RESUMEN Introducción: A lo largo de los años se ha propuesto una notable variedad de protocolos quirúrgicos periodontales, cuyo enfoque pasó de la simple resolución de defectos de tejidos blandos a la realización de procedimientos predecibles y mínimamente invasivos. Inicialmente se usaba el injerto gingival libre. Posteriormente se han probado diversas técnicas, incluidas aquellas con sustitutos de tejidos blandos, como membranas tipo Alloderm. Hoy en día se considera el gold standard el injerto de tejido conectivo subepitelial asociado al colgajo de avance coronal. Por último, se ha examinado la técnica Pinhole, con mayor preservación de tejido y resultado más estético. Objetivos: El objetivo de esta revisión fue la comparación de técnicas actualizadas para el tratamiento de recesiones múltiples en maxilar superior e inferior. El resultado del procedimiento se evaluó en términos de cobertura radicular completa, reducción de la recesión, ganancia en altura y volumen, resultado estético, dolor postoperatorio y morbilidad del lecho donante y receptor del paciente. Material y métodos: Se realizaron búsquedas electrónicas y manuales para recopilar estudios de boca dividida, ensayos clínicos controlados aleatorios, series de casos, estudios piloto, libros de periodoncia, estudios de casos, revisiones sistemáticas y metanálisis, incluyendo los defectos de recesiónes gingivales múltiples, en maxilar y mandibular, de las cuatro clases de Miller, debido a su extensa evidencia. Resultados: Se incluyeron treinta y cuatro publicaciones y se extrajeron datos sobre el resultado de las técnicas quirúrgicas de dieciocho artículos. La evaluación clínica analizó la cantidad de cobertura radicular completa, la reducción de la recesión y la ganancia de altura y volumen, mientras que la perspectiva del paciente se expresó en términos de satisfacción estética y posibles complicaciones postoperatorias. Los procedimientos de los últimos diez años mostraron mejores resultados en todos los factores mencionados anteriormente. Conclusión: La predictibilidad y la estabilidad del tratamiento a largo plazo representan los factores que guían el proceso de elección de la técnica y que añaden valor a los procedimientos más actualizados. Se observaron progresos tanto a nivel estético, al reducir las discrepancias entre el área intervenida y el tejido circundante, como a nivel postoperatorio, al aminorar las molestias del paciente. Los desafíos propios de esta rama pronto podrían encontrar respuesta gracias a su rápida evolución, la cual permite concebir más avances.

ABSTRACT Background: Along the years, a remarkable variety of periodontal surgical protocols has been proposed, the focus of which has shifted from the mere resolution of a soft tissue defect to the performance of predictable and minimally invasive procedures. Initially, the free gingival graft was used. Subsequently, many different techniques were experimented, including those using soft tissue substitutes, such as the Alloderm membrane. Nowadays, the association of the connective tissue graft with the coronally advanced flap is considered the gold standard. Finally, the Pinhole technique, being a more conservative method in terms of tissue preservation and aesthetic outcome, was proposed. Objectives: The aim of this review was the comparison of the updated techniques for the treatment of multiple periodontal recessions, affecting both maxilla and mandible. The procedure outcome was assessed in terms of complete root coverage, recession reduction, gain in height and volume, aesthetic outcome, patient’s post-operative pain and morbidity of donor and recipient sites. Material and methods: Electronic and hand searches were performed to collect split- mouth studies, randomized controlled clinical trials, case series, pilot studies, periodontal books, case studies, systematic reviews and meta-analysis, including maxillary and mandibular multiple gingival recession defects of all four Miller’s classes, for its extensive evidence. Results: Thirty-four publications were included and data regarding the surgical techniques outcome were extracted from eighteen articles. The clinical evaluation analyzed the amount of complete root coverage, recession reduction and gain in height and volume, while the patient’s perspective was expressed in terms of aesthetic satisfaction and possible postoperative complications. Procedures in the last ten years showed better results in all the above-mentioned factors. Conclusion: Procedural predictability and long-lasting treatment stability embody the factors driving the technique election process and adding value to more updated procedures. Progress was observed both at an aesthetic level, by reducing the discrepancias between the surgical region and the surrounding tissue, and at a postoperative level, by reducing patient discomfort. The challenges inherent to this branch could soon find answers thanks to its prompt evolution, which allows for further advances to be conceived.

In a time where approximately one-third of the world Spopulation identify as Christian, while the percentage of individuals rejecting the idea of a divine being remains relatively low, it is striking that proponents of the latter category attempt to silence research and findings from the former group. A recent example of this is the reaction to four articles published in 2023 in the Tydskrif vir Geesteswetenskappe (Journal of Humanities). These articles discuss recent scientific research, indicating highly intelligent and precise design in both macrocosm and microcosm, leading researchers to logically conclude that there must be a designer who cannot be a part of the cosmos itself. This conclusion causes significant discomfort among atheistically inclined thinkers, as evidenced by the fierce response to these articles. It appears that there is even pressure on academic journals to employ censorship and refrain from publishing such research. This article is a reaction to such criticism. Spangenberg (2023) takes issue with the assumption of the researchers of the four articles that humans are rational beings, by emphasising the irrationality of certain human behaviour. He has a significant problem with the researchers' suggestion that the order found in nature and humans' rational thinking abilities cannot be seen as coincidental but are ordained by God. He also attempts to create a contradiction between a merciful God and a God who punishes sin. But all these arguments can be dismissed based on basic logic. Spangenberg accuses the authors of misinformation when discussing Genesis. Referring to Genesis 1:26, he asserts that when God says, "let us make man," it implies multiple gods. Spangenberg's idea of polytheism in Genesis is further emphasised by his reference to the garden in Genesis 2 as the garden of gods, because it was located in the east. According to him, that would have referred to the place where heaven and earth meet, allowing gods residing in heaven to enter the earth. This conclusion based on the garden's eastern location resembles a slippery slope form of reasoning. Even when considering only the Pentateuch, the introduction of the so-called assembly of gods and garden of gods in Genesis 1 and 2 by Spangenberg cannot be considered a plausible interpretation. The focus in the Pentateuch, as in the rest of the Bible, is on the fact that God must be known and acknowledged as the only God, contrary to the pagan nations' concept of multiple gods. Spangenberg based his ideas on the documentary hypothesis - a theory that claims that the first five books of the Bible emerged over a long period of time and that they are a compilation of various and contradictory documents. He uses this to discredit the research in the four articles, despite the fact that even supporters of the documentary hypothesis admit to problems in this hypothesis. Contemporary research suggests that it is crucial to consider the truth claims of the Pentateuch itself and move away from hypothetical source documents. Arguments by people such as Spangenberg, that authors who do not accept this document hypothesis or give reference to it should be censured, cannot bear any weight. In fact, recent research returns to the idea that the Pentateuch is a single work, written according to a plan and largely composed by one author. By accepting its unity and inspiration, as millions of Christians do, valuable insights can be gained, for instance by considering why specific names for God are used in particular contexts. Conversely, viewing it as merely different sources does not yield fruitful research. In a further attempt to discredit the four scientific articles in the TGW, Spangenberg points to the negative way in which the church had supposedly dealt with Galileo Galilei's heliocentric research some centuries ago. Contrary to Spangenberg's assertion, the reality is that Galileo's affair did not start as a conflict between science and the church. The church had initially encouraged Galileo to continue his work. It was particularly natural scientists who, partly justifiable and partly not, raised issues concerning the results of his research. As evidenced by the authors of the four articles mentioned above, it was especially Christian thinkers who had developed scientific knowledge throughout many centuries; moreover, they had established and funded several universities where research could be done. Upon examining the four articles opposed by Spangenberg and others, it becomes clear how crucial it is that science and its results should not be suppressed. The articles discuss research in natural sciences and cosmology that delves into the cause and fine-tuning of the universe, as well as the precision of cosmic constants that make life possible. Additionally, they explore the origins of encoded information within DNA, and its role in life itself. It is unacceptable to reject experimental observations and derived theories based on a negative view of Christian beliefs beforehand. Scientific inquiry necessitates an unbiased and open-minded approach, demonstrating the courage to interpret data honestly, in order to reach the most probable conclusion.

