To discover new bisamide compounds with insecticidal and fungicidal activities, 19 novel cyproflanilide derivatives containing 1,2,4-oxadiazole group were designed and synthesized according to the principle of biologically active factor splicing. Preliminary biological assay data indicated that the majority of target compounds demonstrated significant insecticidal activity against Lepidopteran pests. Meanwhile, compounds 5p and 5q showed 97.22 and 100% lethality against Tetranychus cinnabarinus at 400 mg L-1, which were better than cyproflanilide (41.11% at 400 mg L-1). In addition, it is exciting that we have achieved our initial goals as some of the target compounds exhibited both insecticidal and fungicidal activities. For instance, compounds 5b and 5c showed 59.26 and 74.07% fungicidal activities against Cucumber downy mildew at 400 mg L-1, as well as 100% insecticidal activity against Plutella xylostella and armyworm at 100 mg L-1. Compound 5h showed 100% insecticidal activity against armyworm at 10 mg L-1, and also displayed 66.67% fungicidal activity against Cucumber downy mildew at 400 mg L-1. The inhibition rate of compounds 5l and 5s against Cucumber downy mildew reached 88.89 and 96.30% at 400 mg L-1. This work showed the effectively fungicidal application of 1,2,4-oxadiazole group in bisamide compounds and provides insights for optimal structural design. 1 1,2,4oxadiazole 124oxadiazole oxadiazole 1,2,4 2 4 splicing pests Meanwhile p q 9722 97 22 97.2 40 L1, L1 L 1, L-1 41.11% 4111 41 11 (41.11 L1. . L-1) addition instance b c 5926 59 26 59.2 7407 74 07 74.07 1. h 6667 66 67 66.67 l s 8889 88 89 88.8 9630 96 30 96.30 design 4oxadiazole 124 1,2, 972 9 97. L- 41.11 411 (41.1 592 5 59. 740 7 0 74.0 666 6 66.6 888 8 88. 963 3 96.3 12 1,2 41.1 (41. 74. 66. 96. 41. (41 (4 (

Resumen Introducción: La administración del calostro a través de su absorción a nivel orofaríngeo estimula el tejido linfoide asociado a mucosas, proporcionando una barrera de protección local e inmunológica. Conocer la asociación de la administración de calostro orofaríngeo con la disminución de los índices inflamatorios. Material y métodos: Observacional, ambispectivo, analítico, recién nacidos < 32 semanas de gestación con riesgo de sepsis, se administró calostro orofaríngeo 0.2 ml cada 4 horas durante 5 días. se analizó índices inflamatorios, evolución clínica. Análisis estadístico: frecuencias, porcentajes, media y DS, coeficiente de contingencia y prueba de Kolmogorov Smirnov para la curva de distribución de los datos numéricos. Resultados: Fueron 50 pacientes, 33 (66%) femenino, 17 (34%) masculino, edad gestacional mediana 30-31 semanas (IC 95%), 19 pacientes cursaron con sepsis encontrando menor índice de positividad en la PCR, mediana de 0.5-0.6 (IC 95%) a los 5 días de administración de calostro vs 0.5-1.1 (IC 95%) como PCR inicial, analizando con Chi cuadrada con valor p = 0.13, mediante coeficiente de contingencia con p = 0.196, traduciendo asociación. Conclusión: La calostroterapia se asoció con menor índice de positividad en la PCR; clínicamente hacia la mejoría, en recién nacidos prematuros con riesgo de sepsis.

Abstract Background: The administration of colostrum through its absorption at the oropharyngeal level stimulates the mucosa-associated lymphoid tissue, providing a local immunological protection barrier. The study aimed to investigate the association of oropharyngeal colostrum administration with the reduction of inflammatory indices. Materials and methods: This was an observational, ambispective, analytical study of newborns < 32 weeks of gestation at risk of sepsis. Oropharyngeal colostrum was administered at 0.2 mL every 4 h for 5 days. Inflammatory indices were analyzed. Statistical analysis included frequencies, percentages, mean and Standard deviation, contingency coefficient, and Kolmogorov–Smirnov test for the distribution curve of the numerical data. Results: There were 50 patients, 33 (66%) female and 17 (34%) male, with a median gestational age of 30-31 weeks (95% confidence interval [CI]). Nineteen patients had sepsis. A lower positivity rate in C-reactive protein was found, with a median of 0.5-0.6 (95% CI) at 5 days of colostrum administration versus 0.5-1.1 (95% CI) as the initial C-reactive protein. Analysis with χ2 yielded a p = 0.13, and the contingency coefficient showed a p = 0.196, indicating an association. Conclusion: Oropharyngeal colostrum administration was associated with a lower C-reactive protein positivity rate and clinical improvement in premature newborns at risk of sepsis.

School readiness assessments in South Africa still predominantly focus on the assessment of cognitive skills. The Emotional Social Screening Tool for School Readiness (E3SR) was developed to bridge the perceived gap in assessing emotional-social skills as a domain of school readiness. An emerging body of research reports exists on the psychometric properties and factor structure of the E3SR. An initial validation study recommended a 6-factor solution instead of the theoretical 9-factor model that was proposed in the development of the E3SR. The E3SR (Revised) was also reduced in length. We report here on a pilot study of which the aim was to establish the reliability and construct validity of the E3SR (Revised). A cross-sectional survey design was used to gather data from 9 pre-schools in Cape Town, South Africa. Pre-school teachers (n = 24) constituted the respondent group who completed the E3SR (Revised) screening questionnaires on Grade R learners (n = 394). Analysis was conducted on 321 completed screening questionnaires. With the data analysis we aimed to: a) summarise sample characteristics of teachers and children; b) establish reliability estimates; and c) establish construct validity and confirming the factor structure. Ethics clearance was given by the Humanities and Social Science Research Ethics Committee (HSSREC) of the University of the Western Cape. The study adhered to stipulated ethics requirements. Data failed to show multivariate normality; however, this violation of normality was expected and was theoretically supported. The sample size (n = 321) was sufficient for factor analysis of a 36-item scale. All subscales showed excellent reliability: Cronbach's alphas ranged between .939 and .971. CFA results demonstrated a good model fit. The E3SR (Revised) was found to be reliable and valid for use. The use of a rigorous methodological process including the decision-making matrix represent good research practice that can be used in instrument development across cultures.

