Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the brain, and inhibiting this enzyme can reduce oxidative stress, stabilize neurotransmitter levels, and alleviate symptoms. In this context, a pharmacophoric model was created using PharmaGist with 31 hits extracted from BindingDB to enable a pharmacophoric-based search of potential MAO-B inhibitors in ZincPharmer’s chemical space, followed by the building of 10 conformers for each molecule in the software OMEGA, screening for structural and electrostatic similarity to safinamide using ROCS (Rapid overlay of chemical structures) and EON (Electrostatic similarity for lead-hopping), respectively. In addition, the molecular docking with Gold using the score function was performed to rank the ligands with the highest probabilities of affinity to MAO-B and then discriminate those with suitable physical chemical, pharmacokinetic, and toxicological features using the tools QikProp, SwissADME, and DEREK. Four potential ligands with selective MAO-B inhibitor properties were identified, which show promise as future therapeutic agents for MAO-B-related disorders. Worldwide schizophrenia depression diseases MAOB MAO (MAO-B brain stress levels symptoms context 3 pharmacophoricbased based ZincPharmers ZincPharmer s space 1 OMEGA Rapid structures Electrostatic leadhopping, leadhopping lead hopping , lead-hopping) respectively addition pharmacokinetic QikProp SwissADME DEREK identified MAOBrelated related disorders lead-hopping

Abstract This research analyzes how individual characteristics (area of origin, skin color, economic status of origin and education) and structural factors (economic growth and trade openness) influence in Mexico the opportunities to obtain a high level of economic well-being. Using a IV-probit model estimated in two stages with instrumental variables in a context of complex samples, it is identified that people born in homes with low economic status, originating from rural localities and with brown skin have lower probabilities of economic success compared to people of non-low economic status, from urban areas and light skin. The findings also reveal that economic growth and educational achievement increase the probabilities of obtaining a high economic status, but the increase in probabilities is bigger for people of non-low economic origin, coming from urban areas and light skin. Finally, through the different rates of growth and school achievement, the differences in economic well-being widen, which indicates an increase in inequality between privileged and non-privileged groups. This research is innovative since it not only analyzes the effect of economic growth and academic achievement on social mobility, but also provides an empirical method that investigates the effect of growth and academic achievement on inequality of opportunities for socioeconomic advancement. The results indicate the existence of irrational mobility barriers based on criteria over which the individual has no control.

Resumen La presente investigación analiza cómo influyen en México las características del individuo (ámbito de origen, color de piel, estatus económico de origen y educación) y los factores estructurales (crecimiento económico y apertura comercial) en las oportunidades de obtener un nivel de bienestar económico alto. Por medio de un modelo probit, estimado en dos etapas con variables instrumentales en un contexto de muestras complejas, se identifica que las personas nacidas en hogares con estatus económico bajo, originarias de localidades rurales y de piel morena, tienen menores probabilidades de éxito económico con respecto a las personas de estatus de origen económico no-bajo, provenientes del ámbito urbano y piel clara. Los hallazgos también revelan que el crecimiento económico y el logro escolar aumentan las probabilidades de obtener un estatus económico alto, pero el incremento de probabilidades no es homogéneo, sino que favorece en mayor medida a personas de origen económico no-bajo, provenientes del ámbito urbano y piel clara. Finalmente, se identifica que, a través de las distintas tasas de crecimiento y logro escolar, las diferencias en el bienestar económico se amplían, lo que indica aumento de la desigualdad entre grupos privilegiados y no-privilegiados. La ruta de investigación es innovadora ya que no solo analiza el efecto del crecimiento económico y el logro académico en la movilidad social, sino que también aporta un método empírico que indaga el efecto del crecimiento y el logro académico en la desigualdad de oportunidades de ascenso socioeconómico. Los resultados indican la existencia de barreras de movilidad irracionales basadas en criterios sobre los que el individuo no tiene control.

