To rapidly detect different types of methamphetamine in the field, a portable near infrared spectroscopy (NIR) method was used to model and analyze the collected samples. Transmission spectra of 359 methamphetamine crystal samples (content range of 7.5-99.4%) and 187 methamphetamine tablet samples (content range of 2.43-23.91%) were collected, first-order derivatives and the Savitaki-Golay smoothing method were applied for spectral preprocessing. The drug concentrations in the calibration and validation sample sets were analyzed using high-performance liquid chromatography. The partial least squares quantitative analysis models were built, and the quantitative models for methamphetamine crystals were 2.10, 2.12 and 2.19% for root mean square error of cross-validation (RMSECV), root mean square error of validation (RMSEV) and root mean square error of prediction (RMSEP), respectively; in contrast, RMSECV, RMSEV, and RMSEP of methamphetamine tablets were 0.78, 0.80, and 0.82%, respectively. The results of the internal cross-validation and the methodology review show that the measurements of the modeled results are consistent with the true values, and that the model has good stability and can be used for accurate field measurements. Therefore, real time sample analysis can be performed using NIR technology combined with chemometric models, which helps the police to determine the quality of drugs in a timely manner for case analysis. (NIR 35 content 7.599.4% 75994 7.5 99.4% 7 5 99 4 7.5-99.4% 18 2.4323.91% 2432391 2.43 23.91% 2 43 23 91 2.43-23.91% firstorder first order SavitakiGolay Savitaki Golay preprocessing highperformance high performance chromatography built 210 10 2.10 212 12 2.1 219 19 2.19 crossvalidation cross RMSECV , (RMSECV) RMSEV (RMSEV RMSEP, (RMSEP) respectively contrast 078 0 78 0.78 080 80 0.80 082 82 0.82% values Therefore 3 599 7.599.4 7599 75 7. 994 99.4 9 7.5-99.4 1 4323 2.4323.91 243239 243 2.4 2391 23.91 2.43-23.91 21 2. (RMSECV (RMSEP 07 0.7 08 8 0.8 0.82 59 7.599. 759 99. 7.5-99. 432 2.4323.9 24323 24 239 23.9 2.43-23.9 0. 7.599 7.5-99 2.4323. 2432 23. 2.43-23. 7.59 7.5-9 2.4323 2.43-23 7.5- 2.432 2.43-2 2.43-

Abstract Alternatives have been studied in order to minimize the major environmental impacts arising from the production of cement and steel. Alternatives include adopting composite cements with the incorporation of alternative materials, to reduce the need for cement in the mixtures. Therefore, this study worked on the viability of incorporating steel residues in the mechanical performance of mortar and durability, evaluating the partial and total replacement of Portland Cement (PC) by granulated blast furnace slag (EGAF) and residue from the Desulfurization process of flue gases (FGD). The results found show that the association of these residues in place of cement improved the mechanical performance of the mortars by around 40%. In addition to having a lower modulus of elasticity and lower absorption of water by capillarity, properties that significantly increase the durability of the matrices. The contaminant leaching results did not show any contaminants in harmful amounts. The studies presented demonstrate that the simultaneous use of FGD and EGAF to replace Portland cement were satisfactory, obtaining better mechanical and durability performances than the reference ones, enabling the use of these residues in the production of mortars with low cement content. materials mixtures Therefore PC (PC (EGAF FGD. . (FGD) 40 40% capillarity matrices amounts satisfactory ones content (FGD 4

Resumo Alternativas vêm sendo estudadas com o intuito de minimizar os grandes impactos ambientais provenientes da produção do cimento e aço. Inclusive, adotando cimentos compostos, com incorporação de materiais alternativos, diminuindo a necessidade de cimento nas misturas. Por conseguinte, este trabalho estudou a viabilidade de incorporação de resíduos siderúrgicos no desempenho mecânico e de durabilidade de argamassas, avaliando a substituição parcial e total do Cimento Portland por escória granulada de alto-forno moída (EGAF) e resíduo proveniente do processo de Dessulfurização de Gases de Combustão (FGD). Os resultados encontrados mostram que a associação desses resíduos em substituição ao cimento melhorou cerca de 40% o desempenho mecânico das argamassas. Além de apresentarem um menor módulo de elasticidade e menor absorção de água por capilaridade, propriedades que aumentam significantemente a durabilidade das matrizes. Os resultados de lixiviação de contaminantes não apresentaram nenhum contaminante em quantidade prejudicial. Os estudos apresentados demonstram que a utilização de FGD e EGAF simultâneos para substituir o Cimento Portland foram satisfatórios, obtendo desempenhos mecânicos e de durabilidade superiores aos de referência, viabilizando a utilização desses resíduos na produção de argamassas com baixo teor de cimento. aço Inclusive compostos alternativos misturas conseguinte altoforno alto forno (EGAF FGD. . (FGD) 40 capilaridade matrizes prejudicial satisfatórios referência (FGD 4

