Résumé Par la méthode historique-comparative, cet article aborde les impacts, sur les États-Unis, l’Allemagne et le Brésil, des quatre crises économiques internationales survenues jusqu’en 2019, en se concentrant principalement sur leurs effets sur le régime politique et le post-2008. Les pays sélectionnés ont eu des expériences autoritaires distinctes, anciennes ou actuelles. Je conceptualise l’État de manière tridimensionnelle : régime politique, appareil décisionnel et structure de domination politique appuyée sur des coalitions. J’argumente que les conjonctures internationales critiques ont tendance à avoir un impact sur cette tridimensionalité, facilitant l’observation de ses variations et continuités. Je formule et corrobore trois hypothèses sur ces crises : elles ont tendance à augmenter ou diminuer les niveaux de démocratie ou d’autocratie des régimes ou à les changer ; la réponse autocratisante dépend d’une relation de forces pro-entreprises, subordonnant les travailleurs ; l’engagement démocratique des acteurs s’oppose à l’autocratisation. La contribution à la littérature réside dans la manière d’aborder les processus d’autocratisation et de démocratisation, ici étudiés à travers les impacts des crises économiques internationales sur les États. Les conjonctures critiques éclairent les composants clés de la mutabilité du Léviathan. On examine le régime politique par la politique économique des relations entre l’État, les marchés et les classes sociales, et non exclusivement par les variables politico-institutionnelles. On analyse les mécanismes d’intersection de la sphère et des acteurs politico-institutionnels avec les structures et acteurs économiques et sociaux, qui, impactant la tridimensionalité de l’État, entraînent des changements de régime ou dans le régime. historiquecomparative, historiquecomparative historique comparative, comparative historique-comparative ÉtatsUnis, ÉtatsUnis États Unis, Unis États-Unis lAllemagne l Allemagne Brésil jusquen jusqu 2019 post2008. post2008 post 2008. 2008 post-2008 distinctes actuelles lÉtat État coalitions Jargumente J argumente lobservation observation continuités dautocratie d autocratie dune une proentreprises, proentreprises pro entreprises, entreprises pro-entreprises lengagement engagement soppose s oppose lautocratisation. lautocratisation autocratisation. autocratisation l’autocratisation daborder aborder dautocratisation démocratisation Léviathan lÉtat, État, sociales politicoinstitutionnelles. politicoinstitutionnelles politico institutionnelles. institutionnelles politico-institutionnelles dintersection intersection politicoinstitutionnels institutionnels sociaux qui 201 post200 200 post-200 20 post20 post-20 2 post2 post-2 post-

Resumen Por medio del método histórico comparativo, se abordan los impactos en los Estados de Estados Unidos, Alemania y Brasil, de las cuatro crisis económicas internacionales que han ocurrido hasta 2019, enfocándose, principalmente, en sus efectos en el régimen político y en el periodo posterior a 2008. Los países seleccionados tuvieron distintas experiencias autoritarias, antiguas o actuales. Defino al Estado de una forma tridimensional: régimen político, aparato decisor y estructura de dominación política respaldada en coaliciones. Argumento que las respectivas coyunturas críticas internacionales tienden a impactar esta tridimensionalidad, facilitando la observación de sus variaciones y continuidades. Así, formulo y corroboro tres hipótesis sobre esas crisis: tienden a aumentar o disminuir los niveles de democracia o autocracia de los regímenes o a cambiarlos; la respuesta autocratizante depende de una relación de fuerzas proempresarial que subordina a los trabajadores; y el compromiso democrático de los actores opera contra la autocratización. La contribución a la literatura se relaciona con el modo de abordar los procesos de autocratización y democratización aquí investigados por los impactos de las crisis económicas internacionales en los Estados. Las coyunturas críticas vislumbran componentes clave de la mutabilidad del Leviatán. Se investiga el régimen político a partir de la economía política de las relaciones entre Estado, mercados y clases sociales, y no exclusivamente por las variables político-institucionales. Se analizan mecanismos de intersección de la esfera y de los actores político-institucionales con las estructuras y actores económicos y sociales, que, impactando en la tridimensionalidad del Estado, implican cambios de régimen o en el régimen. comparativo Unidos Brasil 2019 enfocándose principalmente 2008 autoritarias actuales tridimensional coaliciones continuidades Así cambiarlos trabajadores Leviatán sociales políticoinstitucionales. políticoinstitucionales institucionales. institucionales 201 200 20 2

Abstract This study uses a historical-comparative method to examine the impacts of the four international economic crises that occurred until 2019 on the United States, Germany, and Brazil, focusing primarily on their effects on the political regime and the post-2008 period. The selected countries had different authoritarian experiences, either in the distant past or more recently. The State is conceptualized along three dimensions: political regime, decision-making apparatus, and the structure of political domination supported by coalitions. The argument is that the respective international critical junctures tend to impact this three-dimensionality, making it easier to observe their variations and continuities. Three hypotheses are formulated and corroborated regarding these crises: they tend to increase or decrease the levels of democracy or autocracy in regimes or change them; autocratization depends on a pro-business power balance that subordinates workers; the democratic commitment of actors operates against autocratization. This study’s contribution to the literature lies in the approach to processes of autocratization and democratization, which are investigated here through the impacts of international economic crises on States. Critical junctures shed light on key components of the mutability of the Leviathan. It investigates the political regime through the political economy of the relationships between the State, markets, and social classes, not exclusively through political-institutional variables. Mechanisms of intersection between the political-institutional sphere and economic and social structures and actors are analyzed. These mechanisms impact the three-dimensionality of the State, leading to changes in the regime or within the regime. historicalcomparative historical comparative 201 States Germany Brazil post2008 post 2008 post-200 period experiences recently dimensions decisionmaking decision apparatus coalitions threedimensionality, threedimensionality dimensionality, dimensionality continuities them probusiness pro business workers studys s democratization Leviathan markets classes politicalinstitutional institutional variables analyzed 20 post200 200 post-20 2 post20 post-2 post2 post-

