Evening primrose oil supplements are rich in omega-6 fatty acids, with emphasis on linoleic and γ-linolenic acids, being taken in the treatment and prevention of diseases, but mainly for the relief of symptoms caused by premenstrual tension and menopause in women. This study aimed to evaluate the quality of the lipid profile of evening primrose oil supplements using gas chromatography techniques with a flame ionization detector and mass spectrometry with electrospray ionization. For this, eight commercially available national evening primrose oil brands were used. Of the eight samples analyzed, only two met all the standards established in legislation for fatty acids. The remaining capsules were subjected to triacylglycerol analysis and using a calibration curve the presence of soybean oil in the composition of the evening primrose oil capsules was verified. From the triacylglycerol with a mass/charge ratio of 901, it was possible to identify the addition of 31.16-85.88% of soybean oil in six of the eight capsules, leading the consumer to ingest products that did not comply with current legislation. omega6 omega 6 omega- acids γlinolenic γ linolenic diseases women this used analyzed verified masscharge charge 901 31.1685.88% 31168588 31.16 85.88% 31 16 85 88 31.16-85.88 90 1685 31.1685.88 3116858 3116 31.1 8588 85.88 3 1 8 31.16-85.8 9 168 31.1685.8 311685 311 31. 858 85.8 31.16-85. 31.1685. 31168 85. 31.16-85 31.1685 31.16-8 31.168 31.16-

Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the brain, and inhibiting this enzyme can reduce oxidative stress, stabilize neurotransmitter levels, and alleviate symptoms. In this context, a pharmacophoric model was created using PharmaGist with 31 hits extracted from BindingDB to enable a pharmacophoric-based search of potential MAO-B inhibitors in ZincPharmer’s chemical space, followed by the building of 10 conformers for each molecule in the software OMEGA, screening for structural and electrostatic similarity to safinamide using ROCS (Rapid overlay of chemical structures) and EON (Electrostatic similarity for lead-hopping), respectively. In addition, the molecular docking with Gold using the score function was performed to rank the ligands with the highest probabilities of affinity to MAO-B and then discriminate those with suitable physical chemical, pharmacokinetic, and toxicological features using the tools QikProp, SwissADME, and DEREK. Four potential ligands with selective MAO-B inhibitor properties were identified, which show promise as future therapeutic agents for MAO-B-related disorders. Worldwide schizophrenia depression diseases MAOB MAO (MAO-B brain stress levels symptoms context 3 pharmacophoricbased based ZincPharmers ZincPharmer s space 1 OMEGA Rapid structures Electrostatic leadhopping, leadhopping lead hopping , lead-hopping) respectively addition pharmacokinetic QikProp SwissADME DEREK identified MAOBrelated related disorders lead-hopping

Resumen Objetivo: Adaptar y validar en el contexto sonorense la Escala para medir Actitudes hacia las Personas Transgénero en Estudiantes Universitarios (EATU) que mide la inclusión de personas trans en Instituciones de Educación Superior (IES). Diseño metodológico: Es un estudio cuantitativo, transversal y no experimental. De tres IES, participaron 860 personas seleccionadas con muestreo no probabilístico e intencional. Se aplicó una escala tipo Likert de 4 puntos que evalúa actitudes transincluyentes. La fiabilidad se obtuvo con alfa de Cronbach y omega de McDonald. Para la validez la muestra se dividió al azar en dos; en la submuestra 1 se llevó a cabo un Análisis Factorial Exploratorio (AFE) y en la submuestra 2 se probó el modelo resultante del AFE mediante un Modelo de Ecuaciones Estructurales (MEE). Resultados: El AFE arrojó una solución final de la EATU de 32 ítems agrupados en 3 dimensiones denominadas sensibilidad, convivencia y estigma cisexista, con valores de fiabilidad superiores a .90 y de cargas factoriales superiores a .36. El MEE generó un modelo con índices de bondad de ajuste en una solución final de 17 ítems y 3 dimensiones correlacionadas con coeficientes superiores a .46. Limitaciones de la investigación: La medición de actitudes de transinclusión en una sociedad donde se ha documentado que tal constructo está en desarrollo y el no recabar datos demográficos en la muestra sobre sus creencias religiosas. Hallazgos: Un instrumento de medida sobre actitudes transincluyentes para actores sociales clave interesados en la promoción de la inclusión de las personas trans, sus derechos humanos y la igualdad sustantiva.

Abstract Purpose: To adapt and validate in Sonora the scale to measure Attitudes towards Transgender People in University Students (EATU), which measures the inclusion of trans people in Higher Education Institutions (HEIS). Methodological design: Quantitative, cross-sectional and non-experimental study. 860 participants were selected among three HEIS, with non-probabilistic and intentional sampling. A 4-point Likert-type scale survey was applied that evaluates transinclusive attitudes. Reliability was obtained with Cronbach's alpha and McDonald's omega. For validity, the sample was randomly divided into two; In subsample 1, an Exploratory Factor Analysis (EFA) was carried out and in subsample 2, the model resulting from the EFA was tested using a Structural Equation Model (SEM). Results: The EFA yielded a final solution EATU of 32 items grouped into 3 dimensions called sensitivity, coexistence and cisexist stigma, with values that demonstrate validity and reliability. The SEM generated a model with indices of fitness in a final solution of 17 items and 3 correlated dimensions with acceptable coefficients. Research limitations: The measurement of transinclusion attitudes in a society where it has been documented that such construct is barely being developing, and the failure to collect demographic data on the sample about their religious beliefs. Findings: A measurement instrument on transinclusive attitudes for key social actors interested in promoting the inclusion of trans people, their human rights and substantive equality.

