This paper presents the stages of an acceleration program focused on chemical technologies. We demonstrate how this initiative contributes to the creation of new businesses, startups, and technology licensing from research developed at Brazilian universities. The case of the program Escale-se is discussed. There were 66 technologies submitted, and 14 were selected for the pre-acceleration phase. In this phase, various contents were worked on, such as creating a business model and aspects of scaling hard-science technologies. Teams were evaluated by panels with market specialists, and 6 were selected for the second phase: pre-scaling/proof of concept. Here, proponents were encouraged to validate the business model by connecting with potential clients and partners, as well as planning the development and testing of the product in a relevant environment. Finally, one team was classified for the last stage: scaling/go-to-market - where they received R$ 100,000.00 to scale up their technology and create strategies for raising investments. Four of the fourteen technologies selected for the program opened National Register of Legal Entities (CNPJ) and raised approximately R$ 4.5 M in investments from different sources. These results demonstrate that the methodology contributed to the entrepreneurial development of participating researchers and the raising of funds for the businesses created. startups universities Escalese Escale se discussed submitted 1 preacceleration pre phase hardscience hard science specialists prescaling/proof prescalingproof scaling/proof proof concept Here partners environment Finally stage scaling/gotomarket scalinggotomarket scaling/go go R 10000000 100 000 00 100,000.0 CNPJ (CNPJ 45 4 5 4. sources created prescaling scalingproof gotomarket scalinggo 1000000 10 0 100,000. 100000 100,000 10000 100,00 1000 100,0 100,

RESUMO Objetivo: Verificar a utilização e identificar as vantagens dos métodos moleculares para diagnóstico de infecções congênitas no líquido cefalorraquidiano de neonatos. Fontes de dados: A revisão foi registrada na base PROSPERO (International Prospective Register of Systematic Reviews) sob CRD42021274210. A busca bibliográfica foi realizada nas bases de dados PubMed, Biblioteca Virtual em Saúde/ Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde (BVS/BIREME), Scopus, Web of Science, Excerpta Medica database (EMBASE), Cochrane, ProQuest, e EBSCOhost. A busca foi feita no período de agosto a outubro de 2021 e atualizada em dezembro de 2022, respeitando as orientações do Preferred Reporting Items for Systematic Reviews e Meta-Analyises (PRISMA). A sequência da seleção dos estudos foi: 1) Remoção de duplicatas; 2) Exame de títulos e resumos; 3) Recuperação dos textos completos potencialmente relevantes; e 4) Avaliação do texto completo conforme critérios de elegibilidade por dois autores independentes. O critério de inclusão considerou ensaios clínicos randomizados e não randomizados, estudos longitudinais, transversais, revisados por pares, estudos em humanos, publicados em inglês, espanhol, italiano e português, com recém-nascidos de até 28 dias que sofreram neuroinfecções congênitas pelos agentes toxoplasmose, rubéola, citomegalovírus, herpes simples (TORCH), e outros como Treponema pallidum, Zika, parvovírus B-19, varicela zoster, Epstein-Barr, e SARS-CoV-2, diagnosticadas por reação em cadeia de polimerase (PCR). Dois avaliadores extraíram as seguintes informações: autor, ano de publicação, nacionalidade, sujeitos, tipo de estudo, métodos, resultados e conclusão. Síntese dos dados: O patógeno mais estudado foi Herpes Simples. Muitos artigos relataram somente sintomas iniciais inespecíficos, motivando a coleta de líquido cefalorraquidiano e realização da PCR para investigação etiológica. Conclusões: Os métodos moleculares são eficazes para detectar o genoma do patógeno no líquido cefalorraquidiano, o que pode impactar na evolução clínica e no prognóstico neurológico. Objetivo neonatos International CRD42021274210 CRD PubMed LatinoAmericano Latino Americano BVS/BIREME, BVSBIREME BVS/BIREME , BVS BIREME (BVS/BIREME) Scopus Science EMBASE, EMBASE (EMBASE) Cochrane ProQuest EBSCOhost 202 2022 MetaAnalyises Meta Analyises PRISMA. PRISMA . (PRISMA) 1 duplicatas 2 resumos 3 relevantes 4 independentes longitudinais transversais pares humanos inglês espanhol português recémnascidos recém nascidos toxoplasmose rubéola citomegalovírus TORCH, TORCH (TORCH) pallidum Zika B19, B19 B 19, 19 B-19 zoster EpsteinBarr, EpsteinBarr Epstein Barr, Barr Epstein-Barr SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2, SARS-CoV-2 PCR. (PCR) informações autor publicação nacionalidade sujeitos estudo conclusão Simples inespecíficos etiológica Conclusões neurológico CRD4202127421 (BVS/BIREME (EMBASE 20 (PRISMA (TORCH B1 B-1 SARS-CoV- (PCR CRD420212742 B- SARS-CoV CRD42021274 CRD4202127 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

