The history of the discovery, use, and development of dyes is closely linked to the history of humanity itself. Among the first records of human civilization are cave paintings made from, e.g., fruits, plants, minerals, and insects. Over the centuries, using different techniques, colors have been given to all types of materials and products, from clothing to food. The chemicals responsible for colors are dyes - a vast collection of molecules of the most varied compositions, but which have in common the absorption of light within the visible window of the electromagnetic spectrum. This article aims not only to review the properties of some classes of natural dyes, their origins, and their applications but also to describe the various computational chemistry methods involved in designing new bio-inspired molecules. discovery use itself eg e g e.g. fruits plants minerals insects centuries techniques products food compositions spectrum origins bioinspired bio inspired e.g

Phosphate species can affect aquatic ecosystems, as excess of this nutrient can cause eutrophication, generating environmental impacts. Lamellar double hydroxides have shown promise in removing phosphate at low concentrations (10-50 mg L 1). In this context, lamellar double hydroxides were synthesized interspersed with nitrates and humic substances, searching for a new product that favors phosphorus adsorption. X-ray diffraction showed the presence of characteristic peaks of lamellar double hydroxides and thermogravimetric analysis showed the decomposition behavior of lamellar structure. The adsorption capacity occurred quickly (< 30 min), being more efficient for lamellar double hydroxides with NO3. The maximum adsorption capacity showed results of 35.03 and 44.20 mg g 1 for lamellar double hydroxides with humic substances and lamellar double hydroxides with NO3, respectively. The complexation capacity showed that pH directly influences complexation, being greater for lamellar double hydroxides with humic substances at pH 6.5. Thus, nanostructured materials with humic substances are promising for use in contaminant remediation and adsorption can be a fast and efficient technique for use in soil and water. ecosystems eutrophication impacts 1050 10 50 (10-5 1. . 1) context Xray X ray structure < ( 3 min, min , min) NO3 NO 3503 35 03 35.0 4420 44 20 44.2 respectively 65 6 5 6.5 Thus water 105 (10- 350 0 35. 442 4 2 44. 6. (10 (1

A series of novel thieno[2,3-d]pyrimidine derivatives were designed, synthesized and evaluated for their biological ability. 2-Amino-4,7-dihydro-5H-thieno[2,3-d]pyrano-3-cyanonitrile was synthesized by Gewald reaction using pyranone as substrate, malonitrile and sulfur powder as raw materials and triethylamine as base at room temperature. Subsequent amination with N,N-dimethylformamide dimethyl acetal (DMF-DMA) gave N'-(3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-N,N-dimethylmethanimidamide. In this article, the 23 thieno[2,3-d] pyrimidines were obtained by Dimroth rearrangement condensation with different anilines, 16 of them being new compounds. Meanwhile, all compounds were assessed for breast cancer MDA-MB-231 cell line bioactivity with paclitaxel (PTX) as the positive control, and all compounds in the series showed inhibitory effects on breast cancer cell MDA-MB-231. The IC50 of compound l against MDA-MB-231 is 27.6 μM, which is similar to that of PTX with an IC50 of 29.3 μM. This means that compound l exhibits comparable inhibitory activity to PTX in MDA-MB-231 cells and may be considered as a potential anti-MDA-MB-231 inhibitor. thieno2,3dpyrimidine thieno23dpyrimidine thienodpyrimidine thieno 2,3 d pyrimidine 2 3 designed ability 2Amino4,7dihydro5Hthieno2,3dpyrano3cyanonitrile 2Amino47dihydro5Hthieno23dpyrano3cyanonitrile AminodihydroHthienodpyranocyanonitrile Amino 4,7 dihydro 5H pyrano cyanonitrile 4 7 H substrate temperature N,Ndimethylformamide NNdimethylformamide N,N dimethylformamide N DMFDMA DMF DMA (DMF-DMA N3cyano4,7dihydro5Hthieno2,3cpyran2ylN,Ndimethylmethanimidamide. N3cyano47dihydro5Hthieno23cpyran2ylNNdimethylmethanimidamide NcyanodihydroHthienocpyranylNNdimethylmethanimidamide cyano c pyran yl dimethylmethanimidamide. dimethylmethanimidamide N'-(3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-N,N-dimethylmethanimidamide article thieno2,3d thieno23d thienod thieno[2,3-d anilines 1 Meanwhile MDAMB231 MDAMB MDA MB 231 MDA-MB-23 (PTX control MDAMB231. 231. IC IC5 276 27 6 27. μM 293 29 29. antiMDAMB231 antiMDAMB anti anti-MDA-MB-23 inhibitor thieno2 3dpyrimidine dpyrimidine 2, 2Amino4 7dihydro5Hthieno2 3dpyrano3cyanonitrile Hthieno dpyrano 47 4, Ndimethylformamide NN N3cyano4 3cpyran2ylN Ndimethylmethanimidamide cpyran ylN N3cyano4,7dihydro5Hthieno2,3cpyran2ylN,Ndimethylmethanimidamide ylNNdimethylmethanimidamide 3d MDAMB23 MDA-MB-2 antiMDAMB23 anti-MDA-MB-2 2Amino dihydroHthieno 7dihydro5Hthieno dpyranocyanonitrile Ncyano N3cyano cpyranylN MDAMB2 MDA-MB- antiMDAMB2 anti-MDA-MB- MDA-MB anti-MDA-MB

