Iron is an important ion that regulates many metabolic functions in the human body, and its deficiency or overload can cause serious health problems. In view of this, the development of tools that can quantify iron in aqueous media is quite valuable. A new material based on a metal-organic framework (MOF) and a calixarene derivative (CALIX), here named CALIX@UiO-66-NH2, was successfully prepared and used as a luminescent sensor for iron ions in a water matrix containing various metal ions. The post-synthetic modification was demonstrated to be efficient on the MOF (UiO-66-NH2) modification, leading to a hybrid platform. The effect of the combination of both components (MOF and CALIX) led to a platform more sensitive to iron detection than the independent compounds. The CALIX@UiO-66-NH2 sensor shows a linear response toward Fe3+ ions with satisfactory linearity (R2 = 0.994) within the concentration range of 6.74 × 10−6−1.72 × 10−5 mol L−1. The limit of detection was determined to be as low as 1.6 mg L−1. The data demonstrate that CALIX@UiO-66-NH2 is an excellent probe for detecting Fe3+, as confirmed by almost complete fluorescence suppression. body problems this valuable metalorganic organic CALIX, CALIX , (CALIX) CALIX@UiO66NH2, CALIXUiO66NH2 CALIXUiONH CALIX@UiO 66 NH2, UiO NH2 NH postsynthetic post synthetic UiO66NH2 UiONH (UiO-66-NH2 compounds CALIX@UiO66NH2 CALIX@UiO-66-NH Fe3 Fe R2 R (R 0.994 0994 0 994 674 6 74 6.7 106172 10 1 72 10−6−1.7 105 5 10− L1 L L−1 16 1. suppression (CALIX CALIXUiO CALIXUiO66NH UiO66NH (UiO-66-NH CALIX@UiO66NH 0.99 099 99 67 7 6. 10617 10−6−1. L− 0.9 09 9 1061 10−6−1 0. 106 10−6− 10−6

Abstract: Role overload in the family can be understood as a feeling of inability to complete duties that are the individual's responsibility, and this hardship occurs due to the accumulation of tasks in the family, which can cause discomfort. The aim of this study was to obtain valid evidence of Family Role Overload in Brazilian samples. Six hundred and forty Brazilian workers of both genders took part in the study. Confirmatory factor analyses showed that the Brazilian version remained single-factor and had six items. The multi-group analyses showed configural, metric, and scalar invariance between the groups divided in terms of gender and the existence or absence of children. The scale showed positive correlations with perceived family demands and family-work conflict and a negative correlation with perceived social support in the family. It was therefore concluded that the instrument had psychometric properties that recommend its use in future research.

Resumo: A sobrecarga de papeis na família pode ser compreendida como sentimento de incapacidade em concluir obrigações que são de responsabilidade do indivíduo, e essa dificuldade acontece devido ao acúmulo de tarefas na família, que podem trazer desconforto. O presente trabalho teve por objetivo obter evidências de validade da Sobrecarga de Papéis na Família em amostras brasileiras. Participaram do estudo 640 trabalhadores brasileiros, de ambos os gêneros. As análises fatoriais confirmatórias evidenciaram que a versão brasileira se manteve unifatorial e com seis itens. As análises multigrupo atestaram a invariância configural, métrica e escalar entre os grupos divididos em termos de gênero e sobre a presença ou ausência de filhos. A escala apresentou correlações positivas com demandas percebidas da família e conflito família-trabalho e correlação negativa com suporte social percebido na família. Concluiu-se, assim, que o instrumento apresentou propriedades psicométricas que recomendam seu uso em investigações futuras.

Resumen: La sobrecarga de rol en la familia puede ser entendida como un sentimiento de incapacidad para completar las obligaciones que son responsabilidad del individuo, y esta dificultad ocurre debido a la acumulación de tareas en la familia, lo que puede causar malestar. El objetivo de este estudio fue obtener evidencias de la validez de la Escala de Sobrecarga del Rol Familiar en muestras brasileñas. Participaron en el estudio 640 trabajadores brasileños de ambos sexos. Los análisis factoriales confirmatorios mostraron que la versión brasileña se mantuvo monofactorial y con seis ítems. Los análisis multigrupo mostraron invariancia configuracional, métrica y escalar entre los grupos divididos en función del género y de la presencia o ausencia de hijos. La escala mostró correlaciones positivas con las demandas familiares percibidas y el conflicto familia-trabajo y una correlación negativa con el apoyo social percibido en la familia. Por lo tanto, se concluyó que el instrumento posee propiedades psicométricas que recomiendan su uso en futuras investigaciones.

Abstract The mental health for workers in healthcare was affected by the overload derived from care for COVID-19 patients. It is recognized that there was no knowledge about the disease or labor systems prepared to deal with the pandemic. Mental health problems among of a group of eight nursing workers (6 women and 2 men) employed at a state health institution was addressed through a mutual help group created as an emotional support network. The information co-created by the group across 10 sessions was analyzed through narratives using a relativistic approach, with the thematic axes of emotional discomfort in the face of uncertainties and aggressions; need to be and moral dilemmas; courage to overcome institutional disorganization; emotional overload and the recovery of strategies and resources. The implications of the process narrated by the group resulted in an effective strategy for improving the mental health of the participants and the need to have virtual services to cope with needs or circumstances such as those triggered by a pandemic as well as the strength of the group process are discussed.