ABSTRACT Objective: To verify the use and identify advantages of molecular methods for congenital infections diagnosis in cerebrospinal fluid of neonates. Data source: The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), under CRD42021274210. The literature search was performed in databases: PubMed, Virtual Health Library/ Latin American and Caribbean Center on Health Sciences Information (VHL/BIREME), Scopus, Web of Science, Excerpta Medica database (EMBASE), Cochrane, ProQuest, and EBSCOhost. The search was carried out from August to October 2021 and updated in December 2022, respecting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The selection sequence was: 1) Duplicate title removal; 2) Examination of titles and abstracts; 3) Full-text retrieval of potentially relevant reports; and 4) Evaluation of the full text according to eligibility criteria by two independent authors. Inclusion criteria considered randomized and non-randomized control trials, longitudinal, cross-sectional, and peer-reviewed studies in humans, published in English, Spanish, Italian, and Portuguese, with newborns up to 28 days old who had congenital neuroinfections by toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH), and others such as Treponema pallidum, Zika, parvovirus B-19, varicella zoster, Epstein-Barr, and SARS-CoV2, diagnosed by polymerase chain reaction (PCR). Two evaluators extracted the following information: author, year of publication, nationality, subjects, study type, methods, results, and conclusion. Data synthesis: The most studied pathogen was herpes simplex. Several articles reported only nonspecific initial symptoms, motivating the collection of cerebrospinal fluid and performing PCR for etiological investigation. Conclusions: Molecular methods are effective to detect pathogen genomes in cerebrospinal fluid, which can impact clinical evolution and neurological prognosis. Objective neonates source PROSPERO, PROSPERO , (PROSPERO) CRD42021274210 CRD databases PubMed Library VHL/BIREME, VHLBIREME VHL/BIREME VHL BIREME (VHL/BIREME) Scopus Science EMBASE, EMBASE (EMBASE) Cochrane ProQuest EBSCOhost 202 2022 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines 1 removal 2 abstracts 3 Fulltext Full reports 4 authors nonrandomized non trials longitudinal crosssectional, crosssectional cross sectional, sectional cross-sectional peerreviewed peer reviewed humans English Spanish Italian Portuguese toxoplasmosis rubella cytomegalovirus TORCH, TORCH (TORCH) pallidum Zika B19, B19 B 19, 19 B-19 zoster EpsteinBarr, EpsteinBarr Epstein Barr, Barr Epstein-Barr SARSCoV2, SARSCoV2 SARSCoV SARS CoV2, CoV2 CoV SARS-CoV2 PCR. . (PCR) information author publication nationality subjects type results conclusion synthesis symptoms investigation Conclusions prognosis (PROSPERO CRD4202127421 (VHL/BIREME (EMBASE 20 (TORCH B1 B-1 SARS-CoV (PCR CRD420212742 B- CRD42021274 CRD4202127 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Comparar a presença de anticorpos neutralizantes contra o SARS-CoV-2 no leite materno e no sangue das lactantes vacinadas em relação àquelas não vacinadas. Fontes de dados: Foi efetuado registro no International Prospective Register of Systematic Reviews — PROSPERO (CRD42021287554) e foram seguidas as diretrizes do Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Foram elegíveis estudos de coorte, caso-controle e transversais que avaliaram anticorpos contra o SARS-CoV-2 no leite e no sangue de lactantes vacinadas e tiveram como grupo controle lactantes não vacinadas. Utilizaram-se os Descritores em Ciências da Saúde (DeCs), Medical Subject Heading (MeSH) e Emtree para as bases Biblioteca Virtual em Saúde (BVS), Medical Literature Analysis and Retrieval System Online (Medline/PubMed) e Embase, respectivamente. Na Web of Science e Scopus foi feita adaptação da estratégia. Não foram estabelecid as restrições quanto ao período de publicação e idioma. Síntese dos dados: As buscas identificaram 233 registros. Foram excluídos 128 duplicados e 101 fora dos critérios de inclusão, e quatro estudos de coorte foram elegíveis. As lactantes vacinadas com Pfizer-BioNTech e Moderna apresentaram anticorpos contra SARS-CoV-2 no sangue e no leite materno. Conclusões: As mulheres lactantes vacinadas apresentaram níveis mais elevados de imunoglobulina G (IgG) e A (IgA) no soro e no leite materno em comparação com as mulheres não vacinadas. Objetivo SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- dados CRD42021287554 CRD (CRD42021287554 MetaAnalysis Meta PRISMA. PRISMA . (PRISMA) casocontrole caso Utilizaramse Utilizaram se DeCs, DeCs , (DeCs) MeSH (MeSH BVS, BVS (BVS) Medline/PubMed MedlinePubMed Medline PubMed (Medline/PubMed Embase respectivamente estratégia idioma 23 registros 12 10 inclusão PfizerBioNTech Pfizer BioNTech Conclusões IgG (IgG IgA (IgA SARS-CoV CRD4202128755 (CRD4202128755 (PRISMA (DeCs (BVS 1 CRD420212875 (CRD420212875 CRD42021287 (CRD42021287 CRD4202128 (CRD4202128 CRD420212 (CRD420212 CRD42021 (CRD42021 CRD4202 (CRD4202 CRD420 (CRD420 CRD42 (CRD42 CRD4 (CRD4 (CRD

ABSTRACT Objective: To compare the presence of neutralizing antibodies against SARS-CoV-2 found in the breast milk and blood of vaccinated lactating women with those not vaccinated. Data source: The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021287554 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort, case-control, and cross-sectional studies that evaluated antibodies against SARS-CoV-2 in the milk and blood of vaccinated mothers and had as control group unvaccinated mothers were eligible. Health Sciences Descriptors (DeCs), Medical Subject Headings (MeSH) and Emtree descriptors were used for the Virtual Health Library (VHL), Medical Literature Analysis and Retrieval System Online (Medline/Pubmed), and Embase databases, respectively. In the Web of Science and Scopus, the strategy was adapted. No restrictions on the publication period and language were set. Data synthesis: The search identified 233 records, of which 128 duplicates and 101 papers that did not meet the inclusion criteria were excluded. Hence, four cohort studies were eligible. Nursing mothers vaccinated with the Pfizer-BioNTech and Moderna vaccines showed antibodies against SARS-CoV-2 in their blood and breast milk. Conclusions: Vaccinated lactating women had higher levels of immunoglobulin G (IgG) and A (IgA) in serum and breast milk than unvaccinated women. Objective SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- source PROSPERO (PROSPERO CRD CRD4202128755 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines Cohort casecontrol, casecontrol case control, case-control crosssectional cross sectional eligible DeCs, DeCs , (DeCs) MeSH (MeSH VHL, VHL (VHL) Medline/Pubmed, MedlinePubmed Medline/Pubmed Medline Pubmed (Medline/Pubmed) databases respectively Scopus adapted set synthesis 23 records 12 10 excluded Hence PfizerBioNTech Pfizer BioNTech Conclusions IgG (IgG IgA (IgA SARS-CoV CRD420212875 (DeCs (VHL (Medline/Pubmed 1 CRD42021287 CRD4202128 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

