Resumen: El objetivo de este estudio fue evaluar la prevalencia de fenotipos corporales y sus asociaciones con biomarcadores de perfiles lipídicos, glucídicos e inflamatorios. Se trata de un estudio transversal, de base poblacional, realizado con 720 individuos de entre 20 y 59 años. La composición corporal se evaluó mediante absorciometría de rayos X de energía dual. La obesidad se estimó como porcentaje de grasa corporal ≥ 25% en hombres y ≥ 32% en mujeres, y la sarcopenia como índice de masa muscular apendicular < 7,0kg/m2 en hombres y < 5,5kg/m2 en mujeres. La obesidad sarcopénica se evaluó como la coexistencia de sarcopenia y obesidad. Las prevalencias de obesidad, sarcopenia y obesidad sarcopénica fueron del 62,5%, 4,5% y 6,2%, respectivamente. La asociación entre biomarcadores y fenotipos se comprobó mediante modelos de regresión logística multinomial ajustados por variables de confusión. Los modelos mostraron que el incremento de los niveles de glucosa en la sangre (OR = 3,39; IC95%: 1,83-6,27), colesterol total (OR = 2,24; IC95%: 1,35-3,70), LDL-c (OR = 1,01; IC95%: 1,00-1,02), VLDL-c (OR = 1,04; IC95%: 1,02-1,06), no HDL-c (OR = 1,02; IC95%: 1,01-1,03), triglicéridos (OR = 3,66; IC95%: 2,20-6,06) y disminución de HDL-c (OR = 0,97; IC95%: 0,95-0,98) se asociaron significativamente con el fenotipo de obesidad. Las tasas aumentadas de HOMA-IR (OR = 3,94; IC95%: 1,69-9,21), LDL-c (OR = 1,01; IC95%: 1,00-1,02), no-HDL-c (OR = 1,01; IC95%: 1,00-1,02) y PCR-us (OR = 2,42; IC95%: 1,04-5,66) se asociaron de manera independiente con el fenotipo de obesidad sarcopénica. Los resultados demuestran que el aumento de los niveles de glucosa en la sangre, colesterol total, triglicéridos, LDL-c, VLDL-c, no-HDL-c y grados reducidos de HDL-c son indicadores del fenotipo de obesidad y que el incremento de los niveles de PCR-us, HOMA-IR, LDL-c y no-HDL-c son indicadores del fenotipo de obesidad sarcopénica. Estos parámetros se pueden utilizar como marcadores adicionales para el cribado. Resumen lipídicos inflamatorios transversal poblacional 72 2 5 años dual 25 32 mujeres 70kgm2 kgm 7 0kg m2 kg m 7,0kg/m 55kgm2 5kg 5,5kg/m 625 62 62,5% 45 4 4,5 6 6,2% respectivamente confusión OR 3,39 339 3 39 IC95% IC95 IC 1,836,27, 183627 1,83 6,27 , 1 83 27 1,83-6,27) 2,24 224 24 1,353,70, 135370 1,35 3,70 35 70 1,35-3,70) LDLc LDL c 1,01 101 01 1,001,02, 100102 1,00 1,02 00 02 VLDLc VLDL 1,04 104 04 1,021,06, 102106 1,06 06 1,02-1,06) HDLc HDL 102 1,011,03, 101103 1,03 03 1,01-1,03) 3,66 366 66 2,206,06 220606 2,20 6,06 2,20-6,06 0,97 097 0 97 0,950,98 095098 0,95 0,98 95 98 0,95-0,98 HOMAIR HOMA IR 3,94 394 94 1,699,21, 169921 1,69 9,21 69 9 21 1,69-9,21) noHDLc 1,001,02 1,00-1,02 PCRus PCR us 2,42 242 42 1,045,66 