Parthenolide (PTN) is a secondary metabolite of the plant Tanacetum parthenium (L.) Schulz Bip. and is considered the chemical marker of this species. This sesquiterpene lactone (germacrene skeleton) has been described as responsible for the biological activity of the leaf extract. In addition, several studies in the literature have demonstrated its antiparasitic and antineoplastic activity. However, there is a need for knowledge of other safety parameters, such as pharmacokinetic, pharmacodynamic and toxicity evaluations. Therefore, in this investigation, the in vitro metabolism of parthenolide was performed with rat liver microsomes and biomimetic metabolism (such as cytochrome P-450 system) using organometallic catalysts. The biomimetic procedure was validated since the major compound of biomimetic oxidative reaction with meta-chloroperbenzoic acid catalyzed by metalloporphyrin 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin iron(III) chloride was also observed with rat liver microsomes. Previous chemoenzymatic synthesis studies of PTN afforded the same epoxide formation, this major oxidative compound was isolated and fully characterized as (1 R,10R)-epoxyparthenolide based on experimental and theoretical calculations of infrared (IR) and vibrational circular dichroism (VCD) data at the B3PW91/6-311G. Furthermore, for the first time, this metabolite was evaluated for trypanocidal and leishmanicidal activity. The mean inhibitory concentration (IC50) values were lower for PTN than its metabolite and showed significant cytotoxic effects for both parasites. This finding holds promise for addressing neglected diseases.

RESUMO: Visando a qualidade nutricional e funcional dos resíduos agroindustriais, o estudo teve como objetivo estabelecer a mistura ternária de farinhas elaboradas com resíduos de abacaxi, acerola e maracujá utilizando o delineamento simplex-centroide, assim como avaliar seus efeitos nas características físico-químicas e sensoriais em gelados comestíveis. Com o planejamento de misturas, nove componentes ternários das farinhas foram aplicados em formulações de gelados comestíveis para avaliação dos escores de aceitação para os atributos sabor, textura e impressão global, bem como os parâmetros físico-químicos (pH, acidez, sólidos solúveis e parâmetros de cor) e microbiológicos (coliformes termotolerantes a 45 ºC, Enterobacteriaceae e Salmonella). O delineamento simplex-centroide demonstrou que o modelo cúbico melhor prediz os resultados para os atributos sensoriais analisados. Os gráficos de superfície de resposta indicaram a área de maior aceitação nas formulações com o máximo percentual estabelecido para a farinha com os resíduos de acerola. O maior índice de aceitabilidade foi atribuído a mistura ternária constituída com 60%, 30% e 10% para as farinhas de abacaxi, maracujá e acerola, respectivamente. Os resultados indicaram que o sorbet enriquecido com a farinha composta pela mistura ternária é um produto com potencial para exploração, além de contribuir para a redução dos impactos ambientais gerados pelo grande e inadequado descarte de resíduos do processamento agroindustrial de frutas no ecossistema. RESUMO agroindustriais abacaxi simplexcentroide, simplexcentroide simplex centroide, centroide físicoquímicas físico químicas misturas sabor global físicoquímicos químicos pH, pH (pH acidez cor coliformes 4 ºC Salmonella. Salmonella . Salmonella) analisados 60 60% 30 10 respectivamente exploração ecossistema 6 3 1

ABSTRACT: To improve the nutritional and functional quality of agro-industrial waste, his study established a ternary mixture of flours made from pineapple, acerola, and passion fruit waste using the simplex-centroid design, as well as to evaluate their effects on the physicochemical and sensory characteristics of edible ice cream. Using mixture planning, nine ternary flour components were applied to edible ice cream formulations to evaluate acceptance scores for taste, texture, and overall impression attributes, as well as physicochemical parameters (pH, acidity, soluble solids, and color parameters) and microbiological parameters (thermotolerant coliforms at 45 ºC, Enterobacteriaceae and Salmonella). The simplex-centroid design demonstrated that the cubic model best predicts the results for the analyzed sensory attributes. The response surface graphs indicated the area of greatest acceptance in the formulations with the maximum percentage established for the flour with acerola waste. The highest level of acceptability was given to the ternary mixture of 60%, 30%, and 10% pineapple, passion fruit, and acerola flours, respectively. The results indicated that sorbet enriched with flour composed of the ternary mixture is a product with the potential for exploitation, as well as contributing to the reduction of environmental impacts generated by the large and improper disposal of agro-industrial fruit processing residues in the ecosystem. ABSTRACT agroindustrial agro industrial pineapple simplexcentroid simplex centroid planning taste texture attributes pH, pH (pH acidity solids thermotolerant 4 ºC Salmonella. Salmonella . Salmonella) 60 60% 30 30% 10 respectively exploitation ecosystem 6 3 1