RESUMO Introdução/enquadramento/objetivos A produção de sal, sobretudo com métodos artesanais, não existe em todos os países, dadas as exigências climáticas e logísticas. Portugal apresenta alguma tradição nesse setor mas, ainda assim, a maioria dos profissionais a exercer na Saúde e Segurança Ocupacionais não tem experiência na área. Pretendeu-se com esta revisão resumir o que mais relevante e recente se publicou, de forma a melhorar a capacidade de atuação destes e a potenciar a produtividade, satisfação e bem-estar dos trabalhadores afetos. Metodologia Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023 nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo As salinas podem ser interiores (afastadas do mar, usando água subterrânea com elevado conteúdo em sal) ou litorais. As primeiras são mais escassas em Portugal e apenas existem entre Lisboa e Coimbra. Ao longo do tempo, no nosso país, a evaporação era realizada pelo fogo e sol. Esta última acredita-se que foi desenvolvida pelos romanos que, de certa forma, criaram a primeira versão das salinas. A nível nacional há evidência de produção de sal desde o final do Neolítico, mas aqui mais frequente com a utilização do fogo. Por toda a Europa tem existido um declínio da produção artesanal de sal, versus industrial, mesmo em salinas marítimas (sobretudo na costa noroeste de França e, em Portugal, na costa ocidental). A produção artesanal no nosso país é mais prevalente na zona da Figueira da Foz. O produto obtido via artesanal tem mais qualidade, nomeadamente a nível de sabor e nutricionalmente (via industrial o paladar é um pouco mais metálico). Portugal é um grande produtor e consumidor de sal tradicional. As caraterísticas climáticas adequam-se à produção, devido aos verões com temperaturas elevadas frequentes e ventos fortes e quentes. O sal nacional era e é consumido noutros países europeus, por apresentar qualidade superior, mesmo tendo um preço mais elevado. A produção depende do clima, nomeadamente a insolação (número de horas ao sol), precipitação, temperatura, nebulosidade e ventos (que condicionam a evaporação). Ou seja, esta é mais intensa e rápida se a temperatura do ar for mais elevada, tal como com mais ventos secos (que geralmente são mais frequentes no Verão); a baixa precipitação também é favorável. A produção de sal tem vindo a aumentar, até pelas crescentes necessidades industriais. Para ser usado nesta última situação, deverá estar no patamar de 100% de pureza. Discussão e Conclusões Não se encontrou bibliografia que fizesse referência à dimensão da saúde e segurança ocupacionais neste setor profissional. Em função de experiência teórica e prática dos autores, descrevem-se os fatores de riscos e riscos mais relevantes do setor: radiação ultravioleta e eventual cancro de pele, cataratas e outras lesões associadas; desconforto térmico e eventual maior sinistralidade associada a descoordenação motora, pior ajuste cardiovascular, bem como desorientação e capacidade de tomar decisões; cargas e/ou posturas forçadas/mantidas e eventuais lesões músculo-esqueléticas, surgimento/agravamento de patologia herniária e queda de objetos e ao mesmo nível e eventuais equimoses, lacerações cutâneas e/ou fraturas. Seria interessante conhecer melhor o panorama nacional deste setor, através de estudos que estratificassem hierarquicamente o risco, descrevendo ainda com rigor as doenças profissionais e acidentes associados, bem como medidas mais eficazes para atenuar essas questões.

ABSTRACT Introduction/framework/objectives Salt production, especially using artisanal methods, does not exist in all countries, given the climatic and logistical requirements. Portugal has some tradition in this sector, but even so, most professionals working in Occupational Health and Safety have no experience in the area. The aim of this review was to summarize the most relevant and recent publications, to improve their performance capacity and enhance the productivity, satisfaction and well-being of the workers involved. Methodology This is a Bibliographic Review, initiated through a search carried out in April 2023 in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content Salt pans can be inland (far from the sea, using groundwater with a high salt content) or coastal. The former are scarcer in Portugal and only exist between Lisbon and Coimbra. Over time, in our country, evaporation was carried out by fire and sun. The latter is believed to have been developed by the Romans who created the first version of salt flats. At national level there is evidence of salt production since the end of the Neolithic, but here more frequently with the use of fire. Throughout Europe there has been a decline in artisanal versus industrial salt production, even in sea salt pans (especially on the northwest coast of France and, in Portugal, on the western coasts). Artisanal production in our country is more prevalent in the Figueira da Foz area. The product obtained via artisanal production has better quality, particularly in terms of flavor and nutritionally (via industrial production the taste is more metallic). Portugal is a large producer and consumer of traditional salt. The climatic characteristics suit production, due to summers with frequent high temperatures and strong, hot winds. National salt was and is consumed in other European countries; for presenting superior quality, even though it is more expensive. Production depends on the climate, namely insolation (number of hours in the sun), precipitation, temperature, cloudiness and winds (which affect evaporation). In other words, this is more intense and faster if the air temperature is higher, such as with more dry winds (which are generally more frequent in summer); low precipitation is also favorable. Salt production has been increasing, due to growing industrial needs. To be used in this last situation, it must be at 100% purity. Discussion and Conclusions No bibliography was found that referred the dimension of occupational health and safety in this professional sector. Based on the authors' theoretical and practical experience, the most relevant risk factors and risks in the sector are described: ultraviolet radiation and possible skin cancer, cataracts and other associated injuries; thermal discomfort and eventual higher accident rates associated with motor incoordination, worse cardiovascular adjustment, as well as disorientation and ability to make decisions; forced/maintained loads and/or postures and possible musculoskeletal injuries, emergence/worsening of hernia pathology and falling objects at the same level and possible bruises, skin lacerations and/or fractures. It would be interesting to learn more about the national panorama of this sector, through studies that hierarchically stratify the risk, also accurately describing occupational illnesses and associated accidents, as well as more effective measures to mitigate these issues.