Dit klink ongehoord om sensuur op artikels te wil toepas, wanneer dié artikels op grond van natuurwetenskaplike navorsing aandui dat die bevindinge in ooreenstemming is met dit wat 'n groot deel van die wereldbevolking glo. Tog is 'n onlangse voorbeeld hiervan die reaksie op vier artikels wat in 2023 in die Tydskrif vir Geesteswetenskappe (TGW) gepubliseer is. In hierdie artikels is die resultaat van natuurwetenskaplike en kosmologiese navorsing wat op 'n hoogs intelligente en presiese ontwerp in beide makro- en mikrokosmos dui, bespreek. Die navorsingsresultate dui daarop dat daar 'n intelligente ontwerper van die kosmos moet wees. In sy reaksie op die vier artikels, erken Spangenberg die geldigheid van die navorsings-resultate, maar hy voer aan dat dit nie met die eerste vyf boeke van die Bybel vergelyk kan word nie, aangesien laasgenoemde nie betroubaar is nie. Gegrond op sy ewolusionistiese siening van godsdiens, beweer hy dat die Pentateug as 'n bloot menslike samestelling van verskeie en teenstrydige dokumente ontstaan het. Resente Bybelwetenskaplike navorsing dui egter heelwat probleme met hierdie bronnehipotese aan, met die gevolg dat navorsers terugkeer na die siening dat die Pentateug grootliks deur een outeur saamgestel is, 'n geheel vorm en as sodanig betroubaar is. Anders as wat Spangenberg met sy verwysing na Galileo beweer, staan die Christendom nie in die pad van goeie navorsing nie. Christen-denkers het deur die eeue heen kosbare wetenskaplike werk gedoen en boonop verskeie universiteite gestig en befonds. Wetenskaplike ondersoek vereis 'n onbevooroordeelde benadering, wat die geleentheid skep dat bevindinge eerlik geïnterpreteer kan word om tot die mees waarskynlike gevolgtrekkings te lei. In 'n era waar rofweg 'n derde van die mensdom hulleself as Christene beskou (Dyvik, 2023), terwyl die persentasie mense wat ateïsties die idee van 'n goddelike wese verwerp wêreldwyd baie laag is, is dit opvallend dat voorstanders van laasgenoemde kategorie, navorsers en navorsing uit eersgenoemde groepering probeer stilmaak. 'n Resente voorbeeld hiervan is die reaksie op vier artikels wat in 2023 in die Tydskrif vir Geesteswetenskappe (TGW) verskyn het. In hierdie artikels (Dreyer, Van der Walt & Denton, 2023; Dreyer & Van der Walt, 2023a, 2023b, 2023c) bespreek die skrywers nuwere wetenskaplike ontdekkings en hoe die ontdek-kings aanduiding van hoogs-intelligente en presiese ontwerp gee.

RESUMEN Introducción: A lo largo de los años se ha propuesto una notable variedad de protocolos quirúrgicos periodontales, cuyo enfoque pasó de la simple resolución de defectos de tejidos blandos a la realización de procedimientos predecibles y mínimamente invasivos. Inicialmente se usaba el injerto gingival libre. Posteriormente se han probado diversas técnicas, incluidas aquellas con sustitutos de tejidos blandos, como membranas tipo Alloderm. Hoy en día se considera el gold standard el injerto de tejido conectivo subepitelial asociado al colgajo de avance coronal. Por último, se ha examinado la técnica Pinhole, con mayor preservación de tejido y resultado más estético. Objetivos: El objetivo de esta revisión fue la comparación de técnicas actualizadas para el tratamiento de recesiones múltiples en maxilar superior e inferior. El resultado del procedimiento se evaluó en términos de cobertura radicular completa, reducción de la recesión, ganancia en altura y volumen, resultado estético, dolor postoperatorio y morbilidad del lecho donante y receptor del paciente. Material y métodos: Se realizaron búsquedas electrónicas y manuales para recopilar estudios de boca dividida, ensayos clínicos controlados aleatorios, series de casos, estudios piloto, libros de periodoncia, estudios de casos, revisiones sistemáticas y metanálisis, incluyendo los defectos de recesiónes gingivales múltiples, en maxilar y mandibular, de las cuatro clases de Miller, debido a su extensa evidencia. Resultados: Se incluyeron treinta y cuatro publicaciones y se extrajeron datos sobre el resultado de las técnicas quirúrgicas de dieciocho artículos. La evaluación clínica analizó la cantidad de cobertura radicular completa, la reducción de la recesión y la ganancia de altura y volumen, mientras que la perspectiva del paciente se expresó en términos de satisfacción estética y posibles complicaciones postoperatorias. Los procedimientos de los últimos diez años mostraron mejores resultados en todos los factores mencionados anteriormente. Conclusión: La predictibilidad y la estabilidad del tratamiento a largo plazo representan los factores que guían el proceso de elección de la técnica y que añaden valor a los procedimientos más actualizados. Se observaron progresos tanto a nivel estético, al reducir las discrepancias entre el área intervenida y el tejido circundante, como a nivel postoperatorio, al aminorar las molestias del paciente. Los desafíos propios de esta rama pronto podrían encontrar respuesta gracias a su rápida evolución, la cual permite concebir más avances.