BACKGROUND: Maintaining or promoting employment in the presence of disability or reducing the impact of disability on employability should be the adopted focus to decrease the negative impact that disability has on the economy and just as important on the livelihood and well-being of exposed insured individuals. Group risk disability insurance protects an employee's income when illness or injury result in work disability. To achieve this, factors that promote the success of rehabilitation and support for return-to-work of employees following illness and injury need to be understood from an insurance perspective. OBJECTIVES: To explore principles of disability claims management during the rehabilitation and work reintegration stage using a multi-stakeholder approach for the purpose of successful return to work. METHODS: An exploratory qualitative design was used to collect data via semi-structured interviews with 26 purposively selected participants. Interviews were audio-recorded, data were transcribed and analysed thematically. Qualitative research was used to understand the necessary role players in the work reintegration process, factors that hinder and promote work reintegration and best practice principles for Disability Claims Management (DCM). RESULTS: Three themes emerged from the study; (i) role players and their functions with collaboration is integral to disability claims management, (ii) various factors promote and restrict return-to-work planning, and (iii) best practice principles in the DCM pathway that promote return-to-work. These principles include behavioural economics as the central principle, with resource identification and competency, governance, role engagement and education and awareness as supporting principles. CONCLUSION: Collaborative and integrated approaches by role players within a workers' family unit, health system, employer structure and insurance compensation are required for positive return-to-work outcomes. The various role players are responsible for creating policies, structures, intervention strategies, and environments that foster return-to-work. IMPLICATIONS FOR PRACTICE • An integrated approach is required for optimal RTW outcomes as employers' policies restrict work integration. • A collaborative approach by all role players involved in DCM, focusing on positive RTW outcomes is required in the RTW process • Occupational therapists can influence employer incapacity and disability policies in order to keep people employed and productive in the presence of medical conditions with the application of reasonable accommodations where necessary. • Occupational therapists are suitably positioned to outline workplace environment and other supports required to guide and support employees through rehabilitation and RTW and in ensuring that employees who can remain at work while on a partial or fully insured benefit, can engage optimally in aspects of work function.

Resumen La astrocitopatía autoinmune asociada a proteína ácida fibrilar glial (GFAP) fue descripta por primera vez en el año 2016. La manifestación clínica más frecuente es la meningoencefalomielitis asociado a un patrón imagenológico característico que permite la sospecha diagnóstica y su confirmación mediante la determina ción de los anticuerpos en suero y en líquido cefalorra quídeo (LCR). Presentamos el caso de una paciente de 35 años con compromiso del sistema nervioso a nivel central y periférico y un reciente diagnóstico de cáncer de tiroides, que frente al cuadro clínico compatible de meningoencefalomielitis, los hallazgos característicos en resonancia magnética y luego de la exclusión de enfermedades alternativas, finalmente se arribó al diag nóstico por la determinación positiva de anti GFAP en LCR. Realizó tratamiento quirúrgico y con iodo radio activo por su tumor hallado y posteriormente recibió tratamiento con corticoides con mejoría parcial de la signo-sintomatología neurológica. Destacamos que en esta enfermedad las imágenes por resonancia magnética presentan un patrón característico, aunque no patog nomónico, siendo necesario considerar otras causas. Ante una alta sospecha de esta entidad por el cuadro clínico e imagenológico, es conveniente realizar dosaje del anticuerpo en LCR, dada la mayor sensibilidad y especificidad en comparación con su pesquisa en suero, con el fin de arribar al diagnóstico etiológico definitivo como en el caso clínico presentado.

