This paper presents the stages of an acceleration program focused on chemical technologies. We demonstrate how this initiative contributes to the creation of new businesses, startups, and technology licensing from research developed at Brazilian universities. The case of the program Escale-se is discussed. There were 66 technologies submitted, and 14 were selected for the pre-acceleration phase. In this phase, various contents were worked on, such as creating a business model and aspects of scaling hard-science technologies. Teams were evaluated by panels with market specialists, and 6 were selected for the second phase: pre-scaling/proof of concept. Here, proponents were encouraged to validate the business model by connecting with potential clients and partners, as well as planning the development and testing of the product in a relevant environment. Finally, one team was classified for the last stage: scaling/go-to-market - where they received R$ 100,000.00 to scale up their technology and create strategies for raising investments. Four of the fourteen technologies selected for the program opened National Register of Legal Entities (CNPJ) and raised approximately R$ 4.5 M in investments from different sources. These results demonstrate that the methodology contributed to the entrepreneurial development of participating researchers and the raising of funds for the businesses created. startups universities Escalese Escale se discussed submitted 1 preacceleration pre phase hardscience hard science specialists prescaling/proof prescalingproof scaling/proof proof concept Here partners environment Finally stage scaling/gotomarket scalinggotomarket scaling/go go R 10000000 100 000 00 100,000.0 CNPJ (CNPJ 45 4 5 4. sources created prescaling scalingproof gotomarket scalinggo 1000000 10 0 100,000. 100000 100,000 10000 100,00 1000 100,0 100,

Abstract Over the last few years, a context of poverty and uncertainty has been looming over the future of Brazil, bringing an increase in cost of living and unemployment along with it. In the face of this scenario, it is necessary to look for other opportunities for work and remuneration. As such, entrepreneurship appears as a possibility to generate an income source. Entrepreneurs do not always start businesses following conventional management theories, as they are subjects just looking for an opportunity to help them survive. This study looks for a possible characterization of the social innovator in a crossroads through the theories of three authors: Souza Neto, Sarasvathy and Carrieri, who focus on the entrepreneur performing social innovation, generating income for themselves and, most times, solving issues that have not been yet solved by the State in their territory. This study compares the aforementioned theories through an integrational literature review performed in 2022, with field observations of the researchers with entrepreneurs in peripheral areas as of 15 years ago. The objective is to characterize the social innovator in a crossroads in an attempt to extend the field of view to the small entrepreneur using gaps in the system, without systematic knowledge of management to perform their entrepreneurial activities.

Resumen Un contexto de pobreza e incertidumbre sobre el futuro azota a la población brasileña en los últimos años, trayendo consigo aumento del costo de vida y desempleo. En este escenario, es necesario buscar otras oportunidades de trabajo y remuneración. El emprendimiento por necesidad surge entonces como una opción posible para generar ingresos. Y estos emprendedores no siempre inician sus negocios de acuerdo con las teorías administrativas convencionales, ya que son individuos que buscan oportunidades de supervivencia. Este trabajo busca una posible caracterización del innovador social encrucijada, a través de la teoría de tres autores: Souza Neto, Sarasvathy y Carrieri, quien es el emprendedor que innova socialmente generando ingresos para sí mismo y la mayor parte del tiempo resolviendo problemas que aún no han sido resueltos por el Estado en sus territorios. Buscamos caracterizar al innovador social en la encrucijada en un intento de ampliar la mirada de este pequeño empresario que aprovecha los vacíos del sistema sin un conocimiento sistemático de la administración para llevar a cabo su forma de emprender.

Resumo Há um contexto de pobreza e incerteza perante o futuro no Brasil dos últimos anos, trazendo consigo o aumento do custo de vida e o desemprego. Nesse cenário faz-se necessária a busca por outras oportunidades de trabalho e remuneração. O empreendedorismo por necessidade surge, então, como uma opção possível para gerar renda. Estes empreendedores nem sempre começam os seus negócios de acordo com as teorias administrativas convencionais, pois são sujeitos que buscam oportunidades de sobrevivência. Este trabalho busca uma possível caracterização do inovador social de encruzilhada, através da teoria de três autores: Souza Neto, Sa-rasvathy e Carrieri, que focam no empreendedor que inova socialmente gerando renda para si e, na maior parte das vezes, resolvendo questões que ainda não foram resolvidas pelo Estado em seus territórios. Este trabalho compara estas teorias por meio de uma revisão integrativa de literatura realizada em 2022, com as observações de campo das pesquisadoras com empreendedores periféricos, há 15 anos. Buscamos caracterizar o inovador social de encruzilhada na tentativa de ampliar o olhar para esse pequeno empreendedor que utiliza as brechas do sistema sem um conhecimento sistemático de administração para realizar a sua forma de empreender.

