Parthenolide (PTN) is a secondary metabolite of the plant Tanacetum parthenium (L.) Schulz Bip. and is considered the chemical marker of this species. This sesquiterpene lactone (germacrene skeleton) has been described as responsible for the biological activity of the leaf extract. In addition, several studies in the literature have demonstrated its antiparasitic and antineoplastic activity. However, there is a need for knowledge of other safety parameters, such as pharmacokinetic, pharmacodynamic and toxicity evaluations. Therefore, in this investigation, the in vitro metabolism of parthenolide was performed with rat liver microsomes and biomimetic metabolism (such as cytochrome P-450 system) using organometallic catalysts. The biomimetic procedure was validated since the major compound of biomimetic oxidative reaction with meta-chloroperbenzoic acid catalyzed by metalloporphyrin 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin iron(III) chloride was also observed with rat liver microsomes. Previous chemoenzymatic synthesis studies of PTN afforded the same epoxide formation, this major oxidative compound was isolated and fully characterized as (1 R,10R)-epoxyparthenolide based on experimental and theoretical calculations of infrared (IR) and vibrational circular dichroism (VCD) data at the B3PW91/6-311G. Furthermore, for the first time, this metabolite was evaluated for trypanocidal and leishmanicidal activity. The mean inhibitory concentration (IC50) values were lower for PTN than its metabolite and showed significant cytotoxic effects for both parasites. This finding holds promise for addressing neglected diseases. (PTN L. L (L. Bip species germacrene skeleton extract addition However parameters pharmacokinetic evaluations Therefore investigation P450 P 450 P-45 system catalysts metachloroperbenzoic meta chloroperbenzoic 5,10,15,20tetrakispentafluorophenylporphyrin 5101520tetrakispentafluorophenylporphyrin tetrakispentafluorophenylporphyrin 5,10,15,20 tetrakis pentafluorophenyl porphyrin 5 10 15 20 ironIII iron III iron(III formation 1 ( R,10Repoxyparthenolide R10Repoxyparthenolide RRepoxyparthenolide R,10R epoxyparthenolide R 10R IR (IR VCD (VCD B3PW91/6311G. B3PW916311G BPWG B3PW91/6 311G. B3PW91 6 311G B PW G B3PW91/6-311G Furthermore time IC50 IC (IC50 parasites diseases (L P45 45 P-4 20tetrakispentafluorophenylporphyrin 5101520 5,10,15,2 2 10Repoxyparthenolide Repoxyparthenolide R10R RR 6311G B3PW91/6311G B3PW916 BPW B3PW91/ B3PW9 IC5 (IC5 P4 4 P- 510152 5,10,15, B3PW (IC 51015 5,10,15 5101 5,10,1 510 5,10, 51 5,10 5,1 5,

Compared to other species, components of Combretum lanceolatum are still with few data reported in the literature. This work describes the compounds identification, antioxidant and antimicrobial activities of C. lanceolatum twigs. Ethanolic extract (EECLT) from C. lanceolatum twigs was submitted to partition obtaining: hexane (HF), diethyl ether (EEF), ethyl acetate (EAF) and hydromethanolic (HMF) fractions. They were analyzed by gas chromatography-mass spectrometry, high performance liquid chromatography coupled to mass spectrometry and direct insertion mass spectrometry and evaluated for antioxidant assay (2,2-diphenyl-1-picrylhydrazyl (DPPH) method) and antimicrobial assay. Fifty-seven compounds were identified in the fractions. In antioxidant assay, EECLT and EAF demonstrated good antioxidant potential (half maximal effective concentration (EC50): 57.9 and 45.4 µg mL–1, respectively), better than the positive control butylated hydroxytoluene (BHT) (EC50: 69.34 µg mL–1). For antimicrobial assay, all fractions presented promising minimal inhibitory concentration (MIC). EECLT presented the best values against Staphylococcus aureus (125 µg mL–1) and Escherichia coli (62.5 µg mL–1) and better than the positive control fluconazole (8 and 16 µg mL–1) against Candida albicans (3.9 µg mL–1) and Candida krusei (15.6 µg mL–1) strains. This study presents relevant chemical and biological information about C. lanceloatum expanding the knowledge of Brazilian flora. species literature identification C (EECLT obtaining HF, HF , (HF) EEF, EEF (EEF) (EAF HMF (HMF chromatographymass 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl 1 picrylhydrazyl 2 DPPH (DPPH method Fiftyseven Fifty seven half EC50 EC (EC50) 579 57 9 57. 454 45 4 45. mL1 mL mL–1 respectively, respectively respectively) BHT (BHT (EC50 6934 69 34 69.3 mL–1. . MIC. MIC (MIC) 125 (12 62.5 625 62 5 (62. 8 ( 3.9 39 3 (3. 15.6 156 15 6 (15. strains flora (HF (EEF 2diphenyl1picrylhydrazyl 22 2, EC5 mL– (EC5 693 69. (MIC 12 (1 62. (62 3. (3 15. (15 (EC (6