Abstract Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy was described for the first time in 2016. The most common clinical manifestation is menin goencephalomyelitis associated with a characteristic imaging pattern that allows diagnostic suspicion and its confirmation through determination of antibodies in serum and cerebrospinal fluid (CSF). We present a case of a 35-year-old patient with involvement of the central and peripheral nervous system and a recent diagnosis of thyroid cancer, which compared to the compatible clinical picture of meningoencephalomyelitis, characteristic findings on MRI and after the exclusion of alternative pathologies, we finally arrived at the diagnosis by the positive determination of anti-GFAP in CSF. The patient underwent surgical treatment and radioactive iodine for the diagnosed thyroid tumor and she subsequently received treatment with corticosteroids with partial improvement of the neurological symptomatology. We emphasize that in this pathology the MRI images usually depict a characteristic pattern, although not pathogno monic, it is necessary to consider other causes. Before a high suspicion of this entity due to the clinical and imaging picture, it is convenient to measure the anti body in CSF, given the greater sensitivity and specificity compared to its serum screening, in order to arrive to the definitive etiological diagnosis as it was done in the clinical case that is presented.

Resumen: El presente artículo sistematiza, a partir de referencias encontradas en la jurisprudencia de la Corte Suprema de Justicia de los Estados Unidos, los enfrentamientos de pares conceptuales surgidos de discusiones sobre la operatividad de la presunción de la inocencia en el ámbito angloamericano. El estudio demuestra que las conclusiones parciales en cada una de esas confrontaciones, como características definitorias del derecho a la presunción de la inocencia, deben ser obtenidas mediante argumentos consistentes con el fundamento normativo de este derecho. Como resultado, el artículo expone una noción de presunción de la inocencia que abarca cada una de las conclusiones parciales alcanzadas de esa manera.

Abstract: This paper systematizes and compares, based on the reasoning of the U.S. Supreme Court and its decisions, four pairings of concepts that arise from discussions on the operability of the presumption of innocence in the Anglo-American legal system. The article illustrates that the partial conclusions in each of these comparisons must be reached by arguments consistent with the normative foundation of the presumption of innocence principle in order to find the defining characteristics of said principle. Ultimately, the paper sets forth a definition of the presumption of innocence that encompasses each of the partial conclusions thus reached.

Resumen Introducción y objetivos: La demanda de especies nativas con fines ornamentales ha aumentado y su uso representa una estrategia de valoración y conservación de las mismas por parte de la comunidad. Considerando la riqueza de las sierras de Tandilia, el objetivo de este trabajo fue relevar nativas de valor ornamental potencial y proponer sugerencias de uso de las mismas en espacios verdes. M&M: Del relevamiento florístico de un área del sur de Tandilia se elaboró un listado de especies nativas de uso ornamental potencial. Para cada especie se registró: hábito de crecimiento; atributos morfológicos ornamentales; época de floración y, según las características de los ambientales donde prosperan, se le adjudicó al menos una sugerencia de uso. Resultados: Se proponen 47 especies ornamentales, predominando las hierbas perennes (34) y los arbustos (11) y las floraciones primaverales. El follaje fue el atributo ornamental más frecuente. La principal sugerencia de uso fue la categoría macizos y/o canteros a pleno sol en suelos poco profundos, seguida de: macizos y/o canteros a pleno sol en suelos profundos; jardines de rocallas, techos verdes y/o jardines verticales a pleno sol; macizos y/o canteros a media sombra con suelos profundos; macizos y/o canteros a media sombra con suelos poco profundos; macizos, canteros y/o jardines verticales a la sombra; estanques. Conclusiones: Las áreas del sur de Tandilia poseen flora nativa de potencial valor ornamental que podrían emplearse en el diseño de espacios verdes integrando distintas plantaciones, realzando su valor cultural y patrimonial.