Glycerophospholipids (GP) are important lipids of direct relevance to health and disease, and in marine fish, they are often enriched in omega-3 polyunsaturated fatty acids (PUFA) due to marine microorganisms consumption. It has been speculated that the different diets and habitats to which Amazonian fish are exposed can be ascribed to different lipid compositions, differently than those that occur in marine fish. Here, the GP in Amazonian fish is investigated to achieve nutritional value. Using mass spectrometry and multivariate statistical analysis, we investigated the GP composition of muscles and livers from nine species of wild Amazonian fish. GP profiles mainly comprised a diversity of phosphatidylcholines and varied according to eating habits, the season of capture, and tissue metabolism. In this sense, our results may help in the future aquaculture as a potential source of lipid-based nutrient supplementation to supply food to eradicate global hunger. (GP disease omega3 omega 3 omega- PUFA (PUFA consumption compositions Here value analysis habits capture metabolism sense lipidbased based hunger

Abstract Objective Perform the validation and psychometric evaluation of the Brazilian-Portuguese translation of the Functional Outcome of Sleep Questionnaire 10 (FOSQ10). Materials and methods 182 patients (65 females 48.3 ± 14.4 years and 117 males 46.9 ± 12.4 years), were evaluated by sleep physicians suspected of having Obstructive Sleep Apnea, underwent polysomnography and completed the FOSQ-10 and the Epworth Sleepiness Scale. APA & NCME, 2014 was used to validate the data as the American Educational Research Association recommended. Results Quality indicators such as Bartlett's test of sphericity (χ2 = 1108.2; gL = 45; p = 0.000010) and KMO (0.83), and adherence measures, attest to the quality of the model. The indicators TLI (0.97), CFI (0.98), and RMSEA (0.04) fall within the expected values. Using the Eigenvalue > 1 technique, two factors explain 53% and 13.3% of the variances. In the Parallel Analysis technique, a single factor explained 59.4653% of the random variance, and the Unidimensionality indicators UniCo = 0.921, ECV = 0.822, and MIREAL = 0.253, were supported. Construct Validity: reliability coefficients Cronbach’s α = 0.87, McDonald’s ordinal Omega index 0.9, and the Composite Reliability 0.891 were satisfactory. Convergent validity There was a significant Spearman correlation between FOSQ-10 and the Epworth Sleepiness Scale (r = 0.364 [−0.487; −0.226]). Criterion validity Was not possible to differentiate the groups based on the severity of AHI using FOSQ-10P. Conclusions The Brazilian translation of FOSQ-10 is valid and reliable for identifying significant effects of excessive daytime sleepiness in patients with Obstructive Sleep Apnea. Level of evidence 2. BrazilianPortuguese Portuguese FOSQ10. FOSQ10 FOSQ . (FOSQ10) 18 65 (6 483 48 3 48. 144 14 4 14. 11 469 46 9 46. 124 12 12. years, , years) Apnea FOSQ-1 NCME 201 recommended Bartletts Bartlett s χ2 χ (χ 1108.2 11082 1108 2 45 0.000010 0000010 0 000010 0.83, 083 0.83 83 (0.83) measures model 0.97, 097 0.97 97 (0.97) 0.98, 098 0.98 98 (0.98) 0.04 004 04 (0.04 values technique 53 133 13 13.3 variances 594653 59 4653 59.4653 variance 0921 921 0.921 0822 822 0.822 0253 253 0.253 supported Validity Cronbachs Cronbach 087 87 0.87 McDonalds McDonald 09 0.9 0891 891 0.89 satisfactory r 0364 364 0.36 −0.487 0487 487 [−0.487 −0.226. 0226 −0.226 226 −0.226]) FOSQ10P. FOSQ10P FOSQP 10P. 10P P FOSQ-10P FOSQ1 (FOSQ10 6 ( FOSQ- 20 1108. 110 0.00001 000001 00001 08 0.8 8 (0.83 (0.97 (0.98 0.0 00 (0.0 5 13. 59465 465 59.465 092 92 0.92 082 82 0.82 025 25 0.25 0. 089 89 036 36 0.3 −0.48 048 [−0.48 022 −0.22 22 −0.226] (FOSQ1 0.0000 00000 0000 (0.8 (0.9 (0. 5946 59.46 02 0.2 03 −0.4 [−0.4 −0.2 (FOSQ 0.000 000 (0 594 59.4 −0. [−0. 0.00 59. −0 [−0 − [− [

Abstract Background The stress experienced by parents in fulfilling their parental role has consequences for couple dynamics, parent–child interactions, and the mental health of parents. However, studies on the psychometric properties of the PSI-SF, particularly among Latin American parents, are scarce. Therefore, this study aims to evaluate the psychometric properties of the Spanish version of the Parenting Stress Index-Short Form (PSI-SF). Methods The participants were Peruvian mothers and fathers with children in early childhood and primary education, with a mean age of 34.4 years (SD = 6.8). The sample was obtained in two phases: 130 participants for the Exploratory Factor Analysis (EFA) and 791 participants for the Confirmatory Factor Analysis (CFA). Results The study results show a modified three-factor structure of the PSI-SF scale, with adequate fit indices (GFI = .99, AGFI = .99, SRMR = .024, CFI = .98, TLI = .98, RMSEA = .074) and loadings above 0.40. Additionally, the three factors of the scale demonstrated high reliability, with Cronbach's alpha and McDonald's omega values for Parental Distress (α = .94; ω = .95), Parent–Child Dysfunctional Interaction (α = .97; ω = .97), and Difficult Child (α = .94; ω = .94). The scale was also found to be invariant with respect to gender. Conclusion In conclusion, the study results suggest that the modified PSI-SF has adequate psychometric properties and is invariant for assessing parental stress in Peruvian fathers and mothers with children in early childhood and primary education. dynamics parentchild parent child interactions However PSISF, PSISF PSI SF, SF scarce Therefore IndexShort Index Short PSISF. . (PSI-SF) education 344 34 4 34. SD 6.8. 68 6.8 6 8 6.8) phases 13 EFA (EFA 79 CFA. CFA (CFA) threefactor factor GFI 99 .99 024 .024 98 .98 .074 074 040 0 40 0.40 Additionally reliability Cronbachs Cronbach s McDonalds McDonald α .94 94 .95, 95 .95 , .95) ParentChild Parent .97 97 .97, .97) .94. .94) gender conclusion (PSI-SF 3 6. 1 7 (CFA 9 .9 02 .02 .07 07 04 0.4 .0 0.

