or villains. However, research on microorganisms has been delegated to engineering sciences and is usually conducted in parallel with architecture. This study analyzes scientific advances in biomaterials, including microorganisms that benefit materials and microorganisms that degrade buildings. The methodology consisted of a literature review, followed by a classification and description of the microorganisms to facilitate the analysis of the findings. The results revealed that some microorganisms provide materials with positive characteristics, such as greater durability, self-repair, increased compression and absorption, and most importantly, environmental sustainability. During destructive processes, microorganisms primarily affect heritage buildings because of their destructive properties. The biodegradation of buildings can be slowed, delayed, or inhibited by microorganisms; therefore, this analysis can provide an opportunity to advance materials research.

Resumen: En arquitectura, los microorganismos tienen la doble capacidad de comportarse como héroes o villanos. Sin embargo, la investigación sobre microorganismos se ha delegado a las ciencias de la ingeniería y se suelen llevar de forma paralela a la arquitectura. Este artículo hace una revisión documental y un análisis de los avances científicos más recientes en biomateriales, incluyendo los microorganismos que benefician y los microorganismos que degradan las construcciones. La metodología consiste en una revisión documental en bases de datos en inglés y español, para sistematizar hallazgos y hacer una clasificación de microorganismos. Los resultados revelan que algunos microorganismos brindan a los materiales características positivas como mayor durabilidad, autorreparación, incremento a la compresión o absorción, pero sobre todo favorecen la sostenibilidad ambiental. En los procesos destructivos, los microorganismos afectan principalmente las edificaciones patrimoniales por sus materiales y temporalidad, lo cual representa un desafío para la ciencia de los materiales ya que algunos microorganismos o sus compuestos pueden retardar, retrasar o inhibir el biodeterioro de los edificios.

Resumo Após a realização de reparos localizados, costuma-se observar o ressurgimento de pontos de corrosão na região adjacente à área reparada, situação usualmente denominada ânodo incipiente. Embora tenham sido feitas diversas pesquisas a respeito do tema, ainda restam controversos aspectos em relação às suas causas, localização e progressão no tempo. Com objetivo de investigar essas lacunas no conhecimento, moldaram-se amostras com substrato contaminado por cloretos não reparadas e reparadas com argamassa de reparo contendo substituição de ligante por sílica de casca de arroz (SCA) nos teores de 0%, 10% e 20%. Em seguida, realizaram-se aferições das variáveis eletroquímicas de densidade e potencial de corrosão, bem como a inspeção destrutiva de parte das amostras. Após as aferições, observou-se aumento nas densidades de corrosão após o reparo, na interface substrato-reparo. Na inspeção destrutiva, também foi constatada deterioração significativa na interface reparo-substrato, bem como em algumas regiões no interior do substrato. Em relação ao efeito da substituição de ligante por SCA, não foi identificada redução relevante do ânodo incipiente nas argamassas com 10% e 20% de SCA. Por outro lado, notou-se possível redução da capacidade de passivação da argamassa com teor de 20% de SCA. localizados costumase costuma se reparada tema causas tempo conhecimento moldaramse moldaram SCA (SCA 0 0% 10 20 seguida realizaramse realizaram observouse observou substratoreparo. substratoreparo reparo. substrato-reparo reparosubstrato, reparosubstrato substrato, reparo-substrato lado notouse notou 1 2

Abstract After performing localized repairs, it is customary to observe the reappearance of corrosion points in the region adjacent to the repaired area, a situation usually called the incipient anode phenomenon. Although there are several studies have on the subject, there are still controversial aspects regarding its causes, location, and progression over time. To investigate these gaps in knowledge, samples were molded with unrepaired chloride-contaminated substrate and repaired with repair mortar containing 0%, 10%, and 20% binder replacement with rice husk ash (RHA). Then, measurements of the electrochemical variables of density and corrosion potential were carried out, as well as the destructive inspection of part of the samples. After the measurements, an increase in corrosion rates was observed after the repair, in the repair-substrate interface. In the destructive inspection, significant deterioration also was observed in the repair-substrate interface region, as well as inside the substrate. Regarding the effect of replacing the binder with RHA, no relevant reduction in the incipient anode was identified in the mortars with 10% and 20% RHA. On the other hand, a possible reduction in the passivation capacity of mortar with 20% RHA content was noted. repairs area phenomenon subject causes location time knowledge chloridecontaminated chloride contaminated 0 0% 10 20 . (RHA) Then out repairsubstrate hand noted 1 2 (RHA