RESUMO: Este estudo explorou o uso exclusivo do ultrassom (US) para extrair proteínas das espinhas dorsais da carpa-capim (Ctenopharyngodon idella) em baixas temperaturas e examinou seu impacto na hidrofobicidade, solubilidade, perfil eletroforético e níveis de sulfidrilas. As espinhas dorsais foram tratadas com 35 e 130 kHz por 20, 30 e 40 minutos a 14 ºC, resultando em duas frações de proteínas: sólida (TPS) e líquida (TPL). O US aumentou o rendimento em comparação com a fração não sonificada. TPL (35 kHz) apresentou uma redução de 16% nos níveis totais e livres de sulfidrila e um aumento de 25% na hidrofobicidade. O US induziu alterações na conformação proteica e na intensidade das bandas, especialmente entre 25 e 100 kDa para TPL a 130 kHz e abaixo de 30 kDa para TPS a 35 kHz. Este estudo demonstrou a eficácia do US na extração e na modificação de algumas propriedades das proteínas de subprodutos de peixe, facilitando assim seu emprego no desenvolvimento de produtos alimentícios inovadores. RESUMO (US carpacapim carpa capim Ctenopharyngodon idella hidrofobicidade solubilidade sulfidrilas 3 13 20 4 1 ºC (TPS TPL. . (TPL) sonificada (3 16 bandas 2 10 peixe inovadores (TPL (

ABSTRACT: This study explored the use only of ultrasound (US) for extracting proteins from grass carp (Ctenopharyngodon idella) backbones at low temperature and examined its impact on hydrophobicity, solubility, electrophoretic profile, and sulfhydryl levels. Backbones were treated with 35 and 130 kHz for 20, 30, and 40 minutes at 14 ºC, resulting in two protein fractions: solid (TPS) and liquid (TPL). US increased yield compared to the non-sonicated fraction. TPL (35 kHz) exhibited a 16% reduction in total and free sulfhydryl levels and a 25% increase in hydrophobicity. US induced protein conformation and band intensity alterations, particularly between 25 to 100 kDa for TPL at 130 kHz and below 30 kDa for TPS at 35 kHz. This study demonstrated the efficacy of US for protein extraction from fish by-products and its capacity to modify protein characteristics, facilitating the development of innovative food products. ABSTRACT (US Ctenopharyngodon idella hydrophobicity solubility profile 3 13 20 4 1 ºC fractions (TPS TPL. . (TPL) nonsonicated non sonicated fraction (3 16 alterations 2 10 byproducts by products characteristics (TPL (

Citronellyl esters present broad applications in the cosmetic, pharmaceutical, and food industries due to their organoleptic and biological properties. Lipase-catalyzed acylation of citronellol has been a suitable way to obtain these natural esters on a high scale. This work describes the lipase-catalyzed acylation of citronellol through esterification and transesterification with linear acylating agents (C3-C18) using Novozym®435 as a biocatalyst. The results show that all esters achieved not less than 91% conversion from an esterification model, showing a good reaction profile. Citronellyl propionate and laurate were selected for study in a transesterification reaction model, and it resulted in a lower reaction time for ester conversions. As an example, we highlight citronellyl propionate production, which approximately 10 g L-1 of the product was obtained after 1.5 h of esterification compared to 2 min by transesterification. The final esters were purified with high purity (≥ 90%) and identified by gas chromatography-mass spectrometry (GC-MS), and their structures were elucidated by 1H and 13C nuclear magnetic resonance (NMR). Enzyme recycling was evaluated and Novozym®435 was able to be applied for at least 20 cycles. Results demonstrated the efficiency of acylation reactions catalyzed by this enzyme and showed the potential of the methodology for the production and purification of flavor esters. cosmetic pharmaceutical properties Lipasecatalyzed Lipase scale lipasecatalyzed lipase C3C18 CC C3 C18 C (C3-C18 Novozym435 Novozym 435 Novozym®43 biocatalyst 91 model profile conversions example 1 L1 L L- 15 5 1. ≥ ( 90% 90 chromatographymass chromatography mass GCMS, GCMS GC MS , (GC-MS) H NMR. NMR . (NMR) cycles C3C1 C1 (C3-C1 Novozym43 43 Novozym®4 9 (GC-MS (NMR C3C (C3-C Novozym4 4 Novozym®