SUMMARY: In current study, we used Nissl staining to examine the histological structure of the juvenile Chinese alligator brain, and immunohistochemistry (IHC) staining to detail the serotonin (5-hydroxytryptamine, 5-HT) localization and morphology of neurons belonging to the serotonergic system. Nissl staining revealed that the Chinese alligator brain was divided into four regions (telencephalon, diencephalon, brainstem, and cerebellum) and a connected ventricular system (containing the pair of lateral ventricles, third ventricle, fourth ventricle and the aqueduct). According to the IHC results, 5-HT immunoreactive (5-HT-IR) neurons were primarily observed in the cerebral cortex, the hypothalamic paraventricular nucleus (PH), tectum and tegmentum of the optic lobes, the medial longitudinal fasciculus (Flm) of medulla oblongata and the cerebellar cortex. 5-HT-IR fibers were mostly located lateral to the hypothalamic paraventricular nucleus (PH), in the medial vestibular nucleus (MVe) of the medulla oblongata, and in the choroid plexus (CP) of the lateral ventricles. Additionally, our findings paralleled those results of other reptiles; nevertheless, some distinctions in terms of both histological architecture and function were identified. The layering of the cerebral cortex and tectum, as well as the arrangement of Purkinje cells, differed between reptile brains. The distribution of 5-HT-IR neurons varied in the layer of cerebral and cerebellar cortex when compared to other reptiles. Within the diencephalon, 5-HT-IR neurons formed distinct nuclei in the hypothalamic paraventricular nucleus (PH), but few in the infundibular recess.

RESUMEN: Utilizamos la tinción de Nissl para examinar la estructura histológica del cerebro juvenil del caimán chino y la tinción inmunohistoquímica (IHC) para detallar la localización y morfología de la serotonina (5-hidroxitriptamina, 5-HT) de las neuronas que pertenecen al sistema serotoninérgico. La tinción de Nissl reveló que el cerebro del caimán chino estaba dividido en cuatro regiones (telencéfalo, diencéfalo, tronco encefálico y cerebelo) y un sistema ventricular conectado (que contiene el par de ventrículos laterales, el tercer ventrículo, el cuarto ventrículo y el acueducto). Según los resultados de IHC, las neuronas inmunorreactivas 5-HT (5-HT-IR) se observaron principalmente en la corteza cerebral, el núcleo paraventricular (PH) hipotalámico, el tectum y tegmento de los lóbulos ópticos, el fascículo longitudinal medial (Flm) de médula oblonga y la corteza cerebelosa. Las fibras 5-HT-IR se ubicaron principalmente lateral al núcleo paraventricular (PH) hipotalámico, en el núcleo vestibular medial (MVe) de la médula oblonga y en el plexo coroideo (CP) de los ventrículos laterales. Además, nuestros hallazgos fueron semejantes a los resultados obtenidos de otros reptiles; sin embargo, se identificaron algunas distinciones en términos tanto de arquitectura histológica como de función. Las capas de la corteza cerebral y el tectum, así como la disposición de las neuronas purkinjenses, diferían entre los cerebros de los reptiles. La distribución de las neuronas 5-HT-IR varió en la capa de la corteza cerebral y cerebelosa en comparación con otros reptiles. Dentro del diencéfalo, las neuronas 5-HT-IR formaron núcleos distintos en el núcleo paraventricular (PH) hipotalámico, pero pocos en el receso infundibular.

Resumen: Este artículo proporciona un análisis exhaustivo de los factores que impactan las intenciones, los comportamientos, las innovaciones y el sentido de autoeficacia empresarial en el ecosistema empresarial digital en el Reino de Arabia Saudita. Al ilustrar los roles del ecosistema, la intención empresarial, la innovación y la educación, el estudio aspira proporcionar información sobre las dinámicas distintivas del emprendimiento digital en este entorno geográfico. El estudio utiliza tanto entrevistas cualitativas con expertos en la materia como análisis estadístico cuantitativo de las respuestas de la encuesta. El ecosistema empresarial digital saudita se explora cualitativamente a través de 15 entrevistas con expertos de la industria y cuantitativamente con 248 respuestas a encuestas que permiten probar hipótesis utilizando modelos de ecuaciones estructurales. Los datos cuantitativos de este estudio se analizaron mediante PLS-SEM. Los resultados enfatizan los roles mediadores de la ambición empresarial y la innovación, destacando la importancia clave del ecosistema empresarial digital para impulsar el comportamiento empresarial. La educación empresarial surge como un elemento poderoso que actúa como moderador en la configuración del éxito empresarial. La investigación proporciona información útil sobre las características únicas del emprendimiento digital en Arabia Saudita.

Abstract: This paper provides a comprehensive analysis of the factors impacting entrepreneurial intentions, behaviors, innovations, and the sense of self-efficacy in the digital entrepreneurial ecosystem in the Kingdom of Saudi Arabia. By illuminating the roles of the ecosystem, entrepreneurial intention, innovation, and education, the study aspires to provide insights into distinctive dynamics of digital entrepreneurship in this geographical setting. The study employs both qualitative in-depth interviews with subject matter experts and quantitative statistical analysis of survey responses. The Saudi digital entrepreneurial ecosystem is explored qualitatively through 15 in-depth interviews with industry experts and quantitatively with 248 survey responses that allow for hypothesis testing using structural equation modeling. The quantitative data in this study were analyzed using PLS-SEM. The results emphasize the mediating roles of entrepreneurial ambition and innovation, highlighting the key significance of the digital entrepreneurial ecosystem in driving entrepreneurial behavior. Entrepreneurial education is emerging as a powerful element, acting as a moderator in shaping entrepreneurial success. The research provides useful information about the unique characteristics of digital entrepreneurship in Saudi Arabia.