Resumen Se estima que aproximadamente 1 de cada 100 na cidos vivos presenta una cardiopatía congénita (CC). El déficit cognitivo, las dificultades académicas y ano malías conductuales, en combinación, representan la morbilidad más común que afecta la calidad de vida en sobrevivientes con CC. La disfunción del desarrollo resulta de una interacción compleja entre factores espe cíficos del paciente como susceptibilidad genética, tipo de cardiopatía, desarrollo fetal y factores ambientales tales como eventos preoperatorios, técnicas de apoyo durante la reparación quirúrgica, eventos posoperatorios, estatus socioeconómico. Una evaluación integral del neurodesarrollo en todos los niños con CC es fundamen tal para identificar tempranamente cualquier necesidad de intervención y proporcionar el apoyo necesario para optimizar su desarrollo a largo plazo.

Abstract It is estimated that about 1 in 100 live births has a congenital heart disease (CHD). Cognitive deficit, ac ademic difficulties, and behavioral abnormalities, in combination, represent the most common morbidity affecting quality of life in survivors with CHD. Devel opmental dysfunction results from a complex interac tion between patient-specific factors such as genetic susceptibility, cardiac diagnosis, fetal development, and environmental factors such as preoperative events, sup portive techniques during surgical repair, postoperative events, socioeconomic status. A comprehensive neuro developmental assessment in all children with CHD is critical to identify any need for intervention early and provide the support needed to optimize their long-term development.

SUMMARY: The objective of this study was to investigate the effects of different oral root canal filling materials on the expression of inflammatory factors and protease related molecules in gingival crevicular fluid (GCF). A total of 90 patients with posterior tooth defects who underwent root canal therapy in our hospital were selected. They were divided into an observation group (group A) and a control group (group B) based on different root canal filling materials, with 45 teeth in each group. The group A patients were repaired with fiber post, composite resin combined with zirconia ceramic crown, while the group B patients were repaired with metal post core combined with metal ceramic crown. The clinical effect, periodontal index, restoration success rate, mastication efficiency, periodontal index, restoration effect, and the levels of GCF and Alkaline phosphatase (ALP) before and after restoration were compared between the two groups. The clinical efficacy of the group A was better than that of the group B patients. The success rate of repair and chewing efficiency in the group A were higher than those in the group B. The completeness rate, color matching rate, edge fit rate, edge coloring qualification rate, and gingival qualification rate of the group A patients were higher than those of the group B patients. After repair, the levels of GCF and ALP in both groups of patients were higher than before repair, and the group B was raised than the group A. The PLI, GI, and SBI indices of the group A patients were reduced than those of the group B patients. The application of fiber post, composite resin combined with zirconia porcelain crown restoration in patients with posterior tooth defects after root canal treatment can improve the success rate, chewing efficiency, and restoration effect, with little impact on changes in GCF and ALP levels in the body.

