ABSTRACT We report the case of a patient with psoriasis vulgaris who presented worsening of the disease after infection with Chikungunya, with no improvement of the outbreak with the usual treatment for psoriasis, in whom a diagnosis of classic Hodgkin lymphoma was subsequently made. Chemotherapy treatment was started and a complete improvement of the skin lesions of psoriasis was observed.

RESUMEN Divulgamos el caso de una paciente con psoriasis vulgar que presento empeoramiento de la misma luego de infección por Chikungunya, sin mejoría del brote con el tratamiento habitual de la psoriasis, en quien posteriormente se realiza el diagnóstico de Linfoma Hodgkin tipo clásico. Se inició tratamiento quimioterápico y se observó una mejoría completa de las lesiones cutáneas de la psoriasis.

Abstract Introduction: In December 2016, an outbreak of sylvatic yellow fever (YF) occurred in the non-endemic areas of the south-eastern region of Brazil. The immune response to the yellow fever vaccine and its safety in individuals with chronic kidney disease (CKD) living in YF-endemic regions are not thoroughly understood. The objective of this study is to assess the incidence of adverse events and the serological response after primary vaccination with the 17DD-YF vaccine in CKD patients undergoing dialysis. Methods: This was a multicenter, retrospective cohort study involving 223 individuals with CKD who were on dialysis after primary vaccination against YF. Clinical and epidemiologic characteristics were collected and the vaccine adverse event (VAE) were assessed. Around 35 months after vaccination, the serological response was evaluated in 71 (32%) patients using neutralization tests. Results: No serious VAE occurred in any patient. Local reactions were reported in 13 individuals (5.8%), while 6 (2.7%) reported generalized systemic reactions and 205 (91.9%) did not display any VAE. No clinical or epidemiologic characteristic predicted the occurrence of VAE. Adequate serological response was found in 38% of participants and none of the clinical or epidemiological characteristics were associated with immunogenicity. Conclusion: The outcomes of our study suggest that the yellow YF vaccine is well-tolerated in CKD patients undergoing dialysis, but it does not induce adequate immune response. Future research should focus on evaluating both cellular and humoral immune responses following administration of various doses of the YF vaccine. Introduction 2016 (YF nonendemic non endemic southeastern south eastern Brazil (CKD YFendemic understood 17DDYF DDYF 17DD DD Methods multicenter 22 (VAE assessed 3 7 32% 32 (32% tests Results patient 1 5.8%, 58 5.8% , 5 8 (5.8%) 2.7% 27 2 (2.7% 20 91.9% 919 91 9 (91.9% 38 immunogenicity Conclusion welltolerated well tolerated 201 (32 5.8 (5.8% 2.7 (2.7 91.9 (91.9 (3 5. (5.8 2. (2. 91. (91. ( (5. (2 (91 (5 (9

Resumo Introdução: Em dezembro de 2016, houve um surto de febre amarela (FA) silvestre em áreas não endêmicas da região sudeste do Brasil. A resposta imunológica à vacina contra FA e sua segurança em indivíduos com doença renal crônica (DRC) que vivem em regiões endêmicas de febre amarela não são totalmente compreendidas. O objetivo deste estudo foi avaliar a incidência de eventos adversos e a resposta sorológica após vacinação primária com a vacina 17DD-YF em pacientes com DRC submetidos à diálise. Métodos: Este foi um estudo de coorte retrospectivo e multicêntrico envolvendo 223 indivíduos com DRC que estavam em diálise após vacinação primária contra FA. Foram coletadas características clínicas, epidemiológicas e avaliados os eventos adversos da vacina (EAV). Cerca de 35 meses após a vacinação, a resposta sorológica foi avaliada em 71 (32%) pacientes usando testes de neutralização. Resultados: Não houve EAV grave em nenhum paciente. Reações locais foram relatadas em 13 indivíduos (5,8%), enquanto 6 (2,7%) relataram reações sistêmicas generalizadas e 205 (91,9%) não apresentaram nenhum EAV. Nenhuma característica clínica ou epidemiológica predisse a ocorrência de EAV. Uma resposta sorológica adequada foi encontrada em 38% dos participantes e nenhuma das características clínicas ou epidemiológicas foi associada à imunogenicidade. Conclusão: Os desfechos de nosso estudo sugerem que a vacina contra FA é bem tolerada em pacientes com DRC em diálise, mas não induz uma resposta imunológica adequada. Pesquisas futuras devem se concentrar na avaliação das respostas imunes tanto celulares quanto humorais após a administração de várias doses da vacina contra FA. Introdução 2016 (FA Brasil (DRC compreendidas 17DDYF DDYF 17DD YF DD Métodos 22 . (EAV) 3 7 32% 32 (32% neutralização Resultados paciente 1 5,8%, 58 5,8% , 5 8 (5,8%) 2,7% 27 2 (2,7% 20 91,9% 919 91 9 (91,9% 38 imunogenicidade Conclusão 201 (EAV (32 5,8 (5,8% 2,7 (2,7 91,9 (91,9 (3 5, (5,8 2, (2, 91, (91, ( (5, (2 (91 (5 (9