BACKGROUND. Adolescent girls and young women (AGYW) remain vulnerable to HIV, with a higher incidence rate than their male counterparts. OBJECTIVES. To determine the prevalence of and factors associated with HIV testing among AGYW in South Africa (SA). METHODS. A cross-sectional design was used to analyse the South Africa Demographic and Health Survey 2016. Only sexually active AGYW aged 15 - 24 years residing in SA at the time of the survey were included. Descriptive statistics were used to analyse baseline sociodemographic characteristics. Univariate and multivariate logistic regression models were used to determine factors associated with HIV testing. Statistical significance was set at p<0.05, and all analyses were adjusted using survey weights to account for unequal selection probabilities. RESULTS. The overall prevalence of HIV testing among sexually active AGYW was 85.2% (95% confidence interval (CI) 83.0 - 87.1). The AGYW who had a history of pregnancy (adjusted odds ratio (aOR) 4.47; 95% CI 2.90 - 6.89), were employed (aOR 3.29; 95% CI 1.75 - 6.21), belonged to a middle wealth index (aOR 1.80; 95% CI 1.04 - 3.10), had knowledge about mother-to-child transmission of HIV (aOR 3.29; 95% CI 2.26 - 4.79), had visited a health facility during the past 12 months (aOR 2.93; 95% CI 2.09 - 4.10), or had secondary/tertiary education (aOR 2.04; 95% CI 1.04 - 3.99) had higher odds of HIV testing. CONCLUSION. The study identified an unmet need for HIV testing among sexually active AGYW in SA, especially adolescent girls aged 15 - 19 years. Increasing knowledge about HIV testing, adolescent-friendly services and other offsite strategies are therefore important for this particular key population.

Abstract: Research on the economic valuation of temples or religious heritage is scarce and, at the same time, extremely necessary, given the growing importance of religious tourism in certain territories with significant static competitive advantages that can be economically exploited. This article quantifies the economic value of the Sanctuary of Nuestra Señora de Las Lajas, Colombia, declared of national cultural interest by the Ministry of Culture in 2006, by adapting and applying travel cost and contingent valuation methods, as well as Poisson, logit, and probit regression models to estimate the probabilities of visiting the temple and the willingness to pay of religious consumers (WTP). The probability of visiting the Sanctuary is explained by the WTP and the visitor's postgraduate education and, in turn, the WTP is determined by the final consumption expenditure, the number of visits made and the salaried status of the tourist. The logit and probit regressions predict a highly significant payment probability of 97.5%.

Resumen: Las investigaciones de valoración económica de templos o patrimonio religioso son escasas y, a la vez, sumamente necesarias, dada la importancia creciente del turismo religioso en ciertos territorios con apreciables ventajas competitivas estáticas susceptibles de explotación económica. En este artículo se cuantifica el valor económico del Santuario de Nuestra Señora de Las Lajas, Colombia (declarado bien de interés cultural nacional por el Ministerio de Cultura en 2006), mediante la adaptación y aplicación de los métodos de costo de viaje y valoración contingente, así como modelos de regresión de Poisson, logit y probit en la estimación de las probabilidades de visitar el templo y la voluntad de pago de los consumidores religiosos (DAP). La probabilidad de visitar el Santuario es explicada por la DAP y la formación posgradual del visitante y, a su vez, la DAP es determinada por el gasto en consumo final, el número de visitas realizadas y la condición de asalariado del turista. Las regresiones logit y probit predicen una probabilidad de pago muy significativa de 97.5 %. Clasificación JEL: D46; D62; Z1; Z12