ABSTRACT Introduction/framework/objectives Salt production, especially using artisanal methods, does not exist in all countries, given the climatic and logistical requirements. Portugal has some tradition in this sector, but even so, most professionals working in Occupational Health and Safety have no experience in the area. The aim of this review was to summarize the most relevant and recent publications, to improve their performance capacity and enhance the productivity, satisfaction and well-being of the workers involved. Methodology This is a Bibliographic Review, initiated through a search carried out in April 2023 in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content Salt pans can be inland (far from the sea, using groundwater with a high salt content) or coastal. The former are scarcer in Portugal and only exist between Lisbon and Coimbra. Over time, in our country, evaporation was carried out by fire and sun. The latter is believed to have been developed by the Romans who created the first version of salt flats. At national level there is evidence of salt production since the end of the Neolithic, but here more frequently with the use of fire. Throughout Europe there has been a decline in artisanal versus industrial salt production, even in sea salt pans (especially on the northwest coast of France and, in Portugal, on the western coasts). Artisanal production in our country is more prevalent in the Figueira da Foz area. The product obtained via artisanal production has better quality, particularly in terms of flavor and nutritionally (via industrial production the taste is more metallic). Portugal is a large producer and consumer of traditional salt. The climatic characteristics suit production, due to summers with frequent high temperatures and strong, hot winds. National salt was and is consumed in other European countries; for presenting superior quality, even though it is more expensive. Production depends on the climate, namely insolation (number of hours in the sun), precipitation, temperature, cloudiness and winds (which affect evaporation). In other words, this is more intense and faster if the air temperature is higher, such as with more dry winds (which are generally more frequent in summer); low precipitation is also favorable. Salt production has been increasing, due to growing industrial needs. To be used in this last situation, it must be at 100% purity. Discussion and Conclusions No bibliography was found that referred the dimension of occupational health and safety in this professional sector. Based on the authors' theoretical and practical experience, the most relevant risk factors and risks in the sector are described: ultraviolet radiation and possible skin cancer, cataracts and other associated injuries; thermal discomfort and eventual higher accident rates associated with motor incoordination, worse cardiovascular adjustment, as well as disorientation and ability to make decisions; forced/maintained loads and/or postures and possible musculoskeletal injuries, emergence/worsening of hernia pathology and falling objects at the same level and possible bruises, skin lacerations and/or fractures. It would be interesting to learn more about the national panorama of this sector, through studies that hierarchically stratify the risk, also accurately describing occupational illnesses and associated accidents, as well as more effective measures to mitigate these issues.

RESUMO Introdução/enquadramento/objetivos A produção de sal, sobretudo com métodos artesanais, não existe em todos os países, dadas as exigências climáticas e logísticas. Portugal apresenta alguma tradição nesse setor mas, ainda assim, a maioria dos profissionais a exercer na Saúde e Segurança Ocupacionais não tem experiência na área. Pretendeu-se com esta revisão resumir o que mais relevante e recente se publicou, de forma a melhorar a capacidade de atuação destes e a potenciar a produtividade, satisfação e bem-estar dos trabalhadores afetos. Metodologia Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023 nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo As salinas podem ser interiores (afastadas do mar, usando água subterrânea com elevado conteúdo em sal) ou litorais. As primeiras são mais escassas em Portugal e apenas existem entre Lisboa e Coimbra. Ao longo do tempo, no nosso país, a evaporação era realizada pelo fogo e sol. Esta última acredita-se que foi desenvolvida pelos romanos que, de certa forma, criaram a primeira versão das salinas. A nível nacional há evidência de produção de sal desde o final do Neolítico, mas aqui mais frequente com a utilização do fogo. Por toda a Europa tem existido um declínio da produção artesanal de sal, versus industrial, mesmo em salinas marítimas (sobretudo na costa noroeste de França e, em Portugal, na costa ocidental). A produção artesanal no nosso país é mais prevalente na zona da Figueira da Foz. O produto obtido via artesanal tem mais qualidade, nomeadamente a nível de sabor e nutricionalmente (via industrial o paladar é um pouco mais metálico). Portugal é um grande produtor e consumidor de sal tradicional. As caraterísticas climáticas adequam-se à produção, devido aos verões com temperaturas elevadas frequentes e ventos fortes e quentes. O sal nacional era e é consumido noutros países europeus, por apresentar qualidade superior, mesmo tendo um preço mais elevado. A produção depende do clima, nomeadamente a insolação (número de horas ao sol), precipitação, temperatura, nebulosidade e ventos (que condicionam a evaporação). Ou seja, esta é mais intensa e rápida se a temperatura do ar for mais elevada, tal como com mais ventos secos (que geralmente são mais frequentes no Verão); a baixa precipitação também é favorável. A produção de sal tem vindo a aumentar, até pelas crescentes necessidades industriais. Para ser usado nesta última situação, deverá estar no patamar de 100% de pureza. Discussão e Conclusões Não se encontrou bibliografia que fizesse referência à dimensão da saúde e segurança ocupacionais neste setor profissional. Em função de experiência teórica e prática dos autores, descrevem-se os fatores de riscos e riscos mais relevantes do setor: radiação ultravioleta e eventual cancro de pele, cataratas e outras lesões associadas; desconforto térmico e eventual maior sinistralidade associada a descoordenação motora, pior ajuste cardiovascular, bem como desorientação e capacidade de tomar decisões; cargas e/ou posturas forçadas/mantidas e eventuais lesões músculo-esqueléticas, surgimento/agravamento de patologia herniária e queda de objetos e ao mesmo nível e eventuais equimoses, lacerações cutâneas e/ou fraturas. Seria interessante conhecer melhor o panorama nacional deste setor, através de estudos que estratificassem hierarquicamente o risco, descrevendo ainda com rigor as doenças profissionais e acidentes associados, bem como medidas mais eficazes para atenuar essas questões.