RESUMEN Para las economías en desarrollo el diseño de políticas con respecto al financiamiento externo es realmente complejo. El estallido y posterior evolución de la crisis derivada de la pandemia de COVID-19 a inicios del 2020 afectó, en primer lugar, a las economías en desarrollo que debieron enfrentarse a una compleja situación interna y restricción al financiamiento internacional. El presente trabajo describe el complejo escenario internacional que dificulta el acceso al financiamiento externo y se detiene en el caso cubano, en el cual un conjunto de factores internos y externos dificultan de manera extrema el acceso a recursos financieros imprescindibles para la recuperación y el desarrollo del país. El análisis se centra en el financiamiento proveniente de fuentes privadas y en particular en dos de sus principales instrumentos, la inversión extranjera directa y las remesas.

ABSTRAC For developing economies, the design of policies regarding external financing is really complex. The outbreak and subsequent evolution of the crisis derived from the outbreak of the COVID-19 pandemic at the beginning of 2020 affected, first of all, developing economies that had to face a complex internal situation and restriction on international financing. This work describes the complex international scenario that makes access to external financing difficult and focuses on the Cuban case in which a set of internal and external factors make it extremely difficult to access essential financial resources for recovery and development from the country. The analysis focuses on financing from private sources and in particular on two of its main instruments, foreign direct investment and remittances.

Objetivo: Esse estudo teve por objetivo investigar um surto de covid-19 entre PS no serviço de nefrologia de um hospital universitário no Rio de Janeiro em março de 2020 e identificar fatores de risco para infecção pelo SARS-CoV-2. Métodos: Para caracterizar o surto em relação a tríade pessoa-lugar-tempo foi definida como população fonte uma equipe de 59 PS, que foram recrutados e submetidos a entrevistas digitais para reconhecer a ocorrência de sinais e sintomas, comorbidades, de hospitalização durante o período de 1 a 23 de março de 2020. A análise dos dados consistiu na construção e interpretação da curva epidêmica e na identificação de fatores de risco para a infecção durante o surto. Resultados: Dos 59 profissionais do serviço de nefrologia, 43 (73%) participaram do estudo. Eram predominatemente médicos (58%), do sexo feminino (67%), com idade variando de 24 a 69 anos e média de 40 anos. O surto ocorreu entre 1º de março e 23 de março de 2020 e teve pico em 12 e 13 de março. Trinta e dois participantes foram classificados com casos prováveis ​​ou confirmados de covid-19. Entre os casos predominavam mulheres (71%), com idade de 37 anos, predominantemente médicos (45%). Apenas um participante foi hospitalizado. Fatores de risco para covid-19 foram ser médico, trabalhar em outro hospital e ser mulher. Conclusão: Concluímos que houve um surto de covid-19 entre profissionais de saúde do serviço de nefrologia do HUPE em março de 2020. Foram sugeridas medidas de proteção a todos profissionais e exames para infeção para SARS-CoV-2 nos sintomáticos.