Resumen: En el presente estudio, se analiza el desempeño sísmico de un sistema dual de hormigón armado (pórticos y muros especiales) con diferentes niveles de irregularidad torsional. Se plantean tres arquetipos, cada uno con un nivel de irregularidad torsional distinto (IT 1.0, IT 1.2 e IT 1.4) con la finalidad de evaluar el efecto de la irregularidad torsional en el desempeño sísmico. Los elementos estructurales de los arquetipos cumplen con el diseño sismorresistente. Además, se tomó en cuenta los factores de sobre-resistencia y amplificación dinámica para determinar el corte de diseño en los muros estructurales. Se realizaron análisis estático y dinámicos no lineales para cuantificar las respuestas globales y locales de cada uno de los modelos. Los modelos analíticos de muros estructurales son calibrados en función de los datos obtenidos en ensayos experimentales existentes, de esta manera se valida los elementos tipo fibra (infrmFB) usados y los parámetros de los modelos constitutivos de los materiales. Se realizan análisis dinámicos incrementales (IDA) para cada uno de los arquetipos con los once registros sísmicos seleccionados de la base del PEER. Las curvas IDA son desarrolladas con dos parámetros de demanda ingenieril: derivas de piso y deformaciones unitarias. Finalmente, se elaboran las curvas de fragilidad para los niveles de desempeño de ocupación inmediata, seguridad de vida y prevención de colapso, y se determinan los coeficientes de margen con la finalidad de cuantificar las probabilidades de alcanzar los niveles de desempeño mencionados.

Abstract: This research evaluates the seismic performance of a dual reinforced concrete system with different levels of torsional irregularity. Three archetypes are proposed, each of them with a different level of torsional irregularity (IT 1.0, IT 1.2 and IT 1.4) in order to evaluate the effect of torsional irregularity on seismic performance. The structural elements of the archetypes comply with the seismic design. In addition, the factors of overstrength and dynamic amplification were considered to determine the design shear force in the structural walls. Linear static and nonlinear dynamic analysis were performed to quantify the global and local responses of each of the models. The analytical models of structural walls are calibrated based on the data of existing experimental tests, thus validating the fiber-type elements (infrmFB) used and the parameters of the constitutive models of the materials. Incremental dynamic analysis (IDA) is performed for each of the archetypes with the eleven seismic records selected from the PEER database. IDA curves are developed with two engineering demand parameters: story drifts and strains. Finally, the fragility curves are elaborated for the immediate occupancy, life safety, and collapse prevention performance levels, and the margin ratio are determined to quantify the probabilities of reaching a certain level of performance.

RESUMEN Fundamento: los métodos de construcción de escenarios son de gran importancia para el logro de cualquier meta ya que permiten a los actores sociales participar en la construcción del futuro deseado al conjeturar las realidades que aún no han sucedido pero que podrían acontecer si se anticipa la acción. Objetivo: elaborar escenarios prospectivos de tipo exploratorio para el fomento de mayores niveles de responsabilidad personal con la salud en Cuba en un horizonte hasta el año 2030. Métodos: estudio de prospectiva estratégica desde enero 2018 a marzo 2020 con la aplicación del método de Sistemas y Matrices de Impactos Cruzados y el software LIPSOR-EPITA- SMIC-Prob-Expert ®. Se seleccionaron 16 expertos que evaluaron las probabilidades de ocurrencia simples y condicionadas de seis hipótesis que representaban futuros posibles. Resultados: se obtuvo un total de 64 escenarios de los cuales diez fueron considerados escenarios tendenciales. Se escogió como escenario apuesta el nombrado “Aceptar los cambios, gestionar los desafíos, integrar el proceso”, que configura una narrativa con el cumplimiento de cinco de las seis hipótesis evaluadas. Conclusiones: la aplicación del método de Sistemas y Matrices de Impactos Cruzados permitió elaborar los posibles escenarios futuros que deben ser desafiados para el fomento de mayores niveles de responsabilidad personal con la salud en Cuba en un horizonte hasta el año 2030. Se propone culminar el ejercicio de prospectiva estratégica valorando los principios de política, estrategias y acciones a incluir en una política o plan de acción estratégico para alcanzar el escenario apuesta.