RESUMO Introdução/enquadramento/objetivos Ao longo dos últimos anos a generalidade dos países foi desenvolvendo normas relativas à diminuição dos locais onde continua a ser possível fumar, nomeadamente em contexto laboral. Pretendeu-se com esta revisão resumir o que de mais recente se publicou sobre o tema. Metodologia Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023 nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo O Tabagismo Passivo é definido como fumo de "segunda mão" que engloba uma mistura complexa de poluentes, permanecendo na poeira das superfícies locais onde se fumou, constituída pelos produtos tabágicos originais e os componentes originários pela respiração do consumidor direto, eventualmente reagindo a outros agentes presentes. Estes podem permanecer nas superfícies inertes, por vezes, por meses e a transmissão pode ocorrer pelo simples toque. Alguns investigadores estimam que existam neste contexto cerca de 4000 agentes químicos, dos quais 250 são tóxicos e 50 são inclusivamente carcinogénicos. O tabaco é uma das causas preveníveis de morte mundialmente e fator de risco modificável, por mecanismos que abarcam o dano de DNA, inflamação e stress oxidativo. Ele implica custos de saúde e de diminuição da produtividade laboral, em função das patologias associadas, nomeadamente cardiovascular, respiratória, oncológica, obstétrica e infeciosa. Discussão e Conclusões Ao longo das últimas décadas verificou-se, globalmente, uma diminuição ao Tabagismo Passivo, devido à introdução de normas cada vez mais restritivas em relação aos locais onde ainda é permitido fumar, na sociedade em geral e, obviamente, em contexto de trabalho também. Os artigos selecionados não realçaram muito o seguinte detalhe mas, criando-se áreas onde é permitido fumar na empresa, estas devem minimizar a exposição de todos os trabalhadores, tabagistas e, sobretudo, não fumadores. Seria desejável que os países/instituições onde as normas são menos restritivas e/ou cumpridas, tal se alterasse, de forma a todos os trabalhadores terem um ambiente laboral seguro. Para além disso, seria interessante perceber qual a opinião que os trabalhadores portugueses têm em relação a este tema, de que forma as normas são cumpridas nos seus locais de trabalho e quais as técnicas mais eficazes para obter mais sucesso neste contexto.

ABSTRACT Introduction/framework/objectives Over the last few years, most countries have developed standards relating to reducing the number of places where smoking continues to be possible, particularly in the workplace. This review was intended to summarize the most recent publications on the topic. Methodology This is a Bibliographic Review, initiated through a search carried out in April 2023 in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content Passive Smoking is defined as "second-hand" smoke that encompasses a complex mixture of pollutants, remaining in the dust on local surfaces where it was smoked, consisting of the original tobacco products and the components originating in the direct consumer's breath, eventually reacting to other agents gifts. These can remain on inert surfaces, sometimes for months and transmission can occur by simple touch. Some researchers estimate that there are around 4000 chemical agents in this context, of which 250 are toxic and 50 are even carcinogenic. Tobacco is one of the preventable causes of death worldwide and a modifiable risk factor, through mechanisms that include DNA damage, inflammation and oxidative stress. It involves health costs and reduced labor productivity, due to associated pathologies, namely cardiovascular, respiratory, oncological, obstetric and infectious diseases. Discussion and Conclusions Over the last few decades, there has been a global decrease in passive smoke, due to the introduction of increasingly restrictive standards in relation to places where smoking is still permitted, in society in general and, obviously, in the workplace as well. The selected articles did not highlight the following detail much but, by creating areas where smoking is permitted in the company, these should minimize the exposure of all workers, smokers and, above all, non-smokers. It would be desirable for countries/institutions where standards are less restrictive and/or enforced to change, so that all workers have a safe working environment. Furthermore, it would be interesting to understand what opinion Portuguese workers have regarding this topic, how standards are complied with in their workplaces and what are the most effective techniques to achieve greater success in this context.

RESUMO Introdução/enquadramento/objetivos A Esclerose Múltipla tem uma prevalência razoável e o diagnóstico faz-se geralmente em idade ativa, numa fase ainda exigente a nível profissional, altura essa onde geralmente também existem particularidades pessoais/familiares que necessitam de alguma dedicação. Para além disso, dada a incidência, diversidade e gravidade dos sintomas apresentados, com frequência surgem limitações que podem condicionar seriamente a capacidade de trabalho ou até levar ao desemprego. Será então desejável que os elementos a exercer em equipas de Saúde e Segurança Ocupacionais tenham alguns conhecimentos sobre o tema, de forma a melhor orientar o seu desempenho, salvaguardando os interesses de todos os envolvidos. Metodologia Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023, nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo É uma doença desmielinizante e auto-imune do Sistema Nervoso Central; carateriza-se por episódios recorrentes e intermitentes de inflamação, com destruição de mielina axonal, geralmente progressiva. Na maioria dos casos existe um ciclo de relapsos e remissões e sintomas de intensidade oscilante; a evolução é imprevisível. Causa sintomas autonómicos, visuais, motores e sensoriais; o que dificulta a vida quotidiana independente e o trabalho, tornando-se por vezes debilitante. É incurável e neurodegenerativa. A gravidade varia com as áreas neurológicas mais atingidas. À medida que a mielina se detiora, ela é substituída por cicatrizes de tecido anormal, com diferente consistência (rigidez, placas), o que perturba ainda mais a condução. Lesões nos lóbulos frontal e parietal geralmente resultam em alterações cognitivas e emocionais; na espinal medula, mais facilmente surgem problemas nos membros inferiores. Alterações no nervo ótico e lobo occipital podem originar alterações visuais. Trata-se da doença neurológica que mais limitações causa na população ativa jovem adulta. Dada a idade razoavelmente jovem do início de sintomas, irá ocorrer diminuição da qualidade de vida, mais significativa que noutras doenças crónicas. Discussão e Conclusões Ainda que a bibliografia não seja escassa, a enfase da grande maioria dos artigos não é dada à Saúde ou Segurança Ocupacionais. Seria relevante que algumas equipas a exercer em empresas grandes e com alguma incidência, avaliassem com detalhe os casos, descrevendo os principais problemas detetados, medidas propostas e avaliação posterior das mesmas, de forma a publicar não só o caminho, mas também as conclusões obtidas, para maior divulgação do assunto.