Objetivo: Este estudio tuvo como objetivo investigar un brote de covid-19 entre el personal sanitario del servicio de nefrología de un hospital universitario de Río de Janeiro en marzo de 2020 e identificar factores de riesgo para la infección por SARS-CoV-2. Métodos: Para caracterizar el brote en relación con la tríada persona-lugar-tiempo, se definió como población fuente un equipo de 59 PS, quienes fueron reclutados y sometidos a entrevistas digitales para reconocer la aparición de signos y síntomas, comorbilidades y hospitalización. durante el período del 1 al 23 de marzo de 2020. El análisis de datos consistió en construir e interpretar la curva epidémica e identificar factores de riesgo de infección durante el brote. Resultados: De los 59 profesionales del servicio de nefrología, participaron del estudio 43 (73%). Eran predominantemente médicos (58%), mujeres (67%), con edades comprendidas entre 24 y 69 años y una media de 40 años. El brote se produjo entre el 1 y el 23 de marzo de 2020 y alcanzó su punto máximo el 12 y 13 de marzo. Treinta y dos participantes fueron clasificados como casos probables o confirmados de covid-19. Entre los casos predominaron las mujeres (71%), con edad de 37 años, predominantemente médicos (45%). Sólo un participante fue hospitalizado. Los factores de riesgo para el Covid-19 fueron ser médico, trabajar en otro hospital y ser mujer. Conclusión: Concluimos que hubo un brote de covid-19 entre los profesionales de la salud del servicio de nefrología del HUPE en marzo de 2020. Se sugirieron medidas de protección para todos los profesionales y pruebas de infección por SARS-CoV-2 en pacientes sintomáticos.

Objective: This study aimed to investigate a COVID-19 outbreak among HCWs in the nephrology department of a university hospital in Rio de Janeiro in March 2020 and to identify risk factors for SARS-CoV-2 infection. Methods: To characterize the outbreak in relation to the person-place-time triad, a team of 59 HCWs was defined as the source population. They were recruited and submitted to digital interviews to recognize the occurrence of signs and symptoms, comorbidities, and hospitalization during the period from March 1 to 23, 2020. Data analysis consisted of constructing and interpreting the epidemic curve and identifying risk factors for infection during the outbreak. Results: Of the 59 professionals in the nephrology department, 43 (73%) participated in the study. They were predominantly physicians (58%), female (67%), with an age ranging from 24 to 69 years, and an average of 40 years. The outbreak occurred between March 1 and March 23, 2020, and peaked on March 12 and 13. Thirty-two participants were classified as having probable or confirmed cases of COVID-19. The majority of cases were women (71%), aged 37 years, and predominantly physicians (45%). Only one participant was hospitalized. Risk factors for COVID-19 were being a physician, working in another hospital, and being a woman. Conclusion: We conclude that there was an outbreak of COVID-19 among healthcare professionals in the nephrology department of HUPE in March 2020. Protective measures were suggested for all professionals and tests for SARS-CoV-2 infection in symptomatic individuals.

ABSTRACT Cercospora leaf spot (CLS) disease and bruchids are the common disease and insect pest causing yield loss in mung bean (Vigna radiata (L.) R. Wilczek). ‘KUML4’ is an improved mung bean cultivar grown in Thailand having high yield, early and highly synchronous maturity, large seed size, but susceptible to CLS disease and bruchids. This study was conducted to improve ‘KUML4’ through introgression of VrTAF5 for CLS resistance and VrPGIP2 for bruchid (Callosobruchus maculatus) resistance from landrace mung bean accessions ‘V4718’ and ‘V2808’, respectively, by marker-assisted backcrossing (MABC). In the MABC, foreground selections were performed using VrTAF5- and VrPGIP2-specific markers. The BC3F3 pyramided lines with KUML4 background carrying both VrTAF5 and VrPGIP2 genes were developed and evaluated for agronomic and yield-related traits, CLS resistance, and bruchid resistance. Three BC3F3 lines, KUML4-2020-21, KUML4-2020-23, and KUML4-2020-60, exhibiting superior agronomic and yield-related traits, CLS resistance, and bruchid resistance than ‘KUML4’ were successfully obtained via MABC. Under the CLS outbreak, these lines showed 248.5%-331.7% higher seed yield than ‘KUML4’. The lines expressed nearly perfect resistance to bruchid (< 5% seeds damaged). These lines can be developed into new resistant mung bean cultivars in the future.