BACKGROUND: Predicting severe Crohn's disease (SCD) can assist in planning risk reduction therapy for SCD, thereby improving disease outcomes OBJECTIVE: To determine the prevalence and predictors of SCD in a sample of South African (SA) patients METHODS: This was a retrospective chart review of patients with Crohn's disease (CD) attending the gastroenterology unit at a tertiary hospital in Durban, SA. Demographic and clinical variables at diagnosis of CD were collected and analysed for statistical associations with SCD (defined as the presence of >1 of the following over the course of CD: complex perianal disease, colonic resection, >2 small-bowel resections, a single small-bowel resection >50cm, or construction of a definitive stoma). The prognostic utility of statistically significant variables was investigated by establishing their sensitivity, specificity and predictive values for SCD RESULTS: The study sample consisted of 93 patients. The rate of SCD was 64.5%, with 63.3% of patients developing SCD within 1 year of CD diagnosis. Ileocolonic location (p=0.046) and penetrating disease at initial diagnosis of CD (p=0.021) were statistically associated with SCD. The sensitivity, specificity, positive predictive value and negative predictive value of ileocolonic location for SCD were 72.7%, 47.4%, 66.7% and 54.6%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value of penetrating disease for SCD were 85.7%, 41.7%, 30.0% and 91.0%, respectively CONCLUSION: Most patients with CD developed SCD within 1 year of their CD diagnosis. CD with a penetrating phenotype at diagnosis is a good predictor for the development of SCD and should be further investigate

Abstract Pastures that include annual and perennial grasses can play a strategic role in increasing the sustainability of temperate livestock systems. However, the impacts of the competition between annual and perennial genetically improved forage species on pastures has scarcely been studied. We evaluated the early dynamics of tillering, carbon partitioning and both intra- and interspecific competition in – or between – an annual (Bromus willdenowii; prairie grass; Bw) and a perennial (Dactylis glomerata; orchard grass; Dg) C3 grass species. We sowed 24 0.18 m2 microplots in May 2008. Each microplot constituted an experimental unit and contained five sowing lines spaced 0.175 m apart. On three of the lines, we sowed different combinations of the mentioned grasses, while on the two lines between them, we sowed red clover (Trifolium pratense). We randomly applied a factorial array of eight treatments—2 species (Dg vs. Bw) × 2 types of competition (intra vs. interspecific) × 2 levels of winter nitrogen fertilization (0 vs. 170 kg of N ha-1)—designed in three complete random blocks. Fertilization did not have any significant effect on any species. The evaluation period lasted 109 days after sowing (das), separated into three phases (0-53 das, 59-90 das and 90-109 das). The variables recorded were aerial biomass (leaves, sheets and senescent material), root biomass and tiller density per species. As expected, annual Bw inhibited the growth of perennial Dg at the latest stage of establishment but surprisingly promoted it at the earliest stage. This work suggested that a low initial density of an annual species should optimize the initial facilitating effect of the annual species on the perennial species with its subsequent inhibitory effect.

Resumen Las gramíneas anuales y perennes pueden desempeñar un papel estratégico en el aumento de la sostenibilidad de los sistemas ganaderos de zonas templadas. Sin embargo, el impacto de la competencia entre especies forrajeras genéticamente mejoradas anuales y perennes en los pastos apenas ha sido estudiado. En este trabajo evaluamos la dinámica temprana del macollaje y la partición de carbono y la competencia intraespecífica e interespecífica en, o entre, una especie de pasto C3 anual (Bromus willdenowii; pasto de la pradera; Bw) y perenne (Dactylis glomerata; pasto de huerto; Dg). Sembramos 24 microparcelas de 0,18 m2 en mayo de 2008. Cada microparcela constituyó una unidad experimental y contenía cinco líneas de siembra espaciadas 0,175 m entre sí. En tres de las líneas sembramos diferentes combinaciones de las gramíneas mencionadas, mientras que en las dos líneas intermedias sembramos trébol rojo (Trifolium pratense). Aplicamos aleatoriamente un conjunto factorial de ocho tratamientos: 2 especies (Dg vs. Bw) × 2 tipos de competencia (intra vs. interespecífica) × 2 niveles de fertilización con nitrógeno invernal (0 vs. 170 kg de N ha-1), diseñado en tres bloques completos al azar. La fertilización no tuvo ningún efecto significativo en ninguna especie. El período de evaluación tuvo una duración de 109 días después de la siembra (dds), separados en tres fases (0-53 dds, 59-90 dds y 90-109 dds). Las variables registradas fueron biomasa aérea (hojas, láminas y material senescente), biomasa de raíces y densidad de macollos por especie. Como se esperaba, Bw inhibió el crecimiento de Dg en la última etapa de establecimiento, pero sorprendentemente lo promovió en la etapa más temprana. Este trabajo sugirió que una baja densidad inicial de una especie anual debería optimizar el efecto facilitador inicial de la especie anual sobre la especie perenne con su posterior efecto inhibidor.