Abstract The concept of Good Living plays a crucial role in relation to the community and becomes an opportunity to improve the quality of life. This article systematizes the entrepreneurship experience with peasant women from the rural area of Villamaría, Caldas, Colombia, as a contribution to human flourishing. This research followed the guidelines of the Alforja Network, which proposes a systematization framed within dialectical, systemic, and holistic approaches to popular education. The results are presented in three phases: characterization of the families, the environment, and the entrepreneurship production; interdisciplinary accompaniment and sustainability through the structuring of networks and alliances. The experience reflects the ability of women for the Good Living of themselves and their families, collective organization, and innovation. Additionally, it highlights the importance of the role of the State in strengthening local development through the production chain, preserving its rural identity in the context of equitable processes.

Resumen El concepto del Buen Vivir desempeña un papel crucial en la relación con la comunidad y se convierte en una oportunidad para mejorar la calidad de vida. Este artículo sistematiza la experiencia de emprendimiento con mujeres campesinas del área rural de Villamaría, Caldas, Colombia, como una contribución al florecimiento humano. Esta investigación siguió los lineamientos de la Red Alforja, la cual propone una sistematización enmarcada en enfoques dialécticos, sistémicos y holísticos de la educación popular. Los resultados son presentados en tres fases: caracterización de las familias, el entorno y la producción del emprendimiento; acompañamiento interdisciplinario y sustentabilidad a través de la estructuración de redes y alianzas. La experiencia refleja la capacidad de las mujeres para el Buen Vivir de ellas y sus familias, la organización colectiva y la innovación. Además, resalta la importancia del rol del Estado en el fortalecimiento del desarrollo local mediante la cadena de producción, preservando su identidad rural en el contexto de procesos equitativos.

Resumen O conceito do Bom Viver desempenha um papel crucial na relação com a comunidade e converte-se em uma oportunidade para melhorar a qualidade de vida. Este artigo sistematiza a experiência de emprendimento com mulheres campesinas da área rural de Villamaría, Caldas, Colômbia, como uma contribuindo ao florecimento humano. Esta investigação continuou os linhamentos da Red Alforja, a qual propõe uma sistematização enmarcada em enfoques dialéticos, sistêmicos e holísticos da educação popular. Os resultados são apresentados em três fases: caracterização das famílias, o entorno e a produção do emprendimento; acompanhamento interdisciplinário e sustentabilidade através da estructuração de redes e alianças. A experiência reflete a capacidade das mulheres para o Bom Viver delas e suas famílias, a organização coletiva e a inovação. Além disso, ressalta a importância do role do Estado no fortalecimento do desenvolvimento local mediante a cadeia de produção, preservando sua identidade rural no contexto de processos equitativos.

Resumen Representa una necesidad actual comprender y analizar el emprendimiento, como medio para identificar tendencias y guiar futuras investigaciones. El objetivo del presente estudio fue analizar la producción científica acerca del emprendimiento en la base de datos Scopus durante el periodo 2011-2021. Se recolectaron 4,245 artículos de la base de datos Scopus a través de una búsqueda sistemática de palabras claves y filtros con el método prisma. El análisis bibliométrico se realizó empleando los softwares de acceso libre VosViewer y Bibliometrix R. Como resultado se caracterizaron tendencias, se identificaron autores predominantes, países con implicancia en el desarrollo del emprendimiento, así como la evidencia del cumplimiento de la ley de Lotka en la producción científica. El análisis evidenció una tendencia hacia los ecosistemas empresariales; además se halló que el emprendimiento se encuentra vinculado a la innovación y los países que destacan a nivel global son Estados Unidos y China; mientras que en el mundo hispano fueron España y México. Finalmente se encontró evidencia que el emprendimiento promueve el desarrollo económico de las sociedades, particularmente de aquellas que requieren un impulso económico sostenido.

Abstract There is a current need to understand entrepreneurship as a means of identifying trends and guiding future research. The objective of this study was to analyze the scientific production on entrepreneurship in the Scopus database during the period 2011-2021. A total of 4,245 articles were collected from the Scopus database through a systematic keyword search and filters using the prism method. The bibliometric analysis was carried out using the open access software VosViewer and Bibliometrix R. As a result, trends were characterized, predominant authors were identified, countries with implications for the development of entrepreneurship, as well as evidence of compliance with Lotka's law in scientific production. The analysis showed a trend towards entrepreneurial ecosystems; It was also found that entrepreneurship is linked to innovation and the countries that stand out globally are the United States and China; while in the Hispanic world it was Spain and Mexico. Finally, evidence was found that entrepreneurship promotes the economic development of societies, particularly those that require a sustained economic boost.