Abstract The article presents the conception of an acoustic project for a new opera house, called “O Guarani”, to be implemented at the federal capital, Brasília, with about 1000 seats. The main focus of the article is the acoustic conditioning of the opera house. Initially, the basic assumptions from the acoustical point of view that an opera house demands are discussed. The main constraints, such as reverberation time, must take into account both music and speech which is a typical characteristic for a room of this kind. Once the architectural concept and the materials to be used have been defined, a computational simulation is carried out, aiming to determine acoustic quality parameters, such as T20, C80 and D50, for receivers distributed in the audience. These parameters proved to be satisfactory for the intended use of the proposed theater. An auralization is then conducted. This is prepared for an aria of the opera “Don Giovanni”, by Mozart, from an anechoic recording of a soprano, interpreting D. Elvira, and ten accompanying musical instruments. The result of the auralization - available at a link - seems to show the good sound quality obtained by the proposed acoustic project. O Guarani, Guarani , Guarani” capital Brasília 100 seats Initially discussed constraints time kind defined out T20 T C C8 D50 D audience theater conducted Don Giovanni, Giovanni Giovanni” Mozart soprano Elvira instruments 10 T2 D5 1

Resumo O artigo apresenta a concepção de um projeto acústico para uma nova casa de ópera, denominada “O Guarani”, a ser implantada na capital federal, Brasília, com cerca de 1000 assentos. O foco principal do artigo é o condicionamento acústico da casa de ópera. São discutidos, inicialmente, os pressupostos básicos do ponto de escuta acústico que uma casa de ópera demanda. Os principais condicionantes, como o tempo de reverberação, devem contemplar tanto a música como a fala, o que é uma característica típica de uma casa do gênero. Definidos os materiais a serem utilizados e a concepção arquitetônica, parte-se, em seguida, para uma simulação computacional acústica, visando a determinação de parâmetros de qualidade acústica, como T 20, C 80 e D 50, para receptores distribuídos na plateia e balcões. Esses parâmetros se mostraram satisfatórios para o uso a que se destina o teatro proposto. Na sequência, é elaborada uma aurilização. Esta é preparada para uma ária da ópera “Don Giovanni”, de Mozart, a partir de uma gravação anecoica de uma soprano, interpretando o personagem D. Elvira, e dez instrumentos musicais acompanhantes. O resultado da aurilização - disponível em um link - parece evidenciar a boa qualidade sonora obtida pelo projeto acústico proposto. Guarani, Guarani , Guarani” federal Brasília 100 assentos discutidos inicialmente demanda condicionantes reverberação fala gênero arquitetônica partese, partese parte se, parte-se seguida acústica 20 8 50 balcões proposto sequência Don Giovanni, Giovanni Giovanni” Mozart soprano Elvira acompanhantes 10 2 5 1