Resumo O linfoma anaplásico de grandes células cutâneo primário (C-ALCL) é um linfoma não-Hodgkin raro com expressão do antígeno CD30 e que não possui manifestações extracutâneas no momento do diagnóstico. O surgimento de pápulas ou nódulos solitários, localizados principalmente no tronco e nas extremidades, são característicos da doença. Neste relato de caso, discorre-se sobre paciente do sexo feminino, 58 anos, com lesão em panturrilha direita de aspecto nodular com crescimento acelerado. Na biópsia, anatomopatológico evidenciou neoplasia maligna de células linfoides/epitelioides. Os aspectos morfológicos, associados ao perfil imunoistoquímico, revelaram desordem linfoproliferativa CD30 positiva em pele, compatível com C-ALCL. Após primeira exérese, surgimento de novas lesões dolorosas em placa de coloração violácea, com realização de nova biópsia. Foi realizada radioterapia durante quatro semanas e as lesões regrediram, porém, recidivaram cerca de um ano após o tratamento. Houve indicação de um novo ciclo de radioterapia para a paciente. A excepcionalidade do C-ALCL justifica o desenvolvimento desse relato de caso, a fim de salientar a importância de se considerar este diagnóstico como uma possibilidade nos linfomas cutâneos de grandes células.

Abstract Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare subtype of non-Hodgkin lymphoma, CD30 positive that does not exhibit extracutaneous manifestations at the time of diagnosis. The emergence of solitary papules or nodules, on the trunk and extremities, characterizes the disease. This case reports a 58-year-old female who presented with a rapidly enlarging nodule on her right calf. The biopsy revealed a malignant neoplasm of large cells. The morphological features, combined with the immunohistochemical profile, revealed a CD30-positive and anaplastic lymphoma kinase-negative lymphoproliferative disorder, consistent with C-ALCL. Shortly after the first excision, new lesions manifested in violaceous papules and nodules, and a new biopsy was performed, confirming the initial diagnosis. The patient underwent radiotherapy for 4 weeks and the lesions regressed but recurred about a year after. The patient is currently under treatment. The main goal is to emphasize the importance of considering this diagnosis as a possibility in large-cell cutaneous lymphomas.

The purpose of this article is to demonstrate how the once-off increase in regional income that will result from investment in roads and the recurring increase in regional income that will stem from the use of economically viable new roads can be estimated. Once-off economic benefits occur because of the multiplier effect triggered by the initial investment expenditure on a road, while recurring economic benefits result from the income accelerator effect that use of the road during its service period will have. To determine the regional income multiplier effect of the investment expenditure on a proposed road during its construction period, it is necessary to estimate (i) the tax amounts included in the investment amount as a ratio of the total project investment amount, (ii) the monetary amount saved by project workers as a ratio of the total project investment amount, and (iii) the expenditure on imported project inputs as a ratio of the total project investment amount. An analysis that incorporates the above-mentioned three fund leakages from the circular flow of regional income will show that the representative income multiplier of South African rural paved road construction projects has a value of 4,58. The gross national income multiplier effect stemming from road construction expenditure can be categorised as follows: In the rating scale above, a gross national income multiplier effect stemming from road construction projects with a value of less than 2,00 is regarded as "poor", because such a multiplier value is usually associated with economically unviable road projects. Gross national road construction multiplier effects with a value of 2,00 or more are associated with economically viable projects. An analysis as referred to above will show that, with a once-off gross income multiplier value of 4,58, the construction of economically viable roads will afford the government a "very good" opportunity to generate income effectively, especially considering that the national economy-wide gross income multiplier in South Africa is 3,27, which shows that the gross income multiplier of road construction is 40% higher than the economy-wide gross income multiplier. The reasons why the once-off gross regional income multiplier stemming from construction expenditure on rural road projects is "very good" are as follows: Multiplier Rating 1 – 1,99 Poor 2 – 2,99 Satisfactory 3 – 3,99 Good 4 – 4,99 Very good < 5 Excellent (1) A substantial proportion of the payroll of road construction workers is subject to zero or low personal income tax rates. (2) The propensity to consume among rural, unskilled and semi-skilled workers (in areas where rural roads are constructed) is generally high, which implies a low savings leakage. (3) Labourers needed for road construction are usually recruited from (or from close by) the areas where a road is to be built. Furthermore, low-income earners tend to buy and consume goods that are produced locally. (4) Generally, there is a relatively small need to import economic resources for road construction projects. Items like timber, sand, stone, gravel, filling material, bitumen, cement, steel and most of the road construction equipment are of regional or, at least, South African origin. The pace at which an economically viable road will stimulate regional income will be reflected by the new traffic it induces and any existing traffic that it diverts from less beneficial roads. In the social cost-benefit analysis of a road, it is estimated by what proportion induced and diverted traffic will increase the road user surplus. This expected proportional increase in road user surplus will accelerate (stimulate) the once-off regional multiplier and is termed the "regional income stimulation factor". Project-driven induced investment activities - i.e. downstream investment activities made possible by the provision of the road - usually (a) involve technically more sophisticated construction projects than the analysed road itself, (b) require the importation of a greater proportion of finished goods and specialised equipment, and (c) involve more skilled and highly skilled workers, whose income is subject to high income tax rates and who exhibit a higher propensity for saving than unskilled workers. Such downstream activities will collectively have a greater leakage effect than that incorporated in the once-off regional multiplier pertaining to construction of the road, which will depress the magnitude of the recurring regional income accelerator. The different formulae used to calculate the recurring income accelerator are detailed in the body of the article.