RESUMEN El artículo aborda una problemática relacionada con la formación del Técnico Medio en los Institutos Politécnicos Agropecuarios en la especialidad Agronomía de Montaña, las actividades manuales agropecuarias. Su objetivo, ofrecer algunas consideraciones sobre la realización de estas actividades en este contexto, ello contribuirá a elevar la calidad del proceso de enseñanza aprendizaje, a tenor con el Tercer Perfeccionamiento Educacional. De ahí la necesidad de su integración con las asignaturas de formación profesional básica específica. Entre los métodos aplicados: análisis-síntesis, inducción-deducción, observación, análisis del producto de la actividad y entrevista. La propuesta mejora la labor de orientación a los profesores.

ABSTRACT The article approaches a related problem with the formation of the half technician in the polytechnic agricultural institutes in the agronomy speciality of mountain, the manual agricultural activities. Your objective, offer some considerations on the realization of these activities in this context, it will contribute to raise the quality of the process of apprenticeship teaching, on the base of the exigencies of the third educational perfecting. In this way the need of your integration with the basic specific courses. Between the applied methods were: analysis, synthesis, induction, deduction, observation, analysis of the product of the activity and interviews. The better proposal the labor of orientation to the teachers.

RESUMEN Paraguay ha aumentado la inversión en educación en la última década por medio del Fondo Nacional de Inversión Pública y Desarrollo (FONACIDE) cuya finalidad consiste en abordar las carencias que afectan a la educación paraguaya. Entonces, considerando la creciente preocupación por la gestión de los recursos públicos dada la escasa infraestructura y el deficiente servicio del almuerzo escolar, en este trabajo se pretende analizar la eficiencia de la gestión de los gastos públicos en educación del FONACIDE de los departamentos de Paraguay durante el período 2015 a 2017, a través de la aplicación de la técnica Data Envelopment Analysis (DEA) con análisis de ventana y retornos variables de escala con orientación producto. La técnica DEA con análisis de ventana consiste en medir el nivel de eficiencia de varias Decision Making Units (DMUs) en diferentes períodos de tiempo basado en el principio de promedios móviles. Los resultados muestran que la ineficiencia técnica pura media nacional es del 11,04%, por tanto, los departamentos en general podrían mejorar sus indicadores educativos utilizando los mismos niveles de financiamiento. Además, el mayor acceso a recursos no está vinculado a mejores rendimientos educativos. Por tanto, para potenciar el rendimiento educativo es necesario establecer otros criterios de redistribución presupuestaria del FONACIDE, considerando la necesidad de infraestructura y número de alumnos matriculados por departamento.

ABSTRACT Paraguay has increased investment in education over the past decade through the National Fund for Public Investment and Development (FONACIDE), whose goal is to address the deficiencies affecting Paraguayan education. Considering the growing concern over the management of public resources given the inadequate infrastructure and poor school lunch service, this paper aims to analyze the efficiency of public spending management in education by FONACIDE in the departments of Paraguay during the period 2015 to 2017. This is achieved through the application of the Data Envelopment Analysis (DEA) technique with window analysis and variable returns to scale with product orientation. The DEA technique with window analysis measures the efficiency level of several Decision-Making Units (DMUs) over different periods based on the moving averages principle. The results show that the average national pure technical inefficiency is 11.04%, meaning that the departments, in general, could improve their educational indicators using the same funding levels. Additionally, greater access to resources is not linked to better educational outcomes. Therefore, to enhance educational performance, it is necessary to establish other budget redistribution criteria for FONACIDE, considering the need for infrastructure and the number of enrolled students per department