104566 5,66 1,04-5,66 LDLc, c, VLDLc, PCRus, us, HOMAIR, IR, cribado 70kgm 55kgm 62,5 4, 6,2 3,3 33 IC9 836 1,836,27 18362 183 1,8 627 8 1,83-6,27 2,2 22 353 1,353,70 13537 135 1,3 370 3,7 1,35-3,70 1,0 10 001 10010 100 021 1,021,06 10210 106 1,02-1,06 011 1,011,03 10110 103 1,01-1,03 3,6 36 206 2,206,0 22060 220 606 6,0 2,20-6,0 0,9 09 950 0,950,9 09509 095 098 0,95-0,9 3,9 699 1,699,21 16992 169 1,6 921 9,2 1,69-9,21 1,001,0 1,00-1,0 2,4 045 1,045,6 10456 566 5,6 1,04-5,6 62, 6, 3, 1,836,2 1836 18 1, 1,83-6,2 2, 1,353,7 1353 13 37 1,35-3,7 1001 1,021,0 1021 1,02-1,0 1,011,0 1011 1,01-1,0 2,206, 2206 60 2,20-6, 0, 0,950, 0950 0,95-0, 1,699,2 1699 16 92 9, 1,69-9,2 1,001, 1,00-1, 1,045, 1045 56 5, 1,04-5, 1,836, 1,83-6, 1,353, 1,35-3, 1,021, 1,02-1, 1,011, 1,01-1, 2,206 2,20-6 0,950 0,95-0 1,699, 1,69-9, 1,001 1,00-1 1,045 1,04-5 1,836 1,83-6 1,353 1,35-3 1,021 1,02-1 1,011 1,01-1 2,20- 0,95- 1,699 1,69-9 1,00- 1,04- 1,83- 1,35- 1,02- 1,01- 1,69-
Abstract: We aimed to verify the prevalence of body composition phenotypes and the association of glycemic, lipidic, and inflammatory biomarkers with such phenotypes. This is a cross-sectional, population-based study, with 720 participants aged 20 to 59 years. Body composition was assessed by dual-energy X-ray absorptiometry. Obesity was defined as body fat percentage ≥ 25% in males and ≥ 32% in females and sarcopenia by appendicular muscle mass index < 7.0kg/m2 in males and < 5.5kg/m2 in females. Sarcopenic obesity (SO) was defined as the presence of both sarcopenia and obesity. The prevalence of obesity, sarcopenia, and SO were 62.5%, 4.5%, and 6.2%, respectively. The association between biomarkers and phenotypes was verified using multinomial logistic regression models adjusted for confounding factors. The models showed that increased glycemia (OR = 3.39; 95%CI: 1.83-6.27), total cholesterol (TC) (OR = 2.24; 95%CI: 1.35-3.70), LDL-c (OR = 1.01; 95%CI: 1.00-1.02), VLDL-c (OR = 1.04; 95%CI: 1.02-1.06), non-HDL-c (OR = 1.02; 95%CI: 1.01-1.03), triglycerides (Tg) (OR = 3.66; 95%CI: 2.20-6.06), and decreased HDL-c (OR = 0.97; 95%CI: 0.95-0.98) were significantly associated with the obesity phenotype. Increased HOMA-IR (OR = 3.94; 95%CI: 1.69-9.21), LDL-c (OR = 1.01; 95%CI: 1.00-1.02), non-HDL-c (OR = 1.01; 95%CI: 1.00-1.02), and hs-CRP (OR = 2.42; 95%CI: 1.04-5.66) were independently associated with SO phenotype. Our findings indicate that increased glycemia, TC, Tg, LDL-c, VLDL-c, non-HDL-c, and decreased HDL-c may be indicators of the obesity phenotype and that increased hs-CRP, HOMA-IR, LDL-c, and non-HDL-c appear to be indicators of the SO phenotype. Those parameters may be used as additional markers for screening. Abstract glycemic lipidic