Objective: Depression is a major public health problem. Many complementary and alternative medicine (CAM) interventions have been suggested as potential treatments. This umbrella review aimed to assess the efficacy and safety of CAM interventions for treating depression. Methods: We comprehensively searched for relevant systematic reviews and meta-analyses in the MEDLINE (via PubMed), EMBASE, Web of Science, and Cochrane Library databases. We assessed effectiveness (based on efficacy and changes in depression assessment scale scores) and safety (based on adverse events). Results: A total of 22 eligible articles were included. Yueju antidepressant and electro-acupuncture (EA) improved depression symptoms better than conventional antidepressants. In addition, omega-3 fatty acids (n-3PUFAs), exercise, manual acupuncture (MA), Hypericum mono-preparations, relaxation, and vitamin D showed superior efficacy to placebo and controls. Guipi decotion (GPD) as adjunctive therapy has higher efficacy than conventional antidepressants, and MA and Yueju have a better safety profile than conventional antidepressants. Conclusion: 10 CAMs can effectively improve the condition of patients with clinical depression. Objective problem (CAM treatments Methods metaanalyses meta analyses via PubMed, PubMed , PubMed) EMBASE Science databases based scores events. events . events) Results 2 included electroacupuncture electro EA (EA antidepressants addition omega3 omega 3 omega- n3PUFAs, n3PUFAs nPUFAs n 3PUFAs PUFAs (n-3PUFAs) exercise MA, (MA) monopreparations, monopreparations mono preparations, preparations mono-preparations relaxation controls GPD (GPD Conclusion 1 (n-3PUFAs (MA

Objective: To design and validate a Brazilian version of the Animal Empathy Scale, based on the existing Portuguese version. Methods: Content validity assessment was performed by expert judges, and the adapted scale was administered to a sample of 386 participants. Exploratory and confirmatory factor analyses were performed. Results: The bifactorial profile of the scale remained consistent, comprising Empathic Concern for Animals (Cronbach's alpha and McDonald's omega coefficients: 0.75) and Emotional Attachment with Animals (Cronbach's alpha and McDonald's omega coefficients: 0.79). Considering the One Health framework, collaborative, multidisciplinary, and intersectoral approaches are essential for achieving optimal health conditions for people, animals, and the environment given their intricate interconnections. Empathy plays a crucial role in promoting proximity between humans and animals, fostering positive connections that encourage biodiversity conservation. Conclusion: The 13 statements were retained, confirming the validity of the animal empathy scale for use in Brazil, and a Brazilian version of the Animal Empathy Scale was established. Objective Methods judges 38 participants Results consistent Cronbachs Cronbach s McDonalds McDonald coefficients 0.75 075 0 75 0.79. 079 0.79 . 79 0.79) framework collaborative multidisciplinary people animals interconnections conservation Conclusion 1 retained Brazil established 3 0.7 07 7 0.

Resumo O objetivo deste estudo foi desenvolver um instrumento capaz de medir o nível de incapacitação funcional causado por enxaqueca. Na primeira etapa, a partir de análise da literatura e entrevistas com oito pessoas diagnosticadas com enxaqueca, foram construídos 54 itens que descrevem prejuízos no funcionamento dos indivíduos quando passam por uma crise de enxaqueca. As análises semântica e de conteúdo resultaram na exclusão de 14 itens. Na segunda etapa, participaram 354 enxaquecosos. Foram investigadas a estrutura interna por análises fatoriais exploratórias, a fidedignidade por ômega de Mcdonald e estabelecida normatização inicial por percentis. O instrumento, nomeado como Escala de Incapacitação Funcional por Enxaqueca, ficou composto por 20 itens, divididos em três fatores: Limitação de atividades (9 itens, ω = 0,90), Impacto emocional (6 itens, ω = 0,87) e Impacto cognitivo (5 itens, ω = 0,90). Os resultados, ainda que iniciais, indicam que o instrumento é promissor no rastreio de sinais de incapacitação causada pela enxaqueca. enxaqueca etapa 5 1 35 enxaquecosos exploratórias percentis Enxaqueca 2 fatores 9 ( 0,90, 090 0,90 , 0 90 0,90) 6 0,87 087 87 0,90. . resultados iniciais 3 09 0,9 0,8 08 8 0,

Resumen El objetivo de este estudio fue desarrollar un instrumento capaz de medir el nivel de incapacidad funcional causada por la migraña. En la primera etapa, a través del análisis de la literatura y entrevistas con ocho personas diagnosticadas con migraña, se construyeron 54 ítems que describen los perjuicios en el funcionamiento de los individuos durante una crisis de migraña. Los análisis semántico y de contenido resultaron en la exclusión de 14 ítems. En la segunda etapa, participaron 354 individuos con migraña. Se investigó la estructura interna mediante análisis factoriales exploratorios, la confiabilidad mediante el índice omega de McDonald y se estableció la normalización inicial mediante percentiles. El instrumento, denominado Escala de Incapacidad Funcional por Migraña, quedó compuesto por 20 ítems, divididos en tres factores: Limitación de Actividades (9 ítems, ω = .90), Impacto Emocional (6 ítems, ω = .87) e Impacto Cognitivo (5 ítems, ω = .90). Aunque preliminares, los resultados sugieren que el instrumento es prometedor para la detección de signos de incapacidad causada por la migraña. migraña etapa 5 1 35 exploratorios percentiles Migraña 2 factores 9 ( .90, 90 .90 , .90) 6 .87 87 .90. . preliminares 3 .9 .8 8

Abstract This study aimed to develop an instrument capable of measuring the level of functional impairment caused by migraine. In the initial phase, based on literature analysis and interviews with eight individuals diagnosed with migraine, 54 items were constructed describing impairments in individuals’ functioning during a migraine episode. Semantic and content analyses led to the exclusion of 14 items. In the second phase, 354 migraineurs participated. The internal structure was investigated using exploratory factor analyses, reliability was assessed using McDonald’s omega, and initial standardization was established by percentiles. The instrument, named the Migraine Functional Impairment Scale, consisted of 20 items divided into three factors: Activity Limitation (9 items, ω = .90), Emotional Impact (6 items, ω = .87), and Cognitive Impact (5 items, ω = .90). Although preliminary, the results suggest promising potential for the instrument in screening for signs of migraine-related impairment. phase 5 episode 1 35 participated McDonalds McDonald s omega percentiles Scale 2 factors 9 ( .90, 90 .90 , .90) 6 .87, 87 .87 .87) .90. . preliminary migrainerelated related 3 .9 8 .8