ABSTRACT Introduction: Endoscopic Combined Intrarenal Surgery (ECIRS) has emerged as a promising technique for the management of large and complex kidney stones, potentially offering advantages over traditional Percutaneous Nephrolithotomy (PCNL). This study aims to evaluate best practices, outcomes, and future perspectives associated with ECIRS. Materials and Methods: A comprehensive PubMed search was conducted from 2008 to 2024, using MESH terms and the following key words: "ECIRS" and "Endoscopic Combined Intrarenal Surgery" The search yielded 157 articles, including retrospective cohort studies, two randomized controlled trials (RCTs), and four meta-analyses comparing ECIRS with PCNL. Most important findings were summarized regarding indications, patient positioning, kidney access, tract size, surgical outcomes, and complications. Results: ECIRS demonstrated higher stone-free rate, lower complication rate, and a reduced need for multiple procedures compared to traditional PCNL. Additionally, ECIRS has the potential to integrate new technologies to further enhance outcomes. Conclusion: ECIRS demonstrates significant advantages in the management of large kidney stones. Future research should focus on well-designed RCTs to provide robust evidence of its efficacy, safety, and cost-effectiveness, potentially establishing ECIRS as the first option treatment for complex kidney stones. Introduction (ECIRS stones PCNL . (PCNL) practices outcomes Methods 200 2024 words "ECIRS 15 articles studies RCTs, , (RCTs) metaanalyses meta analyses indications positioning access size complications Results stonefree stone free rate Additionally Conclusion welldesigned well designed efficacy safety costeffectiveness, costeffectiveness cost effectiveness, effectiveness cost-effectiveness (PCNL 20 202 1 (RCTs 2

ABSTRACT Introduction: The introduction of Single-Port (SP) platform opened the field to new surgical options, allowing to perform major urological robot-assisted procedures extraperitoneally and with a supine patient positioning (1–3). Nevertheless, a comprehensive description of different supine access options is still lacking (4–6). In this light, we provided a step-by-step guide of SP extraperitoneal supine access options also exploring preliminary surgical outcomes. Materials and methods: Transvesical access was performed by a transversal incision 3cm above the pubic bone, after the anterior abdominal sheet incision, the bladder was insufflated with a flexible cystoscope and the detrusor muscle was incised at the level of the bladder dome. Similarly, the extraperitoneal access was carried out with a 4cm incision above the pubic bone, once visualized the preperitoneal space the prevesical fat was gently spread. The Low Anterior Access was performed with a 3cm incision at the McBurney point, the abdominal muscles were then spread. A gentle dissection was used laterally to develop the retroperitoneal space. Results: Overall, sixteen different procedures were performed with supine extraperitoneal access on 623 consecutive patients. No intraoperative conversions occurred. The median access time was 16 (IQR 12-21), 11 (IQR 7-14) and 14 (IQR 10-18) minutes in case of transvesical, extraperitoneal and low anterior access, respectively. Notably, 81.5 % of patients were discharged on the same day with a postoperative opioid free rate of 73%. Conclusion: The Atlas provides a comprehensive step-by-step guide to successfully perform all major urological SP procedures extraperitoneally and with supine patient positioning. Introduction SinglePort Single Port (SP robotassisted robot assisted 1–3. 13 1–3 . 1 3 (1–3) Nevertheless 4–6. 46 4–6 4 6 (4–6) light stepbystep step outcomes methods cm bone dome Similarly spread point Results Overall 62 occurred IQR 1221, 1221 12 21 , 12-21) 714 7 7-14 1018 10 18 10-18 transvesical respectively Notably 815 81 5 81. 73 73% Conclusion 1– (1–3 4– (4–6 122 2 12-21 71 7-1 101 10-1 8 (1– (4– 12-2 7- 10- (1 (4 12- (

RESUMEN El karaguata es un arbusto de la familia de las bromelias del cual se extrae fibra a fin de producir distintos productos, utilizado como recurso ancestral por las comunidades indígenas del Gran Chaco. La presente investigación tiene como objetivo la descripción del avance de los últimos años del uso del karaguata, teniendo a las comunidades de los Ayoreos de Carmelo Peralta y a los Nivaclé de Boquerón como casos de estudio. El método empleado es de enfoque cualitativo, nivel descriptivo de diseño etnográfico; la técnica es de análisis documental. Por medio de estos estudios se tiene como resultado que estas comunidades aborígenes han adquirido un cierto grado de tecnología y la apertura a un nuevo mercado de comercialización que pueden ofrecer soluciones económicas de desarrollo sustentable. Aunque se obtienen resultados positivos se requiere también tener en cuenta algunos aspectos de suma importancia a fin de sostener las mejoras significativas, como por ejemplo, el aprovisionamiento de la materia prima y el cuidado del valor simbólico y sociocultural de la producción hecha por los pueblos originarios. El artículo es un estudio introductorio a otros que pueden realizarse a futuro y que tengan como enfoque principal el examinar a más profundidad la producción, distribución y comercio del karaguata a nivel país.