Resumen La salud mental del personal sanitario quedó afectada ante la sobrecarga derivada de la atención a pacientes por COVID-19. Se entiende que no había conocimientos sobre la enfermedad ni sistemas laborales preparados para atender la pandemia. La problemática de salud mental de un grupo de 8 profesionales de enfermería (6 mujeres y 2 hombres), laborando en una institución de salud estatal, fue atendida a través de un grupo de ayuda mutua creado como dispositivo de contención emocional. Se analiza la información co-creada por el proceso grupal de 10 sesiones a través de las narrativas desde un enfoque relativista, con los ejes temáticos del malestar emocional ante las incertidumbres y las agresiones; el deber ser y las disyuntivas morales; el coraje impulsor ante la desorganización institucional, la sobrecarga emocional y la recuperación de estrategias y recursos. Se discuten las implicaciones del proceso narrado por el grupo constituido como una estrategia efectiva para la mejora en la salud mental de los participantes y la necesidad de tener dispositivos virtuales ante necesidades o circunstancias como las detonadas por una pandemia, así como la fortaleza del proceso grupal.

Abstract Objective To assess the outcome of patients with cancer-related sepsis requiring continuous renal replacement therapy (CRRT) in a single-center pediatric intensive care unit (PICU). Method Children with sepsis who necessitate CRRT from January 2017 to December 2021 were enrolled. The patients with leukemia/lymphoma or solid tumors were defined as underlying cancer. Multivariate logistic regression analysis was performed to identify the death risk factors in patients with cancer-related sepsis. Results A total of 146 patients were qualified for inclusion. Forty-six (31.5%) patients with cancer-related sepsis and 100 (68.5%) non-cancer-related sepsis. The overall PICU mortality was 28.1% (41/146), and mortality was significantly higher in cancer-related sepsis patients compared with non-cancer patients (41.3% vs. 22.0%, p = 0.016). Need mechanical ventilation, p-SOFA, acute liver failure, higher fluid overload at CRRT initiation, hypoalbuminemia, and high inotropic support were associated with PICU mortality in cancer-related sepsis patients. Moreover, levels of IL-6, total bilirubin, creatinine, blood urea nitrogen, and international normalized ratio were significantly higher in non-survivors than survivors. In multivariate logistic regression analysis, pediatric sequential organ failure assessment (p-SOFA) score (OR:1.805 [95%CI: 1.047-3.113]) and serum albumin level (OR: 0.758 [95%CI: 0.581 -0.988]) were death risk factors in cancer-related sepsis receiving CRRT, and the AUC of combined index of p-SOFA and albumin was 0.852 (95% CI: 0.730-0.974). Conclusion The overall PICU mortality is high in cancer-related sepsis necessitating CRRT. Higher p-SOFA and lower albumin were independent risk factors for PICU mortality. cancerrelated cancer related (CRRT singlecenter single center PICU. . (PICU) 201 202 enrolled leukemialymphoma leukemia lymphoma 14 inclusion Fortysix Forty six 31.5% 315 31 5 (31.5% 10 68.5% 685 68 (68.5% noncancerrelated non 281 28 1 28.1 41/146, 41146 41/146 , 41 (41/146) noncancer 41.3% 413 3 (41.3 vs 220 22 0 22.0% 0.016. 0016 0.016 016 0.016) ventilation pSOFA, pSOFA SOFA, SOFA initiation hypoalbuminemia Moreover IL6, IL6 IL 6, 6 IL-6 bilirubin creatinine nitrogen nonsurvivors survivors (p-SOFA OR1.805 OR1805 OR 1.805 805 (OR:1.80 95%CI 95CI CI 95 [95%CI 1.0473.113 10473113 1.047 3.113 047 113 1.047-3.113] (OR 0758 758 0.75 0581 581 0.58 0.988 0988 988 -0.988] 0852 852 0.85 95% (95 0.7300.974. 07300974 0.730 0.974 730 974 0.730-0.974) (PICU 20 31.5 (31.5 68.5 (68.5 2 28. 4114 41/14 4 (41/146 41.3 (41. 22.0 001 0.01 01 IL- OR1 OR1.80 OR180 1805 1.80 80 (OR:1.8 9 0473 1.0473.11 1047311 1047 1.04 3113 3.11 04 11 1.047-3.113 075 75 0.7 058 58 0.5 0.98 098 98 -0.988 085 85 0.8 (9 7300 0.7300.974 0730097 0730 0.73 0974 0.97 73 97 0.730-0.974 31. (31. 68. (68. 411 41/1 (41/14 41. (41 22. 00 0.0 OR1.8 OR18 180 1.8 8 (OR:1. 1.0473.1 104731 104 1.0 311 3.1 1.047-3.11 07 7 0. 05 0.9 09 -0.98 08 ( 0.7300.97 073009 073 097 0.730-0.97 (31 (68 41/ (41/1 (4 OR1. 18 1. (OR:1 1.0473. 10473 3. 1.047-3.1 -0.9 0.7300.9 07300 0.730-0.9 (3 (6 (41/ 1.0473 1.047-3. -0. 0.7300. 0.730-0. 1.047-3 -0 0.7300 0.730-0 1.047- - 0.730-

Abstract Background: Safety is a crucial aspect of healthcare provision. Incidents or adverse events in healthcare can often be prevented and must be reported when they occur. Objective: To assess nurses’ opinions about the process of reporting adverse events in their institution, the barriers to the process, and the strategies to promote it. Methodology: A simple descriptive study was conducted with 62 nurses working at the operating room of a central hospital in the center of Portugal. A questionnaire was administered in February 2022. Results: The main barriers identified were the lack of a reporting culture, work overload, lack of feedback, forgetfulness, and insufficient knowledge about the system and what to report. The strategies identified to promote the reporting process were training, feedback, and debriefings. Conclusion: Institutions should create favorable environments for professionals to report incidents.