crosssectional, crosssectional cross sectional, sectional cross-sectional populationbased population based study 72 2 5 years dualenergy dual energy Xray X ray absorptiometry 25 32 70kgm2 kgm 7 0kg m2 kg m 7.0kg/m 55kgm2 5kg 5.5kg/m (SO 625 62 62.5% 45 4 4.5% 6 6.2% respectively factors OR 3.39 339 3 39 95%CI 95CI CI 95 1.836.27, 183627 1.83 6.27 , 1 83 27 1.83-6.27) TC (TC 2.24 224 24 1.353.70, 135370 1.35 3.70 35 70 1.35-3.70) LDLc LDL c 1.01 101 01 1.001.02, 100102 1.00 1.02 00 02 1.00-1.02) VLDLc VLDL 1.04 104 04 1.021.06, 102106 1.06 06 1.02-1.06) nonHDLc non HDL 102 1.011.03, 101103 1.03 03 1.01-1.03) Tg (Tg 3.66 366 66 2.206.06, 220606 2.20 6.06 2.20-6.06) HDLc 0.97 097 0 97 0.950.98 095098 0.95 0.98 98 0.95-0.98 HOMAIR HOMA IR 3.94 394 94 1.699.21, 169921 1.69 9.21 69 9 21 1.69-9.21) hsCRP hs CRP 2.42 242 42 1.045.66 104566 5.66 1.04-5.66 LDLc, c, VLDLc, nonHDLc, hsCRP, CRP, HOMAIR, IR, screening 70kgm 55kgm 62.5 4.5 6.2 3.3 33 836 1.836.27 18362 183 1.8 627 8 1.83-6.27 2.2 22 353 1.353.70 13537 135 1.3 370 3.7 1.35-3.70 1.0 10 001 1.001.02 10010 100 1.00-1.02 021 1.021.06 10210 106 1.02-1.06 011 1.011.03 10110 103 1.01-1.03 3.6 36 206 2.206.06 22060 220 606 6.0 2.20-6.06 0.9 09 950 0.950.9 09509 095 098 0.95-0.9 3.9 699 1.699.21 16992 169 1.6 921 9.2 1.69-9.21 2.4 045 1.045.6 10456 566 5.6 1.04-5.6 62. 4. 6. 3. 1.836.2 1836 18 1. 1.83-6.2 2. 1.353.7 1353 13 37 1.35-3.7 1.001.0 1001 1.00-1.0 1.021.0 1021 1.02-1.0 1.011.0 1011 1.01-1.0 2.206.0 2206 60 2.20-6.0 0. 0.950. 0950 0.95-0. 1.699.2 1699 16 92 9. 1.69-9.2 1.045. 1045 56 5. 1.04-5. 1.836. 1.83-6. 1.353. 1.35-3. 1.001. 1.00-1. 1.021. 1.02-1. 1.011. 1.01-1. 2.206. 2.20-6. 0.950 0.95-0 1.699. 1.69-9. 1.045 1.04-5 1.836 1.83-6 1.353 1.35-3 1.001 1.00-1 1.021 1.02-1 1.011 1.01-1 2.206 2.20-6 0.95- 1.699 1.69-9 1.04- 1.83- 1.35- 1.00- 1.02- 1.01- 2.20- 1.69-
Resumo: Objetivou-se verificar a prevalência de fenótipos corporais e suas associações com biomarcadores dos perfis glicídico, lipídico e inflamatório. Trata-se de um estudo transversal, de base populacional, com 720 indivíduos de 20 a 59 anos. A composição corporal foi avaliada por absorciometria com raios X de dupla energia. Obesidade foi definida como percentual de gordura corporal ≥ 25% em homens e ≥ 32% em mulheres e sarcopenia pelo índice de massa muscular apendicular < 7,0kg/m2 em homens e < 5,5kg/m2 em mulheres. A obesidade sarcopênica foi definida como a coexistência de sarcopenia e obesidade. As prevalências de obesidade, sarcopenia e obesidade sarcopênica foram de 62,5%, 4,5% e 6,2%, respectivamente. A associação entre biomarcadores e fenótipos foi verificada por meio de modelos de regressão logística multinomial ajustados por variáveis de confusão. Os modelos mostraram