ABSTRACT Karaguata is a shrub from the bromeliad family from which fiber is extracted in order to produce different products, used as an ancestral resource by the indigenous communities of the Gran Chaco. The objective of this research is to describe the progress in recent years in the use of Karaguata, taking the communities of the Ayoreos of Carmelo Peralta and the Nivaclé of Boquerón as case studies. The method used is a qualitative approach, descriptive level of ethnographic design; the technique is documentary analysis. Through these studies, the result is that these aboriginal communities have acquired a certain degree of technology and the opening to a new marketing market that can offer economic solutions for sustainable development. Although positive results are obtained, it is also necessary to take into account some extremely important aspects in order to sustain significant improvements, such as, for example, the provision of raw materials and the care of the symbolic and sociocultural value of the production made by the native peoples. The article is an introductory study to others that may be carried out in the future and whose main focus is to examine in more depth the production, distribution and trade of karaguata at the country level.

Abstract: Tensile structures represent a notable evolution of construction materials, from their incipient construction using fabrics made with natural fibers to fabrics developed with high-performance synthetic fibers, which show the transformation of engineering and the design of new materials. The purpose of this document is to explore the use of composite fabrics in permanent tensile structural systems in Ecuador. Exploratory descriptive research is carried out, which identifies the types of application through a systematic classification. The results obtained focus on the characteristics of the use of tensile structures, construction region and detail of the technical, mechanical and physical characteristics, from the structural element approach in tensioned systems.

Resumen: Las estructuras tensadas representan una notable evolución de los materiales de construcción, desde su construcción incipiente mediante telas elaboradas con fibras naturales hasta tejidos desarrollados con fibras sintéticas de altas prestaciones, que muestran la transformación de la ingeniería y el diseño de nuevos materiales. El propósito de este documento es explorar la utilización de tejidos compuestos en sistemas estructurales tensados de carácter permanente en Ecuador. Se lleva a cabo una investigación exploratoria de carácter descriptivo, que identifica los tipos de aplicación mediante una clasificación sistemática. Los resultados obtenidos se centran en las características de uso de las estructuras tensadas, región de construcción y detalle de las características técnicas, mecánicas y físicas, desde el enfoque de elemento estructural en sistemas tensados.

Resumen (Objetivo) Aunque el uso de vídeos de aula no es un tópico novedoso en la formación inicial del profesorado de educación matemática infantil, todavía hay preguntas de investigación sin resolver asociadas, sobre todo, a criterios para seleccionar y analizar vídeos desde un enfoque didáctico y disciplinar. Desde esta perspectiva, la finalidad del artículo es diseñar y validar una rúbrica que sirva para este doble propósito. (Metodología) A partir de un paradigma de investigación cualitativo, se ha seguido un proceso 4x3, es decir, un método secuenciado en cuatro fases con tres pasos en cada una de ellas: 1) revisión, 2) creación, 3) contraste y evaluación, y 4) mejora. (Resultados) La versión definitiva de la rúbrica, denominada R4, consta de 28 ítems organizados en cuatro dimensiones: 1) rol docente, sobre la función que tiene cada docente en el aula; 2) respuesta del alumnado infantil en la tarea, sobre su actuación; 3) relaciones matemáticas, sobre el tipo de matemática; 4) recursos, sobre la gestión y uso de recursos-materiales humanos. Para cada dimensión se considera diversas subdimensiones, en total 16. (Conclusiones) Se concluye que la rúbrica R4 aborda aspectos fundamentales (rol docente, respuesta del alumnado infantil, relaciones matemáticas y recursos) en la labor docente de una maestra o maestro de educación infantil, lo cual permite analizar la práctica docente de un modo holístico y fundamentado.

