The inhibition of the fatty acid amide hydrolase (FAAH), an endocannabinoid system component, emerged as a potentially new therapeutic target for a range of clinical disorders such as acute and chronic pain. Some α-ketoheterocycle derivatives demonstrated interesting analgesic and anti-inflammatory activities in vitro. Ligand-Based Drug Design techniques such as knowledge graph convolutional networks (kGCN) and hologram quantitative structure-activity relationship (HQSAR) using α-ketoheterocycle derivatives from five different datasets were generated to discover the relation between the chemical structures and the inhibition activity. Meanwhile, structure-based drug design simulations as interaction fields (MIF), molecular docking, and ligand sites studies (LSI) from FAAH were performed using Autogrid software and FTmap/FTsite servers. The results of both studies were merged to propose predictive models. The resulting kGCN model demonstrated adequate accuracy area under the curve by receiver operating characteristic (AUC-ROC 0.7922). From contribution maps of the Ligand-Based Drug Design (LBDD) models and the generated probes using MIF and LSI, it was observed that the oxazole ring, the ketone group, and the apolar chain present in the structures of the inhibitors are important, besides the evidence of the Cys269 and Val270 residues importance for the potential interaction, confirmed by carried docking studies. These fragments and structural information can be used to carry out new FAAH potential inhibitors studies and report kGCN as an accurate classification technique. FAAH, , (FAAH) component pain αketoheterocycle α ketoheterocycle antiinflammatory anti inflammatory vitro LigandBased Ligand Based (kGCN structureactivity structure activity HQSAR (HQSAR Meanwhile structurebased based MIF, (MIF) LSI (LSI FTmapFTsite FTmap FTsite servers AUCROC AUC ROC 0.7922. 07922 0.7922 . 0 7922 0.7922) LBDD (LBDD ring group important Cys Cys26 Val Val27 technique (FAAH (MIF 0792 0.792 792 Cys2 Val2 079 0.79 79 07 0.7 7 0.

Parthenolide (PTN) is a secondary metabolite of the plant Tanacetum parthenium (L.) Schulz Bip. and is considered the chemical marker of this species. This sesquiterpene lactone (germacrene skeleton) has been described as responsible for the biological activity of the leaf extract. In addition, several studies in the literature have demonstrated its antiparasitic and antineoplastic activity. However, there is a need for knowledge of other safety parameters, such as pharmacokinetic, pharmacodynamic and toxicity evaluations. Therefore, in this investigation, the in vitro metabolism of parthenolide was performed with rat liver microsomes and biomimetic metabolism (such as cytochrome P-450 system) using organometallic catalysts. The biomimetic procedure was validated since the major compound of biomimetic oxidative reaction with meta-chloroperbenzoic acid catalyzed by metalloporphyrin 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin iron(III) chloride was also observed with rat liver microsomes. Previous chemoenzymatic synthesis studies of PTN afforded the same epoxide formation, this major oxidative compound was isolated and fully characterized as (1 R,10R)-epoxyparthenolide based on experimental and theoretical calculations of infrared (IR) and vibrational circular dichroism (VCD) data at the B3PW91/6-311G. Furthermore, for the first time, this metabolite was evaluated for trypanocidal and leishmanicidal activity. The mean inhibitory concentration (IC50) values were lower for PTN than its metabolite and showed significant cytotoxic effects for both parasites. This finding holds promise for addressing neglected diseases. (PTN L. L (L. Bip species germacrene skeleton extract addition However parameters pharmacokinetic evaluations Therefore investigation P450 P 450 P-45 system catalysts metachloroperbenzoic meta chloroperbenzoic 5,10,15,20tetrakispentafluorophenylporphyrin 5101520tetrakispentafluorophenylporphyrin tetrakispentafluorophenylporphyrin 5,10,15,20 tetrakis pentafluorophenyl porphyrin 5 10 15 20 ironIII iron III iron(III formation 1 ( R,10Repoxyparthenolide R10Repoxyparthenolide RRepoxyparthenolide R,10R epoxyparthenolide R 10R IR (IR VCD (VCD B3PW91/6311G. B3PW916311G BPWG B3PW91/6 311G. B3PW91 6 311G B PW G B3PW91/6-311G Furthermore time IC50 IC (IC50 parasites diseases (L P45 45 P-4 20tetrakispentafluorophenylporphyrin 5101520 5,10,15,2 2 10Repoxyparthenolide Repoxyparthenolide R10R RR 6311G B3PW91/6311G B3PW916 BPW B3PW91/ B3PW9 IC5 (IC5 P4 4 P- 510152 5,10,15, B3PW (IC 51015 5,10,15 5101 5,10,1 510 5,10, 51 5,10 5,1 5,