The inhibition of the fatty acid amide hydrolase (FAAH), an endocannabinoid system component, emerged as a potentially new therapeutic target for a range of clinical disorders such as acute and chronic pain. Some α-ketoheterocycle derivatives demonstrated interesting analgesic and anti-inflammatory activities in vitro. Ligand-Based Drug Design techniques such as knowledge graph convolutional networks (kGCN) and hologram quantitative structure-activity relationship (HQSAR) using α-ketoheterocycle derivatives from five different datasets were generated to discover the relation between the chemical structures and the inhibition activity. Meanwhile, structure-based drug design simulations as interaction fields (MIF), molecular docking, and ligand sites studies (LSI) from FAAH were performed using Autogrid software and FTmap/FTsite servers. The results of both studies were merged to propose predictive models. The resulting kGCN model demonstrated adequate accuracy area under the curve by receiver operating characteristic (AUC-ROC 0.7922). From contribution maps of the Ligand-Based Drug Design (LBDD) models and the generated probes using MIF and LSI, it was observed that the oxazole ring, the ketone group, and the apolar chain present in the structures of the inhibitors are important, besides the evidence of the Cys269 and Val270 residues importance for the potential interaction, confirmed by carried docking studies. These fragments and structural information can be used to carry out new FAAH potential inhibitors studies and report kGCN as an accurate classification technique. FAAH, , (FAAH) component pain αketoheterocycle α ketoheterocycle antiinflammatory anti inflammatory vitro LigandBased Ligand Based (kGCN structureactivity structure activity HQSAR (HQSAR Meanwhile structurebased based MIF, (MIF) LSI (LSI FTmapFTsite FTmap FTsite servers AUCROC AUC ROC 0.7922. 07922 0.7922 . 0 7922 0.7922) LBDD (LBDD ring group important Cys Cys26 Val Val27 technique (FAAH (MIF 0792 0.792 792 Cys2 Val2 079 0.79 79 07 0.7 7 0.

Lantana caatingensis Moldenke (Verbenaceae) is an endemic plant from northeastern Brazil. However, its chemical composition is almost unknown. This study aimed to characterize the chemical compounds found in L. caatingensis and investigate the antileishmanial potential of its hydroalcoholic extract and polar fractions. Compounds present in the hydroalcoholic extract obtained from L. caatingensis leaves and its polar fractions (ethyl acetate and methanolic) were analyzed by liquid chromatography with a photodiode-array detector coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. An antileishmanial assay was performed in a 96-well plate against Leishmania major promastigotes using resazurin on a plate spectrophotometer and the results were expressed as percentage of growth inhibition. Nine compounds were determined in the investigated extract and fractions, classified as flavonoids, flavonoid C-glycosides and phenylethanoid glycosides. The antileishmanial activity revealed that the hydroalcoholic extract and the ethyl acetate fraction were active against L. major promastigotes with inhibitory concentration of 71.78 and 26.86 µg mL-1, respectively, while the methanolic fraction was inactive (478.40 µg mL-1). This is the first report on the chemical composition and antileishmanial activity of L. caatingensis extracts. These results contribute to further knowledge of species belonging to the Lantana genus. Verbenaceae (Verbenaceae Brazil However unknown L photodiodearray photodiode array timeofflight time flight spectrometry 96well well 96 inhibition flavonoids Cglycosides C glycosides 7178 71 78 71.7 2686 26 86 26.8 mL1, mL1 mL 1, 1 mL-1 respectively 478.40 47840 478 40 (478.4 mL1. . mL-1) extracts genus 9 717 7 71. 268 2 8 26. mL- 478.4 4784 47 4 (478. 478. (478 (47 (4 (