ABSTRACT Objectives. To analyze the evolution of COVID-19 in rural populations of Loreto and Ucayali in the early stage of the pandemic. Materials and methods. A community-level longitudinal observational study was conducted and based on two rounds of telephone surveys with local authorities of more than 400 indigenous and non-indigenous rural communities in Loreto and Ucayali, in July and August 2020. We collected information on cases and deaths by COVID-19 in their communities, protective measures adopted and if state assistance was received in the early stage of the pandemic. Descriptive statistics allowed us to evaluate the evolution of the pandemic after the initial outbreak and compare the trends of the two regions, as well as between indigenous and non-indigenous populations. Results. In July 2020, COVID-19 had reached 91.5% of the communities, although deaths from COVID-19 were reported in 13.0% of the communities, with rural mortality being higher in Ucayali (0.111%) than in Loreto (0.047%) and in non-indigenous communities. By August, prevalence decreased from 44.0% to 32.0% of communities, but became more frequent in indigenous communities, and those in Ucayali. Traveling to the city to receive state bonuses and difficulties maintaining social distancing contributed to the spread. Conclusions. Our findings show the evolution of COVID-19 in rural communities and point to important areas of attention in future public policies, for the adoption of protective measures and reconsidering strategies for the distribution of assistance in the face of future pandemics.

RESUMEN Objetivos. Analizar la evolución del COVID-19 en poblaciones rurales de Loreto y Ucayali en la etapa temprana de la pandemia. Materiales y métodos. Se realizó un estudio observacional longitudinal a nivel de comunidades basado en dos rondas de encuestas telefónicas con autoridades locales de más de 400 comunidades rurales indígenas y no-indígenas en Loreto y Ucayali, en julio y agosto de 2020, para recopilar información sobre casos y muertes por COVID-19 en sus comunidades, medidas de protección adoptadas y la recepción de asistencia estatal en la etapa temprana de la pandemia. Estadísticas descriptivas permiten evaluar la evolución de la pandemia después del brote inicial y comparar las tendencias de las dos regiones, así como entre poblaciones indígenas y no-indígenas. Resultados. En julio de 2020, el COVID-19 había llegado al 91,5% de las comunidades, aunque se reportaron muertes por COVID-19 en 13,0% de las comunidades, siendo la mortalidad rural mayor en Ucayali (0,111%) que en Loreto (0,047%) y en comunidades no-indígenas. Para agosto, la prevalencia disminuyó de 44,0% a 32,0% de comunidades, pero se volvió más frecuente en las comunidades indígenas, y aquellas en Ucayali. Viajar a la ciudad para recibir bonos estatales y las dificultades para mantener el distanciamiento social contribuyeron al contagio. Conclusiones. Los hallazgos mostraron la evolución del COVID-19 en comunidades rurales y señalan áreas importantes de atención en futuras políticas públicas, para la adopción de medidas de protección y reconsiderar estrategias para la distribución de asistencia ante pandemias futuras.