ABSTRACT Background: Along the years, a remarkable variety of periodontal surgical protocols has been proposed, the focus of which has shifted from the mere resolution of a soft tissue defect to the performance of predictable and minimally invasive procedures. Initially, the free gingival graft was used. Subsequently, many different techniques were experimented, including those using soft tissue substitutes, such as the Alloderm membrane. Nowadays, the association of the connective tissue graft with the coronally advanced flap is considered the gold standard. Finally, the Pinhole technique, being a more conservative method in terms of tissue preservation and aesthetic outcome, was proposed. Objectives: The aim of this review was the comparison of the updated techniques for the treatment of multiple periodontal recessions, affecting both maxilla and mandible. The procedure outcome was assessed in terms of complete root coverage, recession reduction, gain in height and volume, aesthetic outcome, patient’s post-operative pain and morbidity of donor and recipient sites. Material and methods: Electronic and hand searches were performed to collect split- mouth studies, randomized controlled clinical trials, case series, pilot studies, periodontal books, case studies, systematic reviews and meta-analysis, including maxillary and mandibular multiple gingival recession defects of all four Miller’s classes, for its extensive evidence. Results: Thirty-four publications were included and data regarding the surgical techniques outcome were extracted from eighteen articles. The clinical evaluation analyzed the amount of complete root coverage, recession reduction and gain in height and volume, while the patient’s perspective was expressed in terms of aesthetic satisfaction and possible postoperative complications. Procedures in the last ten years showed better results in all the above-mentioned factors. Conclusion: Procedural predictability and long-lasting treatment stability embody the factors driving the technique election process and adding value to more updated procedures. Progress was observed both at an aesthetic level, by reducing the discrepancias between the surgical region and the surrounding tissue, and at a postoperative level, by reducing patient discomfort. The challenges inherent to this branch could soon find answers thanks to its prompt evolution, which allows for further advances to be conceived.

Abstract Purpose: This article aims to incorporate scholarly work on autoethno-graphy into applied social sciences to solidify the knowledge that steers research methodology in the business and management field. Originality/value: In the sphere of social sciences, researchers are distinguished by their comprehensive practical acumen and adeptness at deciphering complex phenomena, bringing an array of insights to the dis-cipline that enriches surface-level understanding. However, due to the persistent sway of the functionalist paradigm, these insights are often disregarded in favor of traditional methodologies, thereby bypassing opportunities for advancement. The research methodology of autoethnography, characterized by distinctive elements diverging from conventional ethnographic methods, presents a promising avenue to harness these overlooked potentials. Despite its recent emergence in ethnographic discourse, the under-recognition and fragmentation of scholarly work on autoethnography within management research constitute a challenge that warrants attention. Design/methodology/approach: A systematic literature review was employed, consisting of books, book chapters, and peer-reviewed journal articles, to scrutinize both the theoretical underpinnings and practical applications of autoethnography, particularly within the domain of social sciences. Findings: This study illuminates the intricacies of employing autoethnography within management research. This article explores the method’s relevance, potentialities, and challenges, providing practical solutions to enhance its rigor and appeal. By synthesizing and integrating four main categories of autoethnography, this study contributes to the methodology in management studies. Case examples further enrich this discourse by highlighting the effective use of autoethnography in real-world scenarios. The product is a systematic and practical insight into harnessing the power of autoethnography for profound management research. Purpose autoethno graphy field Originality/value Originalityvalue Originality value phenomena discipline dis cipline surfacelevel surface level understanding However paradigm methodologies advancement methods potentials underrecognition under recognition attention Design/methodology/approach Designmethodologyapproach Design approach employed books chapters peerreviewed peer reviewed articles Findings method s relevance potentialities challenges appeal studies realworld real world scenarios

Resumo Objetivo: Este artigo objetiva incorporar o trabalho acadêmico sobre autoetnografia nas ciências sociais aplicadas para consolidar o conhecimen-to que orienta a metodologia de pesquisa no campo da administração. Originalidade/valor: Na esfera das ciências sociais, os pesquisadores se distinguem por sua perspicácia prática abrangente e habilidade em decifrar fenômenos complexos, trazendo uma série de percepções para o campo que enriquece a compreensão em nível superficial. No entanto, devido à influência persistente do paradigma funcionalista, esses insights são muitas vezes desconsiderados em favor de metodologias tradicionais, ignorando assim as oportunidades de avanço. A autoetnografia, caracterizada por elementos distintos que divergem dos métodos etnográficos convencionais, apresenta um caminho promissor para aproveitar esses potenciais negligenciados. Apesar de seu recente surgimento no discurso etnográfico, o pouco reconhecimento e a fragmentação do trabalho acadêmico sobre autoetnografia na pesquisa em administração constituem um desafio que merece atenção. Design/metodologia/abordagem: Realizamos uma revisão sistemática da produção acadêmica, abrangendo livros, capítulos de livros e artigos de periódicos revisados por pares, para examinar tanto os fundamentos teóricos quanto as aplicações práticas da autoetnografia, particularmente no campo das ciências sociais. Resultados: Este estudo esclarece as complexidades do emprego da auto-etnografia na pesquisa em administração. Este artigo explora a relevância, as potencialidades e os desafios do método etnográfico, fornecendo soluções práticas para aumentar seu rigor e apelo. Ao sintetizar e integrar quatro categorias principais de autoetnografia, este artigo contribui para a metodologia em administração. Os exemplos de casos enriquecem ainda mais esse discurso, destacando o uso eficaz da autoetnografia em cenários do mundo prático. O produto é uma visão sistematizada e prática do aproveitamento do poder da autoetnografia para uma pesquisa profunda em administração. Objetivo conhecimento conhecimen to Originalidade/valor Originalidadevalor Originalidade valor complexos superficial entanto funcionalista tradicionais avanço convencionais negligenciados etnográfico atenção Design/metodologia/abordagem Designmetodologiaabordagem Design abordagem acadêmica pares Resultados auto etnografia relevância apelo prático

Abstract The book Imágenes, representaciones y movilizaciones indígenas en Latinoamérica [which could translate as Indigenous Images, Representations, and Mobilizations in Latin America] coordinated by Silvia Soriano Hernández, is an invitation to analyze different problems faced by the emerging situation in Latin America and the Caribbean. It is based on four thematic pillars: Perspectives and Different Forms of Resistance, Disputes and Emergencies, Dialogues and Racial Intermarriage, as well as Racism and Interculturality. The book’s chapters reflect the issues, imaginaries, anti-racist struggles, history, and representations of social movements in different regions of Latin America and the Caribbean. This review concludes that the book’s contributions illustrate multiple approaches to socio-anthropological knowledge in which science that has hitherto been sponsored by rapacious imperialism is undergoing changes through reclaiming different epistemologies.