RESUMEN El objetivo general fue analizar el mecanismo a través del cual la academia puede contribuir al logro de los Objetivos de Desarrollo Sostenible (ODS) en Paraguay. Ante la necesidad de visibilizar esta contribución por parte de la academia, se remarca el propósito del estudio, intercambiar experiencias de cómo puede la academia colaborar al logro de los ODS, la importancia de difundir informaciones relacionadas a los ODS y, sobre todo, indagar el grado de conocimiento de los ODS de personas clave de organizaciones o instituciones de las distintas comunidades de la zona de influencia de la sede Central y las Filiales de la FCE-UNA. El estudio analítico-descriptivo, está basado esencialmente en un trabajo de campo, con relevamiento de datos definida como población objetivo a líderes comunitarios. Los resultados obtenidos permiten afirmar que la visión de los líderes sobre el rol de las universidades para el logro de los ODS en Paraguay, refieren a que su rol es fundamental para el logro de los ODS y también mencionan que su rol es ser nexo con la sociedad para el logro de los ODS. Se concluye que el mecanismo óptimo a través del cual la academia/universidad puede contribuir al logro de los ODS en Paraguay, seria preferentemente incluir el tema de los ODS en el currículo de las facultades y brindar cursos sobre los ODS; otro, además sería elaborar e implementar proyectos en línea de los ODS, al que se agregan, el asesorar a las instituciones responsables del cumplimiento de los ODS.

ABSTRACT The overarching objective was to examine the manner in which academic institutions can contribute to the attainment of the Sustainable Development Goals (SDGs) in Paraguay. In light of the necessity to make this contribution by academia visible, the objective of the study is to facilitate an exchange of experiences on how academia can collaborate to achieve the Sustainable Development Goals (SDGs), the importance of disseminating information related to the SDGs, and, most importantly, to investigate the degree of knowledge of the SDGs among key individuals from organizations or institutions in various communities within the area of influence of the Central Headquarters and the Branches of FCE-UNA. The study is primarily analytical and descriptive in nature, with a particular focus on fieldwork and the collection of data from community leaders. The findings indicate that the leaders perceive the role of universities in achieving the SDGs in Paraguay to be of paramount importance. Furthermore, they assert that their role is to serve as a conduit between society and the achievement of the SDGs. It is thus concluded that the most effective mechanism through which academia/ universities can contribute to the achievement of the SDGs in Paraguay would be to integrate the topic of the SDGs into the curricula of the faculties and to offer courses on the SDGs. Additionally, another avenue for contribution would be the development and implementation of SDG-aligned projects, in collaboration with institutions responsible for achieving the SDGs

Resumo: Este artigo apresenta uma reflexão sobre como o conhecimento explícito e tácito teve impacto no desenvolvimento de inovações em sete empresas do setor alimentar costarriquenho pertencentes à Câmara Costarriquenha da Indústria Alimentar (CACIA). O que foi dito acima é do interesse de derivar implicações para o sistema educativo costarriquenho. A investigação realizada baseouse em um enfoque qualitativo, através da aplicação de entrevistas semiestruturadas a agentes de cada uma das empresas. Os resultados mostram que ambas as formas de conhecimento desempenharam um papel central na consecução de diversas inovações em cada uma das organizações. Ao mesmo tempo, derivam seis implicações para o sistema educativo, na sua condição de instituição socializadora e construtora de conhecimentos e capacidades, para uma sociedade que exige pessoas inovadoras.