RESUMEN Introducción: La covid-19 alteró la situación laboral y el proceso docente educativo de las universidades médicas. Además, hubo un impacto muy negativo en todas las esferas económicas y sociales del país. En el sector de la salud se reorganizaron los servicios y recursos humanos, se afectó la producción del cuadro básico de medicamentos, aumentaron las presiones sobre el sistema de salud pública y asistencia social con el correspondiente incremento de los costos de salud pública y gastos públicos. Objetivo: Describir los efectos sociales, económicos y académicos de la covid-19 en la Facultad de Medicina No. 1 de la Universidad de Ciencias Médicas en Santiago de Cuba. Métodos: Se realizó un estudio observacional, descriptivo, retrospectivo, durante rebrotes de covid-19 en el periodo de enero a julio de 2021 en trabajadores disponibles y estudiantes de primero a quinto año de la facultad. Se evaluaron características generales y socioeconómicas para cada grupo, como certificados médicos y causas, días afectados, resultados de la pesquisa, y actividad formativa. Se utilizó la estadística descriptiva para el análisis y presentación de los resultados. Resultados: La incidencia de casos positivos fue baja, pero generó miles de días de incapacidad, por aislamientos e ingreso en el hogar. Se pesquisaron más de 5 000 personas sospechosas de la enfermedad, de ellos 19,9 % resultó positivo. La promoción superó 95 % en todos los años de la carrera y fue mayor al de etapa prepidémica, al igual que la eficiencia vertical. Conclusiones: Aunque hubo efectos sociales, económicos y académicos negativos, el trabajo comunitario integral contribuyó a la preservación de la salud de la población y se desarrolló el aprendizaje a distancia.

ABSTRACT Introduction: The COVID-19 altered the employment situation and the educational teaching process of medical universities. In addition, there was a very negative impact on all economic and social areas of the country. In the health sector, services and human resources were reorganized, the production of basic medicines was affected, pressures on the public health and social welfare system increased with corresponding rise in public health costs and expenditures. Objective: To describe the social, economic and academic effects of COVID-19 in the Medical Faculty No. 1 of the Medical Science University in Santiago de Cuba. Methods: An observational, descriptive, retrospective study was conducted during the reoutbreaks of COVID-19 in the period from January to July 2021 in available workers and students from the first to the fifth year of the faculty. General and socio-economic characteristics were evaluated for each group, such as medical certificates and causes, affected days, research results and training activity. Descriptive statistics were used for the analysis and presentation of results. Results: The incidence of positive cases was low, but generated thousands of days of disability due to isolation and home intake. More than 5 000 people suspected pf the disease were surveyed, 19.9 % of them positive. The promotion exceeded 95 % in all years of the major and was higher than the pre-epidemic stage, as well as the vertical efficiency. Conclusions: Although there were negative social, economic and academic effects, the integral community work contributed to the preservation of the population´s health and online classes were developed.

RESUMEN En el presente texto, analizo las demandas que originan las revueltas populares del 18 de octubre de 2019, caracterizándolas como una impugnación contra la tríada colonialidad, patriarcado y neoliberalismo. Luego, indago en la relación de continuidad que existe entredicha impugnación y las actorías que se posicionan en los espacios abiertos como respuesta institucional a la crisis: la redacción de una nueva Constitución. Esta continuidad se plasma en un proceso constituyente que incluye las demandas antes referidas, mediante escaños reservados para los pueblos indígenas (colonialidad), paridad de género (patriarcado) y listas de independientes (neoliberalismo). Dicha continuidad desde el estallido social a la salida institucional, se verifica también en la figura de Elisa Loncón Antileo, elegida presidenta de la Convención constitucional, como un símbolo deesa tríada de dominación impugnada, en su condición de mujer mapuche de origen proletario y sin afiliación partidaria; un carácter simbólico que se refrenda en el discurso inaugural que brinda al ser electa. Por último, daré una mirada a las investigaciones en ciencias sociales que abordan la tríada en comento, como superposición de raza, clase, género y sexualidad, primero en la noción de interseccionalidad, y luego en las aportaciones del feminismo de colonial.