Resumen El libro Imágenes, representaciones y movilizaciones indígenas en Latinoamérica, coordinado por Silvia Soriano Hernández, nos invita a analizar diferentes problemáticas de la situación emergente de América Latina y el Caribe a partir de cuatro ejes: miradas y resistencias, disputas y emergencias, diálogos y mestizajes, y racismos e interculturalidad. En sus capítulos se reflejan problemáticas, imaginarios, luchas antirracistas, historia y representaciones a partir de movimientos sociales en diferentes regiones del continente. Se concluye que las contribuciones del libro ejemplifican los múltiples abordajes del conocimiento socioantropológico, en los que la ciencia, hasta ahora patrocinada por un imperialismo rapaz. está experimentando cambios a partir de la reivindicación de diferentes epistemologías.

RESUMEN Objetivos: construir y evaluar una tecnología educativa para la gestión de listas de espera de pacientes para formación multidisciplinaria. Métodos: estudio apoyado en Diseño Instruccional - modelo ADDIE, cuyas etapas de construcción de tecnología educativa se desarrollaron en forma de curso de formación multiprofesional. Su respectiva evaluación de contenidos fue realizada por un comité de expertos del 2021 al 2022. El análisis se realizó utilizando la proporción de adecuación del contenido con un Intervalo de Confianza del 95%. Resultados: se crearon 17 productos como objetos de aprendizaje de tecnología educativa: cinco storyboards; cuatro vídeos; tres cómics; dos planes de acción pedagógicos; un mapa mental; y una lista de reproducción de YouTube®. Nueve expertos evaluaron la adecuación de los contenidos, que alcanzó un 0,89. Conclusiones: esta tecnología educativa contribuye al desempeño de los profesionales que gestionan las listas de espera, reduciendo las desigualdades, aliviando las diferencias, además de promover la equidad en la atención y la buena salud de los pacientes del Sistema de Salud Brasileño. Objetivos multidisciplinaria Métodos ADDIE multiprofesional 202 2022 95 95% Resultados 1 storyboards vídeos cómics pedagógicos mental YouTube YouTube® 089 0 89 0,89 Conclusiones desigualdades diferencias Brasileño 20 9 08 8 0,8 2 0,

RESUMO Objetivos: construir e avaliar uma tecnologia educativa de gerenciamento de listas de espera de pacientes para a formação multiprofissional. Métodos: estudo sustentado pelo Design Instrucional - modelo ADDIE, cujas etapas de construção da tecnologia educativa foram desenvolvidas na modalidade de curso de formação multiprofissional. Sua respectiva avaliação de conteúdo foi realizada por um comitê de especialistas de 2021 a 2022. A análise ocorreu pela proporção de adequação de conteúdo com Intervalo de Confiança de 95%. Resultados: elaboraram-se 17 produtos como objetos de aprendizagem da tecnologia educativa: cinco storyboards; quatro vídeos; três histórias em quadrinhos; dois planos de ação pedagógica; um mapa mental; e uma playlist do YouTube®. Nove especialistas avaliaram adequação de conteúdo, que atingiu 0,89. Conclusões: essa tecnologia educativa contribui na atuação dos profissionais que gerenciam listas de espera ao reduzir desigualdades, amenizar diferenças, além de promover equidade no atendimento e boa saúde ao paciente no Sistema Único de Saúde. Objetivos multiprofissional Métodos ADDIE 202 2022 95 95% Resultados elaboraramse elaboraram se 1 storyboards vídeos quadrinhos pedagógica mental YouTube YouTube® 089 0 89 0,89 Conclusões desigualdades diferenças Saúde 20 9 08 8 0,8 2 0,

ABSTRACT Objectives: to construct and assess an educational technology for managing patient waiting lists for multidisciplinary training. Methods: study supported by Instructional Design - ADDIE model, whose stages of construction of educational technology were developed in the form of a multi-professional training course. Its respective content assessment was carried out by a committee of experts from 2021 to 2022. The analysis occurred based on the proportion of content adequacy with 95% Confidence Interval. Results: seventeen products were created as educational technology learning objects: five storyboards; four videos; three comic books; two pedagogical action plans; a mind map; and a YouTube® playlist. Nine experts assessed content adequacy, which reached 0.89. Conclusions: this educational technology contributes to the performance of professionals who manage waiting lists by reducing inequalities, alleviating differences, in addition to promoting equity in care and good health for patients in the Brazilian Health System. Objectives Methods model multiprofessional multi professional course 202 2022 95 Interval Results objects storyboards videos books plans map YouTube playlist 089 0 89 0.89 Conclusions inequalities differences System 20 9 08 8 0.8 2 0.

ABSTRACT Objective: The study aimed to propose a metadata model for representing audiobooks. Specifically, we sought to: a) identify existing metadata standards in the literature; b) identify specific elements of audiobooks; c) compare metadata standards and d) map elements to represent audiobooks. Method: The research was characterized as descriptive, exploratory and applied, using bibliographic and documentary research, being divided into three stages. Initially, bibliographical research was carried out to identify metadata standards in the literature. Next, specific elements for audiobooks and their concepts were identified. Finally, the aspects for representing audiobooks were listed and associated with metadata standards that were analyzed and compared to propose a model. All stages were carried out in the second half of 2023. Result: Four metadata categories for audiobooks were established: essential information; additional information; content and classification information and technical information. The identified metadata includes metadata standard to other book supports such as: title, author, narrator, summary, subject, rating, genre and audiobook-specific metadata such as: narrator, edition, duration, among others, present in different selected metadata patterns for analysis: Dublin Core, ID3, IFLA LRM, MARC and MPEG-7. Conclusions: The creation of unique metadata for audiobooks is not just a suggestion, but a necessity. It is crucial for providing a distinct description of the resource, thereby facilitating its identification and retrieval by users. The comparative analysis of metadata standards has allowed us to identify essential elements that adequately represent audiobooks, considering their unique characteristics and the commonalities they share with physical books and audios. Objective Specifically literature b c d Method descriptive applied Initially Next Finally 2023 Result established title author narrator summary subject rating audiobookspecific audiobook edition duration others Core ID3 ID LRM MPEG7. MPEG7 MPEG 7. 7 MPEG-7 Conclusions suggestion necessity resource users audios 202 MPEG- 20 2