Resumo (Objetivo) Embora o uso de vídeos em sala de aula não seja um tópico novo na formação inicial de professores de matemática da educação infantil, ainda há questões de pesquisa não resolvidas associadas, sobretudo, aos critérios de seleção e análise de vídeos a partir de uma abordagem didática e disciplinar. A partir dessa perspectiva, o objetivo do artigo é projetar e validar uma rubrica que atenda a essa dupla finalidade. (Metodologia) Com base em um paradigma de pesquisa qualitativa, foi seguido um processo 4x3, ou seja, um método sequenciado em quatro fases com três etapas em cada uma delas: 1) revisão, 2) criação, 3) contraste e avaliação, e 4) aprimoramento. (Resultados) A versão final da rubrica, denominada R4, consiste em 28 itens organizados em quatro dimensões: 1) papel do professor, sobre a função que cada professor tem na sala de aula; 2) resposta dos alunos à tarefa, sobre seu desempenho; 3) relações matemáticas, sobre o tipo de matemática; 4) recursos, sobre o gerenciamento e o uso de recursos humanosmateriais. Para cada dimensão são consideradas diversas subdimensões, totalizando 16. (Conclusões) Conclui-se que a rubrica R4 aborda os principais aspectos (função do professor, resposta dos alunos da educação infantil, recursos e relações matemáticas) no trabalho de ensino de um professor da educação infantil, o que permite uma análise holística e informada da prática de ensino.

Abstract (Objective) Although the use of classroom videos is not a new topic in the initial training of early childhood mathematics education teachers, there are still unresolved research questions associated, above all, with criteria for selecting and analyzing these videos from both a didactic and disciplinary approach. From this perspective, the purpose of this article is to design and validate a rubric that serves this dual purpose. (Methodology) Based on a qualitative research paradigm, a 4x3 process has been followed, that is, a method sequenced in four phases with three steps in each one of them: 1) Review; 2) Creation; 3) Contrast and Evaluation; and 4) Improvement. (Results) The final version of the rubric, called R4, consists of 28 items organized in four dimensions: 1) Teaching role, on the role of the teacher in the classroom; 2) Response of children in the task to his/her performance; 3) Mathematical relations, on the type of mathematics; 4) and Resources, on the management and use of human resources and materials. For each dimension, several subdimensions are considered, 16 in total. (Conclusions) It is concluded that the R4 rubric addresses fundamental aspects (Teaching role, Childrens’ response, Mathematical relations and Resources) in the teaching work of an early childhood education teacher, which allows analyzing the teaching practice in a holistic and justified way.

Abstract In this work we present the first results of prospective and stratigraphic studies in a new archaeological locality located in Paso Gregores (lower basin of the Deseado River, province of Santa Cruz). It is an intermediate space between the sea coast and the interior plateaus of the Deseado Massif. Various archaeological contexts were recorded, among which the rock shelters with the presence of rock art stand out. The locality has an interesting interpretative potential regarding discussions related to the initial settlement and the breadth of the ranges of action of the human groups that occupied the area during the middle and late Holocene. The new evidence of occupation recorded about 50 km from the Atlantic coast, near the limit of the marine influence of the Deseado estuary, is framed in a scenario suitable for discussing the implications of the coast-inland connections and vice versa. The survey of rock paintings, with similar characteristics to sites located to the west, added to their absence on the marine coast, suggests that the occupations in the Paso Gregores Locality would have been structured around ranges of mobility associated with the interior territory, in relationship with the exploitation of guanacos and local raw materials.

Resumen En este trabajo presentamos los primeros resultados de estudios prospectivos y estratigráficos en una nueva localidad arqueológica emplazada en Paso Gregores (cuenca inferior del río Deseado, provincia de Santa Cruz). Se trata de un espacio intermedio entre el litoral marino y las mesetas interiores del Macizo del Deseado. Se registraron variados contextos arqueológicos, entre los que se destacan los abrigos rocosos con presencia de arte rupestre. La localidad posee un interesante potencial interpretativo respecto de discusiones relacionadas con el poblamiento inicial y la amplitud de los rangos de acción de los grupos humanos que ocuparon el área durante el Holoceno medio y tardío. Las nuevas evidencias de ocupación registradas a unos 50 km de la costa atlántica, en cercanías del límite de la influencia marina de la ría Deseado, se enmarcan en un escenario apto para discutir las implicancias de las conexiones costa-interior y viceversa. El relevamiento de pinturas rupestres, con características similares respecto de sitios emplazados hacia el oeste, sumado a su ausencia en el litoral marino, sugiere que las ocupaciones en la Localidad Paso Gregores se habrían estructurado en torno a rangos de movilidad asociados al territorio interior, en relación con la explotación de guanacos y materias primas locales.