ABSTRACT In this text, I analyze the demands that originate the popular revolts of October 18, 2019, characterizing them as a challenge against the triad of coloniality, patriarchy and neoliberalism. Then, I inquire into the continuity relationship that exists between said challenge and the actors that position themselves in open spaces as an institutional response to the crisis: the drafting of a new Constitution. This continuity is reflected in a constituent process that includes the aforementioned demands, through reserved seats for indigenous peoples (coloniality), gender parity (patriarchy) and lists of independents (neoliberalism). Likewise, the transition between the social outbreak and the institutional exit makes it possible for the figure of Elisa Loncón Antileo, president of the Constitutional Convention, to emerge as a symbol of this contested triad of domination; This symbolic character of Loncíon is endorsed in the inaugural speech she gives when she is elected. Finally, I will take a look at the research in the social sciences and humanities that have reviewed the triad in question, from the perspective of the overlap of race, class, gender and sexuality, first from the notion of intersectionality, and then on the contributions of the decolonial feminism.

The COVID-19 outbreak has changed pedagogical choices in the teaching of English. Social media has become one of the alternatives in mediating and assisting virtual teaching and learning. With the study reported on here we aimed to investigate the use of social media in the teaching of English during the COVID-19 pandemic in Indonesian schools. In this exploratory study we employed a 40-item questionnaire focusing on the types of social media used, skills taught, problems encountered, and how these were managed. The respondents were 158 English teachers from 34 provinces in Indonesia. The data were analysed quantitatively and qualitatively to generate interactive and comprehensive data. From the study it became clear that the most frequently used social media platforms in Indonesia were WhatsApp, YouTube, and Instagram. The combination of social media was found to be a suitable platform to employ for acquiring all English skills. Reasons for the use of social media range from practicality to teachers' familiarity. Teachers' teaching experience tended to influence the reasons why social media were used. The results of our study reveal that the internet networks, learners' readiness as well as parents' support were challenges encountered by learners. To solve these problems, teachers implemented some alternative social media platforms and communicated with parents to enhance English teaching during the pandemic.

Resumen El accidente cerebrovascular (ACV) es la principal causa de discapacidad y la tercera causa de mortalidad en nuestro país. Argentina y la región de las Américas se encuentran atravesando el peor brote epidémico de dengue del que se tenga registro, con una importan te demanda en el sistema de salud. El dengue podría aumentar el riesgo de ACV y dada la naturaleza tiem po dependiente del manejo de esta enfermedad para reducir la morbilidad y mortalidad, y las potenciales consideraciones a tener en cuenta en los pacientes con dengue, se presenta una revisión breve de la literatura con puntos de incertidumbre y aspectos a considerar en el protocolo o código de ACV, considerando las ca racterísticas clínicas y alta demanda del sistema de salud provocada por el dengue. Se realiza también un llamado a generar evidencia sobre el manejo del ACV en pacientes con dengue.

Abstract Stroke is the leading cause of disability and the third leading cause of mortality in our country. Argentina and the Region of the Americas are going through the worst epidemic outbreak of dengue on record with significant demand on the health system. Dengue could increase the risk of stroke and given the time-dependent nature of the management of this disease to reduce morbidity and mortality and the potential considerations to be taken into account in patients with dengue, we present a focused review of the literature with points of uncer tainty and aspects to be considered in the stroke code considering the clinical characteristics and high demand of the health system caused by the dengue fever. A call is also made to generate evidence on the management of stroke in patients with dengue.

The outbreak of the Covid-19 pandemic and subsequent lock-down restrictions forced higher education institutions to move towards a fully online mode of delivery. The study explored the teaching and learning experiences of both students and lecturers within such a digitally transformed higher education space. Concerns have however been raised about this sudden move towards the fourth industrial revolution due to the levels of readiness of higher education institutions. A qualitative research approach was followed, and I purposeful selected ten masters' course work students and two lecturers. One-on-one interviews and a focus group discussion were utilised for data generation. The Saldana's thematic method was employed to analyse data. The findings of my research point to both positive and negative experiences of students and lecturers, following the shift to online teaching and learning. Negative experiences highlight the need for support systems to be put in place in a digitally transformed educational milieu.