ABSTRACT Foundation: scenario construction methods are of great importance for the achievement of any goal since they allow social actors to participate in the construction of the desired future by conjecturing the realities that have not yet happened but that could happen if the action is anticipated. Objective: to develop prospective, exploratory scenarios to promote higher levels of personal responsibility with health in Cuba until 2030. Methods: strategic prospective study from January 2018 to March 2020 with the application of the Cross Impact Systems and Matrices method and the LIPSOR-EPITA-SMIC-Prob-Expert ® software. 16 experts were selected who evaluated the simple and conditional probabilities of occurrence of six hypotheses that represented possible futures. Results: a total of 64 scenarios were obtained, of which ten were considered trend scenarios. The chosen scenario was “Accept the changes, manage the challenges, integrate the process”, which form a narrative with the fulfillment of five of the six hypotheses evaluated. Conclusions: the application of the Cross Impact Systems and Matrices method allowed elaborate possible future scenarios that must be challenged to promote higher levels of personal responsibility with health in Cuba on a horizon until the year 2030. It is proposed to complete the exercise of strategic foresight, assessing the policy principles, strategies and actions to be included in a policy or strategic action plan to achieve the target scenario.

Abstract In Early Christianity the miraculous charisma of discretio spirituum was exercised with great freedom by many holy men and women who managed to avoid the constraints of the institutional Church. From the end of the Middle Ages, on the contrary, the gift of discernment came under the full control of the official religion: charismatic religiosity began to lose from then on much of the autonomy and freedom it had enjoyed for centuries. Finally, from the end of the early modern period, the charisma of probatio spirituum disappeared without too much ado from the official discourse, which from then on only alluded to the art of discernment understood as a collectively constructed human know-how, based on probabilities and conjectures, oblivious to all pretense of infallibility and incapable of forcing believers to compulsively embrace the conclusions reached by ecclesiastical authorities.

Resumen Durante el primer milenio cristiano el fabuloso carisma de discretio spirituum fue ejercido con amplia libertad por muchos santos que lograron trascender las constricciones de la Iglesia institucional. Desde fines de la Edad Media, por el contrario, el don de discernimiento fue sometido al pleno control de la religión oficial: la religiosidad carismática comenzó a perder a partir de entonces gran parte de la autonomía y libertad que había gozado durante siglos. Finalmente, desde fines de la Edad Moderna el carisma de la probatio spirituum desapareció sin demasiados preámbulos del discurso oficial, que solamente aludió de allí en más al arte de discernir entendido como un know how terrenal, colectivamente construido, sustentado en probabilidades y conjeturas, ajeno a toda pretensión de infalibilidad y que no obliga a los creyentes a abrazar de manera compulsiva las conclusiones a las que el orden sacerdotal arriba.

Abstract This research seeks to analyze the results of the application of latent class analysis model in the variables of job satisfaction and organizational commitment. It was used a questionnaire in which it was obtained a sample of 528 employees. One of the main results of the analysis is that three categories of workers were gotten for each variable, that is, high/moderate/low job satisfaction and low/medium/high organizational commitment. Each category differs from the others in terms of the probability of response of each behavior orl intention to behave. The results show that, both in the public and private sector, workers with low levesl of job satisfaction are characterized by having low levels in all dimensions, mainly in satisfaction with recognition (79.5% and 100%, respectively), and regarding organizational commitment, those who have a low level in general, have higher probabilities of being in a low level in each of its three dimensions.

Resumen Esta investigación busca analizar los resultados de la aplicación de un modelo de análisis de clases latentes en las variables satisfacción laboral y compromiso organizacional. Se aplicó un cuestionario del cual se obtuvo una muestra de 528 empleados. Uno de los principales resultados del análisis es que se obtuvieron tres categorías de trabajadores para cada variable, esto es, satisfacción laboral alta/moderada/baja y compromiso organizacional bajo/medio/alto. Cada una de las categorías se diferencia de las otras en función de la probabilidad de respuesta de cada conducta o intención de comportamiento. Se presenta en los resultados que, tanto en el sector público como privado, los trabajadores con nivel bajo de satisfacción laboral se caracterizan por tener niveles bajos en todas las dimensiones, principalmente en la satisfacción con el reconocimiento (79,5% y 100% respectivamente), y respecto al compromiso organizacional, quienes tienen un nivel bajo en general tienen probabilidades más altas de estar en un nivel bajo en cada una de sus tres dimensiones.