Lantana caatingensis Moldenke (Verbenaceae) is an endemic plant from northeastern Brazil. However, its chemical composition is almost unknown. This study aimed to characterize the chemical compounds found in L. caatingensis and investigate the antileishmanial potential of its hydroalcoholic extract and polar fractions. Compounds present in the hydroalcoholic extract obtained from L. caatingensis leaves and its polar fractions (ethyl acetate and methanolic) were analyzed by liquid chromatography with a photodiode-array detector coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. An antileishmanial assay was performed in a 96-well plate against Leishmania major promastigotes using resazurin on a plate spectrophotometer and the results were expressed as percentage of growth inhibition. Nine compounds were determined in the investigated extract and fractions, classified as flavonoids, flavonoid C-glycosides and phenylethanoid glycosides. The antileishmanial activity revealed that the hydroalcoholic extract and the ethyl acetate fraction were active against L. major promastigotes with inhibitory concentration of 71.78 and 26.86 µg mL-1, respectively, while the methanolic fraction was inactive (478.40 µg mL-1). This is the first report on the chemical composition and antileishmanial activity of L. caatingensis extracts. These results contribute to further knowledge of species belonging to the Lantana genus. Verbenaceae (Verbenaceae Brazil However unknown L photodiodearray photodiode array timeofflight time flight spectrometry 96well well 96 inhibition flavonoids Cglycosides C glycosides 7178 71 78 71.7 2686 26 86 26.8 mL1, mL1 mL 1, 1 mL-1 respectively 478.40 47840 478 40 (478.4 mL1. . mL-1) extracts genus 9 717 7 71. 268 2 8 26. mL- 478.4 4784 47 4 (478. 478. (478 (47 (4 (

Compared to other species, components of Combretum lanceolatum are still with few data reported in the literature. This work describes the compounds identification, antioxidant and antimicrobial activities of C. lanceolatum twigs. Ethanolic extract (EECLT) from C. lanceolatum twigs was submitted to partition obtaining: hexane (HF), diethyl ether (EEF), ethyl acetate (EAF) and hydromethanolic (HMF) fractions. They were analyzed by gas chromatography-mass spectrometry, high performance liquid chromatography coupled to mass spectrometry and direct insertion mass spectrometry and evaluated for antioxidant assay (2,2-diphenyl-1-picrylhydrazyl (DPPH) method) and antimicrobial assay. Fifty-seven compounds were identified in the fractions. In antioxidant assay, EECLT and EAF demonstrated good antioxidant potential (half maximal effective concentration (EC50): 57.9 and 45.4 µg mL–1, respectively), better than the positive control butylated hydroxytoluene (BHT) (EC50: 69.34 µg mL–1). For antimicrobial assay, all fractions presented promising minimal inhibitory concentration (MIC). EECLT presented the best values against Staphylococcus aureus (125 µg mL–1) and Escherichia coli (62.5 µg mL–1) and better than the positive control fluconazole (8 and 16 µg mL–1) against Candida albicans (3.9 µg mL–1) and Candida krusei (15.6 µg mL–1) strains. This study presents relevant chemical and biological information about C. lanceloatum expanding the knowledge of Brazilian flora. species literature identification C (EECLT obtaining HF, HF , (HF) EEF, EEF (EEF) (EAF HMF (HMF chromatographymass 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl 1 picrylhydrazyl 2 DPPH (DPPH method Fiftyseven Fifty seven half EC50 EC (EC50) 579 57 9 57. 454 45 4 45. mL1 mL mL–1 respectively, respectively respectively) BHT (BHT (EC50 6934 69 34 69.3 mL–1. . MIC. MIC (MIC) 125 (12 62.5 625 62 5 (62. 8 ( 3.9 39 3 (3. 15.6 156 15 6 (15. strains flora (HF (EEF 2diphenyl1picrylhydrazyl 22 2, EC5 mL– (EC5 693 69. (MIC 12 (1 62. (62 3. (3 15. (15 (EC (6