Abstract Introduction. Livestock farming with Creole cattle is practiced in rural areas with challenging characteristics for species management. Objective. To describe the production system and the socio-cultural and technical-economic factors affecting the production of Nunkiní Creole cattle (Bos taurus). Materials and methods. The study was conducted from November 2020 to October 2021 in nine livestock production units of Nunkiní, Calkiní municipality, Campeche, Mexico. Information was obtained from an interview form with social, cultural, technical, and economic study variables, applied to selected producers. Data were analyzed using descriptive statistics and ANOVA. Results. Livestock farming was carried out by men (100 %), with an average age of 58.44 years. The average years of experience were 34.61. Younger producers had higher levels of education and less experience, and were responsible for the production units of higher technological levels. The size of the livestock production unit ranged from five to twenty-two cattle (average of 14). Feeding management followed a transhumance scheme, with cattle being free-ranging on ejido lands and from May to December and semi-stabled from January to April, grazing on cultivated pastures and supplemented with agricultural residues. With the zootechnical management implemented by the producers, an average pregnancy rate of 83 % was achieved. The main product marketed was fresh meat in cuts and direct sale to consumers, with an average price of 2.675 USD$/kg. Conclusion. It is traditional extensive system that takes advantage of the common use of grasslands. It involves experienced but older producers, with small investments, and serves to strengthen their family economy. This activity is threatened by the lack of revaluation of Creole cattle and the introduction of exotic breeds in the area to maximize production.

Resumen Introducción. La ganadería con bovinos criollos se práctica en espacios rurales con características difíciles para el manejo de las especies. Objetivo. Describir el sistema productivo y los factores socioculturales y técnico-económicos que afectan la producción del bovino criollo de Nunkiní (Bos taurus). Materiales y métodos. El estudio se realizó entre noviembre del 2020 a octubre del 2021, en nueve unidades de producción pecuarias de Nunkiní en el municipio de Calkiní, Campeche, México. La información se obtuvo de una cédula de entrevista con variables de estudio sociales, culturales, técnicas y económicas, aplicada a productores seleccionados. Los datos se analizaron mediante estadística descriptiva y ANDEVA. Resultados. La crianza del ganado la realizaron hombres (100 %), con edad promedio de 58,44 años. Los años de experiencia promedio fueron de 34, 61. Los productores jóvenes tuvieron mayor escolaridad y menor experiencia, y se encargaron de las unidades de producción de mayor nivel tecnológico. El tamaño de la unidad de producción pecuaria varió de cinco a veintidós bovinos (media de 14). El manejo alimenticio tuvo un esquema de trashumancia, donde de mayo a diciembre estuvieron libres en tierras ejidales y de enero a abril se manejaron semiestabulados, con pastoreo en potreros cultivados y suplementados con residuos agrícolas. Con el manejo zootécnico implementado por los productores, se obtuvo un promedio de 83 % de preñez. El producto principal comercializado fue carne fresca en cortes y venta directa al consumidor, con un precio promedio de 2,675 USD$/kg. Conclusión. Es un sistema tradicional extensivo que aprovecha el uso común de los agostaderos. Con productores de experiencia, pero de edad avanzada, de pequeña inversión y le sirve para fortalecer su economía familiar. Dicha actividad se ve amenazada por la falta de revalorización del bovino criollo y la introducción de razas exóticas en la zona para maximizar la producción.

Abstract Introduction. Paraguay is the sixth largest producer and third largest exporter of soybeans (Glycine max (L.) Merr.) in the world and this crop is the most important socio-economic crop in the country. However, its productivity can be adversely affected by diseases caused by phytopathogenic fungi. In addition, phytosanitary information on soybean cultivation in Paraguay is limited. Objective. To understand farmers’ perceptions of the main soybean diseases and their management. Materials and methods. Between April and May 2022, a questionnaire in Google Forms format with open and closed-ended multiple-choice questions, was applied to 45 soybean producers aged between 30 and 50 years, who cultivate in areas between 200 to 1000 ha in the departments of Alto Paraná, Itapúa, and Caaguazú in Paraguay. Results. Among the respondents, 56% considered Asian soybean rust (Phakopsora pachyrhizi) as the most significant phytosanitary problem associated with soybean cultivation, followed by late-season diseases (LSD) such as brown spot (Septoria glycines) and frogeye leaf spot (Cercospora kikuchii). Respondents indicated taht they use three to four fungicide applications as a disease control measure, with their choice based on the type of product formulation. A majority of respondents noted that both the cost and frequency of applications increased over time. Additionally, 53% mentioned that biological fungicides are a viable alternative for integrated disease management. Conclusion. The responses obtained in this research allowed obtaining the perception of disease management tactics of soybean producers in Paraguay, underscoring the significance of Asian soybean rust and late-season diseases. However, there is a need for further research that can explore all aspects of pathogen management.