Resumen: En este artículo, se presenta una reflexión sobre cómo el conocimiento explícito y tácito tuvo incidencia en el desarrollo de innovaciones en siete empresas del sector alimentario costarricense pertenecientes a la Cámara Costarricense de la Industria Alimentaria (CACIA). Lo anterior con el interés de derivar implicaciones para el sistema educativo costarricense. La investigación realizada se sustentó en un enfoque cualitativo, por medio de la aplicación de entrevistas semiestructuradas a agentes en cada una de las empresas. En los resultados, se constata que ambas formas de conocimiento jugaron un papel central en la consecución de diversas innovaciones, en cada una de las organizaciones. A la vez que derivan seis implicaciones para el sistema educativo, en su condición de institución socializadora y constructora de conocimientos y capacidades, para una sociedad que demanda personas innovadoras.

Abstract: This article offers a reflection on the impact of explicit and tacit knowledge on the development of innovations in seven Costa Rican food industry companies that are members of the Costa Rican Chamber of Food Industry (CACIA, in Spanish). This was done with the purpose of deriving implications for the Costa Rican educational system. The research was a qualitative approach, based on the application of semi-structured interviews with officers in each of the companies. The results show that both forms of knowledge play a central role in the achievement of various innovations in each of the organizations. The results also suggest six implications for the education system as a socializing institution and a builder of knowledge and skills for a society that demands innovative people.

RESUMEN Esta investigación constituye un planteo crítico-reflexivo cuya pretensión es dotar de legitimidad al derecho penal. Sus objetivos se basan principalmente en los aportes que la criminología crítica pueda informar al saber jurídico-penal a fin de que este pueda sustentarse en la dignidad humana, como un saber que propicia el bienestar de la sociedad latinoamericana. Debido a aquello, se utiliza el método polifacético de la crítica criminológica, que permite no solo observar la real operatividad del sistema penal, sino además transformar dicha realidad, deconstruyendo al penalismo latinoamericano. En ese sentido, se emplea la técnica de investigación documental para examinar diversos textos relacionados con la hipótesis propuesta. El objetivo es obtener información que contribuya a promover una potencial ruptura epistemológica en el ámbito de este conocimiento jurídico, especialmente en lo que concierne a sus objetivos fundamentales. Así, se establecen algunos aportes para que el derecho penal deje atrás su pasado de persecución hacia los excluidos, su ínsita selectividad penal, así como su indolencia ante las injusticias que perpetra el Estado a través del poder punitivo, todo lo cual es incompatible con las premisas garantistas, encaminándolo como un saber jurídico digno de llamarse derecho y, por tanto, destinado a perseguir crímenes de sistema o globales que afectan gravemente a nuestras sociedades contemporáneas.

ABSTRACT This research constitutes a critical-reflexive approach whose aim is to provide criminal law with legitimacy. Its objectives are mainly based on the contributions that critical criminology can make to criminal-legal knowledge so that it can be based on human dignity, as a knowledge that favors the welfare of Latin American society. Because of this, the multifaceted method of criminological criticism is used, which allows not only to observe the real operation of the penal system, but also to transform this reality, deconstructing Latin American penalism. In this sense, the documentary research technique is used to approach different texts on the hypothesis raised to generate inputs to promote a possible epistemological rupture of this legal knowledge regarding its purposes. Thus, some contributions are established for criminal law to leave behind its past of persecution of the excluded, its inherent criminal selectivity, as well as its indolence before the injustices perpetrated by the State through the punitive power, all of which is incompatible with the guarantee premises, and to direct it as a legal knowledge worthy of being called Law and, therefore, destined to prosecute system or global crimes that seriously affect our contemporary societies.