Abstract: This article offers a reflection on the impact of explicit and tacit knowledge on the development of innovations in seven Costa Rican food industry companies that are members of the Costa Rican Chamber of Food Industry (CACIA, in Spanish). This was done with the purpose of deriving implications for the Costa Rican educational system. The research was a qualitative approach, based on the application of semi-structured interviews with officers in each of the companies. The results show that both forms of knowledge play a central role in the achievement of various innovations in each of the organizations. The results also suggest six implications for the education system as a socializing institution and a builder of knowledge and skills for a society that demands innovative people.

Resumo: Este artigo apresenta uma reflexão sobre como o conhecimento explícito e tácito teve impacto no desenvolvimento de inovações em sete empresas do setor alimentar costarriquenho pertencentes à Câmara Costarriquenha da Indústria Alimentar (CACIA). O que foi dito acima é do interesse de derivar implicações para o sistema educativo costarriquenho. A investigação realizada baseouse em um enfoque qualitativo, através da aplicação de entrevistas semiestruturadas a agentes de cada uma das empresas. Os resultados mostram que ambas as formas de conhecimento desempenharam um papel central na consecução de diversas inovações em cada uma das organizações. Ao mesmo tempo, derivam seis implicações para o sistema educativo, na sua condição de instituição socializadora e construtora de conhecimentos e capacidades, para uma sociedade que exige pessoas inovadoras.

Resumen: En este artículo, se presenta una reflexión sobre cómo el conocimiento explícito y tácito tuvo incidencia en el desarrollo de innovaciones en siete empresas del sector alimentario costarricense pertenecientes a la Cámara Costarricense de la Industria Alimentaria (CACIA). Lo anterior con el interés de derivar implicaciones para el sistema educativo costarricense. La investigación realizada se sustentó en un enfoque cualitativo, por medio de la aplicación de entrevistas semiestructuradas a agentes en cada una de las empresas. En los resultados, se constata que ambas formas de conocimiento jugaron un papel central en la consecución de diversas innovaciones, en cada una de las organizaciones. A la vez que derivan seis implicaciones para el sistema educativo, en su condición de institución socializadora y constructora de conocimientos y capacidades, para una sociedad que demanda personas innovadoras.

ABSTRACT This research constitutes a critical-reflexive approach whose aim is to provide criminal law with legitimacy. Its objectives are mainly based on the contributions that critical criminology can make to criminal-legal knowledge so that it can be based on human dignity, as a knowledge that favors the welfare of Latin American society. Because of this, the multifaceted method of criminological criticism is used, which allows not only to observe the real operation of the penal system, but also to transform this reality, deconstructing Latin American penalism. In this sense, the documentary research technique is used to approach different texts on the hypothesis raised to generate inputs to promote a possible epistemological rupture of this legal knowledge regarding its purposes. Thus, some contributions are established for criminal law to leave behind its past of persecution of the excluded, its inherent criminal selectivity, as well as its indolence before the injustices perpetrated by the State through the punitive power, all of which is incompatible with the guarantee premises, and to direct it as a legal knowledge worthy of being called Law and, therefore, destined to prosecute system or global crimes that seriously affect our contemporary societies.