Resumen Introducción. Paraguay es el sexto productor y tercer exportador mundial de soja (Glycine max (L.) Merr.), este cultivo es el de mayor importancia socioeconómica en el país. Sin embargo, su productividad puede verse afectada por enfermedades causadas por hongos fitopatógenos. Además, la información fitosanitaria sobre el cultivo de soja en Paraguay es limitada. Objetivo. Comprender la percepción de agricultores sobre las principales enfermedades de la soja y su manejo. Materiales y Métodos. Entre abril y mayo de 2022, se aplicó un cuestionario en formato de formularios de Google con preguntas abiertas y cerradas de selección múltiple a 45 productores de soja de entre 30 y 50 años, quienes cultivan en superficies de entre 200 y 1000 ha en los departamentos de Alto Paraná, Itapúa y Caaguazú en Paraguay. Resultados. El 56 % de los encuestados consideró que el mayor problema fitosanitario asociado al cultivo es la roya asiática de la soja (RAS) (Phakopsora pachyrhizi), seguida por las enfermedades de final de ciclo (EFC), como la mancha marrón (Septoria glycines) y mancha ojo de rana (Cercospora kikuchii). Los entrevistados indicaron que utilizan de tres a cuatro aplicaciones de fungicidas como medida de control de enfermedades, su elección fue basada en el tipo de formulación de los productos. En su mayoría, los entrevistados señalaron que el costo y la cantidad de aplicaciones aumentó con el transcurso del tiempo. El 53 % mencionó que los fungicidas biológicos son una buena alternativa para el manejo integrado de enfermedades. Conclusión. Las respuestas obtenidas en esta investigación permitieron obtener la percepción de las tácticas de manejo de enfermedades de los productores de soja en Paraguay, lo que resaltó la importancia de la RAS y las EFC. No obstante, resulta necesario que se realicen más investigaciones que puedan explorar todos los aspectos del manejo de los patógenos.

Abstract Introduction. Coffee (Coffea spp.) is the second most traded product globally and is cultivated in over eighty countries. Its cultivation is complex because it belongs to an ecosystem where abiotic and biotic factors interact under various agronomic management conditions. To understand the development of the coffee plant and its influence on the sensory quality of the final product, it is necessary to explore the intricate interactions between the coffee plant and the native microorganisms within the crop environment. Objective. To describe the role of the coffee soil microbiota, specially bacteria and fungi, and how they may contribute to the final quality of the beverage. Development. Soil is one of the most diverse and least studied ecosystems, where crucial ecological functions for plant growth and development take place. Identifying soil microbial components and their interactions with other organisms is important from an agronomic perspective. The soil microbiota can enhance plant physiology; thus, this review aims to connect how the sensory attributes of coffee beverage can be positively influenced by soil microbiota. Articles from ScienceDirect, Scopus, Web of Science, and Google Scholar from 2011 to 2023 were reviewed. The data show the diversity of plant growth-promoting rhizobacteria (PGPR), nitrogen-fixing bacteria (NFB), and arbuscular mycorrhizal fungi (AMF) associated with coffee cultivation. Additionally, microbial compounds play an important role in the formation of sensory attributes and are related to the coffee cup quality. Conclusion. The microbial diversity of soil and on the fruit can synthesize or degrade compounds that affect the sensory profile of the coffee beverage, which could have implications for sustainability and quality.

Resumen Introducción. El café (Coffea spp.) es el segundo producto más comercializado a nivel mundial y cultivado en más de ochenta países. Su cultivo es complejo por pertenecer a un ecosistema donde factores abióticos y bióticos tienen dinámicas bajo diferentes condiciones de manejo agronómico. Para comprender el desarrollo de la planta y su influencia en la calidad sensorial del producto, hay que conocer la intrincada interacción entre la planta del café y los microorganismos autóctonos del cultivo. Objetivo. Describir el rol de la microbiota edáfica del café, bacterias y hongos, y cómo puede contribuir en la calidad final de la bebida. Desarrollo. El suelo es uno de los ecosistemas más diversos y menos estudiados, en el cual se desarrollan funciones ecológicas importantes para el crecimiento y desarrollo de las plantas. La identificación de los componentes microbianos del suelo y sus interacciones con otros organismos, son importantes desde el punto de vista agronómico. La microbiota edáfica puede favorecer la fisiología de la planta y de esta manera, se realiza la presente recopilación de información que busca asociar cómo los atributos sensoriales de la bebida de café pueden ser beneficiados por la microbiota del suelo. Se revisaron artículos de ScienceDirect, Scopus, Web of Science y Google Scholar, entre el 2011 y 2023. Los datos muestran la diversidad de rizobacterias promotoras del crecimiento vegetal (RPCV), bacterias fijadoras de nitrógeno (BFN) y hongos formadores de micorrizas arbusculares (HMA) asociados con el cultivo de café. También existen compuestos microbianos que juegan un papel importante en la formación de atributos sensoriales y están relacionados con la calidad en taza del café. Conclusión. La diversidad microbiana del suelo y fruto puede sintetizar o degradar compuestos que influyen en el perfil sensorial de la bebida, lo cual podría tener implicaciones para la sostenibilidad y calidad.