RESUMO Objetivos: analisar as evidências de validade da estrutura interna do Questionário da Automedicação de Risco Focado no Letramento em Saúde. Métodos: estudo psicométrico, com 499 adultos. Avaliou-se a estrutura interna com análise fatorial exploratória e confirmatória para comprovar o ajuste. A consistência interna foi medida pela fidedignidade composta e pelo coeficiente ômega de McDonald (ω). Resultados: os parâmetros revelaram modelo de 35 itens distribuídos em quatro fatores, explicando 56% da variância total, com cargas fatoriais variando de 0,31 a 0,85 e comunalidades adequadas. Os indicadores precisão (0,79<ORION<0,98), representatividade (0,89<FDI<0,99), sensibilidade (1,92<SR<7,07), esperança do fator (88,3%<EPTD<97,9%), replicabilidade (0,82<H-Latente<H-observado<0,87) e confiabilidade (ω=0,87) foram adequados. A fidedignidade composta variou de 0,840 a 0,910. Além disso, alcançou-se bom ajuste do modelo (TLI = 0,99; CFI = 0,99; GFI = 0,95; RMSEA = 0,02; e RMSR = 0,05). Conclusões: obteve-se instrumento com boas evidências de validade de estrutura para mensuração da automedicação. Objetivos Saúde Métodos psicométrico 49 adultos Avaliouse Avaliou se ω. ω . (ω) Resultados 3 fatores 56 total 031 0 31 0,3 085 85 0,8 adequadas 0,79<ORION<0,98, 079ORION098 ORION 0,79<ORION<0,98 , 79 98 (0,79<ORION<0,98) 0,89<FDI<0,99, 089FDI099 FDI 0,89<FDI<0,99 89 99 (0,89<FDI<0,99) 1,92<SR<7,07, 192SR707 SR 1,92<SR<7,07 1 92 7 07 (1,92<SR<7,07) 88,3%<EPTD<97,9%, 883EPTD979 EPTD 88,3%<EPTD<97,9% 88 97 9 (88,3%<EPTD<97,9%) 0,82<HLatente<Hobservado<0,87 082HLatenteHobservado087 HLatenteHobservado 0,82<H Latente<H observado<0,87 82 H Latente observado 87 (0,82<H-Latente<H-observado<0,87 ω=0,87 ω087 (ω=0,87 adequados 0840 840 0,84 0910 910 0,910 disso alcançouse alcançou TLI 0,99 099 0,95 095 95 0,02 002 02 0,05. 005 0,05 05 0,05) Conclusões obtevese obteve automedicação 4 (ω 5 03 0, 08 8 079ORION09 0,79<ORION<0,9 (0,79<ORION<0,98 089FDI09 0,89<FDI<0,9 (0,89<FDI<0,99 192SR70 1,92<SR<7,0 (1,92<SR<7,07 883EPTD97 88,3%<EPTD<97,9 (88,3%<EPTD<97,9% HLatente Hobservado 0,82<HLatente<Hobservado<0,8 082HLatenteHobservado08 082H LatenteH observado087 observado<0,8 (0,82<H-Latente<H-observado<0,8 ω=0,8 ω08 (ω=0,8 084 84 091 91 0,91 0,9 09 0,0 00 079ORION0 0,79<ORION<0, (0,79<ORION<0,9 089FDI0 0,89<FDI<0, (0,89<FDI<0,9 192SR7 1,92<SR<7, (1,92<SR<7,0 883EPTD9 88,3%<EPTD<97, (88,3%<EPTD<97,9 0,82<HLatente<Hobservado<0, 082HLatenteHobservado0 observado08 observado<0, (0,82<H-Latente<H-observado<0, ω=0, ω0 (ω=0, 079ORION 0,79<ORION<0 (0,79<ORION<0, 089FDI 0,89<FDI<0 (0,89<FDI<0, 192SR 1,92<SR<7 (1,92<SR<7, 883EPTD 88,3%<EPTD<97 (88,3%<EPTD<97, 0,82<HLatente<Hobservado<0 082HLatenteHobservado observado0 observado<0 (0,82<H-Latente<H-observado<0 ω=0 (ω=0 0,79<ORION< (0,79<ORION<0 0,89<FDI< (0,89<FDI<0 1,92<SR< (1,92<SR<7 88,3%<EPTD<9 (88,3%<EPTD<97 0,82<HLatente<Hobservado< observado< (0,82<H-Latente<H-observado< ω= (ω= 0,79<ORION (0,79<ORION< 0,89<FDI (0,89<FDI< 1,92<SR (1,92<SR< 88,3%<EPTD< (88,3%<EPTD<9 0,82<HLatente<Hobservado (0,82<H-Latente<H-observado (0,79<ORION (0,89<FDI (1,92<SR 88,3%<EPTD (88,3%<EPTD< (88,3%<EPTD