RESUMEN Esta investigación constituye un planteo crítico-reflexivo cuya pretensión es dotar de legitimidad al derecho penal. Sus objetivos se basan principalmente en los aportes que la criminología crítica pueda informar al saber jurídico-penal a fin de que este pueda sustentarse en la dignidad humana, como un saber que propicia el bienestar de la sociedad latinoamericana. Debido a aquello, se utiliza el método polifacético de la crítica criminológica, que permite no solo observar la real operatividad del sistema penal, sino además transformar dicha realidad, deconstruyendo al penalismo latinoamericano. En ese sentido, se emplea la técnica de investigación documental para examinar diversos textos relacionados con la hipótesis propuesta. El objetivo es obtener información que contribuya a promover una potencial ruptura epistemológica en el ámbito de este conocimiento jurídico, especialmente en lo que concierne a sus objetivos fundamentales. Así, se establecen algunos aportes para que el derecho penal deje atrás su pasado de persecución hacia los excluidos, su ínsita selectividad penal, así como su indolencia ante las injusticias que perpetra el Estado a través del poder punitivo, todo lo cual es incompatible con las premisas garantistas, encaminándolo como un saber jurídico digno de llamarse derecho y, por tanto, destinado a perseguir crímenes de sistema o globales que afectan gravemente a nuestras sociedades contemporáneas.

Resumen: En los sistemas educativos, los modelos de gestión se adaptan con la finalidad de fortalecer el sistema en su conjunto, mejorar la calidad educativa y propender al desarrollo del conocimiento. Por lo tanto, las instituciones de educación superior (IES) deben adoptar nuevos modelos de gestión que permita una administración eficiente para alcanzar sus metas. El objetivo del presente estudio ha sido analizar tres modelos de gestión: Garvin, Deming e ISO 21001:2018, mediante un enfoque analítico-sintético-deductivo. Además, se ha buscado hacer una triangulación de información que permita realizar un análisis comparativo, considerando que no existe como regla general un modelo de gestión aplicable debido a que cada institución presenta diversas características, procesos estructuración institucional propia. Por esta razón, se ha planteado una propuesta dirigida a establecer nuevas perspectivas en la gestión de instituciones de educación superior en el que se recogen las mejores prácticas y dimensiones adaptadas a los requerimientos a los que se ven abocados las IES. La propuesta se ha basado en cinco categorías del modelo: procesos, funciones, objetivos-metas, mejora continua y liderazgo, en base a la vigencia, pertinencia y adaptabilidad para las IES, considerando aspectos científicos, tecnológicos y demandas de la sociedad.

Abstract: In educational systems, management models are adapted with the aim of strengthening the system as a whole, improving educational quality and promoting the development of knowledge. Therefore, higher education institutions (HEIs) must adopt new management models that allow efficient administration to achieve their goals. The objective of this study is to analyze three management models: Garvin, Deming and ISO 21001:2018 through an analytical-synthetic-deductive approach, in addition to a triangulation of information that allows for a comparative analysis, considering that there is no general rule of thumb. applicable management model because each institution presents various characteristics, its own institutional structuring processes, which is why a proposal is proposed aimed at establishing new perspectives in the management of higher education institutions in which the best practices and dimensions adapted to the requirements to which HEIs are faced. The proposal is based on five categories of the model: processes, functions, objectives-goals, continuous improvement and leadership, based on validity, relevance and adaptability for HEIs, considering scientific, technological aspects and demands of society.

Abstract Peace education aims to influence the development of a healthy and peaceful coexistence, both in the classroom and in other broader social structures such as the family and the local and global community; It also involves motivating students to understand human rights, multiculturalism and conflict management. The funds of knowledge applied to education constitute a theoretical and methodological approach that values a nd takes into account the experiences and knowledge of families to enrich the design and implementation of sensitive and contextualized educational practices. Here we delve into the importance of implementing funds of knowledge in teaching practices as an approach that promotes peace, because it is based on the principles of inclusion, equity, participation, democracy, solidarity and respect for human rights. The funds of knowledge approach constitutes a contribution to socially just and culturally relevant education that promotes peace because, to live peacefully in a society where people of different cultures, ethnicities, ideologies and languages converge, it is important to live the experience of recognizing, value and respect diversity as the axis that drives the well-being of people and communities.