RESUMEN Las exportaciones de un país son clave para su economía. El objetivo de esta investigación es indagar sobre la contribución de las exportaciones no tradicionales al crecimiento económico del Paraguay a través del caso del sector alimenticio, durante el periodo 2011-2020. Para tal efecto, se planteó un diseño metodológico bibliográfico-documental, en el que se recurrió a un modelo econométrico que vinculaba el Producto Interno Bruto con las exportaciones tradicionales y no tradicionales del sector alimenticio junto con otras variables, para verificar sus efectos. Entre los principales resultados cabe señalar el efecto positivo de las exportaciones no tradicionales en el crecimiento de la economía y su potencial para diversificar la canasta exportadora del país. Clasificación JEL: F41, F43

ABSTRACT A country's exports are key to its economy. The objective of this research is to investigate the contribution of non-traditional exports to the economic growth of Paraguay through the case of the food sector, during the period 2011-2020. For this purpose, a bibliographical-documentary methodological design was proposed, in which an econometric model was used that linked the Gross Domestic Product with traditional and non-traditional exports of the food sector together with other variables, to verify its effects. Among the main results, it is worth noting the positive effect of non-traditional exports on the growth of the economy and its potential to diversify the country's export basket. JEL Classification: F41, F43.

ABSTRACT: Graphic communication projects begin with a strategic phase whose objective is to conceptualize a sensory universe that will be associated with the product or brand for which the project is developed. The objective is to emotionally connect the brand or product with the user. In this process, the "performativity" potential of images is used to define and communicate complex emotional qualities that are difficult to express through verbal language. Mostly, images are searched on the Internet and classified through hegemonic iconographic and iconological patterns. This article proposes to activate a critical look at the hybrid co-creation process that is generated between human and machine in the search for images on the net. Analyzing the agency of the non-human in this procedure will allow us to establish if the creative and methodological processes used contribute to establish and perpetuate a prevailing visual hegemony, or if they help to open fissures in its structure.

RESUMEN: Los proyectos de comunicación gráfica se inician con una fase estratégica cuyo objetivo es conceptualizar un universo sensorial que irá asociada al producto o marca para la cual se desarrolla el proyecto. El objetivo es conectar emocionalmente la marca o producto con el usuario. En este proceso se recurre al potencial de “performatividad” de las imágenes, para definir y comunicar cualidades emocionales complejas, difíciles de expresar a través del lenguaje verbal. Mayoritariamente, las imágenes se buscan en internet y son clasificadas mediante patrones iconográficos e iconológicos hegemónicos. Este artículo propone activar una mirada crítica sobre el proceso de co-creación híbrido que se genera entre humano y máquina en la búsqueda de imágenes en red. Analizar la agencia de lo no-humano en este procedimiento permitirá establecer si los procesos creativos y metodológicos usados contribuyen a establecer y perpetuar una hegemonía visual imperante, o si ayudan a abrir fisuras en su estructura.

Abstract In retail markets, analysis of perceived value in purchasing processes has been a topic of special interest as it focuses on perception of benefits beyond the product itself. In the face of such interest, an exhaustive bibliographical review was performed regarding its concept and components applied to retail dealers. The methodology is quantitative and cross-sectional, with a descriptive and explanative analysis through structural equation models to analyze the effect of dimensions in perceived value in the dependent variable of intent to purchase. Applied surveys on 390 recurring customers of retail dealers in Bogota. The results revealed that: functional value does have a positive effect on intent to purchase; and there is a relation between functional and symbolic value of purchase. The implications of management in the context of marketing are further discussed, focusing on functional value of a purchase. Actions related to quality, communication, employee training and customer service are recommended. These findings contribute to the literature on consumer behavior within the context of consumption by comparing functional and symbolic value.