RESUMEN: El objetivo de este estudio fue investigar los efectos de diferentes materiales de obturación del canal radicular sobre la expresión de factores inflamatorios y moléculas relacionadas con proteasas en el fluido crevicular gingival (GCF). Se seleccionaron un total de 90 pacientes con defectos de los dientes posteriores que se sometieron a tratamiento de canal en nuestro hospital. Se dividieron en un grupo de observación (grupo A) y un grupo control (grupo B) basado en diferentes materiales de obturación del canal radicular, con 45 dientes en cada grupo. Los dientes de los pacientes del grupo A fueron reparados con poste de fibra, resina compuesta combinada con corona de cerámica de circonio, mientras que los dientes de los pacientes del grupo B fueron reparados con núcleo de poste de metal combinado con corona de cerámica de metal. Se compararon en los dos grupos el efecto clínico, el índice periodontal, la tasa de éxito de la restauración, la eficiencia de la masticación, el índice periodontal, el efecto de la restauración y los niveles de GCF y fosfatasa alcalina (ALP) antes y después de la restauración. La eficacia clínica del grupo A fue mejor que la de los pacientes del grupo B. La tasa de éxito de la reparación y la eficiencia de la masticación en el grupo A fueron mayores que las del grupo B. La tasa de integridad, la tasa de coincidencia de colores, la tasa de ajuste de los bordes, la tasa de calificación de la coloración de los bordes y la tasa de calificación gingival de los pacientes del grupo A fueron mayores que las de los pacientes del grupo B. Después de la reparación, los niveles de GCF y ALP en ambos grupos de pacientes fueron más altos que antes de la reparación, y el grupo B aumentó más que el grupo A. Los índices PLI, GI y SBI de los pacientes del grupo A fueron más reducidos que los pacientes del grupo B. La aplicación de poste de fibra, resina compuesta combinada con restauración de corona de porcelana de circonio en pacientes con defectos de dientes posteriores después del tratamiento de canal puede mejorar la tasa de éxito, la eficiencia de la masticación y el efecto de la restauración, con poco impacto en los cambios en los niveles de GCF y ALP en el cuerpo.

Abstract The quarry-workshops are ancient lithic landscapes that are socially significant and traditional. The aim of this work was to analyze the technological activities and the persistent use of space in a quarry-workshop landscape in Antofagasta de la Sierra (Catamarca province, Argentina). For this purpose, techno-typological studies of lithic assemblages sampled in different sectors of the quarry-workshop landscape were carried out, together with an analysis of differential stages of eolian abrasion. The quarry-workshop landscape has activity areas under open sky and repair where core reduction, blank extraction and tool knapping were carried out. The presence of techno-technological diagnostic tools (e.g., bifaces, bifacial thinning flakes, preforms and projectile points) indicated the activities of hunter-gatherer groups that occupied the region in different time periods. On the other hand, the information from the different stages of eolian abrasion allowed a chronological approach to the knapping events that gave rise to this ancient landscape. In addition, the analysis of the differential stages of abrasion made it possible to recognize cases of artifact reclamation and the reuse of task spaces in a persistent way. In sum, the data recovered from the analysis of the lithic assemblages made it possible to confirm the continuous procurement of raw materials and the sustained use of space at different moments of the local time sequence. In fact, the conformation of this ancient social landscape occurred continuously from the early Holocene and early middle Holocene.

Resumen Las canteras-taller conforman paisajes líticos antiguos que son socialmente significativos y tradicionales. El objetivo de este trabajo fue analizar las actividades tecnológicas y el uso persistente del espacio en un paisaje de canteras-taller de Antofagasta de la Sierra (provincia de Catamarca, Argentina). Para tal fin se llevaron a cabo estudios tecno-tipológicos de conjuntos líticos muestreados en diferentes sectores del paisaje de canteras-taller, junto a un análisis de estadios diferenciales de abrasión eólica. El paisaje de canteras-taller cuenta con áreas de actividad a cielo abierto y bajo reparo donde se realizaron tareas de reducción de núcleos, extracción de formas-base y formatización de instrumentos. La presencia de artefactos tecno-tipológicamente diagnósticos (por ejemplo, bifaces, lascas de adelgazamiento bifacial, preformas y puntas de proyectil) dio cuenta de actividades de grupos cazadores-recolectores que ocuparon la región en diferentes lapsos temporales. Por su parte, la información reunida de los distintos estadios de abrasión eólica permitió efectuar una aproximación cronológica relativa a los eventos de talla que dieron origen a este antiguo paisaje. Además, el análisis de los estadios diferenciales de abrasión posibilitó reconocer casos de reclamación de artefactos y la reutilización de espacios de tareas de manera persistente. En suma, los datos recobrados del análisis de los conjuntos líticos posibilitaron constatar el aprovisionamiento continuo de materias primas y el uso permanente del espacio en diferentes momentos de la secuencia temporal local. En efecto, la conformación de este antiguo paisaje social se dio de manera sostenida desde el Holoceno temprano e inicios del Holoceno medio.