ABSTRACT Introduction: The impact of mitral regurgitation (MR) on valve-in-valve transcatheter aortic valve implantation (VIV-TAVI) in patients with failed bioprostheses remains unclear. The purpose of this study was to assess the prognostic impact of residual moderate MR following VIV-TAVI. Methods: We retrospectively analyzed 127 patients who underwent VIV-TAVI between March 2010 and November 2021. At least moderate MR was observed in 51.2% of patients before the procedure, and MR improved in 42.1% of all patients. Patients with postoperative severe MR, previous mitral valve intervention, and patients who died before postoperative echocardiography were excluded from further analyses. The remaining 114 subjects were divided into two groups according to the degree of postprocedural MR: none-mild MR (73.7%) or moderate MR (26.3%). Propensity score matching yielded 23 pairs for final comparison. Results: No significant differences were found between groups before and after matching in early results. In the matched cohort, survival probabilities at one, three, and five years were 95.7% vs. 87.0%, 85.0% vs. 64.5%, and 85.0% vs. 29.0% in the none-mild MR group vs. moderate MR-group, respectively (log-rank P=0.035). Among survivors, patients with moderate MR had worse functional status according to New York Heart Association (NYHA) class at follow-up (P=0.006). Conclusion: MR is common in patients with failed aortic bioprostheses, and improvement in MR-status was observed in over 40% of patients following VIV-TAVI. Residual moderate MR after VIV-TAVI is not associated with worse early outcomes, however, it was associated with increased mortality at five years of follow-up and worse NYHA class among survivors. Introduction (MR valveinvalve VIVTAVI VIV TAVI (VIV-TAVI unclear VIVTAVI. TAVI. Methods 12 201 2021 512 51 2 51.2 procedure 421 42 1 42.1 intervention analyses 11 nonemild none mild 73.7% 737 73 7 (73.7% 26.3%. 263 26.3% . 26 3 (26.3%) comparison Results results cohort one three 957 95 95.7 vs 870 87 0 87.0% 850 85 85.0 645 64 5 64.5% 290 29 29.0 MRgroup, MRgroup group, MR-group logrank log rank P=0.035. P0035 P P=0.035 035 P=0.035) survivors (NYHA followup follow up P=0.006. P0006 P=0.006 006 (P=0.006) Conclusion MRstatus 40 outcomes however 20 202 51. 4 42. 73.7 (73.7 26.3 (26.3% 9 95. 8 87.0 85. 6 64.5 29. P003 P=0.03 03 P000 P=0.00 00 (P=0.006 73. (73. 26. (26.3 87. 64. P00 P=0.0 (P=0.00 (73 (26. P0 P=0. (P=0.0 (7 (26 P=0 (P=0. ( (2 P= (P=0 (P= (P

Abstract Design loads for parking garages should be reviewed every few years due to changes in fleet characteristics and the impact of design loads on carbon emissions by the built environment. Specifically for Brazil, the authors are unaware of existing studies to justify the design values and corresponding exceedance probabilities stated in NBR 6120:2019 - Design Loads for Structures. In this paper, a simplified probabilistic model for live loads in parking garages is presented. A set of updated statistics characterizing the gross curb weight of the fleet in circulation was obtained based on technical specifications and sales reports between 2003 and 2022. These statistics and the probabilistic load model are employed to derive the equivalent uniform design load corresponding to a 30% probability of being exceeded in 50 years, according to the definition stated in NBR 6120:2019 and NBR 8681:2003. The results provide support for a significant reduction of the current design load for light-duty vehicle parking garages, from the current 3.0 kN/m2 to at least 2.5 kN/m2. Such a reduction has a significant impact on new building construction costs and carbon emissions and would not compromise the structural safety of parking garages built in Brazil. environment Brazil 61202019 6120 2019 6120:201 Structures paper presented 200 2022 30 5 86812003. 86812003 8681 2003. 8681:2003 lightduty light duty 3 0 3. kNm2 kNm kN m2 m kN/m 25 2 2. 6120201 612 201 6120:20 20 202 8681200 868 8681:200 612020 61 6120:2 868120 86 8681:20 61202 6 6120: 86812 8 8681:2 8681:

Resumo Cargas de projeto para garagens devem ser periodicamente revisadas em função de mudanças nas características da frota de veículos, bem como devido ao impacto nas emissões de carbono do ambiente construído. Especificamente no caso do Brasil, os autores desconhecem estudos que justifiquem os valores de projeto e as probabilidades de excedência preconizados na NBR 6120:2019 - Ações para o cálculo de estruturas de edificações. Neste artigo, um modelo estocástico simplificado para cargas variáveis em garagens e estacionamentos é apresentado. Com base nas especificações técnicas dos veículos e em dados de vendas entre 2003 e 2022, foram obtidas estatísticas para caracterizar os pesos operacionais da frota de veículos em circulação. Estas estatísticas e o modelo probabilístico são utilizados para obter a carga uniforme equivalente que corresponde à probabilidade de 30% de ser ultrapassada em 50 anos, conforme a definição da NBR 6120:2019. Os resultados obtidos fornecem suporte para uma redução na carga de projeto para garagens, dos atuais 3.0 kN/m2 para pelo menos 2.5 kN/m2. Tal redução teria um impacto significativo no custo de novos edifícios-garagem/estacionamentos subterrâneos, bem como nas emissões de carbono, sem comprometer a segurança destas estruturas. construído Brasil 61202019 6120 2019 6120:201 edificações artigo apresentado 200 2022 circulação 30 5 anos 61202019. 2019. 3 0 3. kNm2 kNm kN m2 m kN/m 25 2 2. edifíciosgaragem/estacionamentos edifíciosgaragemestacionamentos edifícios garagem/estacionamentos garagem subterrâneos 6120201 612 201 6120:20 20 202 edifíciosgaragem garagemestacionamentos 612020 61 6120:2 61202 6 6120:

Abstract In this paper, an analysis is conducted on the adolescent population aged 15 to 17 years who work in the state of Jalisco in Mexico. The two main factors considered as negative impacts of adolescent work are analyzed: the impact on school dropout and employment under risky conditions. Using the ENTI 2019 (National Survey of Child Labour) we describe and analyze the employment rates in this population group, considering differences in gender, age, and size of the locality in which they reside, and their relationship and effect on school attendance and the probability of working under risky conditions. Most of the findings are consistent with the existing empirical literature, but it is worth noting that in this case the probabilities of working under risky conditions and dropping out of school do not necessarily have a monotonic relationship with age, and present differences in their trends depending on the size of the locality in which the adolescents reside.

Resumen En este artículo se hace un análisis de la población adolescente de 15 a 17 años que trabaja, en el estado Jalisco en México. Se analizan los dos principales factores que se consideran impactos negativos del trabajo adolescente: el impacto en el abandono escolar y el empleo en condiciones de riesgo. A partir de los datos de la Encuesta Nacional de Trabajo Infantil 2019 (ENTI 2019), se describen y analizan las tasas de empleo en este grupo poblacional, considerando diferencias de sexo, edad y tamaño de la localidad en la que se habita, y su relación y efecto sobre la inasistencia escolar y la probabilidad de trabajar en condiciones de riesgo. La mayoría de los hallazgos son consistentes con gran parte de la literatura empírica existente, pero destaca que las probabilidades de trabajar en condiciones de riesgo y de abandono escolar no tiene necesariamente una relación monótona con la edad, y presentan diferencias en sus tendencias dependiendo el tamaño de la localidad en la que habiten los adolescentes.