que níveis aumentados de glicemia (OR = 3,39; IC95%: 1,83-6,27), colesterol total (OR = 2,24; IC95%: 1,35-3,70), LDL-c (OR = 1,01; IC95%: 1,00-1,02), VLDL-c (OR = 1,04; IC95%: 1,02-1,06), não HDL-c (OR = 1,02; IC95%: 1,01-1,03), triglicerídeos (OR = 3,66; IC95%: 2,20-6,06) e diminuição do HDL-c (OR = 0,97; IC95%: 0,95-0,98) foram significativamente associados ao fenótipo de obesidade. Índices aumentados de HOMA-IR (OR = 3,94; IC95%: 1,69-9,21), LDL-c (OR = 1,01; IC95%: 1,00-1,02), não HDL-c (OR = 1,01; IC95%: 1,00-1,02) e PCR-us (OR = 2,42; IC95%: 1,04-5,66) foram independentemente associados ao fenótipo de obesidade sarcopênica. Nossos resultados sugerem que níveis aumentados de glicemia, colesterol total, triglicerídeos, LDL-c, VLDL-c, não HDL-c e graus reduzidos de HDL-c são indicadores do fenótipo de obesidade e que o aumento em níveis de PCR-us, HOMA-IR, LDL-c e não HDL-c são indicadores do fenótipo de obesidade sarcopênica. Esses parâmetros podem ser usados como marcadores adicionais para triagem. Resumo Objetivouse Objetivou se glicídico inflamatório Tratase Trata transversal populacional 72 2 5 anos energia 25 32 70kgm2 kgm 7 0kg m2 kg m 7,0kg/m 55kgm2 5kg 5,5kg/m 625 62 62,5% 45 4 4,5 6 6,2% respectivamente confusão OR 3,39 339 3 39 IC95% IC95 IC 1,836,27, 183627 1,83 6,27 , 1 83 27 1,83-6,27) 2,24 224 24 1,353,70, 135370 1,35 3,70 35 70 1,35-3,70) LDLc LDL c 1,01 101 01 1,001,02, 100102 1,00 1,02 00 02 VLDLc VLDL 1,04 104 04 1,021,06, 102106 1,06 06 1,02-1,06) HDLc HDL 102 1,011,03, 101103 1,03 03 1,01-1,03) 3,66 366 66 2,206,06 220606 2,20 6,06 2,20-6,06 0,97 097 0 97 0,950,98 095098 0,95 0,98 95 98 0,95-0,98 HOMAIR HOMA IR 3,94 394 94 1,699,21, 169921 1,69 9,21 69 9 21 1,69-9,21) 1,001,02 1,00-1,02 PCRus PCR us 2,42 242 42 1,045,66 104566 5,66 1,04-5,66 LDLc, c, VLDLc, PCRus, us, HOMAIR, IR, triagem 70kgm 55kgm 62,5 4, 6,2 3,3 33 IC9 836 1,836,27 18362 183 1,8 627 8 1,83-6,27 2,2 22 353 1,353,70 13537 135 1,3 370 3,7 1,35-3,70 1,0 10 001 10010 100 021 1,021,06 10210 106 1,02-1,06 011 1,011,03 10110 103 1,01-1,03 3,6 36 206 2,206,0 22060 220 606 6,0 2,20-6,0 0,9 09 950 0,950,9 09509 095 098 0,95-0,9 3,9 699 1,699,21 16992 169 1,6 921 9,2 1,69-9,21 1,001,0 1,00-1,0 2,4 045 1,045,6 10456 566 5,6 1,04-5,6 62, 6, 3, 1,836,2 1836 18 1, 1,83-6,2 2, 1,353,7 1353 13 37 1,35-3,7 1001 1,021,0 1021 1,02-1,0 1,011,0 1011 1,01-1,0 2,206, 2206 60 2,20-6, 0, 0,950, 0950 0,95-0, 1,699,2 1699 16 92 9, 1,69-9,2 1,001, 1,00-1, 1,045, 1045 56 5, 1,04-5, 1,836, 1,83-6, 1,353, 1,35-3, 1,021, 1,02-1, 1,011, 1,01-1, 2,206 2,20-6 0,950 0,95-0 1,699, 1,69-9, 1,001 1,00-1 1,045 1,04-5 1,836 1,83-6 1,353 1,35-3 1,021 1,02-1 1,011 1,01-1 2,20- 0,95- 1,699 1,69-9 1,00- 1,04- 1,83- 1,35- 1,02- 1,01- 1,69-