Resumo Aborda-se, pelo método histórico-comparativo, impactos, nos Estados dos EUA, Alemanha e Brasil, das quatro crises econômicas internacionais ocorridas até 2019, focando-se, principalmente, em seus efeitos no regime político e no pós-2008. Os países selecionados tiveram distintas experiências autoritárias, remotas ou atuais. Conceituo o Estado tridimensionalmente: regime político, aparato decisor e estrutura de dominação política escorada em coalizões. Argumento que as respectivas conjunturas críticas internacionais tendem a impactar nesta sua tridimensionalidade, facilitando a observação de suas variações e continuidades. Formulo e corroboro três hipóteses sobre essas crises: elas tendem a aumentar ou diminuir os níveis de democracia ou autocracia dos regimes ou a mudá-los; a resposta autocratizante depende de uma relação de forças pró-empresarial, que subordine os trabalhadores; o compromisso democrático dos atores opera contra a autocratização. A contribuição com a literatura está no modo de abordagem dos processos de autocratização e democratização, aqui investigados pelos impactos das crises econômicas internacionais nos Estados. As conjunturas críticas iluminam componentes-chave da mutabilidade do Leviatã. Investiga-se o regime político pela economia política das relações entre Estado, mercados e classes sociais, e não exclusivamente pelas variáveis político-institucionais. Analisam-se mecanismos de intersecção da esfera e dos atores político-institucionais com as estruturas e atores econômicos e sociais, que, impactando na tridimensionalidade do Estado, ensejam mudanças de regime ou no regime. Abordase, Abordase Aborda se, se Aborda-se históricocomparativo, históricocomparativo histórico comparativo, comparativo histórico-comparativo EUA Brasil 2019 focandose, focandose focando focando-se principalmente pós2008. pós2008 pós 2008. 2008 pós-2008 autoritárias atuais tridimensionalmente coalizões continuidades mudálos mudá los mudá-los próempresarial, próempresarial pró empresarial, empresarial pró-empresarial trabalhadores democratização componenteschave componentes chave Leviatã Investigase Investiga sociais políticoinstitucionais. políticoinstitucionais institucionais. institucionais Analisamse Analisam 201 pós200 200 pós-200 20 pós20 pós-20 2 pós2 pós-2 pós-

Résumé Les Indiens, en particulier ceux issus de ce qui était alors compris comme “métissage” ou “miscegenèse” avec des blancs et des noirs, sont devenus un élément clé dans la théorie du médecin et anthropologue Raimundo Nina Rodrigues. Habituellement, son héritage intellectuel est lié à la population “africo-bahianaise”, compte tenu de ses études détaillées sur l’ethnologie urbaine. Cet article cherche à explorer, parmi ses propositions, le rôle du “brasílio-guarany” et son impact négatif sur le développement du pays, selon une perspective scientifique. Nina Rodrigues a engagé un dialogue avec deux auteurs de renom du XIXe siècle sur les Amérindiens du Nord du pays (en particulier au Pará et en Amazonie), José Veríssimo et Couto de Magalhães. Nous soutenons que le résultat de cette confrontation d’idées est un exemple frappant de la manière dont le médecin maranhense a opéré un certain déplacement par rapport au racisme scientifique, dont il s’éloigne (mais n’abandonne pas), en incorporant des éléments de l’évolutionnisme social et en créant une lecture unique des relations sociales et biologiques entre les trois races constitutives de la nation. Indiens métissage “métissage miscegenèse “miscegenèse noirs Habituellement africobahianaise, africobahianaise africo bahianaise , “africo-bahianaise” lethnologie l ethnologie urbaine explorer propositions brasílioguarany brasílio guarany “brasílio-guarany scientifique Amazonie, Amazonie Amazonie) Magalhães didées d idées séloigne s éloigne mais nabandonne n abandonne pas, pas pas) lévolutionnisme évolutionnisme nation “africo-bahianaise

Resumo Los indios, en especial aquellos provenientes de lo que entonces era entendido como “mestizaje” o “mestización” con blancos y negros, se convierten en un factor clave en el plano teórico del médico y antropólogo Raimundo Nina Rodrigues. Habitualmente, su herencia intelectual es vinculada a la población “afro-bahiana”, teniendo em cuenta sus estudios detallados sobre etnología urbana. Este artículo busca explorar, entre sus propuestas, el papel del “brasílio-guarany” y su factor nocivo para el desarrollo del país, desde una perspectiva científica. Nina Rodrigues abrió el diálogo con dos autores destacados en el siglo XIX sobre los amerindios del Norte del país (en especial Pará y Amazonas), José Veríssimo y Couto de Magalhães. Sostenemos que el resultado de esta confrontación de ideas es un ejemplo contundente de cómo el médico marañense hizo un cambio en su posición frente al racismo científico, del cual se distancia (pero no abandona), incorporando elementos del evolucionismo social y creando una lectura única de las relaciones sociales y biológicas entre las llamadas tres razas formadoras de la nación. indios mestizaje “mestizaje mestización “mestización negros Habitualmente afrobahiana, afrobahiana afro bahiana , “afro-bahiana” urbana explorar propuestas brasílioguarany brasílio guarany “brasílio-guarany científica Amazonas, Amazonas Amazonas) Magalhães científico pero abandona, abandona abandona) nación “afro-bahiana