Resumo Enquadramento: A segurança na prestação de cuidados de saúde é um fator que assume grande importância. Sendo que a maioria dos incidentes ou eventos adversos associados à prestação de cuidados podem ser evitados e quando ocorrem devem ser notificados. Objetivo: Avaliar a opinião dos enfermeiros relativamente ao processo de notificação de eventos adversos existente na instituição; conhecer na opinião dos enfermeiros as barreiras à notificação e estratégias a adotar para promover a mesma. Metodologia: Estudo descritivo simples realizado com a participação de 62 Enfermeiros do Bloco Operatório Central de um Centro Hospitalar da zona centro de Portugal, que preencheram um questionário em fevereiro de 2022. Resultados: As principais barreiras identificadas foram: a falta de cultura de reporte, sobrecarga de trabalho, ausência de feedback, esquecimento, conhecimento insuficiente sobre o sistema informático e o que reportar. As estratégias identificadas pelos profissionais como promotoras do processo de notificação foram a formação, o feedback e os debriefings. Conclusão: As instituições devem criar condições favoráveis a prática de notificação.

Resumen Marco contextual: La seguridad en la prestación de cuidados sanitarios es un factor de gran importancia. La mayoría de los incidentes o acontecimientos adversos asociados a la prestación de cuidados pueden evitarse y, cuando ocurren, deben notificarse. Objetivo: Evaluar la opinión del personal de enfermería sobre el proceso de notificación de acontecimientos adversos en la institución; conocer, en opinión del personal de enfermería, los obstáculos para la notificación y las estrategias que deben adoptarse para promoverla. Metodología: Estudio descriptivo simple realizado con la participación de 62 enfermeros del Quirófano Central de un Centro Hospitalario del centro de Portugal, que cumplimentaron un cuestionario en febrero de 2022. Resultados: Los principales obstáculos identificados fueron: falta de cultura de notificación, sobrecarga de trabajo, falta de feedback, olvido, falta de conocimientos sobre el sistema informático y sobre qué notificar. Las estrategias identificadas por los profesionales como facilitadoras del proceso de notificación fueron la formación, el feedback y los debriefings. Conclusión: Las instituciones deben crear condiciones favorables para la práctica de la notificación.

Abstract A basic iron profile often provides a useful approach to ferropenic or iron-sequestered inflammatory conditions, but sometimes also to the primary suspicion of iron overloading pathologies, which may or may not, at last, harbor a real iron overload. Therefore, a thoughtful interpretation of the results is mandatory to avoid misdiagnosis. The serum iron concentration reflects the quantity of iron moving at one moment from ferroportin- to transferrin receptor-1-expressing cells, while the transferrin concentration reflects the organism avidity for iron. But serum ferritin concentration may reflect iron deposits as well as inflammatory conditions, hence being difficult the interpretation of its normal or high values. In this paper I distinguish, among abnormal iron profiles, those with evident iron overload from those with hiperferritinemia without (clear) evidence of iron overload, although there is a frequent overlap between these two conditions. Secondary reactive hiperferritinemia is, by far, much more common than hiperferritinemia related to iron overload, as it is also frequent to deal with patients with more than one cause for their hiperferritinemia. "Reactive hiperferritinemia of unknown origin" should be the temporary diagnosis for patients with (yet) no evident etiology for their hiperferritinemia. Some patients have clearly absence or presence of iron overload, but in many cases this condition is doubtful, incomplete or intermittent. Hence, it is difficult in some cases to decide the need for chelation therapy. Iron overload, if present, may be secondary (basically to ineffective erythropoiesis) or primary. Primary iron overload may be, in turn, classified as hemochromatosic (HFE or non HFE) or non hemochromatosic. Although very rare, the non hemochromatosic primary iron overloads have confounding iron profiles, but with an easy approach if suspected. One of them, the ferroportin disease, just the opposite of hemochromatosis, deserves some attention, for it is not very infrequent. Finally, the diagnosis of hemochromatosis must be supported by an unequivocal typical iron profile and by biallelic severe HFE mutations or, rarer, mutations in non-HFE genes. The last but not the least, mild HFE mutations, as H63D, either mono o biallelic, do not justify by themselves any typical iron overload. In presence of such a genetic diagnosis, other cause(s) of iron overload must be looked for: non-HFE hemochromatosis if the iron profile is typically hemochromatosic, non-hemochromatosic iron overload (primary o secondary) if not. The risk of considering a mild HFE mutation (even in the case of HFE C282Y/H63D double heterozygous) as responsible for an iron overload or a hiperferritinemia is to overlook other causes for these conditions that may deserve particular and, eventually, more imperative attention and treatment.