Summary Background and aims: The demand for native ornamentáis species has increased and the utilization of novel ornamental crops is a way of promoting their use and care by the community. Considering the high richness of the Tandilia hills, the objective of this study was to survey native plants with potential ornamental value and to propose suggestions for their use in landscaping. M&M: From the floristic survey carried out in a hill area of the south of Tandilia, a list of native species with potential ornamental value was made. For each species, it was recorded: growth habit; ornamental morphological attributes; flowering season and, depending on the environment's characteristics where they thrive, at least one suggestion for landscaping use was made. Results: A total of 47 species were proposed as ornamental, with predominance of perennial herbs (34), shrubs (11) and spring flowering. Foliage was the most frequent ornamental attribute. The main suggestion use category was: full-sun beds in shallow soils, followed in decreasing order by full-sun beds in deep soils; rock gardens, green roofs or full-sun vertical gardens; partial shadow beds in deep soils; partial shadow beds in shallow soils; shadow beds or shadow vertical gardens ponds. Conclusions: The southern hill areas of Tandilia have native flora of potential ornamental value that could be used in landscaping integrating different plantations, enhancing their cultural and patrimonial value.

Abstract The present research work was carried out in Zaruma´s underground workings, a city located in the province of El Oro in the southwest of Ecuador. Zaruma is a city that has been exploited since the 1500's, the urban center sits on a swarm of veins enriched with gold, the antitechnical exploitation has caused the appearance of sinkholes on the surface of the city, with the emergency that occurred in December 2021, partial remediation was carried out corresponding to the filling of the galleries and construction of plugs in order to avoid collapses in the urban area, for the execution of the remediation work required manpower, workers who entered the s underground galleries in which carbon monoxide (CO) was detected, the objective was evaluated the health effects based on the levels of exposure to carbon monoxide. The research methodology is a non-experimental, cross-sectional, descriptive study, with a sample of fifteen workers operating inside the mine, carbon monoxide measurements were taken in the mine workings and symptomatology interviews were applied to the workers taking aspects of age and time of exposure. The results describe that the operators presented symptoms: headaches, nausea, fatigue, weakness; the severity of the symptoms is a function of time and CO concentration. It´s concluded that exposure to CO in high concentrations for a period of time causes intoxication, with headache being the most frequent symptom.

Resumen El presente trabajo de investigación se desarrolló en las galerías subterráneas de Zaruma, ciudad ubicada en la Provincia de El Oro al Sur Oeste del Ecuador. Zaruma es una ciudad que ha sido explotada desde los años 1500, el casco urbano se asienta sobre un enjambre de vetas enriquecidas con oro, la explotación antitécnica ha provocado la aparición de hundimientos en la superficie de la ciudad, con la emergencia sucedida en diciembre del 2021, se realizó la remediación parcial que corresponde al relleno de la galerías y construcción de tapones con la finalidad de evitar colapsos en el casco urbano, para la ejecución de las obras de remediación se requirió de mano de obra, operarios quienes ingresaron a las labores subterráneas en las que se detectaron monóxido de carbono (CO), el objetivo evaluar los efectos en la salud en relación a los niveles de exposición a monóxido de carbono. Se ha aplicado una metodología de investigación no experimental, de corte transversal, descriptivo, con una muestra de quince trabajadores operativos interior mina, se realizó mediciones de monóxido de carbono en las labores mineras y se aplicó entrevistas de sintomatología a los operarios tomando aspectos de edad y tiempo de exposición. Los resultados describen que los operarios presentaron síntomas: cefaleas, náuseas, fatiga, debilidad, la severidad de los síntomas está en función del tiempo y concentración de CO. Se concluye que la exposición a CO en concentraciones altas por un periodo de tiempo causa intoxicación, siendo la cefalea el síntoma que se presenta como el más frecuente.

RESUMEN Objetivo. Estimar los costos incurridos en el control del Aedes aegypti en la región Loreto, en los años 2017 y 2018. Materiales y métodos. Se realizó una evaluación económica retrospectiva parcial de los costos del control del Aedes aegypti de la Dirección Regional de Salud Loreto, durante la ejecución del Plan Regional de Vigilancia y Control de Aedes aegypti. Se revisó documentación como planes, informes de intervenciones y planillas de pago y se realizaron entrevistas al personal profesional implicado en el control vectorial, sobre los costos de las intervenciones de control. Resultados. Se halló, que los costos incurridos en el control del vector del dengue en la Región Loreto en los dos años estudiados ascienden a: 3,807,858 PEN y 4,066,380 PEN durante el 2017 y 2018, respectivamente (1´175,264 USD y 1´1210,232 USD al tipo de cambio del 2017 y 2018). Sin embargo, el efecto de las actividades de control es de corta duración. Conclusiones. El alto costo que implica el control vectorial con los métodos usados actualmente y la corta duración de su efecto lo hace insostenible. Se deben realizar estudios para hallar otros métodos más eficientes para el control del dengue.