Resumen La educación para la paz tiene como objetivo incidir en el desarrollo de una convivencia sana y pacífica, tanto en el aula como en otras estructuras sociales más amplias como la familia y la comunidad local y global; implica, además, motivar a los estudiantes a comprender los derechos humanos, la multiculturalidad y el manejo de conflictos. Los fondos de conocimiento aplicados a la educación constituyen un enfoque teórico y metodológico que valora y toma en cuenta las experiencias y conocimientos de las familias para enriquecer el diseño e implementación de prácticas educativas sensibles y contextualizadas. Aquí se profundiza en la importancia de la implementación de los fondos de conocimiento en las prácticas docentes como un enfoque que promueve la paz, porque se basa en los principios de inclusión, equidad, participación, democracia, solidaridad y respeto a los derechos humanos. El enfoque de fondos de conocimiento constituye un aporte a la educación socialmente justa y culturalmente relevante que promueve la paz porque, para convivir de forma pacífica en una sociedad donde convergen personas de diferentes culturas, etnias, ideologías e idiomas, es importante vivir la experiencia de reconocer, valorar y respetar la diversidad como eje que impulsa el bienestar de las personas y las comunidades.

Resumen La moderna Sociedad del Conocimiento percibe una innovadora característica basada en manejar los contenidos curriculares, potenciando el pensamiento lógico matemático por medio de plataformas y aplicaciones digitales. El objetivo del presente trabajo se centraliza en analizar estrategias didácticas aplicadas por docentes para potenciar las habilidades matemáticas en los estudiantes del nivel de Bachillerato General Unificado dentro de la Unidad Educativa “Eidan Abel Erique Cercado” del cantón San Vicente. El aspecto metodológico se basó en el enfoque mixto, empleando como instrumento primordial una prueba pedagógica que mide las destrezas del pensamiento numérico, así como los indicios de una entrevista semi estructurada y los aportes de docentes del área de matemáticas como participantes dentro de un grupo focal. Se comprobó la predisposición para un trabajo orientado bajo la plataforma Khan Academy, necesaria para beneficiar las habilidades del pensamiento numérico poco perfeccionadas en el estudiante. Finalmente, se denotaron aquellas estrategias empleadas por los docentes las cuales no afirman una estimulación consistente para potenciar las habilidades numéricas, demostradas bajo un nivel poco aceptable en el afianzamiento de la resolución de problemas con enfoque matemático en los estudiantes.

Abstract The modern knowledge society perceives an innovative characteristic based on managing curricular contents, promoting mathematical logical thinking through digital platforms and applications, the purpose of this work is focused on determining the existing perception with the use of the Khan Academy platform in the mathematical skills and how teachers focus didactic strategies to enhance mathematical skills in students of the Unified General Baccalaureate level within the "Eidan Abel Erique Cercado" Educational Unit of the San Vicente canton. The methodological aspect was based on the paradigm of the mixed approach, using as a primary instrument a pedagogical test that measures the skills of numerical thinking, as well as the indications of a semi-structured interview and the contributions of teachers in the area of mathematics as participants within a focus group. The predisposition for a work oriented under the Khan Academy platform, necessary to benefit the slightly improved numerical thinking skills in the student, was verified. Finally, those strategies used by teachers were denoted which do not affirm a perennial stimulation to enhance numerical skills, demonstrated under an unacceptable level in the consolidation of problem solving with a mathematical approach in students.

Resumen El objetivo del artículo es conocer los enfoques planteados por las y los activistas que se identifican con el movimiento animalista en Argentina analizando sus percepciones e imaginarios en torno a cómo interpretan la relación entre ambiente y sociedad, el concepto de especismo y el animalismo. Los resultados se desprenden de entrevistas semiestructuradas llevadas a cabo con referentes e integrantes de tres organizaciones animalistas antiespecistas. El análisis se orienta a un enfoque cualitativo para conocer y comprender las percepciones, los imaginarios, las visiones y los enfoques que sus activistas plantean para profundizar en los fundamentos y los saberes colectivos tendientes a la defensa de los animales y a la transformación de la relación especista entre ambiente y sociedad. La estrategia para la recolección de los datos se basó en el muestreo teórico. Se llevaron a cabo 20 entrevistas semiestructuradas con activistas entre 2017 y 2018. El corte temporal abarcó hasta diciembre de 2018.