RESUMEN: La mareína es un compuesto flavonoide que reduce la glucosa y los lípidos en sangre y tiene un efecto protector en la diabetes. Sin embargo, no se han dilucidado el efecto y los mecanismos de la mareína sobre la transición endotelial- mesenquimatosa renal en la enfermedad renal diabética (ERD). En este estudio, los datos de secuenciación unicelular sobre DKD se analizaron utilizando un método de bioinformación y los datos se sometieron a una agrupación de dimensiones reducidas. Se descubrió que las células endoteliales podían dividirse en cinco subgrupos. La secuencia de desarrollo de los subgrupos fue 0, 1, 4, 2 y 3, de los cuales el subgrupo 3 tenía el fenotipo más intersticial. La expresión de la proteína marcadora mesenquimatosa: vimentina (VIM), fibronectina (FN1) y receptor del factor de crecimiento de fibroblastos. 1 (FGFR1) aumentó con la conversión de subgrupos. En ratones db/db de 13 a 14 semanas de edad, que desarrollan complicaciones de DKD después de las 8 a 12 semanas de edad, la mareína redujo los niveles sanguíneos de glucosa, creatinina y nitrógeno ureico, mejoró el daño estructural en el tejido renal y redujo la deposición y expresión de colágeno de FN1 y VIM. Marein también aumentó el marcador de autofagia: Cadena ligera 3II/I (LC3II/I) y disminuyó la expresión de FGFR1 en el tejido renal. En un modelo de transición endotelial-mesenquimal, un nivel alto de glucosa indujo un cambio fenotípico en las células endoteliales de la vena umbilical humana. Marein disminuyó la migración de células endoteliales, mejoró la morfología de las células endoteliales y disminuyó la expresión de VIM y FN1. El uso del inhibidor de FGFR1, AZD4547, y del inhibidor de la autofagia, 3-metiladenina (3-MA), demostró aún más el efecto inhibidor de la mareína en la transición endotelial-mesenquimal inducida por niveles altos de glucosa al reducir la expresión de FGFR1 y regular positivamente la proteína marcadora de autofagia. , LC3II/I. En conclusión, este estudio sugiere que la mareína tiene un efecto protector sobre la transición endotelial-mesenquimatosa renal en la ERC, que puede estar mediada por la inducción de autofagia y la regulación negativa de la expresión de FGFR1.

SUMMARY: Marein is a flavonoid compound that reduces blood glucose and lipids and has a protective effect in diabetes. However, the effect and mechanism(s) of marein on renal endothelial-mesenchymal transition in diabetic kidney disease (DKD) have not been elucidated. In this study, single-cell sequencing data on DKD were analyzed using a bioinformation method, and the data underwent reduced dimension clustering. It was found that endothelial cells could be divided into five subclusters. The developmental sequence of the subclusters was 0, 1, 4, 2, and 3, of which subcluster 3 had the most interstitial phenotype.The expression of mesenchymal marker protein:Vimentin(VIM), Fibronectin(FN1), and fibroblast growth factor receptor 1 (FGFR1) increased with the conversion of subclusters. In db/db mice aged 13-14 weeks, which develop DKD complications after 8-12 weeks of age, marein reduced blood levels of glucose, creatinine, and urea nitrogen, improved structural damage in kidney tissue, and reduced collagen deposition and the expression of FN1 and VIM. Marein also up-regulated autophagy marker:Light chain 3II/I(LC3II/I) and decreased FGFR1 expression in renal tissue. In an endothelial-mesenchymal transition model, a high glucose level induced a phenotypic change in human umbilical vein endothelial cells. Marein decreased endothelial cell migration, improved endothelial cell morphology, and decreased the expression of VIM and FN1. The use of the FGFR1 inhibitor, AZD4547, and autophagy inhibitor, 3-Methyladenine(3-MA), further demonstrated the inhibitory effect of marein on high glucose-induced endothelial-mesenchymal transition by reducing FGFR1 expression and up-regulating the autophagy marker protein, LC3II/I. In conclusion, this study suggests that marein has a protective effect on renal endothelial- mesenchymal transition in DKD, which may be mediated by inducing autophagy and down-regulating FGFR1 expression.