Hierdie artikel dui aan hoe die eenmalige verhoging in streeksinkome wat uit investeringsbesteding tydens die bou van 'n pad spruit, en die herhalende bykomende streeksinkome wat uit die gebruik van 'n ekonomies geregverdigde nuwe pad spruit, deur onderskeidelik streeksinkomevermenigvuldigerontleding en streeksinkome-versnellerontleding beraam kan word. Om die effek van die streeksinkomevermenigvuldiger van die uitgawe verbonde aan die bou van 'n pad te bepaal, moet (i) die belastings wat by die bou-uitgawe ingesluit is, as 'n verhouding van die totale bou-uitgawe, (ii) die bedrae geld wat deur projekwerkers gespaar word, as 'n verhouding van die totale bou-uitgawe, en (iii) die besteding aan ingevoerde projekinsette, as 'n verhouding van die totale bou-uitgawe, bepaal word. Ontledings wat bogenoemde drie fondslekkasies uit die kringloop van streeksinkome in ag neem, toon dat die verteenwoordigende inkomevermenigvuldiger van Suid-Afrikaanse bouprojekte vir buitestedelike geplaveide paaie 'n waarde van 4,58 het. Op die beoordelingskaal van inkomevermenigvuldigerwaardes vir die bou van buitestedelike paaie bied dit aan die staat 'n "baie goeie" geleentheid om inkome te genereer, veral as in ag geneem word dat die gemiddelde inkomevermenigvuldiger van besteding in die Suid-Afrikaanse ekonomie 'n waarde van 3,27 het. Die formules waarmee die eenmalige inkomevermenigvuldiger beraam word, word in die liggaam van die artikel uiteengesit. Die herhalende versnelde streeksinkome wat uit die gebruik van 'n ekonomies lewensvat-bare pad spruit, is gelyk aan die produk van (a) die huidige waarde van die herhalende pad-gebruikersvoordele wat uit die gebruik van die pad spruit, en (b) die waarde van die streeks-inkomeversneller van die gebruik van die pad. 'n Streeksinkomeversneller wat as verstekwaarde kan dien in die ekonomiese-impakontleding van 'n ekonomies lewensvatbare geplaveide buitestedelike pad in gevalle waar dit nie haalbaar is om 'n projek-eie versneller te probeer beraam nie, word in die artikel bereken. Die formules waarmee die herhalende-inkomeversneller beraam word, word in die liggaam van die artikel uiteengesit.

Resumo Durante a pandemia da COVID-19, boa parte do mundo enfrentou medidas rigorosas de isolamento, incluindo o Chile. Isso implicou que as universidades tivessem que adaptar suas aulas para o ensino a distância. Embora tenham sido conduzidas diversas pesquisas sobre feedback em educação a distância, poucos estudos abordaram o cenário pandêmico. Este estudo investiga o feedback em trabalhos de escrita de nível universitário para estudantes que estão começando suas carreiras em ciências da saúde durante esse período excepcional. Utilizando uma abordagem quantitativa, o estudo envolveu 341 estudantes universitários que responderam a um questionário autoadministrado. A análise dos resultados revelou vários achados importantes: a) o feedback apresentou um processo inicial eficaz, b) os educadores tendem a fornecer menos feedback em etapas intermediárias e c) o feedback continua a se concentrar principalmente em aspectos léxico-gramaticais, refletindo práticas semelhantes às encontradas no ensino presencial.

Abstract Amid the global COVID-19 pandemic, many countries, including Chile, implemented extensive lockdown measures, prompting universities to shift to remote teaching. While there has been substantial research on feedback in online education, few studies have considered the unique challenges posed by the pandemic. This research investigates the provision of feedback on university-level writing assignments for students pursuing medical sciences degrees during this unprecedented period. Using a quantitative approach, the study involved 341 university students who completed a self-administered questionnaire. The analysis of the results revealed several key findings: a) feedback processes had an effective initial phase, b) educators were less likely to provide feedback during intermediate stages, and c) feedback primarily focused on lexical-grammatical aspects, mirroring traditional face-to-face contexts.

Resumen Durante la pandemia, gran parte del mundo se sometió a un confinamiento total, incluyendo a Chile. Esto implicó que las universidades desarrollaran las clases desde los hogares. Aunque se han realizado investigaciones sobre la retroalimentación de la escritura en la educación telemática, estas no han considerado el escenario pandémico. Por ello, este estudio explora la retroalimentación de la escritura universitaria en estudiantes de ciencias médicas durante la pandemia. Con un enfoque cuantitativo, la muestra consideró 341 estudiantes universitarios, a los que se les aplicó un cuestionario autoadministrado. Tras el análisis, los resultados indican lo siguiente: (a) la retroalimentación da cuenta de un proceso inicial eficiente; (b) los profesores no retroalimentarían en instancias intermedias, y (c) la retroalimentación sigue anclada en lo léxico-gramatical, prácticas similares a lo que ocurre en contextos presenciales.

ABSTRACT: The peach palm (Bactrisgasipaes) is an important alternative for heart-of-palm extraction, showing precocity, rusticity and high tillering. The seeds of this species are considered recalcitrant making storage for long periods and production of seedlings difficulty. This identified a combination of moisture content of peach palm seeds and temperature during storage for longer seed longevity. Seeds with 35% and 45% of moisture content (wet basis - wb) were storage at 20 °C and 25 ºC during 180 days. The evaluations were carried out every 60 days by the germination test, emergence in sand, shoot length, diameter of stem, shoot dry matter, root dry matter and moisture content. It was observed that seeds with moisture content of 45% wb showed better performance during storage. The storage at 20 ºC provides higher seed quality maintenance. Peach palm seeds maintain their viability for 120 days when stored with moisture content of 45% wb at 20 ºC. ABSTRACT Bactrisgasipaes (Bactrisgasipaes heartofpalm heart extraction precocity tillering difficulty longevity 35 45 wet 2 C 18 6 test sand length stem maintenance 12 3 4 1