ABSTRACT Objective. To estimate the costs incurred in the control of Aedes aegypti in the Loreto region, during the years 2017 and 2018. Materials and methods. We conducted a partial retrospective economic evaluation of the costs of Aedes aegypti control of the Regional Health Directorate Loreto, during the implementation of the Regional Plan for Surveillance and Control of Aedes aegypti. Documentation such as plans, intervention reports and payment slips were reviewed, and interviews were conducted with professional personnel involved in vector control, on the costs of control interventions. Results. We found that the costs incurred in dengue vector control in the Loreto Region in the two years were: PEN 3,807,858 and PEN 4,066,380 during 2017 and 2018, respectively (USD 1,175,264 and USD 1,1210,232 at the 2017 and 2018 exchange rate). However, the effect of control activities is short-lived. Conclusions. The high cost involved in vector control with the methods currently used and the short duration of its effect make it unsustainable. Studies should be conducted in order to find other more efficient methods for dengue control.

RESUMEN En este trabajo, estudiamos el proceso de morfologización que permitió la formación de un prefijo a partir de un adverbio, coincidentes ambos en la forma no. En la metodología, consideramos la teoría de gramaticalización para analizar un corpus de 794 palabras con no- recopiladas a partir de diferentes fuentes que datan desde el siglo XIII al XXI. Los resultados muestran las diferentes etapas del proceso de cambio en el que el adverbio amplió su distribución contextual, lo cual le permitió aparecer frente a sustantivos. En este contexto, el adverbio adquiere características propias de un prefijo de negación con matices de significado específicas según el tipo de base sustantiva a la que se adjunta: negación total para sustantivos deverbales (no inclusión) o negación parcial en el caso de sustantivos concretos (no libro).

ABSTRACT The aim of this paper is to trace the morphologization process that allowed the formation of a prefix from an adverb, both coinciding in the form no. In order to do this, we consider the theory of grammaticalization to analyze a corpus of 794 Spanish words with no-, gathered from different sources from the 13th to the 21st century. The results show the different stages of the change process in which the adverb expanded its contextual distribution, which allowed it to appear before nouns. In this context, the adverb acquires the typical characteristics of a negation prefix, with specific meaning nuances according to the type of noun base it attaches to: total negation for deverbal nouns (no inclusión, ‘non-inclusion’) or partial negation in the case of concrete nouns (no libro, ‘non-book’).

PURPOSE: This study aims to analyse the position of 155 hotel managers in Africa and Asia about implementing sustainability practices (SP) focussing their competitive advantage (CA). Sustainability practices and CA are explained through the technology-organisation-environment (TOE) framework within the hospitality, tourism and travel industries. DESIGN/METHODOLOGY/APPROACH: The Structural Equation Model based on Partial Least Squares (SEM-PLS) methodology was applied to hotels in African countries, including South Africa, as well as Asia. Six variables were analysed in order to study the impact of SP in CA. FINDINGS/RESULTS: Findings imply that technological advancements, organisational commitments and environmental considerations collectively foster robust SP in emerging economies. The adoption of eco-friendly technologies (TS), the integration of sustainable policies (OS) and adherence to environmental regulations (ES) collectively contribute to the sustainability goals of hotels. PRACTICAL IMPLICATIONS: The study reveals that hotels in emerging markets should strategically emphasise the TOE framework to enhance SP and CA. Investing in advanced technologies, implementing effective organisational practices and adhering to environmental standards significantly improve sustainability performance. ORIGINALITY/VALUE: While the TOE model has been extensively studied across various industries, limited research has explored its application in tourism. This study uniquely investigates how SP can enhance CA in the tourism sector through comparative analysis.