Abstract Indians, especially those who came from what was then understood as mestiçagem or miscegenation with whites and blacks, became a key factor in the theoretical framework of physician and anthropologist Raimundo Nina Rodrigues. Typically, his intellectual heritage is linked to the “African-Bahian” population, given his detailed studies on urban ethnology. This article seeks to explore among his proposals the role of “Brasílio-Guarany” and its perceived harmful impact on the country’s development from a scientistic perspective. Nina Rodrigues engaged in a dialogue regarding Brazil’s Indians from the country’s Northern region (especially Pará and Amazonas) with two prominent nineteenth-century authors: José Veríssimo and Couto de Magalhães. We argue that the result of this clash of ideas is a striking example of how the Maranhão-born doctor underwent a shift in his position regarding scientific racism, from which he distances himself (but does not entirely abandon), incorporating elements of social evolutionism and creating a unique interpretation of the social and biological relations among the so-called three races shaping the nation. blacks Typically AfricanBahian African Bahian “African-Bahian population ethnology BrasílioGuarany Brasílio Guarany “Brasílio-Guarany countrys country s perspective Brazils Brazil Amazonas nineteenthcentury nineteenth century authors Magalhães Maranhãoborn Maranhão born racism but abandon, abandon , abandon) socalled so called nation

Resumo Os índios, em especial aqueles provindos do que então era entendido como “mestiçagem” ou “miscigenação” com brancos e negros, tornaram-se um fator-chave no plano teórico do médico e antropólogo Raimundo Nina Rodrigues. Habitualmente, sua herança intelectual é vinculada à população “áfrico-bahiana”, posto seus estudos detalhados sobre etnologia urbana. Este artigo busca explorar, dentre suas propostas, o papel do “brasílio-guarany” e seu fator nocivo para o desenvolvimento do país, na ótica cientificista. Nina Rodrigues abriu diálogo com dois autores de destaque no século XIX sobre os ameríndios do Norte do país (em especial Pará e Amazonas), José Veríssimo e Couto de Magalhães. Sustentamos que o resultado deste confronto de ideias é um exemplo contundente de como o médico maranhense realizou certo deslocamento de sua posição em face do racismo científico, do qual ele se afasta (mas não abandona), incorporando elementos do evolucionismo-social e criando uma leitura única das relações sociais e biológicas entre as chamadas três raças formadoras da nação. índios mestiçagem “mestiçagem miscigenação “miscigenação negros tornaramse tornaram fatorchave chave Habitualmente áfricobahiana, áfricobahiana áfrico bahiana , “áfrico-bahiana” urbana explorar propostas brasílioguarany brasílio guarany “brasílio-guarany cientificista Amazonas, Amazonas Amazonas) Magalhães científico mas abandona, abandona abandona) evolucionismosocial evolucionismo social nação “áfrico-bahiana

EFFECT OF LIQUID SWINE WASTEWATER DOSES ON PHYSICAL, CHEMICAL AND ELECTROCHEMICAL ATTRIBUTES IN A CERRADO OXISOL. The addition of organic residues enhances soil and plant organic matter and nutrient content. To gauge the impact of varying liquid swine waste (LSW) levels on soil, we studied changes in a clayey Oxisol’s physical, chemical, and electrochemical traits from the Cerrado. LSW doses (0, 50, 150, 450, 600 m3 ha−1) were applied to the 0-0.20 m layer in a randomized design with three replicates. Post a 30-day incubation at 60% field capacity, the soil underwent mineralogical, physical (clay dispersed in water - CDW), chemical (sodium adsorption ratio - SAR, cation exchange capacity - CEC, base saturation - V%), and electrochemical (pH in H2O and KCl, ApH, point of zero charge - PZC, point of zero salt effect - PZSE, surface electric potential - iµo, and electrical conductivity - EC) analyses. The levels of exchangeable Ca, K, Mg, Na, and available P increased with increasing LSW doses. Increasing LSW doses in the soil led to an increase in EC, but soil salinization was not observed at the highest dose. With the application of LSW doses, there was a decrease in pH, ApH, PZSE, and an increase in CEC, PZC and ψo. Despite the increase in ψo, low clay dispersibility was observed. PHYSICAL OXISOL content (LSW Oxisols Oxisol s Cerrado 0, 0 (0 50 150 450 60 ha−1 ha1 ha 1 00.20 0020 0.20 20 0-0.2 replicates 30day day 30 mineralogical CDW, CDW , CDW) sodium SAR CEC V%, V V% V%) pH HO H O KCl ApH PZSE iµo EC analyses Ca K Mg Na dose ψo ( 5 15 45 6 ha− 00 00.2 002 020 0.2 2 0-0. 3 4 00. 02 0. 0-0 0-