Abstract Introduction. In major blood group incompatible bone barrow hematopoietic progenitor cells (HPC-BM) transplant efficient red blood cells (RBC) depletion is essential to minimize adverse effects during and after the product infusion. Different procedures are used to reduce RBC in this case, particularly the hydroxyethyl starch sedimentation (HES) technique is widely used but is very laborious and requires experienced personnel. In this work we show the results of our laboratory in the validation of another methodology for this purpose; processing with Sepax 2 automated equipment, using the SmartRedux v314 protocol. Materials and methods. We evaluated 9 BM hematopoietic progenitor cell products. Data of post processing recovery nucleated cells (NC) and CD34+ cells, viability results, microbiological studies and processing time were obtained. Besides the adverse reactions during the infusion of the products and their engraftment. Results. A mean reduction of GR of 92.5% (88.2 - 95.4%), a recovery of NC of 74.1% (60.1 - 84.3%) and a recovery of CD34+ cells of 83.6% (62.6 - 99.5%) was obtained. The mean viability of CD45+ cells was 93.3% (87% - 98%) and of CD34 cells was 97% (94% - 99%). All microbiology results were negative. After processing, the products were all infused to patients at our institution without relevant adverse reactions, with the median hematopoietic recovery being 15 days for absolute neutrophils and 28 days for platelets. All achieved complete chimerism. Discussion. Having the possibility of implementing a new methodology for the processing of BM progenitor cell products with major blood group incompatibility, the procedure was validated according to the INCUCAI regulations and voluntary standards. An option is proposed for the processing of these products, with advantages and disadvantages. Each center must evaluate and validate the procedure with best adjustment to its needs.

Resumen Introducción. En los trasplantes de células progenitoras hematopoyéticas de médula ósea (CPH-MO) con incompatibilidad mayor de grupo sanguíneo una depleción de glóbulos rojos (GR) eficiente es fundamental para minimizar los efectos adversos durante y posterior a la infusión del producto. Distintos procedimientos se utilizan para la reducción de GR en estos casos, particularmente la técnica de sedimentación con hidroxietil almidón (HES) es ampliamente utilizada, pero es muy laboriosa y requiere de personal experimentado. En este trabajo presentamos los resultados de nuestro laboratorio en la validación de otra metodología para este propósito, el procesamiento con el equipo automatizado Sepax 2, utilizando el protocolo SmartRedux v314. Materiales y métodos. Se evaluaron 9 productos de células progenitoras hematopoyéticas de MO. Se obtuvieron datos de recuperación post procesamiento de células nucleadas (CN) y células CD34+, resultados de viabilidad, estudios microbiológicos y tiempo de procesamiento, además de las reacciones adversas durante la infusión de los productos y datos del injerto de los mismos. Resultados. Se obtuvo una media para la reducción de GR de 92,5% (88,2 - 95,4%), una recuperación de CN de 74,1% (60,1 - 84,3%) y una recuperación de células CD34+ de 83,6% (62,6 - 99,5%). La media de viabilidad de células CD45+ fue 93,3% (87% - 98%) y la de células CD34+ 97% (94% - 99%). Todos los resultados de microbiología fueron negativos. Luego del procesamiento los productos se infundieron todos a pacientes de nuestra institución sin reacciones adversas relevantes, siendo la mediana de recuperación hematopoyética de 15 días para neutrófilos absolutos y de 28 días para plaquetas. Todos lograron quimerismo completo. Discusión. Ante la posibilidad de implementar una nueva metodología para el procesamiento de productos de células progenitoras de MO con incompatibilidad mayor de grupo sanguíneo se validó el procedimiento según establecen las normas de INCUCAI y los estándares voluntarios. Se plantea una opción para el procesamiento de estos productos, con ventajas y desventajas. Cada centro deberá evaluar y validar el procedimiento que mejor se ajuste a sus necesidades.

Este paper discute determinados recortes de uma pesquisa de mestrado em andamento. O presente trabalho tem o objetivo de analisar perfis de Instagram de mulheres defensoras das armas de fogo como instrumento de autodefesa e mapear as redes que formam. O fenômeno do ativismo feminino “pró-armas” está interligado à ascensão da nova direita, ao sentimento de insegurança e de descrédito em relação às instituições estatais, além do lobby armamentista. Tanto na política institucional quanto na sociedade civil são notórios os discursos de mulheres que representam o uso da arma de fogo como estratégia de autodefesa e também como ferramenta de empoderamento feminino. Consonante a isso, fontes de pesquisa atestam o crescimento significativo das fabricantes brasileiras de armas leves na última década no mercado de segurança internacional. A pesquisa, de caráter qualitativo, se baseia em observação etnográfica oculta em ambiente digital e em Análise de Rede Social (ARS) em fase inicial. Os materiais utilizados foram perfis de Instagram das atrizes e organizações sociais de maior circulação no meio da autodefesa armada feminina. Os resultados têm demonstrado: a articulação de símbolos originalmente feministas de empoderamento a velhos signos de feminilidade hegemônica; propostas de autodefesa armada para as mulheres como estratégia frente à violência contra a mulher; e um paralelo entre o crescimento do mercado armamentista e os perfis de ativismo feminino “pró-armas”, devido aos patrocínios às iniciativas das mulheres.