Resumen Se presenta el caso clínico de una mujer de 53 años diagnosticada con una hernia de Bochdalek derecha complicada con oclusión intestinal. Este tipo de hernias diafragmáticas son raras, especialmente las localizadas en lado derecho, pero constituyen aquellas no hiatales más frecuentes. El diagnóstico se centró en la tomografía computarizada de tórax y abdomen, y la reparación se realizó mediante una malla de polipropileno. La evolución fue favorable, sin complicaciones asociadas al procedimiento.

Abstract The clinical case of a 53-year-old woman diagnosed with a right Bochdalek hernia complicated by intestinal obstruction is presented. This type of diaphragmatic her nia is rare, especially those located on the right side, but is the most common non-hiatal hernia. Her diagnosis focused on the computed tomography of the chest and abdomen and the repair was performed using a lapa roscopic approach. A primary closure was carried out associated with the placement of polypropylene mesh. Her evolution was favorable, with no complications as sociated with the procedure.

For a long period of time, what is termed scientific knowledge and discoveries have constantly ignored the existence of indigenous practices and knowledge. Until recently, indigenous knowledge systems (IKS) were not acknowledged when it comes to responding to the ailing world. IKS includes information created inside inborn social orders, autonomous of, and earlier to, the appearance of the cutting-edge logical information framework. It can relate to issues such as conserving nature, food production, forestry development and medicine, to mention a few. The purpose of the article is to discuss the importance of the integration of IKS and culture into climate change adaptation. This article makes the case that scientific interventions among the impoverished in rural developing nations are viewed as foreign and are thus not accepted by the local populace. Consequently, the scientific approach by development experts, and the complex nature of climate change and its understanding, has had no impact on people's adaptation in rural areas, where most of the people still rely on IKS to survive. This theoretical article focuses on the implications of IKS for climate change adaptation. The question the article intends to answer is, with the advent of climate change in recent years, how are rural communities coping with its impact? How is the scientific understanding of climate change with its complexities filtering down to the indigenous communities' coping and adaptation activities? The article's conclusion demystifies the notion that the impact of climate change might be mitigated, and repair achieved solely by scientifically developed measures against it. The article intends to contribute towards building knowledge that acknowledges the importance of different sources of interventions towards addressing climate change. It is important for the current and future professoriate to look beyond the conventional understanding of dealing with challenges such as climate change that the world is facing.