Gold and platinum bimetallic nanoparticles, Au@PtNPs, have gained attention due to their plasmonic properties. The controlled synthesis of Au@PtNPs involves complex parameters, and the resulting synergy between Au and Pt introduces possibilities for tailoring their properties. This study explores the effects of key-parameters of synthesis (gold core diameters, reaction time, and Pt concentration) on the final properties of Au@PtNPs. Gold nanoparticles of varying diameters were synthesized and used as cores for the reduction of hexachloroplatinic acid, forming a surrounding shell of Pt nanoparticles. The parameters were systematically tuned to understand their impact on morphology, dimension, stability, and plasmonic properties of Au@PtNPs. Increasing Pt precursor concentration resulted in thicker and denser Pt shells, broadening the localized surface plasmon resonance (LSPR) band and improving Au@PtNPs stability. These properties are essential for applications such as photothermal treatment. The synthesis achieved satisfactory products within just 1 h of Pt4+ reduction at mild temperature without using surfactants. Only limited changes in plasmonic properties were observed after 4 h of synthesis, suggesting an optimal reaction period. Manipulating Au core diameter provided LSPR band control, with smaller cores exhibiting greater broadening towards the infrared region. This systematic exploration provided valuable insights for understanding key-parameters governing the synthesis and properties of Au@PtNPs. AuPtNPs PtNPs keyparameters key gold time acid morphology dimension stability shells (LSPR treatment Pt4 surfactants period control region

The increase in the average temperature of the Earth due to excess CO2 and other greenhouse gases has caused glaciers to melt and sea levels to rise. The burning of fossil fuels is one of the main causes of this problem, so the use of biofuels is important for mitigating this environmental impact. In Brazil, biodiesel is mixed with mineral; however, irregularities have been detected, reducing the expected positive effects. Therefore, this study proposes the use of multivariate curve resolution with alternating least squares (MCR ALS) to quantify the content of methyl palm oil biodiesel in diesel blends and determine the concentration of the adulterant automotive lubricating oil in the blend. The model for quantifying biodiesel in diesel obtained R2 = 0.9997, root mean square error of calibration (RMSEC) = 0.56% (v v-1) and prediction (RMSEP) = 0.65% (v v-1), while the determination of adulteration in the biodiesel-diesel blend showed RMSEC = 0.67% (v v-1), RMSEP = 0.81% (v v-1) and R2 = 0.9992. These results demonstrate the ability of the models developed to predict both the content and quantity of possible adulterants in blends of palm oil biodiesel and mineral diesel, contributing to the quality control of this fuel. CO rise problem impact Brazil however detected effects Therefore MCR ALS R 09997 0 9997 0.9997 (RMSEC 056 56 0.56 v v1 1 v-1 (RMSEP 065 65 0.65 v1, , biodieseldiesel 067 67 0.67 081 81 0.81 09992 9992 0.9992 fuel 0999 999 0.999 05 5 0.5 v- 06 6 0.6 08 8 0.8 099 99 0.99 0. 09 9 0.9

The rapid advance of nanotechnology has led to the proliferation of a wide range of water-soluble nanomaterials and therefore, a profound impact on the environment, underscoring the need to devise effective methods for isolating and confining these nanomaterials. This study presents the development of a highly effective system capable of removing and storing gold nanoparticles in solution using modified resins with different linking groups, such as tris(2-aminoethyl) amine, 3-mercaptopropionic acid, 11-mercaptoundecanoic acid, and L-cysteine. The catalytic properties of the resins functionalized with the thiol group containing gold nanoparticles were evaluated, using the reduction of the nitro compounds (3,5-dinitrosalicylic acid, 4-nitroguaiacol and 4-nitroaniline) as model reaction. Solid-phase organic synthesis was employed to prepare the modified resins and their interaction with gold nanoparticles was characterized using infrared spectroscopy, thermogravimetric analysis, field emission scanning electron microscopy-energy dispersive spectroscopy, and X-ray photoelectron spectroscopy. The removal capacity of the resins was evaluated using ultraviolet-visible optical emission spectroscopy and inductively coupled plasma techniques. Ultraviolet-visible technique was suitable to assess the catalytic properties of the functionalized resins containing gold nanoparticles. It was determined that the functionalized resins showed remarkable capacity for complex gold nanoparticles, removing them from the solution. The most significant removal was with 11-mercaptoundecanoic acid. watersoluble water soluble therefore environment groups tris2aminoethyl trisaminoethyl tris 2 aminoethyl tris(2-aminoethyl amine 3mercaptopropionic mercaptopropionic 3 acid 11mercaptoundecanoic mercaptoundecanoic 11 Lcysteine. Lcysteine L cysteine. cysteine L-cysteine 3,5dinitrosalicylic 35dinitrosalicylic dinitrosalicylic 3,5 5 4nitroguaiacol nitroguaiacol 4 4nitroaniline nitroaniline 4-nitroaniline reaction Solidphase Solid phase analysis microscopyenergy microscopy energy Xray X ray ultravioletvisible ultraviolet visible techniques Ultravioletvisible Ultraviolet 1 5dinitrosalicylic 35 3,