Resumen Con frecuencia un perfil básico de hierro orienta hacia condiciones ferropénicas o de secuestro inflamatorio del hierro, pero a veces también hacia la sospecha de patologías con sobrecarga de hierro, que pueden o no terminar confirmándose. Por lo tanto, es necesaria una interpretación precisa de los resultados para evitar errores diagnósticos. La ferremia refleja la cantidad de hierro en tránsito en un momento determinado desde células que expresan la ferroportina hacia las que expresan el receptor de transferrina-1, mientras que la transferrinemia refleja la avidez del organismo por el hierro. Pero la ferritinemia puede ser reflejo tanto de los depósitos de hierro como de condiciones inflamatorias, con la consiguiente dificultad para interpretar sus resultados normales o elevados. En este articulo diferencio, entre los perfiles de hierro sugestivos de sobrecarga, los que cursan con una sobrecarga de hierro evidente de los que presentan sólo una hiperferritinemia sin evidencia (franca) de sobrecarga de hierro, aunque la superposición entre ambas situaciones es frecuente. La hiperferritinemia secundaria reactiva es, por mucho, más frecuente que la vinculada a sobrecarga de hierro, así como es común encontrar pacientes con más de una causa de hiperferritinemia. "Hiperferritinemia reactiva de origen desconocido" puede ser un rótulo diagnóstico provisorio para aquellos pacientes sin una causa (hasta el momento) evidente de su hiperferritinemia. Algunos pacientes tienen claramente presencia o ausencia de sobrecarga de hierro, pero en muchos casos la situación es dudosa, incompleta o intermitente. En consecuencia, es a veces difícil decidir sobre la indicación o no de una terapia quelante. La sobrecarga de hierro, de estar presente, puede ser secundaria (básicamente a patologías con eritropoyesis inefectiva) o primaria. Ésta, a su vez, puede ser clasificada como hemocromatósica (HFE o no HFE) o no hemocromatósica. Aunque muy raras, las sobrecargas de hierro primarias no hemocromatósicas tienen perfiles de hierro confundentes, pero fácilmente interpretables si se las sospecha. Una de ellas, la enfermedad por ferroportina, en las antípodas de las hemocromatosis, merece ser tenida en cuenta, ya que no es muy infrecuente. Finalmente, el diagnóstico de una hemocromatosis debe estar apoyado en un perfil de hierro inequívoco y confirmado por mutaciones HFE severas bialélicas o, más raramente, por mutaciones en genes no HFE. Por el contrario, mutaciones HFE leves, como la H63D, tanto en condición mono como bialélica, no justifican por sí solas una sobrecarga de hierro típica. Frente a esta situación debemos investigar otra(s) causa(s) de sobrecarga de hierro: hemocromatosis no HFE si el perfil de hierro es típicamente hemocromatósico, o sobrecargas de hierro no hemocromatósicas (primarias o secundarias) en caso contrario. El riesgo de considerar una mutación HFE leve (aún en la condición doble heterocigota HFE C282Y/H63D) como responsable única de la sobrecarga de hierro o de una hiperferritinemia, es dejar de lado otras condiciones que pueden merecer atención y tratamiento quizás más prioritarios.

Resumen Introducción. La hemocromatosis hereditaria es un trastorno metabólico hereditario común del metabolismo del hierro con penetrancia variable. La trombosis de la vena porta tiene varias causas bien conocidas que incluyen cirrosis, neoplasia mieloproliferativa, afecciones inflamatorias del abdomen, neoplasia maligna intraabdominal, cirugía intraabdominal y trombofilia. Se desconoce si la hemocromatosis hereditaria está asociada con la trombosis de la vena porta. Material y metodología. Se realizó un análisis retrospectivo de la base de datos de la Muestra Nacional de Pacientes Hospitalizados de 2016 a 2020 utilizando los códigos de la Clasificación Internacional de Enfermedades-10 para identificar hospitalizaciones con trombosis de la vena porta. Utilizamos un análisis de regresión multivariado para calcular el odds ratio ajustado después de controlar por edad, sexo, tipo de seguro, índice de comorbilidad de Charlson, cirrosis, neoplasia mieloproliferativa, afecciones inflamatorias del abdomen, neoplasia maligna intraabdominal, cirugía intraabdominal, antecedentes de trombosis pasada, trombofilia, enfermedad renal terminal, obesidad, tabaquismo e hiperlipidemia. Resultados . Hubo 25.805 hospitalizaciones con diagnóstico primario de trombosis de la vena porta. La regresión logística multivariada mostró que la hemocromatosis hereditaria se asoció de forma independiente con la trombosis de la vena porta (odds ratio = 4.7, IC del 95 % = 1.15 a 19.35, valor de p = 0,03) cuando se controlaron cirrosis, neoplasia mieloproliferativa, afecciones inflamatorias del abdomen, neoplasia maligna intraabdominal, antecedentes de trombosis, antecedentes de cirugía abdominal, antecedentes de trombofilia y enfermedad renal terminal, entre otros factores.

Abstract Introduction. Hereditary hemochromatosis is a common inherited metabolic disorder of iron metabolism with variable penetrance. Portal vein thrombosis has several well-known causes including cirrhosis, myeloproliferative neoplasm, inflammatory conditions of the abdomen, intra-abdominal malignancy, intra-abdominal surgery, and thrombophilia. It is unknown whether hereditary hemochromatosis is associated with portal vein thrombosis. Material and methodology. A retrospective analysis of the National Inpatient Sample database from 2016 to 2020 was conducted using International Classification of Diseases-10 codes to identify hospitalizations with portal vein thrombosis. We used multivariate regression analysis to calculate the adjusted odds ratio after controlling for age, gender, insurance type, Charlson Comorbidity Index, cirrhosis, myeloproliferative neoplasm, inflammatory conditions of the abdomen, intra-abdominal malignancy, intra-abdominal surgery, history of past thrombosis, thrombophilia, end-stage renal disease, obesity, smoking, and hyperlipidemia. Results. There were 25805 hospitalizations with primary diagnosis of portal vein thrombosis. Multivariate logistic regression showed that hereditary hemochromatosis was independently associated with portal vein thrombosis (Odds ratio= 4.7, 95% CI=1.15 to 19.35, p-value=0.03) when cirrhosis, myeloproliferative neoplasm, inflammatory conditions of the abdomen, intra-abdominal malignancy, history of thrombosis, history of abdominal surgery, history of thrombophilia, and end-stage renal disease among other factors were controlled.

Abstract Introduction: Primary Health Care plays a crucial role in the support of women experiencing domestic violence, serving as the entry point for users. Objective: To understand the perceptions of healthcare professionals regarding the care provided to women experiencing domestic violence. Methodology: A descriptive-exploratory qualitative study conducted in August 2023 with 20 healthcare professionals in Campo Grande, Mato Grosso do Sul. Results: The professionals revealed a lack of knowledge about how to handle and the existing flow in the municipality, difficulties in attending to women who are victims of domestic violence, and strategies for managing care for these women. The underreporting of domestic violence is attributed to professionals' inexperience and lack of training, as well as obstacles such as inadequate physical infrastructure and work overload. Final Considerations: It is suggested to reflect on creating a flowchart in Primary Health Care, developing guiding protocols, and the continuous development of tools and training. Further research is essential.