RESUMO: A pupunha (Bactris gasipaes) é uma importante alternativa para a extração de palmito, apresentando precocidade, rusticidade e alto grau de perfilhamento. As sementes desta espécie são consideradas recalcitrantes, dificultando o armazenamento por longos períodos e a produção de mudas. Neste trabalho objetivou-se identificar uma combinação de teor de água das sementes de pupunha e temperatura durante o armazenamento para maior longevidade das sementes. Foram utilizadas sementes com teor de água de 35% e 45% (base úmida - bu), armazenadas a 20 °C e 25 ºC por 180 dias. As avaliações foram realizadas a cada 60 dias, por meio do teste de germinação, emergência em areia, comprimento da parte aérea, diâmetro de coleto, massa de matéria seca de parte aérea, massa de matéria seca de raiz das plantas e teor de água das sementes. Observou-se que as sementes com teor de água de 45% tiveram desempenho superior durante o armazenamento. A temperatura de 20 ºC proporciona maior manutenção da qualidade das sementes. Sementes de pupunha mantêm sua viabilidade durante 120 dias, quando armazenadas com teor de água de 45% a 20 ºC. RESUMO Bactris gasipaes palmito precocidade perfilhamento recalcitrantes mudas objetivouse objetivou se 35 45 base bu, bu , bu) 2 C 18 dias 6 germinação areia aérea coleto Observouse Observou 12 3 4 1

ABSTRACT: This study evaluated the effect of the co-feeding (C) period on the growth and survival of larvae of the yo-yo loach Botia lohachata ornamental species during the weaning period from live food (LF) to inert food (IF). The breeders were subjected to induced spawning using crude pituitary homogenate. A total of 2,400 larvae were used with an average initial weight of 0.39 ± 0.09 mg and an average total length of 4.08 ± 0.21 mm, from a single breeding pair. The live food was newly hatched nauplii of Artemia franciscana, and the inert diet was a commercial ration with 55% crude protein and two particle sizes (142-350 µm and 350-500 µm). As the first food, all larvae received A. franciscana during the first six days, except for the fasting (NC) and inert food (IF) groups. The following co-feeding strategies were employed: C4 = 4 days of co-feeding, C8 = 8 days of co-feeding, C12 = 12 days of co-feeding, and LF = Artemia during the entire experimental period. The longest period with live food promoted better larval growth rates. The specific growth rate of larvae fed live food during the entire period (LF) was higher than that of the other groups, followed by the co-feeding strategies. There was no effect (P > 0.01) on larval survival in the LF, C12, C8, and C4 groups, which ranged from 41% to 53% after 30 days. Treatment R resulted in high mortality and low growth, suggesting that live food should be the first food source for B. lohachata larvae. ABSTRACT cofeeding co feeding C (C yoyo yo (LF IF. IF . homogenate 2400 2 400 2,40 039 0 39 0.3 009 09 0.0 408 08 4.0 021 21 0.2 mm pair 55 142350 142 350 (142-35 350500 500 350-50 µm. µm) NC (NC (IF groups employed cofeeding, feeding, C1 1 rates P 0.01 001 01 41 53 3 B 240 40 2,4 03 0. 00 4. 02 5 14235 14 35 (142-3 35050 50 350-5 24 2, 1423 (142- 3505 350- (142 (14 (1 (

RESUMO: Este estudo teve como objetivo avaliar o efeito do período de co-alimentação (C) no crescimento e sobrevivência de larvas da espécie ornamental Botia lohachata durante o período de desmame de alimento vivo (LF) para alimento inerte (IF). Os reprodutores foram submetidos à desova induzida com homogeneizado de hipófise. Foram utilizadas 2.400 larvas com peso inicial médio de 0,39 ± 0,09 mg e comprimento total médio de 4,08 ± 0,21 mm, de um único casal reprodutor. O alimento vivo foi náuplios recém-eclodidos de Artemia franciscana, e a dieta inerte foi uma ração comercial com 55% de proteína bruta e dois tamanhos de partículas (142-350 µm e 350-500 µm). Como primeiro alimento, todas as larvas receberam A. franciscana durante os primeiros seis dias, exceto os grupos jejum (NC) e alimento inerte (IF). As seguintes estratégias de co-alimentação foram empregadas: C4 = 4 dias de co-alimentação, C8 = 8 dias de co-alimentação, C12 = 12 dias de co-alimentação e LF = Artemia durante todo o período experimental. O maior período com alimento vivo promoveu melhores taxas de crescimento larval. A taxa de crescimento específico das larvas alimentadas com ração viva durante todo o período (LF) foi maior que a dos demais grupos, seguida das estratégias de co-alimentação. Não houve efeito (P > 0,01) na sobrevivência larval nos grupos LF, C12, C8 e C4, que variou de 41% a 53% após 30 dias. O tratamento IN resultou em alta mortalidade e baixo crescimento, sugerindo que o alimento vivo deve ser a primeira fonte de alimento para as larvas de B. lohachata. RESUMO coalimentação co alimentação C (C (LF IF. IF . (IF) hipófise 2400 2 400 2.40 039 0 39 0,3 009 09 0,0 408 08 4,0 021 21 0,2 mm reprodutor recémeclodidos recém eclodidos 55 142350 142 350 (142-35 350500 500 350-50 µm. µm) NC (NC empregadas coalimentação, alimentação, C1 1 experimental coalimentação. alimentação. P 0,01 001 01 41 53 3 B (IF 240 40 2.4 03 0, 00 4, 02 5 14235 14 35 (142-3 35050 50 350-5 24 2. 1423 (142- 3505 350- (142 (14 (1 (