RESUMO Objetivo: Reconhecer e abordar a síndrome de Patau, apesar de sua raridade e da baixa expectativa de vida associada, por meio da apresentação de um estudo de caso de uma paciente de dois anos que recebe cuidados em casa por intermédio de serviços de home care. Descrição do caso: Apresentamos uma paciente do sexo feminino que desafiou as probabilidades, com sobrevivência prolongada devida, possivelmente, ao home care. Ela nasceu por cesariana, com 31 semanas + 4 dias, em razão da restrição do crescimento uterino. A mãe, de 36 anos, recebeu cuidados pré-natais adequados e gozava de boa saúde. O diagnóstico da síndrome de Patau foi confirmado por meio de cariótipo após o nascimento. Apesar da gravidade clínica do caso, a paciente, hoje com dois anos, recebe atendimento domiciliar especializado, apoiado por traqueostomia e gastrostomia. Um técnico de enfermagem dedicado 24 horas garante acompanhamento contínuo, e a paciente beneficia-se de check-ups médicos regulares, fisioterapia cinco vezes por semana, sessões semanais de fonoaudiologia, consultas mensais com nutricionista e apoio psicológico contínuo aos familiares. Comentários: Esta abordagem multidisciplinar resultou em melhora motora discreta, destacando o impacto positivo do cuidado integral no seu bem-estar geral. A existência de uma rede robusta de apoio às famílias que enfrentam desafios semelhantes é crucial, e um cuidado multidisciplinar pode prevenir eficazmente as complicações associadas a esta impactante síndrome. Objetivo associada care probabilidades devida possivelmente cesariana 3 dias uterino mãe prénatais pré natais saúde nascimento especializado gastrostomia 2 beneficiase beneficia se checkups check ups regulares semana fonoaudiologia familiares Comentários discreta bemestar bem estar geral crucial

ABSTRACT Objective: To recognize and address Patau’s syndrome, despite its rarity and associated low life expectancy, through the presentation of a case study of a 2-year-old patient receiving Home Care services. Case description: We present a female patient who defied the odds with a prolonged survival, possible due to Home Care. She was delivered via cesarean section at 31 weeks + 4 days due to restricted uterine growth. The mother, aged 36, had received proper prenatal care and was in good health. The diagnosis of Patau’s syndrome was confirmed through karyotyping after birth. Despite the severe clinical nature of the case, the patient, now with two years old, receives specialized home-based care, supported by a tracheostomy and gastrostomy. A dedicated 24-hour nursing technician ensures continuous monitoring, and the patient benefits from regular medical check-ups, physiotherapy five times a week, weekly speech therapy sessions, monthly consultations with a nutritionist, and ongoing psychological support for her family members. Comments: This multidisciplinary approach has resulted in a slight motor response, highlighting the positive impact of comprehensive care on her overall well-being. The existence of a robust support network for families facing similar challenges is crucial, and a multidisciplinary care can effectively prevent complications associated with this impactful syndrome. Objective Pataus Patau s expectancy 2yearold yearold 2 year old services description survival 3 growth mother 36 health birth homebased home based gastrostomy 24hour hour 24 monitoring checkups, checkups check ups, ups check-ups week sessions nutritionist members Comments response wellbeing. wellbeing well being. being well-being crucial

This study offers a comprehensive analysis of how governance capacities in developing countries respond to the challenges that COVID-19 posed. We established a theoretical framework to delve into the multifaceted nature of governance capacities, exploring two distinct aspects of governance: the Weberian one, which focuses on material and organizational capacities, and the Tocquevillian one, which focuses on coordination and associational capacities. We examined these four governance dimensions to illustrate how these distinct skills influence the effectiveness of governance. Our analysis quantifies the impact of the COVID-19 pandemic using such metrics as confirmed cases and deaths. We employ standard and dynamic panel data methodologies to mitigate potential omitted variable bias. Our research findings indicate that countries with robust governance capacities, as assessed by the Bertelsmann Stiftung's Transformation Governance Index, are better equipped to respond effectively to pandemic crises. By applying several models and rigorous robustness tests, we demonstrate efficient resource utilization, the ability to guide and prioritize decision-making within the government, and commitment to cooperation and coordination with other nations and international organizations are the primary drivers of improved outcomes. Our findings remain robust even when controlling for relevant variables and employing estimation techniques that account for potential biases arising from unobservable confounding factors. COVID19 COVID 19 COVID-1 posed one deaths bias Stiftungs Stiftung s Index crises tests utilization decisionmaking decision making government outcomes factors COVID1 1 COVID-

ABSTRACT Purpose: This prospective, randomized, unmasked, clinical trial aimed to report the visual outcomes of cataract surgery on both eyes versus cataract surgery on one eye in Brazilian patients. Methods: This study included patients with bilateral cataracts and binocular visual acuity worse than or equal to 0.3 logarithm of the minimum angle of resolution. The patients were randomly assigned to undergo surgery on one (Control Group) or both eyes (one eye at a time; Intervention Group). Postoperatively, self-reported visual function using Catquest-9SF (primary outcome measure), binocular visual acuity, stereopsis, and ocular dominance (secondary outcome measures) were compared. Results: A total of 151 patients (77 and 148 eyes in the Control and Intervention Groups, respectively) completed the follow-up. Patients who underwent surgery on both eyes exhibited significantly better self-reported visual function (p=0.036) and stereopsis (p=0.026) than those who underwent surgery on one eye. Binocular visual acuity and ocular dominance did not affect the group comparisons. Conclusions: Surgery on both eyes resulted in significantly better self-reported visual function and stereopsis than surgery on one eye. Purpose prospective randomized unmasked Methods 03 0 3 0. resolution Group time Group. . Postoperatively selfreported self reported Catquest9SF CatquestSF Catquest 9SF SF primary measure, measure , measure) secondary measures compared Results 15 77 (7 14 Groups respectively followup. followup follow up. up follow-up p=0.036 p0036 p 036 (p=0.036 p=0.026 p0026 026 (p=0.026 comparisons Conclusions 1 7 ( p=0.03 p003 (p=0.03 p=0.02 p002 02 (p=0.02 p=0.0 p00 (p=0.0 p=0. p0 (p=0. p=0 (p=0 p= (p= (p