RESUMO Objetivo: O estudo teve como objetivo propor um modelo de metadados para representação de audiolivros. Especificamente buscou-se: a) identificar os padrões de metadados existentes na literatura; b) identificar elementos específicos dos audiolivros; c) comparar os padrões de metadados e d) mapear os elementos para representação dos audiolivros. Método: A pesquisa foi caracterizada como descritiva, exploratória e aplicada, utilizando a pesquisa bibliográfica e documental, sendo dividida em três etapas. Inicialmente foi realizada uma pesquisa bibliográfica para identificação dos padrões de metadados na literatura. Em seguida, foram identificados elementos específicos para os audiolivros e seus conceitos. Por fim, os elementos para representação dos audiolivros foram listados e associados aos padrões de metadados que foram analisados e comparados para proposição de um modelo. Todas as etapas foram realizadas no segundo semestre de 2023. Resultado: Foram estabelecidas quatro categorias de metadados para audiolivros: informações essenciais; informações complementares; informações de conteúdo e classificação e informações técnicas. Os metadados identificados incluem metadados comuns a outros suportes do livro como: título, autor, narrador, resumo, assunto, classificação indicativa, gênero; e metadados específicos do audiolivro como: narrador, edição, duração, entre outros presentes em diferentes padrões de metadados selecionados para análise: Dublin Core, ID3, IFLA LRM, MARC e MPEG-7. Conclusões: A criação de metadados específicos para audiolivros é essencial para proporcionar uma descrição única do recurso, facilitando sua identificação e recuperação pelos usuários. A análise comparativa dos padrões de metadados permitiu identificar elementos essenciais para representar adequadamente os audiolivros, considerando as particularidades e características comuns aos livros e áudios. Objetivo buscouse buscou se buscou-se literatura b c d Método descritiva aplicada documental seguida conceitos fim 2023 Resultado complementares técnicas título autor narrador resumo assunto indicativa gênero edição duração Core ID3 ID LRM MPEG7. MPEG7 MPEG 7. 7 MPEG-7 Conclusões recurso usuários áudios 202 MPEG- 20 2

Abstract In this article, a systematic review study was carried out based on the analysis of 47 productions resulting from state-of-the-art research, selected from a universe of 113 review studies produced in the period from 2000 to 2016: articles published in national journals of the area of education, registered in SciELO; books and the Inep’s Estado do Conhecimento Series. The objective of the article was to analyze the theoreticalmethodological characteristics of the research, identify the challenges to its realization and indicate trends, potentialities and challenges to metaknowledge in the field of education. As a result, it can be stated that there is a common basic repertoire on the methodological design of states of the art shared by researchers, but it is still necessary to advance in establishing criteria that are fundamental to the development of these studies, which can be systematized into four main challenges: greater dialogue with the literature on review studies; creation of networks of researchers; advance in the complete reading of the works or read parts that may bring relevant information about the characteristics of the research, such as introduction, methodology and conclusions; improve and increase research that maps, evaluates and produces syntheses to guide researchers and their commitment to science and social demands. 4 stateoftheart state 11 200 2016 education SciELO Ineps Inep s Series trends result introduction conclusions maps demands 1 20 201 2

Resumo Neste artigo foi realizado um estudo de revisão sistemática com base na análise de 47 produções resultantes de pesquisas do tipo “estado da arte”, selecionadas de um universo de 113 estudos de revisão produzidos no período de 2000 a 2016. Foram coletados artigos publicados em revistas nacionais da área de educação, registradas na Scielo; livros e a série Estado do conhecimento do INEP. O objetivo do artigo foi analisar as características teóricometodológicas das pesquisas, identificar os desafios a sua realização e indicar tendências, potencialidades e desafios ao metaconhecimento na área de educação. Como resultado, pode-se afirmar que existe um repertório básico comum sobre o desenho metodológico de “estados da arte” compartilhado pelos pesquisadores, mas ainda é necessário avançar no estabelecimento de critérios que são fundamentais ao desenvolvimento destes estudos, que podem ser sistematizados em quatro desafios principais: maior diálogo com a literatura sobre estudos de revisão; constituição de redes de pesquisadores; avançar na leitura completa dos trabalhos ou ler partes que possam trazer informações relevantes sobre as características da pesquisa, tais como, introdução, metodologia e conclusões; aprimorar e aumentar o número de pesquisas que mapeiem, avaliem e produzam sínteses para orientar os pesquisadores em seu compromisso com a ciência e as demandas sociais. 4 estado arte, arte , 11 200 2016 educação Scielo INEP tendências resultado podese pode se estados principais pesquisa como introdução conclusões mapeiem sociais 1 20 201 2

Resumen Esta investigación realiza un estudio de caso de la empresa de construcción pesada Odebrecht para responder a la pregunta: ¿Cómo un individuo racionaliza el crimen en una organización corrupta? Este estudio se basa en los conceptos de organización corrupta, continuo de destructividad, desvinculación moral y racionalización. Analizamos cuatro libros que son artefactos de la cultura Odebrecht y videos de 49 ejecutivos que colaboraron en la investigación “Lava Jato”. Los resultados describen los caminos que toman los empleados dentro de la organización, adquiriendo sus sistemas de valores, creencias y suposiciones. Estos caminos conducen a la racionalización de la corrupción. Este estudio de caso muestra que el continuo de destructividad comienza cuando los empleados encuentran un comportamiento poco ético dentro de la organización y que los mecanismos de racionalización cambian con el tiempo dentro de la cultura corrupta. Los ejecutivos pueden renunciar o denunciar en cualquier momento, sin embargo, con el tiempo se vuelve difícil ejercer cualquiera de estas opciones. Al aplicar y refinar el continuo, esta investigación proporciona una idea de cómo la desconexión moral y la racionalización alientan a los empleados a ascender en el continuo. pregunta Cómo corrupta 4 Lava Jato. Jato . Jato” valores suposiciones corrupción momento embargo opciones