This paper discusses certain excerpts from an ongoing master's research. The present work aims to analyze Instagram profiles of women defenders of firearms as an instrument of selfdefense and to map the networks they form. The phenomenon of pro-gun female activism is interconnected with the rise of the new right, the feeling of insecurity and discredit in relation to state institutions, as well as the gun lobby. Both in institutional politics and in civil society, the discourses of women who represent the use of firearms as a strategy of self-defense and also as a tool for female empowerment are notorious. In line with this, research sources attest to the significant growth of Brazilian manufacturers of small arms in the last decade in the international security market. The research, of a qualitative nature, is based on ethnographic hidden observation in digital environment and on Social Network Analysis (SNA) in the initial phase. The materials used were Instagram profiles of the actresses and social organizations with the greatest circulation in the midst of female armed self-defense. The results have demonstrated: the  articulation of originally feminist symbols of empowerment with old signs of hegemonic femininity; proposals for armed self-defense for women as a strategy against violence against women; and a parallel between the growth of the arms market and the profiles of pro-gun female activism, due to sponsorships of women's initiatives.

En este artículo se discuten algunos extractos de una investigación de maestría en curso. El presente trabajo tiene como objetivo analizar los perfiles de Instagram de mujeres defensoras de armas de fuego como instrumento de autodefensa y mapear las redes que conforman. El fenómeno del activismo femenino pro-armas está interconectado con el ascenso de la nueva derecha, el sentimiento de inseguridad y descrédito en relación con las instituciones estatales, así como con el lobby de las armas. Tanto en la política institucional como en la sociedad civil son notorios los discursos de las mujeres que representan el uso de las armas de fuego como estrategia de autodefensa y también como herramienta de empoderamiento femenino. En línea con esto, fuentes de investigación atestiguan el importante crecimiento de los fabricantes brasileños de armas pequeñas en la última década en el mercado de la seguridad internacional. La investigación, de carácter cualitativo, se basa en la observación etnográfica oculta en un entorno digital y en el Análisis de Redes Sociales (ARS) en la fase inicial. Los materiales utilizados fueron los perfiles de Instagram de las actrices y las organizaciones sociales de mayor circulación en medio de la autodefensa armada femenina. Los resultados han demostrado: la articulación de símbolos de empoderamiento originalmente feministas con viejos signos de feminidad hegemónica; propuestas de autodefensa armada de las mujeres como estrategia contra la violencia hacia las mujeres; y un paralelismo entre el crecimiento del mercado armamentístico y los perfiles de activismo femenino pro-armas, debido al patrocinio de iniciativas de mujeres

Abstract Introduction Permanent education in health aims to ensure that professionals are constantly learning in the workplace and in the last few years institutions resorted to the technology-mediated education modality and new teaching possibilities were explored. In Brazil, between 2017 and 2021, only six articles and five monographs were published about listening effort. Objective The objective of this study was to develop a website with scientific content on the topic listening effort for Speech -Language Therapist and Audiologist with free online access. Methods The study was carried out in five stages: Analysis, contemplating the search for scientific materials to prepare the material. Design, in which the writing and design of the website was carried out. Development, carrying out the adequacy of the online material. Implementation, a stage in which professionals in the area evaluated the quality of the material after consenting to participation through a free and informed consent term. Review, stage in which the researcher analyzed the evaluators' responses. Results The five stages of elaboration of the website were carried out, which was evaluated by professionals in the area. The average of responses to all applied questions rated the website as "superior". Conclusion The website development was validated for online availability. technologymediated technology mediated explored Brazil 201 2021 Language access Analysis Design Development Implementation term Review evaluators superior. superior . "superior" availability 20 202 "superior 2