Resumo Introdução: A Atenção Primária em Saúde desempenha um papel crucial no atendimento de mulheres em situação de violência doméstica, sendo a porta de entrada para as usuárias. Objetivo: compreender a percepção de profissionais da saúde sobre o atendimento às mulheres em situação de violência doméstica. Metodologia: Estudo qualitativo descritivo-exploratório, realizado em agosto de 2023 com 20 profissionais de saúde em Campo Grande, Mato Grosso do Sul. Resultados: Os profissionais revelaram desconhecimento sobre como lidar e de fluxo existente no município, dificuldades no atendimento das mulheres vítimas de violência doméstica e estratégias para conduzir o atendimento às mulheres vítimas de violência doméstica. A subnotificação da violência doméstica é atribuída à inexperiência e falta de capacitação dos profissionais, além de obstáculos como estrutura física inadequada e sobrecarga de trabalho. Considerações finais: Sugere-se a reflexão sobre a criação de um fluxograma na Atenção Primária em Saúde, protocolos orientadores, o desenvolvimento contínuo de ferramentas e capacitações e mais pesquisas são essenciais.

Abstract Introduction: Work activities incorporate physical, social, emotional, and technical elements. In a scenario of constant change, it is imperative to understand the current scientific knowledge on the structure and work conditions of nurses in primary health care (PHC). Objective: To identify, in the scientific literature, the aspects related to the work environment that influence the performance of nurses in PHC. Materials and Methods: This is an integrative literature review conducted in August 2023 in the Lilacs, Cinahl, Web of Science, Medline, Scopus, and Embase databases, following the Prisma 2020 Statement guidelines. The inclusion criteria were complete electronic articles, published in Portuguese, English, or Spanish between 2019 and 2023. This review used the ROBIS instrument to assess the risk of bias. Results: The search found 1,417 records in the databases, of which 20 were selected for the final sample. Of these, 30 % were from 2020 (n = 6), published in Portuguese, English, and Spanish. Brazil had the highest number of publications, with 55 % (n = 11), and qualitative studies represented 55 % (n = 11) of the methodological approaches. The following thematic categories emerged from the analysis: "psychological and emotional elements," "human resources, materials, and infrastructure," "interpersonal relationships," "dissatisfaction," "violence in the workplace," and "overload." Conclusion: The precarious environment in PHC has a negative impact on nurses and the care provided to the population. Improvements in infrastructure, personnel, and work conditions are essential to ensure quality care.

Resumo Introdução: As atividades laborais incorporam elementos físicos, sociais, emocionais e técnicos. Em um cenário de constantes transformações, compreender a atualidade científica sobre a estrutura e sobre as circunstâncias laborais dos enfermeiros na Atenção Primária a Saúde (APS) se revela como imperativo. Objetivo: Identificar, na literatura científica, os aspectos relacionados ao ambiente de trabalho que influenciam a atuação dos enfermeiros inseridos na APS. Materiais e método: Se trata-se de revisão integrativa da literatura realizada em agosto de 2023 nas bases de dados Lilacs, Cinahl, Web of Science, Medline, Scopus e Embase, seguindo as recomendações do The Prisma 2020 Statement. Os critérios de inclusão foram artigos eletrônicos completos, em português, inglês ou espanhol, publicados entre 2019 e 2023. A presente revisão utilizou o instrumento Robis para avaliar o risco de viés. Resultados: A pesquisa identificou 1417 registros nas bases de dados, dos quais 20 foram selecionados para a amostra final. Desses, 30 % foram de 2020 (n = 6), em português, inglês e espanhol. O Brasil teve o maior número de publicações, com 55 % (n = 11), e os estudos qualitativos representaram 55 % (n = 11) na abordagem metodológica. Emergiram da análise as categorias temáticas "elementos psíquicos e emocionais", "recursos humanos, materiais e infraestrutura", "relações interpessoais", "insatisfação", "violência no local de trabalho" e "sobrecarga". Conclusões: O ambiente precário na APS impacta negativamente os enfermeiros e os cuidados a população. Melhorias na infraestrutura, na equipe e nas condições de trabalho são essenciais para garantir a qualidade no cuidado.

Resumen Introducción: Las actividades laborales incorporan elementos físicos, sociales, emocionales y técnicos. En un escenario de constante transformación, es imperativo conocer la literatura científica actual sobre la estructura y circunstancias laborales del equipo de enfermería en Atención Primaria de Salud (APS). Objetivo: Identificar, en la literatura científica, los aspectos relacionados con el ambiente de trabajo que influyen en la labor del equipo de enfermería en APS. Materiales y método: se trata de una revisión bibliográfica integradora realizada en agosto de 2023 en las bases de datos Lilacs, Cinahl, Web of Science, Medline, Scopus y Embase, siguiendo las recomendaciones de The Prisma 2020 Statement. Los criterios de inclusión fueron artículos electrónicos completos, en portugués, inglés o español, publicados entre 2019 y 2023. La revisión utilizó el instrumento Robis para evaluar el riesgo de sesgo. Resultados: La búsqueda identificó 1417 registros en las bases de datos, de los cuales 20 fueron seleccionados para la muestra final. De estos, el 30 % eran de 2020 (n = 6), en portugués, inglés y español. Brasil presentó el mayor número de publicaciones, con 55 % (n = 11), y los estudios cualitativos representaron 55 % (n = 11) del abordaje metodológico. Del análisis surgieron las siguientes categorías temáticas: "elementos psicológicos y emocionales", "recursos humanos, materiales e infraestructura", "relaciones interpersonales", "insatisfacción", "violencia en el trabajo" y "sobrecarga". Conclusiones: El entorno precario en la APS tiene un impacto negativo en los profesionales de enfermería y en la atención a la población. La mejora de las infraestructuras, la dotación de personal y las condiciones de trabajo son esenciales para garantizar una atención de calidad.