Immature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angiogenin on both hematopoietic stem cells and multipotent progenitors. Treatment with bone marrow cells of experimental mice with these preparations stimulates colony formation by hematopoietic stem cells and proliferation of multipotent descendants. The main lineage responsible for this is the granulocyte-macrophage hematopoietic lineage. Using fluorescent microscopy as well as FACS assay, co-localization of primitive c-Kit- and Sca-1-positive progenitors and the TAMRA-labeled double-stranded DNA has been shown. Human recombinant angiogenin was used as a reference agent. Cells with specific markers were quantified in intact bone marrow and colonies grown in the presence of inducers. Quantitative analysis revealed that a total of 14,000 fragment copies of 500 bp, which is 0.2% of the haploid genome, can be delivered into early progenitors. Extracellular double-stranded DNA fragments stimulated the colony formation in early hematopoietic progenitors from the bone marrow, which assumed their effect on cells in G0. The observed number of Sca1+/c-Kit+ cells in colonies testifies to the possibility of both symmetrical and asymmetrical division of the initial hematopoietic stem cell and its progeny. apparatus doublestranded double stranded shown research DNAgr, DNAgr , (DNAgr) DNAmix descendants granulocytemacrophage granulocyte macrophage assay colocalization co localization cKit c Kit c-Kit Sca1positive Scapositive Sca 1 positive TAMRAlabeled TAMRA labeled agent inducers 14000 14 000 14,00 50 bp 02 0 2 0.2 G0 G Sca1+/cKit+ Sca1cKit ScacKit Sca1+/c Kit+ Sca1 Sca1+/c-Kit progeny (DNAgr 1400 00 14,0 5 0. Sca1+/cKit Sca1c Scac 140 14,

Resumen Objetivo Mapear la producción científica sobre las estrategias educativas y los contenidos abordados en la educación de personas que viven con el VIH. Métodos Esta es una revisión de alcance, cuya selección de artículos se realizó en abril de 2021 y se actualizó en octubre de 2022 en diez fuentes de datos. La revisión siguió las premisas establecidas por el Joanna Briggs Institute y la checklist de los Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. Los resultados fueron analizados descriptivamente y sintetizados en un cuadro. Resultados Se seleccionaron 17 estudios con publicación predominante en 2017. Estados Unidos de América y Brasil fueron los países con mayor cantidad de producciones. La mayoría de los estudios buscó evaluar el impacto y la eficacia de las estrategias y elaborar o validar instrumentos de educación para la salud y actividades de prevención. Con relación al contenido abordado por las estrategias, se formaron cinco categorías: instrucciones iniciales sobre VIH/SIDA, cuidados generales, vida saludable, salud sexual y apoyo emocional. Las estrategias educativas que se destacaron con relación a una mayor adhesión de los pacientes al tratamiento están relacionadas con el desarrollo de sistemas, programas y multimedia. Las cartillas promovieron empoderamiento y autonomía de personas que viven con el VIH. Conclusión Se mapearon las principales estrategias educativas, con énfasis en cartillas, material impreso, recursos multimedia, sistemas, formularios y talleres/workshops, que abordaron instrucciones iniciales sobre VIH/SIDA, tratamiento farmacológico, cuidados generales, vida saludable, salud sexual y apoyo social y emocional. Open Science Framework (OSF): https://osf.io/754uk/?view_only=6491865a3d12424d81af2c4099c112c3 VIH alcance 202 datos MetaAnalyses Meta Analyses Reviews cuadro 1 2017 producciones prevención categorías VIHSIDA SIDA VIH/SIDA generales saludable emocional sistemas multimedia impreso talleresworkshops talleres workshops talleres/workshops farmacológico OSF (OSF) https//osf.io/754uk/view_only=6491865a3d12424d81af2c4099c112c3 httpsosfio754ukviewonly6491865a3d12424d81af2c4099c112c3 httpsosfioukviewonlyaddafccc https //osf.io/754uk/ view_only=6491865a3d12424d81af2c4099c112c3 osf io 754uk view only 6491865a3d12424d81af2c4099c112c3 uk d af c https://osf.io/754uk/?view_only=6491865a3d12424d81af2c4099c112c 20 201 (OSF https//osf.io/754uk/view_only=6491865a3d12424d81af2c4099c112c httpsosfio ukviewonly httpsosfio754ukviewonly6491865a3d12424d81af2c4099c112c osfio754uk osfiouk //osf.io/754uk viewonly6491865a3d12424d81af2c4099c112c3 viewonlyaddafccc view_only=6491865a3d12424d81af2c4099c112c addafccc 6491865a3d12424d81af2c4099c112c 2 osfio viewonly viewonly6491865a3d12424d81af2c4099c112c