Abstract Traditional removable partial dentures (RPDs) with cobalt-chromium frameworks have been used for several decades, restoring the masticatory function. However, these frameworks have been documented as aesthetically unacceptable due to the display of metal clasps. The patients' increased demands regarding the aesthetic aspects of rehabilitation treatment led to the introduction of new, more aesthetic materials in clinical practice. One of the main materials is polyetheretherketone (PEEK). This clinical report presents PEEK as an alternative material for fabricating RPD frameworks for a Class III Kennedy partial edentulous mandible. The framework was constructed using CAD/CAM manufacturing, and the process combined laboratory scanning, digital framework design, resin try-in milling, and PEEK framework milling. The framework showed good adaptation to the abutment teeth and surrounding tissues. The patient was followed for 2 years without complaints and was grateful for the aesthetics. During this period, there were no signs of degradation in the framework, and the clasps were still as retentive as they were at the initial appointment, with only some pigmentation of the structure being observed.

Resumo As estruturas das próteses parciais removíveis (PPR) em cobalto-crómio (Co-Cr), utilizadas há várias décadas, têm permitido devolver a função mastigatória aos pacientes parcialmente desdentados. No entanto, estas estruturas não preenchem na totalidade o critério estético, sendo uma queixa recorrente a visibilidade do metal das unidades gancho. Com a crescente exigência estética imposta pelos pacientes em relação ao tratamento reabilitador, surgiu a necessidade do desenvolvimento de novos materiais com esta capacidade. Um material que tem permitido dar resposta a este requisito é o poliéter-éter-cetona (PEEK). O caso clínico apresentado descreve o fabrico da estrutura de uma PRR para a reabilitação de uma desdentação mandibular Classe III de Kennedy, usando o PEEK como material alternativo ao Co-Cr. A estrutura foi construída com tecnologia CAD/CAM. O processo combinou a digitalização dos modelos de gesso em laboratório, desenho digital da estrutura, fresagem duma estrutura de prova em resina e fresagem da estrutura em PEEK. A estrutura mostrou-se bem-adaptada aos dentes pilares e tecidos de suporte. A paciente foi seguida durante 2 anos, tendo-se mostrado muito satisfeita em relação ao tratamento reabilitador, quer quanto ao conforto e função, quer quanto ao resultado estético. Passado este período, a estrutura da PPR não mostrou sinais de degradação e os ganchos apresentavam-se retentivos como na consulta de inserção, observando-se apenas alguma pigmentação da estrutura.

Abstract: The main objective of the discussion presented is to reflect on the logic that underlies the incorporation of technologies in social policies. The article is aimed at the analysis of the genesis of the Index of Critical Deficiencies in Uruguay, as a particular case of an algorithm applied to social selection, especially considering the context of emergence, with the institutional coordinates within which it was created, as well as the discourses that have legitimized and founded its creation, based on the analysis of documents, materials and discourses produced around its creation. In that sense, some warnings are outlined about the illusion of objectivity that is projected in the idea that there is no intentionality behind actions and it is proposed that policies are driven by world visions and linked to interests that condition their creation. Among the final reflections, it is noted that one of the aspects that requires attention is linked to the competencies and powers within the political construction processes. The elimination of human operations, which is what automation is aimed at, means in the case studied the exclusion of subordinate decision-making bodies, as well as the suppression of instances of democratic discussion, and in this exclusion there would seem to be a new centralization of power.

Resumen: La discusión presentada tiene como objetivo principal la reflexión sobre las lógicas que subyacen a la incorporación de tecnologías en las políticas sociales. El artículo se encamina al análisis de la génesis del Índice de Carencias Críticas en Uruguay, como un caso particular de un algoritmo aplicado a la selección social, considerando especialmente el contexto de surgimiento, con las coordenadas institucionales dentro las cuales fue creado, así como también los discursos que han legitimado y fundamentado su creación, a partir del análisis de documentos, materiales y discursos producidos alrededor de su creación. En ese sentido, se esbozan algunas advertencias sobre la ilusión de objetividad que se proyecta en la idea de que no hay intencionalidad detrás de las acciones y se propone que las políticas están impulsadas por visiones de mundo y ligadas a intereses que condicionan su creación. Entre lasreflexiones finales seseñalaqueunodelosaspectos que requiereatención se vincula las competencias y potestades dentro de los procesos de construcciónpolítica.La eliminacióndeoperacioneshumanas, queesaloque se direcciona la automatización, supone en el caso estudiado la exclusión de instancias decisorias subalternas, así como la supresión de instancias de discusión democrática.