RESUMEN Objetivos: analizar la evidencia de validez de la estructura interna del Cuestionario de Automedicación de Riesgos Enfocado a la Alfabetización en Salud. Métodos: estudio psicométrico, con 499 adultos. La estructura interna fue evaluada con análisis factorial exploratorio y confirmatorio para comprobar el ajuste. La consistencia interna se midió mediante la confiabilidad compuesta y el coeficiente omega de McDonald (ω). Resultados: los parámetros revelaron un modelo de 35 ítems distribuidos en cuatro factores, explicando el 56% de la varianza total, con cargas factoriales que oscilaron entre 0,31 y 0,85 y comunalidades adecuadas. Los indicadores precisión (0,79<ORION<0,98), representatividad (0,89<FDI<0,99), sensibilidad (1,92<SR<7,07), factor esperanza (88,3%< EPTD<97,9%), replicabilidad (0,82<H-Latente<H -observado<0,87) y la confiabilidad (ω=0,87) fueron adecuadas. La confiabilidad compuesta osciló entre 0,840 y 0,910. Además, se logró un buen ajuste del modelo (TLI = 0,99; CFI = 0,99; GFI = 0,95; RMSEA = 0,02 y RMSR = 0,05). Conclusiones: se obtuvo un instrumento con buena evidencia de validez estructural para medir la automedicación. Objetivos Salud Métodos psicométrico 49 adultos ω. ω . (ω) Resultados 3 factores 56 total 031 0 31 0,3 085 85 0,8 adecuadas 0,79<ORION<0,98, 079ORION098 ORION 0,79<ORION<0,98 , 79 98 (0,79<ORION<0,98) 0,89<FDI<0,99, 089FDI099 FDI 0,89<FDI<0,99 89 99 (0,89<FDI<0,99) 1,92<SR<7,07, 192SR707 SR 1,92<SR<7,07 1 92 7 07 (1,92<SR<7,07) 88,3%< 883 88 (88,3% EPTD<97,9%, EPTD979 EPTD EPTD<97,9% 97 9 EPTD<97,9%) 0,82<HLatente<H 082HLatenteH HLatenteH 0,82<H Latente<H 82 H Latente observado<0,87 observado087 observado 87 -observado<0,87 ω=0,87 ω087 (ω=0,87 0840 840 0,84 0910 910 0,910 Además TLI 0,99 099 0,95 095 95 002 02 0,0 0,05. 005 0,05 05 0,05) Conclusiones automedicación 4 (ω 5 03 0, 08 8 079ORION09 0,79<ORION<0,9 (0,79<ORION<0,98 089FDI09 0,89<FDI<0,9 (0,89<FDI<0,99 192SR70 1,92<SR<7,0 (1,92<SR<7,07 88,3% (88,3 EPTD97 EPTD<97,9 HLatente 082H LatenteH observado<0,8 observado08 -observado<0,8 ω=0,8 ω08 (ω=0,8 084 84 091 91 0,91 0,9 09 00 079ORION0 0,79<ORION<0, (0,79<ORION<0,9 089FDI0 0,89<FDI<0, (0,89<FDI<0,9 192SR7 1,92<SR<7, (1,92<SR<7,0 88,3 (88, EPTD9 EPTD<97, observado<0, observado0 -observado<0, ω=0, ω0 (ω=0, 079ORION 0,79<ORION<0 (0,79<ORION<0, 089FDI 0,89<FDI<0 (0,89<FDI<0, 192SR 1,92<SR<7 (1,92<SR<7, 88, (88 EPTD<97 observado<0 -observado<0 ω=0 (ω=0 0,79<ORION< (0,79<ORION<0 0,89<FDI< (0,89<FDI<0 1,92<SR< (1,92<SR<7 (8 EPTD<9 observado< -observado< ω= (ω= 0,79<ORION (0,79<ORION< 0,89<FDI (0,89<FDI< 1,92<SR (1,92<SR< ( EPTD< -observado (0,79<ORION (0,89<FDI (1,92<SR

ABSTRACT Objectives: to analyze the validity evidence of the internal structure of the Risk Self-Medication Questionnaire Focused on Health Literacy. Methods: a psychometric study with 499 adults. The internal structure was assessed with exploratory and confirmatory factor analysis to prove the adjustment. Internal consistency was measured by composite reliability and McDonald’s omega coefficient (ω). Results: the parameters revealed a model of 35 items distributed across four factors, explaining 56% of the total variance, with factor loadings ranging from 0.31 to 0.85 and adequate communalities. Accuracy (0.79<ORION<0.98), representativeness (0.89<FDI<0.99), sensitivity (1.92<SR<7.07), factor hope (88.3%< EPTD<97.9%), replicability (0.82<H-Latent<H-observed<0.87) and reliability (ω=0.87) were adequate. The composite reliability ranged from 0.840 to 0.910. Furthermore, good model fit was achieved (TLI = 0.99; CFI = 0.99; GFI = 0.95; RMSEA = 0.02 and RMSR = 0.05). Conclusions: an instrument was obtained with good evidence of structural validity for measuring self-medication. Objectives SelfMedication Self Medication Literacy Methods 49 adults adjustment McDonalds McDonald s ω. ω . (ω) Results 3 factors 56 variance 031 0 31 0.3 085 85 0.8 communalities 0.79<ORION<0.98, 079ORION098 ORION 0.79<ORION<0.98 , 79 98 (0.79<ORION<0.98) 0.89<FDI<0.99, 089FDI099 FDI 0.89<FDI<0.99 89 99 (0.89<FDI<0.99) 1.92<SR<7.07, 192SR707 SR 1.92<SR<7.07 1 92 7 07 (1.92<SR<7.07) 88.3%< 883 88 (88.3% EPTD<97.9%, EPTD979 EPTD EPTD<97.9% 97 9 EPTD<97.9%) 0.82<HLatent<Hobserved<0.87 082HLatentHobserved087 HLatentHobserved 0.82<H Latent<H observed<0.87 82 H Latent observed 87 (0.82<H-Latent<H-observed<0.87 ω=0.87 ω087 (ω=0.87 0840 840 0.84 0910 910 0.910 Furthermore TLI 0.99 099 0.95 095 95 002 02 0.0 0.05. 005 0.05 05 0.05) Conclusions selfmedication. selfmedication self medication. medication self-medication 4 (ω 5 03 0. 08 8 079ORION09 0.79<ORION<0.9 (0.79<ORION<0.98 089FDI09 0.89<FDI<0.9 (0.89<FDI<0.99 192SR70 1.92<SR<7.0 (1.92<SR<7.07 88.3% (88.3 EPTD97 EPTD<97.9 HLatent Hobserved 0.82<HLatent<Hobserved<0.8 082HLatentHobserved08 082H LatentH observed087 observed<0.8 (0.82<H-Latent<H-observed<0.8 ω=0.8 ω08 (ω=0.8 084 84 091 91 0.91 0.9 09 00 079ORION0 0.79<ORION<0. (0.79<ORION<0.9 089FDI0 0.89<FDI<0. (0.89<FDI<0.9 192SR7 1.92<SR<7. (1.92<SR<7.0 88.3 (88. EPTD9 EPTD<97. 0.82<HLatent<Hobserved<0. 082HLatentHobserved0 observed08 observed<0. (0.82<H-Latent<H-observed<0. ω=0. ω0 (ω=0. 079ORION 0.79<ORION<0 (0.79<ORION<0. 089FDI 0.89<FDI<0 (0.89<FDI<0. 192SR 1.92<SR<7 (1.92<SR<7. 88. (88 EPTD<97 0.82<HLatent<Hobserved<0 082HLatentHobserved observed0 observed<0 (0.82<H-Latent<H-observed<0 ω=0 (ω=0 0.79<ORION< (0.79<ORION<0 0.89<FDI< (0.89<FDI<0 1.92<SR< (1.92<SR<7 (8 EPTD<9 0.82<HLatent<Hobserved< observed< (0.82<H-Latent<H-observed< ω= (ω= 0.79<ORION (0.79<ORION< 0.89<FDI (0.89<FDI< 1.92<SR (1.92<SR< ( EPTD< 0.82<HLatent<Hobserved (0.82<H-Latent<H-observed (0.79<ORION (0.89<FDI (1.92<SR