ABSTRACT: Based on the data of China’s overseas arable land investment in 47 countries along the “Belt and Road”, the Tobit model is used to analyze the effects of cultural distance and friendship cities on the production rates of contracted arable land in China’s overseas arable land investment. This study provided theoretical basis and empirical support for promoting China’s agricultural “going abroad” and improving the production rates of contracted arable land in China’s overseas arable land investment. The results show that differences in cultural distance, power distance and the degree of uncertainty avoidance have significant positive effects on the production rates of contracted arable land in China’s overseas arable land investment, and differences in individualism have a significant negative effect on the production rates. Friendship city has a positive but insignificant effect on the production rates, meanwhile, it also weaken the positive impact of cultural distance on production rates of contracted arable land in China’s overseas arable land investment. The proportion of joint ventures with host country, the economic level and institutional environment of the host country will all have an impact on the production rates. Finally, recommendations are proposed to promote the production rates of contracted arable land, such as focusing on the positive role of cultural distance, establishing friendship cities, and investing host countries with high potential precisely. ABSTRACT Chinas China s 4 Belt Road, Road , Road” going abroad meanwhile Finally precisely

RESUMO: Com base nos dados do investimento da China em terras aráveis no exterior em 47 países ao longo do “Cinturão e Rota”, o modelo Tobit é utilizado para analisar os efeitos da distância cultural e das cidades amigas nas taxas de produção de terras aráveis contratadas no investimento da China em terras aráveis no exterior. Os resultados mostram que as diferenças na distância cultural, na distância de poder e no grau de prevenção de incertezas têm efeitos positivos significativos sobre as taxas de produção de terras aráveis contratadas no investimento em terras aráveis no exterior da China, e as diferenças no individualismo têm um efeito negativo significativo sobre as taxas de produção. As cidades amigas têm um efeito positivo, mas insignificante, sobre as taxas de produção, enquanto estas podem enfraquecer o impacto positivo da distância cultural sobre as taxas de produção de terras aráveis contratadas no investimento em terras aráveis no exterior da China. A proporção de investimento cooperativo entre a China e o país anfitrião, o nível econômico e o ambiente institucional do país anfitrião terão um impacto sobre as taxas de produção. Por fim, são propostas recomendações para promover as taxas de produção das terras aráveis contratadas, tais como a concentração no papel positivo da distância cultural, a criação de cidades da amizade e o investimento em países de acolhimento com elevado potencial. RESUMO 4 Cinturão Rota, Rota , Rota” insignificante fim potencial

RESUMO Objetivo: Verificar a utilização e identificar as vantagens dos métodos moleculares para diagnóstico de infecções congênitas no líquido cefalorraquidiano de neonatos. Fontes de dados: A revisão foi registrada na base PROSPERO (International Prospective Register of Systematic Reviews) sob CRD42021274210. A busca bibliográfica foi realizada nas bases de dados PubMed, Biblioteca Virtual em Saúde/ Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde (BVS/BIREME), Scopus, Web of Science, Excerpta Medica database (EMBASE), Cochrane, ProQuest, e EBSCOhost. A busca foi feita no período de agosto a outubro de 2021 e atualizada em dezembro de 2022, respeitando as orientações do Preferred Reporting Items for Systematic Reviews e Meta-Analyises (PRISMA). A sequência da seleção dos estudos foi: 1) Remoção de duplicatas; 2) Exame de títulos e resumos; 3) Recuperação dos textos completos potencialmente relevantes; e 4) Avaliação do texto completo conforme critérios de elegibilidade por dois autores independentes. O critério de inclusão considerou ensaios clínicos randomizados e não randomizados, estudos longitudinais, transversais, revisados por pares, estudos em humanos, publicados em inglês, espanhol, italiano e português, com recém-nascidos de até 28 dias que sofreram neuroinfecções congênitas pelos agentes toxoplasmose, rubéola, citomegalovírus, herpes simples (TORCH), e outros como Treponema pallidum, Zika, parvovírus B-19, varicela zoster, Epstein-Barr, e SARS-CoV-2, diagnosticadas por reação em cadeia de polimerase (PCR). Dois avaliadores extraíram as seguintes informações: autor, ano de publicação, nacionalidade, sujeitos, tipo de estudo, métodos, resultados e conclusão. Síntese dos dados: O patógeno mais estudado foi Herpes Simples. Muitos artigos relataram somente sintomas iniciais inespecíficos, motivando a coleta de líquido cefalorraquidiano e realização da PCR para investigação etiológica. Conclusões: Os métodos moleculares são eficazes para detectar o genoma do patógeno no líquido cefalorraquidiano, o que pode impactar na evolução clínica e no prognóstico neurológico. Objetivo neonatos International CRD42021274210 CRD PubMed LatinoAmericano Latino Americano BVS/BIREME, BVSBIREME BVS/BIREME , BVS BIREME (BVS/BIREME) Scopus Science EMBASE, EMBASE (EMBASE) Cochrane ProQuest EBSCOhost 202 2022 MetaAnalyises Meta Analyises PRISMA. PRISMA . (PRISMA) 1 duplicatas 2 resumos 3 relevantes 4 independentes longitudinais transversais pares humanos inglês espanhol português recémnascidos recém nascidos toxoplasmose rubéola citomegalovírus TORCH, TORCH (TORCH) pallidum Zika B19, B19 B 19, 19 B-19 zoster EpsteinBarr, EpsteinBarr Epstein Barr, Barr Epstein-Barr SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2, SARS-CoV-2 PCR. (PCR) informações autor publicação nacionalidade sujeitos estudo conclusão Simples inespecíficos etiológica Conclusões neurológico CRD4202127421 (BVS/BIREME (EMBASE 20 (PRISMA (TORCH B1 B-1 SARS-CoV- (PCR CRD420212742 B- SARS-CoV CRD42021274 CRD4202127 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