Resumo: O Tribunal de Justiça da União Europeia (“TJUE”) solicitou uma alteração do seu Estatuto para fazer face aos desafios decorrentes de uma carga de trabalho crescente. O objetivo é redefinir a competência dos tribunais da UE, a fim de lhes permitir continuar a cumprir, num prazo razoável, a missão que lhes foi atribuída pelos redatores dos Tratados no artigo 19.º, n.º 1, do Tratado UE (“TUE”), nomeadamente, garantir que “a lei é respeitada na interpretação e aplicação dos Tratados”. A reforma prevê especificamente uma transferência parcial de competências interpretativas para o Tribunal Geral (“TG”), combinada com a competência do TJUE para tratar de questões de particular relevância. Além disso, a possibilidade de interpor recurso para o TJUE será limitada se as comissões de recurso das agências da UE já tiverem realizado uma revisão jurídica em primeira instância. Uma série de salvaguardas evitarão uma situação em que a partilha da carga de trabalho entre dois tribunais diferentes possa ter um efeito negativo na uniformidade e na coerência da jurisprudência.

Resumen: El Tribunal de Justicia de la Unión Europea (“TJUE”) ha solicitado una modificación de su Estatuto para hacer frente a los retos derivados de una carga de trabajo cada vez mayor. El objetivo es redefinir la competencia de los órganos jurisdiccionales de la UE con el fin de permitirles seguir cumpliendo, en un plazo razonable, la misión que les han asignado los redactores de los Tratados en el artículo 19, apartado 1, del Tratado de la UE (“TUE”), a saber, garantizar que “en la interpretación y aplicación de los Tratados se respete el Derecho”. La reforma prevé concretamente una transferencia parcial de las competencias interpretativas al Tribunal General (“TG”), combinada con la facultad del TJUE de tratar asuntos de especial relevancia. Además, la posibilidad de interponer un recurso ante el TJUE se limitará si las salas de recurso de las agencias de la UE ya han llevado a cabo una revisión jurídica en primera instancia. Una serie de salvaguardias evitarán una situación en la que el reparto de la carga de trabajo por dos órganos jurisdiccionales distintos pueda tener un efecto negativo en la uniformidad y coherencia de la jurisprudencia.

Résumé: La Cour de justice de l'Union européenne («CJUE») a demandé une modification de son statut afin de faire face aux défis découlant d'une charge de travail croissante. L’objectif est de redéfinir la compétence des juridictions de l’Union européenne afin de leur permettre de continuer à remplir, dans un délai raisonnable, la mission qui leur a été assignée par les rédacteurs des traités, conformément à l’article 19, paragraphe 1, du traité UE («TUE»), à savoir veiller à ce que « le droit soit respecté dans l’interprétation et l’application des traités». La réforme prévoit spécifiquement un transfert partiel des pouvoirs d’interprétation au Tribunal («TG»), ainsi que la compétence de la CJUE de traiter des questions particulièrement pertinentes. En outre, la possibilité de faire appel devant la CJUE sera limitée si les chambres de recours au sein des agences de l'UE ont déjà procédé à un contrôle juridictionnel en première instance. Un certain nombre de garanties permettront d'éviter une situation dans laquelle le partage de la charge de travail entre deux juridictions différentes pourrait avoir un effet négatif sur l'uniformité et la cohérence de la jurisprudence.

Abstract: The Court of Justice of the European Union (“CJEU”) has requested a modification of its Statute to address the challenges arising from an increasing workload. The aim is to redefine the competence of the EU courts in order to enable them to continue to fulfill, within a reasonable time, the mission assigned to them by the drafters of the Treaties in Article 19(1) of the EU Treaty. (“TEU”), namely, ensuring that “the law is respected in the interpretation and application of the Treaties.” The reform specifically provides for a partial transfer of interpretative powers to the General Court (“TG”), combined with the power of the CJEU to deal with matters of particular relevance. Furthermore, the possibility of bringing an appeal to the CJEU will be limited if the appeal boards of the EU agencies have already carried out a legal review in the first instance. A number of safeguards will avoid a situation where the sharing of the workload between two different courts could have a negative effect on the uniformity and consistency of case law.