RESUMO Objetivos: avaliar o construto do University Student Depression Inventory, versão brasileira (USDI-BR). Métodos: estudo metodológico, realizado com uma amostra probabilística bola de neve constituída de 334 estudantes de graduação e pós-graduação. Foram realizadas a análise fatorial confirmatória, a confiabilidade pelo coeficiente de ômega de McDonald e o alfa de Cronbach. A análise por componentes principais foi realizada utilizando a rotação ortogonal varimax e a rotação oblíqua oblimin, por meio dos critérios de Kaiser-Meyer-Olkin, teste de esfericidade de Bartlett e scree plot. Resultados: o USDI-BR apresentou consistência interna dos itens de ω = 0,95 e permaneceu com 30 itens, com acréscimo de 1 fator (Desejo de morrer e retraimento social), totalizando 4 fatores. Conclusões: o USDI-BR possui evidências que remetem à sua validade e também à sua consistência interna, merecendo que novos estudos sejam realizados visando ampliar as evidências de suas propriedades psicométricas. Objetivos Inventory USDIBR. USDIBR USDI BR . (USDI-BR) Métodos metodológico 33 pósgraduação. pósgraduação pós graduação. pós-graduação confirmatória Cronbach oblimin KaiserMeyerOlkin, KaiserMeyerOlkin Kaiser Meyer Olkin, Olkin Kaiser-Meyer-Olkin plot Resultados 095 0 95 0,9 3 Desejo social, social , social) fatores Conclusões psicométricas (USDI-BR 09 9 0,

RESUMEN Objetivos: evaluar el constructo del University Student Depression Inventory, versión brasileña (USDI-BR). Métodos: estudio metodológico, realizado con una muestra probabilística en bola de nieve compuesta por 334 estudiantes de pregrado y posgrado. Se realizaron análisis factoriales confirmatorios, confiabilidad mediante el coeficiente omega de McDonald y alfa de Cronbach. El análisis de componentes principales se realizó mediante rotación ortogonal varimax y rotación oblicua oblimin, utilizando los criterios de Kaiser-Meyer-Olkin, la prueba de esfericidad de Bartlett y scree plot. Resultados: el USDI-BR presentó una consistencia interna de ítems de ω = 0,95 y quedó con 30 ítems, con la adición de 1 factor (Deseo de muerte y alejamiento social), totalizando 4 factores. Conclusiones: el USDI-BR tiene evidencias que apuntan a su validez y también a su consistencia interna, ameritando que se realicen nuevos estudios para ampliar la evidencia de sus propiedades psicométricas. Objetivos Inventory USDIBR. USDIBR USDI BR . (USDI-BR) Métodos metodológico 33 posgrado confirmatorios Cronbach oblimin KaiserMeyerOlkin, KaiserMeyerOlkin Kaiser Meyer Olkin, Olkin Kaiser-Meyer-Olkin plot Resultados 095 0 95 0,9 3 Deseo social, social , social) factores Conclusiones psicométricas (USDI-BR 09 9 0,

ABSTRACT Objectives: to assess the University Student Depression Inventory, Brazilian version (USDI-BR), construct. Methods: a methodological study carried out with a snowball probabilistic sample, consisting of 334 undergraduate and graduate students. Confirmatory factor analysis, reliability using McDonald’s omega coefficient and Cronbach’s alpha were performed. Principal component analysis was performed using the varimax rotation and oblimin rotation, using the Kaiser-Meyer-Olkin criteria, Bartlett’s test of sphericity and scree plot. Results: the USDI-BR presented an internal consistency of items of ω = 0.95 and remained with 30 items, with the addition of 1 factor (Death wish and social withdrawal), totaling 4 factors. Conclusions: the USDI-BR has evidence that points to its validity and also its internal consistency, deserving that new studies be carried out to expand the evidence of its psychometric properties. Objectives Inventory USDIBR, USDIBR USDI BR , (USDI-BR) construct Methods sample 33 students McDonalds McDonald s Cronbachs Cronbach KaiserMeyerOlkin Kaiser Meyer Olkin criteria Bartletts Bartlett plot Results 095 0 95 0.9 3 Death withdrawal, withdrawal withdrawal) factors Conclusions properties (USDI-BR 09 9 0.