Abstract This article seeks to analyze the Jesuit rhetoric in the work Historia de los trivmphos de nuestra santa fee entre gentes las más bárbaras y fieras del nueuo orbe, written by the Cordovan Andrés Pérez de Ribas and published in 1645, highlighting the issues related to the survival of idolatry and the influence of the devil on the Indians who inhabited the northern missions. Although the chronicle of this Jesuit has been analyzed from different historiographical perspectives, we intend to trace those relevant testimonies that describe the conception that the members of the Ignatian society held about those practices and local conceptions of the world contrary to the Christian faith, highlighting the importance and the role that the missionary writing took for the conformation and diffusion of these narratives. In this sense, it is proposed to focus on the so-called “Jesuit knowledge”, emphasizing the rhetorical corpus related to the apologetic purposes of the conversion of the gentiles. To achieve the proposed objective, the article is divided into the following sections: the establishment of the Jesuit missions in the province of Sinaloa, the life and trajectory of the Jesuit Pérez de Ribas, and the rhetoric of “evil” present in his written work.

Resumen El presente artículo busca analizar la retórica jesuítica en la obra Historia de los trivmphos de nuestra santa fee entre gentes las más bárbaras y fieras del nueuo orbe, escrita por el cordobés Andrés Pérez de Ribas, publicada en 1645, para destacar los temas referentes a la pervivencia de la idolatría y a la influencia del demonio sobre los indios que habitaban las misiones norteñas. Si bien esta crónica ha sido analizada desde distintas perspectivas historiográficas, se pretende rastrear aquellos testimonios relevantes que describen la concepción que los miembros de la sociedad ignaciana mantenían sobre aquellas prácticas y cosmovisiones locales contrarias a la fe cristiana, a fin de resaltar la importancia y el papel que la escritura misionera tomó para la conformación y la difusión de estas narrativas. En este sentido, se propone colocar la mirada en los denominados “saberes jesuíticos”, con énfasis en el corpus retórico relacionado con los propósitos apologéticos de la conversión de los gentiles. Para lograr el objetivo planteado, el artículo se divide en los siguientes apartados: el establecimiento de las misiones jesuitas en la provincia de Sinaloa, la vida y trayectoria del jesuita Pérez de Ribas y la retórica del “mal” presente en su obra escrita.

SUMMARY: The denomination of the "ulna" bone as "cubitus" bone is an error in terminology still observed in anatomy study texts and Chilean school textbooks, even though the term ulna was established as the official term in the 20th century. This problem is a reflection of the slow progressive change in academic communities and the population in general, through the traditional transfer of knowledge. Scientific dissemination allows for accelerating such a process, and in recent years, it has been enhanced through social networks and virtual platforms such as TikTok. Few studies relate the use of TikTok with anatomical learning. This research describes school students' perception of an informative video on correctly using the term "ulna." It analyzes the possible scope as a complementary activity to anatomical teaching for the school community and society. A TikTok video was developed and published four months before showing it to 17 11th-grade students from Viña del Mar, and then they were asked to complete a perception survey. In addition, statistical data provided by the TikTok platform itself was recorded. The results revealed a favorable reception of the informative content among the participating students, with a high percentage expressing total or partial agreement in all the statements evaluated (up to 82.4 %). The metrics delivered by the platform show an international reach, the main viewers being people from Chile (35.5 %), Mexico (25.3 %), and Colombia (7.2 %). Among the aspects mentioned by the students that need improvement, are the quality of visual editing and the fluency of the explanation. Given the positive perception obtained from the video, we consider that using these complementary tools can improve human anatomy's teaching and learning processes and broaden our practices' impact on the educational community and society.