The resurgence of monkeypox, subsequent to its designation as a Public Health Emergency of International Concern by the World Health Organization in 2022, underscores the critical need for rigorous infection control protocols within dental settings. Due to the inherent nature of dental procedures, that involve working in close proximity to patients and potential exposure to infectious bodily fluids, the dental profession faces significant challenges in mitigating the transmission of mpox. This update provides a comprehensive review of the virological characteristics, transmission pathways, and clinical presentation of mpox, with particular emphasis on its oral manifestations and the implications for dental practitioners. It delineates both standard and enhanced infection control measures, including the application of personal protective equipment, stringent hand hygiene practices, meticulous environmental disinfection, and the prudent management of aerosol-generating procedures. Additionally, is addresses the importance of patient screening, isolation of suspected cases, and the education of both dental staff and patients regarding the transmission and prevention of mpox. The necessity for dental professionals to maintain vigilance, remain current with evolving guidelines, and implement comprehensive infection control strategies is emphasized, highlighting the pivotal role of dental practices in the early detection and control of mpox transmission during the ongoing outbreak.

Abstract Since its outbreak, the COVID-19 pandemic has cost millions of human lives and had an unprecedented negative impact on health systems worldwide. Although the administration of vaccines slowed the disease spread, there is still no treatment for critically ill patients. Part of this is due to our poor understanding of the pathophysiology of the disease. As is well known, SARS-CoV-2 infection causes multisystemic damage with a phenomenon known as immunothrombosis, which has been linked to an "old enemy," the neutrophil extracellular traps (NETs), which could be the source of endothelial damage and part of the prothrombotic state of the disease. Several studies documented the relationship between NET formation and the severity of the disease including the associated mortality. Based on this premise, it has been suggested that NET can be a therapeutic target; however, there have been very few studies on the topic, rendering us unable to draw firm conclusions. We believe that understanding the complex mechanism between NETs and SARS-CoV-2 infection may lead to a more robust theory, which, in turn facilitates the development of drugs able to curb the high mortality rate caused by this disease.

Resumen Desde su estallido, la pandemia de COVID-19 cobró millones de vidas humanas y tuvo un impacto negativo sin precedentes en los sistemas de salud de todo el mundo. Aunque la administración de vacunas frenó la propagación de la enfermedad, hasta la fecha no existe un tratamiento específico para los pacientes. Esto se debe, en parte, a nuestro escaso conocimiento de la fisiopatología de la enfermedad. La infección por SARS-CoV-2 causa daños multisistémicos con un fenómeno conocido como inmunotrombosis, que se ha relacionado con un "viejo enemigo", las trampas extracelulares de neutrófilos (en inglés: NETs), que podrían ser la fuente del daño endotelial y parte del estado protrombótico evidenciado. Varios estudios documentaron la relación entre la formación de NET y la gravedad de la enfermedad por SARS-CoV-2 e incluso la mortalidad causada por ella. Partiendo de esta premisa, se ha sugerido que las NETs puede ser una diana terapéutica; sin embargo, ha habido muy pocos estudios sobre el tema, lo que nos impide extraer conclusiones sólidas. Creemos que la comprensión del complejo mecanismo entre las NETs y el SARS-CoV-2 puede conducir a una teoría más sólida, que a su vez facilite el desarrollo de fármacos capaces de frenar la elevada mortalidad causada por esta enfermedad.

ABSTRACT: Polioencephalomalacia (PEM) is a nervous disease that affects ruminants, has a worldwide distribution and causes significant economic losses. PEM is abundantly described and studied in cattle and small ruminants, but there is little information about the disease in buffaloes, especially in Brazil. The objective of this work is to describe the clinical and pathological aspects of an outbreak of PEM in buffaloes in a feedlot in the state of Pará, Brazil. The outbreak occurred in a flock of 76 Murrah buffaloes, with an average age of five months, in a feedlot. Twenty-eight of these buffaloes became ill, and thirteen showed neurological signs and died. Two buffaloes underwent necropsy. The brain and fragments of various abdominal and thoracic cavity organs were fixed in 10% formalin and sent for histopathological examination. In the frontal, parietal, and occipital telencephalic lobes, the convolutions were flattened and yellowish, and when cut, there was a clear line of demarcation between the superficial and deep layers. Histologically, the intermediate layers of the cerebral cortex showed mild to moderate vacuolization of the neuropil, moderate enlargement of the perivascular, perineuronal, and periastrocyte spaces, moderate swelling and edema of astrocytes, and a large number of necrotic neurons. The work demonstrates that, despite being poorly documented in Brazil, PEM should be considered in the differential diagnosis of neurological syndromes in buffaloes. ABSTRACT (PEM ruminants losses Brazil Pará 7 months Twentyeight Twenty eight ill died necropsy 10 examination frontal parietal lobes yellowish cut Histologically neuropil perivascular perineuronal spaces astrocytes neurons 1