SUMMARY OBJECTIVE: The objective of this study was to analyze the genetic alterations of tumors within the scope of the homologous recombination deficiency gene panel in patients diagnosed with synchronous endometrial ovarian cancer who have been followed for over 5 years using next-generation sequencing. METHODS: DNA was isolated from the patient’s formalin-fixed, paraffin-embedded tissue blocks. Next-generation sequencing was performed using the Illumina capture-based sequencing method. Samples were sequenced using the Sophia HR Solution DNA Kit. RESULTS: Seven patients were included in this study. The ratios of likely pathogenic (LP)/pathogenic (P) somatic mutations in ATM (serine/threonine kinase or Ataxia-telangiectasia mutated gene), BRCA2 (breast cancer type 2 susceptibility gene), BARD1 (BRCA1 associated RING domain 1), TP53 (tumor protein p53), BIRP1 (BRCA1-interacting helicase 1 gene), PALB2 (partner and localizer of BRCA2), and CHECK2 were 21 (48.8%), 8 (18.6%), 5 (11.6%), 3 (6.9%), 2 (4.6%), 2 (4.6%), and 2 (4.6%), respectively, in endometrium, and the ratios of somatic mutations in ATM, BRCA2, TP53, BARD1, RAD54L (DNA repair/recombination protein like), BIRP1, and RAD51D (RAD51 recombinase paralog D) were 24 (60%), 6 (15%), 5 (12.5%), 2 (5%), 2 (5%), 1 (2.5%), and 1 (2.5%), respectively, in ovary. In endometrioid-synchronous endometrial ovarian cancer cases, P/LP mutations were observed in ATM and CHECK2 genes in endometrium and ATM, BRCA2, and TP53 genes in ovary. In two non-endometrioid-synchronous endometrial ovarian cancer cases, CHEK2 (checkpoint kinase 2) mutations were observed in endometrium and ATM and TP53 mutations in ovary, whereas in one case, P/LP mutations in ATM and TP53 genes were common in both tissues. CONCLUSION: Pathogenic variations confirming the diagnosis of synchronous endometrial ovarian cancer with genetic alterations were identified in all but one case. ATM gene mutation emerged as the most common alteration and has a potential association with a favorable prognosis. OBJECTIVE nextgeneration next generation METHODS patient s formalinfixed, formalinfixed formalin fixed, fixed formalin-fixed paraffinembedded paraffin embedded blocks Nextgeneration Next capturebased capture based method Kit RESULTS LP/pathogenic LPpathogenic LP /pathogenic P (P serine/threonine serinethreonine serine threonine Ataxiatelangiectasia Ataxia telangiectasia gene, , gene) BRCA breast BARD BRCA1 (BRCA 1, 1) TP TP5 tumor p53, p53 p p53) BIRP BRCA1interacting BRCAinteracting interacting PALB partner BRCA2) CHECK 48.8%, 488 48.8% 48 (48.8%) 18.6%, 186 18.6% 18 (18.6%) 11.6%, 116 11.6% 11 (11.6%) 6.9%, 69 6.9% 9 (6.9%) 4.6%, 46 4.6% 4 (4.6%) respectively RADL RAD L repairrecombination repair like, like like) RADD D RAD51 (RAD5 60%, 60 60% (60%) 15%, 15 15% (15%) 12.5%, 125 12.5% 12 (12.5%) 5%, 5% (5%) 2.5%, 25 2.5% (2.5%) ovary endometrioidsynchronous endometrioid cases PLP nonendometrioidsynchronous non CHEK checkpoint case tissues CONCLUSION prognosis p5 48.8 (48.8% 18.6 (18.6% 11.6 (11.6% 6.9 (6.9% 4.6 (4.6% RAD5 (RAD (60% (15% 12.5 (12.5% (5% 2.5 (2.5% 48. (48.8 18. (18.6 11. (11.6 6. (6.9 4. (4.6 (60 (15 12. (12.5 (5 2. (2.5 (48. (18. (11. (6. (4. (6 (1 (12. ( (2. (48 (18 (11 (4 (12 (2

Resumo O artigo explora a complexidade e as incertezas atuais sobre a covid longa, uma entidade nosológica emergente pós-covid-19, com contornos imprecisos e caracterizada por sintomas imprevisíveis e persistentes. Baseado em relatos de pessoas afetadas e equilibrando a revisão da literatura médica e jornalística sobre o tema, a história da ciência e a etnografia em saúde, o trabalho descreve e analisa as políticas de reconhecimento e de cuidado da doença em um contexto de injustiça epistêmica. O artigo contesta as representações da covid longa como uma condição meramente transitória, argumentando que, diferentemente das promessas de plena recuperação, o que tem ganhado forma é emergência de uma nova pessoa cuja biografia passa a ser reescrita com a covid longa. Para essas pessoas, o reconhecimento pleno da covid longa como uma entidade patológica distinta, aliado à validação de seu conhecimento experimental, significa mais do que simplesmente abrir possibilidades concretas para alívio do sofrimento físico e mental. Isso também representa justiça, reparação e um passo adiante na reconstrução de suas vidas. póscovid19, póscovid19 póscovid pós 19, 19 pós-covid-19 persistentes tema saúde epistêmica transitória recuperação distinta experimental mental justiça vidas póscovid1 1 pós-covid-1 pós-covid- pós-covid