Abstract The focus of the paper is to review the approaches taken by the activists aligned with the animal rights movement in Argentina, analyzing their perceptions and imaginaries about how they interpret the relationship between environment and society, and the concept of speciesism and animalism. The results presented, emerge from semi-structured interviews carried out with referents and members of three antispeciesist animal rights organizations. The analysis takes a qualitative approach to know and understand the perceptions, imaginaries, visions and approaches that activists propose in order to deepen the foundations and collective knowledge tending to the defense of animals and the transformation of the speciesist relationship between environment and society. The process for data collection was based on theoretical sampling. 20 semi-structured interviews were carried out with activists between 2017 and 2018. The time period covered until December 2018.

RESUMO O objetivo deste estudo foi compreender as representações sociais de jovens que vivem com o HIV. Estudo qualitativo, ancorado na Teoria das Representações Sociais, realizado com 16 jovens em acompanhamento ambulatorial. Os dados foram coletados entre maio e outubro de 2022, por meio de entrevista semiestruturada. Para o tratamento dos dados, empregou-se a técnica de análise lexical, operacionalizada com o auxílio do software Iramuteq. A representação fortemente associada ao diagnóstico de HIV está relacionada ao desconhecimento, preconceito e aceitação, apresentando, também, elementos positivos como recomeço. Classes: Diagnóstico positivo para o HIV: o ‘eu’ de agora; HIV em face do desconhecimento e do estigma; e Relações interpessoais: diálogo, acolhimento e respeito necessários aos jovens. Compreendeu-se que as representações sociais dos jovens com HIV refletem a sua condição na sociedade. Os dados deste estudo mostram que existem formas distintas de vivenciar o HIV, muitas vezes representadas pela fragilidade, pela resignação, e outras, pelo fortalecimento. A fim de minimizar a vulnerabilidade do jovem à exposição ao HIV e aos riscos de conviver com o estigma e preconceito social, fazem-se necessárias a adoção de estratégias de conscientização da sociedade sobre a doença e a ampliação da divulgação de políticas públicas que abarcam essa temática. qualitativo Sociais 1 ambulatorial 2022 semiestruturada empregouse empregou se lexical Iramuteq aceitação apresentando também recomeço Classes ‘eu eu agora interpessoais diálogo Compreendeuse Compreendeu fragilidade resignação outras fortalecimento social fazemse fazem temática 202 20 2

ABSTRACT This study was aimed at understanding the social representations of young people living with HIV. This is a qualitative study, based on the Social Representations Theory, carried out with 16 young people in outpatient follow-up. Data were collected between May and October 2022, through semi-structured interviews. For data processing, the lexical analysis technique was used, operationalized with the aid of the IRAMUTEQ software. The representation strongly associated with the diagnosis of HIV is related to lack of knowledge, prejudice and acceptance, also presenting positive elements such as a new beginning. Classes: Positive diagnosis for HIV: the new ‘me’; HIV in the face of ignorance and stigma; and Interpersonal relationships: dialogue, acceptance and respect necessary for young people. It was understood that the social representations of young people with HIV reflect their condition in society. The data show that there are different ways of experiencing HIV, often represented by fragility, resignation, and other times by strengthening. In order to minimize the vulnerability of young people to exposure to HIV and the risks of living with stigma and social prejudice, it is necessary to adopt strategies to raise awareness about the disease and to expand the dissemination of public policies that cover this topic. Theory 1 followup. followup follow up. up follow-up 2022 semistructured semi structured interviews processing used software knowledge beginning Classes ‘me me ‘me’ relationships dialogue society fragility resignation strengthening topic 202 20 2

RESUMEN En un entorno donde la falta de conocimiento tributario y la evasión fiscal son desafíos significativos, este estudio se propone analizar estrategias efectivas para mejorar la conciencia tributaria mediante la capacitación en educación fiscal. Se revisaron diversas investigaciones que resaltan la importancia de programas específicos de instrucción tributaria y alianzas con el sistema educativo desde edades tempranas. Los resultados indican que la implementación de programas de capacitación y la promoción de la transparencia en la gestión pública pueden fortalecer la comprensión de los contribuyentes sobre sus obligaciones fiscales, promoviendo así un mayor cumplimiento voluntario. Se concluye que una educación fiscal adecuada, combinada con incentivos fiscales y tecnologías educativas innovadoras, puede contribuir de manera significativa a la formación de una cultura tributaria sólida y al fortalecimiento de la confianza en el sistema tributario.