Abstract Objective To map the scientific production on educational strategies and the content covered in the education of people living with HIV. Methods This is a scoping review in which the selection of articles was carried out in April 2021 and updated in October 2022 in ten data sources; the review followed the assumptions established by the Joanna Briggs Institute and the checklist of Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. The results were descriptively analyzed and summarized in a chart. Results A total of 17 studies were selected, predominantly published in 2017; The USA and Brazil were the countries with the largest number of productions. Most studies sought to evaluate the impact and effectiveness of strategies and develop or validate health education instruments and prevention activities. Concerning the content covered by the strategies, five categories were formed: initial guidance on HIV/AIDS, general care, healthy living, sexual health, and emotional support. The educational strategies that stood out concerning greater patient adherence to treatment are related to the development of systems, programs, and multimedia. The booklets promoted empowerment and autonomy for people living with HIV. Conclusion The main educational strategies were mapped, with emphasis on booklets, printed material, multimedia resources, systems, forms, and workshops, covering initial guidance on HIV/AIDS, pharmacological treatment, general care, healthy living, sexual health, and social and emotional support. Open Science Framework (OSF): https://osf.io/754uk/?view_only=6491865a3d12424d81af2c4099c112c3 HIV 202 sources MetaAnalyses Meta Analyses Reviews chart 1 selected 2017 productions activities formed HIVAIDS AIDS HIV/AIDS care support systems programs mapped material resources forms workshops OSF (OSF) https//osf.io/754uk/view_only=6491865a3d12424d81af2c4099c112c3 httpsosfio754ukviewonly6491865a3d12424d81af2c4099c112c3 httpsosfioukviewonlyaddafccc https //osf.io/754uk/ view_only=6491865a3d12424d81af2c4099c112c3 osf io 754uk view only 6491865a3d12424d81af2c4099c112c3 uk d af c https://osf.io/754uk/?view_only=6491865a3d12424d81af2c4099c112c 20 201 (OSF https//osf.io/754uk/view_only=6491865a3d12424d81af2c4099c112c httpsosfio ukviewonly httpsosfio754ukviewonly6491865a3d12424d81af2c4099c112c osfio754uk osfiouk //osf.io/754uk viewonly6491865a3d12424d81af2c4099c112c3 viewonlyaddafccc view_only=6491865a3d12424d81af2c4099c112c addafccc 6491865a3d12424d81af2c4099c112c 2 osfio viewonly viewonly6491865a3d12424d81af2c4099c112c

Resumo Objetivo Mapear a produção científica sobre as estratégias educativas e os conteúdos abordados na educação de pessoas vivendo com HIV. Métodos Esta é uma revisão de escopo em que a seleção dos artigos foi realizada em abril de 2021 e atualizada em outubro de 2022 em dez fontes de dados; a revisão seguiu os pressupostos estabelecidos pelo Joanna Briggs Institute e o checklist dos Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. Os resultados foram analisados descritivamente e sintetizados em um quadro. Resultados Foram selecionados 17 estudos com publicação predominante em 2017; Estados Unidos da América e Brasil foram os países com a maior quantidade de produções. A maioria dos estudos buscou avaliar o impacto e a eficácia das estratégias e desenvolver ou validar instrumentos de educação em saúde e atividades de prevenção. Em relação ao conteúdo abordado pelas estratégias, foram formadas cinco categorias: orientação inicial sobre HIV/AIDS, cuidados gerais, vida saudável, saúde sexual e suporte emocional. As estratégias educativas que se destacaram em relação à maior adesão dos pacientes ao tratamento estão relacionadas com o desenvolvimento de sistemas, programas e multimídia. As cartilhas promoveram empoderamento e autonomia de pessoas vivendo com HIV. Conclusão Foram mapeadas as principais estratégias educativas, com destaque para cartilhas, material impresso, recursos multimídia, sistemas, formulários e oficinas/workshops, abordando orientação inicial sobre HIV/AIDS, tratamento farmacológico, cuidados gerais, vida saudável, saúde sexual e suportes social e emocional. HIV 202 dados MetaAnalyses Meta Analyses Reviews quadro 1 2017 produções prevenção categorias HIVAIDS AIDS HIV/AIDS gerais saudável emocional sistemas multimídia impresso oficinasworkshops oficinas workshops oficinas/workshops farmacológico 20 201 2

ABSTRACT Gliricidia (Gliricidia sepium (Jacq) Kunth ex Walp) is a legume that has been used in agroforestry systems, for animal feed and contribution to soil fertility. During the cultivation of the crop, it is necessary to carry out weed management, as these can interfere with the growth and development of gliricidia, and it is essential to know the competitive ability of the crop with weeds. In view of the above, the objective was to evaluate the competitiveness of gliricidia coexisting with the weeds Senna obtusifolia(sicklepod), Commelina benghalensis(benghal dayflower), Bidens subalternans(beggarticks), Ipomoea triloba(morning glory) and Urochloa brizantha(signalgrass). The experiment was set up in a greenhouse, in a completely randomized design, with four replications. Each experimental unit consisted of a pot containing a gliricidia seedling in coexistence with three weeds of each species, in addition to the monoculture of the six species, as a comparison standard. The initial growth of gliricidia seedlings and weeds was evaluated through stem diameter, plant height, counting the number of leaves; root volume; and dry matter of leaves, stem and root. The data were submitted to analysis of variance (p<0.05) and when significant, the means were compared using the Tukey test. The competition of gliricidia with weeds resulted in a reduction in the increment of all analyzed variables. The results obtained showed that all weeds, with the exception of C. benghalensis, interfered negatively in the growth of the tree species. Jacq (Jacq Walp systems fertility management above obtusifoliasicklepod, obtusifoliasicklepod obtusifolia sicklepod , obtusifolia(sicklepod) benghalensisbenghal benghalensis benghal dayflower, dayflower dayflower) subalternansbeggarticks, subalternansbeggarticks subalternans beggarticks subalternans(beggarticks) trilobamorning triloba morning glory brizanthasignalgrass. brizanthasignalgrass brizantha signalgrass . brizantha(signalgrass) greenhouse design replications species standard diameter height leaves volume p<0.05 p005 p 0 05 (p<0.05 significant test variables C obtusifolia(sicklepod subalternans(beggarticks brizantha(signalgrass p<0.0 p00 (p<0.0 p<0. p0 (p<0. p<0 (p<0 p< (p< (p