Abstract This research conducts a case study on Odebrecht, a heavy construction company, to answer the question of how an individual rationalizes crime in a corrupt organization? The study is based on the concepts of a corrupt organization, the continuum of destructiveness, moral disengagement, and rationalization. We analyze four books, artifacts on Odebrecht’s culture and videos on 49 executives that collaborated in the Car Wash corruption probe. The results describe the paths employees undertake in the organization by acquiring its internal set of values, beliefs, and assumptions. These paths lead to the rationalization of corruption. This case study shows that the continuum of destructiveness starts when employees encounter unethical behavior in the organization and that their rationalization mechanism changes with time in the corrupt culture. At any point, executives can quit or blow the whistle; however, with time, it becomes more challenging to exercise either of the options. By applying and refining the continuum, this research provides an understanding of how moral disengagement and rationalization to help employees to progress in the continuum in a corrupt culture. Odebrecht company books Odebrechts s 4 probe values beliefs assumptions point whistle however options

Resumo Esta pesquisa conduz um estudo de caso de uma empresa de construção pesada Odebrecht para responder à questão: Como um indivíduo racionaliza o crime em uma organização corrupta? Este estudo é baseado nos conceitos de organização corrupta, contínuo da destrutividade, desengajamento moral e racionalização. Nós analisamos quatro livros que são artefatos da cultura da Odebrecht e vídeos de 49 executivos que colaboraram na investigação da Lava Jato. Os resultados descrevem os caminhos que os funcionários trilham dentro da organização, adquirindo seus sistemas de valores, crenças e pressupostos. Estes caminhos levam a racionalização da corrupção. Este estudo de caso mostra que o contínuo da destrutividade começa quando empregados encontram comportamentos antiéticos dentro da organização e que os mecanismos de racionalização se modificam com o tempo dentro da cultura corrupta. A qualquer momento executivos podem pedir demissão ou denunciar; no entanto, com o tempo se torna difícil exercer qualquer uma dessas opções. Ao aplicar e refinar o contínuo, esta pesquisa prove um entendimento sobre como desengajamento moral e racionalização incentivam funcionários a seguir adiante no contínuo. questão corrupta 4 Jato valores pressupostos corrupção denunciar entanto opções

Resumen La ciudad de Morelia es la capital del estado de Michoacán de Ocampo (México) y su centro histórico cuenta con una declaratoria de zona de monumentos históricos, ésta fue publicada el 19 de diciembre de 1990. El 12 de diciembre de 1991 fue inscrita como patrimonio cultural de la Humanidad por la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO). Entre las características de su centro histórico destaca la uniformidad de roca ignimbrítica color rosa, usada como material constructivo recubierto y sillares. Sin embargo, el problema de humedad por ascenso capilar afecta considerablemente a los inmuebles del Centro Histórico a través de dos factores principales: 1) la porosidad de la roca, que promedia los ~10 µm y tiene una conectividad del orden de 80 % y 2) niveles freáticos someros con una alta tasa de recarga acentuada durante el periodo de lluvias (mayo a junio). Entre las características de esta importante ciudad colonial se cuenta el resguardo común de acervos documentales y bibliotecas tanto públicas como particulares. Uno de ellos es el archivo de la Sección de Monumentos Históricos del Centro INAH Michoacán, integrado desde hace más de cuatro décadas y que concentra sistemáticamente los datos constructivos e intervenciones en inmuebles del siglo XVI al XIX de todo el estado. Este acervo ocupa un espacio específico en la planta baja del inmueble conocido como Palacio Federal de Morelia, donde la humedad por ascenso capilar es intensa. Para intentar minimizar o desaparecer la humedad que ponía en riego este importante acervo, se aplicó una metodología con materiales naturales, donde el uso de piedra pómez hizo eficiente el proceso de resguardo del acervo. Luego de una serie de pruebas, se observó que la piedra pómez P-HU muestra valores de densidad real ((r) en el rango de las rocas de composición riolítica, sin embargo, su densidad aparente (ρb) se encuentra en un rango < 1g/cm3, menor a la densidad del agua y directamente relacionada con su alta porosidad. Asimismo, la interconectividad entre poros es del orden de 70 %, donde se resalta que la dinámica hídrica de la pómez está relacionada y acotada únicamente por la porosidad accesible al agua. Con base en los resultados generales, las propiedades hídricas están vinculadas estrechamente con la distribución, el tamaño e interconexión de los poros de la pómez. En la práctica, el material en cuestión es altamente eficiente y permite proyectarlo como una opción confiable para la captura de humedad en espacios donde, particularmente, se resguardan libros o documentos de valor cultural o histórico; sin que sea la única aplicación de este material con posibilidades de éxito.

Abstract The city of Morelia is the capital of the state of Michoacán de Ocampo (Mexico) and its historic center has a declaration of zone of historical monuments, published on December 19, 1990. On 12 December 1991 it was registered as a World Heritage Site by the United Nations Educational, Scientific and Cultural Organization (UNESCO). Among the characteristics of its historic center stands out the uniformity of pink ignimbrite rock, used as a construction material and ashlars. However, the problem of humidity due to capillary ascent considerably affects the buildings of the Historic Center through two main factors: 1) the porosity of the rock, which averages ~10 μm and has a connectivity of the order of 80 % and, 2) shallow water tables with a high rate of recharge accentuated during the rainy period (May to June). Among the characteristics of this important colonial city, there is the common protection of documentary collections and libraries both public and private. One of them is the archive of the Section of Historical Monuments of the Centro INAH Michoacán, integrated for more than four decades, which systematically concentrates the construction data and interventions in buildings from the sixteenth to the nineteenth century throughout the state. This collection occupies a specific space on the ground floor of the building known as the Palacio Federal de Morelia, where the humidity due to capillary ascent is intense. To try to minimize or disappear the humidity that put this important collection at risk, a methodology was applied with natural materials, where the use of pumice stone made the process of safeguarding the collection efficient. After a series of tests, it was observed that the P-HU pumice stone shows values of real density (ρr) in the range of rhyolitic composition rocks, however, its apparent density (ρb) is in a range < 1g/cm3, less than the density of water and directly related to its high porosity. Likewise, the interconnectivity between pores is 70 %, where it is highlighted that the water dynamics of the pumice stone is related and bounded only by the porosity accessible to water. Based on the overall results, water properties are closely linked to the distribution, size and interconnection of pumice pores. In practice, the material in question is highly efficient and allows it to be projected as a reliable option for moisture capture in spaces where, in particular, books or documents of cultural or historical value are protected; without it being the only application of this material with a chance of success.