RESUMO: Polioencefalomalacia (PEM) é uma doença nervosa complexa que afeta ruminantes, tem distribuição mundial e causa perdas econômicas significativas. A PEM é abundantemente descrita e estudada em bovinos e pequenos ruminantes, porém há poucas informações sobre a doença em bubalinos, especialmente no Brasil. O objetivo deste trabalho é descrever os aspectos clínicos e patológicos de um surto de PEM em búfalos em um confinamento no estado do Pará, Brasil. O surto ocorreu em um lote de 76 búfalos da raça Murrah, com idade média de cinco meses, em um sistema de confinamento. Vinte e oito desses bubalinos adoeceram e treze apresentaram sinais neurológicos e morreram. Dois bubalinos foram submetidos à necropsia. O encéfalo e fragmentos de diversos órgãos da cavidade abdominal e torácica foram fixados em formol a 10% e enviados para exame histopatológico. Nos lobos frontal, parietal e occipital do telencéfalo as circunvoluções estavam achatadas e amareladas e ao corte havia uma clara linha de demarcação entre as camadas superficial e profunda. Na histologia as camadas intermediárias do córtex cerebral apresentavam vacuolização leve a moderada do neurópilo, aumento moderado dos espaços perivascular, perineuronal e periastrocitário, tumefação e edema moderados de astrócitos e grande número de neurônios necróticos. O trabalho demonstra que, apesar de pouco documentada no Brasil, a PEM deve ser considerada no diagnóstico diferencial das síndromes neurológicas em bubalinos. RESUMO (PEM ruminantes significativas Brasil Pará 7 Murrah meses morreram necropsia 10 histopatológico frontal profunda neurópilo perivascular periastrocitário necróticos 1

Resumen: El presente artículo analiza de forma descriptiva la evolución conceptual que ha tenido la educación superior chilena como concepto a partir de la perspectiva de Fernando Atria. En tal contexto, se empleó como punto de partida los siguientes textos: Neoliberalismo con rostro humano (2013), Derechos sociales y Educación (2014). Estos se contrastaron con algunas entrevistas más actualizadas con el fin de evidenciar la existencia de algún cambio significativo en torno a dicho concepto en una coyuntura pre estallido social (Octubre 2019) y post estallido. En ese sentido, resultó de especial significancia reflexionar este fenómeno sobre todo de cara a la discusión pública que gira alrededor de la redacción de la nueva constitución, así como los principales nudos conflictivos que giran alrededor de la consagración del acceso a la educación superior como un derecho constitucional inmaterializado. Por lo tanto, se buscó mostrar las tensiones desprendidas del proceso de transición del Atria intelectual académico hacia el político.

Abstract: This paper aims to conduct a descriptive analysis about the conceptual development that Chilean higher education has had from the perspective of Fernando Atria. We will use his texts; “Neoliberalism con rostro Humano” (2013) and “Derechos Socials and Education” (2014), as a starting point. They will be contrasted with some more up-to-date interviews, to determine the existence of any meaningful change around his higher education concept towards a context pre and post social outbreak (October 2019). Thus, it is of special significance to make reflections around the public discussion that involves the new Chilean constitution drafting, where Atria also won its seat as a conventional constituent. Therefore, it is sought in this process to show his transition from academic to political.