ABSTRACT Introduction/framework/objectives Multiple Sclerosis has a reasonable prevalence and the diagnosis is generally made at working age, at a stage that is still demanding on a professional level, a time when there are also generally personal/family particularities that require some dedication. Furthermore, given the incidence, diversity and severity of the symptoms presented, limitations often arise that can seriously affect the ability to work or even lead to unemployment. It is then desirable that the members working in Occupational Health and Safety teams have some knowledge on the subject, in order to better guide their performance, safeguarding the interests of everyone involved. Methodology This is a Bibliographic Review, initiated through a search carried out in April 2023, in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content It is a demyelinating and autoimmune disease of the Central Nervous System; it is characterized by recurrent and intermittent episodes of inflammation, with generally progressive destruction of axonal myelin. In most cases there is a cycle of relapses and remissions and symptoms of varying intensity; the evolution is unpredictable. Causes autonomic, visual, motor and sensory symptoms; which makes independent daily living and the ability to work difficult; sometimes becoming debilitating. It is incurable and neurodegenerative. The severity varies depending on the neurological areas most affected. The function of myelin is to facilitate conduction at the level of axons; with changes in this, the electrical impulses that coordinate mental and physical functions become less effective. As myelin deteriorates, it is replaced by scars of abnormal tissue, with different consistency (stiffness, plaques), which further disrupts conduction. Injuries to the frontal and parietal lobes often result in cognitive and emotional changes; in the spinal cord, problems arise more easily in the lower limbs. Changes in the optic nerve and occipital lobe can cause visual problems. This is the neurological desease that causes most limitations in the young adult active population. Given the reasonably young age at which symptoms begin, there will be a decrease in quality of life, more significant than in other chronic diseases. Discussion and Conclusions Although the bibliography is not scarce, the emphasis in the vast majority of articles is not on Occupational Health or Safety. It would be relevant for some teams working in large companies with some prevalence, to evaluate the cases in detail, describing the main problems detected, proposed measures and their subsequent evaluation, in order to publish not only the path, but also the conclusions obtained, for greater dissemination of the subject.

Resumen: Este artículo tiene como objetivo analizar los cambios en la dinámica residencial y comercial de un barrio del sur de Belo Horizonte. Utilizando el registro del Impuesto sobre Bienes Urbanos y Territoriales y el registro del Impuesto sobre Transmisiones Inmobiliarias, fue posible, no sólo identificar y mapear las nuevas propiedades residenciales y comerciales construidas en el barrio en la última década, sino delinear el perfil de sus nuevas residentes y consumidores. Se tiene en cuenta el concepto de gentrificación como un proceso de sustitución de una clase social de menor estatus por otra de mayor estatus, para examinar los resultados encontrados. Los datos apuntan a un proceso de cambio físico, marcado por la mayor oferta de edificios con alto nivel de acabado y alto valor, dirigidos a un grupo social de mayor estatus que los residentes anteriores. El principal actor detrás de estos cambios es el mercado inmobiliario. Resumen Horizonte Inmobiliarias posible década consumidores encontrados físico valor anteriores inmobiliario

Abstract: This article aims to analyze changes in the residential and commercial dynamics of a neighborhood in the south of Belo Horizonte. Using the Urban Property and Territorial Property Tax register and the Real Estate Transfer Tax register, it was possible, not only to identify and map the new residential and commercial properties built in the neighborhood in the last decade, but to outline the profile of its new residents and consumers. The concept of gentrification is taken into account as a process of replacing a social class with a lower status by another with a higher status, to examine the results found. The data point to a process of physical change, marked by the greater supply of buildings with a high standard of finishing and high value, aimed at a social group with a higher status than the previous residents. The main actor behind these changes is the real estate market. Abstract Horizonte possible decade consumers found change value market

Resumo: Este artigo tem como objetivo analisar as mudanças nas dinâmicas residenciais e comerciais de um bairro da Zona Sul de Belo Horizonte. Utilizando o cadastro do Imposto sobre a Propriedade Predial e Territorial Urbana e o cadastro do Imposto sobre a Transmissão de Bens Imóveis, foi possível, não apenas identificar e mapear os novos imóveis residenciais e comerciais construídos no bairro na última década, mas esboçar o perfil de seus novos moradores e consumidores. Leva-se em conta o conceito de gentrificação enquanto um processo de substituição de uma classe social com status inferior por outra com status superior, para examinar os resultados encontrados. Os dados apontam para um processo de mudança física, marcada pela maior oferta de edifícios com alto padrão de acabamento e alto valor, voltados para um grupo social com status superior ao dos antigos moradores. Tais mudanças têm como principal ator o mercado imobiliário. Resumo Horizonte Imóveis possível década consumidores Levase Leva se encontrados física valor imobiliário

Abstract This study focuses on analyzing deontic modal verbs present in two recipe books written by women in 19th-century England: "A Lady" (1818) and Beeton (1875). A contrastive analysis is conducted to examine how these authors use these verbs, common in instructional texts like recipes due to their prescriptive nature. Objectives include identifying deontic modal verbs, detecting similarities or differences in their usage, and observing potential variations between the two texts. Despite significant changes in the era, traditional roles of women as caregivers and healers persist. The presentation contextualizes the 19th century and women's roles, introducing key concepts such as gender, text type, and register. Likewise, the nature of modal verbs is explored, defining the term modality, as well as its main types. Subsequently, the study employs corpus linguistics methodology using the Corpus of Women’s Instructive Texts in English(COWITE). In this analysis, quantitative and qualitative approaches are combined to examine ocurrences. The results reveal both similarities and differences in the use of these modal verbs, which seem to be attributed to distinct linguistic styles between the authors.