Abstract: Recycled concrete aggregate can be utilized in structural concrete in order to reduce the use of natural resources and the harmful impacts of waste concrete on the environment. This present research aimed to assess the effectiveness of using recycled aggregate concrete with the partial replacement of cement by silica fume (SF) to analyze the microstructural and mechanical properties of recycled aggregate concrete (RAC). In this study, recycled stone was used as coarse aggregate. The main variables of the study included the dosage of silica fume that was employed as a partial replacement of ordinary Portland cement (OPC) with four different percentages: 4%, 8%, 12%, and 16% by weight. Five different mixes were prepared, with four mixes created by varying amounts of silica fume, which were designated as RSACSF4, RSACSF8, RSACSF12, and RSACSF16. The other mix was created as a reference mix without silica fume and designated RSACSF0. Slump test was conducted to investigate the workability of concrete mixes. From the test result, a decreasing trend was found after adding more percentage of SF. Compressive and splitting tensile tests were conducted to analyze the mechanical properties of RSAC at 7 and 28 days. The results showed that the addition of SF improved the performance of RSAC at early and later curing ages, and a 12% addition of SF showed the best result. Scanning electron microscopy and X-ray diffraction analysis were performed to explore SF's microstructural performance and effect on RSAC. The results showed that silica fume showed a positive pozzolanic impact, and when combined with calcium hydroxide, it underwent a secondary hydration reaction that boosted the generation of calcium silicate hydrate and improved the parameters of the interface transition zone. X-ray diffraction analysis showed that silica fume and silica fume have similar pattern intensities. Finally, 12% SF is recommended as a partial replacement for cement in RSAC

RESUMEN Objetivo. Estimar los costos incurridos en el control del Aedes aegypti en la región Loreto, en los años 2017 y 2018. Materiales y métodos. Se realizó una evaluación económica retrospectiva parcial de los costos del control del Aedes aegypti de la Dirección Regional de Salud Loreto, durante la ejecución del Plan Regional de Vigilancia y Control de Aedes aegypti. Se revisó documentación como planes, informes de intervenciones y planillas de pago y se realizaron entrevistas al personal profesional implicado en el control vectorial, sobre los costos de las intervenciones de control. Resultados. Se halló, que los costos incurridos en el control del vector del dengue en la Región Loreto en los dos años estudiados ascienden a: 3,807,858 PEN y 4,066,380 PEN durante el 2017 y 2018, respectivamente (1´175,264 USD y 1´1210,232 USD al tipo de cambio del 2017 y 2018). Sin embargo, el efecto de las actividades de control es de corta duración. Conclusiones. El alto costo que implica el control vectorial con los métodos usados actualmente y la corta duración de su efecto lo hace insostenible. Se deben realizar estudios para hallar otros métodos más eficientes para el control del dengue.

ABSTRACT Objective. To estimate the costs incurred in the control of Aedes aegypti in the Loreto region, during the years 2017 and 2018. Materials and methods. We conducted a partial retrospective economic evaluation of the costs of Aedes aegypti control of the Regional Health Directorate Loreto, during the implementation of the Regional Plan for Surveillance and Control of Aedes aegypti. Documentation such as plans, intervention reports and payment slips were reviewed, and interviews were conducted with professional personnel involved in vector control, on the costs of control interventions. Results. We found that the costs incurred in dengue vector control in the Loreto Region in the two years were: PEN 3,807,858 and PEN 4,066,380 during 2017 and 2018, respectively (USD 1,175,264 and USD 1,1210,232 at the 2017 and 2018 exchange rate). However, the effect of control activities is short-lived. Conclusions. The high cost involved in vector control with the methods currently used and the short duration of its effect make it unsustainable. Studies should be conducted in order to find other more efficient methods for dengue control.

RESUMO Este relato descreve um cão com anemia e TIM associada ao fenobarbital, tratado com prednisolona, e boa resposta após associação com três transplantes de 2,5x106 células-tronco mesenquimais alogênicas. Após o primeiro transplante, o número de plaquetas melhorou, mas começou a regredir após três semanas. Contudo, pode-se reduzir a dose de corticosteroide. Após a segunda e terceira administrações, observaram-se novos aumentos. A contagem de plaquetas variou de 102.000 a 365.000 até o final do acompanhamento, sem necessidade de aumentar as doses de prednisolona. Embora a terapia com fenobarbital seja associada à trombocitopenia, não foi possível alterar a terapia anticonvulsivante. A resposta à corticoterapia foi parcial. A terapia celular foi associada à melhora na contagem plaquetária, sem efeitos adversos relacionados e, dessa forma, pode ser considerada segura. Efeitos na contagem de plaquetas foram transitórios, mas, até o final do acompanhamento, não se observou trombocitopenia severa. Com base na observação de que o número de plaquetas caiu poucas semanas após a terapia celular, mais aplicações seriam benéficas, no intuito de manter a contagem de plaquetas mais alta. prednisolona 25x106 x 2 5x106 2,5x10 célulastronco células tronco alogênicas transplante melhorou Contudo podese corticosteroide administrações observaramse observaram aumentos 102000 102 000 102.00 365000 365 365.00 acompanhamento anticonvulsivante parcial plaquetária forma segura transitórios severa benéficas alta 25x10 5x10 2,5x1 10200 10 00 102.0 36500 36 365.0 25x1 5x1 2,5x 1020 1 0 102. 3650 3 365. 25x 5x