ABSTRACT In an environment where lack of tax knowledge and tax evasion are significant challenges, this study aims to analyze effective strategies to improve tax awareness through tax education training. Several research studies were reviewed that highlight the importance of specific tax education programs and alliances with the educational system from an early age. The results indicate that the implementation of training programs and the promotion of transparency in public management can strengthen taxpayers' understanding of their tax obligations, thus promoting greater voluntary compliance. It is concluded that adequate tax education, combined with tax incentives and innovative educational technologies, can contribute significantly to the formation of a solid tax culture and to the strengthening of trust in the tax system.

Abstract The leading capacity and effectiveness of democratic governments is the reference of the article, which assumes the reasons why the concept of governance was restored and revitalized in the 90s of the past century, causing “the shift of government to governance”. The text offers a panoramic perspective of the governance concept, defines its essential properties ―intentional action, according to the state normative order, and causal action, according to the social system of knowledge―, explains the couple of its main fields ―governance of society and governance of the public organizations―, its types ―govern, self-govern, cogovern, subsidiarity― and develops the properties of the new public governance in accordance with the structure of the contemporary social system. The article ends with two set of considerations, regarding the rules and guidelines to support the institutional and executive quality of citizens participation in the governance of public issues, as well as some basic features of the governance of public organizations (“government governance”).

Resumen La capacidad y efectividad directiva de los gobiernos democráticos es el marco de referencia de este artículo, que expone los motivos que causaron “el desplazamiento del gobierno a la gobernanza” e hicieron renacer el concepto de gobernanza o nueva gobernanza pública en la década de 1990. El texto ofrece un panorama del concepto de gobernanza, define sus propiedades esenciales ―acción intencional con referencia al ordenamiento normativo del Estado y acción causal con referencia al sistema social de conocimientos―, enuncia sus ámbitos de gestión ―gobernanza de la sociedad y gobernanza de las entidades públicas―, especifica sus tipos (gobierno, autogobierno, cogobierno, subsidiaridad) y explica la aparición de la nueva gobernanza o cogobernanza, acorde con la complejidad del sistema de sociedad contemporáneo. Se concluye con un par de consideraciones sobre las normas y directrices que aseguran la calidad institucional y ejecutiva de la participación ciudadana en el nuevo modo de gobernar y sobre la gobernanza o alta dirección de las entidades públicas mediante las cuales el gobierno gobierna a la sociedad.

Abstract The National Institute of Biodiversity of Costa Rica (INBio), the first institution of its kind worldwide, was created in 1989 as a civil society organization, with the mission of promoting greater awareness of the value of biodiversity, to achieve its conservation and promote human development. It operated within the framework of a national biodiversity conservation strategy consisting of three types of actions: “save, know and use”, forming a publicprivate alliance with the National System of Conservation Areas, whose work represented the first step of “saving”. INBio focused on the generation of scientific knowledge of Costa Rican biodiversity (knowing) and the search and promotion of its intelligent use (using). This article describes the genesis of the institution and its main contributions to the knowledge and use of Costa Rican biodiversity between 1989-2015. These include the results of the protected areas biodiversity inventory process and the development of the largest systematic collection of biological specimens in the country’s history, fully systematized; the development of an information management system that integrated all the information from the inventory and the specimens in its collection in digital format, allowing global access to this information or its correlation with that of other sources. The results of promoting and facilitating the use of information through five programs: Natural Sciences and Conservation Biology, for scientific purposes; Bioliteracy and Education, conceptually designed for the teaching and development of awareness about the value of biodiversity; Bioprospecting, the systematic search for economic uses of biodiversity for medicinal, agricultural and industrial purposes; Conservation for Development, the use of the information for wild areas conservation purposes, surrounding communities or nature tourism, among others; Technical Assistance and Training, program in charge of assisting public and private entities, inside and outside the country, in the development of initiatives in which Biodiversity was the central element. The main results of its work and the national and international awards that INBio received for its innovative approaches and contributions are described, as well as the financial and political reasons why INBio discontinued its activities in the period 2015-2016 are summarized. Viewing the work of INBio as a first stage, the importance and need to continue with a state program on the knowledge and use of Costa Rican biodiversity is raised, in addition to its protection, with the goal of creating awareness of its value before the serious threats to life on Earth.