Resumen Este estudio se enfoca en analizar los verbos modales deónticos presentes en dos libros de recetas escritos por mujeres en la Inglaterra del siglo XIX: “A Lady” (1818) y Beeton (1875). Se realiza un análisis contrastivo de cómo las autoras emplean estos verbos, comunes en textos instructivos como las recetas debido a su naturaleza prescriptiva. Los objetivos incluyen identificar los verbos modales deónticos, detectar similitudes o diferencias en su uso y observar posibles variaciones entre ambos textos. A pesar de los cambios significativos en la época, el papel tradicional de las mujeres como cuidadoras y curanderas persiste. La presentación contextualiza el siglo XIX y el papel de la mujer, introduciendo conceptos clave como género, tipo de texto y registro. Asimismo, se explora la naturaleza de los verbos modales y se define el término de modalidad, así como sus principales tipos. Posteriormente, se utiliza la metodología de lingüística de corpus con el Corpus of Women’s Instructive Texts in English (COWITE). En este análisis, se combina enfoques cuantitativos y cualitativos para examinar ocurrencias. Los resultados arrojan tanto similitudes como diferencias en el empleo de estos verbos modales, que parecen deberse a estilos lingüísticos diferentes entre las autoras.

Abstract: One of the most recent and important changes in power distribution systems is self-consumption, activity in which one or several users install equipment (typically solar panels) to generate their own electricity and, in some cases, inject surplus energy into the grid. These users require a bidirectional meter, which does not register the active energy of all the load, making difficult the assessment of its power factor. This paper presents a methodology to assess the power factor in users with power generation equipment for self-consumption. The methodology details the measurement equipment needed, the steps to calculate the load’s average power factor, and, for some cases, the penalization method. The results indicate that the proposed methodology isolates correctly the power generation effect from the power factor calculation, and this, in turn, avoids incorrect penalties.

Resumen: Uno de los cambios más recientes e importantes en las redes de distribución de energía eléctrica es el autoabastecimiento, actividad en la que uno o varios usuarios instalan equipos (usualmente panales fotovoltaicos e inversores) para generar su propia energía eléctrica, autoabastecerse y, en algunos casos, inyectar excedentes de energía a la red. Estos usuarios requieren de un medidor bidireccional, el cual no registra la energía activa de toda la carga, haciendo difícil la evaluación de su factor de potencia. Este artículo presenta una metodología para la evaluación del factor de potencia en un usuarios con autoabastecimiento. La metodología detalla los equipos de medición necesarios, los pasos para calcular el factor de potencia medio mensual de la carga, y, para los casos necesarios, el método de penalización por bajo factor de potencia. Los resultados muestran que, la metodología propuesta aísla correctamente el efecto de la generación del cálculo del factor de potencia, y esto, a su vez, evita penalizaciones incorrectas.

SUMMARY: Simple hepatic cysts of the liver (SHCL) are incidentally detected in the liver, and may be solitary or multiple. There is sufficient evidence supporting the role of laparoscopic surgery in the treatment of these lesions. The aim of this study was to report the outcomes of laparoscopic treatment in patients with BSHCs in terms of postoperative complications (POC). Case series.All patients who underwent laparoscopic surgery for BSLC at RedSalud Mayor Clinic between January 2013 and December 2023 were included. Preoperative assessment consisted of general examinations, determination of ELISA-IgE and IgG for hydatidosis, abdominal ultrasound or computed tomography. The outcome variable was the development of postoperative complications (POCs). Descriptive statistics were used. During the study period, 22 patients with BSLC were operated, resecting them a total of 34 cysts. The median age of the series was 59 years, and 81.8 % of patients were female. The median sonographic diameter of the lesions was 9 cm. Subtotal pericystectomy was performed in all of them, without using drainage. In 45.4 % of cases simultaneously cholecystectomy for coexistent cholelithiasis was performed. The median operative time was 52 minutes. No patients needed to be converted. The series does not register POC or mortality. The median hospital stay was 1 day. The histopathological study confirmed "biliary type cyst" in all cases. With a minimum follow-up of 6 months, no late postoperative complications or recurrence of the resected lesions have been observed. The treatment applied to this series of cases was associated with a short hospital stay and good short- and medium-term outcomes.

RESUMEN: Los quistes hepáticos benignos simples del hígado (QHBSH) se detectan de forma incidental, pudiendo ser únicos o múltiples. Existe suficiente evidencia que avala el rol de la cirugía laparoscópica en el tratamiento de estas lesiones. El objetivo de este estudio fue informar los resultados del tratamiento laparoscópico en pacientes con QHBSH en términos de complicaciones postoperatorias (CPO). Serie de casos. Se incluyeron todos los pacientes intervenidos quirúrgicamente vía laparoscópica por QHBSH en la Clínica RedSalud Mayor entre enero de 2013 y diciembre de 2023. El estudio preoperatorio consistió en exámenes generales, determinación de ELISA-IgE e IgG para hidatidosis, ecotomografía abdominal o tomografía computarizada. La variable resultado fue desarrollo de CPO. Se utilizó estadística descriptiva. En el período estudiado, se intervinieron 22 pacientes con QHBSH, resecándose en ellos, un total de 34 quistes. El 81,8 % de los casos eran de sexo femenino; y la mediana de edad de la serie fue de 59 años. La mediana del diámetro ecográfico de las lesiones fue de 9 cm. Se realizó periquistectomía subtotal en todos ellos, sin utilización de drenaje. En el 45,4 % de los casos se ejecutó de forma simultánea una colecistectomía por colelitiasis coexistente. La mediana del tiempo quirúrgico fue de 52 minutos. No fue necesario convertir a ningún paciente. La serie no registra CPO ni mortalidad. La mediana de estancia hospitalaria fue de 1 día. El estudio histopatológico confirmó “quiste de tipo biliar” en la totalidad de los casos. Con un seguimiento mínimo de 6 meses, no se ha evidenciado CPO tardía ni reaparición de las lesiones resecadas. El tratamiento aplicado a esta serie de casos se asoció a escasa estancia hospitalaria y buena evolución a corto y mediano plazo.