RESUMEN: La denominación del hueso "ulna" como hueso "cúbito" es un error de terminología aún observado en textos de estudio de anatomía y en textos escolares chilenos, pese a que desde el siglo XX se ha establecido el término ulna como el oficial. Esto refleja la lentitud del proceso de cambio en las comunidades académicas y en la población general mediante la transmisión tradicional de conocimientos. La divulgación científica permite acelerar dicho proceso, y en los últimos años se ha potenciado por medio de redes sociales y plataformas virtuales como TikTok. Existen pocos estudios que relacionan el uso de TikTok con el aprendizaje anatómico. Esta investigación describe la percepción de estudiantes escolares frente a un vídeo divulgativo sobre el correcto uso del término "ulna" y analiza los posibles alcances como actividad complementaria de la enseñanza anatómica hacia la comunidad escolar y la sociedad. Se desarrolló un vídeo de TikTok publicado 4 meses antes de mostrarlo a 17 estudiantes de 3° de enseñanza secundaria, y luego se les solicitó completar una encuesta de percepción. Además, se registraron datos estadísticos entregados por la misma plataforma. Los resultados obtenidos revelan una favorable acogida del contenido divulgativo entre los estudiantes participantes, con un alto porcentaje expresando acuerdo total o parcial en todas las afirmaciones evaluadas (hasta un 82,4 %). Las métricas entregadas por la plataforma demuestran un alcance internacional, siendo los principales espectadores personas de Chile (35,5 %), México (25,3 %) y Colombia (7,2 %). Entre los aspectos a mejorar mencionados por los estudiantes está la calidad de edición visual y la fluidez de la explicación. Dada la positiva percepción obtenida frente al vídeo, consideramos que usar estas herramientas complementarias puede mejorar los procesos de enseñanza y aprendizaje de la anatomía humana y ampliar el impacto de nuestras prácticas en la comunidad educativa y la sociedad.

The National Development Plan (NDP) advocates for the elimination of poverty, and the reduction of inequality by 2030. These goals can only be achieved if we harness the energies of the people, build an inclusive economy, develop skills, improve the capacity of the state and promote leadership and partnerships across society. This is to be achieved through transforming society more equitably and at the same time making the country more competitive in the global economic system. The article seeks to explore how institutions of higher learning can be transformed through the production of future professors with a developmental agenda. Therefore, the NDP advocates continuous professional development, lifelong learning and knowledge production, and innovation as a focus for building the capacity of individuals and society. The article employed the modernisation theory as a vehicle to drive social change and transformation in higher education. The article employed a systematic review of the literature on transformation and social change in higher education as advocated in the NDP. The findings of the article show that universal human development can be achieved by respecting human rights, promoting equality and empowering people to exercise the opportunities and choices they value in higher education. The article recommends that a structured interaction between lecturers and students within the context of transformative change and social justice should be prioritised in higher education. This can only be achieved through preparing the future professor with a developmental agenda to assist in shaping higher education by designing a curriculum that responds to the needs of the current cohort of students.

ABSTRACT Creative industries tend to concentrate geographically, forming creative regions due to different factors. Soft factors seem to play a minor role at the European level, which have not been extensively studied. This paper examines this role and analyses whether regions with similar levels of other factors have higher concentrations of creative industries. A two-stage analysis is carried out. The first stage consists of a cluster analysis, to obtain groups of regions similar in other factors, and the second stage is the estimation of three econometric models that explain the concentration of creative industries by including a dummy variable for each group and soft factor variables. It is concluded that soft factors are relevant in explaining the concentration of creative industries by differentiating regions with similar levels in the remaining factors.

RESUMEN Las industrias creativas tienden a concentrarse geográficamente formando regiones creativas, proceso en que confluyen diferentes factores. Entre estos, los factores blandos parecen desempeñar un papel secundario en el ámbito europeo, por lo que no se han estudiado en profundidad. Este artículo aborda dicho papel, en particular si en las regiones con niveles similares de otros factores, los blandos permiten explicar las mayores concentraciones de industrias creativas. Con tal objetivo se lleva a cabo un análisis en dos etapas. La primera consiste en un análisis de clústeres, para obtener grupos de regiones similares en otros factores; y la segunda, en la estimación de tres modelos econométricos que explican la concentración de las industrias creativas mediante la inclusión de una variable ficticia para cada grupo, y variables de factores blandos. Las conclusiones muestran que los factores blandos son relevantes para explicar la concentración de industrias creativas, al diferenciar regiones con niveles similares en los otros factores.