Abstract Objective: This article presents theoretical findings from the research project “Experience, Ethics, and Subject in Foucaults Later Work,” which conceptualizes the theoretical-methodological categories of the philosophers last period of work. The text examines the educational dimension of contemporary neoliberalism, located in human capital as a discourse and practice that generates scenarios of formation and the constitution of subjectivities guided by international policies and practices in secondary and higher education institutions. Originality/support: It contributes to recent consolidated studies as a philosophy of education, employing concepts and categories from philosophy to problematize and study with effects of policies and types of economy in the field of educational sciences and pedagogy. Method: The methodology is closely aligned with Michel Foucaults archaeological-genealogical-ethical approach, manifested through various instruments such as thematic and analytical cards that allow for the recognition of statements and conceptual series that reorganize the ways in which the educational forms of neoliberalism have been constituted and their effects on contemporary subjects and institutions. In addition to this procedure, the essay-problematization is employed, not merely as a description of the constructed situation, but with the intention and conviction of transforming the researcher. That is, beyond seeking the documentation of the social practices produced in the discourses, it focuses on how the subject gets concerned and generates different possibilities of action. Strategies/Data collection: The article draws on theoretical and documentary sources from philosophy and economics, with a focus on Foucaults courses at the Collège de France during the years 1977-1979. It also delves into the analyses of American neoliberals (Schultz, Becker), theorists of human capital, who postulate the economic value of education. Conclusions: Contemporary education in Colombia and Latin America is co-opted by neoliberalism as a worldview. This is evidenced by the prominence of human capital as a formative scene that directs students and teachers towards the competency model, materialized in curriculum plans and institutional ventures such as innovation, entrepreneurship, and the management of individuals as architects of their own destiny becoming entrepreneurs to offer their skills in various labor markets.

Resumo Objetivo: Este artigo descreve um workshop interativo baseado numa aplicação da análise crítica do discurso, enquadrada a partir de uma posição enunciativo-pragmática que considera as condições de produção, circulação e receção do discurso, para mostrar a utilidade da sociopragmática nesta área. Originalidade/suporte: A sociopragmática como ferramenta epistemológica para a análise crítica do discurso. Método e estratégias/coleta de datos: A primeira fase contém um esboço do campo concetual das áreas disciplinares envolvidas. As categorias cognitivas remetem para o conceito de acções de linguagem, ideologia de género e ideologia na linguagem que serão úteis para sustentar as posições e preconceitos encontrados; são considerados os quadros sociais de referência que geram a estigmatização 182 resultante. Utiliza-se o conceito de imagem social e outros contributos que o complementam, como o imaginário sócio-discursivo, a direccionalidade e o efeito das actividades de imagem, elementos que, numa amálgama ideológica, colaboram na interpretação das actividades de imagem e na imagem socialmente projectada. Na segunda fase, realiza-se um trabalho de grupo para examinar, registar e documentar as marcas indiciais, as acções, os recursos e outros elementos discursivos que facilitam a construção de uma abordagem. Estou empenhado na utilidade heurística de articular uma abordagem interdisciplinar a uma amostra de discurso popular. A experiência pode ser extrapolada para outros objectos de estudo dos participantes na oficina. Conclusões: Este trabalho cumpriu o objetivo pretendido, que era ilustrar como uma análise crítica do discurso - que faz uso de algumas ferramentas relacionadas com diferentes disciplinas, incluindo a sociopragmática - permite o acesso didático a vários níveis de análise que facilitam a interpretação do significado discursivo.

Resumen Objetivo: El artículo presenta resultados teóricos del proyecto de investigación “Experiencia, ética y sujeto en el último Foucault”, que conceptualizó las categorías teórico-metodológicas del último periodo de trabajo del filósofo; en el texto se plantea la dimensión educativa del neoliberalismo contemporáneo ubicada en el capital humano como discurso y práctica que produce escenarios de formación y constitución de subjetividades orientados por las políticas de orden internacional y las prácticas en las instituciones educativas de básica media y superior. Originalidad/aporte: Se circunscribe a los estudios consolidados en el último tiempo como filosofía de la educación, en el sentido de utilizar conceptos y categorías de la filosofía para problematizar y estudiar con efectos producidos por políticas y formas de la economía en el campo de las ciencias de la educación y la pedagogía. Método: La metodología está cercana al enfoque arqueológico-genealógico-ético de Michel Foucault, materializado en diferentes instrumentos como fichas temáticas y analíticas que permiten reconocer los enunciados y las series conceptuales que reorganizan la manera como se han constituido las formas educativas del neoliberalismo y los efectos sobre sujetos e instituciones contemporáneas; aparte del procedimiento, se acude al ensayo-problematización no como una simple descripción de la situación construida, sino con la intención y el convencimiento de la transformación del sujeto investigador; es decir, no registrar las prácticas sociales producidas en los discursos, sino las formas como el sujeto se inquieta y genera diferentes posibilidades de acción. Estrategias/recolección de información: El artículo recurre a fuentes teóricas y documentales de la filosofía y la economía, privilegiando los cursos de Foucault impartidos en el Collège de France durante los años 1977-1979, al tiempo que se detiene en los análisis de los neoliberales norteamericanos (Schultz, Becker), teóricos del capital humano, quienes postulan el valor económico de la educación. Conclusiones: La educación contemporánea en Colombia y América Latina está cooptada por el neoliberalismo como visión de mundo. Esta comprobación se concreta en el capital humano como escena formativa que incluye volcar a estudiantes y profesores sobre el modelo de competencias y su materialización en planes de estudio y aventuras institucionales como la innovación, el emprenderismo y la gestión de los sujetos como forjadores de su propio destino, ser empresarios de sí mismos para ofertarse en los diferentes mercados laborales.