SUMMARY BACKGROUND: Cancer-related fatigue is a pervasive symptom, affecting up to 90% of cancer patients throughout their illness, and can persist well after treatment has ended. Despite its prevalence, no definitive evidence-based treatment exists, leading to an abundance of proposed alternatives, including natural supplements. To further explore the potential effects of guaraná on cancer-related fatigue, a systematic review with meta-analysis was conducted and registered on the International Prospective Register of Systematic Reviews (CRD42023484144). METHODS: A thorough search of PubMed/MEDLINE and Cochrane Library was conducted using MeSH terms and related keywords for cancer-related fatigue and guaraná. Eligible studies were selected according to predetermined criteria and assessed for quality in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Data extraction was independently performed by two reviewers, with any discrepancies resolved by a third researcher. RESULTS: In total, 4 full articles and 1 abstract, encompassing a total of 229 patients from 2009 to 2023, were included in the meta-analysis. Despite high heterogeneity between studies (I2=78%, ꭓ2=18.51, df=4, p=0.0010), the analysis revealed a significant benefit of using guaraná to alleviate cancer-related fatigue, with a standard mean difference of −0.77 (95%CI −1.34, −0.21) and a test for the overall effect of Z=2.68 (p=0.007). CONCLUSION: This meta-analysis provides support for the use of guaraná in the treatment of cancer-related fatigue. However, further investigation through larger prospective randomized controlled trials is necessary to validate these findings. BACKGROUND Cancerrelated Cancer symptom 90 illness ended prevalence evidencebased evidence based exists alternatives supplements cancerrelated metaanalysis meta CRD42023484144. CRD42023484144 CRD . (CRD42023484144) METHODS PubMedMEDLINE PubMed MEDLINE Interventions reviewers researcher RESULTS abstract 22 200 2023 metaanalysis. analysis. I2=78%, I278 I I2 78 (I2=78% ꭓ21851 ꭓ ꭓ2 18 51 ꭓ2=18.51 df4 df df=4 p=0.0010, p00010 p p=0.0010 , 0 0010 p=0.0010) 077 77 −0.7 95%CI 95CI CI 95 134 34 −1.34 −0.21 021 21 Z268 Z 2 68 Z=2.6 p=0.007. p0007 p=0.007 007 (p=0.007) CONCLUSION However findings 9 CRD4202348414 (CRD42023484144 20 202 I2=78% I27 7 (I2=78 ꭓ2185 5 ꭓ2=18.5 df= p0001 p=0.001 001 07 −0. 13 3 −1.3 −0.2 02 Z26 6 Z=2. p000 p=0.00 00 (p=0.007 CRD420234841 (CRD4202348414 I2=78 (I2=7 ꭓ218 ꭓ2=18. −0 −1. Z2 Z=2 p00 p=0.0 (p=0.00 CRD42023484 (CRD420234841 I2=7 (I2= ꭓ21 ꭓ2=18 − −1 Z= p0 p=0. (p=0.0 CRD4202348 (CRD42023484 I2= (I2 ꭓ2=1 p=0 (p=0. CRD420234 (CRD4202348 (I ꭓ2= p= (p=0 CRD42023 (CRD420234 (p= CRD4202 (CRD42023 (p CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

Abstract Introduction CyberKnife (CK) radiosurgery is a treatment strategy for vestibular schwannoma (VS). Objectives To evaluate hearing preservation (HP) after CK for VS. Data Synthesis The study was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, and it was registered at the International Prospective Register of Systematic Reviews (PROSPERO, under number CRD42021250300). The inclusion criteria were based on the population, intervention, comparison, outcome, timing and study design (PICOTS) strategy: population – patients with VS; intervention – CK; Comparison – none; Outcome – serviceable HP defined by Gardner and Robertson as grades I or II, or by the American Academy of Otolaryngology and Head and Neck Surgery as classes A or B; timing – mean follow-up longer than 1 year; and study design – retrospective or prospective studies. The exclusion criteria were: studies not published in English; studies published before January 2000 and after October 2021; and studies only including patients with neurofibromatosis type 2 or submitted to a previous treatment. The PubMed/MEDLINE, EMBASE, Web of Science, Cochrane Library, LILACS, and IBECS databases were used and last searched on October 27th, 2021. Statistical heterogeneity was assessed using I2 statistics. The appraisal checklist was used to assess the risk of bias in the included studies. A total of 222 studies were analyzed, and 13 were included in the synthesis, which represents 493 participants with serviceable hearing before intervention. The mean HP rate after CK using a random effects model was of 68% (95% confidence interval [95%CI]: 59–76%) at a mean follow-up of 42.96 months. Conclusion The longer follow-up period was associated with a lower HP rate after CK radiosurgery for VS in the qualitative synthesis. (CK . (VS) (HP MetaAnalyses Meta Analyses PRISMA (PRISMA statement PROSPERO, PROSPERO (PROSPERO CRD42021250300. CRD42021250300 CRD CRD42021250300) comparison outcome PICOTS (PICOTS none II B followup follow up year English 200 2021 PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE EMBASE Science Library LILACS 27th th statistics 22 analyzed synthesis 49 68 95% 95 (95 95%CI 95CI CI [95%CI] 59–76% 5976 59 76 4296 42 96 42.9 months (VS CRD4202125030 20 202 4 6 9 (9 [95%CI 59–76 597 5 7 429 42. CRD420212503 ( 59–7 CRD42021250 59– CRD4202125 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

Resumen En este texto se reporta la validación de una versión de la escala de teorías implícitas de comprensión lectora (ETICOLEC), modificada para futuros docentes de español de una universidad pública de la Península de Yucatán y describimos las teorías implícitas encontradas en la muestra. Seguimos el procedimiento de Prat y Doval (2005) para incorporar nuevos ítems a la escala y poner a prueba sus propiedades psicométricas mediante análisis de componentes principales y de consistencia interna con alfa de Cronbach, utilizando el programa Statistical Package for the Social Sciences (SPSS, v. 26). Además de registrarse propiedades psicométricas, el estudio identificó tres subescalas con buena consistencia interna, cada una de las cuales mide una teoría implícita o conjunto de creencias sobre la comprensión lectora. Algunos participantes sostienen más de una teoría implícita, en tanto que un grupo más grande no sustentan ninguna. Ello puede tener implicaciones para sus procesos de alfabetización académico disciplinar y su futura práctica docente.