Abstract Information and Communication Technologies significantly benefit individuals and organizations but also bring negative consequences such as failures, overload, and stress. The quality of human-technology interaction is critical for success. IT mindfulness has emerged as a key factor associated with improvements in the use and performance of information systems, enhancing task-technology fit, satisfaction, and performance. This study aimed to translate, adapt, and validate the full and short versions of an IT mindfulness scale for Portugal. It used a national sample of 1107 higher education faculty members from a progressively digitized sector. Exploratory and confirmatory factor analyses were employed. As a result, two scales with robust psychometric properties were obtained, useful for contexts requiring brevity in application and valuable for both research and management practice, providing effective tools to understand and optimize human interaction with technology.

Resumo As Tecnologias de Informação e Comunicação oferecem benefícios significativos às pessoas e organizações, mas também geram consequências negativas, como falhas, sobrecarga e stress. A qualidade da interação pessoa-tecnologia é crítica para o sucesso. O IT mindfulness emergiu como um fator-chave associado a melhorias no uso e desempenho dos sistemas de informação, aumentando a adaptação tarefa-tecnologia, a satisfação e o desempenho. Este estudo visou traduzir, adaptar e validar as versões integral e reduzida de uma escala de IT mindfulness para Portugal e utilizou uma amostra nacional de 1107 docentes do ensino superior, setor progressivamente digitalizado. Recorreu-se a análise fatorial exploratória e confirmatória. Como resultado, obtiveram-se duas escalas com propriedades psicométricas robustas, úteis para contextos que requerem brevidade na aplicação e valiosas tanto para a investigação quanto para a prática da gestão, proporcionando instrumentos eficazes para compreender e otimizar a interação humana com a tecnologia.

ABSTRACT Background . Excessive consumption of salt (sodium chloride, NaCl) in the diet leads to the development of hypertension (HTN) and target organ damage. It is known that the ClC-K1 and ClC-5 channels are essential regulators of the chloride (Cl-) anion, but the contribution of this anion to salt-harmful effects remains unknown. Objective . The aim of this study was to evaluate the participation of Cl- in the renal inflammatory and oxidative response and in the development of HTN. Methods . Male Wistar rats were divided into four groups (n=8/group) and fed with different diets for 3 weeks. control (C group); NaCl 8% (NaCl group); high Na+ diet. sodium citrate (Na3C6H5O7) 11.8% (Na group); high Cl- diet. calcium chloride (CaCl2) 3.80%, potassium chloride (KCl) 3.06% and magnesium chloride (MgCl2) 1.30% (Cl group). Systolic blood pressure (SBP), renal function, oxidative stress and inflammation markers in the renal cortex, and renal expression of the chloride ClC-K1 and ClC-5 channels were assessed. Results . An increase in SBP, glutathione peroxidase (GPx) activity, and renal expression of nuclear factor kappa B (NFkB) and angiotensin II type 1 receptor (AT1R) were observed in the NaCl and Cl groups (p<0.05). The production of thiobarbituric acid reactive substances (TBARS) increased in the experimental groups compared with C. The expression of Parkinson disease protein 7 (PARK7) decreased in the Cl group compared with C (p< 0.05). The NaCl and Cl groups showed increased expression of ClC-K1, while ClC-5 was reduced in the NaCl group compared with C (p<0.05) Conclusion . Cl- would be co-responsible together with Na+ in triggering oxidative and inflammatory kidney damage and increasing blood pressure. This indicates the importance of reducing the intake of both ions as a non-pharmacological preventive measure for the prevention and control of HTN. The role of ClC-K1 and ClC-5 channels as mediators of this process remains to be confirmed.

RESUMEN Introducción . El consumo excesivo de sal (cloruro de sodio, NaCl) en la dieta conduce al desarrollo de hipertensión arterial (HTA) y daño de órgano blanco. Se sabe que los canales ClC-K1 y ClC-5 son reguladores esenciales del anión cloruro (Cl-), pero la contribución de este anión a los efectos deletéreos de la sal es aún desconocida. Objetivo . El objetivo de este trabajo fue evaluar la participación del Cl- en la respuesta inflamatoria y oxidativa renal y en el desarrollo de HTA. Material y métodos . Ratas Wistar macho se dividieron en cuatro grupos (n=8/grupo) y se alimentaron con diferentes dietas durante 3 semanas. control (grupo C); NaCl 8 % (grupo NaCl); dieta alta en Na+. citrato de sodio (Na3C6H5O7) 11,8 % (grupo Na); dieta alta en Cl-. cloruro de calcio (CaCl2) 3,80 %, cloruro de potasio (KCl) 3,06 % y cloruro de magnesio (MgCl2) 1,30 % (grupo Cl). Se determinó la presión arterial sistólica (PAS), función renal, marcadores de estrés oxidativo y de inflamación en corteza renal, y la expresion renal de los canales de cloruro ClC-K1 y ClC-5. Resultados . Se observó un aumento de la PAS, actividad de glutatión peroxidasa (GPx) y expresión renal de factor nuclear kappa B (NFkB) y receptor de angiotensina II tipo 1 (AT1R) en los grupos NaCl y Cl- (p<0,05). La producción de sustancias reactivas del ácido tiobarbitúrico (TBARS) aumentó en los grupos experimentales con respecto a C. La expresión de la proteína de Parkinson 7 (PARK7) disminuyó en el grupo Cl en comparación con C (p< 0,05). Los grupos NaCl y Cl- mostraron una mayor expresión de ClC-K1, mientras que ClC-5 se redujo en el grupo NaCl en comparación con C (p<0,05). Conclusión . El Cl- sería corresponsable, junto con el Na+, de desencadenar daño oxidativo e inflamatorio renal y aumentar la presión arterial; por ello se deduce la importancia de reducir la ingesta de ambos iones como medida preventiva no farmacológica para la prevención y control de la HTA. El rol de los canales ClC-K1 y ClC-5 como mediadores de este proceso queda aún por confirmarse.