Resumen En el ámbito del comercio minorista, el análisis del valor percibido en el proceso de compra ha sido objeto de especial interés por enfocarse en la percepción de beneficios que van más allá del producto en sí. Ante tal interés, se realizó una exhaustiva revisión bibliográfica sobre su concepto y componentes aplicado a establecimientos minoristas. La metodología es cuantitativa y transversal, con un análisis descriptivo y explicativo a través de modelos de ecuaciones estructurales para analizar el efecto de las dimensiones del valor percibido en la variable dependiente de la intención de compra. Se aplicaron encuestas a 390 a clientes habituales de comercios minoristas en Bogotá. Los resultados revelaron que el valor funcional tiene un efecto positivo en la intención de compra; y existe una relación entre el valor funcional y el valor simbólico de la compra. Se discuten las implicaciones de la gestión en el ámbito del marketing, centrándose en el valor funcional de la compra. Se sugieren acciones relacionadas con la calidad, la comunicación, la capacitación de los empleados y el servicio al cliente. Estos hallazgos contribuyen a la literatura sobre el comportamiento del consumidor en el contexto del consumo, al comparar el valor funcional y el valor simbólico.

Resumo Dentro do âmbito do comercio de retalho, a análise do valor percebido no processo de compra tem sido objeto de interesse especial por se focalizar em a percepção de benefícios que vão mais longe do produto direito. Com esse interesse, fez-se uma revisão exaustiva da literatura de seu conceito e componentes aplicados aos estabelecimentos de retalho. A metodologia é quantitativa e transversal, com uma análise descritiva e explicativa por meio de modelos de equações estruturares para analisar o efeito das dimensões do valor percebido na variável dependente da intenção de compra. Fizeram-se pesquisas em 390 clientes usuais de lojas de retalho em Bogotá. Os resultados revelaram que: o valor funcional tem um efeito positivo na intenção de compra; e existe uma relação entre o valor funcional e o valor simbólico da compra. Discutem-se as implicações da gestão no âmbito do marketing, focalizando-se no valor funcional da compra. Sugerem-se ações relacionadas à qualidade, comunicação, capacitação dos empregados y serviço ao cliente. Os resultados contribuem à literatura com relação ao comportamento do consumidor no contexto do consumo, ao comparar o valor funcional e o valor simbólico.

RESUMEN La industria del tabaco, como cualquier otra, es participe del producto interno bruto y la generación de empleo en cualquier país. No obstante, los gobiernos han establecido mecanismos fiscales para erradicar su consumo, debido a las enfermedades que ocasiona como cáncer pulmonar, bronquitis crónica; lo que puede llevar a la muerte. En este sentido, se propone una aplicación de un modelo de externalidades para la producción de tabaco en México. Se obtuvieron dos mecanismos para la erradicación del tabaco, uno de ellos implica que las empresas disminuyan salarios de los trabajadores por el aumento de impuestos; el segundo, aumentar precios del tabaco permitiendo que las empresas equilibren su presupuesto. Ambos mecanismos implican un desajuste presupuestal para los ciudadanos, pero el segundo es una solución socialmente optima, pues solo se ven afectados los consumidores de tabaco y no así los que dependen del empleo y salario de la empresa.

ABSTRACT The tobacco industry, like any other, is a participant in the gross domestic product and the generation of employment in any country. However, governments have established fiscal mechanisms to eradicate its consumption, due to the diseases it causes such as lung cancer, chronic bronchitis; what can lead to death. In this sense, an application of an externalities model for tobacco production in Mexico is proposed. Two mechanisms were obtained for the eradication of tobacco; one of them implies that companies reduce workers' wages due to the increase in taxes. A second is to increase tobacco prices allowing companies to balance their budget. Both mechanisms imply a budget imbalance for citizens, but the second is a socially optimal solution, since only tobacco users are affected and not those who depend on the company's employment and salary.

RESUMEN Este trabajo tiene por objetivo presentar un método de evaluación y análisis de la cadena de suministro como estructura organizativa cuya salida es un producto de calidad y alta demanda en el sector agropecuario. Se presentan definiciones, así como los elementos que definen a la cadena de suministro como estructura organizativa. Se brinda un método de evaluación y análisis, estableciendo sus dimensiones de trabajo y las etapas para su desarrollo. Su aplicación práctica permite realizar una síntesis de los factores que entorpecen y/o facilitan la efectividad de la cadena en el contexto de la economía cubana. Se expone el resultado del proyecto de investigación «Mejorar la cadena de suministro de productos cárnicos del sector agroalimentario para la exportación en fronteras. Código: PN131SS014-011», perteneciente a un Programa Nacional de Ciencia y Técnica.

ABSTRAC This work aims to present a method of evaluation and analysis of the supply chain as an organizational structure whose output is a quality product and high demand in the agricultural sector. Definitions are presented, as well as the elements that define the supply chain as an organizational structure. An evaluation and analysis method is provided, establishing its dimensions of work and the stages for its development. Its practical application allows a synthesis of the factors that hinder and/or facilitate the effectiveness of the chain in the context of the Cuban economy. The result of the research project «Improving the supply chain of meat products in the agri-food sector for export at borders Code PN131SS014-011», belonging to add files National Program of Science and Technique