Abstract In this text it is reported the validation of a new version of the scale of implicit theories of reading comprehension (ETICOLEC as per its Spanish acronym) modified for future Spanish teachers at a public university in the Yucatán Peninsula. We also describe their implicit theories. A standard procedure (Prat y Doval 2005) was used to add new items to the scale and test its psychometric properties using principal component analysis and internal consistency analysis with Cronbach’s alpha. Calculations were performed with the use the Statistical Package for the Social Sciences (SPSS v. 26). Besides to register psychometric properties, the study identified three subscales with good internal consistency, each of which measures an implicit theory or set of beliefs about reading comprehension. A few participants hold more than one implicit theory, while a larger group does not sustain any of them. This may have implications for their disciplinary literacy processes and their future teaching practices.

Cognitive behavioural therapy (CBT) is a well-researched and evidence-based psychotherapy that is underutilised in Africa. CBT presents opportunities for occupational therapists to expand their practice, for example by promoting engagement in meaningful and purposeful activity (behavioural activation), engaging with a mental health care user's thoughts during and after participation in activity (cognitive restructuring), and grading exposure to traumatic activities (exposure therapy). However, it is also critical that occupational therapists using CBT techniques culturally adapt these for their practice context and engage in professional development activities to develop their competencies as CBT practitioners. This commentary highlights recent advances in CBT practice and calls for CBT and associated techniques to be made more accessible to mental health care users in Africa. IMPLICATIONS FOR PRACTICE • The relationship between participation and mental health is gaining prominence within the field of CBT. Occupational therapists should position themselves as experts in the therapeutic use of activity. • Occupational therapists using CBT techniques should culturally adapt their practice to meet the mental health needs of people living in Africa. • Occupational therapists using CBT techniques should follow internationally recognised pathways to CBT professional development, and register as Affiliated Members of the Cognitive Behavioural Therapy Association of South Africa

ABSTRACT Introduction/framework/objectives: The use of this equipment is increasingly common in various professional sectors and for longer periods, whether within a work shift or throughout life. Thus, their interaction with workers' health becomes increasingly relevant, resulting in the need to research what has been described on this topic. This review aims to summarize the most relevant information published, so that professionals in the Health and Safety teams have more tools to guide the matter and so that the workers themselves better understand what could be at stake and are more receptive to protective measures that may be proposed. Methodology: This is a Bibliographic Review, initiated through research carried out in april of 2023, in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content: Acoustic shock can be secondary to an intense and unexpected noise and its prevalence can vary between 13 and 22%; however, it is a complex and controversial concept. It is eventually characterized by otalgia, tinnitus, vertigo, a burning sensation near the ear and anxiety. Acoustic shocks can cause cochlear trauma. The use of Headsets does not seem to cause more fatigue than noise from other sources, as long as it is of the same intensity. Most Call Centers operators work in an open space, with colleagues, which increases exposure to noise. The higher this is, the higher the eqquipment is placed. Susceptibility to hearing loss presents individual variability and interaction with some comorbidities (such as smoking, high blood pressure, diabetes and dyslipidemia); as well as gender and age. Most of these operators listen well; even if they report difficulty in perceiving words with ambient noise and tinnitus. Discussion and Conclusions: Although it is quite common for Call Centers workers to mention, during Occupational Medicine consultations, complaints that they associate with overall noise (especially that produced by Headsets); in reality, the bibliography on the topic is scarce and not very robust. Even so, it describes some very brief instructions to try to minimize the damage and enhance the well-being, satisfaction and productivity of professionals who use this type of equipment. It would be interesting to investigate the subject a little better, better understand the national panorama and publicize this in scientific publications.

RESUMO Introdução/enquadramento/objetivos: O uso deste equipamento é cada vez mais frequente em diversos setores profissionais e por períodos mais prolongados, quer dentro de um turno de trabalho, quer ao longo da vida. Assim, a interação destes com a saúde dos trabalhadores fica cada vez mais relevante, surgindo a necessidade de pesquisar o que se tem descrito sobre este tema. Esta revisão pretende resumir o que de mais pertinente se publicou, de forma que os profissionais das equipas de Saúde e Segurança tenham mais ferramentas para orientar o assunto e para que os próprios trabalhadores percebam melhor o que poderá estar em causa e estejam mais recetivos a medidas de proteção eventualmente propostas. Metodologia: Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023 nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo: O choque acústico pode ser secundário a um ruido intenso e inesperado e a sua prevalência pode variar entre 13 a 22%; contudo, trata-se de um conceito complexo e controverso. Carateriza-se eventualmente por otalgia, zumbido, vertigem, sensação de queimadura próxima ao ouvido e ansiedade. Os choques acústicos podem causar trauma coclear. O uso de Headsets não parece causar mais fadiga que ruido com outras origens, desde que com a mesma intensidade. A maioria dos operadores de Call Center trabalha em espaço aberto, com colegas, o que potencia a exposição ao ruído. Quanto mais elevado este for, mais alto é colocado o som do equipamento, para conseguir ouvir a chamada. A suscetibilidade à perda de audição apresenta variabilidade individual e interação com algumas comorbidades (como tabagismo, hipertensão arterial, diabetes e dislipidemia); bem como sexo e idade. A maioria dos operadores de Call Center ouve bem; apesar de mencionarem dificuldade em perceber as palavras com o ruído ambiente e zumbido. Discussão e Conclusões: Ainda que seja bastante frequente estes trabalhadores referirem, durante as consultas de Medicina do Trabalho, queixas que associam ao ruido global (com destaque pelo produzido pelos Headsets); na realidade, a bibliografia sobre o tema é escassa e pouco robusta. Ainda assim, nela estão descritas algumas indicações muito sumárias para tentar minorar os danos e potenciar o bem-estar, satisfação e produtividade dos profissionais que usam este tipo de equipamento. Seria interessante investigar um pouco melhor o assunto, perceber melhor o panorama nacional e divulgar tal em publicações científicas.