ABSTRACT Objective: To determine the relationship between the level of quality of life and the level of overload in family caregivers. Method: Descriptive-correlational design, the sampling was simple random probabilistic and the sample of 100 primary caregivers. Results: The average age was 46.65 (DE= 14,050), 70% are female, with an average of 7.52 hours per day dedicated to care (DE= 6,820). 75% of the participants did not present it. Likewise, there are negative and significant correlations between overload and physical well-being (r= -.337; p <.001), psychological well-being (r= -.388; p <.001), social well-being (r= - .287; p <.001) and spiritual well-being (r= -.246; p= .014). Conclusion: The overload in family caregivers is related to the quality of life in the study participants.

RESUMEN Objetivo: Determinar la relación entre el nivel de calidad de vida y el nivel de sobrecarga en cuidadores familiares. Método: Diseño descriptivo-correlacional, el muestreo fue probabilístico aleatorio simple y la muestra de 100 cuidadores primarios. Resultados: La media de edad fue 46.65 (DE= 14.050), 70 % eran del sexo femenino, con una media de horas al día dedicadas al cuidado de 7.52 horas (DE = 6.820). El 75% de los participantes no presentó sobrecarga. Así mismo, se encontraron correlaciones negativas y significativas entre la sobrecarga y el bienestar físico (r= -.337; p <.001), el bienestar psicológico (r= -.388; p <.001), el bienestar social (r= -.287; p <.001) y bienestar espiritual (r= -.246; p= .014). Conclusión: La sobrecarga en cuidadores familiares se relaciona con la calidad de vida en los participantes del estudio.

Abstract The COVID 19 pandemic generated consequences for children, reflecting the social and psychological impact worldwide due to changes such as the absence of face-to-face classes and the transfer of education to homes. This not only represented a challenge for children, but also for families and educational institutions, who are in charge of the development of children's emotional regulation. This qualitative research based on grounded theory, aims to analyze the role of protective and risk factors related to the development of emotional regulation in children aged 4 and 5 years that were present during the context of remote education due to the COVID-19 pandemic. in 2020. For this, 5 interviews were conducted virtually with staff from an educational institution, as well as with 2 mothers of students who were in preschool in 2020, and a focus group with 5 mothers. In addition, an in-person activity was carried out with two groups of children, lasting approximately 40 minutes with each group, who were taught the story of the “Color Monster” to talk and identify emotions, as well as a space to paint and develop a dialogue, which allowed us to know their perspective of the pandemic, and the labeling of emotions they have. Protective and risk factors were also identified, such as listening to and discussing emotions, communication between family and school, support in the educational process, among others. It is concluded that, similar to international studies, this situation caused changes in daily routines, eating, sleeping, socialization with peers, and childhood emotions. For families it meant assuming a new role as educators for which they were not prepared. Both teachers and families highlighted the overload experienced. Protective and risk factors were identified such as listening to and discussing emotions, communication between family and school, support in the educational process, among others.

Resumen La pandemia por COVID 19 generó consecuencias en la niñez. La afectación a nivel social y psicológico se reflejó mundialmente debido a cambios como la ausencia de clases presenciales y el traslado de la educación a los hogares. Esto no solo significó un reto para la niñez, sino también para las familias y para las instituciones educativas a cargo del desarrollo de la regulación emocional de esta. Esta investigación, de corte cualitativo y abordada según la teoría fundamentada, analiza el papel de los factores protectores y riesgosos relacionados con el desarrollo de la regulación emocional en niñez de 4 y 5 años, que estuvo presente durante el contexto de la educación remota por motivo de la pandemia por COVID-19 en el año 2020. Para esto se realizaron 5 entrevistas virtuales con personal de una institución educativa, con 2 madres de estudiantes que estuvieron en preescolar en el año 2020, y con un grupo focal de 5 madres. Además, se realizó una actividad presencial de aproximadamente 40 minutos con dos grupos de estudiantes, a quienes se les enseñó el cuento “Monstruo de colores” para conversar e identificar emociones. Asimismo, se abrió un espacio para pintar y desarrollar un diálogo con el fin de conocer la perspectiva de la pandemia y el etiquetamiento de emociones que poseían. Se concluyó que, de manera similar a estudios internacionales, esta situación desencadenó cambios en rutinas cotidianas, alimentación, sueño, socialización con pares y cambios en las emociones de la niñez. A su vez, para las familias, supuso asumir un nuevo rol como personas educadoras para el cual no estaban preparadas. Se identificaron factores protectores y riesgosos como la escucha y el diálogo de las emociones, la comunicación entre familia y escuela, el apoyo en el proceso educativo, entre otros.