Abstract This article proposes a critical approach to qualitative comparative methodologies in the study of social policies, based on the analysis of the case study presented by Mishra (1995) in his book ‘The Welfare State in Capitalist Society’. The aim is to answer the research question of this article: how, in qualitative research, do the choices of comparison units facilitate or limit the understanding of social policies? The methodology adopted involves theoretical, documentary, and case study analysis, examining common frames of reference in comparative approaches, such as causality, empirical variations, application limits, theorization, and comparison units. The study shows that the methodological path to understanding different realities is increasingly linked to the formation of comparative units and the definition of the nature of the cases, often classified as successful, unsuccessful, or hybrid experiences. These categories can result from a logical construct defined by the researcher. The conclusion is that one of the most relevant aspects of the research lies in the poor or non-existent grasp of the meanings and explanatory senses that each unit of analysis and comparative cases (political regimes) attribute to their choices in the face of the crises of capitalism. Ramesh Mishra's work reinforces our suspicion: in qualitative research, comparing cases can improve the understanding of social policies and limit their interpretation and explanation. Taking the conscious risk of comparing social policies as national agreements, with a high degree of territorial variation, is a practice that can ignore the specific logic and dynamics of each context. This review therefore emphasises the importance of a critical understanding of methodological choices and theoretical approaches in comparative qualitative studies. As well as recognizing that not everything is comparable and that replication can reinforce the coloniality of knowledge, it stresses the need to pay attention to the ‘hierarchy of credibility’ when analyzing comparative models.

Resumo Este artigo propõe uma abordagem crítica às metodologias comparativas qualitativas no estudo das políticas sociais, ancorando-se na análise do estudo de caso apresentado por Mishra (1995) no livro "O Estado-Providência na sociedade capitalista". O objetivo é responder à questão de investigação deste artigo: de que forma, nas pesquisas qualitativas, as escolhas das unidades de comparação facilitam ou limitam a compreensão das políticas sociais? A metodologia adotada envolve a análise teórica, documental e de estudo de caso, examinando quadros de referência comuns em abordagens comparativas, como a causalidade, variações empíricas, limites de aplicação, teorização e unidades de comparação. O estudo evidencia que a trajetória metodológica para compreender realidades distintas está cada vez mais vinculada à formação de unidades comparativas e à definição da natureza dos casos, frequentemente classificados como experiências de sucesso, fracasso ou híbridas, categorias que podem resultar de um constructo lógico definido pelo investigador. Conclui-se que um dos aspetos mais relevantes da investigação reside na fraca ou nula apreensão dos significados e sentidos explicativos que cada unidade de análise e/ou casos comparados (regimes políticos) atribui às suas escolhas face às crises do capitalismo. Assumir conscientemente o risco de comparar políticas sociais, com elevado grau de variação territorial, é uma prática que pode ignorar as lógicas e dinâmicas específicas de cada contexto. Por conseguinte, esta recensão destaca a importância de uma compreensão crítica das escolhas metodológicas e das abordagens teóricas em estudos qualitativos comparativos. Para além de reconhecer que nem tudo é comparável e que a replicação pode reforçar a colonialidade do conhecimento, sublinha-se a necessidade de atenção à "hierarquia da credibilidade" ao analisar modelos comparativos.

Abstract: A great diversity of living beings and human values are invisible to the prevailing global culture, which associates the word biodiversity with large organisms such as trees and mammals. Paradoxically, most biodiversity is made up of small organisms that remain invisible to global society and are under-represented in philosophy, science, and education. To help resolve this “biocultural blindness” about biological and value diversity, in this article we present concepts and practices of field environmental philosophy. We focus on the activity “ecotourism with a hand-lens” to illustrate “conceptual lenses” that amplify the appreciation of biological and cultural diversity. This activity integrates philosophy, sciences, and arts to appreciate the beauty and relevance of small organisms and the multiplicity of languages, forms of knowledge, and values that different cultural traditions give to biodiversity. Participants practice forms of analogical thinking to co-create knowledge and biocultural expressions of their own, instead of being passive recipients of information. Finally, this field environmental philosophy activity combines bodily and sensory activities with theoretical readings that provide conceptual foundations for cultivating a biocultural ethic that guides forms of co-inhabitation with small and large co-inhabitants (humans and others-than-humans) with whom we share both our local habitats and the global biosphere.