Resumo O talento e as características artísticas destes empreendedores podem criar ecossistemas de inovação cultural, pois existe uma efervescente criatividade que pode e deve ser usada em prol do território. Essa conexão pode mitigar problemas econômicos e sociais, ativando o pertencimento da comunidade e ofertando visibilidade aos fazedores de cultura. O presente estudo visa investigar as contribuições de microempreendimentos do ramo da cultura para o desenvolvimento regional na região metropolitana do Rio de janeiro. Esses empreendimentos corroboram para o equilíbrio econômico e social do território; potencializando recursos culturais existentes, ofertando pertencimento e renda para a comunidade local. Foi realizada a revisão sistemática dividida em duas etapas, primeiro na formação do portfólio bibliográfico e nos resultados extraídos do procedimento; depois, procurou-se analisar a conexão entre desenvolvimento regional com a cultura. Foram utilizadas três bases indexadas, a Web of Science, SciELO e Scopus, com o período de buscas entre 2001 até 2021, que retornou, depois do processo de elegibilidade, 102 artigos. Percebeu-se que a ligação das palavras-chave “empreendedorismo cultural” e “desenvolvimento regional” era pouco discutida em revistas de maior relevância para o debate no mundo; no entanto, existia uma lacuna cientifica importante para o debate acadêmico, como a transversalidade que a cultura é capaz de gerar a partir de seus produtos e serviços. cultural território sociais janeiro existentes local etapas procedimento procurouse procurou se indexadas Science Scopus 200 2021 retornou elegibilidade 10 artigos Percebeuse Percebeu palavraschave palavras chave empreendedorismo mundo entanto acadêmico serviços 20 202 1 2

Abstract The talent and artistic characteristics of these entrepreneurs can create ecosystems of cultural innovation, as there is an effervescent creativity that can and should be used in favor of the territory. This connection can mitigate psychological and social problems, activating community belonging and offering visibility to culture makers. This study aims to investigate the contributions of microenterprises in the field of culture to regional development in the metropolitan region of Rio de Janeiro. These developments contribute to the economic and social balance of the territory; leveraging existing cultural resources, offering belonging and income to the local community. A systematic review was carried out divided into two stages, first in the formation of the bibliographic portfolio and in the results extracted from the procedure, then the connection between regional development and culture was analyzed. Three indexed databases were used, the Web of Science, SciELO and Scopus, with the search period between 2001 and 2021, which underwent 102 articles after the eligibility process. It was noticed that the link between the keywords “cultural entrepreneurship” and “regional development” was little interned in magazines that were more protective of the debate in the world; however, there was an important scientific gap for the academic debate, such as the transversality that culture is capable of generate from your products and services. innovation territory problems makers Janeiro resources stages procedure analyzed Science Scopus 200 2021 10 process entrepreneurship world however services 20 202 1 2

Resumen El talento y las características artísticas de estos emprendedores pueden generar ecosistemas de innovación cultural, ya que existe una creatividad efervescente que puede y debe ser utilizada a favor del territorio. Esta conexión puede mitigar problemas psicológicos y sociales, activando la pertenencia comunitaria y brindando visibilidad a los hacedores de cultura. Este estudio tiene como objetivo investigar las contribuciones de las microempresas en el campo de la cultura para el desarrollo regional en la región metropolitana de Río de Janeiro. Estos desarrollos contribuyen al equilíbrio económico y social del territorio; aprovechando los recursos culturales existentes, ofreciendo pertenencia e ingresos a la comunidad local. Se realizó una revisión sistemática dividida en dos etapas, primera en la conformación del portafolio bibliográfico y en los resultados extraídos del procedimiento, luego se analizó la conexión entre desarrollo regional y cultura. Se utilizaron tres bases de datos indexadas, la Web of Science, SciELO y Scopus, con el período de búsqueda entre 2001 y 2021, lo que resultó en 102 artículos después del proceso de elegibilidad. Se percibió que el vínculo entre las palabras clave “emprendimiento cultural” y “desarrollo regional” fue poco internado en las revistas más protectoras del debate en el mundo; sin embargo, hubo un vacío científico importante para el debate académico, como la transversalidad que la cultura es capaz de generar a partir de sus productos y servicios. cultural territorio sociales Janeiro existentes local etapas procedimiento indexadas Science Scopus 200 2021 10 elegibilidad emprendimiento mundo embargo académico servicios 20 202 1 2

ABSTRACT Professional orientation and entrepreneurship emerge as a necessary relationship in Cuban Higher Education, taking into account the need to stimulate the training of entrepreneurial students with professional life projects that enable their contribution to the municipality as a space for the common good. By virtue of what has been expressed, the article intends to socialize an educational strategy aimed at gradually promoting entrepreneurship, from the professional orientation process. The proposal was structured into three specific strategic actions: redefinition of entrepreneurship as a process and result, training for the pedagogical group and the design of professional orientation workshops "Youth, entrepreneurship and local development." For this, a qualitative methodology was used that considers the interpretation of the results from a dialectical conception, with the use of historical-logical methods, modeling and the help of documentary analysis and the Iadov technique for the evaluation of the proposal. The results reveal the potential of an educational strategy that contains actions and operations that favor the training of entrepreneurial students with professional life projects that stimulate the use of knowledge for prosperous, sustainable, equitable and inclusive municipal development.