Abstract The article explores the complexity and current uncertainties concerning long COVID, an emerging nosological entity with vague contours and characterised by unpredictable and persistent symptoms and absence of ‘objective diagnosis’. Based on accounts of the affected individuals and balancing the review of medical and journalistic literature on the subject, historical approach and ethnography, this work describes and analyses the policies of recognition and care of this condition in a context of epistemic injustice. The article contests the representations of long COVID as a merely transient disorder arguing that, unlike the promises of full recovery, what is taking shape is the emergence of a new individual whose biography is being rewritten by long COVID. For these people, full recognition of long COVID as a distinct pathological entity, coupled with the validation of their experimental knowledge, means more than merely opening concrete possibilities for relief from physical and mental suffering. It also represents justice, repair, and a further step towards the reconstruction of their lives. objective diagnosis. diagnosis . diagnosis’ subject ethnography injustice that recovery people knowledge suffering justice repair lives

RESUMEN Mantener la vitalidad pulpar y su función es una de las prioridades de los medicamentos utilizados en la terapia pulpar con la finalidad de preservar la integridad del diente. Objetivo El objetivo de este estudio fue evaluar la respuesta inflamatoria y la reparación del puente dentinario con dos biocerámicas. Materiales y Métodos: Se realizó un estudio experimental in vivo en 12 ratas Wistar formando dos grupos de estudio (n = 6), en las que se realizaron pulpotomías. Posterior a 15, 45 y 90 días, se obtuvieron segmentos de los maxilares y se prepararon los especímenes para análisis histológicos y cortes microtomográficos. Las Unidades Hounsfield (UH) se cuantificaron. Resultados El análisis microtomográfico mostró un incremento en la mineralización después de 90 días con Neo MTA comparado con Biodentine. No existió diferencia significativa (p >0.05) entre las UH posterior a 15 y 45 días, sin embargo, a los 90 días hubo diferencia significativa (p <0.05) entre Biodentine y Neo MTA. A los 45 y 90 días los molares tratados con Neo MTA mostraron la formación de tejido mineralizado en el orificio comunicados. Los molares tratados con Biodentine mostraron la formacion de tejido mineralizado, a los 45 dias se observó un puente de dentina en el sitio expuestos y una cobertura total de la exposición pulpar y una matriz de dentina mineralizada a los 90 días. Conclusiones Biodentine y Neo MTA inducen la formación del puente dentinario reparador posterior a 45 días con infiltrado de células inflamatorias.

ABSTRACT Maintaining pulp vitality and function is a priority of the medicaments employed in pulp therapy to preserve tooth integrity. Aim This study evaluated inflammatory response and reparative dentin bridge formation after direct pulp capping with two different bioceramics. Materials and Method This was an in vivo controlled experimental study on 12 male Wistar rats. Pulpotomies were performed and the exposed pulps were capped with Biodentine or Neo MTA. After 15, 45 and 90 days, maxillary segments were obtained and prepared for histologic analysis and Micro-CT. Hounsfield Units (HU) were quantified. Results Micro-CT analysis showed greater mineralization at 90 days with Neo MTA than with Biodentine. HU did not differ significantly (p >0.05) between molars treated with Biodentine and Neo MTA at 15 and 45 days, but at 90 days, there was statistically significant difference (p <0.05) between them. Reparative dentin was observed near the pulp exposure and canal orifice with both bioceramics. At 45 and 90 days, molars treated with Neo MTA showed mineralized tissue filling the canal orifice. Molars treated with Biodentine showed mineralized tissue and dentin bridge at the site of exposure at 45 days, and total pulp exposure coverage and mineralized dentin matrix at 90 days. Conclusions Biodentine and Neo MTA induce the formation of reparative dentin bridge after 45 days with inflammatory cell infiltrate.

ABSTRACT This study proposes an innovative and sustainable solution for road repair using a variant of cold asphalt concrete obtained by combining petroleum sludges, serpentinites, and vitrified clay shales from the Moa region. This proposal aims to manage industrial waste more efficiently and reduce dependence on conventional construction material resources, thereby promoting sustainability in road repair.

RESUMEN Este estudio propone una innovadora y sostenible solución para la reparación de carreteras con una variante de hormigón asfáltico en frío obtenido mediante la combinación de lodos petrolizados, serpentinitas y tobas vitroclásticas de la región de Moa. Esta propuesta apunta a gestionar de manera más eficiente los residuos industriales y a reducir la dependencia de los recursos convencionales de materiales de la construcción, promoviendo así la sostenibilidad en la reparación de carreteras.