RESUMO O ácido linoleico conjugado (CLA) compreende o grupo de isômeros posicionais e geométricos do ácido linoleico. Na dieta de matrizes, aumenta a proporção de ácidos graxos saturados dos ovos e pode ser uma importante ferramenta para o estudo dos efeitos da suplementação materna de CLA sobre o metabolismo lipídico da progênie. Objetivou-se avaliar o efeito da inclusão de CLA na dieta de matrizes de frango de corte sobre o perfil de ácidos graxos da gema, a qualidade dos ovos e a incubação. Dois lotes comerciais de matrizes Cobb500®, com 58 semanas de idade, foram suplementados com 0% ou 0,025% de CLA (trans-10, cis-12). Após 26 dias, 300 ovos por tratamento foram coletados, dois quais 30 foram utilizados para as análises de qualidade e perfil de ácidos graxos da gema, enquanto os ovos restantes foram submetidos à incubação. A qualidade das aves foi avaliada à eclosão, e o peso e conteúdo do saco vitelínico residual foram avaliados à eclosão. Ovos não eclodidos foram submetidos a análise residual. A suplementação das matrizes não influenciou os parâmetros de incubação e peso dos pintos à eclosão. Contudo, modificou o perfil de ácidos graxos da gema e do saco vitelínico, levando ao acúmulo de CLA no saco vitelínico após a eclosão. Conclui-se que a suplementação de 0,025% de CLA na dieta de matrizes não altera parâmetros de incubação e o peso da progênie à eclosão, mas modifica os perfis de ômega-6 e ácidos palmitoleico, linoleico e araquidônico tanto na gema quando no saco vitelínico residual. (CLA Objetivouse Objetivou se Cobb500 Cobb Cobb500® 5 idade 0 0025 025 0,025 trans10, trans10 trans 10, 10 (trans-10 cis12. cis12 cis 12 . cis-12) 2 dias coletados 3 eclosão Contudo Concluise Conclui ômega6 ômega 6 ômega- palmitoleico Cobb50 002 02 0,02 trans1 1 (trans-1 cis1 cis-12 Cobb5 00 0,0 (trans- cis-1 0, (trans cis-

ABSTRACT Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid. Hens fed a diet supplemented with CLA exhibit increased levels of saturated fatty acids, which may influence the quality characteristics of eggs and the offspring lipid metabolism. The present study, aimed to evaluate the effect of the dietary inclusion of CLA for broiler breeders on the residual yolk sac fatty acid profile, egg quality, and hatchability. Two 58-week-old Cobb500® broiler breeder commercial flocks were fed diets supplemented with 0% or 0.025% CLA (trans-10, cis-12). After 26 days, 300 eggs from each treatment group were collected, and among these eggs, 30 were subjected to egg quality assessment and egg yolk fatty acid profile analysis. The remaining 270 eggs were subjected to incubation analysis. The quality of the chicks was evaluated at hatch. The residual yolk sac content and weight at hatch were also evaluated. Unhatched eggs were subjected to residual analysis. The supplementation of the breeders’ diet with 0.025% CLA did not influence the incubation parameters and the weight of the chicks at hatch. However, the egg yolk and residual yolk sac fatty acid profile were altered and CLA accumulation was increased in the residual yolk sac at hatch in this treatment group. In conclusion, CLA supplementation in the diet of breeders did not influence the incubation parameters and the weight of the chicks, although it did alter the profiles of omega-6, palmitoleic, linoleic, and arachidonic acids in both egg yolk and residual yolk sac. (CLA metabolism study hatchability 58weekold weekold 58 week old Cobb500 Cobb 0 0025 025 0.025 trans10, trans10 trans 10, 10 (trans-10 cis12. cis12 cis 12 . cis-12) 2 days collected 3 analysis 27 However conclusion omega6, omega6 omega 6, 6 omega-6 palmitoleic 5 Cobb50 002 02 0.02 trans1 1 (trans-1 cis1 cis-12 omega- Cobb5 00 0.0 (trans- cis-1 0. (trans cis-

SUMMARY OBJECTIVE: The aim of this study was to assess the dietary pattern of healthy adult and adolescent women, pregnant and non-pregnant, and relate this profile to clinical and laboratory characteristics. METHODS: A prospective cohort study was carried out with 40 women who met the selection criteria: 10 non-pregnant adults, 10 pregnant adults, 10 non-pregnant adolescents, and 10 pregnant adolescents. Dietary data were collected using a registration form, a 24-h recall, and a food frequency questionnaire. Serum levels of interleukin 6 and tumor necrosis factor α were determined by capture ELISA. RESULTS: The majority of women were married (22.5%), had completed high school (57.5%), and were white (47.5%). Overall, only one (10%) pregnant adult reported smoking. Dietary supplement use was reported by eight (80%) pregnant adults, four (40%) pregnant adolescents, two (20%) non-pregnant adolescents, and no non-pregnant adults. Pregnant adolescents had a higher intake of omega-3 when compared to pregnant adults and non-pregnant adults (p=0.01 and 0.02, respectively). Pregnant adolescents consumed less minimally processed foods than pregnant adults, non-pregnant adults, and non-pregnant adolescents (p=0.008, 0.019, and 0.024, respectively). Serum levels of tumor necrosis factor α and interleukin 6 did not show statistical differences among the four groups (p=0.229 and 0.440, respectively). CONCLUSIONS: The dietary patterns of healthy adult and adolescent women, whether pregnant or not, were similar, with pregnant adolescents having a higher intake of omega-3. Pregnant adolescents ate less in natura (minimally processed) food than all the other women. OBJECTIVE nonpregnant, nonpregnant non pregnant, characteristics METHODS 4 criteria 1 form 24h h 24 recall questionnaire ELISA RESULTS 22.5%, 225 22.5% , 22 5 (22.5%) 57.5%, 575 57.5% 57 (57.5%) 47.5%. 475 47.5% . 47 (47.5%) Overall 10% (10% smoking 80% 80 (80% 40% (40% 20% 20 (20% omega3 omega 3 omega- p=0.01 p001 p 0 01 (p=0.0 002 02 0.02 respectively. respectively respectively) p=0.008, p0008 008 (p=0.008 0019 019 0.019 0024 024 0.024 p=0.229 p0229 229 (p=0.22 0440 440 0.440 CONCLUSIONS similar omega3. 3. 2 22.5 (22.5% 57.5 (57.5% 47.5 (47.5% (10 8 (80 (40 (20 p=0.0 p00 (p=0. 00 0.0 p=0.008 p000 (p=0.00 001 0.01 p=0.22 p022 (p=0.2 044 44 0.44 22. (22.5 57. (57.5 47. (47.5 (1 (8 (4 (2 p=0. p0 (p=0 0. p=0.00 p=0.2 p02 04 0.4 (22. (57. (47. ( p=0 (p= (22 (57 (47 p= (p (5