Resumen: Una gran diversidad de seres vivos y valores humanos son invisibles a la cultura global prevaleciente, que asocia la palabra biodiversidad con grandes organismos tales como mamíferos y árboles. Paradójicamente, la mayoría de la biodiversidad está compuesta por pequeños organismos que permanecen invisibles para la sociedad global y son subrepresentados en la filosofía, la ciencia y la educación. Para contribuir a resolver esta “ceguera biocultural” sobre la diversidad biológica y de valores, en este artículo presentamos conceptos y prácticas de la filosofía ambiental de campo. Nos enfocamos en la actividad “ecoturismo con lupa” para ilustrar “lentes conceptuales” que amplifican la apreciación de la diversidad biológica y cultural. Esta actividad integra las ciencias, artes, humanidades y ética para apreciar la belleza y relevancia de los pequeños organismos y los múltiples lenguajes, formas de conocimientos y valores que diferentes tradiciones culturales otorgan a la biodiversidad. Los participantes practican formas de pensamiento analógico para co-crear conocimiento y expresiones bioculturales propias, en vez de ser receptores pasivos de información. Finalmente, la práctica de la filosofía ambiental de campo combina actividades corporales y sensoriales con lecturas teóricas que proveen fundamentos conceptuales para cultivar una ética biocultural que orienta formas de co-habitación con pequeños y grandes co-habitantes, humanos y otros-que-humanos, con quienes compartirnos tanto nuestros hábitats locales como la biosfera global.

Resumen La moderna Sociedad del Conocimiento percibe una innovadora característica basada en manejar los contenidos curriculares, potenciando el pensamiento lógico matemático por medio de plataformas y aplicaciones digitales. El objetivo del presente trabajo se centraliza en analizar estrategias didácticas aplicadas por docentes para potenciar las habilidades matemáticas en los estudiantes del nivel de Bachillerato General Unificado dentro de la Unidad Educativa “Eidan Abel Erique Cercado” del cantón San Vicente. El aspecto metodológico se basó en el enfoque mixto, empleando como instrumento primordial una prueba pedagógica que mide las destrezas del pensamiento numérico, así como los indicios de una entrevista semi estructurada y los aportes de docentes del área de matemáticas como participantes dentro de un grupo focal. Se comprobó la predisposición para un trabajo orientado bajo la plataforma Khan Academy, necesaria para beneficiar las habilidades del pensamiento numérico poco perfeccionadas en el estudiante. Finalmente, se denotaron aquellas estrategias empleadas por los docentes las cuales no afirman una estimulación consistente para potenciar las habilidades numéricas, demostradas bajo un nivel poco aceptable en el afianzamiento de la resolución de problemas con enfoque matemático en los estudiantes.

Abstract The modern knowledge society perceives an innovative characteristic based on managing curricular contents, promoting mathematical logical thinking through digital platforms and applications, the purpose of this work is focused on determining the existing perception with the use of the Khan Academy platform in the mathematical skills and how teachers focus didactic strategies to enhance mathematical skills in students of the Unified General Baccalaureate level within the "Eidan Abel Erique Cercado" Educational Unit of the San Vicente canton. The methodological aspect was based on the paradigm of the mixed approach, using as a primary instrument a pedagogical test that measures the skills of numerical thinking, as well as the indications of a semi-structured interview and the contributions of teachers in the area of mathematics as participants within a focus group. The predisposition for a work oriented under the Khan Academy platform, necessary to benefit the slightly improved numerical thinking skills in the student, was verified. Finally, those strategies used by teachers were denoted which do not affirm a perennial stimulation to enhance numerical skills, demonstrated under an unacceptable level in the consolidation of problem solving with a mathematical approach in students.