Abstract Invisibility is an issue that requires more attention among healthcare professionals, as some activities in Primary Care go unnoticed. One example is the offer of complementary therapies, whose implementation has been frail and, consequently, can be overlooked in the Unified Health System. This study aims to understand the factors contributing to the public invisibility of Integrative and Complementary Practices in Primary Care. It is a descriptive, exploratory, and qualitative research involving semi-structured interviews with 20 professionals in the Metropolitan Region of Goiânia. Thematic content analysis was applied to the interviews, revealing elements indicating the public invisibility of these practices, such as insufficient discussion in team meetings, inconsistency in the recording in user files, and low prioritization in implementation. In the interviews, social humiliation, a product of public invisibility, can also be perceived due to overload, embarrassments, and lack of physical space for the provision of practices to the users. It is concluded that Integrative and Complementary Practices are often overlooked in Primary Care. unnoticed therapies consequently System descriptive exploratory semistructured semi structured 2 Goiânia meetings files humiliation overload embarrassments users

Resumo A invisibilidade é uma questão que necessita de maior atenção entre os profissionais de saúde, pois algumas atividades na Atenção Primária passam despercebidas. Um exemplo é a oferta de terapias complementares, cuja implementação tem sido frágil e, consequentemente, pode ser invisibilizada no Sistema Único de Saúde. Este estudo visa compreender os fatores que contribuem para a invisibilidade pública das Práticas Integrativas e Complementares na Atenção Primária. Trata-se de uma pesquisa descritiva, exploratória e qualitativa, envolvendo entrevistas semiestruturadas com 20 profissionais na Região Metropolitana de Goiânia. A análise de conteúdo temática foi aplicada às entrevistas, revelando elementos que indicam a invisibilidade pública dessas práticas, como a falta de discussão nas reuniões de equipe, a desuniformidade no registro nos prontuários dos usuários e a baixa priorização na implementação. Nas entrevistas, a humilhação social, produto da invisibilidade pública, também pode ser percebida devido à sobrecarga, constrangimentos e falta de espaço físico para a oferta das práticas aos usuários. Conclui-se que as Práticas Integrativas e Complementares são frequentemente invisibilizadas na Atenção Primária. saúde despercebidas complementares consequentemente Saúde Tratase Trata se descritiva qualitativa 2 Goiânia equipe social sobrecarga Concluise Conclui

ABSTRACT Introduction/framework/objectives After a few years of exposure to different strains of COVID-19, there is a large percentage of infected individuals worldwide, most of whom are of working age. Taking into account that in a substantial fraction of these there were prolonged symptoms and with some capacity to alter work capacity, a review was initiated in order to summarize the most pertinent information published on this subject. Methodology This is a Bibliographic Review, initiated through a search carried out in April 2023, in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content This syndrome is a set of multiorgan symptoms/sequelae that affects previously infected individuals, sometimes lasting several months. It is a chronic complication, due to a persistent hyperinflammatory state (although the pathophysiology is not clearly known) and even after the COVID test is negative. It may be justified by inflammatory, hypoxic, microvascular and neurodegenerative changes; by direct damage caused by the virus itself and/or by secondary effects of therapy and co-existing morbidities. The emotional part may be associated with the fear of infecting family members, the economic problems associated with the costs of medical care (in countries with more privatized healthcare systems) and/or the stigma of the infection itself. The diagnosis is clinical and appears both in individuals who have been hospitalized and who have not. It can involve morbidity, overload on the health system and financial resources. It is also called Long COVID Syndrome, a term that actually emerged on social media. Discussion and Conclusions Given the temporality, the articles published on the topic are reasonably recent, and there is no previous bibliography on this subject to discuss the data obtained; although some symptoms may also be due to other more prevalent and/or old infections, possibly due to a similar pathophysiological mechanism. All evolutions are possible: from asymptomatic individuals during and after the infection to others with very debilitating symptoms that limit their ability to work. It is necessary for the occupational health team to evaluate each case, using the aptitude classification to help adapt tasks and obtain greater performance, job satisfaction and profit.

RESUMO Introdução/enquadramento/objetivos Após alguns anos de exposição às diversas estirpes de COVID-19, existe uma grande percentagem de indivíduos infetados mundialmente, grande parte dos quais em idade ativa. Tendo em conta que numa fração substancial destes existiram sintomas prolongados e com alguma influência para alterar a capacidade de trabalho, iniciou-se uma revisão, no sentido de resumir o que mais pertinente se publicou sobre este assunto. Metodologia Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023, nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo Esta síndroma é um conjunto de semiologia multiorgânica que atinge indivíduos previamente infetados, por vezes com duração de vários meses. Trata-se de uma complicação crónica, devido a um estado hiperinflamatório persistente (ainda que a patofisiologia não seja conhecida com clareza) e mesmo após o teste de COVID negativar. Poderá ser justificada através de alterações inflamatórias, hipóxicas, microvasculares e neurodegenerativas; bem como devido aos danos diretos causados pelo vírus em si e/ou pelos efeitos secundários da terapêutica e morbilidades coexistentes. A parte emocional poderá ser associada ao medo de infetar familiares, pelos problemas económicos associados aos custos dos cuidados médicos (em países com sistemas de saúde mais privatizados) e/ou pelo estigma da infeção em si. O diagnóstico é clínico e tanto aparece em indivíduos que foram hospitalizados, como não. Pode implicar morbilidade, sobrecarga do sistema de saúde e de recursos financeiros. Também se designa por Síndroma do COVID longo, termo que, na realidade, surgiu nas redes sociais. Discussão e Conclusões Dada a temporalidade, os artigos publicados sobre o tema são razoavelmente recentes, não existindo bibliografia anterior sobre este assunto, para discutir os dados obtidos; ainda que alguns sintomas equivalentes também possam ser consequentes a outras infeções, mais prevalentes e/ou antigas, eventualmente por um mecanismo fisiopatológico parecido. Todas as evoluções são possíveis, desde indivíduos assintomáticos durante e após a infeção, como outros com sintomas muito debilitantes e limitadores da sua capacidade laboral. É necessário que a equipa de saúde ocupacional avalie cada caso, usando a classificação de aptidão para ajudar na adequação das tarefas e obtenção de maior desempenho, satisfação laboral e lucro.