ABSTRACT Objective: To verify the use and identify advantages of molecular methods for congenital infections diagnosis in cerebrospinal fluid of neonates. Data source: The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), under CRD42021274210. The literature search was performed in databases: PubMed, Virtual Health Library/ Latin American and Caribbean Center on Health Sciences Information (VHL/BIREME), Scopus, Web of Science, Excerpta Medica database (EMBASE), Cochrane, ProQuest, and EBSCOhost. The search was carried out from August to October 2021 and updated in December 2022, respecting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The selection sequence was: 1) Duplicate title removal; 2) Examination of titles and abstracts; 3) Full-text retrieval of potentially relevant reports; and 4) Evaluation of the full text according to eligibility criteria by two independent authors. Inclusion criteria considered randomized and non-randomized control trials, longitudinal, cross-sectional, and peer-reviewed studies in humans, published in English, Spanish, Italian, and Portuguese, with newborns up to 28 days old who had congenital neuroinfections by toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH), and others such as Treponema pallidum, Zika, parvovirus B-19, varicella zoster, Epstein-Barr, and SARS-CoV2, diagnosed by polymerase chain reaction (PCR). Two evaluators extracted the following information: author, year of publication, nationality, subjects, study type, methods, results, and conclusion. Data synthesis: The most studied pathogen was herpes simplex. Several articles reported only nonspecific initial symptoms, motivating the collection of cerebrospinal fluid and performing PCR for etiological investigation. Conclusions: Molecular methods are effective to detect pathogen genomes in cerebrospinal fluid, which can impact clinical evolution and neurological prognosis. Objective neonates source PROSPERO, PROSPERO , (PROSPERO) CRD42021274210 CRD databases PubMed Library VHL/BIREME, VHLBIREME VHL/BIREME VHL BIREME (VHL/BIREME) Scopus Science EMBASE, EMBASE (EMBASE) Cochrane ProQuest EBSCOhost 202 2022 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines 1 removal 2 abstracts 3 Fulltext Full reports 4 authors nonrandomized non trials longitudinal crosssectional, crosssectional cross sectional, sectional cross-sectional peerreviewed peer reviewed humans English Spanish Italian Portuguese toxoplasmosis rubella cytomegalovirus TORCH, TORCH (TORCH) pallidum Zika B19, B19 B 19, 19 B-19 zoster EpsteinBarr, EpsteinBarr Epstein Barr, Barr Epstein-Barr SARSCoV2, SARSCoV2 SARSCoV SARS CoV2, CoV2 CoV SARS-CoV2 PCR. . (PCR) information author publication nationality subjects type results conclusion synthesis symptoms investigation Conclusions prognosis (PROSPERO CRD4202127421 (VHL/BIREME (EMBASE 20 (TORCH B1 B-1 SARS-CoV (PCR CRD420212742 B- CRD42021274 CRD4202127 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

To control vehicle emissions, the new homologation process must be reported according to the California Maximum Incremental Reactivity (MIR) scale’s procedure to calculate the ozone forming potential (OFP) of each new vehicle. This work calculates an MIR scale suitable for the Brazilian reality. Meteorological and hourly pollutant data from the Bangu Automatic Air Quality Station was inventoried and processed from March to September 2020 to adjust OZIPR Lagrangean model and obtain the MIR scale by making small increments in the concentrations of each volatile organic compounds (VOC) and calculate the ozone increase/decrease. It was found that the VOC that had the greatest impact on ozone formation was 1,2,4-trimethylbenzene, with 2.06 ppb O3 ppbC-1 VOC. The OFP was calculated based on the VOC emissions of a vehicle and it was found a value of 9.421 mg O3 km-1, a much lower value when compared using the California MIR scale of 136.608 mg O3 km-1. It is concluded that meteorological conditions and VOC speciation data in the air mixture in the studied region directly affect the photochemical reactions of ozone formation. (MIR scales s (OFP reality 202 (VOC increasedecrease increase decrease increase/decrease 1,2,4trimethylbenzene, 124trimethylbenzene trimethylbenzene 1,2,4 trimethylbenzene, 1 2 4 1,2,4-trimethylbenzene 206 06 2.0 O ppbC1 ppbC ppbC- 9421 9 421 9.42 km1, km1 km 1, km-1 136608 136 608 136.60 km1. 1. 20 4trimethylbenzene 1,2,4trimethylbenzene 124 1,2, 0 2. 942 42 9.4 km- 13660 13 60 136.6 12 1,2 94 9. 1366 6 136.