Resumen: Este trabajo muestra los resultados de investigación sobre el análisis de los textos científicos en torno a la figura femenina mexicana y campesina. La investigación se realizó con el método dialéctico-crítico que permite observar el problema de manera totalizante para así llegar a comprender la lógica con la que se desenvuelve. Para ello se llevó a cabo la lectura y análisis de obras y documentos relevantes en la temática. Se establecieron cuatro elementos para su selección: 1. Que abarcarán el periodo de la Colonia hasta los producidos en la actualidad; 2. Textos construidos desde los resultados de investigación; 3. Independientemente de la nacionalidad del autor, enfocados en el campo mexicano y; 4. Libros sin importar su fecha de publicación y los artículos con no más de tres años de edición. La economía campesina mexicana ha descansado en las y los actores de la unidad familiar: mujer y hombre, sean estos infantes, adultas o adultos. Aunque ya se ha transitado a otras formas de actividades económicas siguen siendo las mujeres fundamentales para esa unidad doméstica, como significativa para el desarrollo de sus comunidades la acción participativa de ellas. Aunque el discurso científico da cuenta de lo mencionado, no esclarece aún el significado del trabajo en el campo dependiente del género y de todas las desigualdades que éste sigue reproduciendo. Aunado a ello, la perspectiva de género en los textos científicos sigue siendo en su mayoría un asunto pendiente. Ante esto se visibiliza la deuda científica hacia los estudios de la mujer en uno de sus papeles más vulnerables: la de ser campesina.

Abstract: This work shows the results of research on the analysis of scientific texts around the Mexican and peasant female figure. The research was carried out with the dialectical- critical method that allows to observe the problem in a totalizing way to understand the logic with which it develops. To this end, the reading and analysis of relevant works and documents on the subject was carried out. Four elements were established for its selection: 1.That will cover the period of the Colony to those produced today; 2. Texts constructed from research results; 3. Regardless of the nationality of the author, focused on the Mexican countryside and 4. Books regardless of their date of publication and articles with no more than three years of edition. The Mexican peasant economy has rested on the actors of the family unit: woman and man, whether these are infants or adults. Although other forms of economic activities have already been transitioned, women are still fundamental to this domestic unit, as significant for the development of their communities the participatory action of them. Although the scientific discourse gives an account of the above, it does not yet clarify the meaning of work in the field dependent on gender and all the inequalities that it continues to reproduce. In addition, the gender perspective in scientific texts remains for the most part an unfinished business. Given this, the scientific debt towards women's studies is made visible in one of their most vulnerable roles: that of being a woman peasant.

Resumen El Nuevo Realismo Jurídico (NRJ) es una perspectiva teórica que promueve una relación colaborativa entre el derecho y las ciencias sociales. Esta teoría amplía el horizonte de los estudios legales al situar las problemáticas jurídicas en sus contextos sociales más amplios y asegurar un estudio científico del derecho. Este artículo reflexiona sobre la utilidad de adoptar el NRJ en los estudios legales sobre la implementación del derecho y, especialmente, el derecho internacional. A partir de una revisión de literatura, se discuten cuatro características del NRJ: carácter centrado en las normas jurídicas; promoción de la investigación interdisciplinaria; promoción de la investigación empírica; y promoción de la investigación activa y crítica en el derecho. Este artículo concluye que adoptar la perspectiva del NRJ en los estudios sobre la implementación del derecho internacional es importante para analizar no solo su implementación mediante textos legales o de política, sino también por medio de prácticas sociales. Esto requiere analizar el contexto social más amplio en el que el derecho opera, es decir, el "derecho en la práctica". El propósito final de este artículo es invitar a la acción colaborativa entre investigadores de las áreas jurídicas y sociales. Dicha acción implica para los juristas investigadores, el reto de incorporar teorías novedosas como el NRJ en sus estudios, a fin de adelantar un análisis normativo que tome en cuenta perspectivas más amplias y holísticas sobre el derecho. Finalmente, y dado el actual campo de investigación de la autora, se incluye una breve reflexión sobre la utilidad de adoptar el NRJ en los estudios sobre la implementación de la Convención sobre los Derechos de las Personas con Discapacidad (CDPD). Esta es un área de investigación por explorar.

Resumo O novo realismo jurídico (NRJ) é uma perspectiva teórica que promove uma relação colaborativa entre o direito e as ciências sociais. Essa teoria amplia o horizonte dos estudos legais ao situar as problemáticas jurídicas em seus contextos sociais mais amplos e garante um estudo científico do direito. Neste artigo, reflete-se sobre a utilidade de adotar o NRJ nos estudos legais sobre a imple mentação do direito e, em especial, do direito internacional. A partir de uma revisão da literatura, são discutidas quatro características do NRJ: caráter centralizado nas normas jurídicas, promoção da pesquisa interdisciplinar, promoção da pesquisa empírica e promoção da pesquisa ativa e crítica no direito. Conclui-se que adotar a perspectiva do NRJ nos estudos sobre a implementação do direito internacional é importante para analisar não somente sua implementação por meio de textos legais ou de política, mas também, mediante práticas sociais. Isso requer analisar o contexto social mais amplo no que o direito opera, isto é, o "direito na prática". O objetivo deste artigo é fazer um chamamento à ação colaborativa entre pesquisadores das áreas jurídicas e sociais. Essa ação implica para os juristas pesquisadores o desafio de incorporar teorias novas como o NRJ em seus estudos a fim de realizarem uma análise normativa que considere perspectivas mais amplas e holísticas sobre o direito. Finalmente, tendo em vista o atual campo de pesquisa da autora, é apresentada uma breve reflexão sobre a utilidade de adotar o NRJ nos estudos sobre a implementação da Convenção sobre os Direitos das Pessoas com Deficiência. Esta é uma área de pesquisa a ser explorada.

Abstract New Legal Realism (NLR) is a relevant theoretical strand advancing a constructive relationship between law and the social sciences. NLR broadens the 'scene' in legal studies by placing legal issues in their broader social contexts and follows the aspiration of the scientific study of law. Based on the literature review, this article presents a brief discussion on NLR. It argues that an NLR approach might be useful for carrying out research on compliance with (international) law in practice, i.e., the 'law-in-action'. This article finds that four main characteristics of NLR, mainly its law-centred, interdisciplinary, empirical, and constructive legal action character yields useful results to analyse States' compliance with the law. It concludes that an NLR approach contributes to moving from exploring law in books to investigate 'law-in-action'. This involves analysing compliance with the (international) law through domestic law and policy instruments, as well as compliance through social practices. This means to explore the social context within which the law operates. In other words, to investigate the impact of the law at the point of delivery (or the 'law-in-action'). The underlying purpose of this article is thus to call for collaborative action among legal and social scientific researchers by considering to adopt novel theories, such as NLR, to mix normative legal analysis with consideration of broader and holistic perspectives on the law. Lastly, due to the current research interests of the author, this article includes a brief reflection on adopting an NLR approach to analyse State Parties' compliance with the UN Convention on the Rights of Persons with Disabilities (UN CRPD). Notably, in the available literature, this is an underexplored issue.