RESUMO A orientação profissional e o empreendedorismo surgem como uma relação necessária no Ensino Superior cubano, tendo em conta a necessidade de estimular a formação de estudantes empreendedores com projetos de vida profissional que possibilitem a sua contribuição para o município como espaço de bem comum. Em virtude do exposto, o artigo pretende socializar uma estratégia educativa que visa promover gradativamente o empreendedorismo, a partir do processo de orientação profissional. A proposta foi estruturada em três ações estratégicas específicas: redefinição do empreendedorismo como processo e resultado, formação do grupo pedagógico e concepção de oficinas de orientação profissional "Juventude, empreendedorismo e desenvolvimento local". Para isso, utilizou-se uma metodologia qualitativa que considera a interpretação dos resultados a partir de uma concepção dialética, com utilização de métodos histórico-lógicos, modelagem e auxílio da análise documental e da técnica de Iadov para a avaliação da proposta. Os resultados revelam o potencial de uma estratégia educacional que contenha ações e operações que favoreçam a formação de estudantes empreendedores com projetos de vida profissional que estimulem o uso do conhecimento para o desenvolvimento municipal próspero, sustentável, equitativo e inclusivo.

RESUMEN Orientación profesional y emprendimiento, emergen como una relación necesaria en la Educación Superior cubana, teniendo en cuenta la necesidad de estimular la formación de estudiantes emprendedores con proyectos de vida profesionales que posibiliten su aporte al municipio como espacio de bien común. En virtud de lo expresado, el articulo tiene la intención de socializar una estrategia educativa orientada a potenciar de modo gradual el emprendimiento, desde el proceso de orientación profesional. La propuesta se estructuró en tres acciones estratégicas específicas: resignificación del emprendimiento como proceso y resultado, la capacitación al colectivo pedagógico y el diseño de talleres de orientación profesional "Juventud, emprendimiento y desarrollo local". Para ello, se utilizó una metodología cualitativa que pondera la interpretación de los resultados desde una concepción dialéctica, con el empleo de los métodos histórico-lógico, la modelación y el auxilio del análisis documental y la técnica de Iadov para la evaluación de la propuesta. Los resultados develan, las potencialidades de una estrategia educativa que contiene acciones y operaciones que favorece la formación de estudiantes emprendedores con proyectos de vida profesionales que estimulan el uso del conocimiento en función un desarrollo municipal prospero, sostenible, equitativo e incluyente.

Abstract: This research aims to identify the “entrepreneurial” characteristics of public universities in Mexico that offer educational programs related to business management. To achieve this, the methodology defined by the Organization for Economic Cooperation and Development (OECD) and the European Commission was used, in addition to a Structural Equation Model (SEM). The results allowed the design of a model tailored to local universities and the identification of the main characteristics of public universities regarding their commitment to promoting entrepreneurship. However, the result showed that they lack an incentive mechanism to make this possible, together with a link to the external sector.

Resumen: El objetivo de la presente investigación es identificar cuáles son las características “emprendedoras” que registran las universidades públicas en México que imparten programas educativos relacionados con la gestión de empresas. Para lograrlo se utilizó la metodología definida por la Organización para la Cooperación y el Desarrollo Económicos (OECD) y la Comisión Europea, además de un modelo de ecuaciones estructurales (Structural Equation Models, SEM, por sus siglas en inglés). Los resultados permitieron el diseño de un modelo acorde a las universidades locales y la identificación de las principales características de las universidades públicas respecto a su compromiso con la promoción del emprendimiento; no obstante, el resultado reflejó que adolecen de un mecanismo de incentivos que lo haga posible, así como de una vinculación con el sector externo.

RESUMEN El estudio tiene como objetivo analizar cómo mejorar la eficiencia de la producción industrial en Azerbaiyán a través de un análisis integral de sus regiones. En la investigación se utilizan varios métodos, como el análisis analítico comparativo y un enfoque sistemático, utilizando categorías de desarrollo económico como productividad e innovación. El estudio subraya la importancia de considerar aspectos legales, políticos, económicos, morales y psicológicos para el desarrollo sistemático e integral de la producción industrial. Se enfatiza el papel regulador del Estado, las perspectivas de desarrollo sostenible en el sector no petrolero, el uso del capital humano para fomentar el espíritu empresarial a través de la competencia leal y la asignación estratégica de empresas industriales e inversiones entre regiones. Se hacen recomendaciones con el objetivo de atraer y mejorar las inversiones, resolver los desafíos socioeconómicos en las regiones y crear un mejor marco legal.