RESUMO A gliricídia (Gliricidia sepium(Jacq) Kunth ex Walp) é uma leguminosa que vem sendo utilizada em sistemas agroflorestais, visando alimentação animal e contribuição na fertilidade do solo. Durante o seu cultivo é necessária a realização do manejo de plantas daninhas, pois essas podem interferir no crescimento e no desenvolvimento da gliricídia, sendo fundamental conhecer a habilidade competitiva da cultura com as plantas daninhas. Diante do exposto, este trabalho teve como objetivo avaliar a competitividade da gliricídia convivendo com as plantas daninhas Senna obtusifolia(fedegoso), Commelina benghalensis (trapoeraba), Bidens subalternans (picão-preto), Ipomoea triloba(corda-de-viola) e Urochloa brizantha(braquiária). O experimento foi montado em casa de vegetação, em delineamento inteiramente casualizado, com quatro repetições. Cada unidade experimental foi composta por um vaso contendo uma muda de gliricídia em convivência com três plantas daninhas de cada espécie, e o monocultivo das seis espécies, como padrão de comparação. Foi avaliado o crescimento inicial das mudas de gliricídia e das plantas daninhas através do diâmetro do caule, altura da planta e contagem do número de folhas; volume de raiz; massa da matéria seca das folhas, do caule e da raiz. Os dados foram submetidos à análise de variância (p<0,05) e quando significativas, as médias foram comparadas pelo teste de Tukey. A competição da gliricídia com as plantas daninhas resultou na redução de todas as variáveis analisadas. Os resultados obtidos comprovaram que todas as plantas daninhas, com exceção de C. benghalensis, interferiram negativamente no crescimento da espécie arbórea. Gliricidia sepiumJacq sepium Jacq sepium(Jacq Walp agroflorestais solo exposto obtusifoliafedegoso, obtusifoliafedegoso obtusifolia fedegoso , obtusifolia(fedegoso) trapoeraba, trapoeraba (trapoeraba) picãopreto, picãopreto picão preto (picão-preto) trilobacordadeviola triloba corda viola triloba(corda-de-viola brizanthabraquiária. brizanthabraquiária brizantha braquiária . brizantha(braquiária) vegetação casualizado repetições espécies comparação folhas raiz p<0,05 p005 p 0 05 (p<0,05 significativas Tukey analisadas C arbórea obtusifolia(fedegoso (trapoeraba (picão-preto brizantha(braquiária p<0,0 p00 (p<0,0 p<0, p0 (p<0, p<0 (p<0 p< (p< (p

ABSTRACT Hepatitis C virus infection may be implicated in 12.7% of ocular adnexal marginal zone lymphomas. We present the first case of an orbital-systemic mucosa-associated lymphoid tissue lymphoma that responded to hepatitis C virus medical treatment. A 62-year-old male with a right-sided orbital mass was diagnosed with stage IIA orbital marginal zone lymphoma in addition to hepatitis C virus infection based on clinical, imaging, laboratory, and histological examinations. The systemic and orbital responses were achieved 1 year after undergoing hepatitis C virus treatment with glecaprevir/pibrentasvir. The association between the hepatitis C virus infection and orbital-systemic mucosa-associated lymphoid tissue lymphoma is relevant. Accordingly, patients with orbital mucosa-associated lymphoid tissue lymphoma should be assessed for hepatitis C virus seroreactivity for therapeutic and prognostic purposes. 127 12 7 12.7 lymphomas orbitalsystemic mucosaassociated mucosa associated 62yearold yearold 62 old rightsided right sided clinical imaging laboratory examinations glecaprevirpibrentasvir glecaprevir pibrentasvir glecaprevir/pibrentasvir relevant Accordingly purposes 12. 6

Abstract: This study evaluated the stress distribution in the dentoalveolar and palatal bone structures during maxillary expansion in a 17-year-old male patient with bilateral cleft lip and palate (BCLP) using expanders with dental (HYRAX) and skeletal anchorage (MARPE). For the generation of the specific finite element models, cone-beam computed tomography was used, and the DICOM files were exported to Mimics 3-Matic (Materialise) and Patran (MSC Software) software. Three specific three-dimensional models were generated: A) HYRAX: conventional four-banded hyrax screw (9 mm); B) MARPE-DS: 3 miniscrews (1.8 mm diameter – 5.4 mm length) and four-banded dental anchorage; and C) MARPE-NoDS: 3 miniscrews without dental anchorage. Maxillary expansion was simulated by activating the expanders transversely 1 mm on the "X" axis. HYRAX resulted in higher levels of deformation predominantly in the dentoalveolar region. MARPE-DS showed stress in the dentoalveolar region and mainly in the center of the palatal region, at approximately 4,000 με. MARPE-NoDS exhibited evident stress only in the palatal region. High stress levels in the root anchoring teeth were observed for HYRAX and MARPE-DS. In contrast, MARPE-NoDS cause stress on the tooth structure. The stress distribution from the expanders used in the BLCP showed asymmetric expansive behavior. During the initial activation phase of expansion, the HYRAX and MARPE-DS models produced similarly high strain at the dentoalveolar structures and upper posterior teeth displacement. The MARPE-NoDS model showed restricted strain on the palate. Abstract 17yearold yearold 17 year old BCLP (BCLP (HYRAX MARPE. MARPE . (MARPE) conebeam cone beam 3Matic Matic Materialise (Materialise MSC Software software threedimensional three dimensional generated A fourbanded four banded 9 ( mm) B MARPEDS DS 1.8 18 8 (1. 54 5 4 5. length C MARPENoDS NoDS X "X axis 4000 000 4,00 με MARPEDS. DS. contrast structure behavior displacement (MARPE 1. (1 400 00 4,0 40 0 4,