Resumen El Instituto Nacional de Biodiversidad de Costa Rica (INBio), la primera institución en su género en el mundo, fue creado en 1989 como una organización de la sociedad civil, con la misión expresa de promover una mayor conciencia del valor de la biodiversidad, para lograr su conservación y fomentar el desarrollo humano. En el marco de una estrategia nacional de conservación de la biodiversidad consistente en tres tipos de acciones: “salvar, conocer y utilizar”, se conformó una alianza público-privada con el Sistema Nacional de Áreas de Conservación, cuya labor representó el primer paso de “salvar”. El INBio se centró en la generación de conocimiento científico de la biodiversidad costarricense (el “conocer”) y en la búsqueda y promoción de su uso inteligente (el “usar”). Este artículo describe la génesis de la institución y sus principales aportes al conocimiento y la utilización de la biodiversidad costarricense en el período 1989-2015. Estos incluyen los resultados del proceso de inventario de la biodiversidad de las áreas protegidas y el desarrollo de la colección sistemática de especímenes biológicos más grande en la historia del país, totalmente sistematizada; el desarrollo de un sistema de manejo de información que integró en formato digital toda la información del inventario y de los especímenes de su colección, permitiendo el acceso global a estos datos o su correlación con la de otras fuentes. Los resultados de la promoción y la facilitación del uso de la información se lograron mediante cinco programas: Ciencias Naturales y Biología de la Conservación, con fines científicos; Bioalfabetización y Educación, conceptualmente diseñados para la enseñanza y el desarrollo de la conciencia del valor de la biodiversidad; Bioprospección, la búsqueda sistemática de usos económicos de la biodiversidad para fines medicinales, agrícolas e industriales; Conservación para el Desarrollo, el empleo de la información para la conservación de áreas silvestres, comunidades circunvecinas o turismo naturalista, entre otros; y Asistencia Técnica y Capacitación, programa encargado de asistir a entidades públicas y privadas, dentro y fuera del país, en el desarrollo de iniciativas en que la biodiversidad fuera el elemento central. Se describen los principales resultados de su labor y los reconocimientos nacionales e internacionales que el INBio recibió por sus novedosos enfoques y aportes, al igual que se resumen las razones de carácter financiero y político por las cuales el INBio descontinuó sus actividades en el período 2015-2016. Vista la labor del INBio como una primera etapa, se plantea la importancia y necesidad de continuar con un programa estatal sobre el conocimiento y uso de la biodiversidad costarricense, en adición a su protección, con el fin último de que exista conciencia de su valor ante las serias amenazas para la vida en el planeta.

RESUMEN El docente universitario debe gestionar el proceso de enseñanza-aprendizaje en el contexto de las relaciones que se establecen entre la sociedad, la tecnología, la ciencia y el medio ambiente. Estudios realizados corroboran insuficiencias en la orientación didáctica para gestionar la comprensión de los contenidos lingüísticos y literarios; de ahí que el objetivo de este artículo es la elaboración de un conjunto de acciones didáctico-metodológicas que favorezcan la gestión del conocimiento en función de su aprendizaje durante la formación del profesor de Español-Literatura. Para ello, se realizó una revisión bibliográfica y análisis documental relacionado con las categorías que se desarrollan.

ABSTRACT The university teacher must manage the teaching-learning process in the context of the relationships established between society, technology, science and the environment. Studies carried out corroborate insufficiencies in the didactic orientation to manage the understanding of linguistic and literary contents; hence, the objective of this article is the elaboration of a set of didactic-methodological actions that favor the management of knowledge in terms of its learning during the training of the Spanish-Literature teacher. For this purpose, a bibliographic review and documentary analysis related to the categories developed were carried out.