ABSTRACT The study aims at analyzing how to enhance industrial production efficiency in Azerbaijan through a comprehensive analysis of its regions. In the research, various methods are used such as comparative analytical analysis and a systematic approach, utilizing economic development categories like productivity and innovation. The study underscores the importance of considering legal, political, economic, moral, and psychological aspects for the systematic and comprehensive development of industrial production. It is emphasized the regulatory role of the state, prospects for sustainable development in the non-oil sector, the use of human capital to foster entrepreneurship through fair competition, and strategic allocation of industrial enterprises and investments across regions. Recommendations are made aiming at attracting and improve the investments, resolving socio-economic challenges in regions, and creating a better legal framework.

ABSTRACT The plastic film materials are a widely used agricultural means of production. Recently, two types of new agricultural film mulches are developed and are used popularly. They are ethylene-vinyl acetate copolymer (EVA) and polyolefin (PO) film mulches. The transmittances of film mulches are related to thermal reservation and plant photosynthesis. We experimentally measure transmittances of several EVA and PO film mulches under different wavelengths. We also find that the transmittances of mulches vary with light intensity change at one wavelength. The variable transmittances for these mulches are also measured in experiments. These data measured can provides help for agricultural production and accurate numerical simulation for the establishment microclimate of plastic greenhouse, even the degradation of plastic films. Recently popularly ethylenevinyl ethylene vinyl (EVA (PO photosynthesis wavelengths wavelength experiments greenhouse films

Abstract Pulmonary mesenchymal stem cells (PMSCs) are considered important in therapeutic and regenerative responses to lung injury. Despite extensive studies on the human, porcine, sheep, mouse and rat, it was found that PMSCs, which can been performed on goose, have not been well explored. Elucidation of cell differentiation, proliferation, which have not yet been well described, may promote the development of injured lung therapy. In our study, we firstly disclosed biological characteristics of spindle-shaped PMSCs from pulmonary tissues of goose embryos. Growth kinetics and counting kit-8 (CCK8) assay were employed for proliferative activity evaluation. When appropriately induced, PMSCs could differentiate into osteoblasts, adipocytes, chondrocytes, type II alveolar epithelial cells (ATII), which demonstrated that PMSCs have cross-embryonic layer differentiation potential. Besides, undifferentiated PMSCs consistently expressed MSCs associated phenotypes, such as CD166, CD90, CD44, CD29, CD71 and CD105, as identified by immunohistochemistry and RT-PCR. Karyotype analysis demonstrated that PMSCs possessed stable diploid karyotype. Collectively, we successfully established applicable methods for isolation, culture, identification and characterization of goose PMSCs which suggested a potential therapeutic use in regenerative therapy. (PMSCs injury human porcine sheep rat explored proliferation described therapy study spindleshaped spindle shaped embryos kit8 kit 8 kit- CCK8 CCK (CCK8 evaluation induced osteoblasts adipocytes chondrocytes ATII, ATII , (ATII) crossembryonic cross embryonic Besides phenotypes CD166 CD CD90 CD44 CD29 CD7 CD105 RTPCR. RTPCR RT PCR. PCR RT-PCR karyotype Collectively isolation culture (CCK (ATII CD16 CD9 CD4 CD2 CD10 CD1

ABSTRACT Entrepreneurship plays a significant role in a country's development, through new ventures and innovation. In recent times, entrepreneurs have incorporated sustainability into their practice to become more competitive and productive. However, during the COVID-19 pandemic, entrepreneurship has faced the challenge of deciding to allocate limited resources to maintain legitimacy. This paper analyzes the relationship between legitimacy and financial sustainability in COVID-19 times among Colombian entrepreneurs, moderated by family and friends' support. Primary data was collected through a survey of 219 Colombian entrepreneurs. The structural equation model technique was used to validate the model. The study findings revealed that legitimacy positively affects financial sustainability and is positively enhanced by the family's support of Colombian entrepreneurs while being negatively moderated by friends' support. countrys country s development innovation productive However COVID19 COVID 19 COVID-1 pandemic friends 21 familys COVID1 1 COVID- 2

RESUMO O empreendedorismo desempenha um papel significativo no desenvolvimento de um país por meio de novos empreendimentos e inovação. Nos últimos tempos, os empresários incorporaram a sustentabilidade em sua prática para se tornarem mais competitivos e produtivos. No entanto, durante a pandemia do COVID-19, o empreendedorismo enfrentou o desafio de decidir alocar recursos limitados para manter a legitimidade. Este artigo analisa a relação entre legitimidade e sustentabilidade financeira em tempos de COVID-19 entre empreendedores colombianos, moderada pelo apoio de familiares e amigos. Os dados primários foram coletados por meio de uma pesquisa com 219 empreendedores colombianos. A técnica do modelo de equação estrutural foi usada para validar o modelo. Os resultados do estudo revelaram que a legitimidade afeta positivamente a sustentabilidade financeira e é positivamente reforçada pelo apoio da família aos empresários colombianos, enquanto negativamente moderada pelo apoio dos amigos. inovação produtivos entanto COVID19, COVID19 COVID 19, 19 COVID-1 colombianos amigos 21 COVID1 1 COVID- 2