Resumo Este artigo propõe uma sinergia metodológica entre os estudos linguísticos com base em grandes corpora e os estudos do discurso, trazendo como contribuição as possibilidades de trabalho com anotação linguística. A análise tem o elemento gênero como operador analítico, selecionando uma de suas dimensões: caracterizações atribuídas a personagens femininas e masculinas. A pesquisa tomou por base um grande acervo composto por mais de 200 obras da literatura brasileira em domínio público (cerca de 5 milhões de palavras). A partir da busca por estruturas linguísticas indicativas de predicação, distinguimos quatro eixos de análise, ampliando um tipo de trabalho que normalmente se restringe aos estudos de caso. Ao longo do artigo, e graças às ferramentas computacionais, alternamos entre lentes que nos afastam e nos aproximam do texto, tentando tirar o melhor proveito de cada uma delas. Por fim, argumentamos que é possível e desejável superar as dicotomias quantitativo x qualitativo e conteúdo x discurso.

Abstract This paper proposes a methodological synergy between corpus linguistics and discourse studies. We use a literary corpus composed of more than 200 books of Brazilian literature (about 5 million words) and present a quantitative and qualitative analysis that takes the gender element as an analytical operator, selecting one of its dimensions: characterizations attributed to female and male characters. Searching for linguistic structures indicative of predication, we distinguished four axes of analysis (appearance, emotion, character e social role), expanding a type of research that is normally restricted to case studies. Using computational tools, we switch the glasses that bring the text to a close or a distant reading, making the best of each of these perspectives. The results reinforce the idea of female characterization centered on appearance (specifically on beauty), but also signal the importance of taking into account not only the high frequency elements of the corpus.

Polygamy, which was practiced without limitations in the past, had been restricted to four wives after the arrival of Islam in the Arabian Peninsula. However, some scholars have different views on this issue, supposedly influenced by the literal and cultural background of patriarchal tradition on treating women as the object of polygamy. This article attempts to examine the construction of patriarchal interpretation in a gender-biased interpretation, its factors and its implications. This study adopts a qualitative approach and employs a content analysis approach. Interviews with relevant scholars are also used to explore in-depth information regarding this subject. The object of research is based on a full set (30 juz/chapters) of 11 books of tafsir written in Indonesia. These books are Tafsir Al-Furqan, Tafsir Quran, Adz-Dzikra: Terjemah dan Tafsir al-Quran, Al-Quran dan Terjemahnya, Tafsir Quran Karim, Tafsir al-Azhar, Tafsir Rahmat, Tafsir al-Quran al-Majid an-Nur, Tafsir al-Mishbah, Al-Quran and its Exegesis of the Department of Religion, and Tafsir al-Hijri. This study found that women have been exploited through polygamy practices. Our findings show that biased gender interpretation, especially because of the patriarchal mindset, brought a greater impact on the Quranic interpretation. This study suggested that reinterpretation towards Quranic verses particularly dealing with gender issues needs to be strengthened in accordance with justice and humanistic values. CONTRIBUTION: This article offered two approaches for the study of the Quran in order to establish gender equality and justice in marriage practice. Firstly, the adaptive and humanistic interpretations of the Quran need to be strengthened and should raise common consciousness in Muslim society. Secondly, there is a need to study the Quran in an integrative, holistic and hermeneutical understanding of the Quranic text. This method can explore the deepest meaning of the Quran so it can rise gender-sensitive, humanist and moderate interpretations

Resumen Introducción: CRISPR-Cas9 es actualmente la herramienta más versátil en la ingeniería genética y, por su bajo costo y habilidad para editar genomas fácilmente, la usa toda la comunidad científica. Ofrece promesas considerables en todo campo biológico, especialmente en la comunidad biomédica para curar enfermedades. Sin embargo, a pesar del apoyo general para su utilización clínica, existen preocupaciones éticas y, sobre todo, respecto a su eficacia y seguridad en el contexto de su uso para editar el genoma humano. Objetivo: Revisar la literatura académica y popular sobre los problemas y las implicaciones sobre el uso de CRISPR-Cas9 en la línea germinal humana. Métodos: Búsqueda en las bases de datos PubMed y Embase con términos indexados y libres, periódicos y libros de alta circulación. Resultados: Se seleccionaron 59 documentos según los criterios de inclusión y, a partir de ellos, se crearon cuatro capítulos que revisan las limitaciones técnicas, las implicaciones éticas, la actividad regulatoria e implicaciones políticas y jurídicas respecto del uso de CRISPR-Cas9 en la línea germinal humana, así como las implicaciones para Colombia. Conclusiones: Aunque las limitaciones técnicas se superarán con avances tecnológicos, las preocupaciones éticas son permanentes y han llevado a declaraciones que van desde la prohibición o la moratoria hasta su uso bajo condiciones estrictas. Colombia debe abordar los retos éticos y regulatorios intentando fortalecer sus capacidades institucionales y el debate público.

Abstract Introduction: Currently, CRISPR-Cas9 is the most versatile tool in genetic engineering and, because of its low cost and ability to easily edit genomes is used by the scientific community. It offers considerable promises in every biological field, and in the biomedical community especially to cure diseases. However, despite the general support for its clinical use, there are ethical concerns, and efficacy and safety issues in the context of its use to edit the human genome. Objective: To review academic and lay literature about the concerns and implications to consider about the use of CRISPR-Cas9 in the human germline. Methods: The PubMed and Embase databases were searched using MeSH terms and free terms, as well as newspapers and books of high circulation. Results: 59 documents were selected according to the inclusion criteria and from them were created four chapters that review the technical limitations, the ethical concerns, the regulatory activity and political and judicial implications of using CRISPR-Cas9 in the human germline and the implications for Colombia. Conclusions: Atthough the technical limitations will be overcome by technological advances, the ethical concerns are permanent and have brought statements that go from ban or moratorium, to its use under strict conditions. Colombia should take seriously the ethical and regulatory challenges trying to strengthening the institutional capacities and the public debate.