Resumo Objetivo O presente estudo teve como objetivo adaptar o Questionário de Sintomas de Ansiedade e analisar suas propriedades psicométricas para a população brasileira. Método A adaptação foi realizada em seis etapas: tradução, síntese, retrotradução, análise de especialistas, avaliação da população alvo e estudo piloto, foram entrevistados 441 adultos (M = 35,36; DP = 11,08 anos): 301 saudáveis, 105 com ansiedade e 35 com depressão. Resultados Os resultados do Questionário de Sintomas de Ansiedade demonstraram evidências de validade de conteúdo, alta consistência interna (alfa de Cronbach = 0,975 e ômega de McDonald = 0,976), evidências de validade de critério ao diferenciar grupos com e sem ansiedade (F(2,438) = 22,647; p = < 0,01 ), validade convergente com a entrevista estruturada do DSM-5 (ρ = 0,70 e p < 0,01) e com o escore de ansiedade (ρ = 0,62 e p < 0,01), depressão (ρ = 0,64 e p < 0,01) e estresse (ρ = 0,70 e p < 0,01) de outro instrumento. Conclusão O Questionário de Sintomas de Ansiedade é válido e confiável para ser aplicado por profissionais da saúde na população brasileira. brasileira etapas tradução síntese retrotradução especialistas piloto 44 M 35,36 3536 36 1108 11 08 11,0 anos anos) 30 saudáveis 10 3 conteúdo alfa 0975 0 975 0,97 0,976, 0976 0,976 , 976 0,976) F2,438 F2438 F 2,438 2 438 (F(2,438 22,647 22647 22 647 001 01 0,0 ) DSM5 DSM 5 DSM- ρ 070 70 0,7 062 62 0,6 0,01, 064 64 instrumento 4 35,3 353 110 1 11, 097 97 0,9 F2 F2,43 F243 2438 2,43 43 (F(2,43 22,64 2264 00 0, 07 7 06 6 35, 09 9 F2,4 F24 243 2,4 (F(2,4 22,6 226 F2, 24 2, (F(2, 22, (F(2 (F( (F

Abstract Objective The present study aimed to adapt the Anxiety Symptoms Questionnaire and analyze its psychometric properties for the Brazilian population. Method The adaptation was conducted in six stages: translation, synthesis, back translation, expert analysis, evaluation by the target population, and a pilot study. A total of 441 adults (M = 35.36; SD = 11.08 years) were interviewed, with 301 classified as healthy, 105 as having anxiety, and 35 as having depression. Results The Anxiety Symptoms Questionnaire results demonstrated evidence of content validity, exhibiting high internal consistency (Cronbach’s alpha = 0.975 and McDonald’s omega = 0.976). Moreover, the questionnaire showed evidence of criterion validity by effectively distinguishing between groups with and without anxiety (F(2.438) = 22.647; p < 0.01), as well as convergent validity with the structured clinical interview for DSM-5 (ρ = 0.70, p < 0.01), and correlations with anxiety (ρ = 0.62, p < 0.01), depression (ρ = 0.64, p < 0.01), and stress (ρ = 0.70, p < 0.01) scores from another instrument. Conclusion The Anxiety Symptoms Questionnaire is valid and reliable for use by healthcare professionals in the Brazilian population. population stages translation synthesis analysis 44 M 35.36 3536 36 1108 11 08 11.0 years interviewed 30 healthy 10 3 Cronbachs Cronbach s 0975 0 975 0.97 McDonalds McDonald 0.976. 0976 0.976 . 976 0.976) Moreover F2.438 F2438 F 2.438 2 438 (F(2.438 22.647 22647 22 647 0.01, 001 0.01 , 01 DSM5 DSM 5 DSM- ρ 070 70 0.70 062 62 0.62 064 64 0.64 instrument 4 35.3 353 110 1 11. 097 97 0.9 F2 F2.43 F243 2438 2.43 43 (F(2.43 22.64 2264 00 0.0 07 7 0.7 06 6 0.6 35. 09 9 0. F2.4 F24 243 2.4 (F(2.4 22.6 226 F2. 24 2. (F(2. 22. (F(2 (F( (F

ABSTRACT Objective: Inflammation causes the progressive destruction of the supporting tissues around teeth in patients with periodontitis. Therefore, this study aimed to investigate the immunological effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as adjunctive therapy in patients with periodontal disease and identify potential biomarkers for the disease. Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to investigate the impact of omega-3 therapy with or without acetylsalicylic acid on the immunological parameters of periodontal treatment. Eligible studies included those conducted on patients with normoglycemia and diabetes, published after 2002 in English, and containing relevant keywords. The exclusion criteria included pre-2002 publications, literature reviews, animal studies, and articles without immunological analysis. This review involved careful study selection by two double-blind researchers using the Rayyan software, with data extraction and analysis performed by the third and fourth reviewers. Results: Seven randomized clinical trials that compared control/placebo and n-3 PUFA groups or the follow-ups of the n-3 PUFA groups were included. The concentration of inflammatory cytokines was reduced following dietary supplementation with n-3 PUFA in the reviewed studies. Specifically, IL-1β, TNF-α, IL-6, and RANKL levels were reduced after dietary supplementation with n-3 PUFA as an adjunctive therapy for periodontitis. Changes in inflammatory outcomes were associated with the clinical benefits of periodontitis. However, significant divergence in the evaluated inflammatory markers, samples, and methods impairs direct comparisons and quantitative analyses in the available literature. Conclusion: This study highlights the need for clinical trials to advance our understanding and assessment of inflammatory outcomes in patients with periodontitis. Objective periodontitis Therefore omega3 omega 3 omega- n3 n (n- PUFAs Methods MetaAnalyses Meta Analyses treatment diabetes 200 English keywords pre2002 pre pre-200 publications reviews doubleblind double blind software reviewers Results controlplacebo control placebo n- followups follow ups Specifically IL1β, IL1β ILβ IL 1β, 1β β IL-1β TNFα, TNFα TNF α, α TNF-α IL6, IL6 6, 6 IL-6 However markers samples Conclusion (n 20 pre200 pre-20 IL- 2 pre20 pre-2 pre2 pre-