Selenium-containing compounds exhibit diverse biological activities, such as antioxidative, anti-inflammatory, and cancer preventive effects. Using Caenorhabditis elegans as a model organism, we assessed the toxicity, neuroprotective, antioxidant properties, and impact on longevity of 11 selenoacetylenes. Their toxicity and bioactivities varied based on molecular structure. Selenoacetylenes with butyl substituents were toxic to Galleria mellonella larvae. The presence of but-3-in-2-ol radical increased antiprotozoal activity against Tetrahymena pyriformis. Compared to the positive control (Nimitz® EC), selenoacetylenes were less toxic to nematode worms and eggs. Selenoacetylenes significantly reduced amyloid beta (Aβ) paralysis in C. elegans CL4176 worms, increased longevity by 18 to 22%, along with improving survival after oxidative or thermal stress. Galantamine, showed inferior results. These findings enhance our understanding of selenoacetylenes on neuroprotection, antioxidant activity, and longevity in C. elegans. Future mammalian studies will further elucidate mechanisms and explore the potential therapeutic use of selenoacetylenes in treating Alzheimer’s disease and longevity. Seleniumcontaining Selenium containing activities antioxidative antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory effects organism neuroprotective properties 1 structure larvae but3in2ol butinol but 3 2 ol pyriformis Nimitz® Nimitz (Nimitz EC, EC , EC) eggs Aβ (Aβ C CL CL417 22 22% stress Galantamine results neuroprotection Alzheimers Alzheimer s CL41 CL4

ABSTRACT Purpose: To describe the epidemiological and clinical profile of hospitalized patients with retinoblastoma in Brazil. Methods: Using data from the Hospital Cancer Registry of the Instituto Nacional de Câncer, patients with the morphological codes of retinoblastoma who were diagnosed between 2000 to 2018, aged 0–19 years, and followed up in registered hospitals (analytical cases) were selected. The relative and absolute frequencies of demographic, clinical, diagnostic, therapeutic, and outcome variables were described. Hospital performance indicators were calculated and compared between hospitals qualified and not qualified to treat pediatric oncology cases and between hospitals with different case volumes (<20, 20-75, >75 cases). Results: Of the 2,269 identified analytical cases from 86 institutions, 48% were from the Southeast, 54% were male, and 66% were aged <4 years. The proportion of missing data (NA) was too high for several variables. Approximately 84% of the patients were from the public health system, 40% had a positive family history, and 88% had unilateral involvement. The first treatment included surgery in 58.3% of the patients (NA=2), Approximately 36.6% of these patients achieved complete remission, 10.8% achieved partial remission, and 12.7% died (NA=59%). Hospital performance indicators were within the target in >90% of the patients. The median time between the first appointment and diagnosis (6 days, interquartile range [IQR] 1–14) was significantly lower and the median time to death was longer (343 days, IQR, 212-539) in high-volume hospitals (>75 cases) than in medium- and low-volume hospitals. Conclusions: Despite the high proportion of missing data, we found that the delay in diagnosis is due to prehospital factors. Additionally, there is a need for educational programs for healthcare professionals and families that emphasize early identification and referral to specialized centers. Future studies should focus on the impact of Hospital Cancer Registry data completeness on outcomes, causes of delay in diagnosis, regional inequalities, and barriers to accessing specialized services. Purpose Brazil Methods Câncer 200 2018 019 0 19 0–1 years selected demographic diagnostic therapeutic described <20, 20 (<20 2075, 2075 75, 75 20-75 >7 cases. . Results 2269 2 269 2,26 8 institutions 48 Southeast 54 male 66 4 < NA (NA 84 system 40 history 88 involvement 583 58 3 58.3 NA=2, NA2 NA=2 , (NA=2) 366 36 6 36.6 remission 108 10 10.8 127 12 7 12.7 NA=59%. NA59 NA=59% 59 (NA=59%) 90 >90 ( days IQR [IQR 1–14 114 1 14 343 (34 212539 212 539 212-539 highvolume volume (>7 medium lowvolume low Conclusions factors Additionally centers outcomes inequalities services 201 01 0– <20 (<2 207 20-7 > 226 26 2,2 5 58. NA= (NA=2 36. 10. 12. NA5 NA=59 (NA=59% 9 >9 1–1 11 34 (3 21253 21 53 212-53 (> <2 (< 20- 22 2, (NA= NA=5 (NA=59 1– 2125 212-5 (NA=5 212-

The coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound impact on global health and socio-economic conditions. To date, various vaccines have been administered worldwide in an effort to curb the spread of the virus. Despite vaccination efforts, there have been complications. Existing antiviral drugs have shown limited effectiveness, prompting the use of computational methods to understand the dynamics of the virus and develop suitable treatments. The current study focuses on using biocompatible para-sulfonato-calix[4]arenes to dock against two key proteins of SARS-CoV-2, namely ribonucleic acid (RNA)-dependent RNA polymerase, and helicase. Docking results indicate a strong binding affinity of these compounds to the target proteins, with higher scores compared to commonly used medications. Molecular dynamics (MD) simulation validates the docking results, showing stable protein-ligand complexes over time. The compounds are also screened for absorption, distribution, metabolism, and excretion properties and toxicity, suggesting their potential as lead candidates for inhibiting the virus’s key proteins. However, further in vivo and in vitro studies are recommended to confirm these findings. COVID19 COVID 19 (COVID-19 pandemic SARSCoV2, SARSCoV2 SARSCoV SARS CoV , (SARS-CoV-2) socioeconomic socio economic conditions date efforts complications effectiveness treatments parasulfonatocalix4arenes parasulfonatocalixarenes para sulfonato calix 4 arenes 2, SARS-CoV-2 RNAdependent dependent polymerase helicase medications MD (MD proteinligand protein ligand time absorption distribution metabolism toxicity viruss s However findings COVID1 1 (COVID-1 (SARS-CoV-2 parasulfonatocalix SARS-CoV- (COVID- (SARS-CoV- SARS-CoV (COVID (SARS-CoV