ABSTRACT This report describes a dog with anemia and ITP, associated with phenobarbital, treated with prednisolone with a good response after association with three intravenous transplantations of 2.5x106 allogenic Mesenchymal Stem-Cells. After the first transplantation, the number of platelets had an improvement, but started to decrease after three weeks. However, the dose of corticosteroid could be reduced. After the second and third administrations, new increases were observed. The platelet count varied from 102,000 to 365,000 until the end of follow-up and without increase of prednisolone doses. Although phenobarbital therapy has been associated with thrombocytopenia, it was not possible to change the anti-convulsant therapy. The response to corticosteroid-based therapy was partial. Cell therapy was followed by an improvement in platelet count with no observed side effects and therefore could be considered safe. Effects on platelet count were transitory, but until the end of follow-up, no severe thrombocytopenia was observed. Based on the observation that platelet numbers dropped a few weeks after cell therapy, more applications would be beneficial in order to maintain higher platelet counts. ITP 25x106 x 2 5x106 2.5x10 StemCells. StemCells Stem Cells. Cells Stem-Cells transplantation However reduced administrations 102000 102 000 102,00 365000 365 365,00 followup follow up doses anticonvulsant anti convulsant corticosteroidbased based partial safe transitory followup, up, counts 25x10 5x10 2.5x1 10200 10 00 102,0 36500 36 365,0 25x1 5x1 2.5x 1020 1 0 102, 3650 3 365, 25x 5x

Resumo Foram abordados neste estudo micro concretos autoadensáveis ecoeficientes com substituição parcial do cimento Portland por resíduo de rochas ornamentais (do inglês ornamental stone waste - OSW) e substituição dos agregados convencionais por resíduo de poliestireno expandido. A dosagem foi feita utilizando metodologia de empacotamento de partículas, e as frações de substituição seguiram um projeto experimental estatístico composto de segunda ordem. Foram avaliados e discutidos os parâmetros reológicos, físicos, mecânicos e de ecoeficiência das misturas. Como esperado, a incorporação dos resíduos diminuiu a resistência mecânica, e as misturas com elevadas incorporações de agregados leves apresentaram tendência a segregação. Entretanto, a adição do resíduo OSW demonstrou aumentar a trabalhabilidade e diminuir a viscosidade, contribuindo para controlar a segregação devido à redução no consumo de água necessário sem prejudicar a fluidez da mistura. Ao mesmo tempo, o agregado leve diminuiu tanto a densidade das misturas quanto a viscosidade. A interação do resíduo com o agregado leve se mostrou promissora na obtenção de microconcretos leves mais ecoeficientes. expandido partículas ordem reológicos físicos esperado mecânica Entretanto viscosidade mistura tempo

Abstract Eco-efficient self-compacting micro concretes with partial replacement of Portland cement by ornamental stone waste (OSW) and replacement of conventional aggregates by expanded polystyrene waste were addressed in this study. A base mixture was obtained using a particle packing method, and replacement fractions followed a second-order composite experimental design. The mixtures’ rheological, physical, mechanical and eco-efficiency parameters were evaluated and discussed. As expected, the incorporation of residues reduced the mechanical strength, and mixtures with high incorporation of lightweight aggregates tended to segregate. However, OSW has been shown to increase workability and decrease viscosity, contributing to control segregation due to the reduced amount of water required without impairing the fluidity of the mix. At the same time, the lightweight aggregate decreased both the density of the mixtures and the viscosity. The interaction of the residue with the lightweight aggregate proved promising in obtaining more eco-efficient lightweight microconcretes. Ecoefficient Eco efficient selfcompacting self compacting (OSW study method secondorder second order design rheological physical ecoefficiency eco efficiency discussed expected strength segregate However viscosity mix time ecoefficient microconcretes