Abstract Introduction Pregnancy and diabetes mellitus promote several musculoskeletal changes predisposing this population to complaints of Lower Back (LB) and Pelvic Pain (PP). Objective To assess the frequency of LB and PP and associated factors in type 1 Diabetic (DM1) pregnant women. Method: An observational analytical cross-sectional study. Thirty-six pregnant women with DM1 were evaluated through a postural assessment with a focus on pelvic positioning and what patients reported. The associated factors were assessed using the State-Trait Anxiety Inventory (STAI), the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), and the Female Sexual Function Index (FSFI). Results The frequency of LB and PP was 55.6 % and 30.6 %, respectively. The presence of anxiety was not associated with a higher prevalence of pain. The incidence of sexual dysfunctions was higher in the GD. DM1 duration had a mean of 14.9 years (± 8.2 SD) in the GD and 9.0 years (± 6.9 SD) in the GSD, which was statistically significant (p ≤ 0.050). In the multiple binary regression analysis for the occurrence of pain, the independent factor was DM1 duration ≥ 17 years (OR = 11.2; 95 % CI = 1.02‒124.75). The association between DM1 duration ≥ 17 years and being overweight showed a probability of 95 % for the studied population in the analysis of the probabilities of occurrence of the pain event. Conclusion There was a high frequency of LB and PP related to pregnancy in DM1 pregnant women in the second trimester of pregnancy. The incidence of sexual dysfunction and DM1 duration ≥ 17 years increases the chance that DM1 pregnant women will experience pain. There was no association between anxiety. urinary incontinence and pain in DM1 pregnant women. (LB PP. . (PP) DM (DM1 Method crosssectional cross sectional study Thirtysix Thirty six reported StateTrait State Trait STAI, STAI , (STAI) ICIQSF, ICIQSF ICIQ SF (ICIQ-SF) FSFI. FSFI (FSFI) 556 55 6 55. 306 30 30. respectively 149 14 9 14. ± ( 82 8 2 8. SD 90 0 9. 69 6. GSD p 0.050. 0050 0.050 050 0.050) OR 11.2 112 11 1.02‒124.75. 10212475 1.02‒124.75 02 124 75 1.02‒124.75) event (PP (DM (STAI (ICIQ-SF (FSFI 5 3 005 0.05 05 11. 1021247 1.02‒124.7 12 7 00 0.0 102124 1.02‒124. 0. 10212 1.02‒124 1021 1.02‒12 102 1.02‒1 10 1.02‒ 1.02 1.0 1.

ABSTRACT The concept of a swarm of drones assumes the presence of a wireless ad hoc network, in which drones are network nodes and exchanging information with each other. This article is devoted to studying the behavior of an ad hoc network in a transient mode and assessing the characteristics of updating local adjacency matrices (LAM), which allow network nodes to autonomously form packet transmission routes. Using a simulation model, a comparison was made of two multiple access methods to a common data transmission channel in the process of updating matrices: cyclic and random (slotted ALOHA). The simulation results made it possible to determine areas of their effective application: slotted ALOHA is advisable to use with relatively high probabilities of packet distortion (of the order of 0.1 and higher), a numerous nodes (more than 40), and low network connectivity, and cyclic access (CA) is effective at a low level of distortion. It is shown that the completion of the process of updating adjacency matrices (AM) can be judged by such indicators of the exchange of routing information as the achievement of a certain threshold of the number of transmissions and a decrease in the level of network traffic. other LAM, LAM , (LAM) routes model ALOHA. . ALOHA) application 01 0 1 0. higher, higher higher) more 40, 40 40) connectivity CA (CA AM (AM traffic (LAM 4

RESUMO: Este artigo se propõe a analisar a desarticulação entre a oferta e a demanda por conhecimento nas regiões brasileiras, utilizando como proxy a oferta de mão de obra e a sua inserção nos setores produtivos de acordo com a classificação de intensidade tecnológica da Organização para Cooperação e Desenvolvimento Econômico. São utilizados os dados da Pesquisa Nacional por Amostra de Domicílios Contínua do Instituto Brasileiro de Geografia e Estatística para o período de 2012 a 2019, e são estimados modelos logit multinomial para dados empilhados para o período com o objetivo de mensurar diferenças nas probabilidades de absorção dos trabalhadores ocupados em setores de baixa, média e alta intensidade tecnológica. Os resultados indicam que avanços no grau de qualificação formal reduzem a probabilidade de absorção em setores de baixa intensidade tecnológica, ao mesmo tempo em que aumentam as chances de inserção em setores de média e alta intensidades tecnológicas. As disparidades regionais evidenciam que a concepção de uma política que tenha como objetivo o fomento da inovação requer o desenho de instrumentos que estimulem de forma concreta o aumento da demanda por conhecimento. RESUMO brasileiras Econômico 201 2019 tecnológicas 20 2

ABSTRACT: This study aims to analyze the disconnection between the supply and demand for knowledge in Brazilian regions, using labor supply and its integration into productive sectors according to the OECD technological intensity classification as a proxy. Data from Pesquisa Nacional por Amostra de Domicílios Contínua (PNAD Contínua) by IBGE for the period from 2012 to 2019 were used, and logit-multinomial models for stacked data were estimated for this period to measure differences in the probabilities of workers being absorbed into low, medium, and high technological intensity sectors. Results indicate that advancements in formal qualifications reduce the probability of absorption in low technological intensity sectors and increase the chances of insertion in medium and high technological intensity sectors. Regional disparities highlight that the design of a policy aimed at fostering innovation requires the creation of concrete instruments that stimulate increased demand for knowledge. ABSTRACT regions proxy PNAD 201 used logitmultinomial logit multinomial 20 2

Abstract The advent of information and communication technologies can lead to imbalances between labor supply and demand. Recent studies indicate that in Brazil, one of the sectors most likely to be affected by automation processes is agriculture. The objective is to investigate the factors that influence job retention in the agricultural sector, introducing an innovative explanatory factor: the probabilities of automation associated with different occupations, as proposed by Frey & Osborne (2013) and adapted to the Brazilian labor market by Lima et al. (2019). Our analysis used data from RAIS 2019. The results highlight that seniority and remuneration have a positive impact on the probability of an individual remaining employed. However, workers in occupations with a high probability of automation face an expected probability 6.66% lower to retain their jobs compared to those in low-probability automation occupations. Additionally, individuals with a degree have an 11.21% higher probability of maintaining employment compared to those with only a fundamental education. It is concluded that the estimates reinforce the need for investments in professional qualifications to provide workers with skills aligned with the contemporary agricultural needs. demand Brazil agriculture sector factor 2013 (2013 al 2019 . (2019) employed However 666 6 66 6.66 lowprobability low Additionally 1121 11 21 11.21 education needs 201 (201 (2019 6.6 112 1 2 11.2 20 (20 6. 11. (2 (

Resumo O advento das tecnologias de informação e comunicação pode ocasionar desajustes entre a oferta e a demanda de força de trabalho. Estudos recentes evidenciam que, no Brasil, um dos setores que tendem a ser mais impactados por processos de automação é o setor da agropecuária. O objetivo é investigar os fatores que influenciam a manutenção do emprego no setor agropecuário, introduzindo um fator explicativo inovador: as probabilidades de automação associadas a diferentes ocupações, conforme proposto por Frey & Osborne (2013), e adaptadas ao mercado de trabalho brasileiro por Lima et al. (2019). Na análise, utilizam-se os dados da RAIS de 2019. Os resultados apontam que o tempo de vínculo e a remuneração exercem um impacto positivo na probabilidade de um indivíduo permanecer empregado. No entanto, ocupações com alta probabilidade de automação apresentam uma probabilidade esperada 6,66% menor de manutenção do emprego para os trabalhadores quando comparadas às ocupações de baixa probabilidade de automação. Adicionalmente, indivíduos com graduação apresentam uma probabilidade 11,21% maior de manter o emprego em comparação com aqueles com apenas o ensino fundamental. Conclui-se que as estimativas reforçam a necessidade de investimentos em qualificação profissional para dotar os trabalhadores de habilidades alinhadas às necessidades da agropecuária contemporânea. Brasil agropecuário inovador 2013, 2013 , (2013) al 2019 . (2019) análise utilizamse utilizam se empregado entanto 666 6 66 6,66 Adicionalmente 1121 11 21 11,21 fundamental Concluise Conclui contemporânea 201 (2013 (2019 6,6 112 1 2 11,2 20 (201 6, 11, (20 (2 (